CN112315658A - Hydrocolloid dressing and preparation method thereof - Google Patents
Hydrocolloid dressing and preparation method thereof Download PDFInfo
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- CN112315658A CN112315658A CN202011345965.6A CN202011345965A CN112315658A CN 112315658 A CN112315658 A CN 112315658A CN 202011345965 A CN202011345965 A CN 202011345965A CN 112315658 A CN112315658 A CN 112315658A
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- 238000002360 preparation method Methods 0.000 title abstract description 10
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- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 37
- 229920002785 Croscarmellose sodium Polymers 0.000 claims description 36
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- 239000000463 material Substances 0.000 claims description 33
- 239000000919 ceramic Substances 0.000 claims description 27
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- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical group O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 20
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- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
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- BGYHLZZASRKEJE-UHFFFAOYSA-N [3-[3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoyloxy]-2,2-bis[3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoyloxymethyl]propyl] 3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoate Chemical compound CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(CCC(=O)OCC(COC(=O)CCC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)(COC(=O)CCC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)COC(=O)CCC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)=C1 BGYHLZZASRKEJE-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
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- 239000013060 biological fluid Substances 0.000 description 1
- BJQHLKABXJIVAM-UHFFFAOYSA-N bis(2-ethylhexyl) phthalate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 description 1
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- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
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- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- BOXSVZNGTQTENJ-UHFFFAOYSA-L zinc dibutyldithiocarbamate Chemical compound [Zn+2].CCCCN(C([S-])=S)CCCC.CCCCN(C([S-])=S)CCCC BOXSVZNGTQTENJ-UHFFFAOYSA-L 0.000 description 1
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- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01008—Non-adhesive bandages or dressings characterised by the material
- A61F13/01017—Non-adhesive bandages or dressings characterised by the material synthetic, e.g. polymer based
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- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
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- A61F13/00—Bandages or dressings; Absorbent pads
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- A61F13/01021—Non-adhesive bandages or dressings characterised by the structure of the dressing
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- A61F13/0203—Adhesive bandages or dressings with fluid retention members
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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Abstract
The utility model provides a hydrocolloid dressing and preparation method thereof, hydrocolloid dressing includes first hydrocolloid layer, combines in the second hydrocolloid layer of the ascending one side of first hydrocolloid layer orientation and combines in the back sheet of the ascending one side of second hydrocolloid layer orientation, and it prevents backward flow locking mechanism to distribute the seepage liquid in the ascending one side of first hydrocolloid layer orientation, has hydrocolloid laminating reinforcing mechanism in the downward one side of second hydrocolloid layer orientation. The method comprises the following steps: preparing a first hydrocolloid layer; preparing a second hydrocolloid layer, forming hydrocolloid adhesion enhancing mechanisms on the downward side of the second hydrocolloid layer, finally overlapping the downward side of the second hydrocolloid layer to the upward side of the first hydrocolloid layer, combining the seepage backflow prevention water locking mechanisms and the hydrocolloid adhesion enhancing mechanisms with each other, and covering the surface of the upward side of the second hydrocolloid layer with a back lining layer to obtain the hydrocolloid dressing. Seepage backflow is avoided, the frequency of replacing hydrocolloid dressing is reduced, and the wound healing time is shortened; exhibits excellent antibacterial properties.
Description
Technical Field
The invention belongs to the technical field of dressings and preparation thereof, and particularly relates to a hydrocolloid dressing and a preparation method thereof.
Background
As is known in the art, good moisture absorption and retention are generally required for wound care dressings to facilitate the relatively good healing environment of the wound and to help promote wound healing. The hydrocolloid dressing has good capability of absorbing seepage of a wound surface, and after the seepage is absorbed, the hydrophilic particles in the dressing can form gel-like semisolid substances and are attached to the base of the wound, so that a wet environment beneficial to wound healing is provided and maintained.
Since the prior hydrocolloid dressing can not be used for the wound with large seepage liquid, the seepage liquid is easy to overflow to cause damage to the skin around the wound, and the hydrocolloid dressing has no antibacterial property and can cause symptoms such as infection and the like, thereby affecting the healing of the wound. With the development of technology, hydrocolloid dressings with excellent antibacterial effect have been developed to compensate the above disadvantages, and many of such dressings use silver ions, chitosan, quaternary ammonium salts, etc., but since hydrocolloids often require higher temperatures during processing, antibacterial substances contributing to antibacterial properties have a very limited degree of high temperature resistance, and are liable to undergo pyrolysis to reduce or even eliminate the antibacterial active ingredients.
Patents disclosing hydrocolloid dressings and methods for their preparation, typically "hydrocolloid dressings and methods for their preparation" as recommended by CN102488919B, are found in the published chinese patent literature, the hydrocolloid dressings of which comprise: thermoplastic elastomer 5-30% (styrene-isoprene-styrene block copolymer) and tackifier 10-40% (C)5Petroleum resin, terpene resin and rosin resin), water-soluble hydrocolloid 10-50% (sodium carboxymethylcellulose, water-swellable hydrocolloid 10-30%), plasticizer 5-30% (dioctyl phthalate, dioctyl glycol, naphthenic oil) and antioxidant 0-5% (antioxidant 1010 and/or zinc dibutyl dithiocarbamate). The technical effect of the patent is called according to the 0018 paragraph of the specification: has good adhesion to the skin, maintains high integrity after absorbing large amounts of biological fluids, reduces leakage of fluids and leaves no residue on the skin.
The hydrocolloid dressing in the actual finished state is represented by the following form: the hydrocolloid dressing is arranged between a covering layer on the upper part of the hydrocolloid dressing and a release layer on the bottom of the hydrocolloid dressing, the covering layer is usually a polyurethane film, the release layer is usually release paper (also called 'silicone oil paper'), and after the release paper is removed, the hydrocolloid dressing is contacted with a wound, namely the release paper is torn off to apply the hydrocolloid dressing on the wound in use. The strength of the wound exudate absorption capacity is generally regarded as an important index considering the quality of the hydrocolloid dressing, however, the exudate backflow problem after the dressing absorbs the exudate is ignored and at least cannot bring due importance, and in the actual use process, the exudate backflow influences the healing time of the wound, and the frequency of replacing the hydrocolloid application is increased, otherwise, wound infection and damage to the skin around the wound are caused, and the like. In addition, the hydrocolloid dressings of the prior art, including the above-mentioned patent, are more focused on the liquid absorption capability, and have a waste effect on the antibacterial capability, especially the antibacterial component is decomposed due to high temperature during the preparation process, which affects the exertion of the required antibacterial capability.
In view of the above-mentioned prior art, there is a need for reasonable improvement, and the applicant has made various research and trial experiments to develop the technical solution described below.
Disclosure of Invention
The primary task of the present invention is to provide a hydrocolloid dressing that helps to effectively retain wound exudate with good water-holding capacity, to avoid exudate reflux situations, and to reduce dressing changes, to shorten the wound healing time, and to prevent skin effects around the wound.
Another object of the present invention is to provide a method for preparing a hydrocolloid dressing, which can effectively prevent the antibacterial component from being decomposed due to high temperature during the preparation process, so that the prepared hydrocolloid dressing has the required antibacterial effect.
The task of the invention is accomplished by the following steps that the hydrocolloid dressing comprises a first hydrocolloid layer I, a second hydrocolloid layer II combined on one side, facing upwards, of the first hydrocolloid layer I and a backing layer combined on one side, facing upwards, of the second hydrocolloid layer II, liquid seepage backflow prevention and water locking mechanisms are distributed on one side, facing upwards, of the first hydrocolloid layer I at intervals, and a hydrocolloid adhesion enhancing mechanism is formed on one side, facing downwards, of the second hydrocolloid layer II.
In a specific embodiment of the present invention, the liquid-seepage backflow-preventing water-locking mechanism is a water-locking cavity construction tongue formed on the upward-facing side of the first hydrogel layer i in a spaced state, a recessed area formed by the wound liquid seepage of the water-locking cavity construction tongue being turned over relative to the first hydrogel layer i is formed as a water-locking cavity, the depth of the water-locking cavity is equal to the thickness of the water-locking cavity construction tongue, the shape and size of the water-locking cavity are equal to the shape and size of the water-locking cavity construction tongue, and the depth of the water-locking cavity is one third or two fifths of the thickness of the first hydrogel layer i; the hydrocolloid adhesion enhancing mechanism is a groove formed in one downward side of the second hydrocolloid layer II, and the depth of the groove is one third or two fifths of the thickness of the second hydrocolloid layer II.
In another specific embodiment of the present invention, the thickness of the first hydrocolloid layer i is 0.5 to 1.0 mm; the thickness of the second hydrocolloid layer II is 1-5 mm.
In another specific embodiment of the present invention, the first hydrogel layer i comprises the following raw materials by mass: 13-20% of polystyrene-polyisoprene block copolymer, 25-35% of tackifying resin, 13-20% of naphthenic oil, 25-40% of sodium carboxymethyl cellulose, 8-12% of cross-linked sodium carboxymethyl cellulose and 1-2% of antibacterial ceramic powder; the second hydrogel layer II comprises the following raw materials in percentage by mass: 13-20% of polystyrene-polyisoprene block copolymer, 25-35% of tackifying resin, 14-20% of naphthenic oil, 25-40% of sodium carboxymethyl cellulose and 8-12% of cross-linked sodium carboxymethyl cellulose.
In another embodiment of the present invention, the backing layer is a polyurethane film or a silicone film.
In a further specific embodiment of the present invention, the shape of the water-locking cavity is any one or a combination of several of V-shape, prismatic shape, triangular shape, U-shape, n-shape, Jiong-shape and C-shape; the shape of the groove is any one or combination of a plurality of shapes of a # shape, a circular ring shape, a cross criss-cross shape, a plurality of zigzag shapes, a saw tooth shape and a polygon.
In a more specific embodiment of the present invention, the antibacterial ceramic powder is titanium dioxide photocatalytic antibacterial ceramic powder and/or silver-based antibacterial ceramic powder.
Another object of the present invention is to provide a method for preparing a hydrocolloid dressing, comprising the steps of:
A) preparing a first hydrogel layer I, namely preparing the following raw materials in percentage by mass: 13-20% of polystyrene-polyisoprene block copolymer, 25-35% of tackifying resin, 13-20% of naphthenic oil, 25-40% of sodium carboxymethylcellulose, 8-12% of cross-linked sodium carboxymethylcellulose and 1-2% of antibacterial ceramic powder, introducing 13-20% of polystyrene-polyisoprene block copolymer, 25-35% of tackifying resin and 13-20% of naphthenic oil into a vacuum stirrer to mix, controlling the stirring time of the vacuum stirrer and the stirring temperature of the vacuum stirrer to obtain a first mixture, then uniformly mixing 25-40% of sodium carboxymethylcellulose, 8-12% of cross-linked sodium carboxymethylcellulose and 1-2% of antibacterial ceramic powder at normal temperature to obtain a second mixture, then adding the second mixture into the first mixture to continue stirring, controlling the time of continuing stirring and controlling the temperature of continuing stirring, discharging after continuously stirring, coating the material on release paper, cutting the material together with the release paper to obtain a first hydrocolloid layer I, and forming seepage backflow-preventing water locking mechanisms distributed at intervals on one upward side of the first hydrocolloid layer I by using a tool;
B) preparing a second hydrocolloid layer II by preparing the following raw materials in percentage by mass: 13-20% of polystyrene-polyisoprene block copolymer, 25-35% of tackifying resin, 14-20% of naphthenic oil, 25-40% of sodium carboxymethylcellulose and 8-12% of crosslinked sodium carboxymethylcellulose, then 13-20% of polystyrene-polyisoprene block copolymer, 25-35% of tackifying resin and 14-20% of naphthenic oil are put into a vacuum stirrer to be uniformly mixed, the stirring time of the vacuum stirrer and the stirring temperature of the vacuum stirrer are controlled to obtain a first uniform mixture, then 25-40% of sodium carboxymethylcellulose and 8-12% of crosslinked sodium carboxymethylcellulose are uniformly mixed at normal temperature to obtain a second uniform mixture, then the second uniform mixture is added into the first uniform mixture to be stirred, the subsequent stirring time and the subsequent stirring temperature are controlled, and finally, superposing the downward side of the second hydrocolloid layer II on the upward side of the first hydrocolloid layer I to ensure that the seepage backflow prevention water locking mechanism and the hydrocolloid adhesion enhancement mechanism are combined with each other, and covering the upward side surface of the second hydrocolloid layer II with a back lining layer to obtain the hydrocolloid dressing.
In a further specific embodiment of the present invention, the stirring time of the vacuum stirrer in the step a) is controlled to be 55-65min, and the stirring temperature of the vacuum stirrer is controlled to be 175-185 ℃; the time for controlling the continuous stirring is controlled to be 30-40min, and the temperature for controlling the continuous stirring is controlled to be 175-185 ℃.
In still another specific embodiment of the present invention, the stirring time of the vacuum stirrer in the step B) is controlled to be 55-65min, and the stirring temperature of the vacuum stirrer is controlled to be 175-180 ℃; the time for controlling the subsequent stirring is controlled to be 30-40min, and the temperature for controlling the subsequent stirring is controlled to be 175-185 ℃.
The technical scheme provided by the invention has the technical effects that as the surface of the upward side of the first hydrocolloid layer I is provided with the seepage backflow-preventing water locking mechanism, the wound seepage is effectively absorbed and intercepted with good water locking capacity, the seepage backflow is avoided, the frequency of replacing hydrocolloid dressing is reduced, the wound healing time is shortened, and the influence on the intact skin around the wound is avoided; the first hydrocolloid layer I and the second hydrocolloid layer II can be reliably combined with each other through the liquid seepage anti-backflow water locking mechanism formed on the upward side of the first hydrocolloid layer I and the hydrocolloid adhesion enhancing mechanism formed on the downward side of the second hydrocolloid layer II; the hydrocolloid dressing prepared by the preparation method contains reasonable amount of antibacterial ceramic powder, so that excellent antibacterial property can be embodied, and the technical effect of the hydrocolloid dressing can be comprehensively embodied.
Drawings
Fig. 1 is a schematic cross-sectional view of a hydrocolloid dressing of the invention.
Fig. 2 is an enlarged structural view of the first hydrogel layer i shown in fig. 1.
Fig. 3 is an enlarged structural view of the second hydrocolloid layer ii shown in fig. 1 after being turned 180 °.
Fig. 4 is an enlarged view of a portion a of fig. 2.
Detailed Description
In order to clearly understand the technical spirit and the advantages of the present invention, the applicant below describes in detail by way of example, but the description of the example is not intended to limit the technical scope of the present invention, and any equivalent changes made according to the present inventive concept, which are merely in form and not in material, should be considered as the technical scope of the present invention.
In the following description, all the concepts related to the upper and lower directions or orientations are exemplified by the position state of fig. 1, and thus, it should not be understood as a specific limitation to the technical solution provided by the present invention.
Example 1:
referring to fig. 1 to 4, the method for preparing the hydrocolloid dressing with the structure shown in fig. 1 to 4 comprises the following steps:
A) preparing a first hydrogel layer I1, namely preparing the following raw materials in percentage by mass: 20% of polystyrene-polyisoprene block copolymer, 25% of tackifying resin, 16% of naphthenic oil, 30% of sodium carboxymethyl cellulose, 8% of cross-linked sodium carboxymethyl cellulose and 1% of titanium dioxide photocatalytic antibacterial ceramic powder, introducing the 20% of polystyrene-polyisoprene block copolymer, 25% of tackifying resin and 16% of naphthenic oil into a vacuum stirrer for mixing, controlling the stirring time of the vacuum stirrer to be 60min and the stirring temperature of the vacuum stirrer to be 180 ℃ to obtain a first mixture, then uniformly mixing the 30% of sodium carboxymethyl cellulose, 8% of cross-linked sodium carboxymethyl cellulose and 1% of titanium dioxide photocatalytic antibacterial ceramic powder at normal temperature to obtain a second mixture, then adding the second mixture into the first mixture for continuously stirring, controlling the time for continuously stirring to be 30min and controlling the temperature for continuously stirring to be 185 ℃, after the stirring is continued, the mixture is discharged and coated on release paper serving as release paper 4, and then the mixture is cut together with the release paper 4 to obtain a first hydrocolloid layer i 1, the thickness of the mixture coated on the release paper 4 is controlled to be 0.5mm, then a tool such as a mold or a cutter or other equivalent tools forms, for example, cuts out seepage backflow-preventing water-locking mechanisms 11 distributed in a spaced state on one side of the first hydrocolloid layer i 1 facing upwards, the seepage backflow-preventing water-locking mechanisms 11 are water-locking cavity construction tongues 111 formed in a spaced state on one side of the first hydrocolloid layer i 1 facing upwards, a water-locking cavity 112 is formed by wound seepage to turn over (also can be called as "warping up" or "displacement") the water-locking cavity construction tongues 111 in a direction away from the first hydrocolloid layer i 1, the depth of the water-locking cavity 112 is equal to the thickness of the water-locking cavity construction tongues 111, and the shape and size of the water-locking cavity 112 are equal to the water-locking cavity construction tongues 111, according to the general knowledge, at least one edge of the water-locking cavity construction tongue 111 is kept in a connection state with the first hydrogel layer i 1, so that the water-locking cavity construction tongue 111 has a door-leaf opening and closing effect relative to the water-locking cavity 112, i.e. relative to the first hydrogel layer i 1, the water-locking cavity 112 is formed when the water-locking cavity construction tongue 111 is opened, and the water-locking cavity 112 is compensated by the water-locking cavity 112 when the water-locking cavity construction tongue is closed, in the embodiment, the water-locking cavity 112 is in a V shape (also called as a triangle), and the depth of the water-locking cavity 112 is one third of the thickness of the first hydrogel layer i 1;
B) preparing a second hydrocolloid layer II 2 by preparing the following raw materials in percentage by mass: 20% of polystyrene-polyisoprene block copolymer, 25% of tackifying resin, 17% of naphthenic oil, 30% of sodium carboxymethylcellulose and 8% of crosslinked sodium carboxymethylcellulose, then putting 20% of polystyrene-polyisoprene block copolymer, 25% of tackifying resin and 17% of naphthenic oil into a vacuum stirrer to be uniformly mixed, controlling the stirring time of the vacuum stirrer to be 60min and the stirring temperature of the vacuum stirrer to be 180 ℃ to obtain a first uniform mixture, then uniformly mixing 30% of sodium carboxymethylcellulose and 8% of crosslinked sodium carboxymethylcellulose at normal temperature to obtain a second uniform mixture, then adding the second uniform mixture into the first uniform mixture to be stirred, controlling the stirring time to be 30min and the stirring temperature to be 185 ℃, obtaining a material to be pressed, pressing the material to be pressed into a block by adopting a pressing tool such as a mould at 100 ℃, the surface area of the block body facing the first hydrocolloid layer I1 obtained in the step A) is the same as the surface area of the first hydrocolloid layer I1 facing upward to obtain a second hydrocolloid layer II 2, and a hydrocolloid adhesion enhancing means 21 is formed on the side of the second hydrocolloid layer II 2 facing downward, the hydrocolloid adhesion enhancing means 21 is formed by the mold when pressing the material to be pressed into the block body, the thickness of the second hydrocolloid layer II 2 is 5mm, the hydrocolloid adhesion enhancing means 21 is substantially a groove 211 formed on the side of the second hydrocolloid layer II 2 facing downward, the groove 211 is formed by a convex strip formed on the mold, the depth of the groove 211 is one third of the thickness of the second hydrocolloid layer II 2, the shape of the groove 211 is in a # shape, and finally the side of the second hydrocolloid layer II 2 facing downward is superposed on the side of the first hydrocolloid layer I1 facing upward, the seepage liquid anti-backflow water locking mechanism 11 and the hydrocolloid bonding and enhancing mechanism 21 are combined with each other, and the surface of one upward side of the second hydrocolloid layer II 2 is covered with a back lining layer 3 made of a polyurethane film, so that the hydrocolloid dressing is obtained.
Example 2:
referring to fig. 1 to 4, the method for preparing the hydrocolloid dressing with the structure shown in fig. 1 to 4 comprises the following steps:
A) preparing a first hydrogel layer I1, namely preparing the following raw materials in percentage by mass: 13 percent of polystyrene-polyisoprene block copolymer, 30 percent of tackifying resin, 18 percent of naphthenic oil, 25 percent of sodium carboxymethyl cellulose, 12 percent of cross-linked sodium carboxymethyl cellulose and 2 percent of silver-based antibacterial ceramic powder, then 13 percent of polystyrene-polyisoprene block copolymer, 30 percent of tackifying resin and 18 percent of naphthenic oil are introduced into a vacuum mixer to be mixed, the stirring time of the vacuum mixer is controlled to be 55min, the stirring temperature of the vacuum mixer is controlled to be 185 ℃, a first mixture is obtained, then 25 percent of sodium carboxymethyl cellulose, 12 percent of cross-linked sodium carboxymethyl cellulose and 2 percent of silver-based antibacterial ceramic powder are uniformly mixed at normal temperature, a second mixture is obtained, then the second mixture is added into the first mixture to be continuously stirred, the continuous stirring time is controlled to be 35min, the continuous stirring temperature is controlled to be 180 ℃, discharging is carried out after the continuous stirring is finished, and the mixture is coated on release paper serving as release paper 4, then, the material is cut together with the release paper 4 to obtain a first hydrogel layer i 1, the thickness of the material coated on the release paper 4 is controlled to be 1mm, then, a tool such as a mold or a knife or other equivalent tools is used to form, for example, a seepage backflow-preventing water-locking mechanism 11 distributed at intervals on the upward side of the first hydrogel layer i 1, the seepage backflow-preventing water-locking mechanism 11 is a water-locking cavity construction tongue 111 formed at intervals on the upward side of the first hydrogel layer i 1, a recessed area formed by turning (also called "tilting" or "displacement") the water-locking cavity construction tongue 111 in the direction away from the first hydrogel layer i 1 by wound seepage is formed as a water-locking cavity 112, the depth of the water-locking cavity 112 is equal to the thickness of the water-locking cavity construction tongue 111, and the shape and size of the water-locking cavity 112 are the same as the water-locking cavity construction tongue 111, according to the professional knowledge, at least one edge part of the water locking cavity construction tongue 111 is kept in a connection state with the first hydrocolloid layer I1, so that the water locking cavity construction tongue 111 has a door leaf opening and closing effect relative to the water locking cavity 112, namely relative to the first hydrocolloid layer I1, the water locking cavity 112 is formed when the water locking cavity construction tongue is opened, and the water locking cavity 112 is compensated by the water locking cavity 112 when the water locking cavity construction tongue is closed, in the embodiment, the shape of the water locking cavity 112 is in a U shape different from the shape shown in figures 2 and 4, and the depth of the water locking cavity 112 is one third of the thickness of the first hydrocolloid layer I1;
B) preparing a second hydrocolloid layer II 2 by preparing the following raw materials in percentage by mass: 16% of polystyrene-polyisoprene block copolymer, 35% of tackifying resin, 14% of naphthenic oil, 25% of sodium carboxymethylcellulose and 10% of crosslinked sodium carboxymethylcellulose, then putting 16% of polystyrene-polyisoprene block copolymer, 35% of tackifying resin and 14% of naphthenic oil into a vacuum stirrer to be uniformly mixed, controlling the stirring time of the vacuum stirrer to be 55min and the stirring temperature of the vacuum stirrer to be 185 ℃ to obtain a first uniform mixture, then uniformly mixing 25% of sodium carboxymethylcellulose and 10% of crosslinked sodium carboxymethylcellulose at normal temperature to obtain a second uniform mixture, then adding the second uniform mixture into the first uniform mixture to be stirred, controlling the stirring time to be 35min and the stirring temperature to be 180 ℃ to obtain a material to be pressed, pressing the material to be pressed into a block by adopting a pressing tool such as a mould at 100 ℃, the surface area of the block body facing the first hydrocolloid layer I1 obtained in the step A) is the same as the surface area of the first hydrocolloid layer I1 facing upward to obtain a second hydrocolloid layer II 2, and a hydrocolloid adhesion enhancing means 21 is formed on the side of the second hydrocolloid layer II 2 facing downward, the hydrocolloid adhesion enhancing means 21 is formed by the mold when pressing the material to be pressed into a block body, the thickness of the second hydrocolloid layer II 2 is 1mm, the hydrocolloid adhesion enhancing means 21 is substantially a groove 211 formed on the side of the second hydrocolloid layer II 2 facing downward, the groove 211 is formed by a convex strip formed on the mold, the depth of the groove 211 is two-fifths of the thickness of the second hydrocolloid layer II 2, the shape of the groove 211 is a circular ring, and finally the side of the second hydrocolloid layer II 2 facing downward is superposed on the side of the first hydrocolloid layer I1 facing upward, the seepage liquid anti-backflow water locking mechanism 11 and the hydrocolloid bonding and enhancing mechanism 21 are combined with each other, and the surface of one upward side of the second hydrocolloid layer II 2 is covered with the back lining layer 3 made of a silica gel film, so that the hydrocolloid dressing is obtained.
Example 3:
referring to fig. 1 to 4, the method for preparing the hydrocolloid dressing with the structure shown in fig. 1 to 4 comprises the following steps:
A) preparing a first hydrogel layer I1, namely preparing the following raw materials in percentage by mass: 13 percent of polystyrene-polyisoprene block copolymer, 25 percent of tackifying resin, 13 percent of naphthenic oil, 40 percent of sodium carboxymethyl cellulose, 8 percent of cross-linked sodium carboxymethyl cellulose and 1 percent of titanium dioxide photocatalytic antibacterial ceramic powder, then introducing the 13 percent of polystyrene-polyisoprene block copolymer, 25 percent of tackifying resin and 13 percent of naphthenic oil into a vacuum stirrer for mixing, controlling the stirring time of the vacuum stirrer to be 65min and the stirring temperature of the vacuum stirrer to be 175 ℃ to obtain a first mixture, then uniformly mixing 40 percent of sodium carboxymethyl cellulose, 8 percent of cross-linked sodium carboxymethyl cellulose and 1 percent of titanium dioxide photocatalytic antibacterial ceramic powder at normal temperature to obtain a second mixture, then adding the second mixture into the first mixture for continuously stirring, controlling the time for continuously stirring to be 40min and controlling the temperature for continuously stirring to be 175 ℃, after the stirring is continued, the mixture is discharged and coated on release paper serving as release paper 4, and then the mixture is cut together with the release paper 4 to obtain a first hydrocolloid layer i 1, the thickness of the mixture coated on the release paper 4 is controlled to be 0.8mm, then a tool such as a mold or a cutter or other equivalent tools forms, for example, cuts out seepage backflow-preventing water-locking mechanisms 11 distributed in a spaced state on one side of the first hydrocolloid layer i 1 facing upwards, the seepage backflow-preventing water-locking mechanisms 11 are water-locking cavity construction tongues 111 formed in a spaced state on one side of the first hydrocolloid layer i 1 facing upwards, a water-locking cavity 112 is formed by wound seepage to turn over (also can be called as "warping up" or "displacement") the water-locking cavity construction tongues 111 in a direction away from the first hydrocolloid layer i 1, the depth of the water-locking cavity 112 is equal to the thickness of the water-locking cavity construction tongues 111, and the shape and size of the water-locking cavity 112 are equal to the water-locking cavity construction tongues 111, according to the conventional knowledge, at least one edge of the water-locking cavity construction tongue 111 is kept connected with the first hydrogel layer i 1, so that the water-locking cavity construction tongue 111 has a door-like opening and closing effect relative to the water-locking cavity 112, i.e. relative to the first hydrogel layer i 1, the water-locking cavity 112 is formed when the water-locking cavity construction tongue is opened, and the water-locking cavity 112 is compensated by the water-locking cavity 112 when the water-locking cavity construction tongue is closed, in the embodiment, the shape of the water-locking cavity 112 is Jiong different from the shape shown in fig. 2 and 4, and the depth of the water-locking cavity 112 is one third of the thickness of the first hydrogel layer i 1;
