CN112300083A - Preparation method of Favipiravir - Google Patents
Preparation method of Favipiravir Download PDFInfo
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- CN112300083A CN112300083A CN202010313438.0A CN202010313438A CN112300083A CN 112300083 A CN112300083 A CN 112300083A CN 202010313438 A CN202010313438 A CN 202010313438A CN 112300083 A CN112300083 A CN 112300083A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
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Claims (11)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN202010313438.0A CN112300083B (en) | 2020-04-20 | 2020-04-20 | Preparation method of Favipiravir |
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CN202010313438.0A CN112300083B (en) | 2020-04-20 | 2020-04-20 | Preparation method of Favipiravir |
Publications (2)
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CN112300083A true CN112300083A (en) | 2021-02-02 |
CN112300083B CN112300083B (en) | 2021-08-03 |
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CN202010313438.0A Active CN112300083B (en) | 2020-04-20 | 2020-04-20 | Preparation method of Favipiravir |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113072507A (en) * | 2021-03-18 | 2021-07-06 | 中国科学院上海有机化学研究所 | Preparation method of fluoropyrazine compound |
CN113234030A (en) * | 2021-04-29 | 2021-08-10 | 河北唯达生物医药产业技术研究有限公司 | Preparation method of 6-bromo-3-hydroxy-2-pyrazinecarboxamide |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1539828A (en) * | 1998-08-20 | 2004-10-27 | ��ɽ��ѧ��ҵ��ʽ���� | Nitrogen-contg. heterocyclic carboxamide derivatives or salt thereof |
CN1781911A (en) * | 2000-02-16 | 2006-06-07 | 富山化学工业株式会社 | Intermediate for producing novel pyrazine derivatives |
CN102603658A (en) * | 2011-10-18 | 2012-07-25 | 山东齐都药业有限公司 | Preparation method of 6-fluorine-3-hydroxyl-2-pyrazinamide |
CN102775358A (en) * | 2012-08-22 | 2012-11-14 | 山东齐都药业有限公司 | Preparation method of 6-fluoro-3-hydroxy-2-pyrazinamide |
CN104496917A (en) * | 2014-12-15 | 2015-04-08 | 南京华威医药科技开发有限公司 | Synthesis method of Favipiravir |
CN105732523A (en) * | 2014-12-10 | 2016-07-06 | 青岛市黄岛区中医医院 | Preparation method for 6-fluoro-3-hydroxyl-2-pyrazinamide |
CN106866553A (en) * | 2017-03-28 | 2017-06-20 | 中南大学 | A kind of synthetic method of Favipiravir |
-
2020
- 2020-04-20 CN CN202010313438.0A patent/CN112300083B/en active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1539828A (en) * | 1998-08-20 | 2004-10-27 | ��ɽ��ѧ��ҵ��ʽ���� | Nitrogen-contg. heterocyclic carboxamide derivatives or salt thereof |
CN1781911A (en) * | 2000-02-16 | 2006-06-07 | 富山化学工业株式会社 | Intermediate for producing novel pyrazine derivatives |
CN102603658A (en) * | 2011-10-18 | 2012-07-25 | 山东齐都药业有限公司 | Preparation method of 6-fluorine-3-hydroxyl-2-pyrazinamide |
CN102775358A (en) * | 2012-08-22 | 2012-11-14 | 山东齐都药业有限公司 | Preparation method of 6-fluoro-3-hydroxy-2-pyrazinamide |
CN105732523A (en) * | 2014-12-10 | 2016-07-06 | 青岛市黄岛区中医医院 | Preparation method for 6-fluoro-3-hydroxyl-2-pyrazinamide |
CN104496917A (en) * | 2014-12-15 | 2015-04-08 | 南京华威医药科技开发有限公司 | Synthesis method of Favipiravir |
CN106866553A (en) * | 2017-03-28 | 2017-06-20 | 中南大学 | A kind of synthetic method of Favipiravir |
Non-Patent Citations (5)
Title |
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FANGYUAN SHI等: "Synthesis and crystal structure of 6-fluoro-3-hydroxypyrazine-2-carboxamide", 《DRUG DISCOVERIES & THERAPEUTICS》 * |
刘涛等: "法匹拉韦合成路线图解", 《中国药物化学杂志》 * |
杨柳: "法匹拉韦的合成工艺研究", 《济南大学硕士学位论文》 * |
王皖: "法匹拉韦及赛红霉素中间体的合成研究", 《延边大学硕士学位论文》 * |
石川延男: "《含氟生理活性物质的开发和应用》", 31 December 2000, 华东理工大学出版社 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113072507A (en) * | 2021-03-18 | 2021-07-06 | 中国科学院上海有机化学研究所 | Preparation method of fluoropyrazine compound |
CN113072507B (en) * | 2021-03-18 | 2022-09-13 | 中国科学院上海有机化学研究所 | Preparation method of fluoropyrazine compound |
CN113234030A (en) * | 2021-04-29 | 2021-08-10 | 河北唯达生物医药产业技术研究有限公司 | Preparation method of 6-bromo-3-hydroxy-2-pyrazinecarboxamide |
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Inventor after: Yu Liguo Inventor after: Ma Guanjun Inventor after: Zhang Yunran Inventor after: Zhou Fuchao Inventor after: Xia Chao Inventor after: Liu Chao Inventor after: Sun Guangxiang Inventor after: Tang Jingyuan Inventor before: Ma Guanjun Inventor before: Zhang Yunran Inventor before: Zhou Fuchao Inventor before: Xia Chao Inventor before: Liu Chao Inventor before: Sun Guangxiang Inventor before: Tang Jingyuan |
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