CN112294258A - Salivary cortisol stress hormone collection and evaluation system - Google Patents

Salivary cortisol stress hormone collection and evaluation system Download PDF

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CN112294258A
CN112294258A CN202010492422.0A CN202010492422A CN112294258A CN 112294258 A CN112294258 A CN 112294258A CN 202010492422 A CN202010492422 A CN 202010492422A CN 112294258 A CN112294258 A CN 112294258A
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秦绍正
吴海涛
徐家华
曹红星
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Kangjian Yizhi Technology Beijing Co ltd
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Abstract

The embodiment of the specification discloses a salivary cortisol stress hormone collecting and evaluating system. The system comprises: sample collection end, sample monitoring end, sleep monitoring end, storage end, data acquisition end, sample analysis end, data processing end, wherein: the sample collection end is used for collecting a tested saliva sample; the sample monitoring end records the taking time and the putting time and sends the taking time and the putting time to the data acquisition end; the storage end stores a sample monitoring end filled with a saliva sample; the sleep monitoring end records the tested sleep time and the awakening time and sends the sleep time and the awakening time to the data acquisition end; the data acquisition end sends the taking-out time, the putting-in time, the awakening time and the sleeping time to the data processing end; the sample analysis end analyzes the concentration of the salivary cortisol in the saliva sample and sends the concentration of the salivary cortisol to the data processing end; and drawing a salivary cortisol circadian rhythm characteristic diagram by the data processing end.

Description

Salivary cortisol stress hormone collection and evaluation system
Technical Field
The specification relates to the field of psychology, and particularly relates to a salivary cortisol stress hormone collection and evaluation system.
Background
Cortisol stress hormone wake response (CAR) refers to a significant increase in cortisol secretion in the first 30-45 minutes after waking in the morning, associated with a wide range of psychological and physiological health indices, making it a key variable for psychoneuroendocrine research. The effectiveness of CAR measurements depends heavily on whether the test is strictly on a timed sampling plan, and failure to strictly adhere to timed acquisition time can introduce significant bias to the study data. However, in current studies, CAR measurements are usually made by the subject themselves at home, who subjectively records the time taken and the time of awakening, which, although easy to implement, lacks direct supervision of the researcher and may pose serious problems to CAR measurements. Moreover, the mode of recording the awakening time and the acquisition time depending on the subjective condition of the tested object is still influenced by the matching degree of the tested object, the recording accuracy and the operation accuracy, and the mode of rejecting the non-conventional sample in the subsequent analysis can bring bias to influence the scientificity of the research result. In addition, the active acquisition time recording mode increases the complexity of saliva sample acquisition, severely limits the saliva sample acquisition frequency and influences the drawing of the whole-day cortisol rhythm characteristics.
Disclosure of Invention
The embodiment of the specification provides a salivary cortisol stress hormone collection and evaluation system, which is used for overcoming at least one technical problem in the prior art.
According to a first aspect of embodiments herein, there is provided a salivary cortisol stress hormone collection assessment system comprising: sample collection end, sample monitoring end, sleep monitoring end, storage end, data acquisition end, sample analysis end, data processing end, wherein:
the sample collection end is used for collecting a tested saliva sample;
the sample monitoring end is internally provided with an accommodating space for accommodating the sample collecting end, the taking time of the sample collecting end to be taken out and the putting time of the sample collecting end filled with the saliva sample into the sample monitoring end are recorded, and the taking time and the putting time are sent to the data collecting end according to the tested number on the sample collecting end;
the storage end is used for storing a sample monitoring end filled with a saliva sample;
the sleep monitoring end is used for recording the sleep time and the wake-up time of a tested object and sending the sleep time and the wake-up time to the data acquisition end according to the tested object number on the sample acquisition end;
the data acquisition end is used for receiving the taking-out time and the putting-in time sent by the sample monitoring end, receiving the awakening time and the sleeping time sent by the sleeping monitoring end, and sending the taking-out time, the putting-in time, the awakening time and the sleeping time to the data processing end;
the sample analysis end is used for analyzing the concentration of the salivary cortisol in the saliva sample and sending the analyzed concentration of the salivary cortisol to the data processing end according to the tested number and the preset acquisition time;
and the data processing terminal is used for receiving the taking-out time, the putting-in time, the awakening time and the sleeping time sent by the data acquisition terminal, and drawing a corresponding salivary cortisol circadian rhythm characteristic diagram according to the salivary cortisol concentration in each salivary sample, the taking-out time and the putting-in time corresponding to the salivary sample, the awakening time and the sleeping time.
