CN112125933B - Novel Pt (IV) complex based on oxaliplatin and preparation method and application thereof - Google Patents

Novel Pt (IV) complex based on oxaliplatin and preparation method and application thereof Download PDF

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CN112125933B
CN112125933B CN202011039251.2A CN202011039251A CN112125933B CN 112125933 B CN112125933 B CN 112125933B CN 202011039251 A CN202011039251 A CN 202011039251A CN 112125933 B CN112125933 B CN 112125933B
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刘其星
丛艳伟
谢丽娇
王应飞
张林涛
陈红娟
郭明里
曹先可
张应刚
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Kunming Guiyan Pharmaceutical Co ltd
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Abstract

The invention discloses a novel Pt (IV) complex based on oxaliplatin, a preparation method and application thereof, and belongs to the field of pharmaceutical chemical synthesis. The preparation method comprises the steps of taking oxaliplatin, hydrogen peroxide and mycophenolic acid as raw materials, and oxidizing the oxaliplatin by oxidation hydrogen to form dihydroxy oxaliplatin (IV); carrying out esterification reaction on dihydroxyoxaliplatin (IV) with TBTU, triethylamine and mycophenolic acid in a DMF (dimethyl formamide) solvent to obtain a novel Pt (IV) complex mother liquor; and carrying out back-precipitation on the mother liquor by using methanol, acetone or diethyl ether to obtain the novel Pt (IV) complex. The novel Pt (IV) complex prepared by the invention has certain antitumor activity and can be used for preparing an orally-taken antitumor drug with targeting. The preparation method is simple and easy to operate, and has the characteristics of mild reaction conditions, high purity, good stability, high yield and the like.

Description

Novel Pt (IV) complex based on oxaliplatin and preparation method and application thereof
Technical Field
The invention relates to a novel Pt (IV) complex based on oxaliplatin, a preparation method and application thereof, and belongs to the field of pharmaceutical chemical synthesis.
Background
Cancer is a high-risk disease with the fatality rate at the first three in China, and chemotherapy is a diagnosis method which is common in cancer treatment, less harmful to human bodies and quick in effect. Among the chemotherapy drugs used in clinic, platinum drugs have the advantages of outstanding anti-tumor effect, wide anti-cancer spectrum, economy and the like and are applied to the treatment of various cancers. At present, platinum anticancer drugs on the market are divalent platinum complexes, all have the defects of large toxic and side effects, drug resistance, dose limitation, injection administration only and the like, and in order to improve the medical quality of patients, a series of tetravalent platinum complexes with the advantages of low toxicity, oral administration, targeting effect and the like are developed successively. The tetravalent platinum complex is formed by grafting ligands with different or same effects on the axial direction of the divalent platinum complex, so that the novel platinum complex not only has better water solubility, fat solubility and targeting property, but also has the specific function of the ligands.
Studies already show that mycophenolic acid has the effects of resisting tumor angiogenesis and tumors and is a potential therapeutic drug for inhibiting the growth and metastasis of osteosarcoma; mycophenolate mofetil is a commonly used immunosuppressant, is widely applied to rheumatic diseases such as lupus erythematosus, vasculitis, myositis, dermatomyositis and the like, can also effectively control the occurrence of organ transplant rejection, and is also applied to organ transplantation. Based on the excellent medical efficacy of mycophenolic acid, the mycophenolic acid is organically combined with oxaliplatin oxide to form a novel Pt (IV) complex which is expected to exert antitumor activity on a certain specific cancer cell and retain the antitumor advantages of tetravalent platinum and platinum drugs.
Disclosure of Invention
The first purpose of the invention is to provide a novel Pt (IV) complex (MPAO-Pt (IV)) based on oxaliplatin, the second purpose of the invention is to provide a preparation method of the novel Pt (IV) complex based on the oxaliplatin, and the third purpose of the invention is to provide the application of the novel Pt (IV) complex based on the oxaliplatin in preparing anti-tumor drugs.
The novel Pt (IV) complex prepared by the method has the characteristics of simple synthesis method, easy operation, mild reaction conditions, high purity, good stability, high yield and the like.
The technical scheme adopted for realizing the purpose of the invention is as follows:
a novel Pt (IV) complex based on oxaliplatin is characterized by the following structure:
Figure BDA0002706074290000021
a preparation method of a novel Pt (IV) complex based on oxaliplatin comprises the following steps:
(1) adding oxaliplatin into water, stirring uniformly, adding 30% hydrogen peroxide, stirring in a dark place, filtering, washing and drying to obtain dihydroxyoxaliplatin (IV);
(2) dissolving the product in DMF, adding TBTU, triethylamine and mycophenolic acid, stirring in the dark, and filtering to obtain a novel Pt (IV) complex mother liquor;
(3) adding methanol or ethanol into the mother liquor, concentrating, adding an anti-precipitation solvent into the residual liquid in a dark environment, and fully stirring, filtering, washing and drying to obtain the novel Pt (IV) complex.
Preferably, in the step (1): the water temperature and the stirring temperature are 50-70 ℃; the adding speed of the hydrogen peroxide solution is 0.1-0.4 mL per second; stirring for 4-8 h in a dark place; the drying temperature is 60-80 ℃; the drying time is 6-8 h.
Preferably, in the step (1): the mass ratio of the oxaliplatin to the water is 1; the mass volume ratio of the oxaliplatin to the 30% hydrogen peroxide is 1; the volume ratio of the 30% hydrogen peroxide to the water is 1.
Preferably, in the step (2): the mass volume ratio of the dihydroxyoxaliplatin (IV) to the DMF is 1; the molar ratio of dihydroxyoxaliplatin (IV) to any one of TBTU, triethylamine and mycophenolic acid is 1; adding TBTU, triethylamine and mycophenolic acid, and stirring for 60-80 h in the dark.
Preferably, in the step (3): the volume ratio of DMF to methanol or ethanol is 1-5; the anti-precipitation solvent is a mixture of any two solvents of methanol, acetone or diethyl ether, and the volume ratio of any two solvents is 1; the volume ratio of the residual liquid after concentration to the back-elution solvent is 1; the water bath temperature of the rotary evaporator is 50-70 ℃; the vacuum degree of the rotary evaporator is 250-200 hPa/mbar; the vacuum drying temperature is 20-50 ℃; the vacuum drying time is 4-8 h.
Application of a novel Pt (IV) complex based on oxaliplatin in preparation of anti-tumor drugs.
Application of novel Pt (IV) complex based on oxaliplatin in preparation of orally-administrable medicament with targeted antitumor effect.
Further, the tumor includes lung cancer, breast cancer, liver cancer and colon cancer.
The invention has the advantages of
According to the preparation method, oxaliplatin, hydrogen peroxide and mycophenolic acid are used as raw materials, oxaliplatin is oxidized to dihydroxy oxaliplatin, and then the dihydroxy oxaliplatin is subjected to esterification reaction with TBTU, triethylamine and mycophenolic acid in a DMF solvent to obtain the novel Pt (IV) complex. The novel Pt (IV) complex is respectively connected with mycophenolic acid ligands with targeting effects at two axial ends of Pt, so that the novel Pt (IV) complex has good lipophilicity, and shows anti-tumor activity superior to that of the existing cisplatin, carboplatin and oxaliplatin for certain cancer cells, and therefore, the novel Pt (IV) complex can become a novel oral specific medicine with targeting effects in the future. In addition, the novel Pt (IV) complex synthesized by the method has the characteristics of simple synthesis, easy operation, mild reaction conditions, high product purity, good stability, high yield and the like.
Drawings
FIG. 1 shows a synthetic route of a novel Pt (IV) complex.
FIG. 2 is a mass spectrum of a novel Pt (IV) complex.
FIG. 3 is a nuclear magnetic hydrogen spectrum of a novel Pt (IV) complex.
Detailed Description
The present invention will be described in further detail with reference to examples, but the scope of the present invention is not limited to the examples.
Example 1
A preparation method of a novel Pt (IV) complex based on oxaliplatin specifically comprises the following operations:
(1) Synthesis of dihydroxyoxaliplatin (IV)
Adding 1.0 part of oxaliplatin into 50 ℃ water, stirring for 1min at 50 ℃, adding 0.1mL of hydrogen peroxide solution per second, stirring for 4h in a dark place, filtering, washing with proper amount of water for 3 times, draining, and drying for 8h at 60 ℃ to obtain 1.01g of dihydroxyoxaliplatin (IV), wherein the yield is 92.7%. Wherein, the preparation method of the oxaliplatin comprises the following steps that water is 1g and 50mL, the oxaliplatin is 30% hydrogen peroxide and is 1g and 0.8mL, and the preparation method of the hydrogen peroxide solution comprises the following steps: 30% hydrogen peroxide was added to 5 volumes of water and stirred.
(2) Process for preparing mother liquor of Pt (IV) complex
DMF was removed according to a mass volume ratio of dihydroxyoxaliplatin (iv) to DMF of 1g. Adding dihydroxyoxaliplatin (IV) into DMF at 20 ℃, stirring for 10min at 20 ℃, filtering, transferring the filtrate to an environment at 20 ℃, adding TBTU, triethylamine and mycophenolic acid, stirring for 60h in the dark, filtering, and collecting the filtrate.
(3) Process for preparing Pt (IV) complex finished product
Removing methanol or ethanol according to a volume ratio of DMF to methanol or ethanol of 1. Adding methanol or ethanol into the filtrate collected in the step (2), stirring uniformly, evaporating the mixed solution by using a rotary evaporator until no liquid drops drop (the water bath temperature is 50 ℃, the vacuum degree is 250 hPa/mbar), taking out the residual liquid, adding a reverse precipitation solvent in a dark environment, stirring for 10min at 20 ℃, filtering, stirring and washing the filter cake for 3 times by using a proper amount of water at 0 ℃, filtering, drying in vacuum at 20 ℃ for 4h to obtain 2.21g of a novel Pt (IV) complex, wherein the comprehensive yield (calculated by oxaliplatin) is 84.7%.
Example 2
A preparation method of a novel Pt (IV) complex based on oxaliplatin specifically comprises the following operations:
(1) Synthesis of dihydroxyoxaliplatin (IV)
Adding 50.0 parts of oxaliplatin into 60 ℃ water, stirring for 15min at 60 ℃, adding 0.2mL of hydrogen peroxide solution per second, stirring for 6h in a dark place, filtering, washing with proper amount of water for 3 times, draining, and drying for 7h at 70 ℃ to obtain 51.93g of dihydroxyoxaliplatin (IV), wherein the yield is 95.6%. Wherein, the ratio of oxaliplatin to water is 1g and is 80mL, the ratio of oxaliplatin to 30% hydrogen peroxide is 1g and is 1.0mL, and the preparation method of the hydrogen peroxide solution comprises the following steps: 30% hydrogen peroxide was added to 8 times the volume of water and stirred.
(2) Process for preparing mother liquor of Pt (IV) complex
The mass volume ratio of dihydroxyoxaliplatin (iv) to DMF of 1 g/6 ml was transferred to DMF, and TBTU, triethylamine and mycophenolic acid were weighed according to the molar ratio of dihydroxyoxaliplatin (iv) to TBTU, triethylamine and mycophenolic acid of 1. Adding dihydroxyoxaliplatin (IV) into DMF at 30 ℃, stirring for 20min at 30 ℃, filtering, transferring the filtrate to an environment at 30 ℃, adding TBTU, triethylamine and mycophenolic acid, stirring for 70h in the dark, filtering, and collecting the filtrate.
(3) Process for preparing Pt (IV) complex finished product
Removing methanol or ethanol according to a volume ratio of DMF to methanol or ethanol of 1. Adding methanol or ethanol into the filtrate collected in the step (2), stirring uniformly, evaporating the mixed solution by using a rotary evaporator until no liquid drops drop (the water bath temperature is 60 ℃, the vacuum degree is 230 hPa/mbar), taking out the residual liquid, adding a reverse precipitation solvent in a dark environment, stirring for 30min at 30 ℃, filtering, stirring and washing the filter cake for 3 times by using a proper amount of water at 10 ℃, filtering, drying at 30 ℃ in vacuum for 6h to obtain 112.62g of the novel Pt (IV) complex, wherein the comprehensive yield (calculated by oxaliplatin) is 86.3%.
Example 3
A preparation method of a novel Pt (IV) complex based on oxaliplatin specifically comprises the following operations:
(1) Synthesis of dihydroxyoxaliplatin (IV)
Adding 100.0 parts of oxaliplatin into 70 ℃ water, stirring the mixture for 30min at 70 ℃, adding 0.4mL of hydrogen peroxide solution per second, stirring the mixture for 8h in a dark place, filtering the mixture, washing the mixture for 3 times by using proper amount of water, draining the mixture, and drying the mixture for 6h at 80 ℃ to obtain 99.91g of dihydroxyoxaliplatin (IV), wherein the yield is 92.0%. Wherein, the ratio of oxaliplatin to water is 1g: 30% hydrogen peroxide was added to 10 volumes of water and stirred.
(2) Process for preparing mother liquor of Pt (IV) complex
DMF was removed at a mass to volume ratio of dihydroxyoxaliplatin (iv) to DMF of 1g, and TBTU, triethylamine and mycophenolic acid were weighed at a molar ratio of dihydroxyoxaliplatin (iv) to TBTU, triethylamine and mycophenolic acid of 1. Adding dihydroxyoxaliplatin (IV) into DMF at 40 ℃, stirring for 30min at 40 ℃, filtering, transferring the filtrate to the environment at 40 ℃, additionally adding TBTU, triethylamine and mycophenolic acid, stirring for 80h in dark, filtering, and collecting the filtrate.
(3) Process for preparing Pt (IV) complex finished product
Removing the methanol or the ethanol according to a volume ratio of the DMF to the methanol or the ethanol of 1. Adding methanol or ethanol into the filtrate collected in the step (2), stirring uniformly, evaporating the mixed solution by using a rotary evaporator until no liquid drops drop (the water bath temperature is 70 ℃, the vacuum degree is 200 hPa/mbar), taking out the residual liquid, adding a reverse precipitation solvent in a dark environment, stirring for 60min at 40 ℃, filtering, stirring and washing the filter cake for 3 times by using a proper amount of water at 20 ℃, filtering, drying at 50 ℃ in vacuum for 8h to obtain 225.62g of a novel Pt (IV) complex, wherein the comprehensive yield (calculated by oxaliplatin) is 86.5%.
From the results, the method for preparing the novel Pt (IV) complex has the advantages of simple operation, stable yield and high yield, so the process is more suitable for mass production.
As shown in fig. 2, the mass spectrum of the novel Pt (iv) complex obtained in example 2 shows:
HR-MS(m/z):[C 42 H 52 N 2 O 16 Pt+Na] + =1058.3 (100%), 1059.3 (94.6%), 1057.3 (63.2%), 1060.3 (37.7%), 1061.3 (21.9%), 1062.3 (11.6%), consistent with the molecular weight of the target compound.
As shown in fig. 3, which is a nuclear magnetic hydrogen spectrum diagram of the novel Pt (iv) complex, it can be seen that:
1 H-NMR(400MHz,DMSO):δ(ppm)=9.36~9.37(s,2H,2C-OH),8.20~8.31(d, 4H,2COO-CH 2 ),5.24(s,4H,2CH-CH 2 ),5.11~5.13(t,2H,2CH-NH 2 ),3.69(s,6H, 2CO-CH 3 ),3.27~3.28(d,4H,2CO-CH 2 ),2.28~2.31(t,4H,2C-CH 2 ),2.09~2.11(t, 4H,2CH-CH 2 ),2.07~2.08(s,6H,2C-CH 3 ),1.70(s,6H,2C-CH 3 ),1.47~1.48(s,2H, 2C-CH),1.23~1.38(d,4H,2NH 2 ),1.08~1.18(m,4H,2CH 2 -CH 2 ) Groups of hydrogen signals assigned to the target compound C 42 H 52 N 2 O 16 The Pt hydrogen spectrum signals belong to the same category, which shows that the product prepared by the method is the target product, and the spectrum only contains trace impurity peaks, thus showing that the purity of the prepared product is higher.
Table 1 shows the IC of novel Pt (IV) complexes based on oxaliplatin in various cancer cells 50 Value (. Mu.M). The novel Pt (IV) complex prepared by the invention is tested for in-vitro antitumor activity on human lung cancer cells A549, human breast cancer cells MCF-7, human liver cancer cells HEPG-2 and human colon cancer cells SW480 by adopting an MTT method, cisplatin and satraplatin are selected as positive controls, and the half maximum inhibition concentration (IC 50) of the novel Pt (IV) complex in 48 hours is shown in the table.
TABLE 1 IC of the above novel Pt (IV) complexes with cisplatin and satraplatin in various cancer cells 50 Value comparison table
Figure BDA0002706074290000071
The results in Table 1 show that the complex has far better inhibitory activity on HEPG-2 and SW480 tumor cell lines than cisplatin but slightly lower than satraplatin, and shows potential application prospects on two tumor cells.

Claims (10)

1. An oxaliplatin-based Pt (IV) complex is characterized by having the following structure:
Figure 863949DEST_PATH_IMAGE001
2. a method for preparing oxaliplatin-based Pt (iv) complex according to claim 1, characterized by comprising the steps of:
step 1, synthesizing dihydroxyoxaliplatin (IV): adding oxaliplatin into water, stirring uniformly, adding 30% hydrogen peroxide, stirring in a dark place, filtering, washing and drying to obtain dihydroxyoxaliplatin (IV);
step 2, preparing a Pt (IV) complex mother solution: dissolving the dihydroxyoxaliplatin (IV) product in DMF, adding TBTU, triethylamine and mycophenolic acid, stirring in a dark place, and filtering to obtain a Pt (IV) complex mother solution;
step 3, preparing a Pt (IV) complex finished product: adding methanol or ethanol into the Pt (IV) complex mother liquor, concentrating, adding a reverse precipitation solvent into the residual liquid after concentrating in a dark environment, stirring for 10 to 60min at 20 to 40 ℃, filtering, stirring and washing a filter cake for 3 times with a proper amount of water at 0 to 20 ℃, filtering, and drying in vacuum for 4 to 8h at 20 to 50 ℃ to obtain the Pt (IV) complex.
3. The method for preparing oxaliplatin-based Pt (IV) complex as claimed in claim 2, wherein the step 1 of dihydroxyoxaliplatin (IV) synthesis comprises:
adding 1.0 to 100.0g of oxaliplatin into water at a temperature of between 40 and 80 ℃, stirring for 1 to 30min at a temperature of between 50 and 70 ℃, adding a hydrogen peroxide solution at a speed of 0.1 to 0.4mL per second, stirring for 4 to 8h in the dark, filtering, washing for 3 times by using appropriate amount of water, filtering, drying, and drying for 6 to 8h at a temperature of between 60 and 80 ℃.
4. A method for the preparation of oxaliplatin-based Pt (IV) complexes according to claim 3, characterized in that:
the mass volume ratio of oxaliplatin to water is 1g: adding 30% hydrogen peroxide into water with the volume of 5 to 10 times of the volume of the water, and uniformly stirring.
5. The method for preparing oxaliplatin-based Pt (IV) complex according to claim 2, wherein the step 2 of preparing the Pt (IV) complex mother liquor comprises:
adding dihydroxyoxaliplatin (IV) into DMF at the temperature of 20-40 ℃, stirring for 10-30min at the temperature of 20-40 ℃, filtering, transferring the filtrate into the environment at the temperature of 20-40 ℃, adding TBTU, triethylamine and mycophenolic acid, stirring for 60-80h in the dark, filtering, and collecting the filtrate;
the mass volume ratio of the dihydroxyoxaliplatin (IV) to the DMF is 1g to 8mL;
the molar ratio of the dihydroxyoxaliplatin (IV) to any one of TBTU, triethylamine and mycophenolic acid is 1.
6. The method for preparing oxaliplatin-based Pt (IV) complexes according to claim 2, characterized in that:
the volume ratio of the DMF to the methanol or the ethanol is 1 to 5;
the volume ratio of the back-separation solvent to the residual liquid after concentration is 5 to 10.
7. A method for the preparation of oxaliplatin-based Pt (IV) complexes according to claim 2 or 6, characterized in that:
the anti-precipitation solvent is a mixture of any two solvents of methanol, acetone or diethyl ether, and the volume ratio of any two solvents is 1.
8. Use of oxaliplatin-based Pt (IV) complexes according to claim 1 for the preparation of anti-tumour medicaments.
9. Use of oxaliplatin-based Pt (IV) complexes according to claim 1 for the preparation of an oral medicament with targeted anti-tumor properties.
10. Use of oxaliplatin-based Pt (IV) complexes according to claim 8 or use of oxaliplatin-based Pt (IV) complexes according to claim 9 for the preparation of an oral medicament with a targeted anti-tumor effect, characterized in that:
the tumor is liver cancer and colon cancer.
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Citations (1)

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Publication number Priority date Publication date Assignee Title
CN105622674A (en) * 2016-02-29 2016-06-01 东南大学 Tetravalent platinum complex with bioactive group and preparation method of tetravalent platinum complex

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Publication number Priority date Publication date Assignee Title
CN105622674A (en) * 2016-02-29 2016-06-01 东南大学 Tetravalent platinum complex with bioactive group and preparation method of tetravalent platinum complex

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