CN112237684A - Artificial cochlea electrode and manufacturing method thereof - Google Patents
Artificial cochlea electrode and manufacturing method thereof Download PDFInfo
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- CN112237684A CN112237684A CN201910649034.6A CN201910649034A CN112237684A CN 112237684 A CN112237684 A CN 112237684A CN 201910649034 A CN201910649034 A CN 201910649034A CN 112237684 A CN112237684 A CN 112237684A
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- electrode
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
- A61N1/0541—Cochlear electrodes
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D1/00—Coating compositions, e.g. paints, varnishes or lacquers, based on inorganic substances
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01R—ELECTRICALLY-CONDUCTIVE CONNECTIONS; STRUCTURAL ASSOCIATIONS OF A PLURALITY OF MUTUALLY-INSULATED ELECTRICAL CONNECTING ELEMENTS; COUPLING DEVICES; CURRENT COLLECTORS
- H01R13/00—Details of coupling devices of the kinds covered by groups H01R12/70 or H01R24/00 - H01R33/00
- H01R13/02—Contact members
- H01R13/03—Contact members characterised by the material, e.g. plating, or coating materials
Abstract
The invention discloses a cochlear implant electrode and a manufacturing method thereof, the cochlear implant electrode comprises a plurality of single electrodes and coating layers thereof, the single electrodes comprise electrode wires, insulating coatings, a substrate and graphene coatings, wherein the electrode wires are made of conductive metal and comprise a base part and a lead part thereof, the insulating coatings are made of insulating materials and coat the lead part, the substrate is made of insulating materials and is arranged in the base part, the graphene coatings are attached to the substrate and the base part, and the coating layers are made of insulating materials with biological safety and coat the single electrodes but expose the graphene coatings. According to the cochlear implant electrode and the manufacturing method thereof, the graphene coating made of graphene is used as the contact, so that higher charge storage capacity can be obtained, the contact impedance with cochlear tissues is reduced, the fibrosis of the cochlear tissues on the surface of the contact is prevented, the working stability is improved, and the service life is prolonged.
Description
Technical Field
The invention relates to a cochlear implant electrode and a manufacturing method thereof.
Background
The artificial cochlea includes two parts of external device and internal implanted device, the signal transmission between the external device and the internal implanted device is completed by electromagnetic induction, and the two parts are separated by skin, and have no wire connection, the external device includes microphone, speech processor and its transmitter, and the internal implanted device includes receiver and its electrode, and the sound is received by microphone, converted into electric signal, then transferred into speech processor to amplify and filter the signal, and transferred into receiver by transmitter, and the produced electric pulse is transferred into contact of electrode, so that the ganglion cell in the cochlea can be stimulated, the auditory nerve can be excited, and the sound information can be transferred into brain to produce auditory sense.
In the whole cochlear implant system, the intracorporeal implant device is the most critical part, the extracorporeal device can only realize the recovery of hearing through the intracorporeal implant device, and the electrode is the most important part of the intracorporeal implant device. The contact materials of the electrodes in the current market are all made of noble metals, and are conventionally made of platinum or platinum-iridium alloy. The material has good biological safety and chemical stability, and the contacts are all smooth surfaces in the prior art so as to avoid damage to cochlear tissues in the implantation process, but the platinum or platinum-iridium alloy contacts with smooth surfaces have weak charge storage capacity, so that the electrical stimulation effect of the cochlear implant is limited. In order to improve the charge loading capacity of the electrode contact, the surface of the contact is subjected to micro-modification by laser, and the loading capacity is improved by electroplating a noble metal material on the surface of the platinum contact and increasing the loading area. In addition, a contact made of platinum materials is implanted for a long time, and the surface cochlear tissue of part of patients is fibrillated, so that the electric pulse stimulation effect and the postoperative rehabilitation effect are influenced.
Disclosure of Invention
In view of the above-mentioned defects in the prior art, the technical problem to be solved by the present invention is to provide a cochlear implant electrode and a method for manufacturing the same, which uses graphene as a contact.
To achieve the above objects, the present invention provides a cochlear implant electrode comprising a plurality of single electrodes and a coating layer thereof, the single electrodes comprising a wire electrode, an insulating coating, a substrate, and a graphene coating, wherein the wire electrode is made of a conductive metal and comprises a base portion and a wire portion thereof, the insulating coating is made of an insulating material and covers the wire portion, the substrate is made of an insulating material and is disposed in the base portion, the graphene coating is attached to the substrate and the base portion, and the coating layer is made of an insulating and biologically safe material and covers the single electrodes but exposes the graphene coating.
The single electrode also comprises an enzyme type bioelectrode layer, wherein the enzyme type bioelectrode layer is positioned between the substrate and the graphene coating, the enzyme type bioelectrode layer is made of an enzyme type bioelectrode material, and the enzyme type bioelectrode material is formed by mixing an acetic acid solution dissolved with chitosan and a multi-walled carbon nano tube.
The graphene coating layer only exposes the middle part, and the rest part is still covered by the coating layer.
The coating layer, the substrate and the insulating coating are all made of silica gel.
The base portion is annular in shape.
The invention provides a manufacturing method of a cochlear implant electrode, which comprises the following steps: (A) bending one end of a wire electrode into a base with a certain shape, wherein the bent part is called a base part, the rest part is called a wire guide part, coating a substrate material on the base part, removing the substrate material on one surface of the base part, the surface is called a front surface, only the substrate material in the middle of the front surface of the base part is left to form a substrate, coating an enzyme type bioelectrode material on the front surface of the substrate to form an enzyme type bioelectrode layer, and manufacturing a single electrode semi-finished product, wherein the base part is in a circular ring shape, the wire guide part is coated with an insulating coating, the insulating coating and the substrate are both made of insulating materials, and the wire electrode is made of conductive metal; (B) placing the single-electrode semi-finished product into plasma treatment equipment, and carrying out plasma treatment on the front surface of the base part and the enzyme type bioelectrode layer; (C) placing the single-electrode semi-finished product after plasma treatment into graphene electrolyte, connecting a circuit on the wire part, and depositing a graphene coating on the front surface of the base part and the enzyme type bioelectrode layer to prepare a single-electrode finished product; (D) rinsing the single electrode finished product by deionized water, and then drying at low temperature; (E) and packaging the single electrode finished products into electrode finished products by using a coating layer, wherein the graphene coating is in an exposed state.
The graphene coating layer only exposes the middle part, and the rest part is still covered by the coating layer.
The coating layer, the substrate and the insulating coating are all made of silica gel.
The interval between step B and step C is less than 60 minutes.
In the step D, the deionized rinsing is carried out for at least five times, the low-temperature drying temperature is 20-30 ℃, and the humidity is 30-50% RH.
The artificial cochlea electrode and the manufacturing method thereof of the invention use the graphene coating made of graphene as the contact, can obtain higher charge storage capacity, reduce the contact impedance with the cochlea tissue, prevent the fibrosis of the cochlea tissue on the surface of the contact, improve the working stability and prolong the service life.
The conception and the technical effects of the present invention will be further described below to fully understand the objects, features and effects of the present invention.
Drawings
Fig. 1 is a schematic partial cross-sectional view of a cochlear implant electrode of the present invention.
Fig. 2 is a schematic partial cross-sectional view of a wire electrode and an insulating coating.
Fig. 3 is a schematic view of a wire electrode and a substrate.
Fig. 4 is a schematic view of a wire electrode and a graphene coating.
Fig. 5 is a flow chart of the manufacturing method of the cochlear implant electrode of the present invention.
Fig. 6 is a schematic diagram of three forms of cochlear implant electrodes of the present invention.
Detailed Description
The invention is further elucidated below.
As shown in fig. 1, the present invention provides a cochlear implant electrode comprising a plurality of single electrodes 1 and their coating layers 2, as shown in fig. 2 to 4, the single electrodes 1 comprise a wire electrode 11, an insulating coating 12, a substrate 13, and a graphene coating 14, wherein the wire electrode 11 is made of a conductive metal and comprises a base portion 111 and a wire portion 112 thereof, i.e., a portion of the wire electrode 11 constitutes a shaped base, preferably a circular ring, for production and processing, for mounting the substrate 13, and the remaining portion constitutes a wire for conduction of electrical pulses, the insulating coating 12 is made of an insulating material, such as silica gel, which coats the wire portion 112 and prevents electrical leakage of the wire portion 112, the substrate 13 is made of an insulating material, such as silica gel, which is disposed in the base portion 111, the substrate 13 plays a supporting role, the graphene coating 14 is attached to the substrate 13 and the base portion 111, the graphene coating 14 is attached to the substrate 13 at the middle portion and attached to the base portion 111 at the periphery portion, and the coating layer 2 is made of an insulating and bio-safe material, such as silicon gel, which covers the single electrode 1 but exposes the graphene coating 14. It should be reminded that the graphene coating 14 need not be exposed completely, but only the middle portion may be exposed, and the rest portion is still covered by the coating layer 2, so that the graphene coating 14 can be effectively prevented from being detached.
