CN112198654A - Illumination system for fluorescence image navigation operation - Google Patents
Illumination system for fluorescence image navigation operation Download PDFInfo
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- CN112198654A CN112198654A CN202011131600.3A CN202011131600A CN112198654A CN 112198654 A CN112198654 A CN 112198654A CN 202011131600 A CN202011131600 A CN 202011131600A CN 112198654 A CN112198654 A CN 112198654A
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- laser
- lighting device
- illumination system
- motor
- fluoroscopic image
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
- G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
- G02B23/2407—Optical details
- G02B23/2461—Illumination
- G02B23/2469—Illumination using optical fibres
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
- A61B2034/2046—Tracking techniques
- A61B2034/2055—Optical tracking systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
- A61B2034/2046—Tracking techniques
- A61B2034/2055—Optical tracking systems
- A61B2034/2057—Details of tracking cameras
Abstract
The invention discloses an illumination system for a fluorescence image navigation operation, which comprises a host, a laser illumination device and an LED illumination device, wherein the host is connected with the laser illumination device; the laser lighting device comprises a laser surface light source, a laser collimator, a laser beam expander, a reflector and a spectroscope, wherein light rays emitted by the laser surface light source sequentially pass through the collimator, the beam expander, the reflector and the spectroscope and then reach the affected part; the LED lighting device comprises a plurality of white LED lamps which are annularly arranged; the host is respectively in signal connection with the laser lighting device and the LED lighting device, and laser is reflected twice by the reflector and the notch dichroic mirror and then is emitted in the direction that the central axis of the light beam is coincided with the optical axis of the corresponding imaging system, so that the proportion of the laser coverage field can achieve 100% coverage under the working distance; in addition, the annular LED white light is designed to remove possible fluorescent components in the white light through a 770nm short-wave pass filter, so that background fluorescent noise is reduced.
Description
Technical Field
The invention relates to the technical field of fluorescence image navigation surgery, in particular to an illumination system for fluorescence image navigation surgery.
Background
Malignant tumor is an important disease threatening human health, and surgery is the first-choice accurate treatment scheme for tumor patients, however, about 40% of patients can not achieve R0 resection in surgery (i.e. no residue under microscope after resection) according to statistics, and the annual recurrence rate after surgery is as high as 60%, and the main reason is that the existing detection means such as MRI, PET-CT and the like can not image in real time in surgery, and doctors can only determine the resection scheme by experience in surgery. Currently, accurate treatment of malignant tumors is a hot spot in medical research, wherein near infrared fluorescence navigation surgery is the most promising technology for solving the problem with real-time and high accuracy, and the technologies generally include two types of apparatuses: the device suitable for the open surgery and the device suitable for the minimally invasive endoscopic surgery are applied to the fields of oral cancer, liver cancer, thyroid cancer and the like, but have the problems of large volume, difficulty in operation and limited observation angle of doctors, and more integrated portable devices are needed to observe tumor fluorescence more flexibly. The existing open surgery equipment is large in size, and the range of laser illumination is limited due to the working distance in the surgery, so that the laser coverage field is small; in addition, the fluorescent background caused by the white light can also generate interference, so that the sensitivity of the device is reduced.
Disclosure of Invention
The invention aims to provide an illumination system for a fluorescence image navigation operation, and aims to solve the problems that the range of laser illumination is limited and fluorescence background interference is caused by white light in the prior art.
In order to achieve the purpose, the invention provides an illumination system for a fluorescence image navigation operation, which comprises a host machine, a laser illumination device and an LED illumination device; the laser lighting device comprises a laser surface light source, a laser collimator, a laser beam expander, a reflector and a spectroscope, wherein light rays emitted by the laser surface light source sequentially pass through the collimator, the beam expander, the reflector and the spectroscope and then reach the affected part; the LED lighting device comprises a plurality of white LED lamps which are annularly arranged; and the host computer is respectively connected with the laser lighting device and the LED lighting device through signals.
Preferably, the LED lighting device further comprises a 770nm short-wave filter sheet, and the divergence angle of each white LED lamp is 60 degrees.
Preferably, the laser area light source comprises a 785nm solid-state laser and a 785nm band-pass filter.
Preferably, the laser surface light source is connected with the laser collimator through an optical fiber bundle, and the optical fiber bundle comprises a plurality of round-cornered optical fibers with rectangular cross sections.
Preferably, the laser beam expander comprises a concave lens, a convex lens and a sleeve, and the concave lens and the convex lens are both arranged in the sleeve.
Preferably, the laser beam expander further comprises a first motor, the first motor is used for adjusting the distance between the concave lens and the convex lens, and the first motor is installed in the sleeve and is in signal connection with the host machine.
Preferably, the optical fiber beam splitter further comprises a second motor, the second motor is used for driving the beam splitter to rotate so as to adjust the angle of the beam splitter, and the second motor is in signal connection with the host.
Preferably, the dichroic mirror is a 780nm notch reflective dichroic mirror.
Preferably, the notch half-peak width is 20 nm.
Preferably, the mirror device further comprises a third motor, the third motor is used for driving the mirror to rotate so as to adjust the angle of the mirror, and the third motor is in signal connection with the host machine.
Compared with the prior art, the invention has the advantages that:
after being reflected twice by the reflecting mirror and the notch dichroic mirror, the laser is emitted just in the direction that the central axis of the light beam is superposed with the optical axis of the corresponding imaging system, so that the proportion of the laser coverage field can achieve 100 percent coverage under the working distance; in addition, the annular LED white light is designed to remove possible fluorescent components in the white light through a 770nm short-wave pass filter, so that background fluorescent noise is reduced.
Drawings
FIG. 1 is a schematic view of a laser illumination device of the illumination system for fluoroscopic image guided surgery according to the present invention;
FIG. 2 is a schematic view of an LED lighting device of the lighting system for fluoroscopic image guided surgery according to the present invention.
The reference numbers in the figures illustrate:
1. a laser area light source; 2. a fiber optic bundle; 3. a laser collimator; 4. a laser beam expander; 5. a concave lens; 6. a convex lens; 7. a mirror; 8. a beam splitter; 9. an affected part; 10. 770nm short-wave pass filter; 11. an LED lighting device.
Detailed Description
The technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention; it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and all other embodiments obtained by those skilled in the art without any inventive work are within the scope of the present invention.
In the description of the present invention, it should be noted that the terms "upper", "lower", "inner", "outer", "top/bottom", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus should not be construed as limiting the present invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it should be noted that, unless otherwise specifically stated or limited, the terms "mounted," "disposed," "sleeved/connected," "connected," and the like are used in a broad sense, and for example, "connected" may be a fixed connection, a detachable connection, an integral connection, a mechanical connection, an electrical connection, a direct connection, an indirect connection through an intermediate medium, and a communication between two elements.
Referring to fig. 1 and 2, an illumination system for fluoroscopic image guided surgery includes a main machine (not shown), a laser illumination device and an LED illumination device 11; the laser lighting device comprises a laser surface light source 1, a laser collimator 3, a laser beam expander 4, a reflecting mirror 7 and a spectroscope 8, wherein light rays emitted by the laser surface light source 1 sequentially pass through the laser collimator 3, the laser beam expander 4, the reflecting mirror 7 and the spectroscope 8 and then reach an affected part 9; the LED lighting device 11 includes a plurality of white LED lamps (not shown) arranged in a ring shape; and the host computer is respectively connected with the laser lighting device and the LED lighting device 11 through signals.
The laser lighting device and the LED lighting device 11 are part of the lighting system for fluoroscopic image guided surgery, and for better description of the lighting system for fluoroscopic image guided surgery, the laser lighting device and the LED lighting device 11 are described by using fig. 1 and fig. 2, respectively.