Optionally, the sample collection end is a test tube, and the test tube surface is pasted with a test number and the preset collection time of the saliva sample.
Optionally, the sample collection end comprises a morning collection end and a daytime collection end, the morning collection end is used for collecting the saliva sample after the test is awakened in the morning, the collection time is 6 times, and the daytime collection end is used for collecting the saliva sample in the test daytime, and the collection time is 10-12 times.
Optionally, the sample monitoring end is an electronic monitoring bottle.
Optionally, the sample monitoring end comprises a bottle cap, a pressure sensor, a timer, wherein:
the pressure sensor is used for monitoring the opening and closing of the bottle cap and sending a bottle cap opening and closing signal to the timer;
and the timer is used for receiving the bottle cap opening and closing signal, recording the time of receiving the bottle cap opening and closing signal and taking the time as the taking-out time and the putting-in time respectively.
Optionally, the temperature of the storage end ranges from-20 ℃ to-40 ℃.
Optionally, the sample monitoring end and the data acquisition end perform data transmission by a short-distance wireless communication technology.
Optionally, the sleep monitoring end and the data acquisition end perform data transmission through a serial bus.
Optionally, the data processing terminal comprises a salivary cortisol circadian rhythm profile drawing module, wherein:
the hydrocortisone circadian rhythm characteristic diagram drawing module is configured to obtain the actual acquisition time of the corresponding saliva samples according to the taking-out time and the putting-in time, judge whether the time error between the actual acquisition time and the preset acquisition time is within a preset error range, and if the time error is within the preset error range, correspond the concentration of the hydrocortisone in each saliva sample to the preset acquisition time one by one according to the preset acquisition time to obtain a time-hydrocortisone function so as to obtain the hydrocortisone circadian rhythm characteristic diagram; if the time error exceeds a preset error range and is within an error range of 15 minutes, obtaining a salivary cortisol concentration corresponding to a preset collection time according to the awakening time, the actual collection time, the preset awakening time, the time-salivary cortisol function and a preset salivary cortisol correction formula, and corresponding the salivary cortisol concentration in each saliva sample to the preset collection time in a one-to-one mode according to the preset collection time to obtain the salivary cortisol circadian rhythm characteristic diagram; if the time error exceeds the error range of 15 minutes, the saliva sample corresponding to the time error is subjected to waste treatment;
wherein the preset salivary cortisol correction formula is
Figure BDA0002521567350000041
Wherein the salivary cortisol concentration corresponding to the ith preset collection time is C (i), and the awakening time is twThe actual collection time of the ith time (0 ≦ i ≦ 7) is T (i), the salivary cortisol concentration of the saliva sample collected at the ith time is c (i), the preset collection time of the ith time is T (i), and the preset awakening time is T (i)wGenerally set TwAt point 7, the time-salivary cortisol function is f (t).
