CN112233759A - Coronary heart disease management cloud platform system and intelligent medicine box - Google Patents

Coronary heart disease management cloud platform system and intelligent medicine box Download PDF

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Publication number
CN112233759A
CN112233759A CN202011100694.8A CN202011100694A CN112233759A CN 112233759 A CN112233759 A CN 112233759A CN 202011100694 A CN202011100694 A CN 202011100694A CN 112233759 A CN112233759 A CN 112233759A
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medicine
module
password
medicine box
patient
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刘明
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Beijing Fu Yun Cloud Data Technology Co ltd
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Beijing Fu Yun Cloud Data Technology Co ltd
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
    • A61J7/0427—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers with direct interaction with a dispensing or delivery system
    • A61J7/0436—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers with direct interaction with a dispensing or delivery system resulting from removing a drug from, or opening, a container
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
    • A61J7/0454—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers for dispensing of multiple drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
    • A61J7/0481—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers working on a schedule basis
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F21/00—Security arrangements for protecting computers, components thereof, programs or data against unauthorised activity
    • G06F21/30—Authentication, i.e. establishing the identity or authorisation of security principals
    • G06F21/31—User authentication
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F21/00—Security arrangements for protecting computers, components thereof, programs or data against unauthorised activity
    • G06F21/30—Authentication, i.e. establishing the identity or authorisation of security principals
    • G06F21/44—Program or device authentication
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G16H40/67—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H80/00—ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
    • H04L63/00—Network architectures or network communication protocols for network security
    • H04L63/08—Network architectures or network communication protocols for network security for authentication of entities
    • H04L63/083—Network architectures or network communication protocols for network security for authentication of entities using passwords

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  • Health & Medical Sciences (AREA)
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  • Business, Economics & Management (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Business, Economics & Management (AREA)
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  • Medical Treatment And Welfare Office Work (AREA)

Abstract

Provided are a cloud platform system and an intelligent medicine box. The system cloud platform system comprises a sanitation management department terminal, a patient terminal and an intelligent medicine box which are connected through a network, and application programs are all configured on the sanitation management department terminal and the intelligent medicine box; an application program configured on the patient terminal controls the audio unit to control the display unit to display the medicine taking dosage and the medicines according to the medicine taking schedule; the application program configured by the intelligent medicine box controls the sound device to sound and the light-emitting device to emit light according to the medicine taking schedule, and the application program configured by the intelligent medicine box further comprises a password authentication module which determines whether to open the medicine box cover according to the password card identification result of a patient or a caregiver. The cloud platform system and the intelligent medicine box have high automation degree and good safety.

Description

Coronary heart disease management cloud platform system and intelligent medicine box
Technical Field
The invention relates to a coronary heart disease management cloud platform system and an intelligent medicine box, and belongs to the technical field of internet medical treatment.
Background
Through investigation, the prevalence rate of coronary heart disease in China is 1.59% in cities, 0.48% in rural areas and 0.77% in total, and the prevalence rate is on the rise. Coronary heart disease ranks the first cause of death in the united states and many developed countries. However, since the 60's of the 20 th century in the united states, there has been a downward trend in coronary heart disease mortality. Due to efforts in the 60-80 s to reduce risk factors for coronary heart disease, efforts have been made primarily to control risk factors and improve treatment of myocardial infarction. In 2009, the death rate of coronary heart disease is 94.96/10 ten thousand for Chinese city residents, 71.27/10 ten thousand for rural areas, the city is higher than the rural areas, and the male is higher than the female.
Whether patients with coronary heart disease can take medicine regularly or not is the key to successful treatment. The current situation and main problems are as follows: manual dispensing has poor automation and low safety.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention aims to provide a cloud platform system and an intelligent medicine box, which are high in automation degree and safety.
In order to achieve the purpose, the invention provides a cloud platform system which comprises a sanitation management department terminal, a patient terminal and an intelligent medicine box which are connected through a network, wherein the sanitation management department terminal, the patient terminal and the intelligent medicine box are all configured with application programs; an application program configured on the patient terminal controls the audio unit to pronounce according to the medicine taking schedule, and controls the display unit to display the medicine taking dosage and the medicines; the application program configured by the intelligent medicine box controls the sound device to sound and the light-emitting device to emit light according to the medicine taking schedule, and the application program configured by the intelligent medicine box further comprises a password authentication module which determines whether to open the medicine box cover according to the password card identification result of a patient or a caregiver.
Preferably, the working process of the password authentication module comprises the following steps:
step 1: connecting a port of the password card with a connector of the intelligent medicine box, receiving a medicine taking code input by a user by the password card, comparing the medicine taking code with a prestored medicine taking code, sending a comparison result into a password module A, if the comparison is unsuccessful, giving an alarm by the password card and stopping working, and if the comparison is successful, performing the step 2;
step 2: the password module A of the password card and the embedded control processor of the intelligent medicine box carry out bidirectional password authentication; a password module A of the password card prestores a password KA, a password module B of the intelligent medicine box prestores a password KB, the password KA and the password KB have the same value, and the password module A and the password module B preset the same HMAC algorithm; the password module A and an embedded processor of the intelligent medicine box carry out two-way password authentication, and the whole authentication process is considered to be successful only when the two-way authentication is successful; if the authentication is unsuccessful, the password card stops working, and if the authentication is successful, the step 3 is carried out;
and 3, step 3: calculating the abstract value of the embedded operating system image stored in the intelligent medicine box main memory by the embedded processor of the password card, comparing the abstract value with the original abstract value of the embedded operating system image stored in the password module B of the intelligent medicine box, if the comparison is unsuccessful, alarming and stopping working by the password card, and if the comparison is successful, carrying out the step 4;
and 4, step 4: the box cover is opened to intelligence medicine box.
Preferably, the process of the bidirectional password authentication between the cryptographic module a and the embedded processor of the intelligent medicine box is as follows:
step 2-1: the cryptographic module A generates a random number RAAnd use a pre-stored password KAPerforming HMAC operation, and storing the operation result y1A＝HMAC(RA||KA) Wherein R isA||KARepresents the random number RAAnd a password KAThe cipher module A sends random number R to the embedded processor of the intelligent medicine boxA；
Step 2-2: intelligenceThe embedded processor of the medicine box uses the prestored password KBAnd received RAPerforming HMAC operation to obtain the result y1B＝HMAC(RA||KB) Wherein R isA||KBRepresents the random number RAAnd a password KBData connected together, the embedded processor of the intelligent medicine box sends y1 to the cryptographic module AB；
Step 2-3: cipher module A of intelligent medicine box for received y1BAnd the saved operation result y1AComparing, if the two are the same, the verification is successful, the password module A sends the information of 'authentication passing' to the embedded processor of the intelligent medicine box, and the 2 nd step to the 4 th step are carried out; otherwise, the password module A sends authentication failure information to the embedded processor of the intelligent medicine box;
step 2-4: embedded processor of intelligent medicine box generates random number RBAnd use a pre-stored password KBPerforming HMAC operation, and storing the operation result y2B＝HMAC(RB||KB) Wherein R isB||KBRepresents the random number RBAnd a password KBThe data connected together, the embedded processor of the intelligent medicine box sends the random number R to the cipher module AB；
Step 2-5: the cipher module A uses the pre-stored password KAAnd received RBPerforming HMAC operation to obtain the result y2A＝HMAC(RB||KA) Wherein R isB||KARepresents the random number RBAnd a password KAData connected together, the cryptographic module A sends y2 to the embedded processor of the intelligent medicine boxA；
And 2, step 6: embedded processor of intelligent medicine box pair received y2AAnd the saved operation result y2BAnd comparing, if the two are the same, successfully verifying, and sending the 'authentication passing' information to the password module A by the embedded processor of the intelligent medicine box, otherwise, sending the 'authentication failure' information to the password module A by the embedded processor of the intelligent medicine box.
