CN112156242B

CN112156242B - Drawing device

Info

Publication number: CN112156242B
Application number: CN202011059508.0A
Authority: CN
Inventors: 郭靖; 周亮; 朱冠铭; 成卓奇; 蔡述庭
Original assignee: Guangdong University of Technology
Current assignee: Guangdong University of Technology
Priority date: 2020-09-30
Filing date: 2020-09-30
Publication date: 2023-04-07
Anticipated expiration: 2040-09-30
Also published as: CN112156242A

Abstract

The invention discloses a pumping-out device which comprises a liquid collecting unit and a negative pressure suction unit, wherein the liquid collecting unit is used for collecting effusion on the surface of a tissue to be detected; the negative pressure suction unit is communicated with the liquid collecting unit and is used for pumping accumulated liquid collected by the liquid collecting unit away from the surface of the tissue to be detected, the liquid collecting unit comprises a sucker which is used for collecting the accumulated liquid on the surface of the tissue to be detected, and the sucker is communicated with the liquid collecting unit. The invention can pump away the body fluid generated on the surface of the tissue to be measured during measurement, avoids the phenomenon of effusion, greatly reduces the influence of the effusion on the measurement of the electrical impedance value on the surface of the tissue, and thus effectively reduces the possibility of misdiagnosis.

Description

Drawing device

Technical Field

The invention relates to the technical field of medical instruments, in particular to a drawing-out device.

Background

Normal cells may be cancerous to become malignant cells due to stimulation by exogenous factors such as bad living habits, environmental pollution, or endogenous factors such as DNA. For patients with initial tumors, if the patients can timely and effectively detect whether the abnormal parts are cancerated, the patients can timely seek medical advice to obtain effective treatment, and the survival rate is greatly improved. Currently, cancer cell examination in clinical medicine mostly uses pathological examination, tumor marker assay, genetic testing or imaging examination. Besides the many process steps, long time consumption and high cost, most of the above methods require invasive or radioactive examination on the patient, which often causes additional damage to the patient. On the other hand, during the operation, the doctor needs to judge the boundary of the tumor in real time and accurately cut the tumor. The existing technology is difficult to assist doctors to accurately find the boundary of the lesion tissue. Therefore, doctors often need to resect a large amount of healthy tissue around the tumor to ensure that the tumor can be resected cleanly.

In recent years, the application of Bio-Electrical impedance Spectroscopy (BIS) sensing technology in cancer detection has been a research focus. Bioelectrical impedance is measured by injecting an excitation electrical signal into the target tissue and measuring the electrical signal returned therefrom for analysis. Because the water and mineral content, cell membrane permeability, and cell packing density and direction in tumor cells are often greatly different from those of healthy tissues, the electrical characteristics of the tumor cells are obviously different from those of the healthy tissues, and therefore, the tissue types can be identified through the calculated electrical impedance characteristics. EBI sensing modalities have been demonstrated in the detection of various cancers, such as the liver, larynx and kidney. Although the bioelectrical impedance spectrum analysis sensing technology can detect the cancerous tissue, in the testing process, the liquid accumulation is caused by the body fluid on the surface of the tissue to be detected, and the liquid accumulation influences the electrical impedance value of the tissue to be detected, so that the possibility of misdiagnosis is high.

To this end, a drawing-off device is proposed.

Disclosure of Invention

Aiming at the defects in the prior art, the invention aims to provide a drawing device which can draw away body fluid generated on the surface of a tissue to be measured during measurement, avoid the phenomenon of effusion and greatly reduce the influence of the effusion on the surface of the tissue on the measurement of an electrical impedance value, thereby effectively reducing the possibility of misdiagnosis and solving the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme:

a pump-off device comprising:

the liquid collecting unit is used for collecting the accumulated liquid on the surface of the tissue to be detected;

the negative pressure suction unit is communicated with the liquid collection unit and is used for pumping the accumulated liquid collected by the liquid collection unit away from the surface of the tissue to be detected.

Preferably, the liquid collecting unit comprises a sucker, the sucker is used for collecting accumulated liquid on the surface of the tissue to be detected, and the sucker is communicated with the liquid collecting unit.