The beneficial effects of the embodiment of the specification are as follows:
according to research requirements, a researcher marks a tested serial number and preset collection time on each sample collection end, and the sample collection ends are used for reminding a tested person to collect saliva samples at the specified time. After the researcher finishes labeling the sample collection end, the sample collection end with the label is installed in the sample monitoring end. The investigator clears the records of the sample monitoring side and the sleep monitoring side. The researcher gives the sample monitoring end and the sleep monitoring end with the built-in sample collecting end to the testee and provides the testee with use instructions. After receiving the sample monitoring end and the sleep monitoring end, the tested object starts and wears the sleep monitoring end, and the sleep monitoring end records the sleep time and the awakening time of the tested object in real time. According to the use guidance, the sample collection end in the sample monitoring end is taken out, the saliva sample is collected into the sample collection end on time, the sample collection end which collects the saliva sample is arranged in the sample monitoring end, and the sample monitoring end finishes the recording of the taking-out time and the placing-in time. Thereafter, the subject places the sample monitoring end in the storage end. And after the whole acquisition task is completed, the sample monitoring end and the sleep monitoring end are handed back to the researcher. The researcher exports the data in the sample monitoring end and the sleep monitoring end through the data acquisition end, arranges the taking-out time, the putting-in time, the sleep time and the awakening time according to the tested number to obtain a complete acquisition cycle time table, and sends the acquisition cycle time table to the data processing end. The researcher sends the saliva sample to the sample analysis end, the sample analysis end analyzes the saliva sample to obtain the concentration of the salivary cortisol in the saliva sample, and the sample analysis end sends the concentration of the salivary cortisol to the data processing end according to the tested serial number and the preset collection time. And the data processing end matches the salivary cortisol concentration in each saliva sample with the corresponding time point in the collection cycle time table to obtain a salivary cortisol concentration cycle table, and a salivary cortisol circadian rhythm characteristic diagram is drawn according to the concentration cycle table. The invention automatically records the actual acquisition time of the saliva sample through the timing function of the sample monitoring end and automatically records the awakening time of the tested object through the sleep monitoring end, thus being objective and accurate. For saliva samples which cannot be collected at the preset collection time, the saliva cortisol concentration corresponding to the preset collection time can be obtained within the error range of 15min according to the arousal time, the actual collection time, the time-saliva cortisol function and the saliva cortisol correction formula, so that an accurate saliva cortisol circadian rhythm characteristic diagram can be drawn, and the problem that the recording accuracy and the operation accuracy influence the scientificity of research results caused by the mode of subjective record of arousal time and collection time in the prior art is solved. And the sample monitoring end and the sleep monitoring end are automatically recorded by electronic instruments, so that the operation is very convenient, the saliva sample number protective tool with higher frequency and more days can be collected, a more accurate salivary cortisol circadian rhythm characteristic diagram can be drawn, and the problems that the saliva sample collection complexity is increased and the saliva sample collection frequency is limited and is inaccurate in the mode of actively recording the collection time in the prior art are solved.
The innovation points of the embodiment of the specification comprise:
1. the invention automatically records the actual acquisition time of the saliva sample through the timing function of the sample monitoring end and automatically records the awakening time of the tested object through the sleep monitoring end, thus being objective and accurate. For saliva samples which cannot be collected at the preset collection time, the saliva cortisol concentration corresponding to the preset collection time can be obtained within the error range of 15min according to the arousal time, the actual collection time, the time-saliva cortisol function and the saliva cortisol correction formula, so that an accurate saliva cortisol circadian rhythm characteristic diagram can be drawn, and the problem that the recording accuracy and the operation accuracy influence the scientificity of research results caused by the mode of subjective record of arousal time and collection time in the prior art is solved. And the sample monitoring end and the sleep monitoring end are automatically recorded by electronic instruments, so that the operation is very convenient, the saliva sample number protective tool with higher frequency and more days can be collected, a more accurate salivary cortisol circadian rhythm characteristic diagram can be drawn, the problems that the collection complexity of the saliva sample is increased and the collection frequency of the saliva sample is limited and inaccurate by actively recording the collection time in the prior art are solved, and the method is one of the innovation points of the embodiment of the specification.
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In order to more clearly illustrate the embodiments of the present specification or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present specification, and other drawings can be obtained by those skilled in the art without creative efforts.
