CN112244849A - Composition for electroencephalogram electrode and preparation process and application thereof - Google Patents
Composition for electroencephalogram electrode and preparation process and application thereof Download PDFInfo
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- CN112244849A CN112244849A CN202011181979.9A CN202011181979A CN112244849A CN 112244849 A CN112244849 A CN 112244849A CN 202011181979 A CN202011181979 A CN 202011181979A CN 112244849 A CN112244849 A CN 112244849A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
- A61B2562/125—Manufacturing methods specially adapted for producing sensors for in-vivo measurements characterised by the manufacture of electrodes
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Abstract
The invention provides a composition for an electroencephalogram electrode, a preparation process and application thereof, wherein the composition comprises, by mass, 0.5-10% of carrageenan, 12-40% of a water-retaining agent, 0.5-10% of a conductive salt, 0.5-5% of other additives and the balance of deionized water. The electroencephalogram flexible elastic gel electrode prepared by the method is superior to a dry electrode in electrical performance, is obviously more convenient and simpler to use than a wet electrode, has the characteristics of low impedance and high signal-to-noise ratio in a word, is environment-friendly and sanitary, is comfortable to wear, and can be used for electroencephalogram collection quickly and without residues.
Description
Technical Field
The invention belongs to the technical field of artificial intelligence, and particularly relates to a composition for an electroencephalogram electrode, and a preparation process and application thereof.
Background
Electroencephalography (EEG) is used primarily for the diagnosis of intracranial organic lesions in humans, such as: examination of epilepsy, encephalitis, cerebrovascular diseases, intracranial space occupying lesions and the like. With the development of science and technology, the application of electroencephalogram signals is more extensive, such as brain-computer interface (BCI).
In recent years, the application of brain-computer interfaces is being widely focused at home and abroad, and various bioelectricity-based wearable products such as electroencephalogram are being developed. With the development of electronic technology and signal processing technology, an electrode sensing device for conveniently and effectively measuring electroencephalogram signals has become a major challenge in the field. The existing electroencephalogram recording mainly adopts a wet electrode and a dry electrode. The wet electrode is formed by smearing conductive paste between the electrode and the skin, the conductive paste permeates into hairs, the electroencephalogram is connected to the electrode through ionic current, and accurate and reliable electroencephalogram signals can be obtained. However, it is inconvenient because of long preparation time, and it is necessary to wash the hair because the conductive paste remains on the scalp after use. The existing dry electrode mainly adopts a rigid metal pillar or a flexible conductive silica gel claw type or a flexible polymer brush-shaped design, can be directly contacted with the scalp, does not need conductive paste matching and auxiliary wearing of a professional assistant, is contacted with an electrode-skin interface only by an electronic conductor, has poor interface characteristics, and has acupuncture feeling after being worn for a long time.
At present, gel electrodes are mostly applied to the aspects of electrocardio, myoelectricity, physiotherapy and the like, but there is a fresh report on flexible elastic gel electrodes for collecting electroencephalogram in a hairy area.
Disclosure of Invention
The invention aims to provide a composition for an electroencephalogram electrode, which aims at the hair areas of the scalp, is soft, has high compression strength, good rebound resilience, stable performance and good biocompatibility, and a preparation process and application thereof.
In order to realize the aim, the invention provides a composition for an electroencephalogram electrode, which comprises the following components in percentage by mass,
0.5 to 10 percent of carrageenan;
12 to 40 percent of water-retaining agent;
0.5 to 10 percent of conductive salt;
0.5 to 5 percent of other auxiliary agents;
the balance being deionized water.
As a further improvement of the invention, the water-retaining agent comprises one or two of glycerol and 1, 2-propylene glycol.
As a further improvement of the invention, the conductive salt comprises one or both of potassium chloride or sodium chloride.
As a further improvement of the invention, the other auxiliary agents comprise one or more of preservative, essence and pigment, wherein the preservative comprises cason.
The invention also provides a preparation process of the composition for the electroencephalogram electrode, which comprises the following steps,
a. weighing the raw materials according to the proportion, then adding the water-retaining agent into the carrageenan, and fully stirring and uniformly mixing to obtain a mixture A;
b. adding conductive salt and other additives into deionized water, heating to 70-80 deg.C, stirring for dissolving for 5-15min to obtain mixture B;
c. adding the mixture A into the mixture B, heating to 80-100 ℃, and stirring and mixing uniformly for 30-60min to obtain the brain electrode composition.
The invention also provides application of the composition for the electroencephalogram electrode in preparation of an electroencephalogram gel electrode.
As a further improvement of the invention, the application process on the preparation comprises the following steps,
transferring the composition for the electroencephalogram electrode into electrode packaging equipment, performing perfusion molding, cooling and sealing to obtain the flexible elastic gel electrode for acquiring the electroencephalogram in the hair area of the scalp.
Compared with the prior art, the invention has the following beneficial effects:
the electroencephalogram electrode which is convenient, comfortable and good in signal quality is a bottleneck for limiting electroencephalogram application, and the gel electrode is an electrode integrating the advantages of dry and wet electrodes. The gel electrode is used for replacing the conductive paste, the electroencephalogram can be rapidly acquired without residue, and the wearing is comfortable. The brain gel electrode prepared by the invention uses the water-based polymer gel which is soft, high in compression strength, good in rebound resilience, stable in performance and good in biocompatibility, has the characteristics of low impedance and high signal-to-noise ratio, is environment-friendly and sanitary, is comfortable to wear, and can be used for quickly and residue-free electroencephalogram collection.
Drawings
FIG. 1 is a graph showing the correlation coefficient between signals of a gel electrode and a wet electrode of a conductive paste according to an embodiment;
FIG. 2 is another graph showing the correlation between signals of a gel electrode and a wet electrode of a conductive paste according to an embodiment;
Detailed Description
The present invention will be described in detail below with reference to embodiments shown in the drawings. The embodiments are not intended to limit the present invention, and structural, methodological, or functional changes made by those skilled in the art according to the embodiments are included in the scope of the present invention.
The signal acquisition is an important factor for restricting the brain-computer interface from moving from a laboratory to real life application, for a noninvasive brain-computer interface based on scalp electroencephalogram, a brain-computer interface system of a wet electrode scheme needs to spend a long time preparing conductive paste, and hair needs to be cleaned after use, while a previous dry electrode system mainly acquires electroencephalogram signals of a forehead area, the decoded brain state is few, the accuracy rate is low, and the actual use scene is limited.
Based on the above situation, the present embodiment provides a composition for an electroencephalogram electrode, which comprises the following components by mass percent,
0.5 to 10 percent of carrageenan;
12 to 40 percent of water-retaining agent;
0.5 to 10 percent of conductive salt;
0.5 to 5 percent of other auxiliary agents;
the balance being deionized water.
The water-retaining agent comprises one or two of glycerin and 1, 2-propylene glycol, the conductive salt comprises one or two of potassium chloride or sodium chloride, the other auxiliary agents comprise one or more of a preservative, essence and a pigment, and the preservative comprises kasong.
The invention also provides a preparation process of the composition for the electroencephalogram electrode, which comprises the following steps,
a. weighing the raw materials according to the proportion, then adding the water-retaining agent into the carrageenan, and fully stirring and uniformly mixing to obtain a mixture A;
b. adding conductive salt and other additives into deionized water, heating to 70-80 deg.C, stirring for dissolving for 5-15min to obtain mixture B;
c. adding the mixture A into the mixture B, heating to 80-100 ℃, and stirring and mixing uniformly for 30-60min to obtain the brain electrode composition.
Specifically, the application process of the composition for an electroencephalogram electrode in preparation of an electroencephalogram gel electrode in the embodiment includes transferring the composition for an electroencephalogram electrode into electrode packaging equipment, performing perfusion molding, then cooling and sealing, and obtaining the flexible elastic gel electrode for electroencephalogram in a scalp hair area. In the actual packaging process, the electrodes can be packaged into electrodes with different shapes according to the use requirements, so that different use scenes are met.
In order to better embody the technical effects of the present invention, the following embodiments and test results are further described.
Example 1
a. Weighing 2g of carrageenan, adding 24g of glycerol, and fully stirring and uniformly mixing to obtain a mixture A;
b. weighing 2g of sodium chloride and 0.3g of kasong, adding the sodium chloride and the 0.3g of kasong into 71.7g of deionized water, heating, stirring and dissolving to obtain a mixture B;
c. adding the mixture A into the mixture B, heating, stirring and uniformly mixing to obtain the composition for the electroencephalogram electrode;
d. transferring the composition for the electroencephalogram electrode into a subpackaging device, performing perfusion forming, cooling and sealing to obtain the medical electroencephalogram gel electrode.
Preferably, the heating temperature in the step 2 is 70-80 ℃, and the time is 5-15 min;
preferably, the heating temperature in the step 3 is 80-100 ℃ and the time is 30-60 min.
Example 2
a. Weighing 1g of carrageenan, adding 30g of glycerol, and fully stirring and uniformly mixing to obtain a mixture A;
b. weighing 1g of sodium chloride and 0.1g of cason, adding into 67.9g of deionized water, heating, stirring and dissolving to obtain a mixture;
c. adding the mixture A into the mixture B, heating, stirring and uniformly mixing to obtain the composition for the electroencephalogram electrode;
d. transferring the composition for the electroencephalogram electrode into a subpackaging device, performing perfusion forming, cooling and sealing to obtain the medical electroencephalogram gel electrode.
Preferably, the heating temperature in the step 2 is 70-80 ℃, and the time is 5-15 min;
preferably, the heating temperature in the step 3 is 80-100 ℃ and the time is 30-60 min.
Example 3
a. Weighing 4g of carrageenan, adding 12g of glycerol, and fully stirring and uniformly mixing to obtain a mixture A;
b. weighing 3g of sodium chloride and 0.5g of cason, adding into 81.5g of deionized water, heating, stirring and dissolving to obtain a mixture;
c. adding the mixture A into the mixture B, heating, stirring and uniformly mixing to obtain the composition for the electroencephalogram electrode;
d. transferring the composition for the electroencephalogram electrode into a subpackaging device, performing perfusion forming, cooling and sealing to obtain the medical electroencephalogram gel electrode.
Preferably, the heating temperature in the step 2 is 70-80 ℃, and the time is 5-15 min;
preferably, the heating temperature in the step 3 is 80-100 ℃ and the time is 30-60 min.
Example 4
a. Weighing 2.2g of carrageenan, adding 36g of glycerol, and fully stirring and uniformly mixing to obtain a mixture A;
b. weighing 2.1g of sodium chloride and 0.5g of cason, adding into 59.2g of deionized water, heating, stirring and dissolving to obtain a mixture;
c. adding the mixture A into the mixture B, heating, stirring and uniformly mixing to obtain the composition for the electroencephalogram electrode;
d. transferring the composition for the electroencephalogram electrode into a subpackaging device, performing perfusion forming, cooling and sealing to obtain the medical electroencephalogram gel electrode.
Preferably, the heating temperature in the step 2 is 70-80 ℃, and the time is 5-15 min;
preferably, the heating temperature in the step 3 is 80-100 ℃ and the time is 30-60 min.
The results of the measurement of the correlation coefficient between the gel electrode of the above examples 1-4 and the wet electrode signal of the conductive paste are shown in fig. 1 and fig. 2, and it can be seen that the gel electrode prepared by the present invention is significantly higher than the dry electrode in the correlation coefficient between the wet electrode signal of the conductive paste and is close to 100%, while in the prior art, the correlation coefficient between the dry electrode and the wet electrode signal of the conductive paste is only about 85%, and it can be seen that the gel electrode prepared by the present invention can basically achieve the use effect of the wet electrode in the use performance, but is significantly more convenient than the wet electrode in the use process.
The electroencephalogram gel electrode prepared by the method is obviously superior to a dry electrode in electrical performance, is obviously more convenient and simpler to use than a wet electrode, has the characteristics of low impedance and high signal-to-noise ratio in a word, is environment-friendly and sanitary, is comfortable to wear, and can be used for electroencephalogram collection quickly and without residues.
It should be understood that although the terms first, second, third, etc. may be used in one or more embodiments of the present description to describe various information, such information should not be limited to these terms. These terms are only used to distinguish one type of information from another. For example, first information may also be referred to as second information, and similarly, second information may also be referred to as first information, without departing from the scope of one or more embodiments herein. The word "if" as used herein may be interpreted as "at … …" or "when … …" or "in response to a determination", depending on the context.
The above description is only for the purpose of illustrating the preferred embodiments of the one or more embodiments of the present disclosure, and is not intended to limit the scope of the one or more embodiments of the present disclosure, and any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the one or more embodiments of the present disclosure should be included in the scope of the one or more embodiments of the present disclosure.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (7)
1. A composition for an electroencephalogram electrode, which is characterized in that: comprises the following components in percentage by mass,
0.5 to 10 percent of carrageenan;
12 to 40 percent of water-retaining agent;
0.5 to 10 percent of conductive salt;
0.5 to 5 percent of other auxiliary agents;
the balance being deionized water.
2. The composition for electroencephalogram electrodes according to claim 1, characterized in that: the water-retaining agent comprises one or two of glycerol and 1, 2-propylene glycol.
3. The composition for electroencephalogram electrodes according to claim 1, characterized in that: the conductive salt comprises one or two of potassium chloride or sodium chloride.
4. The composition for electroencephalogram electrodes according to claim 1, characterized in that: the other auxiliary agents comprise one or more of preservative, essence and pigment, wherein the preservative comprises Kathon.
5. A process for preparing a composition for brain electrical electrodes according to claim 1, characterized in that: comprises the following steps of (a) carrying out,
a. weighing the raw materials according to the proportion, then adding the water-retaining agent into the carrageenan, and fully stirring and uniformly mixing to obtain a mixture A;
b. adding conductive salt and other additives into deionized water, heating to 70-80 deg.C, stirring for dissolving for 5-15min to obtain mixture B;
c. adding the mixture A into the mixture B, heating to 80-100 ℃, stirring and mixing uniformly for 30-60min to obtain the brain electrode composition.
6. An application of a composition for an electroencephalogram electrode in preparation of an electroencephalogram gel electrode.
7. The application of the composition for the electroencephalogram electrode in the preparation of the electroencephalogram gel electrode according to claim 6, and is characterized in that: the application process of the preparation comprises the following steps,
transferring the composition for the electroencephalogram electrode into electrode packaging equipment, performing perfusion molding, cooling and sealing to obtain the flexible elastic gel electrode for acquiring the electroencephalogram in the hair area of the scalp.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550795A (en) * | 2013-10-24 | 2014-02-05 | 苏州格林泰克科技有限公司 | Electrode abrading and conducting adhesive and preparation method thereof |
| CN109620977A (en) * | 2018-11-21 | 2019-04-16 | 索思（苏州）医疗科技有限公司 | A kind of medical conducting resinl and its preparation process and application |
| CN109715058A (en) * | 2016-09-30 | 2019-05-03 | 波尔图大学 | The clean polymer solution for forming injection aquagel of scalp is monitored and is easy to for reliable EEG |
| CN110655663A (en) * | 2019-10-29 | 2020-01-07 | 索思（苏州）医疗科技有限公司 | Medical conductive gel and preparation method thereof |
| CN110746617A (en) * | 2019-10-29 | 2020-02-04 | 索思（苏州）医疗科技有限公司 | Medical conductive gel and preparation method thereof |
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- 2020-10-29 CN CN202011181979.9A patent/CN112244849A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550795A (en) * | 2013-10-24 | 2014-02-05 | 苏州格林泰克科技有限公司 | Electrode abrading and conducting adhesive and preparation method thereof |
| CN109715058A (en) * | 2016-09-30 | 2019-05-03 | 波尔图大学 | The clean polymer solution for forming injection aquagel of scalp is monitored and is easy to for reliable EEG |
| CN109620977A (en) * | 2018-11-21 | 2019-04-16 | 索思（苏州）医疗科技有限公司 | A kind of medical conducting resinl and its preparation process and application |
| CN110655663A (en) * | 2019-10-29 | 2020-01-07 | 索思（苏州）医疗科技有限公司 | Medical conductive gel and preparation method thereof |
| CN110746617A (en) * | 2019-10-29 | 2020-02-04 | 索思（苏州）医疗科技有限公司 | Medical conductive gel and preparation method thereof |
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Application publication date: 20210122 |