CN112067830A - Coagulation reagent management methods and systems - Google Patents

Abstract

The invention relates to the technical field of medical instruments, in particular to a blood coagulation reagent management method and system. The management system comprises a first reagent container, wherein the first reagent container is provided with at least two first reagent cavities which are mutually independent and are used for containing established reagents required by the blood coagulation test items in a one-to-one correspondence mode, so that the first reagent container can independently finish the blood coagulation test items of preset times. Therefore, the reagent can be managed through each blood coagulation test item in the reagent management and detection processes, the traditional condition that one reagent is not enough but the other reagent is not enough is avoided, the detection efficiency is improved, and the reagent cost is saved. Simultaneously, the blood coagulation test items of preset times are independently completed through the first reagent container, the reagent required by the corresponding blood coagulation test items is conveniently loaded and replaced at one time, and the efficiency of reagent loading and replacement of a user is effectively improved.

Description

Coagulation reagent management methods and systems

Technical Field

The invention relates to the technical field of medical instruments, in particular to a blood coagulation reagent management method and system.

Background

In current fully automated coagulation analyzers, coagulation reagents typically use a single glass or plastic vial as a carrier to support the test. Different types of coagulation reagents need to be packaged by adopting glass bottles or plastic bottles with different specifications. The common glass bottle or plastic bottle has large tolerance variation of the bottle bottom due to the limitation of the processing technology, and the influence of the diameter of a large-capacity reagent bottle causes that the residual amount of the reagent is difficult to control. In fully automated coagulation assays, a significant increase in reagent residue is typically incurred, leading to increased costs for testing by the user.

The existing blood coagulation reagent adopts an independent packaging form of a mixed reagent and a trigger reagent, and the situation that a user needs to replace the reagent due to the fact that the residual quantity of the reagent is not easy to control due to lack of the mixed reagent or the trigger reagent often occurs in the testing process. The user is difficult to judge how many tests can be carried out to the reagent in the current instrument in support of a certain test item before testing, whether need in time add reagent, therefore bring a lot of inconveniences for reagent management. In addition, coagulation reagents are currently stored in glass or plastic bottles, with a common nominal volume loading. In the actual test process, the instrument judges the height of the residual reagent through real-time liquid level detection, and the diameter information of the reagent bottle is combined to give the residual test quantity which can be supported by the current reagent. Due to the large amount of reagent residues, it is difficult for the user to perform the nominal number of tests in the nominal volume loading, resulting in increased cost per test for the user. Meanwhile, the real-time liquid level detection technology provides more complex requirements for the detection speed of the full-automatic coagulation analyzer and the reliability of the whole instrument.

Disclosure of Invention

In view of the above, there is a need to provide a coagulation reagent management method and system for solving the problem of difficulty in controlling reagent content of conventional coagulation reagent packages.

A coagulation reagent management system comprising:

the first reagent container is used for containing a set reagent required by a certain preset blood coagulation test item in the blood coagulation analysis instrument, the first reagent container is provided with at least two first reagent containing cavities, and the at least two first reagent containing cavities are arranged independently to respectively contain the set reagent required by the blood coagulation test item in a one-to-one correspondence mode, so that the first reagent container can independently complete the preset blood coagulation test item.

In one embodiment, the coagulation reagent management system further comprises a second reagent container having a second reagent chamber for containing additional reagents required for the custom coagulation test item, the second reagent container being configured to be used on the computer simultaneously with the first reagent container to complete the custom coagulation test item.

In one embodiment, the coagulation reagent management system further comprises:

the reagent tray is provided with a plurality of mounting positions, and each mounting position is used for mounting a first reagent container or a second reagent container; and

and the controller is used for controlling the display device to display the installation positions of the first reagent container and the second reagent container on the reagent tray, and controlling the display device to display detailed information of the reagents contained in the first reagent container and the second reagent container.

In one embodiment, the controller comprises a control interface for a user to select a designated first reagent container and/or second reagent container;

alternatively, the controller can select the first reagent container and/or the second reagent container according to a preset rule.

In one embodiment, the coagulation reagent management system further comprises a scanner connected to the controller, the scanner configured to acquire mounting position information of the first reagent container and the second reagent container, and to acquire detailed information of the reagents contained in the first reagent container and the second reagent container, and to transmit the acquired mounting position information and the detailed information of the reagents to the controller.

