CN112294498A - Cobalt alloy partition bone trabecula femur condyle prosthesis and preparation method thereof - Google Patents
Cobalt alloy partition bone trabecula femur condyle prosthesis and preparation method thereof Download PDFInfo
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- CN112294498A CN112294498A CN202011195215.5A CN202011195215A CN112294498A CN 112294498 A CN112294498 A CN 112294498A CN 202011195215 A CN202011195215 A CN 202011195215A CN 112294498 A CN112294498 A CN 112294498A
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- 238000005192 partition Methods 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 210000000689 upper leg Anatomy 0.000 title claims abstract description 9
- 239000013067 intermediate product Substances 0.000 claims abstract description 56
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- 238000001513 hot isostatic pressing Methods 0.000 claims abstract description 6
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- 238000010438 heat treatment Methods 0.000 claims description 25
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 20
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 10
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 8
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- 229910052786 argon Inorganic materials 0.000 claims description 4
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- 229910052734 helium Inorganic materials 0.000 claims description 3
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 claims description 3
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- 208000003241 Fat Embolism Diseases 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/38—Joints for elbows or knees
- A61F2/3859—Femoral components
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
- B22F3/12—Both compacting and sintering
- B22F3/14—Both compacting and sintering simultaneously
- B22F3/15—Hot isostatic pressing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
- B22F3/24—After-treatment of workpieces or articles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F5/00—Manufacture of workpieces or articles from metallic powder characterised by the special shape of the product
- B22F5/10—Manufacture of workpieces or articles from metallic powder characterised by the special shape of the product of articles with cavities or holes, not otherwise provided for in the preceding subgroups
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y40/00—Auxiliary operations or equipment, e.g. for material handling
- B33Y40/20—Post-treatment, e.g. curing, coating or polishing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y70/00—Materials specially adapted for additive manufacturing
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- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C19/00—Alloys based on nickel or cobalt
- C22C19/07—Alloys based on nickel or cobalt based on cobalt
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2002/3093—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth for promoting ingrowth of bone tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2002/30934—Special articulating surfaces
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00029—Cobalt-based alloys, e.g. Co-Cr alloys or Vitallium
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F3/00—Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sintering; Apparatus specially adapted therefor ; Presses and furnaces
- B22F3/24—After-treatment of workpieces or articles
- B22F2003/248—Thermal after-treatment
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- Mechanical Engineering (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Materials Engineering (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
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- Physical Education & Sports Medicine (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Prostheses (AREA)
Abstract
The invention discloses a cobalt alloy partition bone trabecula femur condyle prosthesis and a preparation method thereof, comprising the following steps: the cobalt alloy partitioned trabecular bone femoral condyle prosthesis is characterized in that cobalt alloy powder is used as a raw material, an intermediate product of the cobalt alloy partitioned trabecular bone femoral condyle prosthesis is obtained through 3D printing and integral forming, hot isostatic pressing and cryogenic treatment are carried out, and the trabecular bone is obtained through the cobalt alloy partitioned trabecular bone femoral condyle prosthesis, wherein the trabecular bone is arranged on the inner side condyle fixing surface and the outer side condyle fixing surface of the cobalt alloy partitioned trabecular bone femoral condyle prosthesis in a partitioned mode. The invention adopts 3D printing and integrated molding, has high bonding strength between the trabecula bone and the solid body, is not easy to fall off, and prolongs the service life of the prosthesis. The trabecular bone part of the cobalt alloy partitioned trabecular femoral condyle prosthesis prepared by the invention has excellent compression resistance; the solid part releases residual stress and plasticity is enhanced.
Description
Technical Field
The invention relates to the technical field of medical implant materials, in particular to a cobalt alloy zoned trabecular femoral condyle prosthesis and a preparation method thereof.
Background
Total knee replacement is currently an effective treatment mode for end-stage knee joint diseases in clinic, and the damaged knee joint tissue is replaced by an artificially designed joint prosthesis, so that pain of patients is relieved, the knee joint function of the patients is recovered, and the life quality of the patients is improved. Corresponding to the anatomical structure of human body, the knee joint prosthesis comprises a femoral condyle, a tibial plateau and a platform pad. With the rapid development of medical instrument technology and the continuous improvement of requirements of people on the safety and effectiveness of prosthesis products, the design and manufacturing technology of knee joint prostheses needs to be continuously optimized and improved.
Currently, clinically used knee prostheses include two major classes, bone cement type and biologic type (non-bone cement fixation). Wherein the bone cement type prosthesis mechanically fixes the joint prosthesis and the bone tissue by means of the solidification and filling of the bone cement. However, years of clinical application show that bone cement fixation can bring about a plurality of safety and effectiveness problems: the bone cement monomer is polymerized to release heat, so that surrounding tissues are damaged; bone cement particles, if introduced into the blood or during filling, cause high pressure in the medullary cavity, leading to pulmonary embolism and fat embolism.
