CN112206209B - Acetylcysteine granules and preparation method thereof - Google Patents
Acetylcysteine granules and preparation method thereof Download PDFInfo
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- CN112206209B CN112206209B CN202010924964.0A CN202010924964A CN112206209B CN 112206209 B CN112206209 B CN 112206209B CN 202010924964 A CN202010924964 A CN 202010924964A CN 112206209 B CN112206209 B CN 112206209B
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- acetylcysteine
- percent
- menthol
- granules
- essence
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Images
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
acetylcysteine | 100(3.33%) |
Sucrose | 2766(92.2%) |
Menthol crystal | 24(0.8%) |
Stevia rebaudianum extract | 90(3.0%) |
Sweet orange essence | 20(0.67%) |
acetylcysteine | 180(6.0%) |
Sucrose | 2700(90.0%) |
Menthol | 45(1.5%) |
Stevia rebaudianum extract | 15(0.5%) |
Sweet orange essence | 60(2.0%) |
acetylcysteine | 90(3.0%) |
Sucrose | 2850(95.0%) |
Menthol crystal | 27(0.9%) |
Stevia rebaudianum extract | 18(0.6%) |
Sweet orange essence | 15(0.5%) |
acetylcysteine | 120(4.0%) |
Sucrose | 2781(92.7%) |
Menthol | 30(1.0%) |
Stevia rebaudianum extract | 24(0.8%) |
Sweet orange essence | 45(1.5%) |
acetylcysteine | 150(5.0%) |
Sucrose | 2774(92.46%) |
Menthol crystal | 36(1.2%) |
Stevia rebaudianum extract | 20(0.67%) |
Sweet orange essence | 20(0.67%) |
acetylcysteine | 100(3.33%) |
Sucrose | 2795(93.17%) |
Menthol crystal | 45(1.5%) |
Stevia rebaudianum extract | 30(1.0%) |
Sweet orange essence | 30(1.0%) |
Randomized grouping of test dogs | Taking medicine |
A(7,12,18,25,27,31) | Example 1 |
B(5,6,13,22,30,37) | Example 5 |
C(1,4,19,23,26,34,) | Example 6 |
D(2,11,15,21,33,38) | Comparative example 6-1 |
E(8,10,20,28,32,40) | Comparative examples 6 to 2 |
F(14,16,24,29,35,41) | Comparative examples 6 to 3 |
G(3,9,17,36,39,42) | Commercial control |
Claims (13)
Applications Claiming Priority (2)
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