In one embodiment, the coagulation reagent management system further comprises a transfer mechanism disposed at one side of the reagent tray, wherein the transfer mechanism is used for mounting the first reagent container and/or the second reagent container to the corresponding mounting position or removing the designated first reagent container and/or second reagent container from the mounting position.

In one embodiment, the coagulation reagent management system further includes a first label disposed in the first reagent container, wherein the first label at least includes name information of a reagent contained in the first reagent container, and test item information and total test number information supported by the reagent contained in the first reagent container.

In one embodiment, the base of the first reagent reservoir comprises a tapered portion having an internal diameter which decreases in area in the direction of gravity.

In one embodiment, the bottom of the first reagent holding chamber further comprises a cylindrical portion and a spherical bottom surface, and the conical portion, the cylindrical portion and the spherical bottom surface are arranged in sequence along the gravity direction and are smoothly connected.

In one embodiment, the first reagent container further comprises a reagent bottle base and a reagent bottle cap, the reagent bottle cap is arranged on the reagent bottle base and located on one side of the opening of the first reagent containing cavity, the reagent bottle cap is provided with a liquid suction port corresponding to the opening of the first reagent containing cavity, a puncture film is arranged at the liquid suction port, and a layer of easily-torn film is thermally sealed above the puncture film.

In one embodiment, the puncture membrane is made of soft rubber, and a cross-shaped or m-shaped or triangular opening is formed in the center of the puncture membrane.

A method of coagulation reagent management comprising the steps of:

dispensing reagents according to a coagulation test item set by a coagulation analyzer;

the method comprises the steps that a set reagent required by a blood coagulation test item is contained in a first reagent container, wherein the first reagent container is provided with at least two first reagent cavities which are mutually independent and used for respectively containing the set reagent required by the blood coagulation test item in a one-to-one correspondence manner;

the clotting test items are completed using the reagents in the first reagent container.

In one embodiment, the coagulation reagent management method further comprises the steps of:

acquiring the total test times supported by a given reagent contained in a first reagent container;

recording the number of test completion times that a given reagent contained in a first reagent container has supported;

and obtaining the residual test times according to the total test times and the test completion times.

In one embodiment, the coagulation reagent management method further comprises the steps of:

and acquiring the residual test frequency, and replacing the first reagent container when the acquired residual test frequency is 0.

In one embodiment, the coagulation reagent management method further comprises the steps of:

transporting the first reagent container with the remaining test number of 0 from the mounting site thereof to a disposal hole or a buffer area; and

another first reagent container containing a predetermined reagent is automatically or manually placed in the mounting position.

In one embodiment, the coagulation reagent management method further comprises the steps of:

when a user-defined blood coagulation test item is required to be performed, accommodating an additional reagent required by the user-defined blood coagulation test item into a second reagent container, wherein the second reagent container is provided with a second reagent cavity for accommodating the additional reagent;

completing a custom coagulation test project by using reagents in the first reagent container and the second reagent container;

or a custom coagulation test program is completed using reagents in a single or multiple second reagent containers.

The beneficial effects of the invention include:

the first reagent container is capable of independently performing a predetermined number of coagulation test items by using a first reagent container including at least two reagent containers for containing predetermined reagents required for the coagulation test items. Therefore, the reagent can be managed through each blood coagulation test item in the reagent management and detection processes, the traditional condition that one reagent is not enough but the other reagent is not enough is avoided, the detection efficiency is improved, and the reagent cost is saved. Simultaneously, the blood coagulation test items of preset times are independently completed through the first reagent container, the reagent required by the corresponding blood coagulation test items is conveniently loaded and replaced at one time, and the efficiency of reagent loading and replacement of a user is effectively improved.

Drawings

FIG. 1 is a schematic diagram of a coagulation reagent management system according to an embodiment of the present invention;

FIG. 2 is an exploded view of the first reagent container of the configuration shown in FIG. 1;

FIG. 3 is a schematic sectional view of the first reagent container and reagent disk mounting structure of the FIG. 1 structure;

FIG. 4 is a schematic diagram of the construction of a first reagent container of the construction shown in FIG. 1;

FIG. 5 is a schematic diagram of a coagulation reagent management system according to another embodiment of the present invention;

fig. 6 is a flowchart of a method for managing a coagulation reagent according to an embodiment of the present invention.

Description of reference numerals:

100-a first reagent container;

110-a first reagent reservoir;

111-a tapered portion; 112-a cylindrical portion; 113-spherical bottom surface;

120-reagent bottle base; 121-a non-slip part;

130-reagent bottle cap; 131-a liquid suction port; 132-a puncturing membrane; 133-easy-to-tear film;

140-a push rod groove;

150-grabbing holes by a mechanical arm;

200-a second reagent container;

210-a second reagent reservoir;

300-reagent tray;

310-an installation site;

400-liquid suction needle.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the method and system for managing a coagulation reagent of the present invention are described in further detail below by way of examples with reference to the accompanying drawings. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. In contrast, when an element is referred to as being "directly on" another element, there are no intervening elements present. The terms "vertical," "horizontal," "left," "right," and the like as used herein are for illustrative purposes only.

Referring to fig. 1 and 2, a blood coagulation reagent management system according to an embodiment of the present invention includes: the first reagent container 100 is configured to contain a predetermined reagent required by a predetermined coagulation test item in the coagulation analyzer, the first reagent container 100 has at least two first reagent containers 110, and the at least two first reagent containers 110 are independently disposed to respectively contain the predetermined reagent required by the coagulation test item in a one-to-one correspondence manner, so that the first reagent container 100 can independently complete the coagulation test items for a predetermined number of times.

Specifically, it is assumed that the intended reagents required for a certain coagulation test item are the mixed reagent R1 and the trigger reagent R2. The first reagent container 100 has two first reagent containers 110, and the two first reagent containers 110 respectively contain the mixed reagent R1 and the trigger reagent R2. When the mixed reagent R1 and the trigger reagent R2 are filled, the added mixed reagent R1 and the trigger reagent R2 belong to the same batch and have consistent shelf life. The mixed reagent R1 and the trigger reagent R2 which are added simultaneously are added according to the dosage of the reagents required by the blood coagulation test item. For example, assuming that 50uL of mixed reagent R1 and 100uL of trigger reagent R2 are required for each test, the ratio of mixed reagent R1 to trigger reagent R2 is also determined according to R1: and R2 is filled in a total volume of 1: 2. Thus, the first reagent container 100 can support the test of the coagulation test item for a preset number of times, and ensure that the residual amounts of the two reagents are basically consistent after each test, so that the condition that one reagent is still and the other reagent is insufficient can not occur. In other embodiments, if there are multiple reagents required for a coagulation test item, the first reagent container 100 may also be designed to have multiple first reagent cavities 110 to respectively contain the multiple reagents required in proportion. Alternatively, two or more first reagent containers 100 may be combined to test the coagulation test item. Each first reagent container 100 may have two first reagent containers 110, and the reagents contained in the first reagent containers 110 of the first reagent containers 100 are filled according to the reagent dosage ratio.

In addition, in the coagulation test item, only the trigger reagent R2 is required for a part of items, and the mixed reagent R1 is not required. For these test items, such as PT items, at least two of the first reagent containers 110 in the first reagent container 100 corresponding to the item may contain the required trigger reagent R2 in only one of the first reagent containers 110, while the other first reagent containers 110 are not filled with reagent and the other first reagent containers 110 are empty. Alternatively, all of the first reagent chambers 110 may be filled with the desired trigger reagent R2. Illustratively, as shown in fig. 2, the number of the first reagent chambers 110 is two, wherein one first reagent chamber 110 contains a first reagent required by any one coagulation test item, and the other first reagent chamber 110 contains a second reagent corresponding to the first reagent, or contains the first reagent, or is empty. Thus, two or one reagent can be contained in the first reagent container 100 according to the supported coagulation test item, thereby smoothly performing the corresponding coagulation test item without the need for a user to add a reagent by himself/herself.

When each first reagent container 100 is filled, the total number of blood coagulation test items supported by the respective first reagent container 100, and information on the type, name, and reagent lot of the filled reagent, expiration date, and the like can be directly given. In one embodiment, the coagulation reagent management system further comprises a first label (not shown) disposed on the first reagent container 100. The first label includes at least name information of the reagent contained in the first reagent container 100, and test item information and total number of supported tests information supported by the reagent contained in the first reagent container 100. The first tag may be a bar code, a two-dimensional code, or an RFID reader (radio frequency identification reader). When each first reagent container 100 is shipped, the information is written in the first label and fixed to the corresponding first reagent container 100. Thereby obtaining detailed information of the reagent contained in each of the first reagent containers 100 by obtaining the information on the first label. In a specific use, the information on the first label is read to obtain the coagulation test items and the total number of tests that can be supported by the first reagent container 100. And the number of tests supported by the first reagent vessel 100 is recorded after each test is completed, and then the remaining number of tests can be accurately obtained according to the total number of tests and the number of supported tests. Therefore, the counting of the residual test number of the reagent by using the liquid level detection technology and other technologies in the prior art is not needed, the problem of inaccurate result caused by mechanical error is solved, and the test speed of the instrument and the reliability of the whole instrument are improved.

It is noted that the information contained in the first label may include, in addition to the information of the reagent name, the supported test items, and the total number of tests supported, the reagent production date, expiration date (e.g., seal expiration date or seal expiration date), the ID code and/or calibration information of the reagent container, and the like.

In the coagulation reagent management system of the present embodiment, the first reagent container 100 including at least two reagent containers is used to contain a predetermined reagent required for a coagulation test item, and the first reagent container 100 is capable of independently performing a predetermined number of the coagulation test item. Therefore, the reagent can be managed through each blood coagulation test item in the reagent management and detection processes, the traditional condition that one reagent is not enough but the other reagent is not enough is avoided, the detection efficiency is improved, and the reagent cost is saved. Simultaneously, the blood coagulation test items of preset times are independently completed through the first reagent container 100, the reagent required by the corresponding blood coagulation test items is conveniently loaded and replaced at one time, and the efficiency of reagent loading and replacement of a user is effectively improved.

Referring to fig. 4, as an implementable manner, the bottom of the first reagent vessel 110 includes a tapered portion 111, and the inner diameter area of the tapered portion 111 is gradually reduced in the gravity direction. Through the design of the first reagent containing cavity 110 comprising the bottom of the conical part 111, the reagent at the bottom can be conveniently sucked, the dead volume at the bottom is reduced, and the residual quantity of the reagent is reduced, so that the reagent is effectively saved, and the reagent cost is reduced. Illustratively, as shown in fig. 4, the bottom of the first reagent holding chamber 110 includes a tapered portion 111, a cylindrical portion 112 and a spherical bottom surface 113 which are arranged in sequence along the gravity direction, and the tapered portion 111, the cylindrical portion 112 and the spherical bottom surface 113 are smoothly connected. The reagent is easily accumulated at the spherical bottom surface 113 of the bottom by the tapered portion 111, and the amount of the reagent which can be accumulated at the bottom of the first reagent holding chamber 110 can be increased by the cylindrical portion 112, thereby facilitating the reagent aspiration by the pipette needle 400.

Referring to fig. 2, in one embodiment, the first reagent container 100 further includes a reagent bottle base 120 and a reagent bottle cap 130, and the reagent bottle cap 130 is disposed on the reagent bottle base 120 at a side where the opening of the first reagent receiving chamber 110 is located. The reagent bottle cap 130 is provided with a liquid suction port 131 corresponding to the opening of the first reagent container 110, a puncture film 132 is arranged at the liquid suction port 131, and a layer of easy-to-tear film 133 is heat-sealed above the puncture film 132.

It will be appreciated that the first reagent vessel 110 may be formed directly on the reagent bottle base 120. Referring to fig. 2, in one embodiment, the reagent bottle base 120 defines at least two chambers, and each chamber defines a first reagent chamber 110 for containing a reagent. In actual production, at least two chambers can be formed on one reagent bottle base 120 by opening the mold, so as to form a unitary first reagent container 100 with at least two first reagent vessels 110. The reagent bottle base 120 is provided with a reagent bottle cap 130, the reagent bottle cap 130 is provided with a liquid suction port 131, and the liquid suction port 131 is provided with a puncture film 132 and an easy-to-tear film 133. Wherein, the puncture membrane 132 is a structure integrating the functions of sealing and preventing volatilization and puncturing. As shown in fig. 4, the puncture membrane 132 may be made of a soft rubber material, and an opening having a cross shape, a meter shape, or a triangle shape is formed in the center of the puncture membrane 132 so that the pipette needle 400 can be inserted smoothly. Or, the puncture membrane 132 is a full-sealing membrane made of soft plastic material, and no opening is formed in the puncture membrane 132, so that when the pipette needle 400 needs to pipette liquid from the first reagent container 110, the puncture membrane 132 can be directly punctured. As shown in fig. 2, the puncture membrane 132 and the reagent bottle cap 130 may be separate structures independent of each other. In other embodiments, the reagent bottle cap 130 and the puncture membrane 132 may be designed as an integral soft gel puncture cover structure. The tear film 133 may be a single film provided for each of the liquid suction ports 131. The tear film 133 may be a long tear film, and may simultaneously close the plurality of liquid suction ports 131. By providing a tear film 133, a secure seal of the reagent can be achieved after the first reagent container 100 has been filled with reagent, and removal of the tear film 133 to activate the reagent during use can be facilitated. Through setting up puncture membrane 132, can greatly reduce the volume of volatilizing of the reagent after starting, promote reagent at quick-witted stability, promote the testing performance.

In other embodiments, the first reagent container 110 may be formed of a single bottle body and integrated into one reagent bottle base 120 to form the first reagent container 100 with at least two first reagent containers 110. Illustratively, the reagent bottle base 120 includes at least two fixing grooves, each of which has a reagent bottle fixed therein, and an inner wall of the reagent bottle forms a first reagent holding chamber 110 for holding a reagent. A puncture film 132 can be arranged at the bottleneck of each reagent bottle, and an easy-tear film 133 can be thermally sealed above the puncture film 132. Through easy tear film 133 and puncture membrane 132, can realize the reliable sealed of not starting reagent, reduce the reagent volume of volatilizing after starting simultaneously, promote reagent stability on the machine, promote the testing performance.

Referring to fig. 2, in one embodiment, the reagent bottle base 120 is provided with a slip prevention part 121. The anti-slip part 121 is an anti-slip cone or an anti-slip taper hole or an anti-slip stripe provided on the sidewall of the reagent bottle base 120. Grasping of the first reagent container 100 by the user may be facilitated by providing the anti-slip portion 121.

Referring to fig. 1, as an implementable manner, the coagulation reagent management system further includes a second reagent container 200, the second reagent container 200 having a second reagent reservoir 210. The second reagent container 200 is used for accommodating additional reagents required for the custom coagulation test item, and the second reagent container 200 is used on the computer simultaneously with the first reagent container 100 to complete the custom coagulation test item. By adding the second reagent container 200, the reagent in the second reagent container 200 can be combined with the reagent in the first reagent container 100 to complete the user-defined coagulation test item, so that the requirements of customers for using various third-party reagents can be met, and open reagent management and use are realized.

Specifically, the first reagent container 100 contains a predetermined reagent required for a test item associated with the instrument, and the second reagent container 200 contains a third-party reagent, i.e., an additional reagent required for a custom coagulation test item required by a user. The second reagent container 200 may be provided in plural, and each of the plural is used for placing a plurality of third-party reagents, so that the plural second reagent containers 200 and the first reagent container 100 can jointly complete a coagulation test item customized by a user. The second reagent container 200 may be provided with a second label, and the second label may include information on a kind of reagent, a name, a date of reagent production, a expiration date (e.g., a seal expiration date or an unseal expiration date), an ID code of the reagent container, and the like.

In other embodiments, the reagents in the second reagent container 200 can be used individually according to actual requirements to complete the corresponding coagulation test items. E.g., PT item, which only requires the use of the trigger reagent R2. The second reagent container 200 may now be used to hold a reagent amount of R2 to support the completion of a preset number of PT entries.

Referring to fig. 1, as one implementable manner, the coagulation reagent management system further includes a reagent tray 300 and a controller (not shown). The reagent disk 300 is provided with a plurality of mounting locations 310, each mounting location 310 being for mounting a first reagent container 100 or a second reagent container 200, respectively. The controller is used to control a display device (not shown) to display the mounting positions of the first and second reagent containers 100 and 200 on the reagent disk 300, and to control the display device to display detailed information of the reagents contained in the first and second reagent containers 100 and 200. It is understood that the reagent disk 300 may be a circular reagent disk, as shown in FIG. 1, with a plurality of mounting locations 310 distributed circumferentially around the reagent disk 300. As shown in fig. 5, the reagent disk 300 may be a rectangular reagent disk, and a plurality of mounting positions 310 may be distributed along the longitudinal direction of the reagent disk 300. The reagent bottle base 120 of the first reagent container 100 may be provided with a fixing structure, such as an elastic snap, for fixing the first reagent container 100 to the reagent disk 300. Accordingly, the reagent disk 300 is provided with a structure that mates with a fixed structure on the reagent bottle base 120, such as two detents that mate with a resilient snap fit.

Each mounting site 310 of the reagent disk 300 may be provided with a position tag containing information such as the ID of the mounting site 310. The display means may have display areas corresponding one-to-one to the shape of the reagent disk 300 and the respective mounting positions 310. It is understood that one mounting site 310 can only correspondingly mount one first reagent vessel 100 or one second reagent vessel 200. The reagent disk 300 may be mounted with only the first reagent container 100 or the second reagent container 200. The reagent disk 300 may be provided with the first reagent container 100 and the second reagent container 200 at the same time. Assuming that a plurality of first reagent containers 100 are mounted on the reagent disk 300, when a first reagent container 100 is mounted in a certain mounting location 310, the controller may acquire information on a first label on the first reagent container 100 and information on a position label of the mounting location 310 and bind the two together to be displayed at a corresponding position of a display area of the display device.

The manner in which the controller acquires the corresponding information may be various. In one embodiment, the coagulation reagent management system further comprises a scanner (not shown) coupled to the controller. The scanner is configured to acquire mounting position information of the first and second reagent containers 100 and 200 and detailed information of the reagents contained in the first and second reagent containers 100 and 200, and transmit the acquired mounting position information and the detailed information of the reagents to the controller. The position label of the installation position 310 to be installed and the first label or the second label correspondingly installed on the installation position 310 are scanned by the scanner, and the information obtained by scanning is sent to the controller, so that the controller can conveniently obtain corresponding information.

In one embodiment, the controller includes a control interface (not shown) for a user to select a designated first reagent container 100 and/or second reagent container 200. It is understood that the control interface may be a touch interface or a key interface, and the control interface is disposed on the display device corresponding to a display area of the display device. Through the control interface, the user can select the first reagent container 100 and/or the second reagent container 200 designated on the reagent disk 300 in a touch or press manner as necessary to perform the coagulation test item.

Alternatively, the controller can select the first reagent container 100 and/or the second reagent container 200 according to a preset rule. The preset rule refers to a default selection rule written in the controller program, for example, a rule for preferentially selecting a reagent container with the reagent production date at the top, or a rule for preferentially using a reagent container with a lid opened. Specifically, when a plurality of first reagent containers 100 are mounted on the reagent disk 300, the controller has obtained detailed information of the mounting positions of the respective first reagent containers 100 and the reagents contained therein. That is, the controller knows the location of each first reagent container 100, as well as the coagulation test items it supports and the date of manufacture of the reagents therein. The controller may therefore prefer the use of the reagent by the production date on the basis of a preset rule. Alternatively, after a certain first reagent container 100 is used with its lid opened, the first reagent container 100 that has been opened is preferably selected for use when the same coagulation analysis item is to be tested next time.

In one embodiment, the coagulation reagent management system further includes a transfer mechanism (not shown) disposed on one side of the reagent tray 300. The transfer mechanism is used to mount the first reagent container 100 and/or the second reagent container 200 to the corresponding mounting location 310, or to remove the designated first reagent container 100 and/or second reagent container 200 from the mounting location 310. The transfer mechanism may be an electrically controlled push rod mechanism, and the reagent bottle base 120 of the first reagent container 100 may be provided with a push rod groove 140, and the push rod groove 140 is used for being clamped with one end of an electrically controlled push rod. The reagent bottle base 120 may be mounted to the reagent disk 300 or the reagent bottle base 120 may be detached from the reagent disk 300 by an electrically controlled push rod, thereby achieving automatic loading and unloading of the first reagent container 100. In other embodiments, the transfer mechanism may be a robot, and the reagent bottle base may be provided with a robot gripping hole 150.

Referring to fig. 6, an embodiment of the present invention further provides a blood coagulation reagent management method, including the following steps:

dispensing reagents according to a coagulation test item set by a coagulation analyzer;

a predetermined reagent required for a coagulation test item is contained in one first reagent container 100. As shown in fig. 2, the first reagent container 100 has at least two first reagent chambers 110, and the at least two first reagent chambers 110 are independently arranged to respectively accommodate predetermined reagents required by the blood coagulation test item in a one-to-one correspondence manner;

the coagulation test item is completed using the first reagent vessel 100.

According to the blood coagulation reagent management method, the reagent can be managed through each blood coagulation test item in the reagent management and detection processes, the traditional situation that one reagent is still and the other reagent is insufficient is avoided, the detection efficiency is improved, and the reagent cost is saved. Simultaneously, the blood coagulation test items of preset times are independently completed through the first reagent container 100, the reagent required by the corresponding blood coagulation test items is conveniently loaded and replaced at one time, and the efficiency of reagent loading and replacement of a user is effectively improved.

In one embodiment, the coagulation reagent management method further comprises the steps of: when a custom coagulation test item is required to be performed, an additional reagent required by the custom coagulation test item is contained in a second reagent container 200, the second reagent container 200 is provided with a second reagent cavity 210, and the second reagent cavity 210 is used for containing the additional reagent; completing a custom coagulation test project using reagents in the first reagent container 100 and the second reagent container 200; or to complete custom coagulation test items using reagents in a single or multiple second reagent containers 200.

By adding the second reagent container 200, the reagent in the second reagent container 200 can be combined with the reagent in the first reagent container 100 to complete the user-defined coagulation test item, so that the requirements of customers for using various third-party reagents can be met, and open reagent management and use are realized. In addition, the containers in the second reagent container 200 can be independently used according to actual requirements to complete user-defined coagulation testing projects of users, and the flexibility of reagent management is improved.

In one embodiment, the coagulation reagent management method further comprises the steps of:

acquiring the total number of tests that can be supported by a given reagent contained in the first reagent container 100;

recording the number of completed tests that a given reagent contained in the first reagent container 100 has supported;

and obtaining the residual test times according to the total test times and the test completion times.

In particular, the functions of acquisition, recording and calculation may be implemented by the controller. When each first reagent container 100 is filled, the total number of tests of the coagulation test items supported by the respective first reagent container 100 is written into the first label. The controller scans the first label through the scanner to obtain the total testing times. The controller can also automatically record the number of times the test is completed through the memory. Finally, the controller can calculate the remaining number of tests that can be supported by the reagent in the first reagent container 100 based on the total number of tests and the number of tests completed. Therefore, the counting of the residual test number of the reagent by using the liquid level detection technology and other technologies in the prior art is not needed, the problem of inaccurate result caused by mechanical error is solved, and the test speed of the instrument and the reliability of the whole instrument are improved.

Further, the coagulation reagent management method further comprises the steps of:

the remaining number of tests is acquired, and when the acquired remaining number of tests is 0, the first reagent container 100 is replaced.

It is understood that the first reagent container 100 may be replaced by a mechanical automatic replacement or by a manual replacement. When the machine is automatically replaced, the controller sends a replacement instruction to the transfer mechanism, and the transfer mechanism moves the designated first reagent container 100 (i.e., the first reagent container 100 with the remaining number of tests of 0) out of the corresponding mounting position 310. When the first reagent container 100 is replaced manually, the controller controls the display device to display the position of the first reagent container 100 to be replaced, and the user can manually move the designated first reagent container 100 out of the corresponding mounting position 310. Illustratively, the process of replacing includes: a first reagent container 100 with a remaining test number of 0 is transported from its mounting site 310 to a disposal hole (disposal) or a buffer (available for the user to take away), and another first reagent container 100 containing a predetermined reagent is automatically or manually placed into the mounting site 310.

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims (16)

1. A coagulation reagent management system, comprising:

the first reagent container is used for containing a set reagent required by a certain preset blood coagulation test item in a blood coagulation analysis instrument, and is provided with at least two first reagent cavities which are mutually independently arranged so as to respectively contain the set reagent required by the blood coagulation test item in a one-to-one correspondence manner, so that the first reagent container can independently complete the blood coagulation test item for a preset number of times.

