CN112169066B - Continuous slow-release drug administration indwelling tube with controller - Google Patents

Continuous slow-release drug administration indwelling tube with controller Download PDF

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Publication number
CN112169066B
CN112169066B CN202011183332.XA CN202011183332A CN112169066B CN 112169066 B CN112169066 B CN 112169066B CN 202011183332 A CN202011183332 A CN 202011183332A CN 112169066 B CN112169066 B CN 112169066B
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China
Prior art keywords
tube
controller
drug
storage bag
puncture
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CN202011183332.XA
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CN112169066A (en
Inventor
夏敏
王胜
谭斌
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Anhui Provincial Hospital First Affiliated Hospital Of Ustc
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Anhui Provincial Hospital First Affiliated Hospital Of Ustc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16877—Adjusting flow; Devices for setting a flow rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/18—General characteristics of the apparatus with alarm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

The invention provides a continuous slow-release drug delivery indwelling tube with a controller, which comprises a slow-release tube body with a hollow tube cavity, a drug injection tube, a drug storage bag and the controller, wherein the slow-release tube body is provided with a first tube wall and a second tube wall positioned outside the first tube wall, the second tube wall is a slow-release film, the slow-release cavity is formed between the first tube wall and the second tube wall and is communicated with the drug storage bag through the drug injection tube, the drug storage bag is positioned in the controller, and the controller is configured to adjust the drug storage bag to force out the liquid medicine in the drug storage bag at a preset drug injection pressure or drug injection speed, and the liquid medicine enters the drug injection tube and seeps out to the outside of the drug storage bag through the second tube wall. The continuous slow-release drug administration indwelling tube with the controller provided by the invention avoids repeated puncture of patients needing multiple drug administration, does not need multipoint puncture of patients with wide drug administration range, reduces pain of patients in the medical process, and improves the medical experience of the patients.

Description

Continuous slow-release drug administration indwelling tube with controller
Technical Field
The invention belongs to the technical field of medical appliances, and particularly relates to a continuous slow-release drug delivery indwelling tube with a controller.
Background
For many patients with sports injuries, a local nerve blocking method is often needed to relieve pain and eliminate inflammation, and for some patients with substantial tumors, tumor cells can be killed by tumor injection. However, the prior art can only be used for single administration, and patients needing multiple administrations have to puncture repeatedly, which clearly increases the pain of the patients; and when in administration, the medicine can only flow out from the outlet of the administration tube in a concentrated way, and the medicine is often gathered at the outlet and cannot spread to a far enough area, so that for some patients needing wide administration range, the medicine has to be subjected to multipoint puncture administration, and for the patients adopting continuous administration treatment of the percutaneous puncture area (such as pain relieving, chemotherapy and the like), no good way can be provided for long-time and uniform local administration, and the invention is based on the proposal.
Disclosure of Invention
Therefore, the technical problem to be solved by the invention is to provide the continuous slow-release drug administration indwelling tube with the controller, so that repeated puncture of a patient needing multiple drug administration is avoided, multipoint puncture of the patient with a wide drug administration range is not needed, pain in the medical process of the patient is reduced, and the medical experience of the patient is improved.
In order to solve the problems, the invention provides a continuous slow release drug delivery indwelling tube with a controller, which comprises a slow release tube body with a hollow tube cavity, a drug injection tube, a drug storage bag and the controller, wherein the slow release tube body is provided with a first tube wall and a second tube wall positioned outside the first tube wall, the second tube wall is a slow release membrane, the slow release cavity is formed between the first tube wall and the second tube wall, the slow release cavity is communicated with the drug storage bag through the drug injection tube, the drug storage bag is positioned in the controller, and the controller is configured to adjust the drug storage bag to force out the drug liquid in the drug storage bag at a preset drug injection pressure or drug injection speed, and the drug liquid enters the drug injection tube and seeps to the outer side of the drug storage bag through the second tube wall.
Preferably, the slow release film is made of medical hydrophilic and hydrophobic nano composite materials.
Preferably, the medical hydrophilic and hydrophobic nanocomposite comprises one of fluorine-containing polymer and polyurethane.
Preferably, the continuous sustained release drug delivery indwelling catheter with controller further comprises a puncture core capable of passing through the hollow lumen.
Preferably, the first end of the plunger has a syringe interface.
Preferably, the medicine injection tube is communicated with the medicine storage bag through a connecting tube, and the connecting tube is a flexible tube.
Preferably, the drug injection tube and the slow release tube body are connected into a whole.
Preferably, a display screen is arranged on the controller; and/or the controller is provided with an adjusting button.
Preferably, the controller is also internally provided with an induction element, the induction element is used for detecting the inner cavity pressure of the medicine storage bag, and the obtained inner cavity pressure signal is transmitted and displayed on the display after being processed by a core operation element in the controller; and/or, the obtained inner cavity pressure signal is calculated by a core calculation element in the controller to obtain the residual medicine quantity in the medicine storage bag, and the obtained residual medicine quantity is transmitted and displayed on the display.
Preferably, the controller further comprises an alarm device, and the alarm device is used for sending an alarm signal when the inner cavity pressure of the medicine storage bag acquired by the sensing element exceeds a preset interval.
According to the continuous slow-release drug delivery indwelling tube with the controller, due to the design of the drug storage bag and the slow-release cavity, medical staff can achieve the purposes of multi-point puncture and repeated puncture in the prior art only by puncturing once, liquid medicine in the drug storage bag, the drug injection tube and the slow-release cavity can slowly permeate and seep to indwelling target tissues of a patient through the second tube wall, the tube length of the slow-release cavity can cover a larger drug delivery area, multi-point puncture and repeated puncture of a patient with a wide drug delivery range are not needed, pain of the patient in a medical process is reduced, medical experience of the patient is improved, and in addition, the controller is used for achieving adjustment control of drug injection pressure or drug injection speed of the liquid medicine in the drug storage bag, so that drug delivery quantity can be accurately controlled.
Drawings
Fig. 1 is a schematic structural view of a continuous sustained release administration indwelling catheter with a controller according to an embodiment of the present invention.
The reference numerals are expressed as:
1. a slow-release tube body; 11. a first tube wall; 12. a second tube wall; 13. a slow release cavity; 2. a drug injection tube; 21. a connecting pipe; 3. a drug storage bag; 4. puncturing the inner core; 41. a syringe interface; 5. a controller; 51. a display screen; 52. an adjusting button.
Detailed Description
Referring to fig. 1, according to an embodiment of the present invention, there is provided a continuous sustained release drug delivery indwelling tube having a controller, including a sustained release tube body 1 having a hollow tube cavity, a drug injection tube 2, and a drug storage bag 3, the sustained release tube body 1 having a first tube wall 11 and a second tube wall 12 located outside the first tube wall 11, wherein the second tube wall 12 is a sustained release membrane, a sustained release cavity 13 is formed between the first tube wall 11 and the second tube wall 12, the sustained release cavity 13 is communicated with the drug storage bag 3 through the drug injection tube 2, the drug storage bag 3 is located in the controller 5, the controller 5 is configured to be able to adjust the drug storage bag 3 to force out a drug solution in the drug storage bag 3 at a preset drug injection pressure or drug injection speed, the drug solution enters the drug injection tube 2 and oozes to the outside thereof via the second tube wall 12. According to the technical scheme, through the design of the medicine storage bag 3 and the slow release cavity 13, medical staff can realize the purposes of multi-point puncture and repeated puncture in the prior art by only puncturing once, the medicine liquid in the medicine storage bag 3, the medicine injection pipe 2 and the slow release cavity 13 can slowly permeate and seep to the detained target tissue of a patient through the second pipe wall 12, the pipe length of the slow release cavity 13 can cover a larger medicine administration area, multi-point puncture and repeated puncture of a patient with a wide medicine administration range are not needed, so that pain in the medical process of the patient is reduced, the medical experience of the patient is improved, and in addition, the regulation and control of the medicine injection pressure or the medicine injection speed of the medicine liquid in the medicine storage bag 3 are realized through the controller 5 in the technical scheme, so that the medicine administration amount can be accurately controlled. It can be understood that the medicine storage bag 3 is provided with a medicine injection port so as to realize the medicine liquid supplement of the medicine storage bag 3. The first pipe wall 11 is made of an impermeable film, so that the liquid medicine is prevented from penetrating into the hollow cavity of the slow-release pipe body 1.
Preferably, the medicine storage bag 3 is made of elastic material, specifically, for example, one of silica gel, rubber, latex or nylon, wherein the wall thickness of the silica gel is 0.2-0.4mm, the shore softness is 30, and the medicine storage bag can be made by injection molding or bonding process, has good elasticity, stable product performance and transparent color, and is beneficial for operators to observe the condition of medicine liquid in the bag; the wall thickness of the formable rubber is 0.5-0.8mm, the Shore softness is 40, the formable rubber can be manufactured by adopting an injection molding or bonding process, the formable rubber has general elasticity, rough appearance and high hardness, is white, and can not observe the condition of liquid medicine in the bag; the latex can be formed with the wall thickness of 0.2-1mm and the Shore softness of 20-30, can be manufactured by adopting an injection molding or bonding process, has moderate elasticity, is not fine and smooth in appearance, is semitransparent, and has poor shaping effect; the nylon formable wall thickness is 0.2-0.6mm, can be manufactured by adopting an adhesion process, has poor elasticity and is semitransparent, so that the medicine storage bag 3 is preferably manufactured by adopting silica gel.
As a specific embodiment, preferably, the controller 5 is provided with a display screen 51 for displaying the current administration speed or administration pressure, so as to facilitate the medical staff to clearly administer the medicine during the infusion process; meanwhile, the controller 5 is provided with an adjusting knob 52, and the adjusting knob 52 is used for adjusting the administration speed or the administration pressure, for example, increasing the administration speed or the administration pressure or decreasing the administration speed or the administration pressure. Further, an induction element is further disposed in the controller 5, and is configured to detect the pressure of the inner cavity of the drug storage bag 3, and the obtained pressure signal of the inner cavity is processed by a core operation element in the controller 3, and then transmitted and displayed on the display 51; and/or, the obtained inner cavity pressure signal is calculated by a core calculation element in the controller 3 to obtain the residual medicine in the medicine storage bag 3, and the obtained residual medicine is transmitted and displayed on the display 51.
As a better embodiment, the controller 5 further includes an alarm device, configured to send an alarm signal when the cavity pressure of the drug storage bag 3 obtained by the sensing element exceeds a preset interval (i.e. when the cavity pressure is lower than a certain low pressure preset threshold or higher than a certain high pressure preset threshold), where the alarm signal includes a manner of flashing an indicator light, a beeping sound or a text prompt, so as to prompt a medical staff to adjust the drug delivery pressure in time.
The slow-release membrane is preferably made of medical hydrophilic and hydrophobic nano composite materials, specifically, the medical hydrophilic and hydrophobic nano composite materials comprise one of fluorine-containing high polymers and polyurethane, and the pore diameter of a permeation hole on the slow-release membrane is 1-100nm.
Further, the continuous sustained release administration indwelling catheter with the controller further comprises a puncture inner core 4, wherein the puncture inner core 4 can pass through the hollow lumen, namely, the puncture inner core 4 can be pulled out of the hollow lumen or inserted into the hollow lumen, so that the percutaneous puncture process of the indwelling catheter is facilitated. Preferably, the injection tube 2 is integrally connected with the sustained release tube body 1 to prevent leakage of the liquid medicine at the joint. The interface between the drug injection tube 2 and the slow release tube body 1 should be positioned in the target indwelling tissue when the indwelling tube is applied so as to prevent the drug solution from leaking out to the outer side of the skin of the human body when the slow release drug is applied.
The inner core 4 is made of a hard medical material, and has a syringe interface 41 at a first end (i.e., an end located outside the human body) to connect a syringe to inject the medical fluid directly through the inner core.
Preferably, the medicine injection tube 2 is communicated with the medicine storage bag 3 through a connecting tube 21, the connecting tube 21 is a flexible tube, and the connecting tube 21 has flexibility, so that the medicine injection tube can facilitate the selection of the medicine injection angle of medical staff when medicine is injected into the medicine storage bag 3.
As a more preferable embodiment, the outer periphery of the slow release tube body 1 may be optionally sleeved with a slow release administration positioning film sleeve (not shown in the figure), the slow release administration positioning film sleeve is provided with a through hole, the slow release administration positioning film sleeve outside the through hole can prevent the liquid medicine in the slow release tube body 1 from exuding, and the through hole can allow the liquid medicine in the slow release tube body 1 to exude, so that the liquid medicine in the slow release tube body 1 can be positioned, so that the slow release tube body is suitable for the situation that some punctiform lesions need continuous administration.
It will be readily appreciated by those skilled in the art that the above advantageous ways can be freely combined and superimposed without conflict.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, and alternatives falling within the spirit and principles of the invention. The foregoing is merely a preferred embodiment of the present invention, and it should be noted that it will be apparent to those skilled in the art that modifications and variations can be made without departing from the technical principles of the present invention, and these modifications and variations should also be regarded as the scope of the invention.

Claims (10)

1. The continuous slow-release drug delivery indwelling tube with the controller is characterized by comprising a slow-release tube body (1) with a hollow tube cavity, a drug injection tube (2), a drug storage bag (3) and a controller (5), wherein the slow-release tube body (1) is provided with a first tube wall (11) and a second tube wall (12) positioned outside the first tube wall (11), the second tube wall (12) is a slow-release membrane, a slow-release cavity (13) is formed between the first tube wall (11) and the second tube wall (12), the slow-release cavity (13) is communicated with the drug storage bag (3) through the drug injection tube (2), the drug storage bag (3) is positioned in the controller (5), and an induction element is arranged in the controller (5) and is used for detecting the inner cavity pressure of the drug storage bag (3); the controller (5) is configured to adjust the medicine storage bag (3) to force the medicine liquid in the medicine storage bag (3) out at a preset medicine injection pressure or medicine injection speed, and the medicine liquid enters the medicine injection tube (2) and seeps out to the outer side of the medicine injection tube through the second tube wall (12); the medicine storage bag (3) is made of elastic materials.
2. The continuous sustained release drug delivery indwelling catheter for puncture with a controller according to claim 1, wherein said sustained release membrane is made of a hydrophilic and hydrophobic nanocomposite for medical use.
3. The continuous sustained release drug delivery indwelling catheter for puncture with controller according to claim 2, wherein said hydrophilic and hydrophobic nanocomposite for medical use comprises one of fluorine-containing polymer and polyurethane.
4. The continuous sustained release drug delivery indwelling catheter for puncture with controller according to claim 1, further comprising a puncture core (4), said puncture core (4) being capable of passing in said hollow lumen.
5. The continuous sustained release drug delivery indwelling catheter for puncture with controller according to claim 4, wherein the first end of the puncture core (4) has a syringe interface (41).
6. The continuous sustained release drug delivery indwelling catheter for puncture with controller according to claim 1, wherein said drug injection tube (2) is in communication with said drug storage bag (3) through a connecting tube (21), said connecting tube (21) being a flexible tube.
7. The continuous sustained release drug delivery indwelling catheter for puncture with a controller according to claim 6, wherein said drug injection tube (2) is integrally connected with said sustained release catheter body (1).
8. Continuous sustained release drug delivery indwelling catheter with controller for puncture according to any of claims 1 to 7, wherein a display screen (51) is provided on said controller (5); and/or the controller (5) is provided with an adjusting button (52).
9. The continuous sustained release drug delivery indwelling catheter for puncture with a controller according to claim 8, wherein the lumen pressure signal acquired by the controller (5) is transmitted and displayed on the display screen (51) after being processed by a core operation element inside the controller (5); and/or, the obtained inner cavity pressure signal is calculated by a core calculation element in the controller (5) to obtain the residual medicine amount in the medicine storage bag (3), and the obtained residual medicine amount is transmitted and displayed on the display screen (51).
10. The continuous sustained release drug delivery indwelling catheter for puncture with controller according to claim 9, wherein said controller (5) further comprises alarm means for giving an alarm signal when the internal cavity pressure of said drug storage balloon (3) obtained by said sensing element exceeds a preset interval.
CN202011183332.XA 2020-10-29 2020-10-29 Continuous slow-release drug administration indwelling tube with controller Active CN112169066B (en)

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CN112915315B (en) * 2021-03-19 2022-07-19 荆文斌 Anti-extravasation chemotherapy administration device for medical oncology

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CN110151290A (en) * 2018-02-12 2019-08-23 香港科能有限公司 The implantation material of releasable medicaments and manufacture and application method

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CN109173017A (en) * 2018-09-11 2019-01-11 苏州科技城医院 The pleural effusions and ascites puncture drainage tube of anti-blocking anticreep antiseepage

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