Preferably, the sucker is a horn-shaped sucker, the larger end of the sucker is of an open structure, and the smaller end of the sucker is of a closed structure.

Preferably, the larger end of the suction cup is used for being attached to the surface of the tissue to be detected, and the smaller end of the suction cup is used for being connected with the negative pressure suction unit.

Preferably, the larger end wall edge of the suction cup is of a rounded configuration.

Preferably, the negative pressure suction unit comprises a guide tube and a pipette, the guide tube is fixedly mounted on the end wall of the smaller end of the sucker, one end of the guide tube extends into the sucker, the pipette is used for providing negative pressure for the guide tube, the suction port of the pipette is communicated with the other end of the guide tube, and the pipette is arranged as a needle tube.

Preferably, the negative pressure suction unit comprises a guide tube and a rubber air bag, the guide tube is fixedly mounted on the end wall of the smaller end of the sucker, one end of the guide tube extends into the sucker, the rubber air bag is used for providing negative pressure for the guide tube, and the rubber air bag is communicated with the other end of the guide tube.

As preferred, the vacuum aspiration unit includes that guiding tube, hydrops are taken out from equipment and hydrops collecting device, guiding tube fixed mounting be in on the less end wall of sucking disc, just the one end of guiding tube stretches into the inside of sucking disc, the hydrops be taken out from equipment respectively with the other end of guiding tube with hydrops collecting device is linked together.

Preferably, the accumulated liquid pumping and separating device is a negative pressure pump, the accumulated liquid collecting device is a container, a water suction port of the negative pressure pump is communicated with one end, away from the sucker, of the guide pipe, a water outlet of the negative pressure pump is communicated with the container through a pipeline, the container is a measuring cup, and the measuring cup is a plastic measuring cup.

Preferably, when the larger end of the sucking disc is attached to the surface of the tissue to be detected, one end, located inside the sucking disc, of the guide pipe is attached to the surface of the tissue to be detected, and a notch is reserved in the edge of the end wall of one end, located inside the sucking disc, of the guide pipe.

In summary, the invention mainly has the following beneficial effects:

the invention can pump away the body fluid generated on the surface of the tissue to be measured during measurement, avoids the phenomenon of effusion, greatly reduces the influence of the effusion on the measurement of the electrical impedance value on the surface of the tissue, and thus effectively reduces the possibility of misdiagnosis.

Drawings

FIG. 1 is a schematic structural view of a drawing apparatus according to the present invention;

fig. 2 is a schematic structural view of the extraction device of embodiment 1;

fig. 3 is a schematic structural view of the extraction device of embodiment 2;

FIG. 4 is a schematic structural view of a drawing-out apparatus according to embodiment 3;

FIG. 5 is a schematic view of an assembly structure of the suction cup and the guide tube according to the present invention.

Drawings

11. A suction cup; 21. a guide tube; 221. a needle tube; 222. a rubber air bag; 31. a negative pressure pump; 41. and (4) measuring the cup.

Detailed Description

The present invention is described in further detail below with reference to figures 1-5.

Example 1

A pumping-out device comprises a liquid collecting unit and a negative pressure suction unit, wherein the liquid collecting unit is used for collecting effusion on the surface of a tissue to be detected; the negative pressure suction unit is communicated with the liquid collection unit and is used for pumping effusion collected by the liquid collection unit away from the surface of the tissue to be detected.

The liquid collecting unit comprises a sucker, the sucker is used for collecting accumulated liquid on the surface of the tissue to be detected, and the sucker is communicated with the liquid collecting unit.

The sucker is a horn-shaped sucker, the larger end of the sucker is of an open structure, and the smaller end of the sucker is of a closed structure.

The larger end of the sucker is used for being attached to the surface of a tissue to be detected, and the smaller end of the sucker is used for being connected with the negative pressure suction unit.

Wherein, the edge of the end wall of the larger end of the sucker is in a rounded corner structure.

The negative pressure suction unit comprises a guide pipe and a pipette, the guide pipe is fixedly installed on the end wall of the smaller end of the sucker, one end of the guide pipe extends into the sucker, the pipette is used for providing negative pressure for the guide pipe, an air suction port of the pipette is communicated with the other end of the guide pipe, and the pipette is arranged to be a needle tube. The negative pressure suction unit consisting of the guide tube and the pipette ensures that the device has convenient operation and lower processing cost.

Through adopting above-mentioned technical scheme, the device of taking out that sets up comprises album of liquid unit and negative pressure suction unit, and album of liquid unit comprises the sucking disc, and negative pressure suction unit comprises guiding tube and pipette, utilizes sucking disc, guiding tube and pipette to cooperate can in time take out the body fluid that the tissue surface produced that awaits measuring when using, avoids producing the tissue surface that awaits measuring and produces hydrops, and the hydrops interference when reducing the sampling effectively reduces the possibility of misdiagnosis.

Example 2

The present embodiment is different from embodiment 1 in that: the negative pressure suction unit comprises a guide tube and a rubber air bag, the guide tube is fixedly installed on the end wall of the smaller end of the sucker, one end of the guide tube extends into the sucker, the rubber air bag is used for providing negative pressure for the guide tube, and the rubber air bag is communicated with the other end of the guide tube.

Through adopting above-mentioned technical scheme, the negative pressure suction unit that sets up comprises guiding tube and rubber gasbag, can absorb the tissue hydrops in the sucking disc with containing the rubber gasbag that prevents suck-back, compares in the extraction of needle tubing, and the doctor only needs one hand to press to hold between the fingers can be with tissue hydrops extraction, operates simplyr.

Example 3

The present embodiment is different from embodiment 1 in that: the negative pressure suction unit comprises a guide pipe, a liquid accumulation pumping device and a liquid accumulation collecting device, wherein the guide pipe is fixedly installed on the end wall of the smaller end of the sucker, one end of the guide pipe extends into the inside of the sucker, and the liquid accumulation pumping device is respectively communicated with the other end of the guide pipe and the liquid accumulation collecting device.

Wherein, the hydrops is taken out from equipment and is the negative pressure pump, hydrops collecting device is the container, the water sucking mouth of negative pressure pump with the guiding tube is kept away from the one end of sucking disc is linked together, just the delivery port of negative pressure pump pass through the pipeline with the container is linked together, the container is the graduated flask, the graduated flask is the plastics graduated flask, works as the great end laminating of sucking disc is at the tissue that awaits measuring when on the surface the guiding tube is located the inside one end of sucking disc is laminated with the surface of the tissue that awaits measuring mutually, the guiding tube is located the inside one end wall edge reservation of sucking disc has the breach, and the breach is used for getting into hydrops or body fluid for the device is taken out from the effect of hydrops or body fluid more thoroughly.

By adopting the technical scheme, the accumulated liquid in the sucker is pumped away by the negative pressure pump, and the negative pressure pump can be parameterized, so that the control is accurate by means of the feedback of the air pressure sensor, and the negative pressure in the device can not be overlarge to damage tissues, so that the safety performance of the device is better; secondly, set up the container into the graduated flask, be convenient for directly read the volume of the hydrops of taking out, the volume of the hydrops of taking out also can regard as a consideration factor of tissue pathological change.

The working method comprises the following steps: the electrode at the bottom of the sucker is contacted with the surface of the tissue to be measured, the electrical impedance value of the tissue to be measured is measured to be Z1, and the electrical impedance value is recorded; the effusion attached to the surface of the tissue to be detected is pumped away by the negative pressure suction unit; in the process of drawing, in each 1 Delta T in i time intervals Delta T, the electrical impedance value of the tissue to be measured is Zi, i =1,2,3,4 \8230; drawing a function graph with 1 delta T as an x axis and an electrical impedance value as a y axis, wherein each time interval delta T and the measured electrical impedance are x axis and y axis coordinates, and smoothly connecting each point, if the tail end, namely the latest measured 5 electrical impedance values, approach to a line parallel to the x axis, applying a displacement interference on the sucker to enable the sucker to shake, then measuring the electrical impedance value of the tissue to be measured, and if the measured electrical impedance value falls in an interval formed by the minimum value and the maximum value of the 5 electrical impedance values, considering that the sucker is stably adsorbed on the tissue to be measured; if the measured electrical impedance value does not fall in the interval formed by the minimum value and the maximum value in the 5 electrical impedance values, the working method is carried out again.