The single electrode 1 further comprises an enzyme type bioelectrode layer, wherein the enzyme type bioelectrode layer is positioned between the substrate 13 and the graphene coating 14, namely, the graphene coating 14 is indirectly attached to the substrate 13 through the enzyme type bioelectrode layer, the enzyme type bioelectrode layer is made of an enzyme type bioelectrode material, and the enzyme type bioelectrode material is formed by mixing an acetic acid solution dissolved with chitosan and a multi-walled carbon nanotube.
Compared to conventional noble metal contacts, the graphene coating 14 has the following advantages: 1. since graphene has excellent charge storage capacity, the graphene coating 14 not only can obtain higher charge storage capacity, but also can reduce contact impedance with cochlear tissues; 2. since graphene is a good neural interface material, the graphene coating 14 can prevent fibrosis of cochlear tissue on the contact surface. 3. Since graphene has excellent thermal stability and chemical stability, is resistant to strong acid and strong alkali, and has excellent stability, the graphene coating 14 can stably work in a human body for a long time.
When the cochlear implant electrode works, electric pulses are transmitted to the base part 111 through the lead part 112, and then ganglion cells in the cochlea are stimulated through the graphene coating 14, so that auditory nerves are excited, sound information is transmitted to the brain, and auditory sense is generated.
As shown in fig. 5, the invention also provides a manufacturing method of the cochlear implant electrode, which comprises five steps of shaping and curing, plasma treatment, electrochemical deposition, rinsing and packaging, and specifically comprises the following steps:
1. shaping and curing: one end of the wire electrode 11 is bent into a base with a certain shape, the bent part is called a base part 111, the rest part is called a wire part 112, the base part 111 is coated with a substrate material, the substrate material on one surface of the base part 111, the surface is called a front surface, only the substrate material in the middle of the front surface of the base part 111 is left to form a substrate 13, the front surface of the substrate 13 is coated with an enzyme type bioelectrode material to form an enzyme type bioelectrode layer to facilitate the subsequent graphene attachment to manufacture a single electrode 1 semi-finished product, wherein, the base part 111 is in a ring shape, the wire part 112 is coated with an insulating coating 12, the wire electrode 11 can be coated with the insulating coating 12 first and then bent to form the base part 111, but before bending, the insulating coating 12 at the bent part is removed, at this time, although the step of removing the insulating coating 12 is added, but the manufacturing process is simple, the wire electrode 11 can be bent to form the base part 111, and then the wire part 112 is coated with the insulating coating 12, at this time, although the steps are reduced, the difficulty of the manufacturing process is increased;
2. plasma treatment: placing the single electrode 1 semi-finished product into plasma treatment equipment, and carrying out plasma treatment on the front surface of the base part 111 and the enzyme type bioelectrode layer so as to improve the bonding strength of subsequent graphene with the base part 111 and the enzyme type bioelectrode layer;
3. electrochemical deposition: placing the semi-finished product of the single electrode 1 after plasma treatment into graphene electrolyte, connecting a circuit by the wire part 112 to perform electrochemical deposition, and depositing the graphene coating 14 on the front surface of the base part 111 and the enzyme type bioelectrode layer through multiple cycles to prepare a finished product of the single electrode 1, namely, the graphene coating 14 is attached to the enzyme type bioelectrode layer and the front surface of the base part 111;
4. rinsing: rinsing the single electrode 1 finished product by deionized water, and then drying at low temperature, wherein the deionized rinsing is carried out for at least five times, the temperature of low-temperature drying is 20-30 ℃, and the humidity is 30-50% RH;
5. packaging: and packaging a plurality of single electrode 1 finished products into electrode finished products by using a coating layer 2, wherein the graphene coatings 14 are arranged at equal intervals and are exposed, preferably, the graphene coatings 14 are in a semi-exposed state, namely, only the middle part is exposed, as shown in fig. 6, and the electrode finished products can be in a straight electrode form a, a slightly bent electrode form B or a pre-bent electrode form C.