Preferably, the medicine distribution equipment comprises a plurality of medicine distribution devices, each medicine distribution device comprises a medicine distribution mechanism and a controller, the control system is connected with the terminal for the pharmacy, the distribution mechanism comprises a rotating shaft, a fixed shaft, a guide shaft and a belt pressing shaft which are arranged in parallel, two medicine packaging clamping frames are movably arranged on the rotating shaft, the fixed shaft, the guide shaft and the belt pressing shaft, each clamping frame is provided with a first through hole, a second through hole, a third through hole and a sliding groove along a first direction, a groove is arranged along a second direction, and the first direction is vertical to the second direction; the rotating shaft, the fixed shaft, the guide shaft and the belt pressing shaft are respectively inserted into the first through hole, the second through hole, the third through hole and the sliding groove, the rotating shaft and the fixed shaft are respectively provided with a driving wheel and a driven wheel at the positions of the grooves, the driving wheel is fixed on the rotating shaft, the driven wheel is movably sleeved on the fixed shaft, and the driving wheel and the driven wheel are provided with a transmission belt; the transmission belt is provided with bulges at equal intervals, and the diameter of the through hole of the medicine package is the same as that of the bulges; the guide shaft is inserted into the third through hole, and a support wheel is arranged at the position of the groove; the pressing shaft is inserted into the sliding groove, the pressing wheel is arranged at the position of the groove of the pressing shaft, and the pressing shaft moves in the sliding groove so that the pressing wheel presses the medicine package on the supporting wheel, or a certain gap is kept between the pressing wheel and the supporting wheel, so that the medicine package passes through the gap; the medicine distribution mechanism further comprises a driving mechanism and a belt pressing mechanism, the driving mechanism comprises a first motor and a first transmission mechanism, and the first motor drives the rotating shaft to rotate through the first transmission mechanism, so that the conveying belt carries medicine packages to operate; the belt pressing mechanism comprises a second motor and a second transmission mechanism, and the second motor drives the belt pressing shaft to move in the sliding groove through a second rotating machine, so that the medicine package passes through or does not pass through.
Preferably, each drug dispensing mechanism dispenses a drug, the control system further comprising a plurality of sensors, each sensor for reading drug information of a drug package dispensed by a drug root mechanism; the control system also comprises a metering module, a comparison module and a control module, wherein the metering module is used for metering and distributing the medicine amount distributed by the distribution mechanism according to the information provided by the sensor; the comparison module is used for comparing the dispensed medicine quantity with the medicine quantity recorded in the prescription, and when the dispensed medicine quantity is smaller than the medicine quantity recorded in the prescription, the control module controls the dispensing mechanism to continuously dispense the medicine until the dispensed medicine quantity reaches the medicine quantity recorded in the prescription.
Preferably, the health management department terminal comprises at least a physician terminal and a pharmacy terminal, the physician terminal is configured with an application program, and the application program comprises a patient treatment scheme making module, a medicine taking plan making module, a patient follow-up plan making module and a re-diagnosis plan making module, wherein the patient treatment scheme making module and the medicine taking plan making module are configured to record patient symptoms, issue a detection sheet, determine patient symptoms according to detection data, and issue a treatment scheme and a prescription according to the patient symptoms; the follow-up patient planning module is configured to determine a follow-up plan according to patient symptoms; the re-diagnosis plan making module determines a re-diagnosis plan according to the symptoms of the patient; the application program configured by the terminal for the pharmacy receives the prescription of the doctor and controls the medicine distribution equipment to distribute the medicines to the electronic intelligent medicine boxes according to the prescription.
Preferably, the terminal for the patient is configured with an application program which comprises a patient module at least comprising a medicine taking module and a backlog module, wherein the medicine taking module is configured to be capable of viewing a medicine taking plan, modifying or viewing a medicine taking time, reminding the patient to take medicine when the medicine taking time is reached, and requesting the patient to upload a medicine taking effect according to a prompt; the backlog module is configured to view the follow-up plan, select whether to accept follow-up visits and follow-up forms according to the prompt.
Preferably for the management of patients with coronary heart disease
In order to achieve the purpose, the invention further provides an intelligent medicine box in the cloud platform system, which comprises a processor, a light-emitting device, an embedded processor, a sound device, a medicine box cover driving mechanism, a communication subsystem and a memory, wherein an application program is stored in the memory, the processor calls the application program to implement the function of a medicine taking module in the intelligent medicine box, the medicine taking module is configured to control the sound device to sound according to a medicine taking schedule, control the light-emitting device to emit light, provide a control signal for the embedded processor of the medicine box to enable the embedded processor of the medicine box to carry out oral authentication on a password card of a user, and send the control signal to a box cover control circuit to drive a cover control mechanism to open a box cover after the password card is authenticated, so that the user takes out.
Compared with the prior art, the cloud platform system and the intelligent medicine box provided by the invention have the advantages of high automation degree and good safety.
Drawings
FIG. 1 is a schematic diagram of a cloud platform system provided by the present invention;
FIG. 2 is a schematic view of a pharmaceutical package provided by the present invention;
FIG. 3 is a schematic view of the internal structure of a medication dispensing apparatus provided by the present invention;
FIG. 4 is a schematic assembled component view of a medication package holding bracket according to the present invention;
FIG. 5 is a schematic view of an exploded view of a medication package holding bracket according to the present invention;
FIG. 6 is a circuit diagram of a control system of a medication dispensing apparatus provided by the present invention;
FIG. 7 is a block diagram of the control system of the intelligent medicine box provided by the present invention;
FIG. 8 is a block diagram of the components of the present invention that provide a password card;
fig. 9 is an input/output circuit diagram provided by the present invention.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it should be understood that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In describing the present invention, it is to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. The use of the terms "comprises" and/or "comprising," and the like, are intended to specify the presence of stated features, integers, and/or components, but do not preclude the presence or addition of one or more other features, integers, components, and/or groups thereof. The term "and/or" includes any and all combinations of one or more of the associated listed items. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
In addition, the technical features involved in the different embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
Fig. 1 is a schematic diagram illustrating a cloud platform system according to the present invention, and as shown in fig. 1, the cloud platform system according to the present invention includes a terminal for a health administration department, a terminal for a patient, a server, and an intelligent medicine box, which are linked via a network, the server is configured with a cloud database, and a doctor uses an application program configured by the terminal for the health administration department to make a treatment plan, a follow-up plan, and a follow-up plan for a coronary disease patient, and distributes a medicine for treating a coronary heart disease into the intelligent medicine box through a medicine distribution device; the intelligent medicine box comprises a password authentication module and a password card identification module, wherein the password card identification module is used for determining whether to open a medicine box cover according to the result of the password card identification of a patient or a caregiver.