The parts not involved in the present invention are the same as or can be implemented by the prior art. The present embodiment is only for explaining the present invention, and it is not limited to the present invention, and those skilled in the art can make modifications without inventive contribution to the present embodiment as required after reading the present specification, but all of them are protected by patent law within the scope of the present invention.

Claims

1. A method of operating a pump-out device, the pump-out device comprising:

the negative pressure suction unit is communicated with the liquid collecting unit and is used for pumping accumulated liquid collected by the liquid collecting unit away from the surface of the tissue to be detected, the liquid collecting unit comprises a sucker which is used for collecting the accumulated liquid on the surface of the tissue to be detected, and the sucker is communicated with the liquid collecting unit;

the sucker is a horn-shaped sucker, the larger end of the sucker is of an open structure, and the smaller end of the sucker is of a closed structure; the larger end of the sucker is used for being attached to the surface of the tissue to be detected, and the smaller end of the sucker is used for being connected with the negative pressure suction unit; an electrode is arranged at the bottom of the sucker, the negative pressure suction unit comprises a guide pipe, the guide pipe is fixedly arranged on the end wall of the smaller end of the sucker, and one end of the guide pipe extends into the sucker;

a notch is reserved on the edge of the end wall of one end of the guide tube, which is positioned in the sucker,

the working method comprises the following steps:

contacting the electrode at the bottom of the sucker with the surface of the tissue to be tested, testing the electrical impedance value of the tissue to be tested, and recording the electrical impedance value as Z1;

the negative pressure suction unit is used for pumping away the effusion attached to the surface of the tissue to be detected;

in the process of drawing, setting a time interval of delta T, testing the electrical impedance value of the tissue to be tested every 1 delta T, and recording the electrical impedance value as Zi, wherein i =2,3,4 \8230;

drawing a function graph after the extraction is finished, wherein the x axis in the function graph is each time interval delta T, and the y axis in the function graph is the electrical impedance value Zi;

the last measured 5 values of the electrical impedance were obtained:

if the 5 electrical impedance values approach a line parallel to the x axis, applying a displacement interference to the sucker to enable the sucker to shake, continuing to measure the electrical impedance value of the tissue to be measured, and judging the electrical impedance value measured again:

if the re-measured electrical impedance value falls in the interval of the minimum value and the maximum value in the 5 electrical impedance values, the sucker is considered to be stably adsorbed on the tissue to be measured;

and if the measured electrical impedance value does not fall in the interval formed by the minimum value and the maximum value in the 5 electrical impedance values, the working method is reused for working.

2. A method of operating a pump-off device according to claim 1, characterized in that: the negative pressure suction unit comprises a pipette, the pipette is used for providing negative pressure for the guide pipe, an air suction port of the pipette is communicated with the other end of the guide pipe, and the pipette is arranged as a needle pipe.

3. A method of operating a pump-off device according to claim 1, characterized in that: the negative pressure suction unit comprises a rubber air bag which is used for providing negative pressure for the guide tube, and the rubber air bag is communicated with the other end of the guide tube.

4. The method of claim 1, further comprising the step of: the negative pressure suction unit comprises effusion pumping equipment and effusion collecting equipment, wherein the effusion pumping equipment is respectively communicated with the other end of the guide pipe and the effusion collecting equipment.

5. A method of operating a pump-off device according to claim 4, wherein: the hydrops is taken out from equipment and is the negative pressure pump, hydrops collecting device is the container, the water sucking mouth of negative pressure pump with the guiding tube is kept away from the one end of sucking disc is linked together, just the delivery port of negative pressure pump pass through the pipeline with the container is linked together, the container is the graduated flask, the graduated flask is the plastics graduated flask.

6. The method of claim 1, further comprising the step of: the edge of the end wall of the larger end of the sucker is of a rounded structure.