The interval between the plasma treatment step and the electrochemical deposition step is less than 60 minutes, so that better process effect is achieved.
The foregoing detailed description of the preferred embodiments of the invention has been presented. It should be understood that numerous modifications and variations could be devised by those skilled in the art in light of the present teachings without departing from the inventive concepts. Therefore, the technical solutions available to those skilled in the art through logic analysis, reasoning and limited experiments based on the prior art according to the concept of the present invention should be within the scope of protection defined by the claims.
Claims (10)
1. A cochlear implant electrode characterized by: the single electrode comprises a wire electrode, an insulating coating, a substrate and a graphene coating, wherein the wire electrode is made of conductive metal and comprises a base part and a lead part thereof, the insulating coating is made of insulating material and covers the lead part, the substrate is made of insulating material and is arranged in the base part, the graphene coating is attached to the substrate and the base part, and the coating is made of insulating and biologically safe material and covers the single electrode but exposes the graphene coating.
2. The cochlear electrode of claim 1, wherein: the single electrode also comprises an enzyme type bioelectrode layer, wherein the enzyme type bioelectrode layer is positioned between the substrate and the graphene coating, the enzyme type bioelectrode layer is made of an enzyme type bioelectrode material, and the enzyme type bioelectrode material is formed by mixing an acetic acid solution dissolved with chitosan and a multi-walled carbon nano tube.
3. The cochlear electrode of claim 1, wherein: the graphene coating layer only exposes the middle part, and the rest part is still covered by the coating layer.
4. The cochlear electrode of claim 1, wherein: the coating layer, the substrate and the insulating coating are all made of silica gel.
5. The cochlear electrode of claim 1, wherein: the base portion is annular in shape.
6. A manufacturing method of a cochlear implant electrode comprises the following steps: (A) bending one end of a wire electrode into a base with a certain shape, wherein the bent part is called a base part, the rest part is called a wire guide part, coating a substrate material on the base part, removing the substrate material on one surface of the base part, the surface is called a front surface, only the substrate material in the middle of the front surface of the base part is left to form a substrate, coating an enzyme type bioelectrode material on the front surface of the substrate to form an enzyme type bioelectrode layer, and manufacturing a single electrode semi-finished product, wherein the base part is in a circular ring shape, the wire guide part is coated with an insulating coating, the insulating coating and the substrate are both made of insulating materials, and the wire electrode is made of conductive metal; (B) placing the single-electrode semi-finished product into plasma treatment equipment, and carrying out plasma treatment on the front surface of the base part and the enzyme type bioelectrode layer; (C) placing the single-electrode semi-finished product after plasma treatment into graphene electrolyte, connecting a circuit on the wire part, and depositing a graphene coating on the front surface of the base part and the enzyme type bioelectrode layer to prepare a single-electrode finished product; (D) rinsing the single electrode finished product by deionized water, and then drying at low temperature; (E) and packaging the single electrode finished products into electrode finished products by using a coating layer, wherein the graphene coating is in an exposed state.
7. The method of manufacturing of claim 6, wherein: the graphene coating layer only exposes the middle part, and the rest part is still covered by the coating layer.
8. The method of manufacturing of claim 6, wherein: the coating layer, the substrate and the insulating coating are all made of silica gel.
9. The method of manufacturing of claim 6, wherein: the interval between step B and step C is less than 60 minutes.
10. The method of manufacturing of claim 6, wherein: in the step D, the deionized rinsing is carried out for at least five times, the low-temperature drying temperature is 20-30 ℃, and the humidity is 30-50% RH.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201910649034.6A CN112237684A (en) | 2019-07-18 | 2019-07-18 | Artificial cochlea electrode and manufacturing method thereof |
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| CN201910649034.6A CN112237684A (en) | 2019-07-18 | 2019-07-18 | Artificial cochlea electrode and manufacturing method thereof |
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| CN112237684A true CN112237684A (en) | 2021-01-19 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114404675A (en) * | 2022-01-28 | 2022-04-29 | 上海派拉纶生物技术股份有限公司 | Biocompatible coating for insulation protection of medical needle |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114404675A (en) * | 2022-01-28 | 2022-04-29 | 上海派拉纶生物技术股份有限公司 | Biocompatible coating for insulation protection of medical needle |
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