Fig. 1 is a schematic diagram illustrating an apparatus of a salivary cortisol stress hormone collection evaluation system according to an embodiment of the present disclosure;
FIG. 2a is a diagram illustrating the effect of salivary cortisol collection in a conventional collection manner provided by an embodiment of the present disclosure;
fig. 2b is a diagram illustrating the effect of salivary cortisol collection by the system provided according to an embodiment of the present disclosure;
FIG. 3 is a graph illustrating salivary cortisol circadian rhythm characteristics provided in accordance with embodiments of the present description;
FIG. 4 is a study showing the predictive memory suppression capability provided in accordance with an embodiment of the present disclosure;
FIG. 5a is a characteristic graph showing that CAR measurements provided according to embodiments herein are positively correlated with memory suppression capability;
figure 5b is a graph showing a comparison of memory suppression for high and low morning onset cortisol wake response CAR levels provided in accordance with embodiments of the present disclosure.
Detailed Description
The technical solutions in the embodiments of the present disclosure will be clearly and completely described below with reference to the drawings in the embodiments of the present disclosure, and it is obvious that the described embodiments are only a part of the embodiments of the present disclosure, and not all of the embodiments. All other embodiments obtained by a person skilled in the art based on the embodiments in the present specification without any inventive step are within the scope of the present specification.
It should be noted that the terms "including" and "having" and any variations thereof in the embodiments of the present specification and the drawings are intended to cover non-exclusive inclusions. For example, a process, method, system, article, or apparatus that comprises a list of steps or elements is not limited to only those steps or elements listed, but may alternatively include other steps or elements not listed, or inherent to such process, method, article, or apparatus.
The embodiment of the specification discloses a salivary cortisol stress hormone collecting and evaluating system. The following are detailed below.
Fig. 1 is a schematic device diagram illustrating a salivary cortisol stress hormone collection evaluation system according to an embodiment of the present disclosure. As shown in fig. 1, the collection evaluation system 100 includes: sample collection end 110, sample monitoring end 120, sleep monitoring end 130, storage end 140, data collection end 150, sample analysis end 160, data processing end 170, wherein:
the sample collection end 110 is used for collecting a tested saliva sample;
the sample monitoring end 120 is internally provided with an accommodating space for accommodating the sample collecting end, records the taking time of the sample collecting end to be taken out and the putting time of the sample collecting end filled with the saliva sample into the sample monitoring end, and sends the taking time and the putting time to the data collecting end according to the tested number on the sample collecting end;
the storage end 130 is used for storing a sample monitoring end filled with a saliva sample;
the sleep monitoring end 140 is used for recording the sleep time and the wake-up time of the testee and sending the sleep time and the wake-up time to the data acquisition end according to the test number on the sample acquisition end;
the data acquisition end 150 is configured to receive the taking-out time and the putting-in time sent by the sample monitoring end and receive the awakening time and the sleeping time sent by the sleep monitoring end, and send the taking-out time, the putting-in time, the awakening time and the sleeping time to the data processing end;
the sample analysis end 160 is used for analyzing the concentration of the salivary cortisol in the saliva sample and sending the analyzed concentration of the salivary cortisol to the data processing end according to the tested number and the preset acquisition time;
and the data processing terminal 170 is used for receiving the taking-out time, the putting-in time, the awakening time and the sleeping time sent by the data acquisition terminal, and drawing a corresponding salivary cortisol circadian rhythm characteristic diagram according to the salivary cortisol concentration in each salivary sample, the taking-out time and the putting-in time corresponding to the salivary sample, the awakening time and the sleeping time.
In one embodiment, the sample collection end 110 is a test tube, and the test tube has a test number and a preset collection time of the saliva sample attached to the surface thereof, so as to remind the test subject to collect the saliva sample at a specified time.
In one embodiment, the sample collection end 110 comprises a morning collection end for collecting saliva samples of the subject after early awakening for 6 times and a daytime collection end for collecting saliva samples of the subject during the day for 10 to 12 times. The frequent saliva sample collection during the day is scheduled, and more detailed saliva samples can be collected to map more detailed salivary cortisol circadian rhythms.