Preferably, the LED lighting device 11 further includes a 770nm short-wave pass filter 10, and the divergence angle of each white LED lamp is 60 degrees, the emitted white light can provide uniform visible light illumination, and has a partial shadow removing effect; in addition, after being filtered by the 770nm short-wave pass filter 10, the fluorescence interference emitted by the non-fluorescent substance can be reduced as much as possible, and the authenticity of a fluorescence signal is ensured.
Preferably, the laser surface light source 1 includes a 785nm solid-state laser (not shown) and a 785nm band-pass filter (not shown); the laser surface light source 1 is connected with a laser collimator 3 through an optical fiber bundle 2, and the optical fiber bundle 2 comprises a plurality of round-cornered optical fibers with rectangular cross sections.
The laser generated by the 785nm solid laser is filtered by the 785nm band-pass filter to remove stray light possibly generated in other wave bands, then is coupled into the optical fiber bundle 2, and is subjected to multiple total reflection, and the outlet of the laser is positioned on the focal plane of the laser collimator 3, so that the laser becomes a quasi-parallel uniform light beam after passing through the optical fiber bundle 2 and the laser collimator 3.
The laser beam expander 4 comprises a concave lens 5, a convex lens 6 and a sleeve (not shown), the concave lens 5 and the convex lens 6 being mounted within the sleeve; the laser beam expander 4 further comprises a first motor (not shown) for adjusting the distance between the concave lens 5 and the convex lens 6, the first motor is installed in the sleeve and is in signal connection with a host, the first motor can be driven by the host according to actual needs, and the distance between the concave lens 5 and the convex lens 6 is adjusted, so that the beam expanding proportion is adjusted.
Preferably, the device further comprises a second motor (not shown), the second motor is used for driving the spectroscope 8 to rotate so as to adjust the angle of the spectroscope 8, and the second motor is in signal connection with the host; the spectroscope 8 is a 780nm notch reflection dichroic mirror, the notch half-peak width is 20nm, and the 780nm notch reflection dichroic mirror can reflect 785nm laser more than 98%, so that visible light and fluorescence can pass through more than 95%.
Further, a third motor (not shown) is included, the third motor is used for driving the reflecting mirror 7 to rotate so as to adjust the angle of the reflecting mirror 7, and the third motor is in signal connection with a host machine.
The reflecting mirror 7 and the 780nm notch reflective dichroic mirror preferably form an angle of 45 degrees with the central axis of the light beam, and the quasi-parallel light beam is reflected by the reflecting mirror 7 and the 780nm notch reflective dichroic mirror in sequence to become a divergent laser beam with a large area.
Because the host computer is connected with laser lighting device and LED lighting device 11 signal respectively, can in time adjust the power and the illumination initial time of laser lighting device and LED lighting device 11 as required, improved work efficiency.
785nm laser is reflected twice by the reflecting mirror 7 and the notch dichroic mirror, and then is emitted in the direction that the central axis of the light beam coincides with the optical axis of the corresponding imaging system, so that the coaxial laser illumination effect is achieved. Because the laser light source is arranged externally, the proportion of the laser coverage field of vision can not be changed due to the focusing of the lens, and is determined by the size of an emergent light spot and the divergence angle of a light beam, and the size of the emergent light spot can be adjusted by the laser beam expander 4, so that the proportion of the laser coverage field of vision can be 100 percent covered under the working distance, the problem that the illumination range of exciting light in the existing fluorescence navigation operation is limited by the working distance is solved, the coaxial illumination of the exciting light is completely consistent with the imaging field of vision, and the affected part 9 in the field of vision can be ensured to be covered by; in addition, the annular LED white light is designed to remove possible fluorescent components in the white light through the 770nm short-wave pass filter 10, so that background fluorescent noise is reduced. The two aspects ensure the purity of the signal source of the illumination system in the fluorescence image navigation operation, thereby improving the sensitivity of the whole imaging system. In addition, the illumination technology system is convenient to integrate, can be used for the miniaturized design of the fluorescence image navigation equipment, and further promotes the application of the fluorescence image navigation operation technology in open type operations.
The foregoing is only a preferred embodiment of the present invention; the scope of the invention is not limited thereto. Any person skilled in the art should be able to cover the technical scope of the present invention by equivalent or modified solutions and modifications within the technical scope of the present invention.
Claims (10)
1. An illumination system for fluoroscopic image guided surgery, comprising: the LED lighting device comprises a host, a laser lighting device and an LED lighting device; the laser lighting device comprises a laser surface light source, a laser collimator, a laser beam expander, a reflector and a spectroscope, wherein light rays emitted by the laser surface light source sequentially pass through the collimator, the beam expander, the reflector and the spectroscope and then reach the affected part; the LED lighting device comprises a plurality of white LED lamps which are annularly arranged; and the host computer is respectively connected with the laser lighting device and the LED lighting device through signals.
2. The illumination system for fluoroscopic image guided surgery according to claim 1, characterized in that: the LED lighting device also comprises a 770nm short wave filter sheet, and the divergence angle of each white light LED lamp is 60 degrees.
3. The illumination system for fluoroscopic image guided surgery according to claim 1, characterized in that: the laser surface light source comprises a 785nm solid laser and a 785nm band-pass filter.
4. The illumination system for fluoroscopic image guided surgery according to claim 3, characterized in that: the laser surface light source is connected with the laser collimator through an optical fiber bundle, and the optical fiber bundle comprises a plurality of round-angle optical fibers with rectangular cross sections.
5. The illumination system for fluoroscopic image guided surgery according to claim 1, characterized in that: the laser beam expander comprises a concave lens, a convex lens and a sleeve, and the concave lens and the convex lens are both arranged in the sleeve.
6. The illumination system for fluoroscopic image guided surgery according to claim 5, characterized in that: the laser beam expander also comprises a first motor, the first motor is used for adjusting the distance between the concave lens and the convex lens, and the first motor is installed in the sleeve and is in signal connection with the host machine.
7. The illumination system for fluoroscopic image guided surgery according to claim 1, characterized in that: the laser beam splitter further comprises a second motor, the second motor is used for driving the beam splitter to rotate so as to adjust the angle of the beam splitter, and the second motor is in signal connection with the host.
8. The illumination system for fluoroscopic image guided surgery according to claim 7, characterized in that: the spectroscope is a 780nm notch reflection dichroic mirror.
9. The illumination system for fluoroscopic image guided surgery according to claim 8, characterized in that: the notch half-peak width is 20 nm.
10. The illumination system for fluoroscopic image guided surgery according to claim 1, characterized in that: the mirror angle adjusting device further comprises a third motor, the third motor is used for driving the mirror to rotate so as to adjust the angle of the mirror, and the third motor is in signal connection with the host machine.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011131600.3A CN112198654B (en) | 2020-10-21 | 2020-10-21 | Illumination system for fluorescence image navigation operation |
| PCT/CN2020/132364 WO2022082931A1 (en) | 2020-10-21 | 2020-11-27 | Illumination system for fluorescence imaging-navigated surgery |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN202011131600.3A CN112198654B (en) | 2020-10-21 | 2020-10-21 | Illumination system for fluorescence image navigation operation |
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| CN112198654A true CN112198654A (en) | 2021-01-08 |
| CN112198654B CN112198654B (en) | 2022-11-15 |
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| CN202011131600.3A Active CN112198654B (en) | 2020-10-21 | 2020-10-21 | Illumination system for fluorescence image navigation operation |
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| CN (1) | CN112198654B (en) |
| WO (1) | WO2022082931A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113589521A (en) * | 2021-07-19 | 2021-11-02 | 中国人民解放军总医院第四医学中心 | Refractive surgical eyepiece |
| CN115316961A (en) * | 2022-10-14 | 2022-11-11 | 南京诺源医疗器械有限公司 | Fluorescent image probe and handheld image detector |
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| WO2022082931A1 (en) | 2022-04-28 |
| CN112198654B (en) | 2022-11-15 |
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