CN112315515A - Sampling mechanism for cell detection - Google Patents
Sampling mechanism for cell detection Download PDFInfo
- Publication number
- CN112315515A CN112315515A CN202011223220.2A CN202011223220A CN112315515A CN 112315515 A CN112315515 A CN 112315515A CN 202011223220 A CN202011223220 A CN 202011223220A CN 112315515 A CN112315515 A CN 112315515A
- Authority
- CN
- China
- Prior art keywords
- block
- rod
- movable
- fixed
- piece
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000005070 sampling Methods 0.000 title claims abstract description 24
- 238000001514 detection method Methods 0.000 title claims abstract description 14
- 230000007246 mechanism Effects 0.000 title claims abstract description 14
- 210000000214 mouth Anatomy 0.000 claims abstract description 22
- 210000004027 cell Anatomy 0.000 claims abstract description 21
- 238000007790 scraping Methods 0.000 claims abstract description 20
- 241001465754 Metazoa Species 0.000 claims abstract description 9
- 210000002919 epithelial cell Anatomy 0.000 claims abstract description 4
- 238000007493 shaping process Methods 0.000 claims abstract description 4
- 230000000694 effects Effects 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 239000012535 impurity Substances 0.000 claims description 4
- 230000003044 adaptive effect Effects 0.000 claims 1
- 230000000149 penetrating effect Effects 0.000 claims 1
- 230000009471 action Effects 0.000 abstract description 8
- 238000000605 extraction Methods 0.000 abstract description 6
- 238000003825 pressing Methods 0.000 abstract description 2
- 238000003860 storage Methods 0.000 abstract description 2
- 230000000669 biting effect Effects 0.000 description 6
- 230000008569 process Effects 0.000 description 3
- 238000010171 animal model Methods 0.000 description 2
- 238000010030 laminating Methods 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000006727 cell loss Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D15/00—Mouth openers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/40—Animals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention discloses a sampling mechanism for cell detection, which comprises a baffle plate, wherein a sampling main plate is arranged in the middle of the baffle plate, a scraping block assembly which can scrape and extract epithelial cells in an oral cavity back and forth is arranged on one side of the sampling main plate, the scraping block can be automatically occluded by a small animal, the scraping block is tightly pressed on the side of the oral cavity to ensure sufficient cell extraction, a movable handle is pulled back and forth, a sleeve rod drives the scraping block to reciprocate back and forth, the scraping block is matched with the left and right pressing action of an occlusion block to complete the sufficient cell extraction, and the scraping block and a test rod can be tightly and accurately inserted into a test tube bottle to form a fixing action by arranging a shaping clamping block which is matched with the diameter of the opening of the test tube and matching with a guide block to conveniently pull out the test rod from a limiting block to complete storage work.
Description
Technical Field
The invention relates to the technical field of cell sampling, in particular to a sampling mechanism for cell detection.
Background
The cell is the basic structure and functional unit of organism, and animal oral cavity sampling is the common operation of carrying out the analysis to experimental animal model, but when animal oral cavity sampling cell, experimental animal usually will be instinctive to bite the sampling tool in the mouth, makes the extraction work inconvenient, for this reason, we propose a sampling mechanism for cell detection.
Disclosure of Invention
The present invention is directed to a sampling mechanism for cell detection, which solves the above problems of the prior art.
In order to achieve the purpose, the invention provides the following technical scheme: the utility model provides a sampling mechanism for cell detection, includes the baffle of avoiding impurity pollution sample site on tongue and the tooth, the baffle middle part is equipped with the sample mainboard of being convenient for draw the interlock of in-process animal, the sample mainboard is close to oral cavity avris and is equipped with the piece group spare of scraping of being convenient for to make a round trip to wipe and draw oral cavity epithelial cells.
Preferably, the sample mainboard includes and is connected fixed block fixed with the baffle, the fixed block is inside to be symmetrical structure swing joint about being two and passes the piece is stung to the fixed block surface, two sting to be equipped with between the piece with the fixed block internal connection fixed limiting plate, the limiting plate with sting to articulate the cooperation between the piece and have the spring, the right-hand movable block that is equipped with of limiting plate, the movable block with sting a pressfitting activity, movable block top right side is the chute structure.
