CN112351785A - 利用人脐带组织来源的间充质基质细胞治疗自闭症谱系障碍的方法 - Google Patents

利用人脐带组织来源的间充质基质细胞治疗自闭症谱系障碍的方法 Download PDF

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CN112351785A
CN112351785A CN201980033345.8A CN201980033345A CN112351785A CN 112351785 A CN112351785 A CN 112351785A CN 201980033345 A CN201980033345 A CN 201980033345A CN 112351785 A CN112351785 A CN 112351785A
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msc
cells
patient
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J·库茨贝格
G·道森
J·孙
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Duke University
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Duke University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/16—Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4848—Monitoring or testing the effects of treatment, e.g. of medication
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Hospice & Palliative Care (AREA)
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CN201980033345.8A 2018-04-04 2019-04-04 利用人脐带组织来源的间充质基质细胞治疗自闭症谱系障碍的方法 Pending CN112351785A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862652722P 2018-04-04 2018-04-04
US62/652,722 2018-04-04
PCT/US2019/025716 WO2019195506A1 (en) 2018-04-04 2019-04-04 Methods of treating autism spectrum disorders using human umbilical cord tissue-derived mesenchymal stromal cells

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CN112351785A true CN112351785A (zh) 2021-02-09

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US (1) US12491210B2 (cg-RX-API-DMAC10.html)
EP (1) EP3773486B1 (cg-RX-API-DMAC10.html)
JP (1) JP2021520380A (cg-RX-API-DMAC10.html)
KR (1) KR20210031853A (cg-RX-API-DMAC10.html)
CN (1) CN112351785A (cg-RX-API-DMAC10.html)
AU (1) AU2019247210A1 (cg-RX-API-DMAC10.html)
BR (1) BR112020020295A2 (cg-RX-API-DMAC10.html)
CA (1) CA3096033A1 (cg-RX-API-DMAC10.html)
ES (1) ES2968823T3 (cg-RX-API-DMAC10.html)
IL (1) IL277733B2 (cg-RX-API-DMAC10.html)
SG (1) SG11202009805PA (cg-RX-API-DMAC10.html)
WO (1) WO2019195506A1 (cg-RX-API-DMAC10.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113057969A (zh) * 2021-03-09 2021-07-02 吴志新 一种间充质干细胞对儿童自闭症临床应用实验方法

Families Citing this family (1)

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Publication number Priority date Publication date Assignee Title
WO2025100424A1 (ja) * 2023-11-10 2025-05-15 国立大学法人 東京大学 急性脳症治療剤及び急性脳症の治療方法

Citations (1)

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US20110104100A1 (en) * 2007-10-04 2011-05-05 Medistem Laboratories, Inc. Compositions and methods of stem cell therapy for autism

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ES2580136T3 (es) * 2010-12-16 2016-08-19 Autism Biotech Limited Biomarcador novedoso y usos del mismo en el diagnóstico, tratamiento de autismo
EP3429360A4 (en) * 2016-03-16 2019-08-28 Cell Medicine, Inc. MESENCHYMAL STEM CELLS WITH IMPROVED EFFICACY
US20170296588A1 (en) * 2016-04-19 2017-10-19 AngioStem, Inc. Mesenchymal stem cells derived from placental sources
JP7126703B2 (ja) 2016-05-24 2022-08-29 国立大学法人 東京大学 臍帯由来細胞を含む脳障害の治療剤
US10987381B2 (en) * 2017-01-27 2021-04-27 Neil Riordan Mesenchymal stem cells with enhanced efficacy in treatment of autoimmunity particularly rheumatoid arthritis

Patent Citations (1)

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US20110104100A1 (en) * 2007-10-04 2011-05-05 Medistem Laboratories, Inc. Compositions and methods of stem cell therapy for autism

Non-Patent Citations (9)

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Title
BENJAMIN GESUNDGEIT等: "Therapeutic properties of mesenchymal stem cells for autism spectrum disorders", 《MED HYPOTHESES》 *
DARIO SINISCALCO等: "Autism Spectrum Disorders:Is Mesenchymal Stem Cell Personalized Therapy the Future?", 《J BIOMED BIOTECHNOL》 *
DARIO SINISCALCO等: "Mesenchymal stem cells in treating autism:Novel insights", 《WORLD J STEM CELLS》 *
JESSICA MS等: "Infusion of Human Umbilical Cord Tissue Mesenchymal Stromal Cells in Children With Autism Spectrum Disorder", 《STEM CELLS TRANSL MED》 *
LV YT等: "Transplantation of Human Cord Blood Mononuclear Cells and Umbilical Cord-Derived Mesenchymal Stem Cells in Autism", 《JOURNAL OF TRANSLATIONAL MEDICINE》 *
刘敏等: "干细胞治疗自闭症:安全性和有效性观察", 《中国组织工程研究与临床康复》 *
刘敏等: "脐血单个核细胞和脐带间充质干细胞治疗儿童孤独症的安全性与有效性", 《中国组织工程研究与临床康复》 *
宋秀军等: "干细胞治疗小儿自闭症研究进展(文献综述)", 《放射免疫学杂志》 *
郇英等: "异常行为量表评估干细胞治疗儿童孤独症的临床疗效及效度评价", 《中国医药生物技术》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113057969A (zh) * 2021-03-09 2021-07-02 吴志新 一种间充质干细胞对儿童自闭症临床应用实验方法

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WO2019195506A1 (en) 2019-10-10
JP2021520380A (ja) 2021-08-19
IL277733A (en) 2020-11-30
US20210128631A1 (en) 2021-05-06
EP3773486A4 (en) 2021-12-15
EP3773486C0 (en) 2023-12-06
IL277733B1 (en) 2024-06-01
AU2019247210A1 (en) 2020-11-05
ES2968823T3 (es) 2024-05-14
SG11202009805PA (en) 2020-11-27
IL277733B2 (en) 2024-10-01
KR20210031853A (ko) 2021-03-23
EP3773486B1 (en) 2023-12-06
CA3096033A1 (en) 2019-10-10
BR112020020295A2 (pt) 2021-01-12
EP3773486A1 (en) 2021-02-17
US12491210B2 (en) 2025-12-09

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