2. The coagulation reagent management system of claim 1, further comprising a second reagent container having a second reagent reservoir, the second reagent container being configured to contain additional reagents required for a custom coagulation test item, the second reagent container being configured for use on the computer concurrently with the first reagent container to complete the custom coagulation test item.

3. The coagulation reagent management system of claim 2, further comprising:

the reagent tray is provided with a plurality of mounting positions, and each mounting position is used for mounting the first reagent container or the second reagent container; and

a controller for controlling a display device to display mounting positions of the first and second reagent containers on the reagent tray, and controlling a display device to display detailed information of reagents contained in the first and second reagent containers.

4. The coagulation reagent management system of claim 3, wherein the controller comprises a control interface for a user to select the first reagent container and/or the second reagent container specified;

alternatively, the controller may be capable of selecting the first reagent container and/or the second reagent container according to a preset rule.

5. The coagulation reagent management system according to claim 3, further comprising a scanner connected to the controller, the scanner configured to acquire mounting position information of the first reagent container and the second reagent container and to acquire detailed information of reagents contained in the first reagent container and the second reagent container and to transmit the acquired mounting position information and the acquired detailed information of the reagents to the controller.

6. The coagulation reagent management system according to claim 3, further comprising a transfer mechanism provided at one side of the reagent tray, the transfer mechanism being configured to mount the first reagent container and/or the second reagent container to the corresponding mounting position or remove the designated first reagent container and/or the designated second reagent container from the mounting position.

7. The coagulation reagent management system according to claim 1, further comprising a first label provided to the first reagent container, the first label including at least name information of a reagent contained in the first reagent container, and test item information and total test number information supported by the reagent contained in the first reagent container.

8. The coagulation reagent management system of claim 1, wherein the bottom of the first reagent reservoir comprises a tapered portion having an inner diameter area that gradually decreases in the direction of gravity.

9. The coagulation reagent management system of claim 8, wherein the bottom of the first reagent holding chamber further comprises a cylindrical portion and a spherical bottom surface, and the conical portion, the cylindrical portion and the spherical bottom surface are arranged in sequence and smoothly connected in the direction of gravity.

10. The blood coagulation reagent management system of claim 1, wherein the first reagent container further comprises a reagent bottle base and a reagent bottle cap, the reagent bottle cap is disposed on the reagent bottle base and located on one side of the opening of the first reagent containing cavity, the reagent bottle cap is provided with a liquid suction port corresponding to the opening of the first reagent containing cavity, a puncture membrane is disposed at the liquid suction port, and a layer of easily-torn membrane is heat-sealed above the puncture membrane.

11. The blood coagulation reagent management system of claim 10, wherein the puncture membrane is made of soft gel, and a cross-shaped, m-shaped or triangular opening is formed in the center of the puncture membrane.

12. A method for managing a coagulation reagent, comprising the steps of:

dispensing reagents according to a coagulation test item set by a coagulation analyzer;

the method comprises the steps that a set reagent required by a blood coagulation test item is contained in a first reagent container, wherein the first reagent container is provided with at least two first reagent cavities which are mutually independent and used for respectively containing the set reagent required by the blood coagulation test item in a one-to-one correspondence manner;

the clotting test items are completed using the reagents in the first reagent container.

13. The coagulation reagent management method according to claim 12, further comprising the steps of:

acquiring the total test times supported by a given reagent contained in a first reagent container;

recording the number of test completion times that a given reagent contained in a first reagent container has supported;

and obtaining the residual test times according to the total test times and the test completion times.

14. The coagulation reagent management method according to claim 13, further comprising the steps of:

and acquiring the residual test frequency, and replacing the first reagent container when the acquired residual test frequency is 0.

15. The coagulation reagent management method according to claim 14, further comprising the steps of:

transporting the first reagent container with the remaining test number of 0 from the mounting site thereof to a disposal hole or a buffer area; and

another first reagent container containing a predetermined reagent is automatically or manually placed in the mounting position.

16. The coagulation reagent management method according to claim 12, further comprising the steps of:

when a user-defined blood coagulation test item is required to be performed, accommodating an additional reagent required by the user-defined blood coagulation test item into a second reagent container, wherein the second reagent container is provided with a second reagent cavity for accommodating the additional reagent;

completing a custom coagulation test project by using reagents in the first reagent container and the second reagent container; or a custom coagulation test program is completed using reagents in a single or multiple second reagent containers.

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