CN112168701B - Soft capsule manufacturing process and manufacturing system thereof - Google Patents
Soft capsule manufacturing process and manufacturing system thereof Download PDFInfo
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- CN112168701B CN112168701B CN202011088521.9A CN202011088521A CN112168701B CN 112168701 B CN112168701 B CN 112168701B CN 202011088521 A CN202011088521 A CN 202011088521A CN 112168701 B CN112168701 B CN 112168701B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B26—HAND CUTTING TOOLS; CUTTING; SEVERING
- B26F—PERFORATING; PUNCHING; CUTTING-OUT; STAMPING-OUT; SEVERING BY MEANS OTHER THAN CUTTING
- B26F3/00—Severing by means other than cutting; Apparatus therefor
- B26F3/06—Severing by using heat
- B26F3/08—Severing by using heat with heated members
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Abstract
The invention discloses a soft capsule manufacturing process and a manufacturing system thereof, wherein the manufacturing process comprises the following steps: the method comprises the following steps: (1) sending the glue solution in the glue solution barrel into a glue solution box, and adding the liquid medicine into a liquid medicine box; (2) extruding the glue solution in the heat-preservation glue solution box through an outer ring discharge hole of an annular extrusion nest to form glue solution, and cooling and solidifying to form a rubber sheet; (3) cutting the lower end of the adhesive rubber by adopting a spiral hot cutting device, and simultaneously injecting the liquid medicine in the liquid medicine tank into the rubber through an annular extrusion nested inner ring discharge port; (4) cutting the upper end of the adhesive rubber sheet by using a spiral hot cutting device again, and conveying the formed rubber pills onto a conveying belt to the next working section; (5) repeating the steps to realize the continuous production of the soft capsule. The soft capsule manufacturing process and the manufacturing system thereof of the invention manufacture the soft capsule by hot cutting the upper and lower sealing of the rubber sheet and cutting and separating, and can efficiently produce even in the case of soft capsule dosage forms with thicker liquid medicine.
Description
Technical Field
The invention relates to the technical field of soft capsule forming, in particular to a soft capsule manufacturing process and a soft capsule manufacturing system.
Background
The soft capsule is a novel medicine preparation developed after preparations such as tablets, hard capsules, pills, oral liquid and the like. The soft capsule can quantitatively press and inject functional substance functional oil or suspension of oily and powdery functional substances into an adhesive film to form sealed capsules with different sizes and shapes, and has excellent light and oxygen isolating function and good visual effect. It is popular with consumers because of its advantages of covering bad smell, keeping stability of oily substance, convenient use and carrying.
The soft capsule has been rapidly developed in China since the last 80 th century, the variety and the yield of the soft capsule are continuously increased along with the continuous updating of production equipment, and the development of the traditional Chinese medicine soft capsule preparation is also hot. The existing soft capsule manufacturing process is mainly a dropping method and a rotary die pressing method, and the frequent problems of injector blockage and the like can occur when liquid medicine in a part of varieties of prescriptions is thicker or equipment can not be normally produced directly, so that the production efficiency and the variety expansion of soft capsule products are seriously influenced.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: aiming at the defects in the prior art, the novel soft capsule manufacturing process and the manufacturing system thereof are provided, wherein the liquid medicine is injected into the rubber sheet through the feeding pipe, and the soft capsule is formed by hot cutting, upper sealing, lower sealing, cutting and separating, so that the efficient production can be realized even when the soft capsule with thick liquid medicine is encountered.
In order to achieve the purpose, the invention adopts the following technical scheme:
the first aspect of the present invention provides a process for manufacturing soft capsules, comprising the steps of:
(1) the glue solution in the glue solution barrel is pumped into a sealed glue solution tank through a glue delivery pipe, and the liquid medicine is added into a liquid medicine tank;
(2) extruding the glue solution in the heat-preservation glue solution box through an outer ring discharge hole of an annular extrusion nest to form glue solution, and cooling and solidifying to form a rubber sheet;
(3) cutting the lower end of the adhesive rubber by adopting a spiral hot cutting device, and simultaneously injecting the liquid medicine in the liquid medicine tank into the rubber through an annular extrusion nested inner ring discharge port;
(4) after the rubber sheet injected with the liquid medicine is extruded for a period of time, the upper end of the adhesive rubber sheet is cut and bonded by the spiral hot cutting device again, and the formed capsules fall on the conveying belt and are conveyed to the next working section;
(5) repeating the steps (2) to (4) to realize the continuous production of the soft capsules.
Further, in the soft capsule manufacturing process, in the step (1), the glue solution in the glue solution barrel is pumped to the glue solution tank by high-pressure gas or a delivery pump.
Further, in the soft capsule manufacturing process, in the step (2), the cooling adopts room temperature cooling, room temperature air cooling and/or cold air cooling.
Further, in the soft capsule manufacturing process, in the step (2), the thickness of the rubber is in direct proportion to the extrusion flow rate of the glue solution.
Further, in the soft capsule manufacturing process, in the step (3), the lower end of the rubber sheet is kept in a continuous extrusion state while injecting the liquid medicine after being cut and bonded.
Further, in the soft capsule manufacturing process, in the step (3), the liquid medicine is injected into the gelatin skin by means of high-pressure gas pressure or a delivery pump.
Further, in the soft capsule manufacturing process, in the step (4), the spiral thermal cutting device performs shear bonding on the lower end of the next rubber sheet while shear bonding the upper end of the rubber sheet.
In a second aspect of the present invention, there is provided a soft capsule manufacturing system comprising:
a liquid medicine box for providing liquid medicine for the system;
the glue solution box is used for providing glue solution for the system;
the annular extrusion nesting sleeve is provided with an outer annular extrusion pipe communicated with the glue liquid box and an inner annular extrusion pipe communicated with the liquid medicine box, and the outlet end of the inner annular extrusion pipe extends out of the outlet end of the outer annular extrusion pipe; and
and the spiral hot cutting device is correspondingly arranged at the outlet end of the annular extrusion nest and is used for carrying out hot cutting and bonding on the rubber before and after the liquid medicine is injected.
Further, in the soft capsule manufacturing system, the bottom of the liquid medicine tank is communicated with the inner ring extrusion pipes of the annular extrusion nests through liquid discharge pipes.
Further preferably, in the soft capsule manufacturing system, the liquid discharge pipe is composed of a liquid discharge main pipe and at least one liquid discharge branch pipe, the liquid discharge main pipe is provided with a liquid medicine main valve, and the liquid discharge branch pipe is provided with a liquid medicine branch valve.
More preferably, in the soft capsule manufacturing system, a first gas valve is arranged on the sealing cover at the top of the liquid medicine box, and the first gas valve is communicated with high-pressure gas.
Further, in the soft capsule manufacturing system, the liquid medicine tank is arranged in the liquid glue tank, and a heat insulation layer and a liquid glue jacket water interlayer are respectively arranged on the circumference of the liquid medicine tank and the liquid medicine tank.
Further, in the soft capsule manufacturing system, outlet ends of the outer ring extrusion pipe and the inner ring extrusion pipe are contracted inward in a sharp mouth shape.
Further, in the soft capsule manufacturing system, the soft capsule manufacturing method further includes:
the glue supply barrel is communicated with the glue liquid tank through a glue conveying pipe;
the glue supply barrel is provided with a glue barrel jacket water interlayer on the periphery, a sealing cover at the top is provided with a second gas valve, and the second gas valve is communicated with high-pressure gas.
Further, in the soft capsule manufacturing system, the soft capsule manufacturing method further includes:
a conveyor belt disposed below the helical thermal cutting apparatus;
wherein the conveyor belt is used for receiving the formed capsules and conveying the capsules to the next section.
By adopting the technical scheme, compared with the prior art, the invention has the following technical effects:
(1) compared with the existing dripping method and pressing method, the method has the advantages that the requirements on the physical properties, the loading amount and the like of the liquid medicine are very low due to the fact that the liquid medicine is filled through the feeding machine, so that soft capsules can be smoothly and efficiently manufactured by products with thick liquid medicine, the application range is wider, and the variety development of the soft capsules is promoted;
(2) compared with the existing pressing method, a large amount of net glue is generated, the recycling difficulty is higher, and a lot of production cost is increased; the method has the advantages that the amount of the waste gelatin generated by the method is small, the unit consumption of the gelatin is greatly reduced, and the method is economical and practical;
(3) compared with a dripping method, the production speed is relatively low, and the forming is poor when the loading is more than 200mg, by increasing the number of the annular nested discharge holes, the production speed and efficiency are improved, and the difficulty in product control is reduced;
(4) the method does not need to use extra materials such as cooling liquid, lubricating oil and the like, reduces the cost, obtains the semi-finished product of the soft capsule with clean surface, does not need extra steps such as washing the capsule and the like, does not have other material residues, and improves the production efficiency.
Drawings
FIG. 1 is a schematic view of the overall structure of a soft capsule manufacturing system according to the present invention;
FIG. 2 is a schematic view of a loop extrusion nest in a soft capsule manufacturing system of the present invention;
FIG. 3 is a schematic diagram of a side view of an annular extrusion nest in a soft capsule manufacturing system of the present invention;
FIG. 4 is a schematic top view of an annular extrusion nest in a soft capsule manufacturing system of the present invention;
wherein the reference symbols are:
10-a glue supply barrel, 11-a second gas valve, 12-a glue barrel jacket layer, 13-a glue conveying pipe, 14-a stop valve and 15-a flow regulating valve; 20-a liquid medicine box, 21-a first gas valve, 22-a heat insulation layer, 23-a liquid discharge pipe, 24-a liquid medicine main valve and 25-a liquid medicine branch valve; 30-glue solution tank, 31-glue solution jacket water interlayer; 40-annular extrusion nesting, 41-outer ring extrusion pipe and 42-inner ring extrusion pipe; 50-a spiral hot cutting device; 60-conveyor belt.
Detailed Description
The present invention will be described in detail and specifically with reference to the following examples to facilitate better understanding of the present invention, but the following examples do not limit the scope of the present invention.
In some embodiments, as shown in fig. 1, there is provided a soft capsule manufacturing process comprising the steps of:
(1) filling jacket water in a rubber barrel jacket layer 12 of a ground rubber supply barrel 10, connecting a power supply, preserving heat in a thermostatic water bath, filling rubber liquid in the rubber supply barrel 10, preserving heat for enough time, and then starting to glue a pill making machine;
(2) a discharge hole of the glue supply barrel 10 is connected with a feed hole of the glue solution tank 30 through a glue conveying pipe 13; connecting a compressed high-pressure gas pipeline to a second gas valve 11, pressing glue liquid into a glue liquid tank 30 through a glue conveying pipe 13, and keeping the temperature of the glue liquid tank 30 through a constant-temperature water bath of jacket water of a glue liquid jacket water interlayer 31;
(3) the glue solution in the glue solution tank 30 naturally flows out through a discharge hole of an outer ring extrusion pipe 41 on the annular extrusion nest 40 under the action of gravity or the action of the pressure difference between the inside and the outside of the glue solution tank 30, forms a glue skin after cooling and solidification, and then adopts a spiral hot cutting device 50 to cut and bond the lower end of the glue skin;
(4) adding a medicinal liquid into the medicinal liquid tank 20 while cutting the lower end of the adhesive sheet; the flow rate of the liquid medicine in each inner ring extrusion pipe 42 is controlled by the liquid medicine main valve 24 and the corresponding liquid medicine branch valves 25, and when part of the liquid medicine in the dosage form is thick and poor in fluidity, the first gas valve 21 is connected with high-pressure gas for pressurization, so that the liquid medicine can flow out smoothly;
(5) after the rubber sheet injected with the liquid medicine is extruded for a period of time, the upper end of the rubber sheet is hot-cut again by adopting the spiral hot-cutting device 50, the rubber sheet is spirally contracted, heated and bonded firstly, the liquid medicine enters the rubber pill, the hot-cut separation is carried out for the second time to seal the upper end of the rubber pill and separate the rubber pill from the tubular rubber sheet, and the rubber pill falls on the conveyor belt 60 and is conveyed to the next working section;
(6) repeating the steps 3-5 to realize the continuous production of the soft capsules.
In one embodiment, the glue solution in the glue solution barrel 10 can be pumped to the glue solution tank 30 by using a high-pressure gas, and the high-pressure gas can be high-pressure air or high-pressure nitrogen. If necessary, the glue in the glue tank 10 can be pumped to the glue tank 30 by a delivery pump. The glue solution in the glue solution tank 30 is subjected to heat preservation treatment, and the liquid medicine tank 20 is separated from the glue solution tank 30 by the heat insulation layer 22, so that the temperature is prevented from influencing liquid medicine in certain dosage forms.
In one embodiment, in step (3), the cooling is performed by room temperature cooling, room temperature air cooling and/or cold air cooling. If the room temperature is controlled in a proper range by an air conditioning system, the air is blown out by the Aryor cold air blower to solidify the glue solution into a hollow tubular rubber.
In one embodiment, in the step (3), the thickness of the rubber is proportional to the extrusion flow rate of the rubber solution. The extrusion flow rate of the glue solution can be controlled by adjusting the pressurizing pressure according to the required thickness of the rubber, and the larger the extrusion flow rate is, the thicker the prepared rubber is; the smaller the extrusion flow rate is, the thinner the rubber is prepared; in addition, the thickness of the rubber sheet is related to the size of the inner and outer ring extrusion ports of the annular extrusion nest 40.
In one embodiment, in the step (4), after the lower end of the rubber sheet is cut and bonded, the continuous extrusion state is kept while the liquid medicine is injected, and the production continuity of the soft capsule is kept.
In one embodiment, in step (5), the medical liquid is injected into the collagen sheath by means of high-pressure gas pressure or a delivery pump. If the liquid medicine of partial dosage forms is thick and has poor fluidity, the first gas valve 21 is connected with high-pressure nitrogen gas for pressurization, so that the liquid medicine can flow out smoothly.
In one embodiment, in the step (5), the spiral hot cutting device performs shear bonding on the lower end of the next rubber while shear bonding the upper end of the rubber. 1 capsule is separated by twice hot cutting, the liquid medicine is controlled to drip out according to the prescription amount each time through the inner ring extrusion pipe 42 through the liquid discharge pipe 23 while the lower end of the capsule is sealed by the first hot cutting, the upper end of the capsule is sealed and separated from the tubular rubber sheet by the second hot cutting after the liquid medicine enters the capsule, and the formed capsule after twice cutting and separation falls on the conveyor belt 60 to be conveyed to the next working section.
In other embodiments, as shown in fig. 1, 2, 3 and 4, there is also provided a soft capsule manufacturing system suitable for use in the above manufacturing process, comprising: a liquid medicine box 20 for providing liquid medicine for the system, the liquid medicine box 20 is connected with the glue supply barrel 10; the glue solution tank 30 is internally provided with the liquid medicine tank 20 and is used for providing glue solution for the system; a plurality of annular extrusion nests 40, wherein each annular extrusion nest 40 is provided with an outer annular extrusion pipe 41 communicated with the glue solution tank 30 and an inner annular extrusion pipe 42 communicated with the liquid medicine tank 20 which are coaxially arranged, and the outlet end of the inner annular extrusion pipe 42 extends out of the outlet end of the outer annular extrusion pipe 41; and a plurality of spiral hot cutting devices 50 which are correspondingly arranged at the position below the outlet end of the annular extrusion nest 40 and are used for carrying out hot cutting separation and bonding on the rubber before and after the liquid medicine is injected.
In one embodiment, as shown in fig. 1, the bottom of the drug solution tank 20 is communicated with the inner ring extrusion pipe 42 of each annular extrusion nest 40 through a liquid discharge pipe 23. The liquid discharge pipe 23 is composed of a liquid discharge main pipe and at least one liquid discharge branch pipe, a plurality of annular extrusion nesting sleeves 40 are connected, and the number of the annular extrusion nesting sleeves 40 can be determined according to actual requirements. The liquid main pipe is provided with a liquid main valve 24 for controlling the on-off of the liquid main pipe, and the liquid branch pipe is provided with a liquid branch valve 25 for controlling the on-off of the liquid in each annular extrusion nest 40.
In one embodiment, as shown in fig. 1, when the partial dosage form liquid medicine is thick and has poor flowability, a first gas valve 21 may be disposed on a sealing cover on the top of the liquid medicine box 20, the first gas valve 21 is connected to high pressure gas, that is, the liquid medicine is injected into the gelatin by high pressure gas pressure, and the first gas valve 21 is connected to high pressure nitrogen gas for pressurization, so that the liquid medicine can flow out smoothly. Further, a delivery pump may be provided in the discharge pipe 25 as necessary, and the chemical in the chemical tank 20 may be injected into the gel by a fixed amount using the delivery pump.
In one embodiment, as shown in fig. 1, the liquid medicine box 20 is disposed in the liquid glue box 30, and the liquid medicine box 20 and the liquid medicine box 30 are respectively provided with a heat insulation layer 22 and a liquid glue jacket water interlayer 31 on the peripheries thereof.
In one embodiment, as shown in fig. 1, the outlet ends of the outer ring extrusion tube 41 and the inner ring extrusion tube 42 are shrunk inwards to form a sharp mouth shape, and the outer ring extrusion tube 41 and the inner ring extrusion tube 42 with different opening sizes can be selected according to the required rubber thickness.
In one embodiment, as shown in FIGS. 3 and 4, the helical hot cutting apparatus 50 may be a commercially available medical bolt cutter. In addition, as an alternative, the spiral hot cutting device 50 can be replaced by a heating rod hot cutting device, and the formed capsule is changed into an oblate sphere from an ellipsoid/tube type.
In one embodiment, as shown in fig. 1, the soft capsule manufacturing system further includes: a glue supply barrel 10 which is communicated with the glue liquid tank 30 through a glue conveying pipe 13; the glue supply barrel 10 is provided with a glue barrel jacket water interlayer 12 on the periphery, a sealing cover at the top is provided with a second gas valve 11, and the second gas valve 11 is communicated with high-pressure gas. And a stop valve 14 and a flow regulating valve 15 are arranged on the upper rubber delivery pipe 13.
In one embodiment, the glue solution in the glue solution barrel 10 can be pumped to the glue solution tank 30 by using a high-pressure gas, and the high-pressure gas can be high-pressure air or high-pressure nitrogen. If necessary, the glue in the glue tank 10 can be pumped to the glue tank 30 in a fixed amount by a delivery pump.
In one embodiment, as shown in fig. 1, the soft capsule manufacturing system further includes: a conveyor belt 60 disposed below the spiral thermal cutting apparatus 50; wherein the conveyor 60 is adapted to receive the formed capsules and to drop the capsules to the next station.
The embodiments of the present invention have been described in detail, but the embodiments are merely examples, and the present invention is not limited to the embodiments described above. Any equivalent modifications and substitutions to those skilled in the art are also within the scope of the present invention. Accordingly, equivalent changes and modifications made without departing from the spirit and scope of the present invention should be covered by the present invention.
Claims (15)
1. A process for manufacturing soft capsules, comprising the steps of:
(1) the glue solution in the glue solution barrel is pumped into a sealed glue solution tank through a glue delivery pipe, and the liquid medicine is added into a liquid medicine tank;
(2) extruding the glue solution in the heat-preservation glue solution box through an outer ring discharge hole of an annular extrusion nest to form glue solution, and cooling and solidifying to form a rubber sheet;
(3) cutting the lower end of the adhesive rubber by adopting a spiral hot cutting device, and simultaneously injecting the liquid medicine in the liquid medicine tank into the rubber through an annular extrusion nested inner ring discharge port;
(4) after the rubber sheet injected with the liquid medicine is extruded for a period of time, the upper end of the adhesive rubber sheet is cut and bonded by the spiral hot cutting device again, and the formed capsules fall on the conveying belt and are conveyed to the next working section;
(5) repeating the steps (2) to (4) to realize the continuous production of the soft capsules.
2. The soft capsule manufacturing process according to claim 1, wherein in the step (1), the glue solution in the glue solution barrel is pumped to the glue solution tank by high-pressure gas or a delivery pump.
3. The process for preparing soft capsules according to claim 1, wherein in step (2), the cooling is carried out by room temperature cooling, room temperature air cooling and/or cold air cooling.
4. The process for manufacturing soft capsules according to claim 1, wherein in step (2), the thickness of the rubber is proportional to the extrusion flow rate of the glue solution.
5. The process for producing soft capsules according to claim 1, wherein in the step (3), the lower end of the rubber sheet is kept in a continuously extruded state while injecting a liquid medicine after shear bonding.
6. The process for manufacturing soft capsules according to claim 1, wherein in step (3), the liquid medicine is injected into the gelatin sheath by means of high-pressure gas pressure or a delivery pump.
7. The process for manufacturing soft capsules according to claim 1, wherein in step (4), the spiral hot cutting means shear-bonds the lower end of the next rubber sheet while shear-bonding the upper end of the rubber sheet.
8. A soft capsule manufacturing system, comprising:
a liquid medicine box (20) for providing liquid medicine for the system;
the glue solution box (30) is used for providing glue solution for the system;
at least one annular extrusion nesting sleeve (40) which is provided with an outer annular extrusion pipe (41) communicated with the glue liquid box (30) and an inner annular extrusion pipe (42) communicated with the liquid medicine box (20) which are coaxially arranged, and the outlet end of the inner annular extrusion pipe (42) extends out of the outlet end of the outer annular extrusion pipe (41) to be arranged; and
and the spiral hot cutting device (50) is correspondingly arranged at the outlet end of the annular extrusion nesting sleeve (40) and is used for carrying out hot cutting bonding on the rubber before and after the liquid medicine is injected.
9. The soft capsule manufacturing system according to claim 8, characterized in that the bottom of the drug solution tank (20) is communicated with the inner ring extrusion pipe (42) of each annular extrusion nest (40) through a liquid discharge pipe (23).
10. The soft capsule manufacturing system according to claim 9, characterized in that the drain (23) is formed by a main drain pipe provided with a main liquid medicine valve (24) and at least one branch drain pipe provided with a branch liquid medicine valve (25).
11. The soft capsule manufacturing system according to claim 9, wherein a first gas valve (21) is arranged on a sealing cover at the top of the liquid medicine box (20), and the first gas valve (21) is communicated with high-pressure gas.
12. The soft capsule manufacturing system according to claim 8, wherein the liquid medicine tank (20) is arranged in the liquid glue tank (30), and the liquid medicine tank (20) and the liquid glue tank (30) are respectively provided with a heat insulation layer (22) and a liquid glue jacket water interlayer (31) on the periphery.
13. The soft capsule manufacturing system according to claim 8, characterized in that the outlet ends of the outer ring extrusion tube (41) and the inner ring extrusion tube (42) are inwardly constricted in a pointed shape.
14. The soft capsule manufacturing system of claim 8, further comprising:
the glue supply barrel (10) is communicated with the glue liquid box (30) through a glue conveying pipe (13);
the glue supply barrel (10) is provided with a glue barrel jacket water interlayer (12) on the periphery, a sealing cover at the top is provided with a second gas valve (11), and the second gas valve (11) is communicated with high-pressure gas.
15. The soft capsule manufacturing system of claim 8, further comprising:
a conveyor belt (60) disposed below the helical thermal cutting apparatus (50);
wherein the conveyor (60) is adapted to receive the formed capsules and to drop the capsules to a further station.
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| CN202011088521.9A CN112168701B (en) | 2020-10-13 | 2020-10-13 | Soft capsule manufacturing process and manufacturing system thereof |
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| CN202011088521.9A CN112168701B (en) | 2020-10-13 | 2020-10-13 | Soft capsule manufacturing process and manufacturing system thereof |
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| CN113350182B (en) * | 2021-05-21 | 2023-03-17 | 江苏海王健康生物科技有限公司 | Soft capsule liquid medicine feedway of softgel production usefulness |
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