CN112268904A - Female physiological cycle detection chip - Google Patents
Female physiological cycle detection chip Download PDFInfo
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- CN112268904A CN112268904A CN202011141481.XA CN202011141481A CN112268904A CN 112268904 A CN112268904 A CN 112268904A CN 202011141481 A CN202011141481 A CN 202011141481A CN 112268904 A CN112268904 A CN 112268904A
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- 238000001514 detection method Methods 0.000 title claims abstract description 86
- 210000003296 saliva Anatomy 0.000 claims abstract description 57
- 239000000463 material Substances 0.000 claims abstract description 11
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 4
- 239000000126 substance Substances 0.000 claims abstract description 4
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 230000001376 precipitating effect Effects 0.000 claims description 3
- 229910052710 silicon Inorganic materials 0.000 claims description 3
- 239000010703 silicon Substances 0.000 claims description 3
- 239000002244 precipitate Substances 0.000 claims 1
- 230000016087 ovulation Effects 0.000 description 35
- 238000012360 testing method Methods 0.000 description 14
- 238000002425 crystallisation Methods 0.000 description 9
- 230000008025 crystallization Effects 0.000 description 9
- 230000036760 body temperature Effects 0.000 description 8
- 230000000624 ovulatory effect Effects 0.000 description 3
- 102000009151 Luteinizing Hormone Human genes 0.000 description 2
- 108010073521 Luteinizing Hormone Proteins 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- 238000005452 bending Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 229940040129 luteinizing hormone Drugs 0.000 description 2
- 230000027758 ovulation cycle Effects 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 208000031636 Body Temperature Changes Diseases 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- WYTGDNHDOZPMIW-RCBQFDQVSA-N alstonine Natural products C1=CC2=C3C=CC=CC3=NC2=C2N1C[C@H]1[C@H](C)OC=C(C(=O)OC)[C@H]1C2 WYTGDNHDOZPMIW-RCBQFDQVSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
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- 230000029849 luteinization Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
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- 230000011599 ovarian follicle development Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000000136 postovulatory effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
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Images
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
Abstract
The invention discloses a chip for detecting a female physiological cycle. The detection chip comprises a main chip, a cover plate and a micro pump, wherein the cover plate covers the main chip; the main body chip is provided with a micro-channel and a detection pool, the micro-channel comprises a bent micro-channel and a straight micro-channel, and the flow allowed by the micro-channel at a single time can enable the detection pool to cover completely. The main chip and the cover plate are made of hydrophobic materials, and hydrophilic substances are sprayed on the detection cell to ensure that saliva can be rapidly and uniformly spread in the detection cell; when the saliva image generation device is used, saliva to be detected enters the straight micro-channel after passing through the bent micro-channel under the action of the micro-pump and finally enters the detection pool, and the saliva is rapidly expanded in the detection pool and rapidly crystallized to form the saliva image.
Description
Technical Field
The invention relates to a medical detection chip, in particular to a chip for detecting a female physiological cycle, which is used for detecting whether the female physiological cycle is in an ovulation period or a non-ovulation period.
Background
The current detection method for the female physiological cycle mainly comprises ovulation test paper detection, body temperature detection and B-ultrasonic detection; the ovulation test paper is used for detecting the peak level of the Luteinizing Hormone (LH) in urine to determine the ovulation time and the 'safe period' in the menstrual cycle of a woman, so that the aim of selecting the best opportunity for conception or using the 'safe period' for contraception is fulfilled. The detection method of the ovulation test paper needs to put the ovulation test paper in the direction of an arrow in urine for 3 seconds, then take the ovulation test paper out and put the ovulation test paper flat, observe the result in 10-20 minutes, and observe whether the ovulation test paper is strong positive (the two bars are as deep as each other or the second bar is deeper than the first bar) to determine whether the ovulation test paper is ovulation. The ovulation test paper detects the female physiological cycle, the observation result time is long, the conditions of each person are different, the sensitivity of each brand of ovulation test paper is different, or the problem of no strong positive or false strong positive can occur, so that the ovulation test paper cannot accurately detect whether the female physiological cycle is in the ovulation period or the non-ovulation period.
