CN112190473A - Wet granulation device for chiral drug preparation and use method thereof - Google Patents
Wet granulation device for chiral drug preparation and use method thereof Download PDFInfo
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- CN112190473A CN112190473A CN202011041621.6A CN202011041621A CN112190473A CN 112190473 A CN112190473 A CN 112190473A CN 202011041621 A CN202011041621 A CN 202011041621A CN 112190473 A CN112190473 A CN 112190473A
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- rotating shaft
- wet granulation
- straight pipe
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- tank body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
Abstract
The invention discloses a wet granulation device for chiral drug preparation and a using method thereof, and the wet granulation device comprises a tank device for containing raw materials and an upper cover device for sealing the tank device, wherein a discharge device for discharging formed particles is installed on one side of the tank device, a granulating device for cutting the raw materials into granules is installed on one side of the tank device, which is far away from the discharge device, and a stirring device for stirring the raw materials is installed at the bottom of the tank device. The invention ensures the cleanness of the chiral medicine preparation through the integral sealing arrangement; due to the arrangement of negative pressure suction, the chiral medicine preparation raw materials are ensured to smoothly enter the main tank body without being touched, and the cleanness is ensured; through the arrangement of automatic discharging, the automatic discharging of the formed particles is ensured, and the pollution is avoided.
Description
Technical Field
The invention relates to the technical field of chiral drug preparation, in particular to a wet granulation device for chiral drug preparation and a use method thereof.
Background
Generally, chiral drugs can be obtained by extraction from natural products and resolution of racemates, in recent years, with the development of synthesis methods and the emergence of advanced analysis techniques, more and more chiral compounds can be asymmetrically synthesized by chemical synthesis methods, which is an important means for obtaining chiral substances, and meanwhile, with the continuous progress of biotechnology and the cross fusion of biotechnology and organic chemistry, biosynthesis is also a key technology for making breakthrough in chiral drug production. And finally the chiral drug material needs to be granulated for use.
However, in the prior art, the wet granulation device for preparing the chiral drug is generally open, which results in that: 1. the cleanness of the chiral medicine preparation cannot be ensured because the chiral medicine is not integrally sealed; 2. the chiral medicine preparation raw materials are poured into the main tank body, so that the cleanness cannot be guaranteed; 3. the arrangement of automatic discharging is not available, the formed particles can not be automatically discharged, and the pollution is easy to happen.
Disclosure of Invention
The invention aims to solve the problems and provide a wet granulation device for preparing a chiral drug and a using method thereof.
The invention realizes the purpose through the following technical scheme:
a wet granulation device for chiral drug preparation comprises a tank device for containing raw materials and an upper cover device for sealing the tank device, wherein a discharge device for discharging formed particles is installed on one side of the tank device, a granulating device for cutting off the raw materials for granulation is installed on one side, away from the discharge device, of the tank device, and a stirring device for stirring the raw materials is installed at the bottom of the tank device; the tank body device comprises a main tank body, wherein 4 supporting legs are uniformly distributed at the bottom of the main tank body, a discharge pipe is arranged on one side of the main tank body, a motor base is arranged on one side of the main tank body, which is far away from the discharge pipe, and a sealing gasket is adhered to the top of the main tank body; the upper cover device comprises a sealing cover, wherein 2 first straight pipes are symmetrically arranged on the sealing cover, a first electrovalve is arranged in the middle of each first straight pipe, a second straight pipe is arranged on one side of each first straight pipe, a second electrovalve is arranged in the middle of each second straight pipe, a flexible rubber pipe is arranged on each first straight pipe, a hard straight pipe is arranged behind each flexible rubber pipe, and a vacuum air pump is arranged below each hard straight pipe; the discharging device comprises a supporting plate, a telescopic cylinder is arranged on the supporting plate, and a sealing plug is arranged at one end of the telescopic cylinder; cut grain device and include first motor, first pivot is installed to first motor one side, evenly distributed has a plurality of cutting pieces in the first pivot.
Preferably: the stirring device comprises a second rotating shaft, a plurality of stirring blades are uniformly distributed on the second rotating shaft, a large belt wheel is installed below the second rotating shaft, a small belt wheel is arranged on one side of the large belt wheel, a transmission belt is installed between the large belt wheel and the small belt wheel, and a second motor is installed below the small belt wheel.
According to the arrangement, the second motor drives the small belt wheel to drive the large belt wheel to rotate through the transmission belt, and the large belt wheel drives the stirring blades to stir through the second rotating shaft.
Preferably: the stirring device comprises a second rotating shaft, a plurality of stirring blades are uniformly distributed on the second rotating shaft, a large gear is installed below the second rotating shaft, a small gear is arranged on one side of the large gear, and a second motor is installed below the small gear.
So set up, the second motor drive the pinion meshing the gear wheel is rotatory, the gear wheel passes through the second pivot drives the stirring leaf stirs.
Preferably: the supporting legs, the discharge pipe and the motor base are welded with the main tank body respectively.
So set up, the welding has guaranteed the supporting leg arrange the material pipe with the motor cabinet is firm reliable.
Preferably: the first straight pipe and the second straight pipe are welded with the sealing cover respectively, and the soft rubber pipe and the hard straight pipe are connected with the first straight pipe through a clamping hoop respectively.
So set up, the welding has guaranteed first straight tube with the second straight tube is firm reliable, and clamp connection is convenient for the dismouting change the flexible glue pipe with hard straight tube.
Preferably: the backup pad with arrange material pipe bolted connection, telescopic cylinder respectively with the backup pad with sealing plug bolted connection.
So set up, bolted connection is convenient for the dismouting the backup pad with telescopic cylinder.
Preferably: the first motor is connected with the motor base through bolts, the first rotating shaft is connected with the first motor through flat keys, and the cut-off pieces are welded with the first rotating shaft together.
So set up, bolted connection is convenient for dismouting maintenance first motor, the parallel key connection has guaranteed first motor drive first pivot is rotatory, and the welding has guaranteed the cut-off piece is firm reliable.
Preferably: the stirring blade is welded with the second rotating shaft, the large belt wheel is connected with the second rotating shaft through a flat key, and the small belt wheel is connected with the second motor through a flat key.
So set up, the welding has guaranteed the stirring leaf is firm reliable, and the parallel key connection has guaranteed the second motor drive little band pulley is rotatory, big band pulley drive the second pivot is rotatory.
Preferably: the stirring blades are welded with the second rotating shaft, the large gear is connected with the second rotating shaft through a flat key, and the small gear is connected with the second motor through a flat key.
So set up, the welding has guaranteed the stirring leaf is firm reliable, and the parallel key connection has guaranteed the second motor drive the pinion is rotatory, big gear drive the second pivot is rotatory.
The invention also provides a using method of the wet granulation device for preparing the chiral drug, which comprises the following steps:
a. firstly, opening the first electrovalve, pumping air in the main tank body through the hard straight pipe by the vacuum air pump to form vacuum suction, sucking the raw materials into the main tank body through the soft rubber pipe by the vacuum suction, and closing the first electrovalve;
b. then starting the stirring device to stir the raw materials, simultaneously opening the second electrovalve, and spraying auxiliary liquid into the main tank body through the second straight pipe to bond the raw materials;
c. then the first motor drives the cutting piece to rotate through the first rotating shaft, the bonded raw materials are cut off, and particles are formed under the coordination of continuous overturning and cutting;
d. and finally, the telescopic cylinder drives the sealing plug to be opened, so that the formed particles are discharged along the discharge pipe.
Compared with the prior art, the invention has the following beneficial effects:
1. the cleanness of the chiral medicine preparation is ensured through the integral sealing arrangement;
2. due to the arrangement of negative pressure suction, the chiral medicine preparation raw materials are ensured to smoothly enter the main tank body without being touched, and the cleanness is ensured;
3. through the arrangement of automatic discharging, the automatic discharging of the formed particles is ensured, and the pollution is avoided.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.
FIG. 1 is a schematic structural diagram of a wet granulation apparatus for preparing a chiral drug according to the present invention;
FIG. 2 is a front perspective view of a wet granulation apparatus for the preparation of a chiral drug according to the present invention;
FIG. 3 is a front perspective view of a tank assembly of a wet granulation apparatus for chiral drug preparation in accordance with the present invention;
FIG. 4 is a schematic diagram of the upper cover device of the wet granulation device for preparing chiral drugs according to the present invention;
FIG. 5 is a schematic view of a discharge device of a wet granulation apparatus for preparing a chiral drug according to the present invention;
FIG. 6 is a schematic view of a granulating apparatus of a wet granulation apparatus for chiral drug preparation according to the present invention;
FIG. 7 is a schematic view of a stirring device of example 1 of a wet granulation device for preparing a chiral drug according to the present invention;
FIG. 8 is a schematic view of a stirring device in example 2 of a wet granulation device for preparing a chiral drug according to the present invention.
The reference numerals are explained below:
1. a tank means; 101. a main tank body; 102. supporting legs; 103. a discharge pipe; 104. a motor base; 105. a gasket; 2. a cover mounting means; 201. a sealing cover; 202. a first straight pipe; 203. a first electrovalve; 204. a soft rubber tube; 205. a hard straight pipe; 206. a second straight pipe; 207. a second electrovalve; 208. a vacuum air pump; 3. a discharge device; 301. a support plate; 302. a telescopic cylinder; 303. a sealing plug; 4. a granulating device; 401. a first motor; 402. a first rotating shaft; 403. cutting off the slices; 5. a stirring device; 501. a second rotating shaft; 502. stirring blades; 503. a second motor; 504. a large belt pulley; 505. a small belt pulley; 506. a transmission belt; 507. a bull gear; 508. a pinion gear.
Detailed Description
In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on those shown in the drawings, and are used only for convenience in describing the present invention and for simplicity in description, and do not indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and thus, are not to be construed as limiting the present invention. Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," etc. may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless otherwise specified.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art through specific situations.
The invention will be further described with reference to the accompanying drawings in which:
example 1
As shown in fig. 1-7, a wet granulation apparatus for preparing chiral drugs comprises a tank device 1 for containing raw materials and an upper cover device 2 for closing the tank device 1, wherein a discharge device 3 for discharging formed particles is installed on one side of the tank device 1, a granulation device 4 for cutting off the raw materials into granules is installed on one side of the tank device 1 away from the discharge device 3, and a stirring device 5 for stirring the raw materials is installed at the bottom of the tank device 1; the tank device 1 comprises a main tank body 101, 4 supporting legs 102 are uniformly distributed at the bottom of the main tank body 101, a discharge pipe 103 is arranged on one side of the main tank body 101, a motor base 104 is arranged on one side, away from the discharge pipe 103, of the main tank body 101, and a sealing gasket 105 is adhered to the top of the main tank body 101; the upper cover device 2 comprises a sealing cover 201, 2 first straight pipes 202 are symmetrically arranged on the sealing cover 201, a first electric valve 203 is arranged in the middle of each first straight pipe 202, a second straight pipe 206 is arranged on one side of each first straight pipe 202, a second electric valve 207 is arranged in the middle of each second straight pipe 206, a soft rubber pipe 204 is arranged on each first straight pipe 202, a hard straight pipe 205 is arranged behind each soft rubber pipe 204, and a vacuum air pump 208 is arranged below each hard straight pipe 205; the discharging device 3 comprises a supporting plate 301, a telescopic cylinder 302 is arranged on the supporting plate 301, and a sealing plug 303 is arranged at one end of the telescopic cylinder 302; the granulating device 4 comprises a first motor 401, a first rotating shaft 402 is installed on one side of the first motor 401, and a plurality of cutting blades 403 are uniformly distributed on the first rotating shaft 402.
Preferably: the stirring device 5 comprises a second rotating shaft 501, a plurality of stirring blades 502 are uniformly distributed on the second rotating shaft 501, a large belt wheel 504 is arranged below the second rotating shaft 501, a small belt wheel 505 is arranged on one side of the large belt wheel 504, a transmission belt 506 is arranged between the large belt wheel 504 and the small belt wheel 505, and a second motor 503 is arranged below the small belt wheel 505; the supporting legs 102, the discharge pipe 103 and the motor base 104 are respectively welded with the main tank body 101; the first straight pipe 202 and the second straight pipe 206 are welded with the sealing cover 201 respectively, and the soft rubber pipe 204 and the hard straight pipe 205 are connected with the first straight pipe 202 in a clamping manner respectively; the supporting plate 301 is connected with the discharging pipe 103 through a bolt, and the telescopic cylinder 302 is respectively connected with the supporting plate 301 and the sealing plug 303 through a bolt; the first motor 401 is connected with the motor base 104 through bolts, the first rotating shaft 402 is connected with the first motor 401 through flat keys, and the cut piece 403 is welded with the first rotating shaft 402; the stirring blade 502 is welded with the second rotating shaft 501, the large belt wheel 504 is in flat key connection with the second rotating shaft 501, and the small belt wheel 505 is in flat key connection with the second motor 503.
Example 2
As shown in fig. 8, embodiment 2 differs from embodiment 1 in that: the stirring device 5 comprises a second rotating shaft 501, a plurality of stirring blades 502 are uniformly distributed on the second rotating shaft 501, a large gear 507 is arranged below the second rotating shaft 501, a small gear 508 is arranged on one side of the large gear 507, and a second motor 503 is arranged below the small gear 508; the stirring blade 502 and the second rotating shaft 501 are welded together, the large gear 507 is in flat key connection with the second rotating shaft 501, and the small gear 508 is in flat key connection with the second motor 503.
The invention also provides a using method of the wet granulation device for preparing the chiral drug, which comprises the following steps:
a. firstly, opening a first electric valve 203, pumping air in the main tank body 101 by a vacuum air pump 208 through a hard straight pipe 205 to form vacuum suction force, sucking raw materials into the main tank body 101 by the vacuum suction force through a soft rubber pipe 204, and closing the first electric valve 203;
b. then, starting the stirring device 5 to stir the raw materials, simultaneously opening the second electrovalve 207, and spraying auxiliary liquid into the main tank 101 through the second straight pipe 206 to bond the raw materials;
c. then, the first motor 401 drives the cutting piece 403 to rotate through the first rotating shaft 402, the bonded raw materials are cut off, and particles are formed under the coordination of continuous overturning and cutting;
d. finally, the telescopic cylinder 302 drives the sealing plug 303 to open, so that the molded particles are discharged along the discharge pipe 103.
The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed.
Claims (10)
1. The utility model provides a wet granulation device of chiral drugs preparation, is including the jar body device that is used for holding the raw materials, its characterized in that: the device also comprises an upper cover device used for sealing the tank device, a discharging device used for discharging formed particles is arranged on one side of the tank device, a granulating device used for cutting raw materials into granules is arranged on one side of the tank device, which is far away from the discharging device, and a stirring device used for stirring the raw materials is arranged at the bottom of the tank device;
the tank body device comprises a main tank body, wherein 4 supporting legs are uniformly distributed at the bottom of the main tank body, a discharge pipe is arranged on one side of the main tank body, a motor base is arranged on one side of the main tank body, which is far away from the discharge pipe, and a sealing gasket is adhered to the top of the main tank body;
the upper cover device comprises a sealing cover, wherein 2 first straight pipes are symmetrically arranged on the sealing cover, a first electrovalve is arranged in the middle of each first straight pipe, a second straight pipe is arranged on one side of each first straight pipe, a second electrovalve is arranged in the middle of each second straight pipe, a flexible rubber pipe is arranged on each first straight pipe, a hard straight pipe is arranged behind each flexible rubber pipe, and a vacuum air pump is arranged below each hard straight pipe;
the discharging device comprises a supporting plate, a telescopic cylinder is arranged on the supporting plate, and a sealing plug is arranged at one end of the telescopic cylinder;
cut grain device and include first motor, first pivot is installed to first motor one side, evenly distributed has a plurality of cutting pieces in the first pivot.
2. The wet granulation device for preparing chiral drugs according to claim 1, wherein: the stirring device comprises a second rotating shaft, a plurality of stirring blades are uniformly distributed on the second rotating shaft, a large belt wheel is installed below the second rotating shaft, a small belt wheel is arranged on one side of the large belt wheel, a transmission belt is installed between the large belt wheel and the small belt wheel, and a second motor is installed below the small belt wheel.
3. The wet granulation device for preparing chiral drugs according to claim 1, wherein: the stirring device comprises a second rotating shaft, a plurality of stirring blades are uniformly distributed on the second rotating shaft, a large gear is installed below the second rotating shaft, a small gear is arranged on one side of the large gear, and a second motor is installed below the small gear.
4. The wet granulation device for preparing chiral drugs according to claim 1, wherein: the supporting legs, the discharge pipe and the motor base are welded with the main tank body respectively.
5. The wet granulation device for preparing chiral drugs according to claim 1, wherein: the first straight pipe and the second straight pipe are welded with the sealing cover respectively, and the soft rubber pipe and the hard straight pipe are connected with the first straight pipe through a clamping hoop respectively.
6. The wet granulation device for preparing chiral drugs according to claim 1, wherein: the backup pad with arrange material pipe bolted connection, telescopic cylinder respectively with the backup pad with sealing plug bolted connection.
7. The wet granulation device for preparing chiral drugs according to claim 1, wherein: the first motor is connected with the motor base through bolts, the first rotating shaft is connected with the first motor through flat keys, and the cut-off pieces are welded with the first rotating shaft together.
8. The wet granulation device for preparing chiral drugs according to claim 2, wherein: the stirring blade is welded with the second rotating shaft, the large belt wheel is connected with the second rotating shaft through a flat key, and the small belt wheel is connected with the second motor through a flat key.
9. The wet granulation device for preparing chiral drugs according to claim 3, wherein: the stirring blades are welded with the second rotating shaft, the large gear is connected with the second rotating shaft through a flat key, and the small gear is connected with the second motor through a flat key.
10. The use method of the wet granulation device for preparing the chiral drug according to any one of claims 1 to 9, is characterized in that the specific use method comprises the following steps:
a. firstly, opening the first electrovalve, pumping air in the main tank body through the hard straight pipe by the vacuum air pump to form vacuum suction, sucking the raw materials into the main tank body through the soft rubber pipe by the vacuum suction, and closing the first electrovalve;
b. then starting the stirring device to stir the raw materials, simultaneously opening the second electrovalve, and spraying auxiliary liquid into the main tank body through the second straight pipe to bond the raw materials;
c. then the first motor drives the cutting piece to rotate through the first rotating shaft, the bonded raw materials are cut off, and particles are formed under the coordination of continuous overturning and cutting;
and finally, the telescopic cylinder drives the sealing plug to be opened, so that the formed particles are discharged along the discharge pipe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011041621.6A CN112190473A (en) | 2020-09-28 | 2020-09-28 | Wet granulation device for chiral drug preparation and use method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011041621.6A CN112190473A (en) | 2020-09-28 | 2020-09-28 | Wet granulation device for chiral drug preparation and use method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112190473A true CN112190473A (en) | 2021-01-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011041621.6A Withdrawn CN112190473A (en) | 2020-09-28 | 2020-09-28 | Wet granulation device for chiral drug preparation and use method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112190473A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115814700A (en) * | 2022-12-16 | 2023-03-21 | 南京泽朗生物科技有限公司 | Fruit and vegetable powder spray granulation device |
-
2020
- 2020-09-28 CN CN202011041621.6A patent/CN112190473A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115814700A (en) * | 2022-12-16 | 2023-03-21 | 南京泽朗生物科技有限公司 | Fruit and vegetable powder spray granulation device |
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Application publication date: 20210108 |