CN112136809A - Compound solid fumigation disinfectant and using method thereof - Google Patents

Compound solid fumigation disinfectant and using method thereof Download PDF

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CN112136809A
CN112136809A CN202011083326.7A CN202011083326A CN112136809A CN 112136809 A CN112136809 A CN 112136809A CN 202011083326 A CN202011083326 A CN 202011083326A CN 112136809 A CN112136809 A CN 112136809A
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compound solid
peroxide
sodium
activator
pentaacetylglucose
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严敬华
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Zhejiang Shiweikang Biomedical Materials Co ltd
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Zhejiang Shiweikang Biomedical Materials Co ltd
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/18—Vapour or smoke emitting compositions with delayed or sustained release
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds

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  • General Health & Medical Sciences (AREA)
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  • Pest Control & Pesticides (AREA)
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  • Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
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Abstract

The invention relates to the technical field of solid disinfectants, in particular to a compound solid fumigation disinfectant and a using method thereof, wherein the compound solid fumigation disinfectant comprises peroxide and an activating agent, and the weight ratio of the peroxide to the activating agent is 1: (1-1.5). The compound solid fumigation disinfectant provided by the invention has strong and quick sterilizing capability, and can be used for comprehensively sterilizing narrow spaces and dead corners; meanwhile, the disinfectant has little corrosivity on a disinfection object, and the disinfectant has no residue after disinfection and is easy to clean; in addition, the compound solid fumigation disinfectant provided by the invention has good storage stability and can be stored for a long time.

Description

Compound solid fumigation disinfectant and using method thereof
Technical Field
The invention relates to the technical field of solid disinfectants, in particular to a compound solid fumigation disinfectant and a using method thereof.
Background
On the site of a flammable and explosive dangerous chemical disaster accident, the storage capacity of chemicals is large, the types of chemicals are various, secondary disasters are easy to cause, and the disposal difficulty is high; in particular, the number of the polluted objects is various, and the disinfection disposal environment is complicated. In the emergency rescue of chemical accidents, a large amount of closed spaces or relatively narrow spaces are often disinfected, and once the disinfection is not properly treated, serious damage can be caused, and the disinfection cannot work. At present, most of traditional disinfectants mainly wash and disinfect liquid in a wide area and on the surface of equipment, and cannot thoroughly disinfect a relatively closed space; some gaseous disinfectants, such as chlorine dioxide, require a ready-to-use process or, such as hydrogen peroxide, require liquid volatilization generation. In addition, the sterilization efficiency of the traditional disinfectant still needs to be improved, and meanwhile, how to conveniently transport and store the disinfectant still needs to be solved.
Disclosure of Invention
In view of the problems in the prior art, the first aspect of the present invention provides a compound solid fumigant comprising a peroxide and an activator, wherein the weight ratio of the peroxide to the activator is 1: (1-1.5).
In a preferred embodiment of the present invention, the peroxide is selected from one or more of urea peroxide, percarbonate, perborate, perphosphate, and persilicate.
In a preferred embodiment of the present invention, the percarbonate is coated percarbonate having a particle size of 20 to 40 mesh.
As a preferable technical scheme of the invention, the activating agent is selected from one or more of tetraacetylethylenediamine, aspirin, tetraacetylglycoluril, tetraacetylaldopentose, pentaacetylglucose and sodium nonanoylbenzenesulfonate.
As a preferred embodiment of the present invention, the activating agent comprises pentaacetylglucose and sodium nonanoylbenzene sulfonate; the pentaacetylglucose is alpha-pentaacetylglucose and/or beta-pentaacetylglucose.
As a preferable technical scheme of the invention, the weight ratio of the pentaacetylglucose to the sodium nonanoylbenzene sulfonate is 1: (6-10).
As a preferable technical solution of the present invention, the compound solid fumigation disinfectant further comprises an activator, which is selected from one or more of citric acid, sodium citrate and carbonate.
As a preferable technical scheme of the invention, the sodium citrate is sodium citrate dihydrate and/or sodium citrate pentahydrate.
As a preferable technical scheme of the invention, the compound solid fumigation disinfectant also comprises linear alkyl benzene sulfonate, wherein the carbon number of an alkyl chain of the linear alkyl benzene sulfonate is 9-12.
The invention provides a use method of the compound solid fumigation disinfectant, which comprises the following steps: heating the compound solid fumigation disinfectant at 60-70 ℃ while ultrasonically vibrating.
Compared with the prior art, the invention has the following beneficial effects:
the compound solid fumigation disinfectant provided by the invention has strong and quick sterilizing capability, and can be used for comprehensively sterilizing narrow spaces and dead corners; meanwhile, the disinfectant has little corrosivity on a disinfection object, and the disinfectant has no residue after disinfection and is easy to clean; in addition, the compound solid fumigation disinfectant provided by the invention has good storage stability and can be stored for a long time.
Detailed Description
In a first aspect, the invention provides a compound solid fumigant comprising a peroxide and an activator.
In one embodiment, the weight ratio of peroxide to activator is 1: (1-1.5).
Preferably, the weight ratio of peroxide to activator is 1: 1.2.
in one embodiment, the compound solid fumigant further comprises a stimulant.
Preferably, the weight ratio of the activator to peroxide is (0.2-0.8): 1; more preferably, the weight ratio of the activator to peroxide is 0.6: 1.
in one embodiment, the composite solid fumigant further comprises linear alkyl benzene sulfonate.
Preferably, the weight ratio of linear alkylbenzene sulphonate to activator is (0.01-0.08): 1; more preferably, the weight ratio of linear alkylbenzene sulphonate to activator is from 0.05: 1.
peroxides and their use in the preparation of pharmaceutical preparations
Peroxide refers to a compound containing a peroxy-O-O-. Can be used as hydrogen peroxide derivative, and is characterized by containing peroxide ions in the molecule. Peroxides are divided into inorganic peroxides and organic peroxides. Peroxides play an important role in the textile industry, bleaching industry.
In one embodiment, the peroxide is selected from one or more of urea peroxide, percarbonate, perborate, perphosphate, persilicate.
Urea peroxide: the appearance is white crystal powder, the powder is non-toxic and odorless, and the theoretical active oxygen content is as follows: 16.0%, H2O2The content is as follows: 35.0 percent, is easy to dissolve in water, and the aqueous solution has the properties of both urea and hydrogen peroxide. Decomposed into urea and H in water2O2And atomic oxygen, and slowly release O2. The active oxygen content is high, the solubility in water is high, the pH value of the aqueous solution is nearly neutral, the stability is good, the effect time is long, no side effect is caused, and the detergent is non-toxic and pollution-free and is an updating product of traditional peroxides such as sodium percarbonate and the like.
Preferably, the percarbonate is coated percarbonate.
Preferably, the percarbonate has a particle size of 20-40 mesh.
In a preferred embodiment, the peroxide is percarbonate.
The specific type of percarbonate used in the present invention is not particularly limited, and may be selected by those skilled in the art in a conventional manner.
Preferably, the percarbonate is sodium percarbonate.
Sodium percarbonate is an inorganic substance, belongs to a strong oxidant, and has a molecular formula of 2Na2CO3·3H2O2Or Na2CO3·1.5H2O2. The appearance is white crystal or crystalline powder, and oxygen can be released when the powder is wet. Sodium percarbonate is an addition compound of hydrogen peroxide and sodium carbonate, and is mainly used as a bleaching agent and an oxidizing agent, and a detergent, a cleaning agent and a bactericide in chemical industry, papermaking, textile, dyeing and finishing, food, medicine, health and other departments. Other usesLike sodium perborate, sodium perborate can be replaced to save boron salts.
Preferably, the sodium percarbonate is coated sodium percarbonate.
Preferably, the particle size of the sodium percarbonate is 20 to 40 mesh.
The coated sodium percarbonate with the particle size of 20-40 meshes guarantees the shelf life to a certain extent.
Activating agent
The activating agent is a kind of regulator which can enhance the adsorption capacity of the mineral surface to the collecting agent in the flotation reagent. The method is used for eliminating the action of an inhibitor by changing the chemical composition of the surface of the mineral, so that the mineral is easy to adsorb the collecting agent. Such as ethylene diamine phosphate, propylene diamine phosphate, xylene, sodium fluorosilicate, ammonium sulfate, ammonium chloride, ferrous sulfate, ammonium hydroxide, etc.
In one embodiment, the activator is selected from one or more of tetraacetylethylenediamine, aspirin, tetraacetylglycoluril, tetraacetylaldopentose, pentaacetylglucose, sodium nonanoylbenzenesulfonate.
Aspirin: aspirin (Aspirin,2- (acetoxy) benzoic acid, also known as acetylsalicylic acid) is a white crystalline or crystalline powder, odorless or slightly acetogenic, sparingly soluble in water, readily soluble in ethanol, soluble in diethyl ether, chloroform, and acidic in aqueous solution.
Preferably, the pentaacetylglucose is alpha-pentaacetylglucose and/or beta-pentaacetylglucose; more preferably, the pentaacetylglucose is β -pentaacetylglucose.
In one embodiment, the activators are pentaacetylglucose and sodium nonanoylbenzenesulfonate.
Pentaacetylglucose is also known as glucose pentaacetate. There are alpha-pentaacetylglucose and beta-pentaacetylglucose isomers. The alpha-isomer is colorless needle crystal, the melting point is 112-113 ℃, and the alpha D20 is +101.6 degrees. Can be prepared from glucose, acetic anhydride and a little zinc chloride at 0 deg.C. The beta-isomer is colorless crystal, melting point is 134 deg.C, and alpha D20 is +3.8 deg.C. Can be obtained by co-heating glucose, acetic anhydride and sodium acetate. Dissolving pentaacetylglucose in glacial acetic acid and reacting with hydrobromic acid to obtain 1-bromo-tetraacetylglucose.
Preferably, the pentaacetylglucose is alpha-pentaacetylglucose and/or beta-pentaacetylglucose; more preferably, the pentaacetylglucose is β -pentaacetylglucose.
Preferably, the weight ratio of the pentaacetylglucose to the sodium nonanoylbenzenesulfonate is 1: (6-10); more preferably, the weight ratio of pentaacetylglucose to sodium nonanoylbenzenesulfonate is 1: 8.
CAS of sodium nonanoylbenzenesulfonate according to the invention: 89740-11-4.
It was found experimentally that when the weight of the activator is increased in order to increase the disinfection rate, the ratio of sodium percarbonate to activator by weight exceeds 1: 1, while reducing the amount of activator, the desired rate of hydrogen peroxide release is not achieved, and the applicants have unexpectedly found that when the activator is sodium pentaacetylglucose and nonanoylbenzene sulfonate, especially pentaacetylglucose is β -pentaacetylglucose, and the weight ratio of pentaacetylglucose to nonanoylbenzene sulfonate is 1: (6-10), when the weight ratio of sodium percarbonate to activator exceeds 1: 1, the release rate of the hydrogen peroxide is not reduced, but is improved, and the applicant believes that the possible reason is that the density of the solid fumigation disinfectant is reduced to a certain degree by the beta-pentaacetylglucose and the sodium nonanoylbenzene sulfonate, so that the generated hydrogen peroxide can quickly escape into the air, and meanwhile, the longer nonpolar hydrocarbon chain and the shorter polar group in the sodium nonanoylbenzene sulfonate make the molecules of the solid fumigation disinfectant express regularity and disorder to a certain degree, but are beneficial to the release of the hydrogen peroxide molecules. In addition, the applicant has unexpectedly found that the release rate of hydrogen peroxide is drastically reduced by an excessive proportion of beta-pentaacetylglucosamine in the activator.
Exciting agent
In one embodiment, the trigger is selected from one or more of citric acid, sodium citrate, and carbonate.
Preferably, the sodium citrate is sodium citrate dihydrate and/or sodium citrate pentahydrate; more preferably, the sodium citrate is sodium citrate dihydrate.
In a preferred embodiment, the trigger is sodium citrate.
Sodium citrate is also called sodium citrate and has the chemical formula C6H5Na3O7258.07, a compound with a chemical formula, colorless orthorhombic crystals, stable in air and a relative density of 1.859. Can be dissolved in water and glycerol, and is slightly soluble in ethanol. The aqueous solution has slight alkalinity, and has cool feeling when tasting. When heated to 100 ℃ it becomes a dihydrate salt. The latter are colorless monoclinic columnar crystals or granular powder, which are easily soluble in water. At 1450 ℃ it becomes anhydrous and decomposes at higher temperatures. Is commonly used as a buffer, a complexing agent and a bacteria culture medium, is used for promoting urination, eliminating phlegm, sweating and preventing blood coagulation in medicine, and is used in the aspects of food, beverage, electroplating, photography and the like.
Preferably, the sodium citrate is sodium citrate dihydrate and/or sodium citrate pentahydrate; more preferably, the sodium citrate is sodium citrate dihydrate.
The applicant finds that the storage stability can be improved by using sodium percarbonate in an encapsulated form, but the release rate of hydrogen peroxide is affected, and the disinfection efficiency is affected, and the applicant surprisingly finds that when sodium citrate, in particular sodium citrate dihydrate is used as an activator, the release rate of hydrogen peroxide is not hindered by the presence of crystal water but is further increased in the presence of sodium percarbonate in an encapsulated form, the applicant believes that the probable reason is that the crystal water in sodium citrate dihydrate is stable and does not decompose when the solid fumigation disinfectant is heated, the density of sodium citrate dihydrate is relatively high, the generated hydrogen peroxide does not bulge due to the presence of the crystal water, but due to the presence of 2 crystal waters in sodium citrate dihydrate during the heating process at 60-70 ℃, accelerate the decomposition of the protective film in the coated sodium percarbonate, especially the coated sodium percarbonate with the particle size of 20-40 meshes, promote the contact reaction between the sodium percarbonate and the beta-pentaacetylglucose in the activator and the sodium nonanoylbenzene sulfonate, and release hydrogen peroxide.
Straight chain alkyl benzene sulfonate
In one embodiment, the linear alkyl benzene sulfonate has an alkyl chain carbon number of from 9 to 12.
Preferably, the linear alkylbenzene sulfonate has an alkyl chain carbon number of 11.
The type of linear alkylbenzene sulfonate used in the present invention is not particularly limited and may be selected by those skilled in the art in a conventional manner.
In a preferred embodiment, the linear alkylbenzene sulfonate is sodium linear alkylbenzene sulfonate.
Preferably, the alkyl chain carbon number of the linear alkyl benzene sulfonic acid sodium salt is 11; more preferably, the sodium linear alkyl benzene sulphonate is sodium undecyl benzene sulphonate, CAS: 27636-75-5.
The applicant has surprisingly found that when the solid fumigant further comprises linear alkyl benzene sulphonate, especially linear alkyl benzene sulphonate having an alkyl carbon number of from 9 to 12, and the weight ratio of linear alkyl benzene sulphonate to activator is (0.01 to 0.08): 1, the bactericidal effect can be further improved, and the applicant believes that the possible reason is that linear alkyl benzene sulfonate with 9-12 carbon atoms in the alkyl group and sodium nonanoylbenzene sulfonate in the activating agent supplement each other, and under the coordination of sodium citrate dihydrate, in the heating use process at 60-70 ℃, linear alkyl benzene sulfonate molecular chains with 9-12 carbon atoms in the alkyl group and sodium nonanoylbenzene sulfonate molecular chains have the tendency of mutual cross winding, so that linear alkyl benzene sulfonate molecular chains with 9-12 carbon atoms in the alkyl group interact with sodium nonanoylbenzene sulfonate molecules and sodium percarbonate molecules, and simultaneously the surface tension is reduced, so that molecules with strong oxidation capability are generated.
In one embodiment, the preparation method of the compound solid fumigation disinfectant comprises the following steps: mixing peroxide, activator, excitant and linear alkyl benzene sulfonate, and pressing to obtain the final product.
The invention provides a use method of the compound solid fumigation disinfectant, which comprises the following steps: heating the compound solid fumigation disinfectant at 60-70 ℃ while ultrasonically vibrating.
In one embodiment, the method of using the compound solid fumigant includes: heating the compound solid fumigation disinfectant at 65 ℃ while ultrasonically vibrating.
Examples
Hereinafter, the present invention will be described in more detail by way of examples, but it should be understood that these examples are merely illustrative and not restrictive. The starting materials used in the examples which follow are all commercially available unless otherwise stated.
Example 1
Embodiment 1 of the present invention provides a compound solid fumigation disinfectant, which is composed of peroxide, an activator and linear alkyl benzene sulfonate; the weight ratio of the peroxide to the activator is 1: 1.1, the weight ratio of the exciting agent to the peroxide is 0.2: 1, the weight ratio of linear alkylbenzene sulfonate to activator is 0.01: 1.
the peroxide is percarbonate, the percarbonate is sodium percarbonate, the sodium percarbonate is coated sodium percarbonate with the particle size of 20-40 meshes, and is purchased from Jinjiangjin peroxide GmbH.
The activating agent is pentaacetylglucose and sodium nonanoylbenzene sulfonate, and the weight ratio of the activating agent to the activating agent is 1: 6; the pentaacetylglucose is beta-pentaacetylglucose.
The excitant is sodium citrate, and the sodium citrate is sodium citrate dihydrate.
The linear alkyl benzene sulfonate is linear alkyl benzene sodium sulfonate, the carbon number of an alkyl chain is 11, and the CAS: 27636-75-5.
The preparation method of the compound solid fumigation disinfectant comprises the following steps: mixing peroxide, activator, excitant and linear alkyl benzene sulfonate, and pressing to obtain the final product.
The application method of the compound solid fumigation disinfectant comprises the following steps: heating the compound solid fumigation disinfectant at 65 ℃ while ultrasonically vibrating.
Example 2
Embodiment 2 of the present invention provides a compound solid fumigation disinfectant, which is composed of peroxide, an activator and linear alkyl benzene sulfonate; the weight ratio of the peroxide to the activator is 1: 1.5, the weight ratio of the exciting agent to the peroxide is 0.8: 1, the weight ratio of linear alkylbenzene sulfonate to activator is 0.08: 1.
the peroxide is percarbonate, the percarbonate is sodium percarbonate, the sodium percarbonate is coated sodium percarbonate with the particle size of 20-40 meshes, and is purchased from Jinjiangjin peroxide GmbH.
The activating agent is pentaacetylglucose and sodium nonanoylbenzene sulfonate, and the weight ratio of the activating agent to the activating agent is 1: 10; the pentaacetylglucose is beta-pentaacetylglucose.
The excitant is sodium citrate, and the sodium citrate is sodium citrate dihydrate.
The linear alkyl benzene sulfonate is linear alkyl benzene sodium sulfonate, the carbon number of an alkyl chain is 11, and the CAS: 27636-75-5.
The preparation method of the compound solid fumigation disinfectant comprises the following steps: mixing peroxide, activator, excitant and linear alkyl benzene sulfonate, and pressing to obtain the final product.
The application method of the compound solid fumigation disinfectant comprises the following steps: heating the compound solid fumigation disinfectant at 65 ℃ while ultrasonically vibrating.
Example 3
Embodiment 3 of the present invention provides a compound solid fumigation disinfectant, which is composed of peroxide, an activator and linear alkyl benzene sulfonate; the weight ratio of the peroxide to the activator is 1: 1.2, the weight ratio of the exciting agent to the peroxide is 0.6: 1, the weight ratio of linear alkylbenzene sulfonate to activator is 0.05: 1.
the peroxide is percarbonate, the percarbonate is sodium percarbonate, the sodium percarbonate is coated sodium percarbonate with the particle size of 20-40 meshes, and is purchased from Jinjiangjin peroxide GmbH.
The activating agent is pentaacetylglucose and sodium nonanoylbenzene sulfonate, and the weight ratio of the activating agent to the activating agent is 1: 8; the pentaacetylglucose is beta-pentaacetylglucose.
The excitant is sodium citrate, and the sodium citrate is sodium citrate dihydrate.
The linear alkyl benzene sulfonate is linear alkyl benzene sodium sulfonate, the carbon number of an alkyl chain is 11, and the CAS: 27636-75-5.
The preparation method of the compound solid fumigation disinfectant comprises the following steps: mixing peroxide, activator, excitant and linear alkyl benzene sulfonate, and pressing to obtain the final product.
The application method of the compound solid fumigation disinfectant comprises the following steps: heating the compound solid fumigation disinfectant at 65 ℃ while ultrasonically vibrating.
Example 4
Embodiment 4 of the present invention provides a compound solid fumigation disinfectant, which is composed of peroxide, an activator and linear alkyl benzene sulfonate; the weight ratio of the peroxide to the activator is 1: 1.2, the weight ratio of the exciting agent to the peroxide is 0.6: 1, the weight ratio of linear alkylbenzene sulfonate to activator is 0.05: 1.
the peroxide is percarbonate, the percarbonate is sodium percarbonate, the sodium percarbonate is coated sodium percarbonate with the particle size of 20-40 meshes, and is purchased from Jinjiangjin peroxide GmbH.
The activating agent is pentaacetylglucose; the pentaacetylglucose is beta-pentaacetylglucose.
The excitant is sodium citrate, and the sodium citrate is sodium citrate dihydrate.
The linear alkyl benzene sulfonate is linear alkyl benzene sodium sulfonate, the carbon number of an alkyl chain is 11, and the CAS: 27636-75-5.
The preparation method of the compound solid fumigation disinfectant comprises the following steps: mixing peroxide, activator, excitant and linear alkyl benzene sulfonate, and pressing to obtain the final product.
The application method of the compound solid fumigation disinfectant comprises the following steps: heating the compound solid fumigation disinfectant at 65 ℃ while ultrasonically vibrating.
Example 5
Embodiment 5 of the present invention provides a compound solid fumigation disinfectant, which is composed of peroxide, an activator and linear alkyl benzene sulfonate; the weight ratio of the peroxide to the activator is 1: 1.2, the weight ratio of the exciting agent to the peroxide is 0.6: 1, the weight ratio of linear alkylbenzene sulfonate to activator is 0.05: 1.
the peroxide is percarbonate, the percarbonate is sodium percarbonate, the sodium percarbonate is coated sodium percarbonate with the particle size of 20-40 meshes, and is purchased from Jinjiangjin peroxide GmbH.
The activating agent is sodium nonanoylbenzene sulfonate.
The excitant is sodium citrate, and the sodium citrate is sodium citrate dihydrate.
The linear alkyl benzene sulfonate is linear alkyl benzene sodium sulfonate, the carbon number of an alkyl chain is 11, and the CAS: 27636-75-5.
The preparation method of the compound solid fumigation disinfectant comprises the following steps: mixing peroxide, activator, excitant and linear alkyl benzene sulfonate, and pressing to obtain the final product.
The application method of the compound solid fumigation disinfectant comprises the following steps: heating the compound solid fumigation disinfectant at 65 ℃ while ultrasonically vibrating.
Example 6
Embodiment 6 of the present invention provides a compound solid fumigation disinfectant, which is composed of peroxide, an activator and linear alkyl benzene sulfonate; the weight ratio of the peroxide to the activator is 1: 1.2, the weight ratio of the exciting agent to the peroxide is 0.6: 1, the weight ratio of linear alkylbenzene sulfonate to activator is 0.05: 1.
the peroxide is percarbonate, the percarbonate is sodium percarbonate, the sodium percarbonate is coated sodium percarbonate with the particle size of 20-40 meshes, and is purchased from Jinjiangjin peroxide GmbH.
The activating agent is pentaacetylglucose and sodium nonanoylbenzene sulfonate, and the weight ratio of the activating agent to the activating agent is 1: 8; the pentaacetylglucose is alpha-pentaacetylglucose.
The excitant is sodium citrate, and the sodium citrate is sodium citrate dihydrate.
The linear alkyl benzene sulfonate is linear alkyl benzene sodium sulfonate, the carbon number of an alkyl chain is 11, and the CAS: 27636-75-5.
The preparation method of the compound solid fumigation disinfectant comprises the following steps: mixing peroxide, activator, excitant and linear alkyl benzene sulfonate, and pressing to obtain the final product.
The application method of the compound solid fumigation disinfectant comprises the following steps: heating the compound solid fumigation disinfectant at 65 ℃ while ultrasonically vibrating.
Example 7
Embodiment 7 of the present invention provides a composite solid fumigation disinfectant, which is composed of peroxide, an activator and linear alkyl benzene sulfonate; the weight ratio of the peroxide to the activator is 1: 1.2, the weight ratio of the exciting agent to the peroxide is 0.6: 1, the weight ratio of linear alkylbenzene sulfonate to activator is 0.05: 1.
the peroxide is percarbonate, the percarbonate is sodium percarbonate, the sodium percarbonate is coated sodium percarbonate with the particle size of 20-40 meshes, and is purchased from Jinjiangjin peroxide GmbH.
The activator is tetraacetylethylenediamine.
The excitant is sodium citrate, and the sodium citrate is sodium citrate dihydrate.
The linear alkyl benzene sulfonate is linear alkyl benzene sodium sulfonate, the carbon number of an alkyl chain is 11, and the CAS: 27636-75-5.
The preparation method of the compound solid fumigation disinfectant comprises the following steps: mixing peroxide, activator, excitant and linear alkyl benzene sulfonate, and pressing to obtain the final product.
The application method of the compound solid fumigation disinfectant comprises the following steps: heating the compound solid fumigation disinfectant at 65 ℃ while ultrasonically vibrating.
Example 8
Embodiment 8 of the present invention provides a compound solid fumigation disinfectant, which is composed of peroxide, an activator and linear alkyl benzene sulfonate; the weight ratio of the peroxide to the activator is 1: 1.2, the weight ratio of the exciting agent to the peroxide is 0.6: 1, the weight ratio of linear alkylbenzene sulfonate to activator is 0.05: 1.
the peroxide is percarbonate, the percarbonate is sodium percarbonate, the sodium percarbonate is coated sodium percarbonate with the particle size of 20-40 meshes, and is purchased from Jinjiangjin peroxide GmbH.
The activating agent is pentaacetylglucose and sodium nonanoylbenzene sulfonate, and the weight ratio of the activating agent to the activating agent is 1: 8; the pentaacetylglucose is beta-pentaacetylglucose.
The excitant is sodium citrate, and the sodium citrate is sodium citrate pentahydrate.
The linear alkyl benzene sulfonate is linear alkyl benzene sodium sulfonate, the carbon number of an alkyl chain is 11, and the CAS: 27636-75-5.
The preparation method of the compound solid fumigation disinfectant comprises the following steps: mixing peroxide, activator, excitant and linear alkyl benzene sulfonate, and pressing to obtain the final product.
The application method of the compound solid fumigation disinfectant comprises the following steps: heating the compound solid fumigation disinfectant at 65 ℃ while ultrasonically vibrating.
Example 9
Embodiment 9 of the present invention provides a composite solid fumigation disinfectant, which is composed of peroxide, an activator and linear alkyl benzene sulfonate; the weight ratio of the peroxide to the activator is 1: 1.2, the weight ratio of the exciting agent to the peroxide is 0.6: 1, the weight ratio of linear alkylbenzene sulfonate to activator is 0.05: 1.
the peroxide is percarbonate, the percarbonate is sodium percarbonate, the sodium percarbonate is coated sodium percarbonate with the particle size of 20-40 meshes, and is purchased from Jinjiangjin peroxide GmbH.
The activating agent is pentaacetylglucose and sodium nonanoylbenzene sulfonate, and the weight ratio of the activating agent to the activating agent is 1: 8; the pentaacetylglucose is beta-pentaacetylglucose.
The excitant is sodium citrate, and the sodium citrate is sodium citrate dihydrate.
The linear alkyl benzene sulfonate is linear alkyl benzene sodium sulfonate, the carbon number of an alkyl chain is 8, and the linear alkyl benzene sulfonate is 4-n-octyl benzene sodium sulfonate.
The preparation method of the compound solid fumigation disinfectant comprises the following steps: mixing peroxide, activator, excitant and linear alkyl benzene sulfonate, and pressing to obtain the final product.
The application method of the compound solid fumigation disinfectant comprises the following steps: heating the compound solid fumigation disinfectant at 65 ℃ while ultrasonically vibrating.
Example 10
Embodiment 10 of the present invention provides a compound solid fumigation disinfectant, which is composed of peroxide, an activator and linear alkyl benzene sulfonate; the weight ratio of the peroxide to the activator is 1: 1.2, the weight ratio of the exciting agent to the peroxide is 0.6: 1, the weight ratio of linear alkylbenzene sulfonate to activator is 0.05: 1.
the peroxide is percarbonate, the percarbonate is sodium percarbonate, the sodium percarbonate is coated sodium percarbonate with the particle size of 20-40 meshes, and is purchased from Jinjiangjin peroxide GmbH.
The activating agent is tetraacetylethylenediamine and sodium nonanoylbenzenesulfonate, and the weight ratio of the activating agent to the activating agent is 1: 8.
the excitant is sodium citrate, and the sodium citrate is sodium citrate dihydrate.
The linear alkyl benzene sulfonate is linear alkyl benzene sodium sulfonate, the carbon number of an alkyl chain is 11, and the CAS: 27636-75-5.
The preparation method of the compound solid fumigation disinfectant comprises the following steps: mixing peroxide, activator, excitant and linear alkyl benzene sulfonate, and pressing to obtain the final product.
The application method of the compound solid fumigation disinfectant comprises the following steps: heating the compound solid fumigation disinfectant at 65 ℃ while ultrasonically vibrating.
Performance evaluation
1. Release rate of hydrogen peroxide: the hydrogen peroxide release rates of the formulated solid fumigants obtained in examples 1-10 were tested separately by: placing the equivalent compound solid fumigation disinfectant obtained in the embodiments 1-10 in a closed space, heating the compound solid fumigation disinfectant at 65 ℃ while performing ultrasonic treatment, and recording the time until the concentration of hydrogen peroxide reaches the maximum value in the closed space within 1.5min as first-level; the time is 1.5-3min, and the record is two-stage; the time is more than 3min, and the record is three-level.
2. Storage stability: the compound solid fumigants obtained in examples 1 to 10 were placed in an environment at 25 ℃ and 75% humidity for one week, and whether the compound solid fumigant caked or not was recorded.
3. The sterilization effect is as follows: respectively testing the sterilization effect of the compound solid fumigation disinfectant obtained in the embodiments 1 to 10, respectively placing an equal amount of the compound solid fumigation disinfectant in a closed space, suspending a bacterial tablet containing escherichia coli (8099), staphylococcus aureus (ATCC6538) and candida albicans (ATCC10231) in the closed space, respectively heating the compound solid fumigation disinfectant obtained in the embodiments 1 to 10 at 65 ℃ while carrying out ultrasonic vibration, respectively recording the number of viable bacteria after 45min, and calculating the sterilization rate, wherein the sterilization rates of the escherichia coli (8099), the staphylococcus aureus (ATCC6538) and the candida albicans (ATCC10231) are all more than 99% and are marked as excellent; the sterilization rates of escherichia coli (8099), staphylococcus aureus (ATCC6538) and candida albicans (ATCC10231) are 95-99%, and the sterilization rates are marked as good; others are noted as poor.
TABLE 1
Figure BDA0002719478800000121
The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.

Claims (10)

1. A compound solid fumigation disinfectant is characterized by comprising peroxide and an activator, wherein the weight ratio of the peroxide to the activator is 1: (1-1.5).
2. The compound solid fumigant of claim 1, wherein the peroxide is selected from one or more of urea peroxide, percarbonate, perborate, perphosphate, persilicate.
3. The compound solid fumigant of claim 2, wherein the percarbonate is coated percarbonate having a particle size of 20-40 mesh.
4. The compound solid fumigant of claim 3, wherein the activator is selected from one or more of tetraacetyl ethylenediamine, aspirin, tetraacetyl glycoluril, tetraacetyl aldopentose, pentaacetyl glucose, sodium nonanoylbenzenesulfonate.
5. The compound solid fumigant of claim 4, wherein the activator comprises pentaacetylglucose and sodium nonanoylbenzenesulfonate; the pentaacetylglucose is alpha-pentaacetylglucose and/or beta-pentaacetylglucose.
6. The compound solid fumigant of claim 5, wherein the weight ratio of pentaacetylglucose to sodium nonanoylbenzenesulfonate is 1: (6-10).
7. The compound solid fumigant of any one of claims 1-6, wherein the compound solid fumigant further comprises a trigger selected from one or more of citric acid, sodium citrate, and carbonate.
8. The compound solid fumigant disinfectant of claim 7, wherein the sodium citrate is sodium citrate dihydrate and/or sodium citrate pentahydrate.
9. The compound solid fumigant of any one of claims 1-6, wherein the compound solid fumigant further comprises linear alkyl benzene sulfonate with an alkyl chain carbon number of 9-12.
10. A method of using a composite solid fumigant of any one of claims 1 to 9, comprising: heating the compound solid fumigation disinfectant at 60-70 ℃ while ultrasonically vibrating.
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CN105685095A (en) * 2016-03-22 2016-06-22 山东威高药业股份有限公司 Endoscope disinfection sterilizing agent and application of endoscope disinfection sterilizing agent
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CN107875425A (en) * 2017-11-27 2018-04-06 中国人民解放军陆军防化学院 The sterilization method of facility inner space
CN108064879A (en) * 2017-11-27 2018-05-25 中国人民解放军陆军防化学院 The application method of Compositional type solid fumigant
CN110463720A (en) * 2018-05-09 2019-11-19 朱江 A kind of antiseptic sterilization agent of suitable endoscopy disinfection sterilizing
CN111345316A (en) * 2020-04-30 2020-06-30 浙江施维康生物医学材料有限公司 Disinfectant containing hydrogen peroxide silver ions and preparation method thereof
CN111387189A (en) * 2020-03-27 2020-07-10 成都汉凰生物技术有限公司 Disinfectant composition

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101803612A (en) * 2010-04-09 2010-08-18 中国人民解放军防化指挥工程学院 Solid binary peroxy acid disinfectant
CN105685095A (en) * 2016-03-22 2016-06-22 山东威高药业股份有限公司 Endoscope disinfection sterilizing agent and application of endoscope disinfection sterilizing agent
CN105724381A (en) * 2016-03-22 2016-07-06 山东威高药业股份有限公司 Peroxyacetic acid sterilizing liquid
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