The biological knee joint prosthesis can effectively eliminate the safety and effectiveness risks brought by bone cement, and generally utilizes a surface porous structure to promote bone ingrowth so as to obtain long-term stability. But the surface porous structure is usually prepared by surface treatment processes such as sand blasting, coating, sintering and the like, has low bonding strength with an entity, is easy to fall off, and reduces the service life of the prosthesis. And, according to Wolff's law: after the stress causes the bone to generate deformation (also called micro-strain), the original signal can be started to regulate the synthesis and the catabolism of the bone, and the strain range can promote the bone growth only between the minimum effective strain threshold and the supraphysiological strain threshold. Therefore, the femoral condyle prosthesis is designed, the micro-strain of most areas of bone tissues is realized between the minimum effective strain threshold and the supraphysiological strain threshold, the bone ingrowth is facilitated, and the femoral condyle prosthesis has important significance.
The 3D printing technology is used as an additive manufacturing technology, breaks through a product design concept facing a manufacturing process, realizes a product design concept facing performance, solves the problem that complex parts are difficult to integrally form, and reduces waste of raw materials and energy caused by machining and manufacturing. However, the solid part of the 3D printed product is easy to have the problems of uneven microstructure, internal defects and the like, and the mechanical property is poor; the powder in the trabecular bone part structure cannot be well sintered, and the mechanical property is poor. Therefore, the preparation of the cobalt alloy partition bone trabecula femur condyle prosthesis with excellent mechanical property and osseointegration property has important significance.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a cobalt alloy zoned trabecular femoral condyle prosthesis.
The second purpose of the invention is to provide a preparation method of the cobalt alloy zoned trabecular femoral condyle prosthesis.
The technical scheme of the invention is summarized as follows:
the preparation method of the cobalt alloy zoned trabecular femoral condyle prosthesis comprises the following steps:
1) taking cobalt alloy powder as a raw material, carrying out 3D printing and integral forming to obtain a first intermediate product of the cobalt alloy zoned bone trabecula femur condyle prosthesis, putting the first intermediate product into a hot isostatic pressing furnace, heating to 1140-1200 ℃ under the protection of helium or argon, standing for 1-3 h at a constant temperature of 110-170 MPa, reducing to normal pressure, cooling to below 200 ℃ along with the furnace, and taking out to obtain a second intermediate product:
2) placing the second intermediate product in a programmed cooling box, cooling to-80-120 ℃ at the speed of 1 ℃/min, placing at constant temperature for 5-10 h, and taking out from the programmed cooling box; placing the mixture in liquid nitrogen for 16-36 h, and adjusting the temperature to room temperature to obtain a third intermediate product;
3) placing the third intermediate product in a programmed cooling box, cooling to-80 to-120 ℃ at the speed of 1 ℃/min, and placing for 5 to 10 hours at constant temperature; taking out the box from the programmed cooling box; placing in liquid nitrogen for 16-36 h, and adjusting the temperature to room temperature; obtaining a fourth intermediate product, and performing machining and trimming to obtain a cobalt alloy partitioned trabecular femoral condyle prosthesis;
the first intermediate product, the second intermediate product, the third intermediate product and the fourth intermediate product of the cobalt alloy partition trabecular femoral condyle prosthesis have the same structures as the cobalt alloy partition trabecular femoral condyle prosthesis.
The cobalt alloy partition trabecular bone femoral condyle prosthesis structure comprises a medial condyle 11 and a lateral condyle 12 which are arranged on the left and right sides, wherein a medial condyle front end 1101 of the medial condyle 11 and a lateral condyle front end 1102 of the lateral condyle 12 are integrated, and a rear end of the medial condyle 11 is connected with a rear end of the lateral condyle 12 through a limit stop 15; the lateral wall of the medial condyle 11 and the lateral wall of the lateral condyle 12 are both provided with holding grooves 16, the medial condyle 11 is provided with a medial condyle fixing surface 110, and the lateral condyle is provided with a lateral condyle fixing surface 120; the medial condyle fixing surface 110 comprises a first fixing surface 111, a second fixing surface 112, a third fixing surface 113, a fourth fixing surface 114 and a fifth fixing surface 115 which are connected in sequence, and the lateral condyle fixing surface 120 comprises a sixth fixing surface 121, a seventh fixing surface 122, an eighth fixing surface 123, a ninth fixing surface 124 and a tenth fixing surface 125 which are connected in sequence; the middle parts of the third fixing surface 113 and the eighth fixing surface 123 are provided with mounting holes 17, and the first fixing surface 111 and the second fixing surface 112 intersect to form a first intersection line 181; the second fixing surface 112 and the third fixing surface 113 intersect to form a second intersection line 182; the third fixing surface 113 and the fourth fixing surface 114 intersect to form a third intersection line 183; the fourth fixing surface 114 and the fifth fixing surface 115 form a fourth intersection line 184; the intersection line of the sixth fixing surface 121 and the seventh fixing surface 122 is collinear with the first intersection line 181; the intersection line of the seventh fixing surface 122 and the eighth fixing surface 123 is collinear with the second intersection line 182; the intersection line of the eighth fixing surface 123 and the ninth fixing surface 124 is collinear with the third intersection line 183; the line of intersection of the ninth fixation surface 124 and the tenth fixation surface 125 is collinear with the fourth line of intersection 184; the first intersection line 181, the second intersection line 182, the third intersection line 183 and the fourth intersection line 184 are parallel to each other;
the included angle between the first fixing surface 111 and the second fixing surface 112 is equal to the included angle between the sixth fixing surface 121 and the seventh fixing surface 122, and is 130-140 degrees; the included angle between the second fixing surface 112 and the third fixing surface 113 is equal to the included angle between the seventh fixing surface 122 and the eighth fixing surface 123, and is 130-140 degrees; the included angle between the third fixing surface 113 and the fourth fixing surface 114 is equal to the included angle between the eighth fixing surface 123 and the ninth fixing surface 124, and is 130-140 degrees; the included angle between the fourth fixing surface 114 and the fifth fixing surface 115 is equal to the included angle between the ninth fixing surface 124 and the tenth fixing surface 125, and is 130-140 degrees;
the first fixing surface 111, the fifth fixing surface 115, the sixth fixing surface 121 and the tenth fixing surface 125 are provided with a first bone trabecula 191;
the second fixing surface 112, the fourth fixing surface 114, the seventh fixing surface 122 and the ninth fixing surface 124 are provided with second bone trabeculae 192;
the third fixing surface 113 and the eighth fixing surface 123 are provided with a third trabecula 193;
the first trabecular bone 191 has a smaller pore size and porosity than the second 192 and third 193 trabecular bone in turn.
The cobalt alloy powder comprises, by mass, 59% -68% of Co, 26.5% -30.0% of Cr, 4.5% -7.0% of Mo, and the balance unavoidable trace impurities; the particle size of the cobalt alloy powder is 45-106 μm.
The steps 2) and 3) of adjusting the temperature are as follows: heating to-120 to-80 ℃, and keeping the temperature for 3 to 5 hours; heating to-40 to-20 ℃, and keeping the temperature for 3 to 5 hours; heating to 4-8 deg.c, maintaining for 1-3 hr, and heating.
Preferably, the first bone trabecula 191 has a pore diameter of 0.74mm to 0.85mm, a porosity of 70.0% to 74.7%, and a through porosity of 100%;
the aperture of the second bone trabecula 192 is 0.86mm-0.99mm, the porosity is 74.8% -77.5%, and the through porosity is 100%;
the third trabecula 193 has the aperture of 1.00-1.10 mm, the porosity of 77.6-85% and the through-hole rate of 100%.
The first, second and third bone trabeculae 191, 192 and 193 are of equal thickness, 0.5mm-3 mm.
A rectangular first solid structure 21 is arranged at the joint of the second fixing surface and the seventh fixing surface; the joint of the first fixing surface and the sixth fixing surface is provided with a semicircular second solid structure 20, and the thickness of the first solid structure 21 and the thickness of the second solid structure 20 are equal to the thickness of the trabecula and are 0.5mm-3 mm.
The first solid structure 21 and the second solid structure 20 can limit the included angle between the fourth fixing surface and the fifth fixing surface and the included angle between the ninth fixing surface and the tenth fixing surface from becoming larger in the process.
Preferably, the side walls 22 are provided at the edges of the fixation surfaces formed by the medial condyle fixation surface 110, the lateral condyle fixation surface 120 and the positive stop 15.
The cobalt alloy zoned trabecular femoral condyle prosthesis prepared by the method.
The invention has the following beneficial effects:
the cobalt alloy zoned trabecular femoral condyle prosthesis provided by the invention realizes that the micro-strain of most areas of the femoral condyle bone tissue is between the minimum effective strain threshold and the super-physiological strain threshold, thereby facilitating bone ingrowth and improving long-term stability.
The invention adopts 3D printing and integrated molding, has high bonding strength between the trabecula bone and the solid body, is not easy to fall off, and prolongs the service life of the prosthesis.
The trabecular bone part of the cobalt alloy partitioned trabecular femoral condyle prosthesis prepared by the invention has excellent compression resistance; the solid part releases residual stress and plasticity is enhanced.
Drawings
FIG. 1 is an isometric view of a cobalt alloy zoned trabecular femoral condyle prosthesis of the present invention as viewed from the lateral condyle.
FIG. 2 is an isometric view of a cobalt alloy zoned trabecular femoral condyle prosthesis (including a first solid structure, a second solid structure) of the present invention viewed from the medial condyle.
FIG. 3 is an isometric view of a cobalt alloy zoned trabecular femoral condyle prosthesis of the present invention from the anterior femoral condyle.
FIG. 4 is a strain cloud for finite element analysis of the cobalt alloy zoned trabecular femoral condyle prosthesis of example 1 viewed from the anterior femoral condyle.
FIG. 5 is a strain cloud for finite element analysis of the cobalt alloy zoned trabecular femoral condyle prosthesis of example 1 viewed from the posterior aspect of the femoral condyle.
Fig. 6 is an SEM image of trabecular bone in control group 1.
Fig. 7 is an SEM image of trabeculae of example 1.
FIG. 8 is a metallographic microstructure of a femoral condyle prosthesis of control 1.
FIG. 9 is a metallographic microstructure of the cobalt alloy zoned trabecular femoral condyle prosthesis of example 1.
Detailed Description
The invention relates to a cobalt alloy partition trabecular bone femoral condyle prosthesis which is integrally formed by 3D printing.
The invention is further described below with reference to the figures and examples.
Example 1
The preparation method of the cobalt alloy zoned trabecular femoral condyle prosthesis comprises the following steps:
1) taking cobalt alloy powder as a raw material, carrying out 3D printing and integral forming to obtain a first intermediate product of the cobalt alloy partitioned trabecular bone femoral condyle prosthesis, putting the first intermediate product into a hot isostatic pressing furnace, heating to 1140 ℃ under the protection of argon, standing at 170MPa for 3h at constant temperature, reducing to normal pressure, cooling to below 200 ℃ along with the furnace, taking out to obtain a second intermediate product:
2) placing the second intermediate product in a programmed cooling box, cooling to-80 ℃ at the speed of 1 ℃/min, placing at constant temperature for 10h, and taking out from the programmed cooling box; placing in liquid nitrogen for 16h, and adjusting the temperature to room temperature to obtain a third intermediate product;
3) placing the third intermediate product in a programmed cooling box, cooling to-80 ℃ at the speed of 1 ℃/min, and placing for 10h at constant temperature; taking out the box from the programmed cooling box; placing in liquid nitrogen for 16h, and adjusting the temperature to room temperature; obtaining a fourth intermediate product, and performing machining trimming to obtain a cobalt alloy partitioned trabecular femoral condyle prosthesis;
the cobalt alloy powder comprises 68% of Co, 26.5% of Cr, 4.5% of Mo and the balance of inevitable trace impurities by mass percent; the cobalt alloy powder had a particle size of 45 μm to 106 μm and was purchased from Acram, Sweden.
The steps 2) and 3) of adjusting the temperature are as follows: heating to-120 deg.C, and maintaining at constant temperature for 5 hr; heating to-40 deg.C, and maintaining at constant temperature for 5 hr; heating to 4 deg.C, maintaining at constant temperature for 3 hr, and heating.
The cobalt alloy segmented trabecular femoral condyle prosthesis structure (see figures 1-3) comprises a medial condyle 11 and a lateral condyle 12 which are arranged on the left and right, wherein a medial condyle front end 1101 of the medial condyle 11 and a lateral condyle front end 1102 of the lateral condyle 12 are integrated, and a rear end of the medial condyle 11 is connected with a rear end of the lateral condyle 12 through a limit stop 15; the lateral wall of the medial condyle 11 and the lateral wall of the lateral condyle 12 are both provided with holding grooves 16, the medial condyle 11 is provided with a medial condyle fixing surface 110, and the lateral condyle is provided with a lateral condyle fixing surface 120; the medial condyle fixing surface 110 comprises a first fixing surface 111, a second fixing surface 112, a third fixing surface 113, a fourth fixing surface 114 and a fifth fixing surface 115 which are connected in sequence, and the lateral condyle fixing surface 120 comprises a sixth fixing surface 121, a seventh fixing surface 122, an eighth fixing surface 123, a ninth fixing surface 124 and a tenth fixing surface 125 which are connected in sequence; the middle parts of the third fixing surface 113 and the eighth fixing surface 123 are provided with mounting holes 17, and the first fixing surface 111 and the second fixing surface 112 intersect to form a first intersection line 181; the second fixing surface 112 and the third fixing surface 113 intersect to form a second intersection line 182; the third fixing surface 113 and the fourth fixing surface 114 intersect to form a third intersection line 183; the fourth fixing surface 114 and the fifth fixing surface 115 form a fourth intersection line 184; the intersection line of the sixth fixing surface 121 and the seventh fixing surface 122 is collinear with the first intersection line 181; the intersection line of the seventh fixing surface 122 and the eighth fixing surface 123 is collinear with the second intersection line 182; the intersection line of the eighth fixing surface 123 and the ninth fixing surface 124 is collinear with the third intersection line 183; the line of intersection of the ninth fixation surface 124 and the tenth fixation surface 125 is collinear with the fourth line of intersection 184; the first intersection line 181, the second intersection line 182, the third intersection line 183 and the fourth intersection line 184 are parallel to each other;
the included angle between the first fixing surface 111 and the second fixing surface 112 is equal to the included angle between the sixth fixing surface 121 and the seventh fixing surface 122, and is 135 degrees; the included angle between the second fixing surface 112 and the third fixing surface 113 is equal to the included angle between the seventh fixing surface 122 and the eighth fixing surface 123, and is 135 degrees; the included angle between the third fixing surface 113 and the fourth fixing surface 114 is equal to the included angle between the eighth fixing surface 123 and the ninth fixing surface 124, and is 135 degrees; the included angle between the fourth fixing surface 114 and the fifth fixing surface 115 is equal to the included angle between the ninth fixing surface 124 and the tenth fixing surface 125, and is 135 degrees;
the first fixing surface 111, the fifth fixing surface 115, the sixth fixing surface 121 and the tenth fixing surface 125 are provided with a first bone trabecula 191;
the second fixing surface 112, the fourth fixing surface 114, the seventh fixing surface 122 and the ninth fixing surface 124 are provided with second bone trabeculae 192;
the third fixing surface 113 and the eighth fixing surface 123 are provided with a third trabecula 193;
the first trabecular bone 191 has a smaller pore size and porosity than the second 192 and third 193 trabecular bone in turn.