In a general embodiment, according to the research requirement, the researcher marks a test number and a preset collection time on each sample collection terminal 110, so as to remind the test to collect saliva samples at a specified time. After the investigator has completed labeling the sample acquisition end 110, the sample acquisition end 110 with the label is loaded into the sample monitoring end 120. The investigator clears the records of the sample monitoring end 120 and the sleep monitoring end 140. The researcher gives the sample monitoring terminal 120 and the sleep monitoring terminal 140 of the built-in sample collecting terminal 110 to the subject and provides the subject with instructions for use. After receiving the sample monitoring terminal 120 and the sleep monitoring terminal 140, the subject starts and wears the sleep monitoring terminal 140, and the sleep monitoring terminal 140 records the sleep time and the wake-up time of the subject in real time. According to the use instruction, the sample collection end 110 in the sample monitoring end 120 is taken out, the saliva sample is collected into the sample collection end 110 on time, the sample collection end 110 with the collected saliva sample is installed into the sample monitoring end 120, and the sample monitoring end 120 finishes the recording of the taking-out time and the placing-in time. Thereafter, the subject places the sample monitoring end 120 into the storage end 130. After the entire acquisition task is completed, the sample monitoring end 120 and the sleep monitoring end 140 are returned to the researcher. The researcher exports the data in the sample monitoring terminal 120 and the sleep monitoring terminal 140 through the data acquisition terminal 150, sorts the taking-out time, the putting-in time, the sleep time and the awakening time according to the tested number to obtain a complete acquisition cycle time table, and sends the acquisition cycle time table to the data processing terminal 170. The researcher sends the saliva sample to the sample analysis end 160, the sample analysis end 160 analyzes the saliva sample to obtain the concentration of the salivary cortisol in the saliva sample, and the sample analysis end 160 sends the concentration of the salivary cortisol to the data processing end 170 according to the tested serial number and the preset collection time. The data processing terminal 170 matches the salivary cortisol concentration in each saliva sample with the corresponding time point in the collection cycle time table to obtain a salivary cortisol concentration cycle table, and according to the concentration cycle table, a salivary cortisol circadian rhythm characteristic diagram is drawn. The invention automatically records the actual acquisition time of the saliva sample through the timing function of the sample monitoring end 120 and automatically records the awakening time of the tested object through the sleep monitoring end 140, thus being objective and accurate. For saliva samples which cannot be collected at the preset collection time, the saliva cortisol concentration corresponding to the preset collection time can be obtained within the error range of 15min according to the arousal time, the actual collection time, the time-saliva cortisol function and the saliva cortisol correction formula, so that an accurate saliva cortisol circadian rhythm characteristic diagram can be drawn, and the problem that the recording accuracy and the operation accuracy influence the scientificity of research results caused by the mode of subjective record of arousal time and collection time in the prior art is solved. And the sample monitoring end 120 and the sleep monitoring end 140 are automatically recorded by electronic instruments, so that the operation is very convenient, the saliva sample number protective tool with higher frequency and more days can be collected, a more accurate salivary cortisol circadian rhythm characteristic diagram can be drawn, and the problems that the saliva sample collection complexity is increased and the saliva sample collection frequency is limited and is inaccurate by actively recording the collection time in the prior art are solved.
Fig. 2a is a diagram illustrating a result of collecting salivary cortisol in a conventional collection manner according to an embodiment of the present disclosure, and fig. 2b is a diagram illustrating a result of collecting salivary cortisol in the system according to an embodiment of the present disclosure. As shown in fig. 2a and 2b, the conventional acquisition method may cause non-on-time sampling to occur frequently. The system adopts the timing function of the sample monitoring end 120 to record the actual acquisition time of the saliva sample, when the saliva sample is acquired each time, the pressure sensor of the sample monitoring end 120 can monitor the opening and closing of the bottle cap of the sample monitoring end 120 and send a bottle cap opening and closing signal to the timer, the timer receives the bottle cap opening and closing signal and records the time of receiving the bottle cap opening and closing signal, and the time is taken as the taking-out time or putting-in time of the sample acquisition end 110, so that the error of manual timing is avoided. The invention automatically records the actual acquisition time of the saliva sample through the timing function of the sample monitoring end 120 and the awakening time of the tested object is automatically recorded by the sleep monitoring end 140, is objective and accurate, is beneficial to drawing an accurate salivary cortisol circadian rhythm characteristic diagram, and solves the problem that the recording accuracy and the operation accuracy influence the scientificity of a research result caused by the mode of subjective record of the awakening time and the acquisition time of the tested object in the prior art.
FIG. 3 is a graph illustrating salivary cortisol circadian rhythm characteristics provided in accordance with embodiments of the present description. As shown in fig. 3, normal cortisol metabolism follows a cycle with a period of 24 hours. Typically cortisol levels are highest in the morning (about 6-8 points) and lowest in the morning (about 22-2 points). The cortisol level will drop suddenly, usually at 8-12 am, and then continue to decline slowly throughout the day until around 2 am the cortisol level begins to rise again from nadir, allowing us to wake and prepare for the day to face the new full pressure. Among them, cortisol wake response (CAR) is the most typical cortisol response pattern. Salivary Cortisol (SC) exists mainly as free cortisol in proportion to the free cortisol in blood. Salivary cortisol has the advantages of simple extraction method, easy obtaining of samples and the like, and becomes the most commonly adopted cortisol concentration detection means in scientific research.
In a particular embodiment, the salivary cortisol circadian rhythm profile may be plotted by the hydrocortisol circadian rhythm profile plotting module. Firstly, according to the taking-out time and the putting-in time, acquiring the actual collecting time of the corresponding saliva sample. Secondly, judging whether the time error between the actual acquisition time and the preset acquisition time is within a preset error range, if so, corresponding the concentration of the salivary cortisol in each saliva sample to the preset acquisition time one by one according to the preset acquisition time to obtain a time-salivary cortisol function so as to obtain the characteristic diagram of the circadian rhythm of the salivary cortisol; if the time error exceeds a preset error range and is within an error range of 15 minutes, obtaining a salivary cortisol concentration corresponding to a preset collection time according to the awakening time, the actual collection time, the preset awakening time, the time-salivary cortisol function and a preset salivary cortisol correction formula, and corresponding the salivary cortisol concentration in each saliva sample to the preset collection time in a one-to-one mode according to the preset collection time to obtain the salivary cortisol circadian rhythm characteristic diagram; if the time error exceeds the error range of 15 minutes, the saliva sample corresponding to the time error is subjected to waste treatment;
wherein the preset salivary cortisol correction formula is
Figure BDA0002521567350000111
Wherein the salivary cortisol concentration corresponding to the ith preset collection time is C (i), and the awakening time is twThe actual collection time of the ith time (0 ≦ i ≦ 7) is T (i), the salivary cortisol concentration of the saliva sample collected at the ith time is c (i), the preset collection time of the ith time is T (i), and the preset awakening time is T (i)wGenerally set TwAt point 7, the time-salivary cortisol function is f (t).
The actual collection time of the saliva sample is automatically recorded through the timing function of the sample monitoring end 120, and the awakening time of the tested object is automatically recorded through the sleep monitoring end 140, so that the test is objective and accurate. For the saliva sample which cannot be collected at the preset collection time, the saliva cortisol concentration corresponding to the preset collection time can be obtained according to the arousal time, the actual collection time, the time-saliva cortisol function and the saliva cortisol correction formula within the error range of 15min, so that the accurate saliva cortisol circadian rhythm characteristic diagram can be drawn, and the subsequent study on the memory prediction capability is facilitated.
