CN1121881C - Magnetogyric electrochemical apparatus for treating tumor - Google Patents

Magnetogyric electrochemical apparatus for treating tumor Download PDF

Info

Publication number
CN1121881C
CN1121881C CN 98115303 CN98115303A CN1121881C CN 1121881 C CN1121881 C CN 1121881C CN 98115303 CN98115303 CN 98115303 CN 98115303 A CN98115303 A CN 98115303A CN 1121881 C CN1121881 C CN 1121881C
Authority
CN
China
Prior art keywords
power supply
power source
iii
magnetic field
electrification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN 98115303
Other languages
Chinese (zh)
Other versions
CN1238999A (en
Inventor
陈国璋
陈惠晓
余祖明
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zhejiang University ZJU
Original Assignee
Zhejiang Medical University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhejiang Medical University filed Critical Zhejiang Medical University
Priority to CN 98115303 priority Critical patent/CN1121881C/en
Publication of CN1238999A publication Critical patent/CN1238999A/en
Application granted granted Critical
Publication of CN1121881C publication Critical patent/CN1121881C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Magnetic Treatment Devices (AREA)

Abstract

The present invention relates to an electrochemistry therapeutic device for treating a tumour, which belongs to a medical appliance. The present invention is characterized in that a direct current magnetic field excitation power source, an alternating magnetic field excitation power source are connected with an electromagnet coil sheathed on an electromagnet iron core; an electric chemotherapeutic power source, a high-voltage pulse power source and an alternating power source are connected with at least two electrodes and a central electrode; a radio-frequency power source is connected with the central electrode. Because a direct current magnetic field, an alternate current magnetic field, a pulse electric field and microwaves are added to act on a tumour, the biological chemistry molecules of a tumour tissue move in a convolution mode in the whole tumour tissue to overcome columnar lethal effect and enhance curative effect.

Description

Magnetogyric electrochemical apparatus for treating tumor
The present invention relates to treat the used electrochemical therapeutic therapeutic apparatus of tumor and belong to medical apparatus and instruments.
The unidirectional current chemotherapy is that the radiological medicine expert of Sweden starts, it is to insert a pair of or one group of electrode on tumor tissues, pass to DC current, thereby a series of bio electrochemistry such as tumor tissues generation electrolysis around the electrode, electrophoresis, electric osmose changes, and makes it downright bad and reach the effect that presses down tumor.Normally used device is made up of panel, power supply, electrode needle, but preset voltage, electric current, treatment time.This therapy has little, safe, simple, the maneuverable advantage of wound.But because charged particle is in the swimming of electrode catch cropping straight line, form fixed passage betwixt, therapeutant uniform distribution in time in tumor tissues.Cause area for treatment only be centered around pin around form the column lethal effect, influence therapeutic effect.
The objective of the invention is to provide a kind of magnetogyric electrochemical apparatus for treating tumor that in being subjected to curing oncoma, increases magnetic field, high-pressure pulse electric and microwave.
Task of the present invention is accomplished by following technical scheme: D.C. magnetic field field power supply, alternating magnetic field field power supply are received on the electromagnet coil, and electromagnet coil is enclosed within on the electromagnet core.The utmost point that electrification is treated power supply, high-voltage pulse power source links to each other with central electrode with radio frequency (microwave) power supply through connecting line, and another utmost point links to each other with plural at least peripheral electrode.
The present invention improves existing electrochemical therapeutical instrument, has increased direct current and AC magnetic field, impulse electric field and microwave to function of tumor.When using D.C. magnetic field, adopt the unidirectional current chemotherapy.The central electrode pin that inserts tumor tissues this moment is negative pole (an also positive level), the peripheral electrode pin that inserts tumor tissues is anodal (or negative pole), when magnetic direction and direction of an electric field are vertical mutually, making in the tumor tissues at the ion of swimming between electrode and other charged particle is the axle center with the central electrode under the effect at Lorentz force again simultaneously, does circumnutation in whole tumor tissues.Charged particle has attracted water and other polar molecule of varying number around it, and has driven the electrochemotherapy material and do circumnutation together, makes the therapeutical effect can be synchronous in time as much as possible, spatially carries out equably.Thereby overcome the weak point of electrochemical treatment.Can strengthen the magnetic circumnutation by alternating magnetic field and interelectrode alternating electric field that certain requirement alternately adds.The particle of doing circumnutation in tumor tissues is distributed in respectively in intercellular fluid and the intracellular fluid, and the former will pass intercellular slit, and the latter also will pass cell membrane, thereby produces the resistance of motion in various degree.According to the Lorentz force law, electric-field strength, when charged grain power movement velocity is big, Lorentz force is just big under same magnetic field intensity, can overcome certain resistance.But during electric-field strength, cell reaction in the tumor tissues is accelerated, and product (tumor cell kill and wound material) increases, and can not in time borrow circumnutation uniform distribution in tumor tissues.For improving this situation, electric field and magnetic field synchronously change over alternating field frequently, make the direction of circumnutation constant, and cell reaction slows down or stop to carry out, and are the accumulation of scalable electrode reaction product around electrode needle like this.This can not only strengthen the space-time regulating action of treatment, and can improve the utilization rate of therapeutant and the effectiveness of treatment.Impulse electric field of Jia Ruing and microwave electromagnetic field also all further heighten the effect of a treatment on request.
Fig. 1 is a principle of the invention sketch map.
Fig. 2 is an embodiment of the invention structural representation.
Below in conjunction with accompanying drawing the present invention is described in further detail.
Referring to Fig. 1, Fig. 2, the present invention mainly is made up of four parts, promptly form by circle round part II, treatment part III and therapeutic bed IV of power pack I, magnetic, power pack I and the magnetic part II that circles round is connected, treatment part III is connected with therapeutic bed IV, wherein power pack I comprises dc excitation power 1, AC excitation electric current 2, panel 13, power supply box 15, gang switch 16, dc excitation power 1, AC excitation electric current 2, gang switch 16 are installed in the power supply box 15, and panel 13 links to each other with power supply box 15; The magnetic part II that circles round comprises electromagnetic core 6, magnetic pole head 7, electromagnet coil 8, yoke 14, magnetic pole head 7 passes through the magnetic force adhesive with electromagnetic core 6, utmost point magnetic head (7) is one group and can is selected to change according to the tumor shape difference, the magnetic pole head that geometry is different, electromagnet coil 8 is enclosed within on the electromagnetic core 6, insert in the yoke 14, the two can be threaded to realize changing both relative positions, dc excitation power 1 is connected with electromagnet coil 8 by gang switch 16 with AC excitation electric current 2, by gang switch 16 controls, by selecting with in direct current or the AC excitation electric current access electromagnet coil 8, in yoke 14, produce magnetic induction, import in the air gap by electromagnetic core 6 and magnetic pole head 7, treatment part III can be made up of treatment power supply III-1 and electrode III-2, wherein treat power supply III-1 and comprise radio frequency (microwave) power supply 3, electrification is treated power supply 4, high-voltage pulse power source 5, electrode III-2 comprises central electrode pin 9, peripheral electrode pin 10 more than two, 11 and coaxial transmission line 17, the top of this coaxial transmission line 17 links to each other with radio frequency (microwave) power supply 3, the center conductor of terminal links to each other with central electrode pin 9, the utmost point that electrification is treated power supply 4 and high-voltage pulse power source 5 links to each other with the center conductor of coaxial transmission line 17, another utmost point links to each other with the outer conductor of coaxial transmission line 17, outer conductor terminal idiostaticly with a plurality of peripheral electrode pins 10,11 ... link to each other, dc excitation power 1, AC excitation electric current 2 is treated between the power supply 4 with electrification and is linked to each other by gang switch 16, and alternating source acts on electrode simultaneously when using alternating magnetic field with assurance; Therapeutic bed IV comprises a body 12, and is removable, settles radio frequency (microwave) power supply 3, electrification to treat power supply 4 and high-voltage pulse power source 5 under its bed board, and electrification is treated power supply (4) and linked to each other with gang switch (16).
Magnetic field is produced by the electric current electromagnet coil of flowing through, there are D.C. magnetic field and AC magnetic field in magnetic field, can be respectively by dc excitation power (1) and AC excitation electric current (2), control by gang switch (16), when gang switch (16) was connected dc excitation power (1), it was direct current that electrification is treated electric current, when connecting the AC excitation current source, electrification is treated electric current and is then disconnected direct current, to insert electrode with the frequency alternating current synchronously.In order to make the curative effect increase can be respectively at loading high electric field pulse on the electrode needle or/and radio frequency (microwave), radio frequency (microwave) transfers to electrode needle by coaxial line, this moment, the center conductor of coaxial line connect the central electrode pin, and the peripheral electrode pin more than two and the outer conductor of coaxial line join and form microwave radiometer.
During treatment, by guide pin electrode is inserted the pre-determined position of tumor tissues, patient is sent between the two magnetic pole heads 7, make tumor tissues be exposed to the magnetic field air gap that two magnetic pole heads are formed promptly to treat in the space by adjusting therapeutic bed, two electromagnet core 6 relative positions.Connect field power supply magnetic field is transferred to desirable strength, connect electrification treatment electricity simultaneously and go into impulse electric field and/or microwave electromagnetic field, with intensive treatment.Be antenna with the electrode this moment, not only produced DC current but also produced the microwave electromagnetic waves of certain intensity, and to predetermined treatment time, treatment is finished.When using AC magnetism to circle round electrochemotherapy, can connect ac excitation power supply 2 by gang switch 16 controls, also control electrification is treated power supply 4 simultaneously, and alternating current power supply and electrode are connected, synchronously on electrode, add (with frequently) AC field, disconnect unidirectional current chemotherapy source.

Claims (3)

1. kind magnetogyric electrochemical apparatus for treating tumor, comprise power pack and electrode, it is characterized in that: also be provided with magnetic circle round the part (II), treatment part (III) and therapeutic bed (IV), magnetic circles round partly, and (II) comprises electromagnetic core (6), magnetic pole head (7), electromagnet coil (8) and yoke (14), magnetic pole head (7) passes through the magnetic force adhesive with electromagnetic core (6), electromagnet coil (8) is enclosed within on the electromagnetic core (6), insert in the yoke (14), dc excitation power (1) is connected with electromagnet coil (8) by gang switch (16) with AC excitation electric current (2), treatment part (III) can be made up of treatment power supply (III-1) and electrode (III-2), wherein treat power supply (III-1) and comprise radio frequency (microwave) power supply (3), electrification is treated power supply (4), high-voltage pulse power source (5), electrode (III-2) comprises central electrode pin (9), peripheral electrode pin (10) more than two, (11) and coaxial transmission line (17), the top of coaxial transmission line (17) is connected with radio frequency (microwave) power supply (3), the center conductor of terminal links to each other with central electrode pin (9), the utmost point that electrification is treated power supply (4) and high-voltage pulse power source (5) links to each other with the center conductor of coaxial transmission line (17), another utmost point links to each other with the outer conductor of coaxial transmission line (17), outer conductor terminal idiostaticly with peripheral electrode pin (10) more than two, (11) link to each other, electrification is treated power supply (4) and is linked to each other with gang switch (16).
2, according to right 1 described magnetogyric electrochemical apparatus for treating tumor, it is characterized in that: is one group of magnetic pole head that geometry is different with electromagnetic core (6) with the magnetic pole head (7) of magnetic force adhesive.
3, magnetogyric electrochemical apparatus for treating tumor according to claim 1 is characterized in that: therapeutic bed IV comprises a body (12), settles radio frequency (microwave) power supply (3), electrification to treat power supply (4) and high-voltage pulse power source (5) under its bed board.
CN 98115303 1998-06-15 1998-06-15 Magnetogyric electrochemical apparatus for treating tumor Expired - Fee Related CN1121881C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN 98115303 CN1121881C (en) 1998-06-15 1998-06-15 Magnetogyric electrochemical apparatus for treating tumor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN 98115303 CN1121881C (en) 1998-06-15 1998-06-15 Magnetogyric electrochemical apparatus for treating tumor

Publications (2)

Publication Number Publication Date
CN1238999A CN1238999A (en) 1999-12-22
CN1121881C true CN1121881C (en) 2003-09-24

Family

ID=5224489

Family Applications (1)

Application Number Title Priority Date Filing Date
CN 98115303 Expired - Fee Related CN1121881C (en) 1998-06-15 1998-06-15 Magnetogyric electrochemical apparatus for treating tumor

Country Status (1)

Country Link
CN (1) CN1121881C (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005120171A2 (en) * 2004-06-07 2005-12-22 Rajah Vijay Kumar Apparatus for tissue regeneration or degeneration in humans
CN106621050A (en) * 2017-02-07 2017-05-10 浙江大学 Power frequency electromagnetic field generating device having tumor inhibiting effect and loading method

Also Published As

Publication number Publication date
CN1238999A (en) 1999-12-22

Similar Documents

Publication Publication Date Title
US4454883A (en) Electrotherapeutic apparatus
EP1916013B1 (en) Hyperthermia device for the selective treatment and monitoring of surface tissue
KR100497500B1 (en) A stimulation coil using magnetic mirror and use thereof
US4838850A (en) Electromedical treatment apparatus
US7335156B2 (en) Digital electromagnetic pulse generator
EP0208338A2 (en) Induction heating apparatus
CN106139419B (en) Rotating frame for treating tumors
US20040115784A1 (en) Apparatus and method for streaming electroporation
EP0966988A1 (en) Apparatus and method for interfering with pathological cells survival
KR100484618B1 (en) Apparatus for stimulating nerves
US20230149708A1 (en) Tumor treating fields (ttf) for cancer treatment
CN104623811B (en) The intelligent magnetic mattress of automatic adjusument magnetic intensity
CN1121881C (en) Magnetogyric electrochemical apparatus for treating tumor
Yao et al. Gene transfer and drug delivery with electric pulse generators
IL303111A (en) System and methods for treating cancer cells with alternating polarity magnetic fields
US9421370B2 (en) System for diagnosing and treatment of pancreas, other tissues and organs and other medical conditions
CN111250016B (en) Liquid plasma device for treating tumor and skin disease
CN106823133A (en) Electrical transcranial stimulation and trans-skull magnetic stimulating device based on electrode
EP0058564A1 (en) Improvements in or relating to electrotherapeutic apparatus
CN116328193A (en) Multi-target-point accurate adjustable magnetic stimulation method and system based on time coherence
KR20100078748A (en) Focusing type needle using variable electromagnetic field
JP2022515597A (en) Methods and systems for applying a pulsed electric field with high uniformity using a magnetic core
Ali et al. Solid Ehrlich tumor growth treatment by magnetic waves
CN106399090A (en) Electromagnetic environment generator for microorganism culture tests and experimental method
KR20240056945A (en) Pulsed electro-magnetic field generator

Legal Events

Date Code Title Description
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C06 Publication
PB01 Publication
C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1043894

Country of ref document: HK

C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee