CN112089508A - Anti-migration aortic valve stent - Google Patents

Anti-migration aortic valve stent Download PDF

Info

Publication number
CN112089508A
CN112089508A CN202010883633.7A CN202010883633A CN112089508A CN 112089508 A CN112089508 A CN 112089508A CN 202010883633 A CN202010883633 A CN 202010883633A CN 112089508 A CN112089508 A CN 112089508A
Authority
CN
China
Prior art keywords
valve
shaped
module
support module
unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN202010883633.7A
Other languages
Chinese (zh)
Other versions
CN112089508B (en
Inventor
申祥
鲁凯凯
�田润
李函青
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu University
Original Assignee
Jiangsu University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu University filed Critical Jiangsu University
Priority to CN202010883633.7A priority Critical patent/CN112089508B/en
Publication of CN112089508A publication Critical patent/CN112089508A/en
Application granted granted Critical
Publication of CN112089508B publication Critical patent/CN112089508B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418—Scaffolds therefor, e.g. support stents

Landscapes

  • Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

The invention provides an anti-migration aortic valve stent, which comprises a valve stent main body, a valve sewing section and wing-shaped knots, wherein the valve stent main body is provided with a plurality of valve sewing sections; the valve support main part includes continuous distal end and proximal end, and distal end and proximal end all include at least three support module, and a plurality of wing knots of buckling outwards are radial in the circumference of valve support main part and are used for contacting with the valve ring, have anti migration function, have reduced aortic valve support and implanted the back because of the impact of the large blood flow and the risk that aortic valve ring department pathological change took place to migrate. In addition, the bracket adopts the idea of modular design, the circumference of the bracket main body comprises a plurality of supporting modules, and each supporting module is independent and mutually coordinated. For valve parts with serious stenosis and serious calcification, the invention improves the support performance of the stent by changing the quantity of the connecting ribs. The valve support with the modular design can be individually customized according to the pathological changes of patients.

Description

Anti-migration aortic valve stent
Technical Field
The invention belongs to the technical field of medical instruments, and particularly relates to an anti-migration aortic valve stent.
Background
Transcatheter arterial Replacement (TAVR) refers to the implantation of a prosthetic Valve stent into a lesion through a catheter to replace the diseased Valve. Compared with the traditional open type valve replacement surgery, the TAVR has the advantages of minimally invasive property and high efficiency. Therefore, the method is suitable for high-risk patients who cannot tolerate conventional open chest surgery.
The heart aortic valve is equivalent to a one-way valve in the heart, heart valve patients currently account for about 30% of heart disease patients in China, and a large number of patients need to perform heart valve replacement every year. The artificial heart valve replacement is used as a heart implantation interventional medical device for treating heart valve diseases or defects, is firstly applied to clinic in 1960, and is a very important medical device in the field of cardiovascular treatment at present. The valve stent can be divided into a mechanical valve, a biological engineering valve, an intervention valve and the like according to different materials and working principles. More of the current uses are biological tissue valves, which have good biocompatibility and hemodynamic properties compared to mechanical valves. A common problem that plagues today is the problem of axial migration during and after implantation of a valve stent. On one hand, the valve stent can generate a migration phenomenon due to low friction between the stent and an aortic valve ring in the implantation process; on the other hand, after the valve stent is implanted, the valve stent is subjected to the impact force of blood for a long time in the systole, so that the valve stent is easy to have migration behavior. The patient's life is compromised once the migration activity occurs. Therefore, a valve stent with excellent migration resistance is urgently needed.
Disclosure of Invention
In order to solve the technical problems, the invention provides an anti-migration aortic valve stent which has a good anti-migration function and adopts a modular design. The winged knot mainly comprises a connecting section and a bending section, and the bending section has an anti-migration function, so that the risk of migration caused by impact of large blood flow and pathological changes at the aortic valve annulus after the aortic valve stent is implanted is reduced. In addition, the bracket adopts the idea of modular design, the circumference of the bracket main body comprises a plurality of supporting modules, and each supporting module is independent and mutually coordinated. For valve parts with serious stenosis and serious calcification, the invention improves the support performance of the stent by changing the quantity of the connecting ribs. The valve support with the modular design can be individually customized according to the pathological changes of patients.
The technical scheme of the invention is as follows: an anti-migration aortic valve stent comprises a valve stent main body, a valve sewing section and wing-shaped knots; the valve support main body comprises a far-end and a near-end which are connected, the far-end and the near-end respectively comprise at least three supporting modules, and the supporting modules are connected through a valve sewing section; the valve is arranged in the valve support main body and is connected with the valve sewing section; each supporting module comprises two rows of unit wave bands which are arranged up and down, each row of unit wave bands comprise a plurality of V-shaped unit waves, the wave crests of the V-shaped unit waves of the two rows of unit wave bands are opposite, the peak troughs of the V-shaped unit waves at the tail ends of the two sides of the upper row of unit wave bands and the tail troughs of the V-shaped unit waves are connected, and partial or all opposite; the utility model discloses a valve support, including heart support main part, V type unit ripples of telecentric side, the V type unit ripples of lower row is equipped with wing knot respectively in the telecentric side, wing knot is the chevron shape and includes the section of can buckling at top and the linkage segment at bottom both ends, and the section of can buckling at top stretches to the crest of V type unit ripples, and the linkage segment at bottom both ends is connected with the trough of V type unit ripples, both sides between section of bending and the linkage segment are equipped with fore-and-aft recess, wing knot can bend and outwards overturn alpha degree in the recess, and a plurality of wing knots of outwards buckling are radially to be used for contacting with the valve annulus in the circumference of valve support main part.
In the scheme, the alpha is 50-60 degrees.
In the above scheme, the distal end and the proximal end both include three support modules.
Further, each row of unit wave bands of each support module comprises 3V-shaped unit waves, and the number of the wing-shaped knots is nine.
Furthermore, part of opposite wave crests in the wave bands of the upper row and the lower row of the supporting modules are connected to form an A-type supporting module; all opposite wave crests in the upper and lower rows of unit wave bands of the supporting module are connected to form a B-type supporting module; the a-type support module and the B-type support module can be combined to form different valve stent bodies.
Further, the combination of the A-type support module and the B-type support module is
Figure BDA0002654879440000021
Or
Figure BDA0002654879440000022
Figure BDA0002654879440000023
The three modules representing the far end adopt A-type supporting modules, and the three modules representing the near end adopt B-type supporting modules;
Figure BDA0002654879440000024
the three modules representing the far-end adopt a B-type support module, an A-type support module and an A-type support module, and the near-end adopts an A-type support module, an A-type support module and a B-type support module;
Figure BDA0002654879440000025
the three modules representing the far-end adopt an A-type support module, an A-type support module and a B-type support module, and the near-end adopts a B-type support module, an A-type support module and an A-type support module.
Furthermore, the peaks and valleys of the V-shaped unit waves at the extreme ends of the two sides in the upper and lower rows of unit wave bands of the A-shaped support module are connected through the fan-shaped ring, and the peaks of the middle V-shaped unit waves are connected through the S-shaped connecting rib.
Furthermore, the peaks and valleys of the V-shaped unit waves at the extreme ends of two sides in the upper row of unit wave bands and the lower row of unit wave bands of the B-type supporting module are connected through the fan-shaped rings, and the peaks of the three V-shaped unit waves are connected through the S-shaped connecting ribs.
In the scheme, the valve is made of pure polymer materials, swim bladders, porcine pericardium, bovine pericardium or high polymer materials.
In the above scheme, the wing-shaped knot is made of nickel-titanium shape memory alloy.
Compared with the prior art, the invention has the beneficial effects that: the valve support main body is of modular design, and each support module is independent from each other and can work in coordination with each other. For valve parts with serious stenosis and serious calcification, the invention improves the support performance of the stent by changing the quantity of the connecting ribs. The type of the valve support with the modular design can be flexibly changed according to the special pathological condition of a patient, and the personalized customization of the design of the valve support is realized. On the basis of the traditional support, the wing-shaped knot is skillfully designed, and the use of implanting equipment such as a catheter and the like cannot be influenced. The design purpose is completed through different structural characteristics of the valve stent before and after implantation, and the valve stent has the function of migration resistance. The valve is made of pure polymer materials, swim bladders, porcine pericardium, bovine pericardium and high polymer materials, so that the use of anticoagulant drugs by patients can be reduced to a great extent. In particular, pure polymer valves can be manufactured by mechanical automation, the valve precision and quality are better controlled, compared with the traditional valves, the pure polymer valves have the advantages of large opening area, no need of any animal tissue, excellent durability, more economical and rapid processing mode and excellent tissue compatibility, and can rapidly provide economical, safe and effective valves for many patients.
Drawings
FIG. 1 is a schematic plan view of an expanded structure of an embodiment of the present invention;
FIG. 2 is a schematic diagram of an expanded structure of an embodiment of the present invention, wherein (a) is a perspective view and (b) is a front view;
FIG. 3 is a comparison of a wing shaped knot of an embodiment of the present invention before and after expansion, wherein (a) is a pre-implantation state and (b) is a post-implantation state;
FIG. 4 is a schematic view of two support modules of the present invention, wherein (a) is a type A support module diagram and (B) is a type B support module diagram;
FIG. 5 is a schematic illustration of a service state of an embodiment of the present invention;
FIG. 6 illustrates a first embodiment of a modular design method according to an embodiment of the present invention;
FIG. 7 is a second embodiment of a modular design method according to an embodiment of the present invention;
fig. 8 shows a third embodiment of the modular design method according to the first embodiment of the present invention.
In the figure, 1, V-shaped element waves; 2. a valve sewing section; 3. a wing-shaped knot; 4. s-shaped connecting ribs; 5. a bendable section; 6. a connecting section; 7. a groove; 8. a valve; 9. an annulus; 10. autologous valve leaflets; 11. a first module; 12. a second module; 13. a third module; 14. a fourth module; 15. a fifth module; 16. and a sixth module.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are illustrative and intended to be illustrative of the invention and are not to be construed as limiting the invention.
In the description of the present invention, it is to be understood that the terms "central," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "axial," "radial," "vertical," "horizontal," "inner," "outer," and the like are used in the orientations and positional relationships indicated in the drawings for convenience in describing the present invention and for simplicity in description, and are not intended to indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and are not to be considered limiting. Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.
In the present invention, unless otherwise expressly specified or limited, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can, for example, be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
Fig. 1 shows a preferred embodiment of the anti-migration aortic valve stent, which comprises a valve stent main body, a valve 8, a valve sewing segment 2 and winged knots 3.
The valve support main body comprises a far-end and a near-end which are connected, the far-end and the near-end respectively comprise at least three supporting modules, and the supporting modules are connected through a valve sewing section 2; the valve 8 is arranged in the valve bracket main body and is connected with the valve sewing section 2.
Each supporting module comprises two rows of unit wave bands which are arranged up and down, each row of unit wave bands comprise a plurality of V-shaped unit waves 1, the wave crests of the V-shaped unit waves 1 of the two rows of unit wave bands are opposite, the peak valleys of the V-shaped unit waves 1 at the tail ends of the two sides in the upper row of unit wave bands and the tail valleys of the V-shaped unit waves 1 at the tail ends of the two sides in the lower row of unit wave bands are connected, and partial or all opposite wave crests in the upper row of unit wave.
The utility model discloses a valve support, including telecentric mirror, V type unit ripples 1, the V type unit ripples 1 of telecentric mirror lower row is equipped with wing knot 3 respectively, wing knot 3 is the chevron shape and includes the bendable section 5 at top and the linkage segment 6 at bottom both ends, and the bendable section 5 at top stretches to the crest at V type unit ripples 1, and the linkage segment 6 at bottom both ends is connected with the trough of V type unit ripples 1, both sides between section 5 and the linkage segment 6 of bending are equipped with fore-and-aft recess 7, wing knot 3 can bend and outwards overturn alpha degree in recess 7 department, and a plurality of wing knots 3 of outwards buckling are radially to be used for contacting with valve ring 9 in the circumference of valve support main part. Preferably, the alpha is 50-60 degrees.
According to this embodiment, preferably, the distal end and the proximal end each comprise three support modules; namely, the valve stent main body comprises six support modules, specifically, the distal end comprises a first support module, a second support module and a third support module; the proximal end comprises a fourth support module, a fifth support module and a sixth support module. Each row of unit wave bands of each support module comprises 3V-shaped unit waves 1, and the number of the wing-shaped knots 3 is nine.
The wave crests in the upper and lower rows of unit wave bands which are opposite to each other in the supporting module are connected to form an A-type supporting module; all opposite wave crests in the upper and lower rows of unit wave bands of the supporting module are connected to form a B-type supporting module; the A-type support module and the B-type support module are combined to form different valve support main bodies.
The local structure and function of the support in each support module are relatively independent, so that each support module is independent from each other and can work in coordination. The total number of the supporting modules is six, and the valve stent can be individually customized according to the pathological change condition of a patient. The combination of the A-type support module and the B-type support module can be
Figure BDA0002654879440000051
Or
Figure BDA0002654879440000052
Figure BDA0002654879440000053
The three modules representing the far end adopt A-type supporting modules, and the three modules representing the near end adopt B-type supporting modules;
Figure BDA0002654879440000054
the three modules representing the far-end adopt a B-type support module, an A-type support module and an A-type support module, and the near-end adopts an A-type support module, an A-type support module and a B-type support module;
Figure BDA0002654879440000055
the three modules representing the far-end adopt an A-type support module, an A-type support module and a B-type support module, and the near-end adopts a B-type support module, an A-type support module and an A-type support module.
Preferably, the A-type supporting module is designed in a mirror-image open-loop structure, peaks and valleys of V-type unit waves 1 at the extreme ends of two sides in the upper row of unit wave bands and the lower row of unit wave bands are connected through a fan-shaped ring, and peaks of middle V-type unit waves 1 are connected through an S-shaped connecting rib 4.
Preferably, the B-type supporting module is designed to be a mirror closed-loop structure, peaks and valleys of the V-type unit waves 1 at the extreme ends of two sides in the upper row of unit wave bands and the lower row of unit wave bands are connected through a fan-shaped ring, and peaks of the three V-type unit waves 1 are connected through an S-shaped connecting rib 4.
Preferably, the valve 8 is made of pure polymer material, swim bladder, porcine pericardium, bovine pericardium or high polymer material.
Preferably, said winged knot 3 is made of nickel titanium shape memory alloy.
Before expanding, the wing-shaped knots 3 and the valve support main body are on the same plane, so that the wing-shaped knots are compressed into a conveying system before expanding, and the conveying convenience is greatly improved. The wing-like knot 3 is made of nickel titanium shape memory alloy. When the stent is implanted, the wing-like knots 3 are bent at the groove 7 and turned outwards by a certain angle α, said α being between 50 and 60 degrees. Therefore, the wing-shaped knots 3 radially contact the valve ring 9 in an umbrella shape, thereby fixing the valve stent and preventing the valve stent from migrating after being implanted.
The following detailed description of the embodiments of the present invention with reference to the drawings shows the following steps:
the anti-migration aortic valve stent is designed in a modular mode and is used for replacing calcified or stenotic valves, as shown in figure 1, a preferred embodiment of the stent comprises six supporting modules which are formed by V-shaped unit waves, and S-shaped connecting ribs 4 are connected. Wherein each support module is closed so that each unit is independent of and operates in coordination with each other.
As shown in fig. 2, the implanted state of the valve stent of the present invention includes three groups of wing-shaped knots 3 and valve sewing segments 2, which are uniformly distributed in the circumferential direction of the valve stent main body and connected to the valve stent main body by laser welding, wherein the valve sewing segments 2 are preferably made of cobalt-chromium alloy or 316L with a diameter of 8 × 0.9 × 0.2mm, and 8 through holes with a diameter of 0.2-0.4mm are opened in the middle for sewing the valve 8. Before expanding, the wing-shaped knot 3 and the main body of the bracket are on the same plane, and are conveniently compressed into the conveying device.
As shown in fig. 3, a shape comparison of the wing-like knot 3 after implantation and before implantation is shown. The wing-shaped knots 3 comprise a connecting section 6 and a bending section 5, the connecting section 6 is connected with the valve support main body in a laser welding mode, the number of the wing-shaped knots is nine, and every three wing-shaped knots are uniformly fixed on the circumference of the valve support main body in a group. The bent section 5 is provided with a groove 7 with the thickness of 1 multiplied by 0.3 multiplied by 0.2mm, and when the support is implanted, the wing-shaped knot 3 is outwards turned by 50-60 degrees at the groove 7 and is in an umbrella-shaped radial shape.
As shown in fig. 4, it is a structural diagram of A, B two types of support modules in the invention, wherein, fig. 4(a) a type of support module is designed as a mirror-image open-loop structure, and includes six V-shaped unit waves 1 which are symmetrical up and down, and two ends are connected by a fan-shaped ring, and the middle is connected by only one S-shaped connecting rib 4; the B-type unit in the figure 4(B) is designed in a mirror closed-loop structure, comprises six V-type unit waves 1 which are symmetrical up and down, two ends of the V-type unit waves are connected through a fan-shaped ring, and wave crests of the V-type unit waves are connected through three S-shaped connecting ribs 4.
Fig. 5 is a schematic view of the service state of the present invention. After the support is implanted, the wing-shaped knots 3 are contacted with the valve ring 9, and the support is fixed at the valve ring 9 through the umbrella-shaped radial characteristic of the wing-shaped knots 3 after the valve support is expanded, so that the valve support is prevented from migrating.
For a better understanding of the modular design method of the present invention, the following detailed description is provided in conjunction with the accompanying drawings:
the first embodiment is as follows:
as shown in fig. 6, a first embodiment of the modular design method of the present invention is shown. Can be obtained by adopting a modular design method
Figure BDA0002654879440000061
The A-type support module is designed in a mirror image open-loop structure and comprises six V-type unit waves which are symmetrical up and down, two ends of the A-type support module are connected through a fan-shaped ring, and the middle of the A-type support module is connected through an S-shaped connector; the B-type supporting module is designed for a mirror closed loop structure, comprises six V-shaped unit waves which are symmetrical up and down, two ends of the V-shaped unit waves are connected through a fan-shaped ring, and wave crests of the V-shaped unit waves are connected through three S-shaped connectors. This type is directed to three pieces of aortic valveThe valve leaflets are heavily calcified, and the left ventricular outflow tract is not narrowed or calcified, so that the valve support part at the upper end of the valve ring needs great support strength, and the design scheme of the first scheme is adopted. Namely, the first module 11, the second module 12 and the third module 13 all adopt the structural mode of the support module A, and the fourth module 14, the fifth module 15 and the sixth module 16 all adopt the structural mode of the support module B, and are mainly in contact with calcified or lesion serious parts.
The embodiment is of modular design
Figure BDA0002654879440000062
The valve stent comprises a valve stent main body consisting of six support modules, a V-shaped unit wave 1, S-shaped connecting ribs 4 wing-shaped knots 3, a connecting section 6, a bending section 5, a groove 7 and the like. Each support module consists of a V-shaped unit wave 1 and a different number of S-shaped connecting ribs 4. The two ends are connected through the fan-shaped ring to form a closed loop, so that each supporting module is independent from each other and can work in coordination. The fourth module, the fifth module and the sixth module adopt a B support module structure mode and are mainly in contact with calcified tissues or severe narrow parts. The in-service device comprises a proximal end and a distal end. The three groups of wing-shaped knots 3 and the valve sewing section 2 are uniformly distributed on the circumference of the bracket main body and connected with the bracket main body in a laser welding mode, the valve sewing section is made of cobalt chromium alloy with the diameter of 8 multiplied by 0.9 multiplied by 0.2mm or 316L, and 8 through holes with the diameter of 0.2-0.4mm are formed in the middle for sewing the valve 8. Before expanding, the wing-shaped knot 3 and the main body of the bracket are on the same plane, and are conveniently compressed into the conveying device. The bent section 5 is provided with a groove 7 with the thickness of 1 multiplied by 0.3 multiplied by 0.2mm, and when the support is implanted, the wing-shaped knot 3 is outwards turned by 50-60 degrees at the groove 7 and is in an umbrella-shaped radial shape.
The second embodiment:
as shown in fig. 7, a second embodiment of the modular design method of the present invention is shown. Can be obtained by adopting a modular design method
Figure BDA0002654879440000063
A valvular stent in which the a-shaped support modules are of mirror image open-loop structural design, comprisingThe two ends of the six V-shaped unit waves are connected through a fan-shaped ring, and the middle of the six V-shaped unit waves is connected through an S-shaped connector; the B-type supporting module is designed for a mirror closed loop structure, comprises six V-shaped unit waves which are symmetrical up and down, two ends of the V-shaped unit waves are connected through a fan-shaped ring, and wave crests of the V-shaped unit waves are connected through three S-shaped connectors. The type has complementary functions compared with the first embodiment, and is suitable for the condition that the valve support part at the lower end of the valve ring needs great support strength, and the condition that the support strength at the far end is high. So the design scheme of scheme two is adopted. That is, the first module 11, the second module 12, and the third module 13 all adopt a B-support module structure mode, and the fourth module 14, the fifth module 15, and the sixth module 16 all adopt an a-support module structure mode.
The second embodiment is of modular design
Figure BDA0002654879440000071
The valve stent comprises a valve stent main body consisting of six support modules, a V-shaped unit wave 1, S-shaped connecting ribs 4 wing-shaped knots 3, a connecting section 6, a bending section 5, a groove 7 and the like. Each support module consists of a V-shaped unit wave 1 and a different number of S-shaped connecting ribs 4. The two ends are connected through the fan-shaped ring to form a closed loop, so that each supporting module is independent from each other and can work in coordination. The first module 11, the second module 12 and the third module 13 adopt a B support module structure mode and are mainly in contact with calcified tissues or severe narrow parts. The in-service device comprises a proximal end and a distal end. The three groups of wing-shaped knots 3 and the valve sewing section 2 are uniformly distributed on the circumference of the bracket main body and connected with the bracket main body in a laser welding mode, the valve sewing section is made of cobalt chromium alloy with the diameter of 8 multiplied by 0.9 multiplied by 0.2mm or 316L, and 8 through holes with the diameter of 0.2-0.4mm are formed in the middle for sewing the valve 8. Before expanding, the wing-shaped knot 3 and the main body of the bracket are on the same plane, and are conveniently compressed into the conveying device. The bent section 5 is provided with a groove 7 with the thickness of 1 multiplied by 0.3 multiplied by 0.2mm, and when the support is implanted, the wing-shaped knot 3 is outwards turned by 50-60 degrees at the groove 7 and is in an umbrella-shaped radial shape.
The third embodiment is as follows:
as shown in FIG. 8, the third embodiment of the modular design method of the present invention. Can be obtained by adopting a modular design method
Figure BDA0002654879440000072
The A-type support module is designed in a mirror image open-loop structure and comprises six V-type unit waves which are symmetrical up and down, two ends of the A-type support module are connected through a fan-shaped ring, and the middle of the A-type support module is connected through an S-shaped connector; the B-type supporting module is designed for a mirror closed loop structure, comprises six V-shaped unit waves which are symmetrical up and down, two ends of the V-shaped unit waves are connected through a fan-shaped ring, and wave crests of the V-shaped unit waves are connected through three S-shaped connectors. This type is directed to aortic valves where one leaflet is heavily calcified and the other two leaflets are lightly calcified. And the proximal end and the distal end have calcification or stenosis at different sizes, so a mixed and overlapped cross mode design scheme of the third scheme is adopted. That is, the second module, the third module, the fourth module and the fifth module all adopt the structure mode of the A support module, and the first module 11 and the fifth module 15 adopt the structure mode of the B support module.
The embodiment is of a triple modular design
Figure BDA0002654879440000073
The valve stent comprises a valve stent main body consisting of six support modules, a V-shaped unit wave 1, S-shaped connecting ribs 4 wing-shaped knots 3, a connecting section 6, a bending section 5, a groove 7 and the like. Each support module consists of a V-shaped unit wave 1 and a different number of S-shaped connecting ribs 4. The two ends are connected through the fan-shaped ring to form a closed loop, so that each supporting module is independent from each other and can work in coordination. The first module 11 and the fifth module 15 adopt a B support module structure mode, and are mainly contacted with calcified tissues or severe parts of stenosis. The in-service device comprises a proximal end and a distal end. The three groups of wing-shaped knots 3 and the valve sewing section 2 are uniformly distributed on the circumference of the bracket main body and connected with the bracket main body in a laser welding mode, the valve sewing section is made of cobalt chromium alloy with the diameter of 8 multiplied by 0.9 multiplied by 0.2mm or 316L, and 8 through holes with the diameter of 0.2-0.4mm are formed in the middle for sewing the valve 8. Before expanding, the wing-shaped knot 3 and the main body of the bracket are on the same plane, and are conveniently compressed into the conveying device. A concave with the thickness of 1 multiplied by 0.3 multiplied by 0.2mm is arranged at the position 5 of the bending sectionThe groove 7 is in an umbrella-shaped radial shape when the wing-shaped knot 3 is turned outwards by 50-60 degrees at the groove 7 after the stent is implanted.
It should be understood that although the present description has been described in terms of various embodiments, not every embodiment includes only a single embodiment, and such description is for clarity purposes only, and those skilled in the art will recognize that the embodiments described herein may be combined as suitable to form other embodiments, as will be appreciated by those skilled in the art.
The above-listed detailed description is only a specific description of a possible embodiment of the present invention, and they are not intended to limit the scope of the present invention, and equivalent embodiments or modifications made without departing from the technical spirit of the present invention should be included in the scope of the present invention.

Claims (10)

1. An anti-migration aortic valve stent is characterized by comprising a valve stent main body, a valve (8), a valve sewing section (2) and wing-shaped knots (3);
the valve support main body comprises a far-end and a near-end which are connected, the far-end and the near-end respectively comprise at least three supporting modules, and the supporting modules are connected through a valve sewing section (2); the valve (8) is arranged in the valve support main body and is connected with the valve sewing section (2);
each supporting module comprises two rows of unit wave bands which are arranged up and down, each row of unit wave bands comprise a plurality of V-shaped unit waves (1), the wave crests of the V-shaped unit waves (1) of the two rows of unit wave bands are opposite, the peak valleys of the V-shaped unit waves (1) at the tail ends of the two sides of the upper row of unit wave bands and the lower row of unit wave bands are connected, and partial or all opposite wave crests of the upper row of unit wave bands and the lower row of unit wave bands are connected to form different types of supporting modules;
be equipped with wing knot (3) in the V type unit ripples (1) of telecentric end lower row respectively, wing knot (3) are the chevron shape and include bendable section (5) at top and linkage segment (6) at bottom both ends, and bendable section (5) at top stretch to the crest of V type unit ripples (1), and linkage segment (6) at bottom both ends are connected with the trough of V type unit ripples (1), both sides between bending section (5) and linkage segment (6) are equipped with fore-and-aft recess (7), wing knot (3) can be bent and outside upset alpha degree in recess (7) department, and a plurality of outside wing knots (3) of buckling are radially in the circumference of valve support main part and are used for contacting with valve ring (9).
2. The anti-migration aortic valve stent as set forth in claim 1, wherein a is 50-60 degrees.
3. The migration resistant aortic valve stent of claim 1 wherein the distal end and proximal end each comprise three support modules.
4. The anti-migration aortic valve stent as claimed in claim 3, wherein each row of unit wave bands of each support module comprises 3V-shaped unit waves (1), and the number of the winged knots (3) is nine.
5. The anti-migration aortic valve stent as claimed in claim 4, wherein the opposite peaks in the upper and lower rows of unit wave bands of the supporting module are connected to form an A-type supporting module; all opposite wave crests in the upper and lower rows of unit wave bands of the supporting module are connected to form a B-type supporting module; the a-type support module and the B-type support module can be combined to form different valve stent bodies.
6. The migration resistant aortic valve stent of claim 5 wherein the combination of the A-type support module and the B-type support module is
Figure FDA0002654879430000011
Or
Figure FDA0002654879430000012
Figure FDA0002654879430000013
The three modules representing the far end adopt A-type supporting modules, and the three modules representing the near end adopt B-type supporting modules;
Figure FDA0002654879430000014
the three modules representing the far-end adopt a B-type support module, an A-type support module and an A-type support module, and the near-end adopts an A-type support module, an A-type support module and a B-type support module;
Figure FDA0002654879430000015
the three modules representing the far-end adopt an A-type support module, an A-type support module and a B-type support module, and the near-end adopts a B-type support module, an A-type support module and an A-type support module.
7. The migration-resistant aortic valve support frame as claimed in claim 3, wherein the peaks and valleys of the two endmost V-shaped unit waves (1) in the two upper and lower rows of unit wave bands of the A-shaped support module are connected by a fan-shaped ring, and the peaks of the middle V-shaped unit waves (1) are connected by an S-shaped connecting rib (4).
8. The anti-migration aortic valve stent as claimed in claim 3, wherein the peaks and valleys of the two endmost V-shaped unit waves (1) in the two rows of unit wave bands of the B-shaped support module are connected by a fan-shaped ring, and the peaks of the three V-shaped unit waves (1) are connected by the S-shaped connecting rib (4).
9. The anti-migration aortic valve stent as claimed in claim 1, wherein the valve (8) is made of pure polymer material, swim bladder, porcine pericardium, bovine pericardium or high polymer material.
10. The migration resistant aortic valve support of claim 1 wherein the winged nodules (3) are made of nitinol.
CN202010883633.7A 2020-08-28 2020-08-28 Anti-migration aortic valve stent Active CN112089508B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010883633.7A CN112089508B (en) 2020-08-28 2020-08-28 Anti-migration aortic valve stent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202010883633.7A CN112089508B (en) 2020-08-28 2020-08-28 Anti-migration aortic valve stent

Publications (2)

Publication Number Publication Date
CN112089508A true CN112089508A (en) 2020-12-18
CN112089508B CN112089508B (en) 2022-11-18

Family

ID=73758163

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202010883633.7A Active CN112089508B (en) 2020-08-28 2020-08-28 Anti-migration aortic valve stent

Country Status (1)

Country Link
CN (1) CN112089508B (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080208327A1 (en) * 2007-02-27 2008-08-28 Rowe Stanton J Method and apparatus for replacing a prosthetic valve
US20110060401A1 (en) * 2007-02-16 2011-03-10 Universität Zürich Tubular Supporting Prosthesis Capable of Growing
US20160278922A1 (en) * 2015-03-24 2016-09-29 St. Jude Medical, Cardiology Division, Inc. Mitral heart valve replacement
CN107252363A (en) * 2015-03-26 2017-10-17 杭州启明医疗器械有限公司 Reduce the valve bracket of reduction length and the valve replacement device with the valve bracket
US20180071089A1 (en) * 2016-09-15 2018-03-15 St. Jude Medical, Cardiology Division, Inc. Prosthetic heart valve with paravalvular leak mitigation features
CN209790095U (en) * 2018-09-03 2019-12-17 高洋 Valve support that cardiac surgery is suitable for

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110060401A1 (en) * 2007-02-16 2011-03-10 Universität Zürich Tubular Supporting Prosthesis Capable of Growing
US20080208327A1 (en) * 2007-02-27 2008-08-28 Rowe Stanton J Method and apparatus for replacing a prosthetic valve
US20160278922A1 (en) * 2015-03-24 2016-09-29 St. Jude Medical, Cardiology Division, Inc. Mitral heart valve replacement
CN107252363A (en) * 2015-03-26 2017-10-17 杭州启明医疗器械有限公司 Reduce the valve bracket of reduction length and the valve replacement device with the valve bracket
US20180071089A1 (en) * 2016-09-15 2018-03-15 St. Jude Medical, Cardiology Division, Inc. Prosthetic heart valve with paravalvular leak mitigation features
CN209790095U (en) * 2018-09-03 2019-12-17 高洋 Valve support that cardiac surgery is suitable for

Also Published As

Publication number Publication date
CN112089508B (en) 2022-11-18

Similar Documents

Publication Publication Date Title
JP5995110B2 (en) Intraventricular low profile prosthetic mitral valve
EP1643938B1 (en) Prosthetic valves for medical application
CN110167488B (en) Prosthetic heart valve with leaflet inflow under frame
CN107184292B (en) Articulating commissure valve stents and methods
JP5250046B2 (en) Percutaneous heart valve, system, and method
EP2257242B1 (en) Infundibular reducer devices
JP4383707B2 (en) Spherical valve and stent for treating vascular reflux
US6767362B2 (en) Minimally-invasive heart valves and methods of use
EP1229865B1 (en) Endovascular treatment for chronic venous insufficiency
KR101617052B1 (en) Stented heart valve devices
US11877927B2 (en) Expandable frame for improved hemodynamic performance of transcatheter replacement heart valve
CN111035473A (en) Artificial heart valve prosthesis and stent thereof
CN209377809U (en) A kind of heart valve prosthesis prosthese and its bracket
CN115252221B (en) Artificial heart valve
CN111772879A (en) Artificial heart valve
CN111772878A (en) Heart valve prosthesis
CN113331999A (en) Valve prosthesis
CN212395132U (en) Heart valve prosthesis
CN117462304A (en) Prosthetic heart valve and transcatheter heart valve replacement system
CN112089508B (en) Anti-migration aortic valve stent
US11399933B2 (en) Cardiac valve prosthesis and stent thereof
CN113545890B (en) Novel transcatheter mitral valve
CN215273616U (en) Valve prosthesis
CN212395131U (en) Artificial heart valve
CN212395136U (en) Self-expanding atrioventricular valve prosthesis device

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant