CN112168179A - Implantable hormone monitoring and auxiliary secretion device - Google Patents
Implantable hormone monitoring and auxiliary secretion device Download PDFInfo
- Publication number
- CN112168179A CN112168179A CN202011201444.3A CN202011201444A CN112168179A CN 112168179 A CN112168179 A CN 112168179A CN 202011201444 A CN202011201444 A CN 202011201444A CN 112168179 A CN112168179 A CN 112168179A
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- CN
- China
- Prior art keywords
- hormone
- circuit board
- integrated circuit
- implantable
- head pipe
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
Abstract
The invention discloses an implanted hormone monitoring and auxiliary secretion device, which comprises a head pipe body and a slow release pipe, wherein a storage battery is fixedly arranged in the head pipe body, an integrated circuit board is arranged in the head pipe body outside the storage battery, a plugging plate is clamped at the right end of the integrated circuit board, a hormone analysis integrated chip, a microprocessor and a signal transmitting module are welded on the integrated circuit board, and one end of a sampling needle is welded on the integrated circuit board; avoid whole implant body and equipment to advance the adhesion through the head body, conveniently seek and separate, simultaneously through the sampling needle in the head body, the tissue fluid sampling value hormone analysis integrated chip that will be filtered out by the alloy net cap, carry out the analysis to the appearance liquid and obtain current hormone index, then carry out information processing through microprocessor, transmit the signal to external equipment by the signal transmission module again, indicate, thereby realize real-time data acquisition, the convenient budget to the use dosage of implant.
Description
Technical Field
The invention relates to the technical field of endocrine medical instruments, in particular to an implantable hormone monitoring and auxiliary secretion device.
Background
At present, steroid contraceptives mainly comprise oral administration and injection administration dosage forms, and the former needs to be taken every day, so that the contraceptive failure is caused by frequent missed administration of the steroid contraceptives; the latter is administered by injection, and has the disadvantages of troublesome administration, local pain and subcutaneous irritation, and limited use. The existing long-acting subcutaneous contraceptive implant which is applied to clinic in recent years becomes an optional contraceptive mode, the silicon rubber is used as a carrier, after the effective period of use, the silicon rubber material of the carrier needs to be taken out, and due to the characteristics of the silicon rubber, the whole body is difficult to be peeled from the tissue after being adhered to the tissue, so that the use cost is increased.
Meanwhile, the existing implant is mostly felt by the human body, or whether the adopted dose is effective can be judged through blood sampling detection after the existing implant is used for a period of time, and meanwhile, the secretion of the hormone of the human body in different periods is different, so that the real-time monitoring is difficult, the maximum dose needs to be embedded, the contraceptive effect is ensured, however, the excessive medicament can influence the normal function of the human body, and various side effects occur, and therefore, the implantable hormone monitoring and auxiliary secretion device is provided.
Disclosure of Invention
The present invention is directed to an implantable hormone monitoring and secretion assisting device, which solves the above problems.
In order to achieve the purpose, the invention provides the following technical scheme:
the utility model provides an interior formula hormone of planting monitoring and supplementary secretion device, includes head body and slowly-releasing pipe, the intraductal fixed mounting of head body has the battery, is located be equipped with integrated circuit board in the head body in the battery outside, integrated circuit board's right-hand member has clamped the shutoff board, the last welding of integrated circuit board has hormone analysis integrated chip, microprocessor and signal transmission module, integrated circuit board welding has the one end of sampling needle, the other end of sampling needle runs through the shutoff board, the shutoff board spiral shell is equipped with the alloy net cap, the left end of head body is equipped with the tail jack, slowly-releasing pipe clamps in the tail jack, the cartridge has the medicament stick in the slowly-releasing pipe, the both ends of slowly-releasing pipe are all sealed through the latex shutoff.
Preferably, a sealing separator is arranged between the storage battery and the integrated circuit board, and the sealing separator is clamped in the head pipe body.
Preferably, the inner wall of the head pipe body is integrally formed with a first clamping protrusion and a second clamping protrusion, a sealing partition plate is clamped between the first clamping protrusions, and a plugging plate is clamped between the second clamping protrusions.
Preferably, the outer edge of the plugging plate is provided with a thread necking, and a sealing rubber gasket is attached to the table top on the left side of the thread necking.
Preferably, the sealing partition plate comprises a plate body, a concave groove is formed in the outer edge of the plate body, a positioning edge is formed on the plate body on the right side of the concave groove in an integrated mode, an inward-shrinkage flange is formed on the plate body on the left side of the concave groove in an integrated mode, and the height of the inward-shrinkage flange is half of the height of the positioning edge.
Preferably, the inner wall of the tail jack is integrally formed with an anti-slip corrugated flange.
Preferably, the release amount of the slow release tube is 10 mug to 40 mug per day.
Preferably, the medicament bar is prepared from trimethylene carbonate/p-dioxane ketone copolymer and gestodene, the trimethylene carbonate/p-dioxane ketone copolymer is in a molten state at the temperature of 50-90 ℃, then gestodene crystal powder is added, and the mixture is mixed and pressurized to form the bar shape.
Compared with the prior art, the invention has the beneficial effects that: the invention avoids the whole embedded body from being adhered with the assembly through the head pipe body, is convenient to search and separate, simultaneously analyzes the tissue fluid sampling value filtered by the alloy net cap through the sampling needle in the head pipe body to obtain the current hormone index through the hormone analysis integrated chip, then carries out information processing through the microprocessor, and transmits the signal to external equipment through the signal transmitting module to prompt, thereby realizing real-time data acquisition and being convenient for the budget of the dosage of the embedded agent.
Drawings
FIG. 1 is a main sectional structural view of the present invention;
FIG. 2 is a schematic view of a head tube structure according to the present invention;
fig. 3 is a schematic view of the sealing diaphragm structure of the present invention.
In the figure: 1. the device comprises a head pipe body, 2, a slow release pipe, 3, a storage battery, 4, an integrated circuit board, 5, a plugging plate, 6, an alloy net cap, 7, a hormone analysis integrated chip, 8, a microprocessor, 9, a signal emission module, 10, a sampling needle, 11, a sealing partition plate, 11a, a plate body, 11b, a positioning edge, 11c, a concave groove, 11d, a retraction flange, 12, a medicament rod, 13, a latex plugging block, 14, a first clamping protrusion, 15, a second clamping protrusion, 16, a sealing rubber gasket, 17, a tail jack, 18 and an anti-skid corrugated flange.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Examples
Referring to fig. 1-3, the present invention provides a technical solution: an implantable hormone monitoring and auxiliary secretion device comprises a head pipe body 1 and a slow release pipe 2, wherein the head pipe body 1 is made of non-toxic high polymer materials and cannot be degraded, the slow release pipe 2 stores a medicament stick 12, a storage battery 3 is fixedly arranged in the head pipe body 1 and provides electricity for the work of electronic elements on an integrated circuit board 4, the integrated circuit board 4 is arranged in the head pipe body 1 at the outer side of the storage battery 3 and is integrated with a circuit and auxiliary electronic elements, a plugging plate 5 is clamped at the right end of the integrated circuit board 4 and plugs the inlet end of the head pipe body 1 to avoid tissue fluid immersion and overlook the internal electronic elements, a hormone analysis integrated chip 7, a microprocessor 8 and a signal emission module 9 are welded on the integrated circuit board 4, the hormone analysis integrated chip 7 adopts the prior art to analyze the hormone indexes of the tissue fluid obtained by a sampling needle 10, the microprocessor 8 processes the moving data, the signal transmitting module 9 transmits and transmits data information, one end of a sampling needle 10 is welded on the integrated circuit board 4, the other end of the sampling needle 10 penetrates through the blocking plate 5, the tissue fluid filtered by the alloy mesh cap 6 is sampled to a hormone analysis machine chip, the blocking plate 5 is screwed with the alloy mesh cap 6 and is supported by titanium alloy to form a filtering cavity, so that the tissue fluid can better flow into the sampling needle 10, the left end of the head tube body 1 is provided with a tail jack 17 to provide a clamping base for the slow release tube 2, the slow release tube 2 is clamped in the tail jack 17 to realize effective combined installation, a medicament rod 12 is inserted in the slow release tube 2 to perform slow release of medicaments through the slow release tube 2, the function is realized based on medicament attributes, and two ends of the slow release tube 2 are both sealed by latex plugs 13, avoiding leakage and influencing the control of the slow release dosage.
Specifically, a sealing partition plate 11 is arranged between the storage battery 3 and the integrated circuit board 4, and the sealing partition plate 11 is clamped in the head pipe body 1.
Seal battery 3 again through sealed 11 to guarantee when sealed 11 reveals the back, battery 3 still can not be corroded, thereby guarantee user's safety.
Specifically, the inner wall of the head pipe body 1 is integrally formed with a first clamping protrusion 14 and a second clamping protrusion 15, a sealing partition plate 11 is clamped between the first clamping protrusions 14, and a blocking plate 5 is clamped between the second clamping protrusions 15.
Through first protruding 14 of card and the protruding 15 of second card for carry out effectual spacing installation to sealed bulkhead 11 and shutoff board 5, avoid appearing sliding and extrusion problem.
Specifically, the outer edge of the plugging plate 5 is provided with a threaded neck, and a sealing rubber gasket 16 is attached to the table surface on the left side of the threaded neck.
The matching of the alloy mesh cap 6 is realized through the thread necking, and the sealing rubber gasket 16 is further sealed under the screw assembling extrusion.
Specifically, sealed baffle 11 includes plate body 11a, for sealed baffle 11's foundation structure, depressed groove 11c has been seted up to plate body 11 a's outer fringe, coordinates the position of sealed baffle 11 to first calorie of protruding 14 inter-position limits, plate body 11a integrated into one piece on depressed groove 11c right side has location edge 11b, to the biggest position of going left limit, avoids the position, the left plate body 11a integrated into one piece of depressed groove 11c has the flange 11d that contracts in, the height of the flange 11d that contracts in is the half of the height of location edge 11b for first calorie of protruding 14 can slide into depressed groove 11c, and it is spacing to reply the position simultaneously.
Specifically, the inner wall of the tail insertion hole 17 is integrally formed with a non-slip corrugated flange 18.
The stability of the slow release tube 2 after being inserted into the tail insertion hole 17 is improved, and accidental falling is avoided.
Specifically, the release amount of the slow release tube 2 is 10 mug to 40 mug per day.
The medicine release amount is determined by the effective medicine release surface area of the slow release tube 2, and the slow release tube 2 with different medicine release amounts is adopted according to different users.
Specifically, the medicine stick 12 is made of trimethylene carbonate/p-dioxane ketone copolymer and gestodene, the trimethylene carbonate/p-dioxane ketone copolymer is in a molten state at the temperature of 50 ℃ to 90 ℃, then gestodene crystal powder is added, and the mixture is mixed and pressurized to form a stick shape.
The whole medicine can be completely dissolved after use, no residue is generated, the harm to human body is reduced, and the diameter and the length of the rod shape are matched and manufactured according to the medicine release pipe.
The working principle is as follows: during the use, with the slow-release tube 2 cartridge that splendid attire has medicament stick 12 in the tail jack 17 of head body 1, implant the subcutaneous through minimal access surgery, based on the effect of alloy screen panel, make sampling needle 10 be in the cavity, the alloy screen panel is pressed the tissue in the filter paper cavity simultaneously, sampling between sampling needle 10 and convey tissue fluid sample to hormone analysis integrated chip 7 and carry out the analysis, after the data that obtain is handled well via microprocessor 8, control signal emission module 9 transmits data message to external data, and tissue fluid passes through slow-release tube 2 and immerses in medicament stick 12, the slow-release tube 2 control is slowly-released two simultaneously, realize the real-time supervision to endocrine hormone, supplementary hormone's secretion simultaneously.
In the description of the present invention, unless otherwise expressly specified or limited, the terms "mounted," "connected," and "fixed" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral part; can be mechanically or electrically connected; either directly or indirectly through intervening media, either internally or in any other relationship. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
The standard parts used in the invention can be purchased from the market, the special-shaped parts can be customized according to the description of the specification and the accompanying drawings, the specific connection mode of each part adopts conventional means such as mature bolts, rivets, welding and the like in the prior art, the machines, the parts and equipment adopt conventional models in the prior art, and the circuit connection adopts the conventional connection mode in the prior art, so that the detailed description is omitted.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. The utility model provides an implanted hormone monitoring and supplementary secretion device, includes head body (1) and slowly-releasing pipe (2), its characterized in that: a storage battery (3) is fixedly arranged in the head pipe body (1), an integrated circuit board (4) is arranged in the head pipe body (1) positioned outside the storage battery (3), a plugging plate (5) is clamped at the right end of the integrated circuit board (4), a hormone analysis integrated chip (7), a microprocessor (8) and a signal emission module (9) are welded on the integrated circuit board (4), one end of a sampling needle (10) is welded on the integrated circuit board (4), the other end of the sampling needle (10) penetrates through the plugging plate (5), the plugging plate (5) is provided with an alloy mesh cap (6) in a threaded manner, the left end of the head pipe body (1) is provided with a tail insertion hole (17), the slow release tube (2) is clamped in the tail jack (17), a medicament rod (12) is inserted in the slow release tube (2), both ends of the slow release tube (2) are sealed by latex plugs (13).
2. The implantable hormone monitoring and auxiliary secretion device according to claim 1, wherein: a sealing partition plate (11) is arranged between the storage battery (3) and the integrated circuit board (4), and the sealing partition plate (11) is clamped in the head pipe body (1).
3. The implantable hormone monitoring and auxiliary secretion device according to claim 2, wherein: the inner wall of the head pipe body (1) is integrally formed with a first clamping protrusion (14) and a second clamping protrusion (15), a sealing partition plate (11) is clamped between the first clamping protrusions (14), and a plugging plate (5) is clamped between the second clamping protrusions (15).
4. The implantable hormone monitoring and auxiliary secretion device according to claim 1, wherein: the outer edge of the plugging plate (5) is provided with a thread necking, and a sealing rubber gasket (16) is attached to the table top on the left side of the thread necking.
5. The implantable hormone monitoring and auxiliary secretion device according to claim 3, wherein: sealed baffle (11) package rubbing board body (11a), depressed groove (11c) have been seted up to the outer fringe of plate body (11a), plate body (11a) integrated into one piece on depressed groove (11c) right side has location reason (11b), plate body (11a) integrated into one piece on the left of depressed groove (11c) has the flange (11d) that contracts in, the height of the flange (11d) that contracts in is the half of location reason (11b) height.
6. The implantable hormone monitoring and auxiliary secretion device according to claim 1, wherein: and an anti-skid corrugated flange (18) is integrally formed on the inner wall of the tail insertion hole (17).
7. The implantable hormone monitoring and auxiliary secretion device according to claim 1, wherein: the medicine release amount of the slow release pipe (2) is 10 mug-40 mug per day.
8. The implantable hormone monitoring and auxiliary secretion device according to claim 1, wherein: the medicine stick (12) is made of trimethylene carbonate/p-dioxane ketone copolymer and gestodene, the trimethylene carbonate/p-dioxane ketone copolymer is in a molten state at the temperature of 50-90 ℃, then gestodene crystal powder is added, and the mixture is mixed and pressurized to form a stick shape.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011201444.3A CN112168179A (en) | 2020-11-02 | 2020-11-02 | Implantable hormone monitoring and auxiliary secretion device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011201444.3A CN112168179A (en) | 2020-11-02 | 2020-11-02 | Implantable hormone monitoring and auxiliary secretion device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112168179A true CN112168179A (en) | 2021-01-05 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011201444.3A Pending CN112168179A (en) | 2020-11-02 | 2020-11-02 | Implantable hormone monitoring and auxiliary secretion device |
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| Country | Link |
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| CN (1) | CN112168179A (en) |
Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5556421A (en) * | 1995-02-22 | 1996-09-17 | Intermedics, Inc. | Implantable medical device with enclosed physiological parameter sensors or telemetry link |
| US20030171711A1 (en) * | 2002-03-06 | 2003-09-11 | Rohr William L. | Closed-loop drug delivery system |
| US20030191499A1 (en) * | 2001-01-18 | 2003-10-09 | Vladimir Kalina | Apparatus for inducing an immune response in cancer therapy |
| US20040087982A1 (en) * | 2002-08-07 | 2004-05-06 | Eskuri Alan David | Electroactive polymer actuated medical devices |
| US20040133089A1 (en) * | 1999-04-07 | 2004-07-08 | Endonetics, Inc. | Implantable monitoring probe |
| US20050245902A1 (en) * | 2002-02-08 | 2005-11-03 | Brian Cornish | Substance delivery device |
| US20060100531A1 (en) * | 2003-06-17 | 2006-05-11 | Raymond Moser | Instrumented retrievable implantable device |
| CN101209238A (en) * | 2006-12-27 | 2008-07-02 | 辽宁省计划生育科学研究院 | Biological degradation type long-acting hypodermal contraception implant containing gestodene and preparation thereof |
| US20090259217A1 (en) * | 2008-04-09 | 2009-10-15 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Methods and systems associated with delivery of one or more agents to an individual |
| US20090299156A1 (en) * | 2008-02-20 | 2009-12-03 | Dexcom, Inc. | Continuous medicament sensor system for in vivo use |
| CN106821328A (en) * | 2017-03-16 | 2017-06-13 | 中国科学院半导体研究所 | Totally implantable optical modalities |
| JP2019042054A (en) * | 2017-08-31 | 2019-03-22 | 株式会社トップ | Connector system |
| CN111419293A (en) * | 2020-04-30 | 2020-07-17 | 安翰科技(武汉)股份有限公司 | Sampling/drug delivery capsule |
-
2020
- 2020-11-02 CN CN202011201444.3A patent/CN112168179A/en active Pending
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5556421A (en) * | 1995-02-22 | 1996-09-17 | Intermedics, Inc. | Implantable medical device with enclosed physiological parameter sensors or telemetry link |
| US20040133089A1 (en) * | 1999-04-07 | 2004-07-08 | Endonetics, Inc. | Implantable monitoring probe |
| US20030191499A1 (en) * | 2001-01-18 | 2003-10-09 | Vladimir Kalina | Apparatus for inducing an immune response in cancer therapy |
| US20050245902A1 (en) * | 2002-02-08 | 2005-11-03 | Brian Cornish | Substance delivery device |
| US20030171711A1 (en) * | 2002-03-06 | 2003-09-11 | Rohr William L. | Closed-loop drug delivery system |
| US20040087982A1 (en) * | 2002-08-07 | 2004-05-06 | Eskuri Alan David | Electroactive polymer actuated medical devices |
| US20060100531A1 (en) * | 2003-06-17 | 2006-05-11 | Raymond Moser | Instrumented retrievable implantable device |
| CN101209238A (en) * | 2006-12-27 | 2008-07-02 | 辽宁省计划生育科学研究院 | Biological degradation type long-acting hypodermal contraception implant containing gestodene and preparation thereof |
| US20090299156A1 (en) * | 2008-02-20 | 2009-12-03 | Dexcom, Inc. | Continuous medicament sensor system for in vivo use |
| US20090259217A1 (en) * | 2008-04-09 | 2009-10-15 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Methods and systems associated with delivery of one or more agents to an individual |
| CN106821328A (en) * | 2017-03-16 | 2017-06-13 | 中国科学院半导体研究所 | Totally implantable optical modalities |
| JP2019042054A (en) * | 2017-08-31 | 2019-03-22 | 株式会社トップ | Connector system |
| CN111419293A (en) * | 2020-04-30 | 2020-07-17 | 安翰科技(武汉)股份有限公司 | Sampling/drug delivery capsule |
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