B) preparing a second hydrocolloid layer II 2 by preparing the following raw materials in percentage by mass: 13 percent of polystyrene-polyisoprene block copolymer, 25 percent of tackifying resin, 15 percent of naphthenic oil, 35 percent of sodium carboxymethylcellulose and 12 percent of crosslinked sodium carboxymethylcellulose, then putting the 13 percent of polystyrene-polyisoprene block copolymer, 25 percent of tackifying resin and 15 percent of naphthenic oil into a vacuum stirrer to be uniformly mixed, controlling the stirring time of the vacuum stirrer to be 65min and the stirring temperature of the vacuum stirrer to be 180 ℃ to obtain a first uniform mixture, then uniformly mixing 35 percent of sodium carboxymethylcellulose and 12 percent of crosslinked sodium carboxymethylcellulose at normal temperature to obtain a second uniform mixture, then adding the second uniform mixture into the first uniform mixture to be stirred, controlling the stirring time to be 40min and the stirring temperature to be 175 ℃ to obtain a material to be pressed, pressing the material to be pressed into a block by adopting a pressing tool such as a mould at 100 ℃, the surface area of the block body facing the first hydrocolloid layer I1 obtained in the step A) is the same as the surface area of the first hydrocolloid layer I1 facing upward to obtain a second hydrocolloid layer II 2, a hydrocolloid adhesion enhancing means 21 is formed on the side of the second hydrocolloid layer II 2 facing downward, the hydrocolloid adhesion enhancing means 21 is formed by the mold when pressing the material to be pressed into the block body, the thickness of the second hydrocolloid layer II 2 is 4mm, the hydrocolloid adhesion enhancing means 21 is substantially a groove 211 formed on the side of the second hydrocolloid layer II 2 facing downward, the groove 211 is formed by a convex strip formed on the mold, the depth of the groove 211 is one third of the thickness of the second hydrocolloid layer II 2, the shape of the groove 211 is a crisscross shape, and finally the side of the second hydrocolloid layer II 2 facing downward is superposed on the side of the first hydrocolloid layer I1 facing upward, the seepage liquid anti-backflow water locking mechanism 11 and the hydrocolloid bonding and enhancing mechanism 21 are combined with each other, and the surface of one upward side of the second hydrocolloid layer II 2 is covered with a back lining layer 3 made of a polyurethane film, so that the hydrocolloid dressing is obtained.
Example 4:
referring to fig. 1 to 4, the method for preparing the hydrocolloid dressing with the structure shown in fig. 1 to 4 comprises the following steps:
A) preparing a first hydrogel layer I1, namely preparing the following raw materials in percentage by mass: 20 percent of polystyrene-polyisoprene block copolymer, 30 percent of tackifying resin, 15 percent of naphthenic oil, 25 percent of sodium carboxymethyl cellulose, 8.5 percent of cross-linked sodium carboxymethyl cellulose and 1.5 percent of titanium dioxide photocatalytic antibacterial ceramic powder, then introducing 20 percent of polystyrene-polyisoprene block copolymer, 30 percent of tackifying resin and 15 percent of naphthenic oil into a vacuum stirrer for mixing, controlling the stirring time of the vacuum stirrer to be 60min and the stirring temperature of the vacuum stirrer to be 180 ℃ to obtain a first mixture, then uniformly mixing 25 percent of sodium carboxymethyl cellulose, 8.5 percent of cross-linked sodium carboxymethyl cellulose and 1.5 percent of titanium dioxide photocatalytic antibacterial ceramic powder at normal temperature to obtain a second mixture, then adding the second mixture into the first mixture for continuously stirring, controlling the time for continuously stirring to be 30min and controlling the temperature for continuously stirring to be 185 ℃, after the stirring is continued, the mixture is discharged and coated on release paper serving as release paper 4, and then the mixture is cut together with the release paper 4 to obtain a first hydrocolloid layer i 1, the thickness of the mixture coated on the release paper 4 is controlled to be 0.7mm, then a tool such as a mold or a cutter or other equivalent tools forms, for example, cuts out seepage backflow-preventing water-locking mechanisms 11 distributed in a spaced state on one side of the first hydrocolloid layer i 1 facing upwards, the seepage backflow-preventing water-locking mechanisms 11 are water-locking cavity construction tongues 111 formed in a spaced state on one side of the first hydrocolloid layer i 1 facing upwards, a water-locking cavity 112 is formed by wound seepage to turn over (also can be called as "warping up" or "displacement") the water-locking cavity construction tongues 111 in a direction away from the first hydrocolloid layer i 1, the depth of the water-locking cavity 112 is equal to the thickness of the water-locking cavity construction tongues 111, and the shape and size of the water-locking cavity 112 are equal to the water-locking cavity construction tongues 111, according to the common knowledge, at least one edge of the water-locking cavity construction tongue 111 is kept in a connection state with the first hydrogel layer i 1, so that the water-locking cavity construction tongue 111 has a door-like opening and closing effect relative to the water-locking cavity 112, namely relative to the first hydrogel layer i 1, the water-locking cavity 112 is formed when the water-locking cavity construction tongue is opened, and the water-locking cavity 112 is compensated by the water-locking cavity 112 when the water-locking cavity construction tongue is closed, in the embodiment, the shape of the water-locking cavity 112 is prismatic and is different from the shapes shown in fig. 2 and 4, and the depth of the water-locking cavity 112 is two fifths of the thickness of the first hydrogel layer i 1;
B) preparing a second hydrocolloid layer II 2 by preparing the following raw materials in percentage by mass: 15% of polystyrene-polyisoprene block copolymer, 30% of tackifying resin, 19% of naphthenic oil, 28% of sodium carboxymethylcellulose and 8% of crosslinked sodium carboxymethylcellulose, then putting 15% of polystyrene-polyisoprene block copolymer, 30% of tackifying resin and 19% of naphthenic oil into a vacuum stirrer to be uniformly mixed, controlling the stirring time of the vacuum stirrer to be 60min and the stirring temperature of the vacuum stirrer to be 180 ℃ to obtain a first uniform mixture, then uniformly mixing 28% of sodium carboxymethylcellulose and 8% of crosslinked sodium carboxymethylcellulose at normal temperature to obtain a second uniform mixture, then adding the second uniform mixture into the first uniform mixture to be stirred, controlling the stirring time to be 30min and the stirring temperature to be 185 ℃, obtaining a material to be pressed, pressing the material to be pressed into a block by adopting a pressing tool such as a mould at 100 ℃, the surface area of the block body facing the first hydrocolloid layer I1 obtained in the step A) is the same as the surface area of the first hydrocolloid layer I1 facing upward to obtain a second hydrocolloid layer II 2, and a hydrocolloid adhesion enhancing means 21 is formed on the side of the second hydrocolloid layer II 2 facing downward, the hydrocolloid adhesion enhancing means 21 is formed by the mold when pressing the material to be pressed into the block body, the thickness of the second hydrocolloid layer II 2 is 3mm, the hydrocolloid adhesion enhancing means 21 is substantially a groove 211 formed on the side of the second hydrocolloid layer II 2 facing downward, the groove 211 is formed by a convex strip formed on the mold, the depth of the groove 211 is one third of the thickness of the second hydrocolloid layer II 2, the shape of the groove 211 is zigzag, and finally the side of the second hydrocolloid layer II 2 facing downward is overlapped to the side of the first hydrocolloid layer I1 facing upward, the seepage liquid anti-backflow water locking mechanism 11 and the hydrocolloid bonding and enhancing mechanism 21 are combined with each other, and the surface of one upward side of the second hydrocolloid layer II 2 is covered with a back lining layer 3 made of a polyurethane film, so that the hydrocolloid dressing is obtained.
Example 5:
referring to fig. 1 to 4, the method for preparing the hydrocolloid dressing with the structure shown in fig. 1 to 4 comprises the following steps:
A) preparing a first hydrogel layer I1, namely preparing the following raw materials in percentage by mass: 14% of polystyrene-polyisoprene block copolymer, 35% of tackifying resin, 15% of naphthenic oil, 25% of sodium carboxymethylcellulose, 10% of cross-linked sodium carboxymethylcellulose and 1% of silver-based antibacterial ceramic powder, introducing the 14% of polystyrene-polyisoprene block copolymer, 35% of tackifying resin and 15% of naphthenic oil into a vacuum stirrer for mixing, controlling the stirring time of the vacuum stirrer to be 58min and the stirring temperature of the vacuum stirrer to be 182 ℃ to obtain a first mixture, then uniformly mixing the 25% of sodium carboxymethylcellulose, 10% of cross-linked sodium carboxymethylcellulose and 1% of silver-based antibacterial ceramic powder at normal temperature to obtain a second mixture, then adding the second mixture into the first mixture for continuously stirring, controlling the time for continuously stirring to be 35min and the temperature for continuously stirring to be 180 ℃, discharging after the continuous stirring is finished, and coating the mixture on release paper serving as release paper 4, cutting the material together with the release paper 4 to obtain a first hydrogel layer I1, wherein the thickness of the material coated on the release paper 4 is controlled to be 0.6mm, forming, for example, cutting a water-locking cavity construction tongue 111 formed at a spacing state on the upward side of the first hydrogel layer I1 by a tool, such as a die or a cutter or other equivalent tools, forming a water-locking cavity construction tongue 112 by turning (also referred to as "tilting" or "displacement") the water-locking cavity construction tongue 111 in a direction away from the first hydrogel layer I1 by wound exudate, wherein the water-locking cavity 112 is formed as a water-locking cavity 112, the depth of the water-locking cavity 112 is equal to the thickness of the water-locking cavity construction tongue 111, and the shape and size of the water-locking cavity 112 are equal to the water-locking cavity construction tongue 111, and according to the common knowledge, at least one edge part of the water-locking cavity construction tongue 111 is kept in a connected state with the first hydrogel layer I1, so that the water-locking cavity constructing tongue 111 has a door-leaf opening and closing effect relative to the water-locking cavity 112, i.e. relative to the first hydrocolloid layer i 1, the water-locking cavity 112 is formed when the water-locking cavity is opened, and the water-locking cavity 112 is compensated by the water-locking cavity when the water-locking cavity is closed, in the embodiment, the shape of the water-locking cavity 112 is a combination of a C shape and a V shape which are different from the shapes shown in fig. 2 and 4, and the depth of the water-locking cavity 112 is two fifths of the thickness of the first hydrocolloid layer i 1;
B) preparing a second hydrocolloid layer II 2 by preparing the following raw materials in percentage by mass: 13 percent of polystyrene-polyisoprene block copolymer, 25 percent of tackifying resin, 14 percent of naphthenic oil, 40 percent of sodium carboxymethyl cellulose and 8 percent of crosslinked sodium carboxymethyl cellulose, then putting the 13 percent of polystyrene-polyisoprene block copolymer, 25 percent of tackifying resin and 14 percent of naphthenic oil into a vacuum mixer to be mixed uniformly, controlling the mixing time of the vacuum mixer to be 58min and the mixing temperature of the vacuum mixer to be 182 ℃ to obtain a first mixed material, then uniformly mixing 40 percent of sodium carboxymethyl cellulose and 8 percent of crosslinked sodium carboxymethyl cellulose at normal temperature to obtain a second mixed material, then adding the second mixed material into the first mixed material to be stirred, then controlling the stirring time to be 35min and the stirring temperature to be 182 ℃ to obtain a material to be pressed, pressing the material to be pressed into a block body by adopting a pressing tool such as a mould at 100 ℃, the surface area of the block-shaped body facing the first hydrogel layer I1 obtained in step A) is the same as the surface area of the first hydrogel layer I1 facing upward to obtain a second hydrogel layer II 2, and a hydrocolloid adhesion enhancing means 21 is formed on the side of the second hydrogel layer II 2 facing downward, the hydrocolloid adhesion enhancing means 21 is formed by the mold when the material to be pressed is pressed into the block-shaped body, the thickness of the second hydrogel layer II 2 is 2mm, the hydrocolloid adhesion enhancing means 21 is substantially a groove 211 formed on the side of the second hydrogel layer II 2 facing downward, the groove 211 is formed by a convex strip formed on the mold, the depth of the groove 211 is two fifths of the thickness of the second hydrogel layer II 2, the shape of the groove 211 is a polygon such as a hexagon, and finally the side of the second hydrogel layer II 2 facing downward is superposed on the side of the first hydrogel layer I1 facing upward, the seepage liquid anti-backflow water locking mechanism 11 and the hydrocolloid bonding and enhancing mechanism 21 are combined with each other, and the surface of one upward side of the second hydrocolloid layer II 2 is covered with a back lining layer 3 made of a polyurethane film, so that the hydrocolloid dressing is obtained.
Example 6:
referring to fig. 1 to 4, the method for preparing the hydrocolloid dressing with the structure shown in fig. 1 to 4 comprises the following steps:
A) preparing a first hydrogel layer I1, namely preparing the following raw materials in percentage by mass: 16% of polystyrene-polyisoprene block copolymer, 25% of tackifying resin, 20% of naphthenic oil, 26% of sodium carboxymethylcellulose, 11% of cross-linked sodium carboxymethylcellulose, 1% of titanium dioxide photocatalytic antibacterial ceramic powder and 1% of silver-based antibacterial ceramic powder, introducing the 16% of polystyrene-polyisoprene block copolymer, 25% of tackifying resin and 20% of naphthenic oil into a vacuum stirrer for mixing, controlling the stirring time of the vacuum stirrer to be 62min and the stirring temperature of the vacuum stirrer to be 178 ℃ to obtain a first mixture, then uniformly mixing the 26% of sodium carboxymethylcellulose, 11% of cross-linked sodium carboxymethylcellulose, 1% of titanium dioxide photocatalytic antibacterial ceramic powder and 1% of silver-based antibacterial ceramic powder at normal temperature to obtain a second mixture, then adding the second mixture into the first mixture for continuous stirring, controlling the continuous stirring time to be 40min and controlling the continuous stirring temperature to be 175 DEG C After the stirring is continued, the mixture is discharged and coated on release paper serving as release paper 4, and then the mixture is cut together with the release paper 4 to obtain a first hydrocolloid layer i 1, the thickness of the mixture coated on the release paper 4 is controlled to be 0.9mm, a water-locking cavity construction tongue 111 formed at the upward side of the first hydrocolloid layer i 1 in a spaced state is formed on the upward side of the first hydrocolloid layer i 1 by a tool such as a mold or a cutter or other equivalent tools, a recessed area formed by turning (also referred to as "lifting up" or "displacement") the water-locking cavity construction tongue 111 in a direction away from the first hydrocolloid layer i 1 by wound exudate is formed as a water-locking cavity 112, the depth of the water-locking cavity 112 is equal to the thickness of the water-locking cavity construction tongue 111, and the shape and size of the water-locking cavity 112 are the same as the water-locking cavity construction tongue 111, according to the general knowledge, at least one edge part of the water locking cavity construction tongue 111 is kept in a connection state with the first hydrocolloid layer I1, so that the water locking cavity construction tongue 111 has a door leaf opening and closing effect relative to the water locking cavity 112, namely relative to the first hydrocolloid layer I1, the water locking cavity 112 is formed when the water locking cavity construction tongue is opened, and the water locking cavity 112 is compensated by the water locking cavity 112 when the water locking cavity construction tongue is closed, in the embodiment, the shape of the water locking cavity 112 is formed by combining an Jiong shape and a U shape which are different from the shapes shown in figures 2 and 4, and the depth of the water locking cavity 112 is two fifths of the thickness of the first hydrocolloid layer I1;
B) preparing a second hydrocolloid layer II 2 by preparing the following raw materials in percentage by mass: 14% of polystyrene-polyisoprene block copolymer, 35% of tackifying resin, 16% of naphthenic oil, 26% of sodium carboxymethylcellulose and 9% of crosslinked sodium carboxymethylcellulose, then putting 14% of polystyrene-polyisoprene block copolymer, 35% of tackifying resin and 16% of naphthenic oil into a vacuum stirrer to be uniformly mixed, controlling the stirring time of the vacuum stirrer to be 60min and the stirring temperature of the vacuum stirrer to be 178 ℃ to obtain a first uniform mixture, then uniformly mixing 26% of sodium carboxymethylcellulose and 9% of crosslinked sodium carboxymethylcellulose at normal temperature to obtain a second uniform mixture, then adding the second uniform mixture into the first uniform mixture to be stirred, controlling the stirring time to be 40min and the stirring temperature to be 175 ℃, obtaining a material to be pressed, pressing the material to be pressed into a block by adopting a pressing tool such as a mould at 100 ℃, the surface area of the block body facing the first hydrocolloid layer I1 obtained in the step A) is the same as the surface area of the first hydrocolloid layer I1 facing upward to obtain a second hydrocolloid layer II 2, a hydrocolloid adhesion enhancing means 21 is formed on the side of the second hydrocolloid layer II 2 facing downward, the hydrocolloid adhesion enhancing means 21 is formed by the mold when pressing the material to be pressed into the block body, the thickness of the second hydrocolloid layer II 2 is 4.5mm, the hydrocolloid adhesion enhancing means 21 is substantially a groove 211 formed on the side of the second hydrocolloid layer II 2 facing downward, the groove 211 is formed by a convex strip formed on the mold, the depth of the groove 211 is two-fifths of the thickness of the second hydrocolloid layer II 2, the shape of the groove 211 is a combination of a plurality of zigzag shapes and a plurality of circular shapes, and finally the side of the second hydrocolloid layer II 2 facing downward is superposed on the side of the first hydrocolloid layer I1 facing upward And combining the seepage liquid anti-backflow water locking mechanism 11 and the hydrocolloid adhesion enhancing mechanism 21, and covering the back lining layer 3 made of a polyurethane film on the surface of the upward side of the second hydrocolloid layer II 2 to obtain the hydrocolloid dressing.
When the hydrocolloid dressings obtained in examples 1 to 6 were used, the release paper 4 described above was removed and the first hydrocolloid layer i 1 was applied to the wound.
The following are the antibacterial tests and the liquid absorption performance tests of the hydrocolloid dressing obtained in example 1 by the applicant, the results of the antibacterial tests are shown in table 1, and the results of the liquid absorption performance tests are shown in table 2. Since the hydrocolloid dressings obtained in examples 2 to 6 also have excellent antibacterial and liquid-absorbing properties comparable to those of the hydrocolloid dressing obtained in example 1, they are not tabulated.
Weighing 0.75g of the hydrocolloid dressing obtained in example 1, adding the hydrocolloid dressing into 100ml of physiological saline, adding the hydrocolloid dressing into a bacterial suspension with a proper concentration after high-temperature sterilization, wherein the bacterial suspension can be one of escherichia coli, staphylococcus aureus or candida albicans, then placing a sample solution containing bacterial liquid in a shaking table, shaking for 30min at the speed of 150r/min, sucking 1ml of the mixed solution after the shaking for uniformly coating the mixed solution on a culture medium, and placing the mixed solution in an incubator at 36 +/-1 ℃ for culturing for 48h while performing blank control.
The hydrocolloid dressing of example 1 was tested for liquid absorption properties: the dressing was pressed to a sheet thickness of 1mm and subsequently a 25mm by 25mm sample was punched and adhered to a slide (second hydrocolloid layer in contact with slide) and its mass was measured and recorded as m1。
To be provided with a sampleSlides were placed in a beaker of 0.9% isotonic saline at 37 ℃. After 24h, the slide was removed from the beaker and suspended in the air for 30s, and the mass m was again weighed after the surface of the slide not covered by the dressing had dried2. The increase in mass was recorded as the water uptake.
Table 1 shows the results of the antimicrobial test of hydrocolloid dressings
Table 2 shows the results of the liquid absorption performance test of hydrocolloid dressing
Sample (I) | m1/g | m2/g | Liquid absorption amount g/m2 |
Parallel experiment one | 4.576 | 7.015 | 3902 |
|
4.937 | 7.522 | 4136 |
Competition product | 3.501 | 5.382 | 3010 |
The hydrocolloid dressing has broad-spectrum antibacterial effect, and 4000g/m2Excellent liquid-absorbing performance.
In conclusion, the technical scheme provided by the invention overcomes the defects in the prior art, successfully completes the invention task and truly realizes the technical effects of the applicant in the technical effect column.
Claims (10)
1. The utility model provides a hydrocolloid dressing, its characterized in that includes first hydrocolloid layer I (1), combines in a second hydrocolloid layer II (2) of first hydrocolloid layer I (1) one side up and combines in back sheet (3) of second hydrocolloid layer II (2) one side up of orientation first hydrocolloid layer I (1) one side up distributes with interval state has seepage liquid anti-return lock water mechanism (11) to one side up, and second hydrocolloid layer II (2) one side down constitutes there is hydrocolloid laminating reinforcing mechanism (21).
2. Hydrocolloid dressing according to claim 1, characterized in that the liquid-permeable, backflow-preventing and water-locking means (11) is a water-locking cavity-building tongue (111) formed at a spacing on the side of the first hydrocolloid layer i (1) facing upwards, the recessed area formed by the wound-permeable liquid-locking cavity-building tongue (111) being folded over with respect to the first hydrocolloid layer i (1) constitutes a water-locking cavity (112), the depth of the water-locking cavity (112) being equal to the thickness of the water-locking cavity-building tongue (111) and the shape and size of the water-locking cavity (112) being the same as the water-locking cavity-building tongue (111), the depth of the water-locking cavity (112) being one third or two fifths of the thickness of the first hydrocolloid layer i (1); the hydrocolloid adhesion enhancing mechanism (21) is a groove (211) formed in one downward side of the second hydrocolloid layer II (2), and the depth of the groove (211) is one third or two fifths of the thickness of the second hydrocolloid layer II (2).
3. Hydrocolloid dressing according to claim 1 or 2, characterized in that the thickness of the first hydrocolloid layer i (1) is 0.5-1.0 mm; the thickness of the second hydrocolloid layer II (2) is 1-5 mm.
4. The hydrocolloid dressing according to claim 1, characterized in that the first hydrocolloid layer i (1) comprises the following raw materials in percentage by mass: 13-20% of polystyrene-polyisoprene block copolymer, 25-35% of tackifying resin, 13-20% of naphthenic oil, 25-40% of sodium carboxymethyl cellulose, 8-12% of cross-linked sodium carboxymethyl cellulose and 1-2% of antibacterial ceramic powder; the second hydrogel layer II (2) is prepared from the following raw materials in percentage by mass: 13-20% of polystyrene-polyisoprene block copolymer, 25-35% of tackifying resin, 14-20% of naphthenic oil, 25-40% of sodium carboxymethyl cellulose and 8-12% of cross-linked sodium carboxymethyl cellulose.
5. Hydrocolloid dressing according to claim 1, characterized in that the backing layer (3) is a polyurethane film or a silicone film.
6. Hydrocolloid dressing according to claim 2, characterized in that the shape of the water-locking chamber (112) is any one or combination of V-shape, prismatic shape, triangular shape, U-shape, n-shape, Jiong-shape and C-shape; the shape of the groove (211) is any one or combination of a plurality of shapes of a # shape, a circular shape, a cross criss-cross shape, a plurality of zigzag shapes, a saw tooth shape and a polygon.
7. Hydrocolloid dressing according to claim 4, characterized in that the antibacterial ceramic powder is titanium dioxide photocatalytic antibacterial ceramic powder and/or silver-based antibacterial ceramic powder.
8. A method of preparing hydrocolloid dressing according to claim 1, characterized in that it comprises the following steps:
A) preparing a first hydrogel layer I (1), and preparing the following raw materials in percentage by mass: 13-20% of polystyrene-polyisoprene block copolymer, 25-35% of tackifying resin, 13-20% of naphthenic oil, 25-40% of sodium carboxymethylcellulose, 8-12% of cross-linked sodium carboxymethylcellulose and 1-2% of antibacterial ceramic powder, introducing 13-20% of polystyrene-polyisoprene block copolymer, 25-35% of tackifying resin and 13-20% of naphthenic oil into a vacuum stirrer to mix, controlling the stirring time of the vacuum stirrer and the stirring temperature of the vacuum stirrer to obtain a first mixture, then uniformly mixing 25-40% of sodium carboxymethylcellulose, 8-12% of cross-linked sodium carboxymethylcellulose and 1-2% of antibacterial ceramic powder at normal temperature to obtain a second mixture, then adding the second mixture into the first mixture to continue stirring, controlling the time of continuing stirring and controlling the temperature of continuing stirring, discharging after continuously stirring, coating the material on release paper (4), cutting the material together with the release paper (4) to obtain a first hydrocolloid layer I (1), and forming seepage backflow-preventing water locking mechanisms (11) distributed at intervals on the upward side of the first hydrocolloid layer I (1) by using a tool;
B) preparing a second hydrocolloid layer II (2), and preparing the following raw materials in percentage by mass: 13-20% of polystyrene-polyisoprene block copolymer, 25-35% of tackifying resin, 14-20% of naphthenic oil, 25-40% of sodium carboxymethylcellulose and 8-12% of crosslinked sodium carboxymethylcellulose, then 13-20% of polystyrene-polyisoprene block copolymer, 25-35% of tackifying resin and 14-20% of naphthenic oil are put into a vacuum stirrer to be uniformly mixed, the stirring time of the vacuum stirrer and the stirring temperature of the vacuum stirrer are controlled to obtain a first uniform mixture, then 25-40% of sodium carboxymethylcellulose and 8-12% of crosslinked sodium carboxymethylcellulose are uniformly mixed at normal temperature to obtain a second uniform mixture, then the second uniform mixture is added into the first uniform mixture to be stirred, the subsequent stirring time and the subsequent stirring temperature are controlled, and (2) obtaining a material to be pressed, pressing the material to be pressed into a block by using a pressing tool, wherein the surface area of one side, facing the first hydrocolloid layer I (1), of the block is the same as the surface area of one side, facing the first hydrocolloid layer I (1), of the block, so that a second hydrocolloid layer II (2) is obtained, a hydrocolloid adhesion enhancing mechanism (21) is formed on one side, facing the lower part, of the second hydrocolloid layer II (2), and finally, the side, facing the lower part, of the second hydrocolloid layer II (2) is superposed on the side, facing the upper part, of the first hydrocolloid layer I (1), so that the seepage liquid backflow preventing and water locking mechanism (11) and the hydrocolloid adhesion enhancing mechanism (21) are combined with each other, and a back lining layer (3) covers the surface of one side, facing the upper part, of the second hydrocolloid layer II (2), so that the hydrocolloid dressing is obtained.
9. The method for preparing hydrocolloid dressing according to claim 8, characterized in that the stirring time of the vacuum stirrer in step a) is controlled to be 55-65min, and the stirring temperature of the vacuum stirrer is controlled to be 175-185 ℃; the time for controlling the continuous stirring is controlled to be 30-40min, and the temperature for controlling the continuous stirring is controlled to be 175-185 ℃.
10. The method for preparing hydrocolloid dressing according to claim 8, characterized in that the stirring time of the vacuum stirrer in step B) is controlled to be 55-65min, and the stirring temperature of the vacuum stirrer is controlled to be 175-180 ℃; the time for controlling the subsequent stirring is controlled to be 30-40min, and the temperature for controlling the subsequent stirring is controlled to be 175-185 ℃.
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