The health management department terminal at least comprises a terminal for a physician and a terminal for a pharmacy, wherein the terminal for the physician is provided with an application program, and the application program comprises a patient treatment scheme making module, a medicine taking plan making module, a patient follow-up plan making module and a re-diagnosis plan making module, wherein the patient treatment scheme making module and the medicine taking plan making module are configured to record patient symptoms, issue a detection sheet, determine patient symptoms according to detection data and issue a treatment scheme and a prescription according to the patient symptoms; the follow-up patient planning module is configured to determine a follow-up plan according to patient symptoms; the re-diagnosis plan making module determines a re-diagnosis plan according to the symptoms of the patient; and the application program configured by the terminal for the pharmacy receives the prescription of the doctor and controls the medicine distribution equipment to distribute the medicine for treating the coronary heart disease to the electronic intelligent medicine box according to the prescription.
In the invention, the terminal for the patient is configured with an application program which comprises a patient module at least comprising a medicine taking module and a backlog module, wherein the medicine taking module is configured to be capable of checking a medicine taking plan, modifying or checking the medicine taking time, reminding the patient to take medicine when the medicine taking time is reached, and requesting the patient to upload a medicine taking effect according to a prompt; the backlog module is configured to view the follow-up plan, select whether to accept follow-up visits and follow-up forms according to the prompt.
In the present invention, in order to facilitate spraying of the medicine taking time on the medicine package according to the prescription of the doctor, the medicine for treating coronary heart disease is packaged by the package shown in fig. 2.
Fig. 2 is a schematic view of a medicine package provided by the present invention, as shown in fig. 2, the package 100 is used for packaging medicines, and has a rectangular design, positioning holes 101 are equally spaced on two parallel sides, the positioning holes 101 are used for driving the package 100 to operate so as to dispense medicines by an intelligent prescription vending cabinet, and the packages 100 adjacent to each other are connected along a perforation seam 102 to form a string. The package 100 is preferably a single sealed bag joined to each other at a perforated seam 102. The package 100 is preferably painted with the dosing time when one side of the package is marked, coded or otherwise identified to indicate their respective information and the other side of the package is used to dispense the medication. Preferably, all information, such as a name of a medicine, a price, a functional indication, ingredients, properties, specifications, a usage, manufacturing company information, a production date, an expiration date, etc., is encoded using the bar code 102. It should be appreciated that the information described above may be marked with optically readable text in addition to the bar code 102. Preferably, the package 100 may also include information in the form of instructions to facilitate operation of the drug dispensing device. Preferably, the package 100 includes at least a paper layer onto which the dosing time is sprayed and a permeation prevention layer disposed within the paper layer. More preferably, the month, day and hour characters of the administration time are printed on the paper layer of the package in advance, and the figures of the administration time are sprayed by the spraying device, so that the medicine can be dispensed at an accelerated speed without spending much time due to the spraying service time.
Fig. 3 is a schematic diagram of an internal structure of a medicine dispensing device in the cloud platform system, which provides medicines to an intelligent medicine box according to a doctor's prescription. The drug dispensing device allows for monitoring and controlling the dispensing of the drug such that a pharmacist can directly access the drug dispensing device to dispense the drug to the smart cartridge according to the prescription.
The intelligent drug dispensing device has a body with a housing comprising a left side wall, a right side wall, a front panel 11, a rear panel 12, a top panel 13 and a bottom panel 14 defining an internal cavity, the front panel 11 having a door or access panel arranged for pivotal movement about a set of hinges to enable a pharmacist to access the interior of the internal cavity. The interior cavity is divided by partitions into M rows and N columns of rectangular parallelepiped spaces in a direction perpendicular to the base plate 14, each space being provided with a drug dispensing device comprising a housing comprising a left side wall, a right side wall, a front panel 15, a rear panel 16, a top panel 17 and a base plate 18 defining an interior cavity, the left or right side wall of each drug dispensing device having a door or access panel arranged for pivotal movement about a set of hinges to enable access to the interior of the drug dispensing device by authorised personnel. It will be appreciated that the housing and the partition of the medication dispensing apparatus and device may be constructed of any suitable material, such as a plastic or metal material, and further that the housing may be manufactured using any suitable construction method, such as injection molding, stamping, machining, and the like. Desirably, the back panel 12 of the device has an opening through which the power module 26 may be disposed. In the present invention, the medicine dispensing device is formed in a rectangular parallelepiped shape, and the medicine dispensing device is inserted into each rectangular parallelepiped space after the medicine to be dispensed is placed in the medicine dispensing device. The drug dispensing device is connected to the interface on the partition by an interface to provide power and control data to the drug dispensing device.
The housing may be constructed as a single piece of material or otherwise constructed from two or more pieces of material that are connected to one another. The front panel 11 of the device also has an opening 19 through which the pharmacist removes the smart cartridge 25 with the medicine dispensed, the opening 19 being opened or closed by a door. .
As shown in fig. 3, the medication dispensing apparatus is sized to accommodate a medication dispensing mechanism and a plurality of medication packages 100, the packages 100 being wound on spools 22.
Referring again to fig. 3, the drug dispensing apparatus further includes a control system in operative communication with each of the plurality of drug dispensing devices to regulate the plurality of drug dispensing devices to dispense the drug according to the doctor's prescription and deliver the drug to the smart cartridge. The plurality of dispensing devices are identical in composition and each comprise a drug dispensing mechanism 30 disposed within an internal chamber of the dispensing device, each drug dispensing mechanism 30 dispensing a drug to a drug output port 23, the drug having a drug package 100 as shown in figure 2. Each dispensing mechanism 30 is driven by a drive mechanism comprising a motor M2 (not shown in fig. 3) and a drug delivery mechanism 32, the motor M2 having a shaft with a drive member, such as a drive gear having a predetermined number of radially outwardly extending teeth. The motor M2 drives the rotary shaft 33 to rotate via the drug delivery mechanism 32, thereby causing the conveyor belt 42 to run the drug-loaded package 100.
As shown in fig. 3, the drug dispensing device has a chamber 24 for capturing the drug packages 100. The chamber 24 is defined by the front panel 11 of the medication dispensing apparatus, the front panels 15 of the plurality of medication dispensing devices and the left and right side walls of the medication dispensing apparatus.
