CN112137588B

CN112137588B - Comprehensive wound surface management system and method

Info

Publication number: CN112137588B
Application number: CN202011034866.6A
Authority: CN
Inventors: 王晨霞
Original assignee: GANSU PROVINCIAL HOSPITAL
Current assignee: GANSU PROVINCIAL HOSPITAL
Priority date: 2020-09-27
Filing date: 2020-09-27
Publication date: 2023-05-23
Anticipated expiration: 2040-09-27
Also published as: CN112137588A

Abstract

The invention relates to a comprehensive wound management system, which at least comprises a wound scanning module, a central processing unit and a patch pump, wherein before the central processing unit responds to an operation instruction of medical care to transmit a medicine scheme to the patch pump, the central processing unit determines the relation between the current wound information of a patient and the expected local physiological data fluctuation value of the wound in a preset time period after the expected medicine is injected in the medicine scheme based on the historical data of the patient in a mode that the historical insulin injection data is related to the physiological data, and utilizes a physiological information analysis module to simulate the physiological data of the wound scanning module and/or the patch pump, which is at least related to the blood sugar of the patient, expected to appear after the physiological data is negatively related to the local physiological data fluctuation value, and at least one medicine scheme is generated according to the simulated local post-injection physiological data.

Description

Comprehensive wound surface management system and method

Technical Field

The invention relates to the technical field of medical equipment, in particular to a comprehensive wound surface management system and method.

Background

For a long time, clinicians have been searching for a simple, efficient and accurate calculation method for wound surface area and volume. Since the last century, researchers have formed methods of burn area calculation based on "Rules of mines" and "Lund-browser forms" through a number of clinical practices and scientific analyses. The two methods are convenient, quick and relatively accurate, have great significance for wound surface sealing during the process of grasping the injury and recovering the liquid in the shock period, but have certain defects because the two methods are both estimation. These methods are simple estimations of wounds and are greatly affected by subjective factors, so that different physician estimations may differ. Leading clinicians to draw different conclusions when using these methods to formulate therapeutic strategies or rehydrate, and not to form a unified standard and consensus.

Many new measuring methods have been proposed in clinical and scientific work. With the development of 3D technology, various lesions can be subjected to 3D printing and copying, and a wound surface three-dimensional measuring instrument is generated. For example, eKare insight wound surface management system and matched equipment developed by e-Kare Inc. company, eKare insight mainly adopts low-energy infrared signals to obtain the 3D Structure of wound surface, and simultaneously matched apple ipad and Structure Sensor are operated. The eKare weight not only can perform three-dimensional size measurement on a wound surface, but also can perform image archiving, clinical recording and patient management. The basic principle of the eKare light system measuring instrument uses a structural 3D photosensitive technology, namely, during detection, structural light is firstly emitted to the whole detected space through an infrared emitter, any position in the space can be marked by a structural light source, after the whole space is marked, a 3D structural light sensor can identify the specific position of a tracked target in a three-dimensional space, and then required data are calculated according to different photoelectric codes. Compared with the prior digital camera shooting, the device can measure two-dimensional data such as area and the like and can measure three-dimensional space so as to measure the depth and volume of the wound surface.

As another example, a mobile three-dimensional wound scanning device and a workflow thereof proposed in the prior art publication No. CN109700465a, including a depth camera, a telescopic link, a delineating device for drawing an area on a mobile terminal, the depth camera is mounted on the rear side of the telescopic link, the mobile terminal can be detachably clamped on the front side of the telescopic link, and the camera of the mobile terminal faces backwards, and the delineating device is detachably mounted on the telescopic link. The workflow of the mobile three-dimensional wound scanning device comprises the following steps: 1) The mobile terminal is clamped on the telescopic connecting frame, and the depth camera arranged on the telescopic connecting frame is in data butt joint with the mobile terminal; 2) Enabling a camera of the mobile terminal and a depth camera to face towards the wound, automatically acquiring a color image of the wound by the camera, and automatically acquiring a depth image of the wound by the depth camera; 3) The method comprises the steps of correcting distortion of an image and obtaining position parameters of the camera through three-dimensional calibration of the camera, and realizing alignment of a color image and a depth image by utilizing the position parameters of the camera; 4) Manually drawing the ROI on the mobile terminal by a user through a delineating device, enabling the mobile terminal to identify the accurate position of the wound in the ROI, automatically analyzing the characteristics of the wound, carrying out three-dimensional reconstruction on the wound, calculating depth information and volume information of the wound, and analyzing tissue components of the wound; 5) And the mobile terminal automatically realizes the display and uploading of the wound image and the measurement data to the server. The mobile terminal and the three-dimensional wound scanning equipment are installed together, so that wound assessment indexes such as the area, the volume, the depth, the length and the width of a wound can be measured efficiently, accurately and conveniently, and wound assessment information of a patient can be recorded. The three-dimensional wound scanning device has low requirements on the manipulation and experience of operators, and the measurement mode of the three-dimensional wound scanning device is non-contact, does not need to invade a wound, and cannot cause secondary injury to the wound.

However, the above-mentioned wound care auxiliary devices that have been proposed all rely on the measurement capability of the 3D photosensitive technology, and are limited to provide the wound measurement function, which has certain drawbacks. The defects are that: on one hand, the current 3D photosensitive technology has limited measurement capability, and a wound cavity of a visual measuring instrument (such as 3D photosensitive equipment) which is difficult to be used under the skin cannot be observed, so that a measurement result error is larger; on the other hand, especially for DFUs patients with relatively high ratio among chronic wound patients, diabetes mellitus and wound surfaces can be mutually influenced, so that the worsening risk of the two diseases is sharply increased, and the wound surface nursing auxiliary equipment which is proposed at present has single function and can not provide effective nursing auxiliary effect for DFUs patients.

Furthermore, there are differences in one aspect due to understanding to those skilled in the art; on the other hand, as the inventors studied numerous documents and patents while the present invention was made, the text is not limited to details and contents of all that are listed, but it is by no means the present invention does not have these prior art features, the present invention has all the prior art features, and the applicant remains in the background art to which the rights of the related prior art are added.

Disclosure of Invention

The wound nursing auxiliary equipment which is used for the measurement capability depending on the 3D photosensitive technology in the prior art is limited to provide a wound measurement function, and has certain defects. The defects are that: on one hand, the current 3D photosensitive technology has limited measurement capability, and a wound cavity of a visual measuring instrument (such as 3D photosensitive equipment) which is difficult to be used under the skin cannot be observed, so that a measurement result error is larger; on the other hand, especially for DFUs patients with relatively high ratio among chronic wound patients, diabetes mellitus and wound surfaces can be mutually influenced, so that the worsening risk of the two diseases is sharply increased, and the wound surface nursing auxiliary equipment which is proposed at present has single function and can not provide effective nursing auxiliary effect for DFUs patients.

Aiming at the defects of the prior art, the application provides a comprehensive wound surface management system which at least comprises a wound surface scanning module and a central processing unit, wherein the wound surface scanning module is as follows: the device is used for collecting images of wound surfaces of patients according to wound surface measurement instructions from the central processing unit; and the central processing unit: the system is used for sending a wound measurement instruction to the wound scanning module according to the operation instruction of medical care, and establishing a three-dimensional model about the wound based on at least the image data obtained after the treatment of the wound scanning module, and is characterized by further comprising: a patch pump for wearing in the vicinity of a patient's wound and performing a wound drug injection according to a drug regimen from the central processor, and/or indirectly collecting and transmitting, in a non-invasive manner, physiological information relating to at least blood glucose of a patient wearing the patch pump to a central processor pre-paired with the patch pump and having at least a physiological information analysis module, in response to a medical prescription, the central processor determining, based on historical data of the patient, a relationship between current wound information of the patient and an expected local physiological data fluctuation value of the wound within a predetermined period of time after an expected drug injection in the drug regimen, based on the historical data of the patient in a manner wherein the historical insulin injection data is associated with the physiological data, and simulating, with a physiological information analysis module, local post-injection physiological data expected to occur after the local physiological data fluctuation value is negatively associated with the at least blood glucose of the patient from the wound scan module and/or the patch pump, and generating at least one of the drug regimen according to the simulated local post-injection physiological data.

The comprehensive wound surface management system combines the vision measurement capability of the 3D sensitization technology with the accurate drug delivery function of the patch type drug injection pump, can provide a reasonable drug scheme for medical care of chronic wound surface patients such as DFUs patients on the basis of fully considering individual differences of the patients to the drugs such as insulin, and can realize active local drug delivery to the wound surface by using the patch type drug injection pump. The comprehensive wound surface management system in the application can simultaneously give out the expected local post-injection physiological data and the change trend thereof according to the given drug scheme. The comprehensive wound surface management system is particularly suitable for DFUs patients with relatively high occupancy rate in chronic wound surface patients, diabetes mellitus and wound surfaces can be mutually influenced, so that the worsening risk of two diseases is sharply increased, and the system provided by the application not only can monitor local blood sugar and wound surface conditions, but also can provide reasonable medicine schemes for selection, namely, can provide effective nursing auxiliary effects for the DFUs patients. In addition, the vision measurement technology which is not a single 3D sensitization technology any more and is utilized by the application is combined with the existing vision three-dimensional scanning reconstruction technology, so that the wound cavity volume measurement can be very well carried out on the common chronic wound surface similar to the common wound surface with the positive taper. And the blood vessel perspective developing technology is also adopted, and the reliable measurement of deep invisible wound cavities can be realized by combining the blood vessel perspective developing technology with the mature visual three-dimensional scanning reconstruction technology and the perspective three-dimensional scanning reconstruction technology (such as spiral CT detection technology, X-ray coronary angiography (coronary angiography, CAG), intravascular ultrasound (intravascular ultrasound, IVUS), magnetic resonance angiography (magnetic resonance angiography, MRA) and the like), so that the problem that the existing comprehensive wound surface management system is limited by the technical difficulty of the visual three-dimensional scanning reconstruction technology is solved.

According to a preferred embodiment, the central processor generates and provides at least one of the drug regimens created based at least on a wound retest cycle determined by the central processor from physiological information of the wound scan module and/or the patch pump at least related to blood glucose of the patient on a display interface of the central processor and/or a smart device operated by a medical care in at least two different display modes from the simulated local post-injection physiological data.

The drug regimen presented in the present system may be presented to the medical care and/or patient in at least two different display modes. The display mode can comprise data transverse comparison and trend graphs, and can also comprise a three-dimensional model graph and/or a mark graph with a multi-point mark of a wound retest period. The distinct advantages of each drug regimen relative to each other may be manifested from a number of different angles. Meanwhile, the medicine scheme provided by the system comprises a wound retest period, which can be used for indicating proper medicine changing time and/or medicine detachment retest time for medical care. The opportunity can meet the requirement of the dressing change interval corresponding to the current stage of the wound surface, and avoid too frequent or too long dressing change.

According to a preferred embodiment, the system further comprises: the intelligent dressing is used for covering the wound surface of a patient, collecting wound surface information, which is at least related to the wound cavity environment, of the wound surface which is covered with the intelligent dressing and is not open, according to a drug scheme from the central processing unit, and sending the wound surface information to the central processing unit which is paired with the intelligent dressing in advance and is provided with at least a wound cavity environment analysis module, so that at least one drug scheme can be provided to the central processing unit and/or a display interface of intelligent equipment operated by medical care in a display mode that predicted data are compared with actual monitoring data.

The above-mentioned comprehensive wound surface management system that this application provided has combined the vision measurement ability of 3D sensitization technique, has pasted the accurate function of dosing of applying formula medicine syringe pump and intelligent detection function of intelligent dressing, from visual and non-visual, can realize the detection to the wound cavity environment, is favorable to follow-up optimizing medicine scheme to reach better wound surface management effect.

According to a preferred embodiment, the wound surface scanning module at least comprises: the first wound surface scanning module is used for acquiring a first target area image by utilizing first light rays and identifying wound surface information in the first target area image at least based on the first target area image; and/or the second wound surface scanning module is used for acquiring a second target area image by utilizing second light rays, and identifying one or more real-time blood vessel information at least comprising first real-time blood vessel information corresponding to the isolated wound cavity area, second real-time blood vessel information corresponding to the wound cavity extension area and third real-time blood vessel information corresponding to the wound cavity main body area in the second target area image based on the second target area image.

The comprehensive wound surface management system provided at present is often limited in the range of the wound cavity which can be acquired by the visual camera equipment, and is limited in the aspect of height and wound cavity volume measurement by the invisible part of the wound cavity (such as an inverted cone wound cavity with a small mouth and a large bottom), the light rays of the visual camera equipment cannot reach the bottom and the edge, the receiving of distorted light beams is prevented, the measurement dead angle exists, and the wound surface condition cannot be well exposed. In this regard, the evaluation management system provided by the application is not limited by the scope of the visible wound cavity main body any more by means of the vessel perspective imaging technology, but expands the scope to a wider wound cavity extension area and an isolated wound cavity area by updating the target area, and utilizes the characteristics that the wound cavity is difficult to measure, the common depth of the wound cavity is large, and the damage is caused to the blood vessels related to the wound cavity.

According to a preferred embodiment, the central processor further comprises: the first simulation processing module is used for obtaining a second simulation model obtained by carrying out reverse three-dimensional simulation construction on first real-time blood vessel information corresponding to the isolated wound cavity area in combination with the wound surface information identified by the first wound surface scanning module, and a third simulation model obtained by carrying out reverse three-dimensional simulation construction on second real-time blood vessel information corresponding to the wound cavity extension area and third real-time blood vessel information corresponding to the wound cavity main body area in combination with the wound surface information identified by the first wound surface scanning module, and generating a first simulation model for evaluating chronic wound surfaces by utilizing the second simulation model and the third simulation model.

According to a preferred embodiment, the system further comprises: the recording device is used for collecting wound surface information recorded in a non-image processing mode; and/or a target area updating module, configured to, when the first wound surface scanning module processes the first target area image to obtain a wound cavity main area, perform area prediction in combination with the wound cavity main area and the wound surface information that is at least obtained by the input device and the first wound surface scanning module respectively, so as to obtain a wound cavity extension area that is adjacent to the wound cavity main area and cannot be identified by the first wound surface scanning module from the skin surface layer, and an isolated wound cavity area that is adjacent to the wound cavity extension area and at least does not identify a wound surface from the skin surface layer by the first wound surface scanning module, and update the first target area based on the wound cavity extension area to obtain a second target area that at least includes the isolated wound cavity area, the wound cavity extension area and the wound cavity main area.

According to a preferred embodiment, the target area updating module processes based on the wound cavity main area obtained by the first wound surface scanning module after processing the first target area image and at least includes wound surface information obtained by the first wound surface scanning module according to a first projection rule and an input device, so as to obtain a second target area which is required by the second simulation model and the third simulation model for performing space-time interactive reverse verification updating and at least includes an isolated wound cavity area, a wound cavity extension area and a wound cavity main area, so that the first simulation processing module can generate a first simulation model based on the second target area by performing space-time interactive reverse verification updating on the second simulation model and the third simulation model.

The application also provides a comprehensive wound surface management method, which is characterized by at least comprising one or more of the following steps: image acquisition is carried out on the wound surface of the patient according to the wound surface measurement instruction from the central processing unit; sending a wound measurement instruction to the wound scanning module according to the operation instruction of medical care, and establishing a three-dimensional model about the wound based on at least image data obtained after the treatment of the wound scanning module; determining a relationship between current wound information of the patient and expected local physiological data fluctuation values of the wound within a predetermined period of time after an expected drug injection in the drug regimen based on historical data of the patient in a manner in which the historical insulin injection data is correlated with the physiological data; simulating local post-injection physiological data that is expected to occur after at least physiological information related to a patient's blood glucose is negatively correlated by the local physiological data fluctuation value; generating at least one of the drug regimens from the simulated local post-injection physiological data; transmitting a medication regimen to the patch pump in response to an indication of the operation of the medical care; and instructing the patch pump to perform wound medicine injection according to the medicine scheme.

According to a preferred embodiment, the method further comprises the steps of: at least one of the drug regimens created based at least on a wound retest cycle determined by the central processor from physiological information related at least to the patient's blood glucose is generated from the simulated local post-injection physiological data and provided in at least two different display modes on a display interface of the central processor and/or a smart device operated by a medical care.

According to a preferred embodiment, the method further comprises the steps of: acquiring a first target area image by using first light rays, and identifying wound surface information in the first target area image at least based on the first target area image; and/or acquiring a second target area image by utilizing the second light ray, and identifying one or more real-time blood vessel information at least comprising first real-time blood vessel information corresponding to the isolated wound cavity area, second real-time blood vessel information corresponding to the wound cavity extension area and third real-time blood vessel information corresponding to the wound cavity main body area in the second target area image based on the second target area image.

Drawings

FIG. 1 is a simplified schematic diagram of the module connection relationship of the integrated wound management system of embodiment 1 provided by the present invention;

FIG. 2 is a simplified schematic diagram of the module connection relationship of the integrated wound management system of embodiment 2 provided by the present invention;

FIG. 3 is a simplified flow chart of the steps of the method for integrated wound management of embodiment 3 provided by the present invention;

fig. 4 is a simplified schematic diagram of a preferred isolated wound cavity region, wound cavity extension region and wound cavity body region versus wound surface provided by the present invention.

Detailed Description

The integrated wound management system and method provided by the application will be described below with reference to embodiments of the application and accompanying drawings. It should be understood that the embodiments described in this application are only some, but not all, of the embodiments of this application. Furthermore, references in the present application to terms such as "comprising" and "includes" are to be interpreted as specifying the presence of the stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof. The term "and/or" as referred to in this application may be interpreted as indicating any and all possible combinations of one or more of the associated listed items, and include such combinations.

Related concepts and terms referred to in this application are set forth below for the understanding of those skilled in the art.

DFUs, diabetic Foot Ulcers, diabetic foot ulcers, or diabetic lower limb ulcers. DFUs are serious complications often caused by diabetes mellitus, and belong to chronic incurable wounds. DFUs are ulcers, infections and deep tissue destruction of the foot associated with local nerve abnormalities in the patient and lesions in peripheral blood vessels at the distal end of the lower limb, and severe cases may even involve bones, joints, etc. Once DFUs are formed, the risk of wound deterioration increases further, which in extreme cases can lead to severe necrosis.

The wound surface is mainly a chronic wound surface, and can be divided into an acute wound surface and a chronic wound surface according to the healing period of the wound surface. Acute wound is a wound which is formed from the first two weeks of the wound, and then, the wound is partially or completely stopped due to the blocking of the wound healing process caused by certain adverse influencing factors such as infection, foreign matters and the like, so that the wound healing time exceeds two weeks, and the wound is called chronic wound.

Patch pumps, also known as patch insulin pumps. The insulin pump mainly comprises a pump, a small injector and a transfusion tube connected with the small injector. The patch type insulin pump has smaller volume and is provided with a sensor head, can be closely attached to the skin surface of a patient to monitor the blood sugar fluctuation, and stores 200 units of insulin in the machine. The pump can automatically select 1 part, 0.1 part, 0.5 part or 1.5 parts of different dosage dosing schemes according to the blood sugar condition of a patient. The small injector can contain 3 milliliters of insulin at most, after the injector is filled into the pump, the spiral motor of the battery-driven insulin pump pushes the piston of the small injector, the insulin is infused into the insulin pump in the body, the basic purpose of the insulin pump is to simulate the secretion function of pancreas, the insulin is continuously infused into the subcutaneous of a patient according to the dosage required by the patient, and the blood sugar is kept stable throughout the day, so that the aim of controlling diabetes is fulfilled.

A drug regimen is herein primarily meant to include at least one or several parameter sets of drug variety, drug dosage, time of administration, rate of administration, interval of administration for administration. The drug variety can comprise one or more of ultra-short-acting insulin (analogues), short-acting insulin, medium-acting insulin and premixed insulin. The ultra-short acting insulin (analog) may include insulin aspart, ultra-long acting insulin (analog) and/or insulin lispro. Short-acting insulin can be classified into animal-derived short-acting insulin and recombinant human-derived short-acting insulin. The medium-acting insulin may be norand N. The ultra-long acting insulin (analogue) may include one or more of insulin glargine, insulin detention, insulin deglutition. The pre-mixed insulin may be a mixture of short-acting or ultra-short acting insulin and one or more of medium-acting or long-acting insulin. It should be understood that the drugs mentioned in this application may include, but are not limited to, mixtures of one or more of the above-mentioned insulins.

The intelligent dressing can be a composite dressing formed by embedding a monitoring device for monitoring one or more of wound temperature, humidity, pH value, oxygen content, NO concentration, microorganisms and environmental pressure of the wound into the dressing. The intelligent dressing can be used for monitoring wound surface information of a patient in real time, and long-term storage, sharing and monitoring of various wound surface data information are realized through a background service platform. The intelligent dressing can provide wound surface information under the condition that dressing change is not needed, and the wound surface healing condition is obtained.

The present application will be described in detail with reference to examples and drawings.

Example 1

As shown in fig. 1, this embodiment proposes an integrated wound management system. The comprehensive wound surface management system mainly comprises a patch pump, a central processing unit and a wound surface scanning module.

Description is made for a patch pump in the present application: the patch pump is stably covered on the adjacent part of the wound surface in the using process. The patch pump can be used for monitoring blood glucose data of a local part where a wound surface is located. The patch pump can be preloaded with medicines and can be used for actively administering medicines to the local part where the wound surface is located. Among the drugs mentioned here, at least insulin drugs which are beneficial for wound healing are included. Healing of a diabetic patient's wound may stagnate at one or more stages of the healing process, resulting in the wound gradually transitioning to a chronic, non-healing wound surface. Hyperglycemia itself is an initial change in the circulatory system of diabetes, however, the persistence of a high sugar environment can hinder the healing process of diabetic wounds, not only inhibit vascular repair, but also hinder the neogenesis process of blood vessels, and destroy already-regenerated blood vessels. In contrast, the cell and molecular mechanisms of the insulin on wound healing proposed by a large number of related researches indicate that the application of insulin can reduce inflammatory response, accelerate cell proliferation and migration, fibrous collagen deposition and re-epithelialization, promote processes of tissue granulation, blood vessel regeneration, wound contraction and the like, and promote wound healing under the condition of diabetes. Therefore, the application adopts the form of an applied insulin pump to administer for a long time, and can achieve better wound healing effect.

In some embodiments, the patch pump may perform wound drug injection according to a drug regimen from the central processor. The patch pump may indirectly collect physiological information in a non-invasive manner in response to wound measurement instructions (including at least a medication regimen) from the central processor. The physiological information here is at least related to blood glucose. The physiological information may here reflect at least part of the physiological condition of the patient wearing the patch pump. The patch pump may be pre-paired with the central processor. The patch pump may send the physiological information to a designated central processor for processing. The physiological information collected by the patch pump may include one or more of blood oxygen data, blood glucose data, and heart rate data.

The description is made for the central processing unit in the present application: in some embodiments, the central processor may be a smart home device, a wearable device, a smart mobile terminal, a virtual reality device, an augmented reality device, or the like, or any combination of the above examples. In some embodiments, the smart mobile terminal is one or several of a smart phone, a notebook, a tablet reader, a wearable device, for example. The wearable device may be a smart watch, smart wristband, smart glasses, smart helmet, smart mask, smart footwear, smart clothing, smart backpack, smart accessory, or the like, or any combination of the above examples. In some embodiments, the smart home devices may include smart lighting devices, control devices for smart appliances, smart monitoring devices, smart televisions, smart cameras, interphones, and the like, or any combination of the above examples. In some embodiments, the smart mobile device may include a mobile phone, a personal digital assistant, a gaming device, a navigation device, a POS, a laptop, a desktop, or the like, or any combination of the above examples. In some embodiments, the virtual reality device and/or the augmented reality device may include a virtual reality helmet, virtual reality glasses, virtual reality eyecup, augmented reality helmet, augmented reality glasses, augmented reality eyecup, or the like, or any combination of the above examples.

In some embodiments, the central processor may be a single server or a group of servers. The server farm may be centralized or distributed (e.g., the central processor may be a distributed system). In some embodiments, the central processor may be local or remote. For example, the central processor may access information and/or data in the wound scanning module and/or database via a network. For another example, the central processor may be directly connected to the wound scanning module and/or database to access information and/or data therein. In some embodiments, the central processor may be implemented on a cloud-side device. For example only, cloud-side devices may include private clouds, public clouds, hybrid clouds, community clouds, distributed clouds, cross-clouds, multi-clouds, and the like, or any combination of the above. In some embodiments, the central processor may be implemented on a computing device, which may include one or more components.

It should be understood that the embodiments presented herein are illustrative only and that the apparatus disclosed herein may be implemented in other ways. For example, the division of units/modules/devices/apparatuses described in this application is merely a logic function division, and may be implemented in other manners. For example, multiple units, modules, or components may be combined, or may be integrated into another system, or some features may be omitted or not performed.

In some embodiments, the central processor may comprise a processing device. The processing device may process information and/or data related to physiological information and/or drug regimens to perform one or more functions described herein. For example, the processing device may obtain physiological information at least related to blood glucose of the patient from the wound surface scanning module and/or the patch pump, and send the processed data to the display interface of the central processing unit and/or the display interface of the terminal operated by the medical care and/or the wound surface scanning module and/or the patch pump through the network. Or for example, the processing device generates from the simulated local post-injection physiological data and provides at least one of the drug regimens created based at least on a wound retest cycle determined by the central processor from physiological information related at least to the patient's blood glucose by the wound scanning module and/or the patch pump on a display interface of the central processor and/or a terminal operated by the medical care in at least two different display modes. In some embodiments, a physiological information analysis module and a luminal environment analysis module may be included in the central processor. In some embodiments, the processing device may process information and/or data related to the three-dimensional model processing content to perform one or more functions described herein. For example, the processing device may acquire image data and/or related information about the wound surface from the wound surface scanning module, send the processed data to the intelligent device and/or cloud side device operated by the user through the network, or acquire information and/or data related to the processing content of the three-dimensional model from the cloud side device, and send the information and/or data to the wound surface scanning module. In some embodiments, the central processor may include at least one three-dimensional model processing module therein. The three-dimensional model processing module may include a second analog processing module, a third analog processing module, and a first analog processing module. The wound surface scanning module can comprise a first wound surface scanning module and a second wound surface scanning module. In some embodiments, the processing device may include one or more processing engines (e.g., a single-chip central processing unit or a multi-chip central processing unit). By way of example only, the processing device may include one or more hardware central processing units, such as a Central Processing Unit (CPU), an Application Specific Integrated Circuit (ASIC), a special instruction set central processing unit (ASIP), or the like, or any combination of the above.

In some embodiments, a database may be provided in each of the patch pump, the central processor, the wound scanning module, and the cloud-side device, and the database may be used to store data and/or instructions. In some embodiments, the database may store data processed or entered by the patch pump, central processor, wound scan module, and cloud-side device. In some embodiments, the database may store data and/or instructions for execution or use by one or more of a patch pump, a central processor, a wound scanning module, and a cloud-side device, which may be executed or used by a server to implement the exemplary methods described herein. In some embodiments, the database may include mass storage, removable storage, volatile read-write memory, read-only memory (ROM), and the like, or any combination of the above. Exemplary volatile read-only memory can include Random Access Memory (RAM). Exemplary random access memory may include Dynamic Random Access Memory (DRAM), double rate synchronous dynamic random access memory (ddr sdram), and the like.

In some embodiments, the central processor may derive at least one medication regimen based on the collected physiological information, the medication regimen being indicative of the operation of the patch pump. The central processing unit can call the historical data of the patient from the cloud side equipment through the network. The patient's historical data may refer primarily to a large number of historical insulin injection records stored in a cloud-side device or medical system due to the diabetes patient's own blood glucose control needs. The patient's historical data may be changes over time in physiological data detected by the patient under a defined insulin injection regimen during a previous insulin injection. That is, the correlation between the historical insulin injection data and the physiological data can be processed and obtained by the historical data. For example, insulin of a predetermined variety is injected into a patient at predetermined single doses at injection intervals based on the patient's own current physiological data, and changes in the patient's physiological data over time are continuously monitored.

In some embodiments, the historical data of the patient may be historical data of other patients from other central processors, which are obtained by matching the central processor at the cloud-side device, based on patient information and/or wound surface information of the current patient.

In some embodiments, the central processor may process to obtain a set of insulin sensitivity factors for the patient. The central processing unit can process and obtain an insulin sensitivity factor set based on the historical data. The set of insulin sensitivity factors may include at least a subset. The set of insulin sensitivity factors may refer to a set of different degrees of sensitivity and variations of the patient to different insulin injection data under different current physiological data. Preferably, the set of insulin sensitivity factors may be expressed in a functional manner:

in the method, in the process of the invention,

the insulin sensitivity coefficient can be used to represent a certain physiolog (physiological characteristic) for the ith i _Isulin Sensitivity (input variable, or insulin injection parameter). X'. _Physiology Can be used to indicate that the patient is suffering from the ith i _Isulin The physiological data after the perturbation (input variable, or insulin injection parameter) changes by an expected value. X is X _Physiology Can be used to represent the current physiological data of the patient entered when the function was constructed. Wherein, when- >

The larger the value, the more a certain physiolog can be expressed for the ith i _Isulin The higher the sensitivity of (2).

In some embodiments, the central processor may determine a relationship between the patient's current wound information and an expected local physiological data fluctuation value. That is, in the case of a patient's current wound information determination, a set of expected local physiological data fluctuation values corresponding thereto may be generated. The set of expected local physiological data fluctuation values may be derived based on a set of insulin sensitivity factors for the patient. For the management of different types of wounds and/or different severity levels of wounds, at least three different common dosing regimens are pre-stored in the central processor, each dosing regimen comprising a combination of i with i _Isulin Corresponding reference data. Based on the different insulin sensitivity factor sets of different patients, the administration regimen given with each i can be combined _Isulin Corresponding reference data are processed, for example by means of weighting calculations, to obtain expected local physiological data fluctuation values corresponding to different dosing regimens for the patient. The expected local physiological data fluctuation value can be a quantized value obtained by predicting the degree to which physiological data is affected after drug injection for the local position of the wound surface before insulin administration.

In some embodiments, the central processor may determine post-local injection physiological data, which may be used to represent expected values of physiological data expected to occur after administration of a drug regimen. The central processing unit may utilize: the physiological information analysis module simulates the situation of the patient after insulin administration, namely, the current physiological information of the patient is simulated under the situation that the local physiological data fluctuation value is negatively correlated. The physiological information may include physiological information from the wound scanning module that is related to at least the wound measurement data. The physiological information may also include physiological information of the patch pump related to at least blood glucose of the patient. Negative correlation of the two may mean that there is the same computational unit between one and the other that is capable of doing the computation, and that one negatively affects the other. A "patient" may be understood in this application as a "patient wound". For example, the current physiological information of the wound surface of the patient is negatively associated with the local physiological data fluctuation value, that is, the current physiological information of the wound surface of the patient is subtracted from the local physiological data fluctuation value, so that the expected local post-injection physiological data of the wound surface which appears in a preset time period after insulin administration can be obtained.

In some embodiments, the central processor is capable of generating at least one of the drug regimens from the simulated local post-injection physiological data. The drug regimen is derived taking into account the patient's insulin sensitivity factor set. Physiological data at least related to blood sugar of a local part of a wound surface of a patient can be well controlled, and the blood flow capacity, the angiogenesis capacity, the vascular repair capacity and the like of the local part can be effectively improved.

In some embodiments, the central processor may process to obtain a wound retest cycle that is used to indicate a proper dressing change time and/or timing of a drug removal retest for medical care. Retesting can refer to image acquisition of the wound surface by using the wound surface scanning module after removing the dressing on the wound surface, and/or visual inspection of wound surface change by medical care. Based on the determined wound retest period, the central processor may generate at least one medication regimen. Each of the drug regimens includes a predetermined administration period or interval, and the central processor may set the wound retest period based on one or more of the administration periods or intervals. The wound retest period should be limited by the range of dressing change interval durations corresponding to the current healing stage of the patient's wound.

In some embodiments, the central processor provides the resulting medication regimen to a display interface of the central processor and/or a smart device operated by the medical care in at least two different display modes. The display means may be means for displaying the resulting medication regimen to the medical care and/or patient by means of data visualization. For example, the display mode at least comprises a plurality of drug regimen table formats and a transverse comparison display mode, and/or a trend graph of expected local post-injection physiological data corresponding to a single drug regimen over time, and/or a trend graph of expected local physiological data fluctuation values corresponding to a single drug regimen over time, and/or a three-dimensional model graph of expected wound healing process corresponding to a single drug regimen, and/or a trend graph of expected local post-injection physiological data corresponding to a single drug regimen over time with multi-point identification of wound retesting period.

In some embodiments, the wound scanning module provided in the present application is used as an independent component, and can be connected to the tablet computer wirelessly or by wire. The wound scanning module can be provided with a base and a rotatable accessory. The base may be configured to support the wound scanning module relatively stably secured to a table or bed surface, and the rotatable accessory may be configured to support the wound scanning module to adjust its relative position or relative angle with respect to the base. That is, the wound surface scanning module can be assembled on a table surface or a bed surface, and can actively adjust the multi-position parameters such as the height, the position, the angle and the like of the wound surface scanning module on a base so that the wound surface scanning module can acquire images according to the indicated projection rules.

The first wound surface scanning module can be configured to acquire a target area image by using first light rays according to a first projection rule, and based on the first light rays, at least the wound surface information in the target area image can be identified, wherein the wound surface information at least comprises a wound cavity main body area and/or a part of a visible wound cavity.

The projection rule mentioned in the present application may be a motion path for indicating the image acquisition end of the first and second wound scanning modules. The first projection rule mentioned in the application may be a motion path for indicating that the image acquisition end of the first wound scanning module needs to rotate around the wound at least at multiple angles for acquisition. The second projection rule mentioned in the application may be a motion path for indicating that the image acquisition end of the second wound scanning module needs to move back and forth along the length direction of the limb where the wound is located.

The first light ray and the second light ray mentioned in the present application are relative to each other. The first light ray mentioned in the application may be an infrared light ray with smaller human body absorbability supporting the first wound scanning module to collect the wound profile on the inner wall of the wound cavity and/or the skin surface. The wavelength band of the first light is shorter than the wavelength band of the second light. The second light ray mentioned in the application can be the infrared light ray that the human blood absorption degree of supporting second surface of a wound scanning module to gather the blood vessel form that goes deep into skin inside is better. The first light and the second light may originate from different light sources or may originate from the same light source. In case the first light and the second light originate from the same light emitting source, the light emitting source may emit infrared light having a continuous wavelength.

The second wound scanning module may be configured to acquire an updated target region image with a second light using a second projection rule, based on which at least first real-time blood vessel information in the isolated wound cavity region image and/or second real-time blood vessel information in the wound cavity extension region and/or third real-time blood vessel information in the wound cavity main body region may be identified. The updated target area is determined by the target area updating module. The target region updating module may be configured to predictably derive a wound cavity extension region adjacent to the wound cavity body region that is unrecognizable from the skin surface by the first wound scan module and an isolated wound cavity region based on the wound cavity body region and wound information provided by the patient, and to update the target region based on the isolated wound cavity region, the wound cavity extension region, and the wound cavity body region.

The third simulation processing module may be configured to derive a third simulation model indicative of local vessel morphology in the pre-traumatic target region via reverse three-dimensional simulation construction based on the second real-time vessel information, the third real-time vessel information, and the wound information provided by the patient. The reverse three-dimensional simulation construction proposed by the present application may refer to reverse-predicting a simulation model in which data modeling is not acquired in the past period of time, based on a basic model in which data modeling can be acquired directly and reverse three-dimensional simulation construction parameters.

The second simulation processing module may be configured to derive a second simulation model to simulate a vessel morphology at a pre-traumatic target region via a reverse three-dimensional simulation construction based on the first real-time vessel information and the wound information provided by the patient. The second simulation processing module is further configured to perform reverse verification on the second simulation model according to the continuous blood vessel model determined in the third simulation model and the spatial layer label corresponding to the continuous blood vessel model, so as to obtain a verified and updated second simulation model. The space layer is processed by a fourth analog processing module. The fourth simulation processing module may be configured to spatially cut the updated second simulation model based on one or more of the first to third real-time blood vessel information to obtain a plurality of spatial layers located at different depths of the skin. The fourth simulation processing module can respectively carry out space layer labeling on the second simulation model and the third simulation model. The fourth simulation processing module can perform space cutting on the second simulation model at least according to the determined discontinuous blood vessel model and the corresponding space layer label in the third simulation model, and divide the second simulation model to obtain a missing part simulation model for roughly outlining the internal form of the wound cavity.

The time-space interactive reverse verification update referred to in the present application may refer to a process of further verifying and updating the second analog processing module obtained by processing the second analog processing module by using the fourth analog processing module and the third analog processing module. The time-space in the time-space interactive reverse verification update mainly refers to time scale features and space layer labels. The time scale feature mentioned in the present application may refer to a time zone before injury, and the time scale feature is mainly used for unifying whether two models to be spatially interacted belong to the same time zone, i.e. whether the two models can spatially interacted. Reference in this application to spatial layer labeling may refer to depth data at different depths from the skin, spatial layer labeling being primarily used to match two three-dimensional models in a spatial coordinate system such that the two interact with each other in the spatial coordinate system. The reverse verification update in the space-time interactive reverse verification update mainly refers to verification and adjustment update of at least one three-dimensional model by using two three-dimensional models which are all constructed through reverse three-dimensional simulation.

The fourth simulation processing module can perform space interaction on the verified updated second simulation model and the third simulation model at least comprising a discontinuous blood vessel model based on space layer labeling so as to divide and obtain a missing part simulation model for initially describing the internal form of the wound cavity, and the first simulation processing module can perform further boundary processing on the missing part simulation model based on the wound surface information at least comprising the input equipment and the first wound surface scanning module respectively so as to update the missing part simulation model.

The first simulation processing module may be configured to perform boundary processing on the missing part simulation model according to the wound information acquired by the first wound scanning module and the wound information provided by the patient, so as to obtain a missing part simulation model which is updated in a processing manner and is used for indicating the fine outlining of the internal form of the wound cavity.

It is to be appreciated that references in the present application to "this embodiment" and/or "in some embodiments" etc. mean a particular feature, structure, or characteristic associated with at least one embodiment of the present application. Certain features, structures, or characteristics of one or more embodiments of the present application may be combined as suitable.

Example 2

As shown in fig. 2, this embodiment proposes an integrated wound management system. This embodiment may be a further improvement and/or addition to embodiment 1, and the repeated description is omitted. In addition to this embodiment, the preferred implementation of the other embodiment may be provided in whole and/or in part without conflict or contradiction. The integrated wound management system proposed in this embodiment may include intelligent dressings in addition to those mentioned in embodiment 1. The intelligent dressing can be mainly used for monitoring one or more of the local temperature, humidity, pH value, oxygen content, NO concentration, microorganisms and the environmental pressure of the wound surface.

The intelligent dressing can be prepared by the following method: a monitoring device adopting a flexible circuit board or a common circuit board; then the CPU control module, an input module, an output module, a Bluetooth module, a sensor module, a storage module and a power supply module which are all interacted with the CPU control module are arranged on the flexible circuit board or the common circuit board; and embedding the mounted flexible circuit board or the common circuit board into the common dressing.

The sensor module comprises a temperature sensor, a humidity sensor, a pH sensor, an oxygen sensor, an NO concentration sensor, a microorganism sensor and a pressure sensor, which are electrically connected with the CPU control module and used for monitoring wound surface information of a patient and transmitting the wound surface information to the CPU control module.

The temperature sensor can be used for monitoring the temperature of the wound surface. The temperature can be used as an index of whether the wound surface is infected or not and the blood flow of the wound surface, and the temperature rise often indicates that the wound surface is infected.

The humidity sensor can be used for monitoring the humidity content of the wound surface. The healing speed is faster in a wet environment than in a dry environment, and the wet environment can not only maintain the survival of cells and enable the cells to release growth factors, but also regulate and stimulate the proliferation of the cells.

The pH sensor can be used for monitoring the pH value of the wound surface. The pH value of the wound surface is one of important influencing factors in the healing process, and the wound surface has different pH value ranges in different healing stages. The oxygen sensor may be used to monitor the oxygen content of the wound surface. The microbial sensor can be used for monitoring whether bacterial infection exists on the wound surface. The wound infection is one of important influencing factors in the healing process, a plurality of suppurative bacteria generate toxins and enzymes, and tissue necrosis and matrix or collagen fiber dissolution can be caused, so that local tissue injury is aggravated, healing is hindered, whether the wound is infected or not can be timely found through a microbial sensor, medicines such as antibiotics and the like can be timely and reasonably used, and wound infection can be prevented from occurring and aggravating.

The intelligent dressing can be paired with at least one central processing unit in advance so as to be capable of transmitting real-time physiological information acquired by the intelligent dressing to the central processing unit or a wound cavity environment analysis module in the central processing unit for processing. The patch pump can also transmit the real-time physiological information acquired by the patch pump to a central processor or a wound cavity environment analysis module in the central processor for processing.

The intelligent dressing/patch pump can monitor the wound surface information such as the actual wound cavity environment of the wound surface of a patient in real time and real-time physiological information, and the expected local post-injection physiological data processed by the central processing unit corresponds to the wound surface information. Therefore, the display mode of the medicine scheme obtained by the central processing unit also at least comprises that after the medicine scheme is selected, the expected local post-injection physiological data corresponding to the medicine scheme and the actual monitoring data obtained by processing by the wound cavity environment analysis module are intuitively compounded in the same graph based on the selected medicine scheme, and the change trend of the two data with time is displayed in a comparison mode.

Example 3

As shown in fig. 3, this embodiment proposes a comprehensive wound management method. This embodiment may be a further improvement and/or addition to embodiments 1 and 2, and the repeated description is omitted. In addition to this embodiment, the preferred implementation of the other embodiment may be provided in whole and/or in part without conflict or contradiction. The chronic wound assessment management method at least comprises one or more of the following steps S1 to S10, wherein the following step numbers are not to be understood as limiting the execution sequence of the steps, and one or more of the following steps can be processed in a time-sharing manner or in parallel manner:

s1: and sending a wound measurement instruction to the wound scanning module according to the medical operation instruction.

S2: and acquiring an image of the wound surface of the patient according to the wound surface measurement instruction from the central processing unit.

S201: and acquiring a target area image by using the first light, and identifying wound surface information in the target area image at least based on the target area image, wherein the wound surface information at least comprises a wound cavity main body area and/or a part of visible wound cavities.

S202: based on the wound cavity main body area and the wound information provided by the patient, it is predictable that the wound cavity extension area adjacent to the wound cavity main body area, which cannot be identified by the first wound surface scanning module from the skin surface layer, is isolated from the wound cavity area, and the target area is updated based on the isolated wound cavity area, the wound cavity extension area and the wound cavity main body area.

S203: and acquiring an updated target area image by using the second light, and identifying at least first real-time blood vessel information in the isolated wound cavity area image and/or second real-time blood vessel information in the wound cavity extension area and/or third real-time blood vessel information in the wound cavity main body area based on the updated target area image.

S3: and establishing a three-dimensional model about the wound surface at least based on the image data obtained after the treatment of the wound surface scanning module.

S301: based on the first real-time vascular information and the wound information provided by the patient, a second simulation model for simulating the vascular morphology at the pre-wound target region is obtained through reverse three-dimensional simulation construction.

S302: and based on one or more of the first to third real-time blood vessel information, performing spatial cutting on the updated second simulation model to obtain a plurality of spatial layers positioned at different depths of the skin.

S303: and according to the second real-time blood vessel information, the third real-time blood vessel information and the wound information provided by the patient, obtaining a third simulation model for indicating the local blood vessel morphology in the target area before the wound through reverse three-dimensional simulation construction.

S304: and respectively carrying out space layer labeling on the second simulation model and the third simulation model.

S305: and (3) reversely verifying the second simulation model according to the continuous blood vessel model and the spatial layer label corresponding to the continuous blood vessel model determined in the third simulation model to obtain a verified and updated second simulation model.

S306: and (3) performing space cutting on the second simulation model at least according to the determined discontinuous blood vessel model and the corresponding space layer label in the third simulation model, and dividing to obtain a missing part simulation model for roughly outlining the internal form of the wound cavity.

S307: the missing part simulation model can be subjected to boundary processing according to wound information acquired by the first wound scanning module and wound information provided by a patient, so that a missing part simulation model which is updated in processing and used for indicating the internal form of the finely contoured wound cavity is obtained.

S4: the relationship between the current wound information of the patient and the expected local physiological data fluctuation value of the wound within a predetermined period of time after the expected drug injection in the drug regimen is determined based on the historical data of the patient in a manner wherein the historical insulin injection data is correlated with the physiological data.

S5: simulating local post-injection physiological data that is expected to occur after at least physiological information related to a patient's blood glucose is negatively correlated by the local physiological data fluctuation value.

S6: at least one of the drug regimens is generated from the simulated local post-injection physiological data.

S7: a medication regimen is delivered to the patch pump in response to an indication of the operation of the medical care. Wherein at least one of the drug regimens created based at least on a wound retest cycle determined by the central processor from physiological information related at least to the patient's blood glucose may be generated from the simulated local post-injection physiological data and provided on a display interface of the central processor and/or a smart device operated by a medical care in at least two different display modes.

S8: and instructing the patch pump to perform wound medicine injection according to the medicine scheme.

Example 4

The embodiment provides a comprehensive wound surface management system. This embodiment may be a further improvement and/or addition to embodiments 1 to 3, and the repeated description is omitted. In addition to this embodiment, the preferred implementation of the other embodiment may be provided in whole and/or in part without conflict or contradiction. The comprehensive wound surface management system can mainly comprise at least one wound surface scanning module and a central processing unit. In some embodiments, the wound scan module may include a first wound scan module and a second wound scan module. The central processing unit may include a second analog processing module, a third analog processing module, and a first analog processing module.

The first wound surface scanning module can acquire an image of a target area by using first light. The first wound surface scanning module can at least identify wound surface information in the target area image based on the acquired target area image. The wound information may include a main body area of the wound cavity and a portion of the visible wound cavity. The main body area of the wound cavity mentioned herein mainly refers to the wound surface contour on the skin of the limb, i.e. the area corresponding to the open end face of the wound on the affected limb, obtained by using the structured light 3D measurement technique. The part of the visible invasive cavity mainly means that the structured light 3D measuring technology is limited by the dead angle of the detected light, the whole complete invasive cavity inner wall can not be completely detected, and only the incomplete invasive cavity inner wall, namely, the part of the visible invasive cavity, can be detected. The "visibility" in the partially visible wound cavity is primarily directed herein to the interpretation that can be detected by the first wound scan module. The target area may refer to at least, but is not limited to, the area of the limb where the wound is located. The first wound surface scanning module can adopt a wound surface management system eKare in Sight, and the 3D structure of the wound surface can be obtained by using low-energy infrared signals. However, because of the unsolvable problem of the dead angle obstacle of the detection light existing in the structured light 3D measurement technology, the 3D structure obtained by the first wound scanning module is not a complete and reliable practical situation. The structured light 3D measurement technology mentioned herein mainly includes that during monitoring, structured light is emitted to the whole monitored space through an infrared emitter, any position in the space can be marked by the structured light, after the whole space is marked, a 3D structured light sensor can identify the specific position of a tracked target in a three-dimensional space, then required data is calculated according to different photoelectric codes, and the depth and volume of a part of visible invasive cavity can be measured.

In the aspect of height and wound cavity volume measurement, when the wound cavity belongs to a 'forward conical' wound cavity with a small mouth and large bottom, light is enough to reach all parts and edges of the wound cavity completely, and the condition of a wound surface can be well exposed, so that under the condition, the complete information of the wound cavity can be well acquired only by relying on a single first wound surface scanning module. When the wound cavity obviously does not belong to a 'forward conical' wound cavity with a small opening outsole, or a doctor cannot clearly judge the invisible extension of the depth-free wound cavity, namely the first wound surface scanning module and the second wound surface scanning module provided by the application are combined and matched with a plurality of simulation processing modules, the wound cavity which cannot be solved by only relying on a single wound surface scanning module is processed, so that the invisible wound cavity is restored through three-dimensional modeling.

The second wound surface scanning module can acquire updated target area images by using second light rays. The second wound surface scanning module can at least identify first real-time blood vessel information in the isolated wound cavity area image, second real-time blood vessel information in the wound cavity extension area and third real-time blood vessel information in the wound cavity main body area based on the updated target area image. For easy understanding, the following description will be given first to the target area update module included in the comprehensive wound management system of the present application:

The comprehensive wound management system also comprises a target area updating module. The target area updating module can be mainly used for reasonably dividing the limb skin area according to the actual condition of a patient so as to obtain a target area capable of indicating the target range of subsequent treatment. The target region update module may determine a wound cavity extension region and an isolated wound cavity region as shown in fig. 3. The wound cavity extending area is an area adjacent to the wound cavity main body area and can not be identified from the skin surface layer by the first wound surface scanning module. The term "wound cavity extension region" refers to a wound cavity main body region, which refers to a wound cavity space where a first light ray emitted by a first wound surface scanning module penetrates through an open end of a wound surface and can be detected. In contrast, the "wound cavity extension region" corresponds to: the first light emitted by the first wound scanning module penetrates through the open end of the wound, and the part which cannot be detected cannot be seen by the wound cavity space. A partially invisible wound cavity space may or may not be present. The "extended area of the wound cavity" is provided to ensure complete detection of the complete wound cavity. The immediate wound cavity extension region is a region where the virtual presence of the invisible wound cavity is determined by prediction. The determination of the extended area of the wound cavity will be described below. The "isolated wound cavity region" is the limb region where the wound cavity is absent relative to the wound cavity extension region and the wound cavity body region. The main body area of the wound cavity is the central position of the target area, the outer layer of the main body area is an immediate wound cavity extension area which is annularly arranged outside the main body area, and the outermost layer is divided into isolation wound cavity areas.

The target region update module may predictably derive a wound cavity extension region and an isolated wound cavity region based on a wound cavity body region and wound information provided by a patient. The wound information provided by the patient may refer to the basic condition about the formation of a wound that can be obtained by a medical staff member through observation with the patient or its accompanying person or himself. The wound information may include the time of the wound generation, the cause, the treatment regimen, the type of wound, the infection, the wound location, the stage of the wound, the size of the wound, etc. Part of the wound information (e.g., wound type, infection, wound location, wound stage, wound size, etc.) may be analyzed by the first wound scan module after acquisition of the image of the target area. The wound information may be only the target area image acquired by the first wound scanning module. The target area updating module can upload the acquired wound cavity main area and wound information to cloud side equipment for processing, and the cloud side equipment feeds back the wound cavity extension area and the isolated wound cavity area obtained after processing to the target area updating module.

The cloud-side device may process to obtain a wound cavity extension region and an isolated wound cavity region based on a retrieval rule that the visual vocabulary matches multiple features. The cloud side device is configured to store historical wound information of different affected parts of different patients uploaded by different target area updating modules or the same target area updating module. The historical wound information may include determined wound information after evaluation and/or after verification using the integrated wound management system set forth herein. And processing the stored historical wound information, and extracting at least one first-stage classification feature, two-stage classification feature and three-stage classification feature in the historical wound information. The cloud-side device may cluster at least one primary classification feature to construct a plurality of primary classification tables. The first order classification characteristic may refer to one or a combination of several of wound type, wound location, wound stage, and wound size. The cloud-side device may process at least one historical wound information contained in each primary classification table and cluster based on at least one secondary classification feature to construct a plurality of secondary classification tables. The secondary classification characteristic may refer to one or a combination of several of patient age, patient gender, patient physical condition score, etc. The cloud-side device may process at least one historical wound information contained in each secondary classification table, and cluster based on the tertiary classification features to construct a plurality of tertiary classification tables. The three-level classification feature may refer to at least one area division ratio with different adoption rates determined after evaluation and/or verification by using the comprehensive wound management system provided by the application. The cloud side equipment can process and extract the currently uploaded wound information to obtain at least one primary classification feature, at least one secondary classification feature and at least one tertiary classification feature, and match the currently uploaded wound information into a corresponding tertiary classification table based on the extracted classification features. Based on the above, the cloud side device can generate one or more of the wound cavity main body area, the wound cavity extension area and the isolated wound cavity area by combining the current uploaded wound information according to the area division proportion with the highest adoption rate corresponding to the three-level classification table obtained by matching the cloud side device. Based on the above, the cloud side device can feed back one or more of the generated wound cavity main body region, the wound cavity extension region and the isolated wound cavity region to the target region updating module based on the one-to-three-level classification features extracted from the currently uploaded wound information.

Based on the updated target region image, first real-time blood vessel information in the isolated lumen region image, second real-time blood vessel information in the extended lumen region, and third real-time blood vessel information in the main lumen region may be identified. The updated target area image can be the image of the main area of the wound cavity, the image of the extension area of the wound cavity and the image of the isolated wound cavity area. The real-time blood vessel information can refer to the trend, the blood flow condition, the blood vessel depth and other information of the blood vessel at the affected limb, which can be acquired by the second wound surface scanning module. The second wound surface scanning module can be a blood vessel perspective instrument, and the characteristic that hemoglobin in blood in human tissue has more obvious absorption effect on infrared light than surrounding tissues is utilized, so that when the infrared camera lens is used for shooting, optical contrast is generated between blood vessels and surrounding tissues, further, the position of subcutaneous blood vessels can be clearly displayed, and obvious blood vessel images can be obtained. The blood vessel image is processed to obtain the trend, blood flow condition, blood vessel depth and other information of the blood vessel at the affected limb. Thus the long wavelength band has a higher skin penetration capacity than the short wavelength band. The long wave band is suitable for feeding back deep skin tissue information. For the selection of different wave bands, the power of the light source can be determined by controlling the corresponding filter and the intensity of the light after passing through the filter. The second wound surface scanning module can acquire three-dimensional images of the blood vessel morphology of the damaged limb by means of a plurality of blood vessel morphology reference models of different types. The blood vessel morphology reference model may refer to a reference model which is obtained based on big data and commonly comprises blood vessel morphology and distribution, and can be used for assisting in establishing the second simulation model and the third simulation model. The second wound surface scanning module can acquire a three-dimensional image of the blood vessel morphology of the damaged limb by using one or more of spiral CT detection technology and CAG, IVUS, MRA. The second wound surface scanning module can perform local modeling based on the obtained three-dimensional image and then combine the first real-time blood vessel information, so as to realize the establishment of a preliminary three-dimensional model.

The second wound surface scanning module can transmit the acquired first real-time blood vessel information to the second simulation processing module for processing, and the second simulation processing module can process the first real-time blood vessel information to obtain a second simulation model. Preferably, the second wound surface scanning module can transmit the initial three-dimensional model and the first real-time blood vessel information established by the second wound surface scanning module to the second simulation processing module for processing, and the second simulation processing module can process the initial three-dimensional model and the first real-time blood vessel information to obtain a second simulation model. The second simulation model may be referred to as being used to simulate the morphology of a blood vessel at a pre-traumatic target area, where the target area refers to a main area of the wound cavity, an extended area of the wound cavity, and an isolated area of the wound cavity. That is, the second simulation processing module may be configured via inverse three-dimensional simulation based on the first real-time vascular information and the wound information provided by the patient to derive a second simulation model. Based on the wound information provided by the patient, at least one pre-stored real-time vascular information adapted thereto may be retrieved. The pre-stored real-time blood vessel information mainly refers to simulation configuration parameters such as blood vessel trend, blood flow condition, blood vessel depth and the like which are obtained by pre-matching based on big data processing according to wound information such as different sexes and different occupations in different age groups. Based on the above, the second simulation processing module may obtain the second simulation model by adopting a reverse three-dimensional simulation construction mode. Since the second simulation processing module processes based only on the first real-time blood vessel information, the second simulation model is used for simulating the blood vessel morphology before injury at the target area.

The second wound surface scanning module can transmit the acquired second and third real-time blood vessel information to the third simulation processing module for processing so as to obtain a third simulation model. Preferably, the second wound surface scanning module can transmit the initial three-dimensional model and the second and third real-time blood vessel information established by the second wound surface scanning module to the third simulation processing module for processing, and the third simulation processing module can process the initial three-dimensional model and the second and third real-time blood vessel information to obtain a third simulation model. The third simulation model may refer to a local area of the target area, namely the main body area of the wound cavity and the extension area of the wound cavity. That is, the third simulation processing module may construct a third simulation model via inverse three-dimensional simulation based on the second real-time blood vessel information, the third real-time blood vessel information, and the wound information provided by the patient. The wound information provided by the patient herein refers primarily to the time of the wound generation, the cause, the treatment regimen, the type of wound, the infection, the wound location, the wound stage, the size of the wound, etc. In this application, the wound information provided by the patient may refer to one to three classification features extracted by the cloud-side device based on the currently uploaded wound information. Based on the wound information provided by the patient, at least one pre-stored real-time vascular information adapted thereto may be retrieved. The pre-stored real-time blood vessel information can comprise wound information such as time generated according to different wounds, wound positions, wound phases, wound sizes and the like, and simulation configuration parameters such as blood vessel morphology change and the like in a certain time after being wounded are obtained by pre-matching based on big data processing. Based on the method, the third simulation model can be obtained by adopting an inverse three-dimensional simulation construction mode. The third simulation model is only constructed based on the inverse three-dimensional simulation of the second and third real-time blood vessel information, namely, the third simulation model is mainly used for simulating the blood vessel morphology before the wound cavity and the adjacent area thereof.

The third simulation model is different from the second simulation model, the second simulation model is obtained by simulation construction except for isolating the wound cavity region, and the third simulation model is not obtained by simulation correction of the obtained wound cavity main body region and the wound cavity extension region based on pre-stored real-time blood vessel information. Preferably, the third simulation model may include a continuous vessel model and a discontinuous vessel model. Due to the influence of the wound cavity, a part of blood vessels are damaged, so that complete continuous blood vessels cannot be monitored, while blood vessels which are positioned at the bottom of the wound cavity and are not influenced by the wound cavity are not damaged, and complete continuous blood vessels can be monitored.

The comprehensive wound surface management system provided by the application further comprises a fourth simulation processing module. And the fourth simulation processing module is used for performing space cutting on the simulation three-dimensional model according to the real-time blood vessel information. And a fourth simulation processing module for performing spatial cutting on the updated second simulation model based on one or more of the first to third real-time blood vessel information. The fourth analog processing module may obtain multiple spatial layers at different depths of the skin.

And the fourth simulation processing module can respectively carry out space layer labeling on the second simulation model and the third simulation model. And matching and corresponding the second simulation model and the third simulation model through the spatial layer labeling. And the second simulation processing module can perform reverse verification on the second simulation model according to the continuous blood vessel model determined in the third simulation model and the spatial layer label corresponding to the continuous blood vessel model to obtain a verified and updated second simulation model. That is, based on the spatial layer labeling of the continuous vessel model, a partial model obtained by simulation construction in the second simulation model is called out. And comparing the continuous blood vessel model obtained by simulation correction in the third simulation model, and performing reverse verification according to the continuous blood vessel model. After reverse verification, updated and more accurate simulation configuration parameters (the pre-stored real-time blood vessel information) can be obtained. Based on the updated simulation configuration parameters, small-range adjustment is performed on other partial models obtained by simulation construction in the second simulation model, so that the second simulation model after verification and updating can be obtained.

And the fourth simulation processing module can adopt a plurality of sliding slices to further cut the plurality of space layers to obtain subdivided space blocks which are distributed in each space layer to jointly form a space layer. And the fourth simulation processing module can perform space cutting on the second simulation model according to the third simulation model (at least comprising a continuous blood vessel model and a discontinuous blood vessel model) and the corresponding space layer labels, so that the missing part simulation model can be obtained by segmentation. The missing part simulation model obtained by segmentation is only the internal form of the wound cavity formed by rough sketching of a plurality of subdivision space blocks. The first simulation processing module can perform boundary processing on the missing part simulation model according to wound information acquired by the first wound scanning module and wound information provided by a patient, and update the missing part simulation model. The missing part simulation model is an internal form of a wound cavity formed by finely outlining a plurality of subdivision space blocks. The wound surface information comprises a partial wound cavity capable of truly reflecting parameters such as volume depth and the like, and the missing part simulation model can be further updated and adjusted based on the partial wound cavity, so that the wound surface information is more in line with the shape of the real wound cavity.

Furthermore, it should be understood that the order of the elements and sequences recited in the specification, the use of numerical letters, or other designations should not be used to limit the order of the flows and methods of the specification unless explicitly recited in the claims. While certain presently useful inventive embodiments have been discussed in the foregoing disclosure, by way of various examples, it is to be understood that such details are merely illustrative and that the appended claims are not limited to the disclosed embodiments, but, on the contrary, are intended to cover all modifications and equivalent arrangements included within the spirit and scope of the embodiments of the present disclosure. For example, while the system components described above may be implemented by hardware devices, they may also be implemented solely by software solutions, such as installing the described system on an existing processing device or mobile device. It should be noted that the above-described embodiments are exemplary, and that a person skilled in the art, in light of the present disclosure, may devise various solutions that fall within the scope of the present disclosure and fall within the scope of the present disclosure. It should be understood by those skilled in the art that the present description and drawings are illustrative and not limiting to the claims. The scope of the invention is defined by the claims and their equivalents. The description of the invention encompasses multiple inventive concepts, such as "preferably," "according to a preferred embodiment," or "optionally," all means that the corresponding paragraph discloses a separate concept, and that the applicant reserves the right to filed a divisional application according to each inventive concept.

Claims

1. A comprehensive wound surface management system at least comprises a wound surface scanning module and a central processing unit,

wound surface scanning module: the device is used for collecting images of wound surfaces of patients according to wound surface measurement instructions from the central processing unit;

and the central processing unit: is used for sending a wound measurement instruction to the wound scanning module according to the operation instruction of medical care, and establishing a three-dimensional model related to the wound based on at least the image data obtained after the treatment of the wound scanning module,

the comprehensive wound surface management system is characterized by further comprising:

a patch pump for being worn in the vicinity of a wound of a patient and performing wound drug injection according to a drug regimen from the central processor, and/or indirectly acquiring physiological information related to at least blood sugar of a patient wearing the patch pump in a non-invasive manner and transmitting the physiological information to a central processor pre-paired with the patch pump and provided with at least a physiological information analysis module in response to a wound measurement instruction of the central processor,

before the central processor transmits a medication regimen to the patch pump in response to an indication of operation of the medical care, the central processor determines a relationship between current wound information of the patient and expected local physiological data fluctuation values of the wound in a predetermined period of time after expected medication injection in the medication regimen based on historical data of the patient in a manner in which historical insulin injection data is associated with physiological data, and simulates, by using a physiological information analysis module, local post-injection physiological data expected to occur after negative correlation by the local physiological data fluctuation values of at least physiological information related to blood glucose of the patient from the wound scanning module and/or the patch pump, and generates at least one of the medication regimens from the simulated local post-injection physiological data.

2. The integrated wound management system of claim 1, wherein the central processor generates and provides at least one of the drug regimens created based at least on a wound retest cycle determined by the central processor from physiological information related at least to a patient's blood glucose in accordance with the wound scan module and/or the patch pump on a display interface of the central processor and/or a medical operated intelligent device in at least two different display modes.

3. The integrated wound management system of claim 2, further comprising:

the intelligent dressing is used for covering the wound surface of a patient, collecting wound surface information, which is at least related to the wound cavity environment, of the wound surface which is covered with the intelligent dressing and is not open, according to a drug scheme from the central processing unit, and sending the wound surface information to the central processing unit which is paired with the intelligent dressing in advance and is provided with at least a wound cavity environment analysis module, so that at least one drug scheme can be provided to the central processing unit and/or a display interface of intelligent equipment operated by medical care in a display mode that predicted data are compared with actual monitoring data.

4. The comprehensive wound management system according to any one of claims 1 to 3, wherein the wound scanning module at least comprises:

the first wound surface scanning module is used for acquiring a first target area image by utilizing first light rays and identifying wound surface information in the first target area image at least based on the first target area image; and/or

The second wound surface scanning module is used for acquiring a second target area image by utilizing second light rays, and identifying one or more real-time blood vessel information at least comprising first real-time blood vessel information corresponding to an isolated wound cavity area, second real-time blood vessel information corresponding to an extended wound cavity area and third real-time blood vessel information corresponding to a main wound cavity area in the second target area image based on the second target area image.

5. The integrated wound management system of claim 4, wherein the central processor further comprises:

the first simulation processing module is used for obtaining a second simulation model obtained by carrying out reverse three-dimensional simulation construction on first real-time blood vessel information corresponding to the isolated wound cavity area in combination with the wound surface information identified by the first wound surface scanning module, and a third simulation model obtained by carrying out reverse three-dimensional simulation construction on second real-time blood vessel information corresponding to the wound cavity extension area and third real-time blood vessel information corresponding to the wound cavity main body area in combination with the wound surface information identified by the first wound surface scanning module, and generating a first simulation model for evaluating chronic wound surfaces by utilizing the second simulation model and the third simulation model.

6. The integrated wound management system of claim 5, further comprising:

the recording device is used for collecting wound surface information recorded in a non-image processing mode; and/or

And the target area updating module is used for carrying out area prediction by combining the wound cavity main area with the wound surface information which is at least obtained by the input equipment and the first wound surface scanning module when the first wound surface scanning module carries out image processing on the first target area to obtain the wound cavity main area, so as to obtain a wound cavity extending area which is adjacent to the wound cavity main area and cannot be identified by the first wound surface scanning module from the skin surface layer, and an isolated wound cavity area which is adjacent to the wound cavity extending area and at least does not identify a wound surface from the skin surface layer, and updating the first target area based on the wound cavity extending area to obtain a second target area which at least comprises the isolated wound cavity area, the wound cavity extending area and the wound cavity main area.

7. The integrated wound management system of claim 6, wherein the target region update module processes based on a wound cavity main region obtained by the first wound scan module after processing the first target region image and at least including wound surface information obtained by the first wound scan module with a first projection rule and an entry device respectively, to obtain a second target region which is required for the second simulation model and the third simulation model to perform space-time interactive reverse verification update and at least includes an isolated wound cavity region, a wound cavity extension region and a wound cavity main region,

The first simulation model is generated in a manner such that the first simulation processing module can update the second simulation model and the third simulation model through space-time interactive reverse verification based on the second target area.

8. A comprehensive wound surface management method, which is characterized by at least comprising one or more of the following steps:

image acquisition is carried out on the wound surface of the patient according to the wound surface measurement instruction from the central processing unit;

sending a wound measurement instruction to a wound scanning module according to the operation instruction of medical care, and establishing a three-dimensional model about the wound based on at least image data obtained after the treatment of the wound scanning module;

determining a relationship between current wound information of the patient and expected local physiological data fluctuation values of the wound within a predetermined period of time after an expected drug injection in the drug regimen based on historical data of the patient in a manner in which the historical insulin injection data is correlated with the physiological data;

simulating local post-injection physiological data that is expected to occur after at least physiological information related to a patient's blood glucose is negatively correlated by the local physiological data fluctuation value;

generating at least one of the drug regimens from the simulated local post-injection physiological data;

Transmitting a medication regimen to the patch pump in response to an indication of the operation of the medical care;

and instructing the patch pump to perform wound medicine injection according to the medicine scheme.

9. The method according to claim 8, characterized in that the method further comprises the steps of:

at least one of the drug regimens created based at least on a wound retest cycle determined by the central processor from physiological information related at least to the patient's blood glucose is generated from the simulated local post-injection physiological data and provided in at least two different display modes on a display interface of the central processor and/or a smart device operated by a medical care.

10. The method according to claim 9, characterized in that the method further comprises the steps of:

acquiring a first target area image by using first light rays, and identifying wound surface information in the first target area image at least based on the first target area image; and/or

And acquiring a second target area image by utilizing second light rays, and identifying one or more real-time blood vessel information at least comprising first real-time blood vessel information corresponding to the isolated wound cavity area, second real-time blood vessel information corresponding to the wound cavity extension area and third real-time blood vessel information corresponding to the wound cavity main body area in the second target area image based on the second target area image.