The aperture of the first bone trabecula 191 is 0.80mm, the porosity is 72 percent, and the through porosity is 100 percent;
the aperture of the second bone trabecula 192 is 0.93mm, the porosity is 76%, and the through porosity is 100%;
the third trabecular bone 193 has a pore diameter of 1.05mm, a porosity of 80% and a through porosity of 100%.
The first, second and third bone trabeculae 191, 192 and 193 are of equal thickness, 1.5 mm.
Preferably, the side walls 22 are provided at the edges of the fixation surfaces formed by the medial condyle fixation surface 110, the lateral condyle fixation surface 120 and the positive stop 15.
The first intermediate product, the second intermediate product, the third intermediate product and the fourth intermediate product of the cobalt alloy partition trabecular femoral condyle prosthesis have the same structures as the cobalt alloy partition trabecular femoral condyle prosthesis.
Example 2
The preparation method of the cobalt alloy zoned trabecular femoral condyle prosthesis comprises the following steps:
1) taking cobalt alloy powder as a raw material, carrying out 3D printing and integral forming to obtain a first intermediate product of the cobalt alloy partitioned trabecular bone femoral condyle prosthesis, putting the first intermediate product into a hot isostatic pressing furnace, heating to 1170 ℃ under the protection of argon, standing at 140MPa for 2h at a constant temperature, reducing to normal pressure, cooling to below 200 ℃ along with the furnace, taking out to obtain a second intermediate product:
2) placing the second intermediate product in a programmed cooling box, cooling to-100 ℃ at the speed of 1 ℃/min, placing at constant temperature for 7h, and taking out from the programmed cooling box; placing in liquid nitrogen for 24h again, and adjusting the temperature to room temperature to obtain a third intermediate product;
3) placing the third intermediate product in a programmed cooling box, cooling to-100 ℃ at the speed of 1 ℃/min, and placing for 7h at constant temperature; taking out the box from the programmed cooling box; placing in liquid nitrogen for 24h, and adjusting the temperature to room temperature; obtaining a fourth intermediate product, and performing machining trimming to obtain a cobalt alloy partitioned trabecular femoral condyle prosthesis;
the cobalt alloy powder comprises 59 mass percent of Co, 30.0 mass percent of Cr, 7.0 mass percent of Mo and the balance of inevitable trace impurities; the cobalt alloy powder had a particle size of 45 μm to 106 μm and was purchased from Acram, Sweden.
The steps 2) and 3) of adjusting the temperature are as follows: heating to-100 deg.C, and maintaining at constant temperature for 4 hr; heating to-30 deg.C, and maintaining at constant temperature for 4 hr; heating to 6 deg.C, maintaining at constant temperature for 2h, and heating.
The cobalt alloy zoned trabecular femoral condyle prosthesis has the same structure as that of example 1; the difference is that:
the included angle between the first fixing surface 111 and the second fixing surface 112 is equal to the included angle between the sixth fixing surface 121 and the seventh fixing surface 122, and is 130 degrees; the included angle between the second fixing surface 112 and the third fixing surface 113 is equal to the included angle between the seventh fixing surface 122 and the eighth fixing surface 123, and is 130 degrees; the included angle between the third fixing surface 113 and the fourth fixing surface 114 is equal to the included angle between the eighth fixing surface 123 and the ninth fixing surface 124, and is 130 degrees; the included angle between the fourth fixing surface 114 and the fifth fixing surface 115 is equal to the included angle between the ninth fixing surface 124 and the tenth fixing surface 125, and is 130 degrees;
the first fixing surface 111, the fifth fixing surface 115, the sixth fixing surface 121 and the tenth fixing surface 125 are provided with a first bone trabecula 191;
the second fixing surface 112, the fourth fixing surface 114, the seventh fixing surface 122 and the ninth fixing surface 124 are provided with second bone trabeculae 192;
the third fixing surface 113 and the eighth fixing surface 123 are provided with a third trabecula 193;
the first trabecular bone 191 has a smaller pore size and porosity than the second 192 and third 193 trabecular bone in turn.
The first bone trabecula 191 has a pore diameter of 0.74mm, a porosity of 70.0% and a through porosity of 100%;
the aperture of the second bone trabecula 192 is 0.86mm, the porosity is 74.8%, and the through porosity is 100%;
the third trabecular bone 193 has a pore diameter of 1.00mm, a porosity of 77.6% and a through-hole porosity of 100%.
The first, second and third bone trabeculae 191, 192 and 193 are of equal thickness, 0.5 mm.
The first intermediate product, the second intermediate product, the third intermediate product and the fourth intermediate product of the cobalt alloy partition trabecular femoral condyle prosthesis have the same structures as the cobalt alloy partition trabecular femoral condyle prosthesis.
Example 3
The preparation method of the cobalt alloy zoned trabecular femoral condyle prosthesis comprises the following steps:
1) taking cobalt alloy powder as a raw material, carrying out 3D printing and integral forming to obtain a first intermediate product of the cobalt alloy zoned bone trabecula femur condyle prosthesis, putting the first intermediate product into a hot isostatic pressing furnace, heating to 1200 ℃ under the protection of helium, standing at a constant temperature of 110MPa for 1h, reducing the temperature to normal pressure, cooling to below 200 ℃ along with the furnace, taking out to obtain a second intermediate product:
2) placing the second intermediate product in a programmed cooling box, cooling to-120 ℃ at the speed of 1 ℃/min, placing at constant temperature for 5h, and taking out from the programmed cooling box; placing in liquid nitrogen for 36h, and adjusting the temperature to room temperature to obtain a third intermediate product;
3) placing the third intermediate product in a programmed cooling box, cooling to-120 ℃ at the speed of 1 ℃/min, and placing for 5h at constant temperature; taking out the box from the programmed cooling box; placing in liquid nitrogen for 36h, and adjusting the temperature to room temperature; obtaining a fourth intermediate product, and performing machining trimming to obtain a cobalt alloy partitioned trabecular femoral condyle prosthesis;
the cobalt alloy powder comprises 64% of Co, 28.5% of Cr, 6% of Mo and the balance of inevitable trace impurities by mass percent; the cobalt alloy powder had a particle size of 45 μm to 106 μm and was purchased from Acram, Sweden.
The steps 2) and 3) of adjusting the temperature are as follows: heating to-80 deg.C, and maintaining at constant temperature for 3 hr; heating to-20 deg.C, and maintaining at constant temperature for 3 hr; heating to 8 deg.C, maintaining at constant temperature for 1h, and heating.
The cobalt alloy zoned trabecular femoral condyle prosthesis has the same structure as that of example 1; the difference is that:
the included angle between the first fixing surface 111 and the second fixing surface 112 is equal to the included angle between the sixth fixing surface 121 and the seventh fixing surface 122, and is 140 degrees; the included angle between the second fixing surface 112 and the third fixing surface 113 is equal to the included angle between the seventh fixing surface 122 and the eighth fixing surface 123, and is 140 degrees; the included angle between the third fixing surface 113 and the fourth fixing surface 114 is equal to the included angle between the eighth fixing surface 123 and the ninth fixing surface 124, and is 140 degrees; the included angle between the fourth fixing surface 114 and the fifth fixing surface 115 is equal to the included angle between the ninth fixing surface 124 and the tenth fixing surface 125, and is 140 degrees;
the first fixing surface 111, the fifth fixing surface 115, the sixth fixing surface 121 and the tenth fixing surface 125 are provided with a first bone trabecula 191;
the second fixing surface 112, the fourth fixing surface 114, the seventh fixing surface 122 and the ninth fixing surface 124 are provided with second bone trabeculae 192;
the third fixing surface 113 and the eighth fixing surface 123 are provided with a third trabecula 193;
the first trabecular bone 191 has a smaller pore size and porosity than the second 192 and third 193 trabecular bone in turn.
The first bone trabecula 191 has a pore diameter of 0.85mm, a porosity of 74.7% and a through porosity of 100%;
the aperture of the second bone trabecula 192 is 0.99mm, the porosity is 77.5%, and the through porosity is 100%;
the third trabecular bone 193 has a pore diameter of 1.10mm, a porosity of 85% and a through porosity of 100%.
The first 191, second 192 and third 193 bone trabeculae are 3mm thick and equal.
The first intermediate product, the second intermediate product, the third intermediate product and the fourth intermediate product of the cobalt alloy partition trabecular femoral condyle prosthesis have the same structures as the cobalt alloy partition trabecular femoral condyle prosthesis.
A rectangular first solid structure 21 can be arranged at the joint of the second fixing surface and the seventh fixing surface; the combination part of the first fixing surface and the sixth fixing surface is provided with a semicircular second solid structure 20, the thickness of the first solid structure 21 and the second solid structure 20 is equal to the thickness of the trabecula, and is 1mm, and any value in the range of 0.5mm-3mm can be selected, such as 0.5, 0.6, 0.7mm, 0.9, 1.1, 1.5, 2.0, 2.5 or 3 mm.
The first solid structure 21 and the second solid structure 20 can limit the included angle between the fourth fixing surface and the fifth fixing surface and the included angle between the ninth fixing surface and the tenth fixing surface from becoming larger in the process.
And (3) experimental verification:
finite element analysis is performed on the finite element model in the embodiment 1 of the invention, as shown in fig. 4-5, the strain cloud chart only shows the micro strain (shaded part) in the range of 1000-3000, and the percentage of the 1000-3000 micro strain area on the finite element model of the femoral condyle bone tissue in the finite element model of the whole femoral condyle bone tissue in the embodiment 1 of the invention is 65.2%, which indicates that the cobalt alloy zoned trabecular femoral condyle prosthesis realizes that the micro strain of the large part of the area is between the minimum effective strain threshold and the supraphysiological strain threshold, and has excellent bone in-growth performance.
The trabecular bone parts of control 1 and example 1 were subjected to observation analysis by scanning electron microscopy (Crossbeam340/550, zeiss, germany). As a result, as shown in fig. 6 and 7, the cobalt alloy powder in the trabecular bone structure of example 1 was further sintered as compared with the control 1, indicating that the overall performance of the trabecular bone was improved.
Metallographic microstructure observation was performed on the solid portions of control 1 and example 1. As a result, as shown in fig. 8 and 9, the precipitation σ phase was significantly reduced on the surface of example 1 as compared with control 1, indicating that the solid solubility of the alloying element in the matrix was improved and the mechanical strength was enhanced.
Tensile properties of the tensile test pieces of example 1 and comparative group 1 were tested in an electronic universal tester (UTM5105, Shenzhen Sansi technologies, Inc., China) in accordance with the standard GB/T228.1-2010, and the tensile test pieces of example 1 and comparative group 1 were 5 pieces each. As shown in Table 1, the tensile strength of example 1 was 927.35MPa, which is close to that of control 1(P > 0.05); the elongation after fracture of example 1 is 16.64%, which is higher than that of the control group 1(P < 0.01), and the cobalt alloy zoned trabecular femoral condyle prosthesis of the invention is provided with excellent plasticity of the solid part.
Table 1 tensile test results of the solid tensile test pieces of control 1 and example 1: (
n is 5, P is less than 0.01, compared with control 1)
An electronic universal tester (UTM5105, shenzhen mitsui longitudinal and transverse science and technology ltd., china) performed a compression experiment on trabecular bone compression test pieces of example 1 and control 1, each of which had a pore diameter of 0.80mm, a porosity of 72%, and a through-hole porosity of 100%, and 5 trabecular bone compression test pieces of control 1 and example 1. As shown in Table 2, the trabecular bone compressive strength of example 1 is 139.33MPa, which is significantly higher than that of control group 1, and there is a statistical difference (P < 0.05), which suggests that the compressive performance of the trabecular part of the cobalt alloy segmented trabecular femoral condyle prosthesis of the present invention is excellent.
Table 2 results of the trabecular bone test pieces compression resistance test of control 1 and example 1: (
n＝5，P < 0.05, compared with control 1)
TABLE 2
Experiments prove that the cobalt alloy partition trabecular bone femur condyle prostheses prepared in the embodiments 2 and 3 have the similar sintering degree and compression performance of cobalt alloy powder of the trabecular bone part and the similar metallographic structure and tensile performance of a solid part as those of the cobalt alloy partition trabecular bone femur condyle prostheses prepared in the embodiment 1.
Claims (8)
1. The preparation method of the cobalt alloy zoned trabecular femoral condyle prosthesis is characterized by comprising the following steps of:
1) taking cobalt alloy powder as a raw material, carrying out 3D printing and integral forming to obtain a first intermediate product of the cobalt alloy zoned bone trabecula femur condyle prosthesis, putting the first intermediate product into a hot isostatic pressing furnace, heating to 1140-1200 ℃ under the protection of helium or argon, standing for 1-3 h at a constant temperature of 110-170 MPa, reducing to normal pressure, cooling to below 200 ℃ along with the furnace, and taking out to obtain a second intermediate product:
2) placing the second intermediate product in a programmed cooling box, cooling to-80-120 ℃ at the speed of 1 ℃/min, placing at constant temperature for 5-10 h, and taking out from the programmed cooling box; placing the mixture in liquid nitrogen for 16-36 h, and adjusting the temperature to room temperature to obtain a third intermediate product;
3) placing the third intermediate product in a programmed cooling box, cooling to-80 to-120 ℃ at the speed of 1 ℃/min, and placing for 5 to 10 hours at constant temperature; taking out the box from the programmed cooling box; placing in liquid nitrogen for 16-36 h, and adjusting the temperature to room temperature; obtaining a fourth intermediate product, and performing machining and trimming to obtain a cobalt alloy partitioned trabecular femoral condyle prosthesis;
the first intermediate product, the second intermediate product, the third intermediate product and the fourth intermediate product of the cobalt alloy partition trabecular femoral condyle prosthesis have the same structures as the cobalt alloy partition trabecular femoral condyle prosthesis.
The cobalt alloy partition trabecular bone femoral condyle prosthesis comprises a medial condyle (11) and a lateral condyle (12) which are arranged on the left and right sides, wherein the anterior end (1101) of the medial condyle (11) of the medial condyle is integrated with the anterior end (1102) of the lateral condyle (12), and the posterior end of the medial condyle (11) is connected with the posterior end of the lateral condyle (12) through a limit stop (15); the lateral wall of the medial condyle (11) and the lateral wall of the lateral condyle (12) are both provided with holding grooves (16), the medial condyle (11) is provided with a medial condyle fixing surface (110), and the lateral condyle is provided with a lateral condyle fixing surface (120); the medial condyle fixing surface (110) comprises a first fixing surface (111), a second fixing surface (112), a third fixing surface (113), a fourth fixing surface (114) and a fifth fixing surface (115) which are sequentially connected, and the lateral condyle fixing surface (120) comprises a sixth fixing surface (121), a seventh fixing surface (122), an eighth fixing surface (123), a ninth fixing surface (124) and a tenth fixing surface (125) which are sequentially connected; the middle parts of the third fixing surface (113) and the eighth fixing surface (123) are provided with mounting holes (17), and the first fixing surface (111) and the second fixing surface (112) are intersected to form a first intersection line (181); the second fixing surface (112) and the third fixing surface (113) are intersected to form a second intersection line (182); the third fixing surface (113) and the fourth fixing surface (114) are intersected to form a third intersection line (183); the fourth fixing surface (114) and the fifth fixing surface (115) form a fourth intersection line (184); the intersection line of the sixth fixing surface (121) and the seventh fixing surface (122) is collinear with the first intersection line (181); the intersection line of the seventh fixing surface (122) and the eighth fixing surface (123) is collinear with the second intersection line (182); the intersection line of the eighth fixing surface (123) and the ninth fixing surface (124) is collinear with the third intersection line (183); the intersection line of the ninth fixing surface (124) and the tenth fixing surface (125) is collinear with the fourth intersection line (184); the first intersection line (181), the second intersection line (182), the third intersection line (183) and the fourth intersection line (184) are parallel to each other;
the included angle between the first fixing surface (111) and the second fixing surface (112) is equal to the included angle between the sixth fixing surface (121) and the seventh fixing surface (122), and the included angle is 130-140 degrees; the included angle between the second fixing surface (112) and the third fixing surface (113) is equal to the included angle between the seventh fixing surface (122) and the eighth fixing surface (123) and is 130-140 degrees; the included angle between the third fixing surface (113) and the fourth fixing surface (114) is equal to the included angle between the eighth fixing surface (123) and the ninth fixing surface (124), and the included angle is 130-140 degrees; the included angle between the fourth fixing surface (114) and the fifth fixing surface (115) is equal to the included angle between the ninth fixing surface (124) and the tenth fixing surface (125), and the included angle is 130-140 degrees;
the first fixing surface (111), the fifth fixing surface (115), the sixth fixing surface (121) and the tenth fixing surface (125) are provided with a first bone trabecula (191);
the second fixing surface (112), the fourth fixing surface (114), the seventh fixing surface (122) and the ninth fixing surface (124) are provided with second bone trabeculae (192);
the third fixing surface (113) and the eighth fixing surface (123) are provided with a third trabecula (193);
the first trabecular bone (191) has a smaller pore size and porosity than the second (192) and third (193) trabecular bone in that order.
2. The method as claimed in claim 1, wherein the cobalt alloy powder comprises, in mass%, 59 to 68% of Co, 26.5 to 30.0% of Cr, 4.5 to 7.0% of Mo, and the balance unavoidable trace impurities; the particle size of the cobalt alloy powder is 45-106 μm.
3. The method of claim 1, wherein the steps 2) and 3) of adjusting the temperature are: heating to-120 to-80 ℃, and keeping the temperature for 3 to 5 hours; heating to-40 to-20 ℃, and keeping the temperature for 3 to 5 hours; heating to 4-8 deg.c, maintaining for 1-3 hr, and heating.
4. The method as set forth in claim 1, wherein the first bone trabecula (191) has a pore size of 0.74mm to 0.85mm, a porosity of 70.0% to 74.7%, and a through porosity of 100%;
the aperture of the second bone trabecula (192) is 0.86mm-0.99mm, the porosity is 74.8% -77.5%, and the through porosity is 100%;
the third trabecula (193) has the aperture of 1.00-1.10 mm, the porosity of 77.6-85% and the through porosity of 100%.
5. The method of claim 1, wherein the first (191), second (192) and third (193) bone trabeculae are of equal thickness, between 0.5mm and 3 mm.
6. A method according to claim 1, characterized in that a first solid structure (21) of rectangular shape is provided at the junction of the second and seventh fixing surfaces; and a semicircular second solid structure (20) is arranged at the joint of the first fixing surface and the sixth fixing surface, and the thickness of the first solid structure (21) and the second solid structure (20) is equal to that of the trabecula and is 0.5-3 mm.
7. The method according to claim 1, characterized in that the edge of the fixation surface of the medial condyle fixation surface (110), the lateral condyle fixation surface (120) and the limit stop (15) is provided with a side wall (22).
8. A cobalt alloy zoned trabecular femoral condyle prosthesis prepared by the method of any one of claims 1 to 7.
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