Preferably, scrape the movable rod of block subassembly including passing the fixed block, movable rod rear end and movable block pressfitting activity, movable rod front end clearance fit has the slide bar, movable rod the place ahead is equipped with inside hollow stopper, the sliding tray has been seted up to the stopper rear side, the slide bar left end passes the sliding tray and gets into inside and fixedly connected with slider of limiting groove, slider the place ahead is equipped with and wipes away the excellent pole with stopper sliding fit, it is fixed with the design fixture block to wipe away excellent pole middle part and be symmetrical structural connection, it is equipped with the piece of scraping of seting up a plurality of collection notches to wipe away excellent pole right-hand member, it is equipped with the guide block of being connected fixedly with the stopper to scrape the piece below, stopper front side fixedly connected with loop bar, loop bar middle part cover is equipped with and is connected fixed sleeve with the fixed block, loop bar front end fixedly connected with movable.
Preferably, the right part of the inner side of the biting block is in an inclined shape, the right part of the inner side of the biting block is matched with the right end of the movable block in shape, and the front end of the sliding rod is in a structure matched with the right side of the top of the movable block.
Preferably, the baffle is shaped to conform to the interior of the mouth.
Preferably, two distance between the design fixture block left end is unanimous with test tube bottle diameter size.
Compared with the prior art, the invention has the beneficial effects that:
1. according to the invention, the biting block is occluded by the teeth of the small animal, the biting block is pressed on the movable block, the movable rod extends towards the right side to drive the scraping block to jack towards the right side, the scraping block extends out of the stop block, the scraping block is tightly pressed on the side of the oral cavity, the situation that a sampling person continuously forces the small animal to open the mouth to complete extraction is avoided, the stop block which is in a shape matched with the interior of the oral cavity can avoid the interference of the teeth and the tongue on cell extraction, and the extracted cells are ensured not to be interfered by other impurities.
2. According to the invention, the movable handle is pulled back and forth by an extractor, so that the loop bar drives the scraping block to do reciprocating motion back and forth, the biting action of small animals is matched, the left and right direction pressing action of the biting block is continuously performed, the cell is fully extracted, the scraping block and the test rod bar can be tightly and accurately inserted into the test tube bottle to form a fixing action by arranging the sizing clamping block which is matched with the diameter of the test tube bottle and matching with the guide block, the scraping block and the test rod bar are conveniently pulled out from the limiting block to complete the storage work, in addition, the scraping block cannot touch the inner wall of the test tube bottle in the whole process, the unnecessary cell loss is avoided, the mode is simple to operate, and the extraction effect is.
Drawings
FIG. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a right-side view of the overall structure of the present invention;
FIG. 3 is a left side sectional view of the sampling main board structure according to the present invention;
FIG. 4 is a schematic top sectional view of a sampling main board structure according to the present invention;
FIG. 5 is a partial schematic view of the present invention;
fig. 6 is a cross-sectional view of the partial structure of fig. 5.
In the figure: 1-a baffle plate; 2-sampling the mainboard; 3, fixing blocks; 4-biting blocks; 5-a limiting plate; 6-a spring; 7-a movable block; 8-a wiper block assembly; 9-a movable rod; 10-a slide bar; 11-a limiting block; 12-a sliding groove; 13-a slide block; 14-a swab bar; 15-shaping fixture blocks; 16-a scraping block; 17-a guide block; 18-a loop bar; 19-a sleeve; 20-movable handle.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-6, the present invention provides a technical solution: the utility model provides a sampling mechanism for cell detection, includes baffle 1 that avoids impurity pollution sample position on tongue and the tooth, 1 middle part of baffle is equipped with the sample mainboard 2 of being convenient for draw the interlock of in-process animal, sample mainboard 2 is close to oral cavity avris and is equipped with the scraping block group spare 8 of being convenient for make a round trip to scrape and draw oral cavity epithelial cell.
The scraper block component 8 comprises a movable rod 9 passing through a fixed block 3, the rear end of the movable rod 9 is in press fit with a movable block 7, the front end of the movable rod 9 is movably matched with a slide rod 10, a hollow limiting block 11 is arranged in front of the movable rod 9, a slide groove 12 is arranged at the rear end of the limiting block 11, the left end of the slide rod 10 passes through the slide groove 12 to enter the limiting groove and be fixedly connected with a slide block 13, a rod 14 sliding matched with the limiting block 11 is arranged in front of the slide block 13, the middle part of the rod 14 is symmetrically connected and fixed with a shaping fixture block 15, the right end of the rod 14 is provided with a scraper block 16 provided with a plurality of collecting notches, a guide block 17 fixedly connected with the limiting block 11 is arranged below the scraper block 16, a sleeve 18 is fixedly connected with the front side of the limiting block 11, and a sleeve 19 fixedly connected with the fixed block 3 is sleeved in, the utility model discloses a cleaning device, including loop bar 18, stopper 11, movable rod 9, stopper 11, movable rod 10, stopper 11, movable rod 18, the front end fixedly connected with movable handle 20 of loop bar front end, movable rod 9 drives slide bar 10, stopper 11 makes and wipes away excellent pole 14 and extrudees to the oral cavity avris to scrape 16 laminating oral cavity avris, again through manual pull movable handle 20 that makes a round trip, make loop bar 18 drive stopper 11, wipe away excellent pole 14 and do the reciprocal wiping movement of making a round trip around, and the interlock effect that lasts of cooperation toy, scrape the effect of 16 lasting pressfitting oral cavity avris of piece.
Sting 4 inboard right parts of piece and being the slope shape, sting 4 inboard right parts of piece and being fit for with the 7 right-hand members shapes of movable block, slide bar 10 front end is the structure that suits with the 7 top right sides of movable block, through the structure of mutually supporting, accomplishes the extrusion effect, makes the accurate and oral cavity avris pressfitting of slide bar 10 front end.
The baffle 1 is shaped to fit inside the mouth to avoid interference of the teeth and tongue with the scraping block 16.
Two the distance is unanimous with test tube bottle diameter size between the 15 left ends of design fixture block, cooperation guide block 17 can make scrape 16 and test rod pole fastening accuracy form the fixed action in inserting the test tube bottle, conveniently pulls out the completion from stopper 11 and keeps the work with it.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. The utility model provides a sampling mechanism for cell detection, includes baffle (1) of avoiding impurity pollution sample site on tongue and the tooth, its characterized in that: baffle (1) middle part is equipped with sample mainboard (2) of being convenient for draw the interlock of in-process animal, sample mainboard (2) are close to the oral cavity avris and are equipped with the piece subassembly (8) of scraping of being convenient for to make a round trip to scrape and draw oral cavity epithelial cell.
2. The sampling mechanism for cell detection according to claim 1, wherein: sample mainboard (2) include and be connected fixed block (3) fixed with baffle (1), fixed block (3) inside be about symmetrical structure swing joint have two to pass block (4) are stung to fixed block (3) surface, two it is equipped with limiting plate (5) fixed with fixed block (3) internal connection to sting between piece (4), limiting plate (5) and sting the cooperation between piece (4) have spring (6), limiting plate (5) right-hand movable block (7) that are equipped with, movable block (7) and sting piece (4) pressfitting activity, movable block (7) top right side is the chute structure.
3. The sampling mechanism for cell detection according to claim 2, wherein: the scraper block assembly (8) comprises a movable rod (9) penetrating through a fixed block (3), the rear end of the movable rod (9) is in press fit with a movable block (7), a sliding rod (10) is movably matched with the front end of the movable rod (9), a hollow limiting block (11) is arranged in front of the movable rod (9), a sliding groove (12) is formed in the rear side of the limiting block (11), the left end of the sliding rod (10) penetrates through the sliding groove (12) to enter the limiting groove and is fixedly connected with a sliding block (13), a rod wiping rod (14) which is in sliding fit with the limiting block (11) is arranged in front of the sliding block (13), the middle of the rod wiping rod (14) is symmetrically connected and fixed with a shaping clamping block (15), a plurality of scraping blocks (16) for collecting notches are arranged at the right end of the rod wiping rod (14), and a guide block (17) which is fixedly connected with the limiting block (11) is arranged below the scraper, stopper (11) front side fixedly connected with loop bar (18), loop bar (18) middle part cover is equipped with and is connected fixed sleeve (19) with fixed block (3), loop bar (18) front end fixedly connected with movable handle (20).
4. The sampling mechanism for cell detection according to claim 3, wherein: sting the inboard right part of piece (4) and being the slope shape, sting the inboard right part of piece (4) and suiting with movable block (7) right-hand member shape, slide bar (10) front end is the structure that suits with movable block (7) top right side.
5. The sampling mechanism for cell detection according to claim 4, wherein: the baffle (1) is in a shape adaptive to the inside of the oral cavity.
6. The sampling mechanism for cell detection according to claim 5, wherein: two distance between design fixture block (15) the left end is unanimous with test tube bottle diameter size.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011223220.2A CN112315515A (en) | 2020-11-05 | 2020-11-05 | Sampling mechanism for cell detection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011223220.2A CN112315515A (en) | 2020-11-05 | 2020-11-05 | Sampling mechanism for cell detection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112315515A true CN112315515A (en) | 2021-02-05 |
Family
ID=74315728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011223220.2A Withdrawn CN112315515A (en) | 2020-11-05 | 2020-11-05 | Sampling mechanism for cell detection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112315515A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114280048A (en) * | 2021-12-28 | 2022-04-05 | 黄焕滨 | Disposable extracorporeal fast detecting reagent device |
-
2020
- 2020-11-05 CN CN202011223220.2A patent/CN112315515A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114280048A (en) * | 2021-12-28 | 2022-04-05 | 黄焕滨 | Disposable extracorporeal fast detecting reagent device |
| CN114280048B (en) * | 2021-12-28 | 2024-02-09 | 青岛市胶州中心医院 | Disposable in vitro rapid detection reagent device |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112315515A (en) | Sampling mechanism for cell detection | |
| US3626546A (en) | Attachment for a vacuum cleaner to comb the hair of pets | |
| CN212000831U (en) | Animal excrement pickup device for epidemic situation detection | |
| CN203885537U (en) | Cervical tissue biopsy forceps | |
| CN216775522U (en) | Jaboticaba collection device | |
| CN111000595A (en) | Cervical canal tissue sampler | |
| CN113647994A (en) | Auxiliary device for lung cancer methylation inspection | |
| CN213277625U (en) | Television wire harness branching machine | |
| CN214387532U (en) | Disposable cervical exfoliated cell autonomous sampler | |
| CN213883217U (en) | Poultry animal doctor is with blood sampling device | |
| CN212326460U (en) | Movable dermatological scraper with protective structure | |
| CN209490039U (en) | A kind of biopsy forceps | |
| CN213779626U (en) | Zeolite amino acid shampoo sampling device | |
| CN221331557U (en) | Cow superrow oocyte extraction device convenient to clearance | |
| CN209136490U (en) | The dustpan of cleanable combing broom | |
| CN217853060U (en) | Novel oral swab | |
| CN215503168U (en) | Biopsy forceps convenient to operate | |
| CN219182424U (en) | Animal hair scraping device | |
| CN218550944U (en) | Baffle scraping type hair collecting and combing device | |
| CN109123985A (en) | A kind of anti-pickup comb of densely covered formula | |
| CN220477136U (en) | Electric flushing and sucking type mouth protecting toothbrush | |
| CN215721494U (en) | Filling pipeline connection structure for agar | |
| CN218660568U (en) | Cotton stick production former | |
| CN218797533U (en) | Sealing door of pulsation vacuum sterilizer | |
| CN221615888U (en) | Pet cage convenient to clean |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20210205 |
|
| WW01 | Invention patent application withdrawn after publication |