CN112155843A

CN112155843A - Flow-control injector for drug delivery

Info

Publication number: CN112155843A
Application number: CN202011070946.7A
Authority: CN
Inventors: 杜秋月; 陈文静; 赵阳; 田斌
Original assignee: Beijing Technology and Business University
Current assignee: Beijing Technology and Business University
Priority date: 2020-10-09
Filing date: 2020-10-09
Publication date: 2021-01-01

Abstract

The invention discloses a flow control infusion set for drug delivery, and relates to the field of medical instruments. The micro-motor based injector comprises an injection device for outputting the inhibitor, an advancing device for extruding the inhibitor to a required position, and a storage device for containing the inhibitor. The injection device is divided into a tool bit, a tip, a fine needle and a needle tube from top to bottom; the reciprocating propulsion device comprises an internal micro motor, an external protective housing, a screw rod piece, a nut body and a piston; the storage device is internally provided with an accommodating box which can quantitatively load the medicine required in the process of injecting the medicine into human eyes. The invention can continuously and uniformly cover quantitative medicine on the surface of the eyeball in the operation, the pump force can better control the delivered dose, the operation convenience is improved, the speed is controllable, the operation is sensitive, and the defects of low precision and difficult control caused by the manual pushing type of the traditional injector at present can be overcome.

Description

Flow-control injector for drug delivery

Technical Field

The invention relates to the field of medical instruments, in particular to a flow control injector for drug delivery.

Background

With the continuous improvement and popularization of microsurgery technology, ophthalmic surgery is more and more, the surgery process is more delicate, and the operation is more accurate. Cataract is a common eye disease at present, clinically, cataract ultrasonic emulsification surgery is generally adopted, but postoperative patients can generate some complications, such as ametropia, dry eye, corneal astigmatism and the like, and after-cataract is also one of the eye diseases. The secondary cataract is caused by that epithelial cells remained on crystalline lens proliferate after cataract operation, lens fibers are generated to move to the capsular sac and are attached by the capsular sac, and a membrane is generated in the pupil area, so that the capsular sac of cataract patients is turbid, the vision is gradually reduced, and the serious patients cause blindness. Therefore, in order to ensure the safety of the operation and reduce the recurrence rate, the medicine of the inhibitor can be used for conservative treatment. The importance of inhibitors in the field of cataract surgery is now recognized and acknowledged by an increasing number of people as indispensable adjunctive drugs in the treatment of cataract microsurgery.

Traditional injectors for inhibitor delivery in the current market are all manual injections, which are slightly careless excessive or too fast, and have great potential safety hazards, which reduce the safety of ophthalmic surgery and the efficiency of the surgical procedure. The common ophthalmologic operation injector meets basic operation requirements, can deliver the inhibitor to a designated position, still needs to manually push and deliver the inhibitor, and is inconvenient to use and increases the labor burden of doctors. At present, the device for conveying the inhibitor in the hospital is biased to be manual, and the efficiency is unstable, so that an injector capable of conveying the inhibitor quantitatively is needed, the inhibitor is conveyed and inhibited accurately, quantitatively and stably, and the safety of surgical treatment and the success rate of surgery are improved.

Based on the above, it is important in ophthalmic surgery to design a bolus device capable of accurately delivering a metered dose of an inhibitor.

Disclosure of Invention

The invention aims to provide a semi-automatic injector which can continuously and uniformly cover a quantitative inhibitor on the surface of a cornea in an operation, can better control the delivered dose by the motor force, increases the convenience of the operation, has controllable speed and sensitive operation, and can make up the defects of low precision and difficult control caused by the manual pushing type of the current scalpel.

In order to achieve the above object, the present invention provides the following technical solutions.

A flow-controlled drug delivery syringe comprises an injection device for delivering a drug, a storage device for containing the drug, and a propelling device for propelling the drug to a desired site.

The injection device is divided into a tool bit, a tip, a fine needle and a needle tube; the storage device is communicated with a piston at the front end of the propelling device to form a closed cylindrical accommodating cavity, and an accommodating box with the inner diameter smaller than that of the storage device is arranged in the cylindrical inner cavity; the propelling device comprises a micro motor, an external protection housing, a screw rod piece, a nut body and a piston, wherein the micro motor is mounted at the tail part of the external protection housing.

The flow control injection device for drug delivery is axially provided with an injection device, a storage device and a propulsion device, wherein the storage device is positioned in the middle, and the injection device and the propulsion device are positioned at two ends of the opposite sides of the storage device.

Furthermore, the cross section of the cutter head in the injection device is in a fan-shaped shovel shape and is positioned at the front end of the injection device, arc-shaped outlet connectors are symmetrically obliquely cut out of the outer side of the tip, and one side connector of the tip is fixedly assembled with the cutter head for transition.

Furthermore, the injection device utilizes a wet etching process, the pre-etched cutter head made of silicon materials is placed in a liquid environment filled with reagents for reaction, the cross section of the cutter head protected by the resist is not corroded, the etching section is arc-shaped, the damage to other devices is small, and the process requirement of smoothness and stability of the cutter head is met.

Furthermore, in the structure of the injection device, the tool bit, the tip, the fine needle and the needle tube are integrally formed by injection molding, and the aperture of each section is gradually increased.

Furthermore, the accommodating box is a semi-cylindrical bin and is driven by the piston to generate volume change; a partition plate is arranged at the joint of the cylindrical inner cavity and the propelling device to prevent the accommodating box from moving up and down with residual medicine.

Further, hold the top of box uncovered, the baffle inboard is equipped with circular recess, and the outside parcel sealing washer, the baffle is radially placed, and the edge axial is upwards slided down, covers the medicine surface.

Further, the feed screw nut piece comprises a feed screw piece body and a nut body, the nut body is fixedly connected with the central rod, the feed screw piece body is rotatably connected with the threaded groove of the nut body and is far away from one end of the central rod, and the feed screw piece penetrates through the cylindrical inner cavity and is fixedly connected with the piston.

Furthermore, the central rod and the nut body rotate to drive the screw rod piece to move up and down, and the piston slides to achieve the reciprocating motion effect.

Furthermore, the outer protective cover shell is loaded outside the propelling device, and rubber gaskets are arranged between the outer protective cover shell and the propelling device. A miniature motor in the propulsion device is fixedly provided with an electromagnetic coil rack, and the coil rack is provided with a bearing connected with a motor cavity.

Furthermore, a button battery is arranged on the tail wing of the propelling device, and the position of the button battery corresponds to the position of the micro motor bearing.

Compared with the prior art, the drug delivery flow control injector based on the micro motor has the following beneficial effects:

the drug delivery flow-control injector based on the micro motor provided by the invention is etched by a wet method, has a fine operation mechanical head, and the front end cutter head is designed into a groove for placing drugs, so that the injector is beneficial to safely passing through a small incision of the anterior chamber, is convenient to enter and exit a surgical site, and avoids damaging adjacent tissues. The design of the external protective cover shell considers the use habit of a doctor in the operation process and the hand man-machine theory. And the button cell is adopted, so that the operation is convenient and quick. The micro motor and the screw rod and nut mechanism are adopted for pushing, so that the medicine can be quantitatively and stably injected, the adjusting performance is high, the pushing device is not in direct contact with the medicine, and the inhibitor is not easy to generate secondary pollution.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the embodiments are briefly described below.

Fig. 1 schematically shows an overall structural view of the present invention.

Fig. 2 schematically shows a structure of the housing of the present invention.

Fig. 3 is a schematic view of the injection device of the present invention.

Description of reference numerals: 1. a cutter head; 2. a tip; 3. fine needles; 4. a needle tube; 5. accommodating the box; 6. a piston; 7. a partition plate; 8. a nut body; 9. a wire rod member; 10. a center pole; 11. a bearing; 12. a micro motor; 13. an outer protective housing; 14. a button cell.

Detailed Description

The present invention will be described in further detail with reference to the accompanying drawings.

The present embodiment is only for explaining the present invention, and it is not limited to the present invention, and those skilled in the art can make modifications of the present embodiment as necessary without making a contribution thereto after reading the present specification, but all are protected by patent laws within the scope of the claims of the present invention.

The present embodiments relate to a flow-controlled injector for drug delivery, which is based on a micro-motor. As shown in fig. 1, the injector comprises an injection means for delivering the drug and a reservoir means containing the drug and an advancing means for injecting the drug output to the desired site.

The injection device is divided into a tool bit 1, a tip 2, a fine needle 3 and a needle tube 4; the storage device is internally provided with an accommodating box 5 and a piston 6; the propulsion device comprises a wire rod part 9, a nut body 8, a central rod 10, a micro motor 12, an external protective cover 13 and a piston.

As shown in fig. 3, the cross section of the cutting head 1 in the injection device is in a sector shovel shape and is positioned at the front end of the injection device, arc-shaped outlet joints are symmetrically and obliquely cut out of the outer side of the tip 2, and one side joint of the tip 2 is fixedly assembled with the cutting head 1 for transition. In the injection device, the tool bit 1, the tip 2, the fine needle 3 and the needle tube 4 adopt an injection molding integral forming process, and the aperture of each section is gradually increased.

The injection device utilizes a wet etching process, a pre-etched tool bit made of silicon materials is used for masking a part of the thin film, the pre-etched tool bit is placed in a liquid environment filled with a reagent, the cross section of the tool bit protected by the corrosion inhibitor is not corroded, and the etched cross section is arc-shaped, so that the process requirements of fine etching, smoothness and stability of the edge of the tool bit 1 are met.

The storage device is communicated with a front end piston 6 of the propelling device to form a closed cylindrical inner cavity, and an accommodating box 5 with the inner diameter smaller than that of the storage device is arranged in the cylindrical inner cavity. In order to ensure the sealing performance of the accommodating box and ensure the service life of the accommodating box and the partition plate 7, a layer of sealing ring is arranged on the contact side of the partition plate and the cylindrical inner cavity of the accommodating box, so that the wear resistance of the accommodating box is improved.

The feed screw nut piece comprises a feed screw piece 9 and a nut body 8, the nut body is fixedly connected with the central rod 10, the feed screw piece 9 is rotatably connected with a threaded groove of the nut body 8, one end of the feed screw piece far away from the central rod 10 is far away, and the feed screw piece 9 penetrates through the cylindrical inner cavity to be fixedly connected with the piston 6. The central rod 10 and the nut body 8 rotate to drive the screw rod piece 9 to move up and down, and the piston 6 slides to achieve the reciprocating motion effect. Rubber gaskets are arranged between the external protective housing 13 and the propelling device. A micro motor 12 in the propulsion device is fixedly provided with an electromagnetic coil rack, and the coil rack is provided with a bearing 11 connected with a motor cavity. The tail wing of the propelling device is provided with a button cell 14, and the position of the button cell 14 corresponds to the position of the micro motor bearing 11.

In the embodiment, the storage device is suitable for pre-loading the required dosage of medicine into the accommodating box 5, the accommodating box 5 is in a semi-cylindrical shape, an extrusion space is reserved between the accommodating box 5 and the piston 6, in the storage device, the piston 6 moves forwards to perform injection, and the accommodating box 5 generates volume change; the baffle 7 is arranged at the joint of the cylindrical inner cavity and the propelling device, the change of the action volume of the cavity of the accommodating box is realized, and the accommodating box is prevented from moving up and down due to the extrusion effect of the cylindrical inner cavity of the accommodating box and the baffle.

Before using the injector, the containing box 5 containing the medicine is pre-loaded into the cylindrical inner cavity of the storage device, and is buckled and screwed, and the storage device is butted with the front section of the screw-nut mechanism through the piston 6. The propulsion device is started, the micro motor is started in the forward direction, the electromagnetic coil is electrified to generate a forward rotating magnetic field, the central rod 10 drives the nut body 8 to rotate in the forward direction, in the forward rotating process, the nut body 8 transmits rotation to the screw rod piece 9 to drive the screw rod piece 9 to translate downwards relative to the nut body 8, a piston fixedly assembled with the screw rod piece 9 downwards compresses the medicine in the cylindrical accommodating cavity, the medicine is discharged from the storage device and enters the injection device, the medicine is injected into the cutter head 1 through the injection device under the extrusion of the propulsion device and the gravity action of the medicine, and when the propulsion device continues to advance along the injection direction, the medicine enters human eyes; every time the micro motor 12 rotates forwards, the piston 6 moves downwards once, the fixed amount of medicine is conveyed to the operation position, the function of the injector is realized, the function of stable driving effect of the micro motor is fully utilized, the manufacturing cost is low, and the consistency of the inlet and outlet amount is high.

Before performing an operation, the micro motor 12 is operated firstly, the screw rod piece 9 and the piston 6 are pushed to move forwards by a small section to form, the medicine is injected into the injection device through the storage device so as to lubricate the inner cavity, when the operation is performed, the micro motor 12 is started again, the propulsion device is continuously operated, and therefore the medicine is smoothly injected into human eyes. Note that during surgery, the bolus should not be given too quickly to avoid drug shock.

Compared with the injector used for delivering the medicine in the cataract operation in clinic at present, the cutter head incision of the medicine delivery flow-control injector based on the micro motor provided by the invention has a fine operation mechanical head part, and the cutter head at the front end is designed into a groove for placing the medicine, so that the injector is beneficial to safely passing through a small incision of the anterior chamber, is convenient to get in and out of an operation part, and avoids damaging adjacent tissues.

The injection device adopts a wet etching process, and the pre-etched tool bit made of silicon materials is placed in a hydrofluoric acid HF liquid environment, so that the injection device has the advantage of high reaction efficiency and is suitable for mass production.

The design of the external protective cover shell of the invention considers the use habit of a doctor and the hand man-machine theory in the operation process, so as to better perform the operation. And the button cell is adopted, so that the operation is convenient and quick.

The injection device is pushed by the micro motor and the screw rod nut mechanism, so that the medicine can be injected quantitatively and stably, the stability of the injection device in the injection moving process is ensured, the safety of the operation is improved, the adjusting performance is high, the pushing device is not in direct contact with the medicine, and the inhibitor is not easy to generate secondary pollution.

The above description is only for the purpose of illustrating the technical solutions of the present invention and not for the purpose of limiting the same, and other modifications or equivalent substitutions made by those skilled in the art to the technical solutions of the present invention should be covered by the claims of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims

1. A flow control syringe for drug delivery, characterized in that: comprises an injection device for delivering the medicine, a storage device for containing the medicine, and a propulsion device for pushing the medicine to a required position;

the injection device is divided into a tool bit, a tip, a fine needle and a needle tube; the storage device is communicated with a piston at the front end of the propelling device and enclosed into a closed cylindrical accommodating cavity, and an accommodating box with the inner diameter smaller than that of the storage device is arranged in an inner cavity of the cylindrical accommodating cavity; the propelling device comprises a micro motor, an external protective housing, a screw rod piece, a nut body and a piston, wherein the micro motor is arranged at the tail part of the external protective housing;

2. The drug delivery flow-control syringe of claim 1, wherein: the cross section of the cutter head in the injection device is in a fan-shaped shovel shape and is positioned at the front end of the injection device, arc-shaped outlet connectors are symmetrically obliquely cut out of the outer side of the tip, and one side connector of the tip is fixedly assembled with the cutter head for transition.

3. The drug delivery flow-control syringe of claim 2, wherein: the injection device utilizes a wet etching process, the pre-etched cutter head made of silicon materials is placed in a liquid environment filled with reagents for reaction, the cross section of the cutter head protected by the resist is not corroded, and the etching section is arc-shaped, so that the process requirement of smoothness and stability of the cutter head is met.

4. The drug delivery flow-control syringe of claim 1, wherein: the tool bit, the tip, the fine needle and the needle tube of the injection device adopt an injection molding integral forming process, and the aperture of each section is gradually increased.

5. The drug delivery flow-control syringe of claim 1, wherein: the accommodating box is a semi-cylindrical bin and is driven by the piston to generate volume change; a partition plate is arranged at the joint of the cylindrical inner cavity and the propelling device to prevent the accommodating box from moving up and down with residual medicine.

6. The drug delivery flow-control syringe of claim 1, wherein: the top end of the accommodating box is open, a circular groove is formed in the inner side of the partition plate, the outer side of the partition plate is wrapped by the sealing ring, the partition plate is placed in the radial direction and slides upwards and downwards along the axis to cover the surface of the medicine.

7. The drug delivery flow-control syringe of claim 1, wherein: the screw rod nut piece in the propelling device comprises a screw rod piece and a nut body, the nut body is fixedly connected with the central rod, the screw rod piece is rotatably connected with the threaded groove of the nut body and is far away from one end of the central rod, and the screw rod piece penetrates through the cylindrical inner cavity and is fixedly connected with the piston.

8. The drug delivery flow-control syringe of claim 5, wherein: the central rod and the nut body rotate to drive the screw rod piece to move up and down, and the piston slides to achieve the reciprocating motion effect.

9. The drug delivery flow-control syringe of claim 5, wherein: the outer protective housing is loaded outside the propelling device, and rubber gaskets are arranged between the outer protective housing and the propelling device; a miniature motor in a propelling device for propelling medicine delivery is fixedly provided with an electromagnetic coil rack, and the coil rack is provided with a bearing and connected with a motor cavity.

10. The drug delivery flow-control syringe of claim 1, wherein: the tail wing of the propelling device is provided with a button cell, and the position of the button cell corresponds to the position of the bearing of the micro motor.