As shown in fig. 3, the medicine dispensing mechanism 30 includes a rotating shaft 33 and a fixed shaft 34 which are arranged in parallel, the rotating shaft 33 and the fixed shaft 34 are movably provided with two medicine package holders 200, the two medicine package holders 200 are used for holding two sides of the medicine package 100, so that the medicine located in the middle is not damaged, and the information on the upper side of the medicine package is readable, and the medicine taking time can be sprayed from the lower side.
FIG. 4 is a schematic assembled component view of a medication package holding bracket according to the present invention; fig. 5 is an exploded view of the medication package holding bracket provided by the present invention. As shown in fig. 4 to 5, each holder 200 is provided with a first through-hole 201 and a second through-hole 202 in a first direction (axial direction of the rotary shaft 33), and a groove 203 in a second direction (axial direction perpendicular to the rotary shaft), the first direction and the second direction being perpendicular; the rotating shaft 33 is disposed in the first through hole 201 through a bearing, which can rotate in the bearing; the fixed shaft 34 is inserted into the second through hole 202, the rotating shaft 33 and the fixed shaft 34 are respectively provided with a driving wheel 35 and a driven wheel 36 at the position of the groove 203, the driving wheel 35 is fixed on the rotating shaft 33 through a mounting pad 220, the rotating shaft 33 rotates, and the driving wheels rotate in the same speed and the same direction. The driven wheel 36 is movably fitted on the fixed shaft 34 via a rotation wheel 221, the driven wheel 36 is fixedly connected with the rotation wheel 221, and the driven wheel 36 and the rotation wheel 221 rotate around the fixed shaft 34. The driving pulley 35 and the driven pulley 36 are connected by a transmission belt 42. Preferably, the driving belt 42 is provided with protrusions 43 at equal intervals, the diameter of the positioning holes of the medicine packages is the same as that of the protrusions 43, and the pitch of the positioning holes of the medicine packages 100 is the same as that of the protrusions.
According to an embodiment of the present invention, the holding frames 200 are further provided with locking devices 204, and after the medicine packages 100 are fixed on the two holding frames 200, the locking devices 204 fix the holding frames 200 on the fixing shaft 34.
According to an embodiment of the present invention, the clamping frame 200 is further provided with a third through hole 205 and a sliding slot 206, the dispensing mechanism further comprises a guide shaft 37 and a pinch shaft 39 which are arranged in parallel, the guide shaft 37 is inserted into the third through hole 205, a support wheel 38 is arranged at the position of the groove 203, the support wheel 38 is arranged on the guide shaft 37 through a mounting pad 219, and the guide shaft is fixed on the clamping frame; the tape pressing shaft 39 is inserted into the sliding groove 206, the tape pressing shaft 39 is provided with the tape pressing wheel 40 at the position of the groove 203, the tape pressing wheel 40 is arranged on the tape pressing shaft 37 through a mounting pad 218, and the tape pressing mechanism can drive the tape pressing shaft to move in the sliding groove 206 so that the tape pressing wheel 40 presses the medicine package on the supporting wheel 38 or a certain gap is kept between the tape pressing wheel 40 and the supporting wheel 38, so that the medicine package 100 passes through the gap.
Preferably, the distance between the fixed shaft 34 and the rotating shaft 33 is a first distance which is less than or equal to the length of one medicine package in the conveying direction of the conveyor belt 42, and the distance between the rotating shaft 33 and the guide shaft 37 is a second distance which is less than the first distance.
Preferably, the holder 200 includes a first plate 207 and a second plate 209 axially disposed along the fixed shaft 34 and extending in a direction perpendicular to the fixed shaft 34, with a groove 203 formed between the first plate 207 and the second plate 209. The first plate 207 is provided with a third plate 208 arranged perpendicularly thereto, the third plate extending in a direction perpendicular to the fixed shaft 34; the second plate 209 is provided with a fourth plate 210 arranged perpendicularly thereto, the fourth plate 210 extending in a direction perpendicular to the fixed shaft 34; rectangular notches 212 and 213 are respectively arranged on two opposite sides of the third plate 208 and the fourth plate 210, when the third plate 208 and the fourth plate 210 are spliced together, the two rectangular notches form a first through hole 214, and the protrusions 43 on the transmission belt 42 extend out of the through holes 214. The fourth plate 210 has an "L" shape, and a fifth plate 211 extending in a third direction (perpendicular to the first direction and the second direction) is disposed at one end of the fourth plate 211, and a sliding groove 206 is disposed on the fifth plate 211.
According to the present invention, the holder 200 further includes a tape pressing plate 215, the tape pressing plate 215 is provided with a second through hole 216 corresponding to the first through hole 214 along the second direction, the tape pressing plate 215 and the fourth plate 210 are connected by a rotating mechanism 217, the tape pressing plate 215 holds the medicine package when in the open position, and the tape pressing plate 215, the third plate 208 and the fourth plate 210 clamp the edge of the medicine package 100 when in the closed position.
According to the present invention, the medicine dispensing mechanism further comprises a tape pressing mechanism including a motor M1 and a transmission mechanism 58, wherein the motor M1 drives the tape pressing shaft 39 to move on the chute 206 through the rotation mechanism 58, so that the tape pressing wheel 40 presses the medicine package 100 against the supporting wheel 38, or a gap is maintained between the tape pressing wheel 40 and the supporting wheel, so that the medicine package 100 passes through the gap. The motor M1 has a shaft with a drive member, such as represented by a drive gear having a predetermined number of radially outwardly extending teeth. One end of the tape pressing shaft 39 is provided with a rotating wheel having a predetermined number of teeth extending radially outward, the rotating wheel being directly engaged with the driving member.
According to one embodiment of the invention, the drug dispenser mechanism 30 further comprises a spray device disposed above or below the dispensing mechanism and interposed between the two belts 42 of the two gripper blocks 200. Preferably, the dispensing mechanism 30 further includes a fixing shaft (not shown), and the holder is further provided with a fifth through hole (not shown) in the first direction, and the fixing shaft is inserted into the fifth through hole; the spraying equipment at least comprises a spray head and a spray head driving mechanism, the spray head driving mechanism drives the spray head to move along the axial direction of the fixed shaft, and the control system controls the spraying equipment to spray the medicine taking time on the medicine package 100 while driving the distribution mechanism 30 to distribute the medicine package.
When the medicine package is installed, the pressing plates 215 of the two clamping frames are lifted, the first package of the string of medicine packages 100 passes through a gap formed between the pressing shaft 39 and the guide shaft 37 between the two package clamping frames 200, through holes on two sides of the package 100 are arranged on the bulges 43 on the conveying belts 42 of the two clamping frames 200, then the pressing plates 215 are put down, so that the clamping frames are fixed on the fixed shaft 34 through the locking devices 204, the medicine package string is fixed, and the medicine is dispensed by waiting for the command of the control system.
In the present invention, a sensor 41 is provided above the dispensing mechanism for reading information on the pharmaceutical product package 100, from which information the dose dispensed by the dispensing mechanism 30 can be metered.
Fig. 6 is a circuit diagram of a control system of a drug dispensing device according to the present invention, which comprises a controller 51, such as a CPU, as shown in fig. 6. The control system also includes an input output interface 52 for connection to a pharmacy control terminal. The control system also includes a touch screen display 53 for displaying information and for user input such as prescription, drug name, price, indications of function, ingredients, properties, specifications, usage, manufacturing enterprise information, date of manufacture, expiration date, etc. The control system also includes a communication subsystem 54 for wirelessly connecting with the pharmacy terminal. The control system further comprises a near field matching circuit 55 for linking the drug dispensing with the pharmacist's handheld terminal via a near field protocol. The control system further has a memory 50 for storing application programs and data, the CPU calls the programs to form a dispensing module configured to control the drug dispensing mechanism to dispense drugs to the smart cartridges according to the prescription; a spray module configured to spray a dosing time on the pharmaceutical packaging during dispensing of the pharmaceutical.
More specifically, as shown in fig. 6, the control system further includes a medicine dispensing mechanism controller including a motor driver 64, a motor driver 65 and a sensor 41, the processor control module sends signals to the motor driver 64 and the motor driver 65, calculates the medicine taking dose and the medicine taking time of each medicine according to the prescription, the CPU sends a control signal to the motor driver 65, so that the motor M1 drives the belt pressing mechanism 58 to operate, the belt pressing mechanism 58 drives the belt pressing shaft 39 to operate in the chute 206 to drive the belt pressing wheel 40 to move away from the support wheel 38, and a gap is formed between the belt pressing wheel 40 and the support wheel 38; meanwhile, the motor driver 64 sends a driving signal to the motor M2, the motor M2 drives the medicine conveying mechanism 32 to rotate, so that the driving wheel 35 rotates together, the conveying belt 42 drives the driven wheel 36 to rotate and drives the medicine packages 100 to operate, when the carried medicine packages operate to a proper position, the medicine conveying mechanism stops rotating, the spraying module enables the spraying mechanism to operate, namely, a control signal is sent to the motor driver 57, the motor M4 operates, the spraying heads of the spraying mechanism 66 are driven to spray one line of information on each medicine package, then, the motor M4 stops operating, the driving mechanism stops operating after carrying the medicine for a set time, the spraying heads of the spraying mechanism 66 are driven to spray one line of information on each medicine package, and the steps are repeated to spray the medicine taking time on the medicine packages. In the invention, the medicine taking time is sprayed on one surface of the medicine package. The sensor 41 detects the amount of the delivered medicine, and sends the measured information to the processor 51 for measurement, the dispensed amount is compared with the amount to be taken according to the prescription, when the prescribed amount is reached, a control signal is sent to the motor driver 65, so that the motor M1 drives the belt pressing mechanism 58 to operate, the belt pressing mechanism 58 drives the belt pressing shaft 39 to operate in the chute, so as to drive the belt pressing wheel 40 to be close to the supporting wheel 38, the belt pressing wheel 40 is in contact with the supporting wheel 38, and two sides of the medicine package at the rear in the string of medicine packages 100 are pressed tightly; meanwhile, the motor driver 64 sends a driving signal to the motor M2, the motor M2 continues to drive the medicine conveying mechanism 32 to rotate, the driving wheel 35 rotates together, the conveying belt 42 drives the driven wheel 36 to continue rotating and drives the front-side medicine package 100 to continue to run for a set time, and the front-side medicine package 100 continues to run because the rear-side package 100 of the adjacent medicine package 100 is pressed, so that the front-side package 100 is torn from the joint 101. The leading medication package 100 falls from the outlet 23 into the medication basket 63 of the medication basket delivery mechanism.
The control system further comprises a gate controller comprising a motor driver 59 and a sensor 61, the motor driver 59 being arranged to provide a drive signal to a motor M3 for driving operation of the gate control mechanism, the CPU being programmed to form a gate control module arranged to send a signal to the motor driver 59, the gate control module sending a control signal to the motor driver 59 after the processor 51 controls the dispensing mechanism to dispense a medicament into the cavity 24, the motor driver 59 sending a drive signal to motor M3, motor M3 driving the gate control mechanism 60 to open the door to the opening 19; after the sensor 61 detects that the medicine is taken away, the door control module sends a control signal to the motor driver 59 according to the information provided by the sensor 61, the motor driver 59 sends a driving signal to the motor M3, and the motor M3 drives the door control mechanism to close the door opening 19.
In the present invention, the sensor 41 communicates with the CPU to determine that the bar code 102, text or other readable information, is in a readable position. If the bar code 102, text or other readable information is not in a readable position, the CPU sends a control signal through the control motor driver 64 to drive the motor M2 to operate. The motor M2 then rotates in forward and reverse until the barcode 102 and/or text are in a readable position. The motor M2 is rotated in forward and reverse for a predetermined programmed amount of time. If after the time has elapsed, the barcode 102 and/or text remains unreadable, the drug dispensing device will notify the pharmacist that the package 100 is either empty or that there is a problem.
In accordance with the present invention, the medication dispensing apparatus may dispense any unreadable package 100 into the chamber 24 and attempt to read the next available package 100.
When the sensor 41 reads information from the text and/or barcode 102, the CPU communicates with the touch screen display 53 to visually display information about the medication within the medication package. After the drug dispensing device has dispensed the drug purchased by the user, the pharmacist is notified, for example by flashing a light bulb or touching the display 53.
Fig. 7 is a block diagram of a control system of an intelligent medicine box provided by the present invention, and as shown in fig. 7, the control system of the intelligent medicine box includes a CPU323, a main memory 315, a bridge device 314, an embedded processor 310, and a USB connector 320. The CPU323 is a processor that manages operation control of the intelligent cartridge and executes various programs loaded into the main memory 315. The various programs include an operating system OS that performs resource management of the smart cartridge, a driver that runs an application under the control of the OS, and a driver that performs operation control of various devices as hardware from software. The bridge circuit 314 is a device that relays reception and transmission of data performed between the CPU323, the main memory 315, and various devices. The embedded processor 310 is used to send the operation of the keyboard and pointing device to the CPU 323. The embedded processor 310 includes a function of starting/stopping the smart pill box in response to the on/off operation of the power button. In the invention, the CPU323 is connected with the main memory 315, the light-emitting device 321, the sound device 322, the box cover control circuit 316, the communication subsystem 324 and the near field matching circuit 325 through the bridging device 314, the CUP323 application program further operates the light-emitting device 321 and the sound device 322, so that when the medicine taking time is reached, the patient is reminded of the time of the past medicine taking through light and sound, the corresponding medicine box is opened according to whether the password input by the patient on the password card is qualified, and when the password verification is successful, an instruction is sent to the box cover control circuit 316, the control mechanism 319 of the box cover controls the box cover to open, so that the patient takes out the medicine and takes the taken out medicine. The subsystem 324 is used for the remote communication of the intelligent medicine box and a patient terminal, a health management department terminal, and the like, and the near field matching circuit 325 is used for the matching connection of the intelligent medicine box and the patient terminal, and the like through a near field protocol.
The control system of the smart medicine box further includes an input/output control circuit 311, a power supply circuit 318, a battery 317, a charging circuit 312, wherein a power supply line VBUS connected to the USB connector 320 is continued to the input/output control circuit 311. The input-output control circuit 311 is a switching circuit exclusively performing output of electric power to and input of electric power from the USB power line. The battery 317 is a secondary battery capable of repeated charge and discharge. The charging circuit 312 is a circuit that charges the battery 317 by using power input from the USB power line. When the smart medicine box is connected to the external power source, the power of the external power source is input to the charging circuit 317, and the charging circuit 312 charges the battery 18. Power supply circuit 318 outputs power from battery 317 to the circuitry of the intelligent pill box modules, circuits and devices.
The control system of the intelligent medicine box further comprises a password module B which is connected with the embedded processor 313 and is used for presetting the HMAC algorithm.
According to one embodiment, the cartridge is preferably made of food grade material that is resistant to mold, moisture and contamination.
Fig. 8 is a block diagram of a control system of a password card provided by the present invention, and as shown in fig. 3, the control system of the password card includes a bridge device 414, an embedded processor 410, a USB connector 417, an input/output control circuit 411, a charging circuit 412, a battery 415, and a power supply circuit 416, where the embedded processor 410 is connected to the embedded processor 310 of the smart cartridge via the bridge device 410, a data line of the USB connector 417, and the bridge device 314 of the smart cartridge. The input-output control circuit 411 is a switching circuit that exclusively performs output of electric power to and input of electric power from the USB power line. The battery 415 is a secondary battery capable of repeated charging and discharging. The charging circuit 412 is a circuit that charges the battery 415 by using power input from the USB power line. When the password card is connected to the smart pill box, power is input to the charging circuit 412, and the charging circuit 412 charges the battery 415. The power supply circuit 416 generates power from the battery 415 to be output to the password card modules and circuits.
The control system for the password card also includes an input keyboard 418 for the user to enter a medication code; it also includes a cryptographic module a, connected to the embedded processor 411, for presetting the HMAC algorithm.
Fig. 8 is an exemplary diagram showing the structure of the input/output control circuit. The input/ output control circuits 411 and 311 have the same configuration, and the input/output control circuit 411 will be described as an example. As shown in fig. 8, the input/output control circuit 311 includes two bus switches 161 and 162, and two backflow prevention circuits (diodes) D1 and D2. The bus switch 161 is provided on a power supply line in the input/output control circuit 311 to direct power generated by the power supply circuit 31 to the USB power supply line and to turn on or off the power supply line based on a control signal supplied from the embedded processor 310. A diode D1 to prevent reverse flow is provided at the output of the bus switch 161. In addition, the bus switch 162 is provided on a power supply line arranged in the input/output control circuit 311 to lead power input from the USB power supply line to the charging circuit 312, and to disconnect or cut off the power supply line based on a control signal (which is different from the control signal input to the bus switch 161) supplied from the embedded processor 310. A back flow prevention diode D2 is provided at the output of the bus switch 162. The input/output control circuit 311 forms a path from the power supply circuit 318 to the USB interface 320, the USB interface 417, the input/output control circuit 411 to the charging circuit 412, as indicated by arrows.
The operation of the mouthpiece when connected to the smart pill box will now be described. When the password card is connected to the USB connector 320 of the smart cartridge, the USB data lines D + and D-connect the smart cartridge, so the bridge circuit 314 senses that the password card is connected to the USB connector 320. The bridge circuit 314, which has sensed that the password card is connected to the USB connector 320, generates an interrupt signal and sends it to the CPU 323. Thus, the OS in the main memory 315 recognizes that the outlet card is connected to the USB connector 320. Firstly, an instruction is sent to the embedded processor 310 to drive and control the input/output control circuit 311, so that the bus switch 161 is turned off, the bus switch 162 is turned on, and the smart medicine box provides electric energy for the password card. Then, the embedded processor 310 is instructed to perform password authentication (the authentication process is described later) with the password card, and then the medicine box cover is opened to allow the patient to take the medicine.
In the invention, the password module password authentication process of the intelligent medicine box specifically comprises the following steps:
step 1: connecting the USB connector 320 of the intelligent medicine box with the USB connector 417 of the password card, receiving a medicine taking code input by a user by the embedded processor 410 of the password card, comparing the medicine taking code with the medicine taking code pre-stored in the password module A, sending a comparison result into the password module A, alarming and stopping working by the password card if the comparison is unsuccessful, and carrying out the step 2 if the comparison is successful, wherein the medicine taking code is a combination comprising numbers and/or letters.
Step 2, the password module A of the password card and the embedded processor of the intelligent medicine box carry out bidirectional password authentication; a password module A of the password card prestores a password KA, a password module B of the intelligent medicine box prestores a password KB, the password KA and the password KB have the same value, and the password module A and the password module B preset the same HMAC algorithm; the password module A and an embedded processor of the intelligent medicine box carry out two-way password authentication, and the whole authentication process is considered to be successful only when the two-way authentication is successful; if the authentication is unsuccessful, the password card gives an alarm and the intelligent medicine box stops working, if the authentication is successful, the step 3 is carried out, and the password KA and the password KB are the passwords distributed to the intelligent medicine box and the password card by the background server;
and 3, step 3: the embedded processor of the intelligent medicine box calculates the digest value of the embedded operating system image stored in the main memory, compares the digest value with the original digest value of the embedded operating system image stored in the password card of the password module A, if the comparison is unsuccessful, the password card gives an alarm and the intelligent medicine box stops working, and if the comparison is successful, the step 4 is carried out;
and 4, step 4: the intelligent medicine box opens the medicine box cover for the patient or the caregiver to take the medicine.
Preferably, the process of the bidirectional password authentication between the cryptographic module a and the embedded processor of the intelligent medicine box is as follows:
step 2-1: the cryptographic module A generates a random number RAAnd use a pre-stored password KAPerforming HMAC operation, and storing the operation result y1A＝HMAC(RA||KA) Wherein R isA||KARepresents the random number RAAnd a password KAThe cipher module A sends random number R to the embedded processor of the intelligent medicine boxA；
Step 2-2: the embedded processor of the intelligent medicine box uses the pre-stored password KBAnd received RAPerforming HMAC operation to obtain the result y1B＝HMAC(RA||KB) Wherein R isA||KBRepresents the random number RAAnd a password KBData connected together, the embedded processor of the intelligent medicine box sends y1 to the cryptographic module AB；
Step 2-3: cipher module A for received y1BAnd the saved operation result y1AComparing, if the two are the same, the verification is successful, the password module A sends the information of 'authentication passing' to the embedded processor of the intelligent medicine box, and the 2 nd step to the 4 th step are carried out; otherwise, the password module A sends authentication failure information to the embedded processor of the intelligent medicine box;
step 2-4: embedded processor of intelligent medicine box generates random number RBAnd use a pre-stored password KBPerforming HMAC operation, and storing the operation result y2B＝HMAC(RB||KB) Wherein R isB||KBRepresents the random number RBAnd a password KBThe data connected together, the embedded processor of the intelligent medicine box sends the random number R to the cipher module AB；
Step 2-5: the cipher module A uses the pre-stored password KAAnd received RBPerforming HMAC operation to obtain the result y2A＝HMAC(RB||KA) Wherein R isB||KARepresents the random number RBAnd a password KAData connected together, the cryptographic module A sends y2 to the embedded processor of the intelligent medicine boxA；
And 2, step 6: embedded processor of intelligent medicine box pair received y2AAnd the saved operation result y2BAnd comparing, if the two are the same, successfully verifying, and sending the 'authentication passing' information to the password module A by the embedded processor of the intelligent medicine box, otherwise, sending the 'authentication failure' information to the password module A by the embedded processor of the intelligent medicine box.
To achieve the above object, the present invention further provides a computer program that programs the above method into executable program code using a computer language. The present invention also provides a storage medium for storing the computer program, the storage medium including a network disk, an optical disk, and the like.
The cloud platform and the intelligent medicine box provided by the invention are matched with each other through the cooperation of the health management department, the patient and the intelligent medicine box, the medicine is automatically distributed according to the prescription, the safety is high, and the cloud platform and the intelligent medicine box are mainly used for managing the coronary heart disease and/or the patient.
In the invention, if the network is a 5G network, the forms of visual medicine taking, visual prescription and visual return diagnosis can be adopted.
In the invention, after the operations of intervention, replacement, transplantation and the like, the rejection resistance, the thrombus agglomeration resistance and the like are mainly monitored, and the prescription is adjusted according to the monitoring result.
In the invention, after the patient takes the medicine for a period of time in compliance, the following steps are carried out on the patient at the time of patient re-diagnosis: drug metabolism genome detection, blood concentration monitoring, key index monitoring and/or drug resistance detection to evaluate the treatment effect of the patient, and adjusting the prescription according to the detection result.
The drug metabolism genome detection is to detect drug metabolizing enzyme and drug action target gene of a patient by utilizing the known genomics theory. If the variation of the drug enzymes in drug metabolism occurs, the significant change of the blood concentration can be caused, thereby changing the pharmacokinetics and pharmacodynamics of the drug. The individual difference of the patient to the medicine can be accurately judged through the medicine gene detection. The drug effect, toxicity and other reactions of drug metabolizing enzyme and action target spot in the patient to the drug are predicted, so that the drug testing is avoided at the cost of the body, and accurate individual drug use is realized.
The blood concentration monitoring is to monitor the blood concentration of a patient with chronic diseases after taking the medicine, guide the clinical selection of the optimal treatment scheme and the optimal treatment dosage suitable for different individuals, and realize the reasonable medication guidance of the patient. The blood concentration refers to the total concentration of the drug in the plasma after absorption, and includes drugs bound to plasma proteins or free in the plasma, and sometimes also refers to the concentration of the drug in whole blood. The intensity of the drug action is proportional to the concentration of the drug in the plasma, which varies with time in vivo. The phenomenon is often found in clinical practice, the medicine with the same dosage is used for different patients suffering from the same diseases, the curative effect is very different, and some patients are just cured by the medicine; some curative effects are common, and the disease condition is slightly improved; some have poor curative effect. The toxic and side effects of the traditional Chinese medicine are different in manifestation, and some of the traditional Chinese medicine have few side effects or are slight; some are severely poisoned. This is because there are individual differences (age, sex, body condition, heredity, race, etc.). Different people have large variation of effective drug dosage, but small variation of safe and effective blood concentration. Generally, the ratio is about 1 time. When the blood concentration is higher than the safe and effective range, the toxic and side effects, the expression and the degree of the toxic and side effects are less changed in different patients.
The key index monitoring of chronic diseases is to realize the evaluation of patients after taking medicines for treatment by monitoring vital sign indexes, biochemical detection indexes and image indexes of different chronic patients.
The drug resistance detection is to detect the drug resistance of antibiotics (also called drug resistance) when aiming at acute complications, select a reasonable treatment scheme and reasonable medicine application and avoid the complications causing more than two chronic diseases.
It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are within the scope of the invention.

Claims (9)

1. A cloud platform system comprises a sanitation management department terminal, a patient terminal and an intelligent medicine box which are connected through a network, and are all configured with application programs, and is characterized in that the system configured by the sanitation management department terminal comprises a medicine distribution module which is configured to control medicine distribution equipment to distribute medicines to the intelligent medicine box and send a medicine taking schedule to the patient terminal and the intelligent terminal; an application program configured on the patient terminal controls the audio unit to pronounce according to the medicine taking schedule, and controls the display unit to display the medicine taking dosage and the medicines; the application program configured by the intelligent medicine box controls the sound device to sound and the light-emitting device to emit light according to the medicine taking schedule, and the application program configured by the intelligent medicine box further comprises a password authentication module which determines whether to open the medicine box cover according to the password card identification result of a patient or a caregiver.
2. The cloud platform system of claim 1, wherein the working process of the password authentication module comprises:
step 1: connecting a port of the password card with a connector of the intelligent medicine box, receiving a medicine taking code input by a user by the password card, comparing the medicine taking code with a prestored medicine taking code, sending a comparison result into a password module A, if the comparison is unsuccessful, giving an alarm by the password card and stopping working, and if the comparison is successful, performing the step 2;
step 2: the password module A of the password card and the embedded control processor of the intelligent medicine box carry out bidirectional password authentication; a password module A of the password card prestores a password KA, a password module B of the intelligent medicine box prestores a password KB, the password KA and the password KB have the same value, and the password module A and the password module B preset the same HMAC algorithm; the password module A and an embedded processor of the intelligent medicine box carry out two-way password authentication, and the whole authentication process is considered to be successful only when the two-way authentication is successful; if the authentication is unsuccessful, the password card stops working, and if the authentication is successful, the step 3 is carried out;
and 3, step 3: calculating the abstract value of the embedded operating system image stored in the intelligent medicine box main memory by the embedded processor of the password card, comparing the abstract value with the original abstract value of the embedded operating system image stored in the password module B of the intelligent medicine box, if the comparison is unsuccessful, alarming and stopping working by the password card, and if the comparison is successful, carrying out the step 4;
and 4, step 4: the box cover is opened to intelligence medicine box.
3. The cloud platform system of claim 2, wherein the process of bidirectional password authentication between the cryptographic module a and the embedded processor of the smart cartridge is as follows:
step 2-1: the cryptographic module A generates a random number RAAnd usePrestored password KAPerforming HMAC operation, and storing the operation result y1A＝HMAC(RA||KA) Wherein R isA||KARepresents the random number RAAnd a password KAThe cipher module A sends random number R to the embedded processor of the intelligent medicine boxA；
Step 2-2: the embedded processor of the intelligent medicine box uses the pre-stored password KBAnd received RAPerforming HMAC operation to obtain the result y1B＝HMAC(RA||KB) Wherein R isA||KBRepresents the random number RAAnd a password KBData connected together, the embedded processor of the intelligent medicine box sends y1 to the cryptographic module AB；
Step 2-3: cipher module A of intelligent medicine box for received y1BAnd the saved operation result y1AComparing, if the two are the same, the verification is successful, the password module A sends the information of 'authentication passing' to the embedded processor of the intelligent medicine box, and the 2 nd step to the 4 th step are carried out; otherwise, the password module A sends authentication failure information to the embedded processor of the intelligent medicine box;
step 2-4: embedded processor of intelligent medicine box generates random number RBAnd use a pre-stored password KBPerforming HMAC operation, and storing the operation result y2B＝HMAC(RB||KB) Wherein R isB||KBRepresents the random number RBAnd a password KBThe data connected together, the embedded processor of the intelligent medicine box sends the random number R to the cipher module AB；
Step 2-5: the cipher module A uses the pre-stored password KAAnd received RBPerforming HMAC operation to obtain the result y2A＝HMAC(RB||KA) Wherein R isB||KARepresents the random number RBAnd a password KAData connected together, the cryptographic module A sends y2 to the embedded processor of the intelligent medicine boxA；
And 2, step 6: embedded processor of intelligent medicine box pair received y2AAnd has already been protectedStored operation result y2BAnd comparing, if the two are the same, successfully verifying, and sending the 'authentication passing' information to the password module A by the embedded processor of the intelligent medicine box, otherwise, sending the 'authentication failure' information to the password module A by the embedded processor of the intelligent medicine box.
4. The cloud platform system of claim 3, wherein the medicine dispensing apparatus comprises a plurality of medicine dispensing devices, each medicine dispensing device comprises a medicine dispensing mechanism and a controller, the control system is connected with the terminal for pharmacy, the dispensing mechanism comprises a rotating shaft, a fixed shaft, a guide shaft and a belt pressing shaft which are arranged in parallel, two medicine package holding frames are movably arranged on the rotating shaft, the fixed shaft, the guide shaft and the belt pressing shaft, each holding frame is provided with a first through hole, a second through hole, a third through hole and a sliding groove along a first direction, a groove is arranged along a second direction, and the first direction is perpendicular to the second direction; the rotating shaft, the fixed shaft, the guide shaft and the belt pressing shaft are respectively inserted into the first through hole, the second through hole, the third through hole and the sliding groove, the rotating shaft and the fixed shaft are respectively provided with a driving wheel and a driven wheel at the positions of the grooves, the driving wheel is fixed on the rotating shaft, the driven wheel is movably sleeved on the fixed shaft, and the driving wheel and the driven wheel are provided with a transmission belt; the transmission belt is provided with bulges at equal intervals, and the diameter of the through hole of the medicine package is the same as that of the bulges; the guide shaft is inserted into the third through hole, and a support wheel is arranged at the position of the groove; the pressing shaft is inserted into the sliding groove, the pressing wheel is arranged at the position of the groove of the pressing shaft, and the pressing shaft moves in the sliding groove so that the pressing wheel presses the medicine package on the supporting wheel, or a certain gap is kept between the pressing wheel and the supporting wheel, so that the medicine package passes through the gap; the medicine distribution mechanism further comprises a driving mechanism and a belt pressing mechanism, the driving mechanism comprises a first motor and a first transmission mechanism, and the first motor drives the rotating shaft to rotate through the first transmission mechanism, so that the conveying belt carries medicine packages to operate; the belt pressing mechanism comprises a second motor and a second transmission mechanism, and the second motor drives the belt pressing shaft to move in the sliding groove through a second rotating machine, so that the medicine package passes through or does not pass through.
5. The cloud platform system of claim 4, wherein each drug dispensing mechanism dispenses a drug, the control system further comprising a plurality of sensors, each sensor for reading drug information of a drug package dispensed by a drug root mechanism; the control system also comprises a metering module, a comparison module and a control module, wherein the metering module is used for metering and distributing the medicine amount distributed by the distribution mechanism according to the information provided by the sensor; the comparison module is used for comparing the dispensed medicine quantity with the medicine quantity recorded in the prescription, and when the dispensed medicine quantity is smaller than the medicine quantity recorded in the prescription, the control module controls the dispensing mechanism to continuously dispense the medicine until the dispensed medicine quantity reaches the medicine quantity recorded in the prescription.
6. The crown cloud platform system according to claim 1, wherein the health management department terminal comprises at least a physician terminal and a pharmacy terminal, the physician terminal is configured with application programs, and the application programs comprise a patient treatment scheme making module, a medicine taking plan module, a patient follow-up plan making module and a return visit plan making module, wherein the patient treatment scheme making module and the medicine taking plan module are configured to record patient symptoms, issue a detection sheet, determine patient symptoms according to detection data, issue a treatment scheme and a prescription according to the patient symptoms; the follow-up patient planning module is configured to determine a follow-up plan according to patient symptoms; the re-diagnosis plan making module determines a re-diagnosis plan according to the symptoms of the patient; the application program configured by the terminal for the pharmacy receives the prescription of the doctor and controls the medicine distribution equipment to distribute the medicines to the electronic intelligent medicine boxes according to the prescription.
7. The cloud platform system of claim 6, wherein the patient terminal is configured with an application program comprising a patient module including at least a medicine taking module and a backlog module, the medicine taking module is configured to view a medicine taking plan, modify or view a medicine taking time, remind a patient to take medicine when the medicine taking time is reached, and request the patient to upload a medicine taking effect according to a prompt; the backlog module is configured to view the follow-up plan, select whether to accept follow-up visits and follow-up forms according to the prompt.
8. The cloud platform system according to any of claims 1-7, being used for managing coronary heart disease and/or patients thereof.
9. An intelligent medicine box in the cloud platform system according to any one of claims 1 to 9, which comprises a processor, a light-emitting device, an embedded processor, a sound device, a box cover driving mechanism, a communication subsystem and a memory, wherein the memory stores an application program, the processor calls the application program to implement the function of a medicine taking module in the application program, the medicine taking module is configured to control the sound device to sound according to a medicine taking schedule, control the light-emitting device to emit light, provide a control signal for the embedded processor of the medicine box to perform oral authentication on a password card of a user, and send a control signal to a box cover control circuit to drive the cover control mechanism to open a box cover after the authentication is passed, so that the user takes out a medicine to be taken.
CN202011100694.8A 2020-10-15 2020-10-15 Coronary heart disease management cloud platform system and intelligent medicine box Withdrawn CN112233759A (en)

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