The body temperature detection is to determine whether the physiological cycle of a woman is in an ovulation period or a non-ovulation period by testing the basic body temperature of the human body, the basic body temperature of a woman of normal reproductive age is the same as the menstrual cycle and shows periodic change, the body temperature change is related to ovulation, the follicular phase is low, the ovulation day is lowest, and the post-ovulation temperature is increased. By measuring the basal body temperature, whether the female ovulates and the post-ovulatory luteal phase can be preliminarily known; the detection needs the body temperature measured when the body temperature is not influenced by sports diet or emotional change after the human body sleeps for 6-8 hours; the actual measurement is often influenced by muscle activity, mental stress, food, environmental temperature and the like, so that the measured basal body temperature of the human body is inaccurate, and the physiological cycle of the female can not be effectively detected;
the B-ultrasonic detection needs the examinee to go to the hospital to do B-ultrasonic, and judges whether the female physiological cycle is in the ovulation period or the non-ovulation period according to the B-ultrasonic display result, so that the examinee is inconvenient to go to the hospital to check.
The utility model discloses a chinese utility model patent is granted bulletin number CN 2673305Y, granted bulletin day 2005 1 month 26 days, and patent name "female safety phase self-test mirror", this patent is look for the medical treatment detection mirror of self physiology safety phase (non-ovulatory phase), and through this product, the woman only needs a bit of saliva to be coated on the slide, observes the saliva crystallization, both can accurately obtain whether self physiological cycle is the safety phase. The utility model discloses a saliva is even scribbled on the slide, needs natural air-dry 5-8 minutes, and the time of needs is longer, and scribble slide saliva because there is the microbubble, and the image that finally forms receives the influence of saliva bubble, and the female physiological cycle that can not accurate reflection is in ovulation phase or non-ovulation phase.
Therefore, there is a need for a new scheme for accurately and rapidly reflecting whether the physiological cycle of a woman is in an ovulatory period or a non-ovulatory period based on an image formed by the crystallization of saliva of the woman.
Disclosure of Invention
The method aims at the problem that the existing image formed according to the crystallization of the saliva of the female cannot accurately and quickly reflect whether the physiological cycle of the female is in an ovulation period or a non-ovulation period. The invention provides a chip for detecting the physiological cycle of a woman, wherein the saliva of the woman enters a detection pool through a micro-channel of the chip, the bottom plane of the detection pool is quickly and uniformly covered in the detection pool, then the image is quickly crystallized, and the condition that the physiological cycle of the woman is in an ovulation period or a non-ovulation period is quickly reflected according to the crystallized saliva image in the detection pool.
The chip for detecting the physiological cycle of the female, which is provided by the invention, is used for collecting the saliva of the female and precipitating and crystallizing the saliva and comprises a main chip and a cover plate, wherein the cover plate covers the main chip, and the upper surface of the main chip is provided with a micro-channel and a detection pool; the micro-channel is communicated with the detection pool, the detection pool is used for precipitating and crystallizing the collected saliva, and the bottom plane of the detection pool can be at least completely covered by the flow which is allowed to pass through by the micro-channel at a single time.
Preferably, the micro-channel comprises a bent micro-channel and a straight micro-channel; one end of the bent channel is arranged at the end part of the main chip, the other end of the bent channel is connected with the straight micro-channel, the bent channel comprises a plurality of bent angles, and the other end of the straight micro-channel is communicated with the detection cell.
Preferably, the main body chip and the cover plate are made of hydrophobic materials, and the detection cell is sprayed with hydrophilic substances.
Preferably, the sprayed hydrophilic material can be XZ-GT01 nano hydrophilic coating silicon, the hydrophilicity of which is: the initial hydrophilic angle is less than or equal to 10 degrees, and the continuous hydrophilic angle is less than or equal to 20 degrees.
Preferably, a transparent window is arranged at the position of the cover plate corresponding to the detection pool.
Preferably, the main body chip and the cover plate are provided with clamping grooves at two sides of the waist position, and when the chip is inserted into an external detection device, the clamping grooves enable the chip to be fixed by the corresponding buckles of the external detection device.
Preferably, the micro-pump is detachably connected to the tail of the main chip, a clamping hole is formed in the end face of the tail of the main chip, and the micro-pump is connected with the clamping hole through the clamping hole.
Preferably, the main chip is further provided with an air exhaust micro-channel arranged between the detection pool and the micro-pump.
Preferably, the end of the chip for collecting saliva is a gradual structure with a narrow top and a wide bottom.
The invention has the beneficial effects that: the invention can quickly and uniformly cover the bottom plane of the detection pool with the saliva of women, so that the saliva of the bottom plane of the detection pool is quickly precipitated and crystallized to form a saliva crystallization image, and whether the physiological cycle of women is in an ovulation period or a non-ovulation period is quickly and accurately determined according to the saliva crystallization image.
Drawings
FIG. 1 is a schematic diagram of the general structure of the present invention;
FIG. 2 is a schematic diagram of a main chip structure;
FIG. 3 is a schematic view of the location of the waist notches of the body chip and the cover plate;
FIG. 4 is a schematic view of the positions of the card holes on the end face of the tail of the main chip;
in the figure, 1: a cover plate; 2: a main body chip; 3: a micro pump; 201: a serpentine microchannel; 202: a straight microchannel; 203: a detection cell; 204: a card slot; 205: an air extraction microchannel; 206: a clamping hole;
Detailed Description
The present invention will be described in detail with reference to the specific embodiments shown in the drawings, which are not intended to limit the present invention, and structural, methodological, or functional changes made by those skilled in the art according to the specific embodiments are included in the scope of the present invention.
As shown in FIG. 1, the chip for detecting the physiological cycle of a woman of the present invention comprises a cover plate 1, a main body chip 2 and a micro pump 3;
as shown in fig. 2 and 4, the surface of the main body chip 2 is provided with a microchannel and a detection cell 203; the flow rate which the micro-channel allows at a single time can at least cover the bottom plane of the detection cell 203 completely. The microchannel includes the shape microchannel 201 of buckling and straight microchannel 202 of a plurality of angles of bending, and the shape microchannel 201 of buckling is located the tip of main part chip 2, and the shape microchannel 201 of buckling of a plurality of angles of bending is used for detaining the bubble in the saliva in the shape microchannel 201 of buckling, makes the saliva body that waits to detect form the bubble-free saliva body, prevents because the existence of bubble influences the crystallization image of saliva.
It should be noted that the bent micro-channel in the specific embodiment of the present invention is a plurality of N-shaped micro-channels, and this structure is only one of the cases in use, and all other bent micro-channels capable of retaining bubbles in saliva are within the scope of the present invention.
One end of the bent micro-channel 201 is arranged at the end of the main chip 2, the other end is connected with the straight micro-channel 202, the other end of the straight micro-channel 202 is connected with the detection cell 203, and the other end of the detection cell 203 is connected with the air-extracting micro-pipeline 205.
The main body chip 2 and the cover plate 1 are made of hydrophobic materials, and hydrophilic substances are sprayed on the detection pool 203, so that saliva can be quickly and uniformly covered with a thin layer of saliva in the detection pool 203, female saliva can be quickly precipitated and crystallized in the detection pool 203, and a saliva crystallization image is formed.
In a specific embodiment, the hydrophilic material sprayed on the detection cell 203 may be XZ-GT01 nano hydrophilic silicon coating, which has a hydrophilicity: the initial hydrophilic angle is less than or equal to 10 degrees, and the continuous hydrophilic angle is less than or equal to 20 degrees; it should be noted that the hydrophilic material in the specific embodiment of the present invention is only one of the cases in use, and any hydrophilic material that can uniformly distribute saliva in the detection cell 203 can be used as the hydrophilic material of the present invention.
The cover plate 1 covers the main chip 2, and the micro pump 3 detachably connected to the tail part of the main chip 2 is connected with the main chip 2 through the card hole 206 on the tail end face of the main chip 2, so that the bent micro channel 201, the straight micro channel 202, the detection pool 203, the air-extracting micro channel 205 and the micro pump 3 form a closed pipeline with only one open end; the open end of closed pipeline sets up the one end at bent shape microchannel 201, and is located the head end of detecting the chip, can gather saliva liquid through open end channel. When the head end of the detection chip is arranged in a solution to be detected, negative pressure is formed in a closed pipeline under the action of the micropump 3 to suck saliva, a saliva body enters the straight micro-channel 202 through the bent micro-channel 201 and finally enters the detection pool 203, the saliva body is rapidly and uniformly unfolded in the detection pool 203, a saliva image is formed after precipitation and crystallization, and a transparent window is arranged at the position, opposite to the detection pool 203, of the cover plate 2 to observe the saliva image. After the saliva image is observed, the micro pump 3 can be separated from the tail part of the main chip 2, so that the micro pump 3 can be reused, and the production cost is saved.
As shown in fig. 3, the body chip 2 and the cover plate 1 are provided with card slots 204 at two sides of the waist position, the card slots 204 are symmetrically distributed relative to the center of the chip, and a rounded corner is formed at the card slot opening of the card slot 204 and at a position close to one side of the head end of the detection chip; when the end part of the detection chip for collecting saliva is inserted into an external detection device, the clamping groove 204 enables the detection chip to be fixed by a buckle correspondingly arranged on the external detection device, so that the detection chip can be accurately inserted into a certain detection position of the detection device, and the detection chip is accurately limited; one side of the card slot of card slot 204 is rounded to facilitate insertion or removal of the test device.
As shown in fig. 2 and fig. 4, at least one card hole 206 is located at the end face of the tail end of the main chip 2, and the card hole 206 can be connected to the micro pump 3, so that the pumping micro channel 205 of the main chip 2 is communicated with the pipeline of the micro pump 3, and when the cover plate 1 completely covers the main chip 2, the detection chip forms a closed pipeline with an open head end; under the action of the micro pump 3, the closed pipeline forms negative pressure, saliva to be detected is sucked, and then the detection of the solution to be detected is completed.
As shown in fig. 1, the shape and size of the surface of the cover plate 1 are the same as those of the main chip 2, and the end of the chip for collecting saliva is a gradually changing structure with a narrow top and a wide bottom, which is convenient for holding containers of detection solutions with different sizes; meanwhile, when an external detection device is inserted, the gradual change structure with the narrow top and the wide bottom can play a role in guiding when the external detection device is just contacted with the detection device.
When in use, the cover plate 1 covers the main chip 2, and the micro pump 3 is tightly attached to the tail end face of the main chip 2 through the clamping hole 206 to form a sealed pipeline which only detects the opening of the head end of the chip; the head end part of the detection chip is inserted into an external detection device, under the action of the micro pump 3, saliva to be detected is sucked when negative pressure is formed in the micro pipeline, the saliva to be detected firstly enters the head end bent micro channel 201, bubbles in the saliva are retained in the bent micro channel 201, the saliva without bubbles continuously advances and enters the detection pool 203 through the first straight micro channel 202, the saliva to be detected enters the detection pool 203 and is rapidly and uniformly spread on the bottom plane of the whole detection pool 203 due to the fact that the detection pool 203 is sprayed with hydrophilic materials, saliva to be detected is rapidly and accurately crystallized in the detection pool 203, the crystal images of the saliva are observed through the cover plate made of transparent materials, and whether the physiological cycle of a woman is in an ovulation period or a non-ovulation period is determined.
The saliva body can be uniformly distributed on the bottom plane of the detection pool 203, the saliva body is rapidly crystallized in the detection pool 203, the formed saliva image is more accurate because no saliva bubbles interfere the crystallization image, and the female physiological cycle can be determined to be in the ovulation period or the non-ovulation period more rapidly and accurately through the detection chip.
Although the preferred embodiments of the present invention have been disclosed for illustrative purposes, those skilled in the art will appreciate that various modifications, additions and substitutions are possible, without departing from the scope and spirit of the invention as disclosed in the accompanying claims.
Claims (9)
1. A chip for detecting the physiological cycle of women, which is used for collecting the saliva of women and making the saliva precipitate and crystallize, and is characterized in that: the detection device comprises a main chip and a cover plate, wherein the cover plate covers the main chip, and the upper surface of the main chip is provided with a micro-channel and a detection pool; the micro-channel is communicated with the detection pool, the detection pool is used for precipitating and crystallizing the collected saliva, and the bottom plane of the detection pool can be at least completely covered by the flow which is allowed to pass through by the micro-channel at a single time.
2. The chip for detecting female physiological cycle as claimed in claim 1, wherein: the micro-channel comprises a bent micro-channel and a straight micro-channel; one end of the bent channel is arranged at the end part of the main chip, the other end of the bent channel is connected with the straight micro-channel, the bent channel comprises a plurality of bent angles, and the other end of the straight micro-channel is communicated with the detection cell.
3. The chip for detecting female physiological cycle as claimed in claim 1, wherein: the main chip and the cover plate are made of hydrophobic materials, and hydrophilic substances are sprayed on the detection pool.
4. The chip for detecting female physiological cycle as claimed in claim 3, wherein: the sprayed hydrophilic material can be XZ-GT01 nano hydrophilic coating silicon, the hydrophilicity of which is: the initial hydrophilic angle is less than or equal to 10 degrees, and the continuous hydrophilic angle is less than or equal to 20 degrees.
5. The chip for detecting female physiological cycle as claimed in claim 1, wherein: and a transparent window is arranged at the position of the cover plate corresponding to the detection pool.
6. The chip for detecting female physiological cycle as claimed in claim 1, wherein: the main body chip and the two sides of the waist position of the cover plate are provided with clamping grooves, and when the chip is inserted into an external detection device, the clamping grooves enable the chip to be fixed by the corresponding buckles of the external detection device.
7. The chip for detecting female physiological cycle as claimed in claim 1, wherein: still include a micropump, detachable connection is in the afterbody of main part chip, the afterbody terminal surface of main part chip is provided with the card hole, the micropump passes through card jogged joint.
8. The chip for detecting female physiological cycle as claimed in claim 7, wherein: the main chip is also provided with an air exhaust micro-channel which is arranged between the detection pool and the micro-pump.
9. The chip for detecting female physiological cycle as claimed in claim 1, wherein: the end part of the chip for collecting saliva is of a gradually-changed structure with a narrow upper part and a wide lower part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011141481.XA CN112268904A (en) | 2020-10-22 | 2020-10-22 | Female physiological cycle detection chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011141481.XA CN112268904A (en) | 2020-10-22 | 2020-10-22 | Female physiological cycle detection chip |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112268904A true CN112268904A (en) | 2021-01-26 |
Family
ID=74343045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011141481.XA Pending CN112268904A (en) | 2020-10-22 | 2020-10-22 | Female physiological cycle detection chip |
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| CN (1) | CN112268904A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102671729A (en) * | 2012-05-07 | 2012-09-19 | 博奥生物有限公司 | Micro-fluidic chip for multi-index biochemical detection |
| CN103323605A (en) * | 2013-06-18 | 2013-09-25 | 杭州普施康生物科技有限公司 | Micro-fluidic chip for glycosylated hemoglobin immunodetection |
| US20130303936A1 (en) * | 2012-05-11 | 2013-11-14 | Russell L. Case, JR. | Advanced Ovulation Predictor Device |
| CN204514801U (en) * | 2015-04-01 | 2015-07-29 | 杭州霆科生物科技有限公司 | A kind of throwing type micro-fluidic chip for residues of pesticides Site Detection |
| CN104826677A (en) * | 2015-05-05 | 2015-08-12 | 南京闻智生物科技有限公司 | Immunoassay microfluidic chip for method for examination of acute abdominal disease, and preparation method and detection method thereof |
| CN209797919U (en) * | 2018-12-11 | 2019-12-17 | 康美华大基因技术有限公司 | bacteria separation device based on micro-fluidic technology |
-
2020
- 2020-10-22 CN CN202011141481.XA patent/CN112268904A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102671729A (en) * | 2012-05-07 | 2012-09-19 | 博奥生物有限公司 | Micro-fluidic chip for multi-index biochemical detection |
| US20130303936A1 (en) * | 2012-05-11 | 2013-11-14 | Russell L. Case, JR. | Advanced Ovulation Predictor Device |
| CN103323605A (en) * | 2013-06-18 | 2013-09-25 | 杭州普施康生物科技有限公司 | Micro-fluidic chip for glycosylated hemoglobin immunodetection |
| CN204514801U (en) * | 2015-04-01 | 2015-07-29 | 杭州霆科生物科技有限公司 | A kind of throwing type micro-fluidic chip for residues of pesticides Site Detection |
| CN104826677A (en) * | 2015-05-05 | 2015-08-12 | 南京闻智生物科技有限公司 | Immunoassay microfluidic chip for method for examination of acute abdominal disease, and preparation method and detection method thereof |
| CN209797919U (en) * | 2018-12-11 | 2019-12-17 | 康美华大基因技术有限公司 | bacteria separation device based on micro-fluidic technology |
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Application publication date: 20210126 |
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