Fig. 4 is a study process illustrating the predictive memory suppression capability provided according to an embodiment of the present description. In life, all things people want to experience are nice, however, we can also experience some negative events that occur naturally or artificially. The occurrence of negative events is often accompanied by negative memory intrusion (i.e., spontaneous memory loss), which is a key cause of many psychological disorders, including general anxiety, post-traumatic stress disorder, depression, and the like. It is worth noting that the intrusion of the negative memory can be suppressed through the active control, so that the active forgetting effect is achieved. The passive emotional experience and even psychological diseases are avoided by depending on the strength of the human body, so that the life happiness of the human body is improved. The morning onset cortisol wake response provides the basis for this self-healing ability and can be used to predict a person's memory suppression by monitoring the morning onset cortisol wake response. As shown in fig. 4, first, a plurality of subjects were recruited, and 7: 00. 7: 15. 7: 30. 8: 00. 14: 00 and 15: 00 saliva samples of the multiple subjects were obtained. In the afternoon 14: and after 00, matching the multiple tested learning faces with the negative scene, and then performing a memory suppression task. After the inhibition task is finished, a memory test is carried out on the tested object, a face is presented to the tested object, the tested object is required to recall a negative scene matched with the face, and a memory test result is obtained.
FIG. 5a is a characteristic graph showing positive correlation between CAR measurement values and memory suppression provided in an example of the present specification, and FIG. 5b is a comparison graph showing memory suppression of high and low morning cortisol wake response CAR levels provided in an example of the present specification. As shown in FIGS. 5a and 5b, the correlation analysis of the salivary cortisol concentration circadian rhythm profile and the memory test results revealed that the CAR measurement values were significantly and positively correlated with the memory inhibition process from morning. In addition, the ratio of 7: 00 to 7: the test in which the rate of increase in salivary cortisol concentration (R30) was greater than 50% between 30 was designated as the high CAR group, and the low CAR group otherwise. According to the research, higher morning onset salivary cortisol concentration can predict better memory inhibition of the tested object, and lower morning onset salivary cortisol concentration can predict poorer memory inhibition of the tested object.
Those of ordinary skill in the art will understand that: the figures are merely schematic representations of one embodiment, and the blocks or processes in the figures are not necessarily required to practice this description.
Those of ordinary skill in the art will understand that: modules in the devices in the embodiments may be distributed in the devices in the embodiments according to the description of the embodiments, or may be located in one or more devices different from the embodiments with corresponding changes. The modules of the above embodiments may be combined into one module, or further split into multiple sub-modules.
Finally, it should be noted that: the above examples are only intended to illustrate the technical solutions of the present specification, and not to limit them; although the present description has been described in detail with reference to the foregoing embodiments, it should be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the spirit and scope of the technical solutions of the embodiments of the present specification.

Claims (9)

1. A salivary cortisol stress hormone collection and evaluation system, comprising: sample collection end, sample monitoring end, sleep monitoring end, storage end, data acquisition end, sample analysis end, data processing end, wherein:
the sample collection end is used for collecting a tested saliva sample;
the sample monitoring end is internally provided with an accommodating space for accommodating the sample collecting end, the taking time of the sample collecting end to be taken out and the putting time of the sample collecting end filled with the saliva sample into the sample monitoring end are recorded, and the taking time and the putting time are sent to the data collecting end according to the tested number on the sample collecting end;
the storage end is used for storing a sample monitoring end filled with a saliva sample;
the sleep monitoring end is used for recording the sleep time and the wake-up time of a tested object and sending the sleep time and the wake-up time to the data acquisition end according to the tested object number on the sample acquisition end;
the data acquisition end is used for receiving the taking-out time and the putting-in time sent by the sample monitoring end, receiving the awakening time and the sleeping time sent by the sleeping monitoring end, and sending the taking-out time, the putting-in time, the awakening time and the sleeping time to the data processing end;
the sample analysis end is used for analyzing the concentration of the salivary cortisol in the saliva sample and sending the analyzed concentration of the salivary cortisol to the data processing end according to the tested number and the preset acquisition time;
and the data processing terminal is used for receiving the taking-out time, the putting-in time, the awakening time and the sleeping time sent by the data acquisition terminal, and drawing a corresponding salivary cortisol circadian rhythm characteristic diagram according to the salivary cortisol concentration in each salivary sample, the taking-out time and the putting-in time corresponding to the salivary sample, the awakening time and the sleeping time.
2. The system of claim 1, wherein the sample collection end is a test tube, and the test tube surface is attached with a test number and a preset collection time of the saliva sample.
3. The system according to claim 1, wherein the sample collection terminal comprises a morning collection terminal and a daytime collection terminal, the morning collection terminal is used for collecting the saliva sample after the test is awakened in the morning for 6 times, and the daytime collection terminal is used for collecting the saliva sample in the test for 10 to 12 times.
4. The system of claim 1, wherein the sample monitoring end is an electronic monitoring vial.
5. The system of claim 1, wherein the sample monitoring end comprises a bottle cap, a pressure sensor, a timer, wherein:
the pressure sensor is used for monitoring the opening and closing of the bottle cap and sending a bottle cap opening and closing signal to the timer;
and the timer is used for receiving the bottle cap opening and closing signal, recording the time of receiving the bottle cap opening and closing signal and taking the time as the taking-out time and the putting-in time respectively.
6. The system of claim 1, wherein the temperature of the storage end ranges from-20 ℃ to-40 ℃.
7. The system of claim 1, wherein the sample monitoring end and the data acquisition end perform data transmission via short-range wireless communication technology.
8. The system of claim 1, wherein the sleep monitoring terminal and the data acquisition terminal perform data transmission via a serial bus.
9. The system of claim 1, wherein the data processing side comprises a salivary cortisol circadian rhythm profile mapping module, wherein:
the hydrocortisone circadian rhythm characteristic diagram drawing module is configured to obtain the actual acquisition time of the corresponding saliva samples according to the taking-out time and the putting-in time, judge whether the time error between the actual acquisition time and the preset acquisition time is within a preset error range, and if the time error is within the preset error range, correspond the concentration of the hydrocortisone in each saliva sample to the preset acquisition time one by one according to the preset acquisition time to obtain a time-hydrocortisone function so as to obtain the hydrocortisone circadian rhythm characteristic diagram; if the time error exceeds a preset error range and is within an error range of 15 minutes, obtaining a salivary cortisol concentration corresponding to a preset collection time according to the awakening time, the actual collection time, the preset awakening time, the time-salivary cortisol function and a preset salivary cortisol correction formula, and corresponding the salivary cortisol concentration in each saliva sample to the preset collection time in a one-to-one mode according to the preset collection time to obtain the salivary cortisol circadian rhythm characteristic diagram; if the time error exceeds the error range of 15 minutes, the saliva sample corresponding to the time error is subjected to waste treatment;
wherein the preset salivary cortisol correction formula is
Figure FDA0002521567340000031
Wherein the salivary cortisol concentration corresponding to the ith preset collection time is C (i), and the awakening time is twThe actual collection time of the ith time (0 ≦ i ≦ 7) is T (i), the salivary cortisol concentration of the saliva sample collected at the ith time is c (i), the preset collection time of the ith time is T (i), and the preset awakening time is T (i)wGenerally set TwAt point 7, the time-salivary cortisol function is f (t).
CN202010492422.0A 2020-06-03 2020-06-03 Salivary cortisol stress hormone collection and evaluation system Pending CN112294258A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7233665B1 (en) 2022-09-02 2023-03-07 株式会社サリバテック Disease risk determination system and disease risk determination method

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7233665B1 (en) 2022-09-02 2023-03-07 株式会社サリバテック Disease risk determination system and disease risk determination method
JP2024035256A (en) * 2022-09-02 2024-03-14 株式会社サリバテック Disease risk determination system and disease risk determination method

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