CN112057476A

CN112057476A - Composition and application thereof in sobering-up, hangover-relieving and stomach-protecting

Info

Publication number: CN112057476A
Application number: CN202010967913.6A
Authority: CN
Inventors: 耿福能; 曹嘉; 林庆华
Original assignee: Sichuan Gooddoctor Panxi Pharmaceutical Co ltd
Current assignee: Sichuan Gooddoctor Panxi Pharmaceutical Co ltd
Priority date: 2020-09-15
Filing date: 2020-09-15
Publication date: 2020-12-11
Anticipated expiration: 2040-09-15
Also published as: CN112057476B

Abstract

The invention belongs to the technical field of medicines, and provides a composition and application thereof in sobering up, hangover relieving and stomach protecting. The composition comprises the following effective components: aspirin, caffeine and periplaneta americana extract. The composition has effects of relieving hangover and hangover, protecting stomach, and relieving stomach discomfort after drinking; and the composition has high efficiency and good quality stability.

Description

Composition and application thereof in sobering-up, hangover-relieving and stomach-protecting

Technical Field

The invention belongs to the technical field of medicines, and particularly relates to a composition and application thereof in sobering up, hangover relieving and stomach protecting.

Background

The history of wine production and consumption in China is long, and the wine almost permeates into various fields in the society. However, excessive drinking can seriously affect the physical health of people and the stability of families and society. Excessive drinking can cause dizziness, nausea, vomiting, and inattention. Long-term drinking can cause mental disorder, gastritis, gastric ulcer, fatty liver, liver cirrhosis, liver cancer and the like.

Hangover means headache, stomach discomfort and other symptoms in the morning of the next day caused by excessive drinking. This is because after drinking a large amount of alcohol, the liver cells cannot treat all the harmful substance acetaldehyde, resulting in acute toxicity symptoms. In hangover, the liver accumulates fat, the stomach and intestine is prone to alcoholic acute gastritis, heart beat acceleration caused by autonomic nerve balance disorder, and water and electrolyte balance disorder in blood affect the whole body.

Therefore, the development of effective anti-hangover drugs has become an important issue.

Disclosure of Invention

In view of the above-mentioned deficiencies in the prior art, a first object of the present invention is to provide a composition, which can relieve hangover and hangover, and protect the stomach while relieving hangover, so that a drinker can quickly get rid of headache and nausea symptoms and effectively protect the gastric mucosa, and alleviate discomfort of the stomach after drinking; and the composition has high efficiency and good quality stability.

In view of the above-mentioned disadvantages of the prior art, the second object of the present invention is to provide a composition for relieving hangover and protecting stomach.

In order to achieve the above purpose, the solution adopted by the invention is as follows:

a composition comprises the following effective components: aspirin, caffeine and periplaneta americana extract.

An application of the above composition in relieving hangover and protecting stomach is provided.

The composition and the application thereof in sobering up, hangover relieving and stomach protecting have the beneficial effects that:

the composition provided by the invention creatively combines aspirin, caffeine and periplaneta americana extract.

Aspirin, when used alone, can act as an analgesic by inhibiting the synthesis of prostaglandins and other substances that sensitize the sensation of pain to mechanical or chemical stimuli, such as post-hangover headaches. When used alone, caffeine can stimulate the central nervous system, and can expel drowsiness and restore energy.

In the invention, aspirin and caffeine are used in combination, and can be cooperated to achieve a more remarkable hangover-alleviating effect, so that discomfort symptoms related to hangover, such as dizziness, headache, nausea and the like, can be effectively relieved. In the application, the anti-inflammatory component in the aspirin and the caffeine are combined to help offset the action of alcohol, so that the anti-hangover effect can be achieved. Meanwhile, the caffeine is used as a central stimulant and can enhance the analgesic effect of aspirin. In addition, one of the main causes of hangover is the acetate of chemical substance "by-product" produced when the human body decomposes alcohol, and the combination of aspirin and caffeine helps to prevent the chemical substance from harming the body, which is more advantageous than the use of aspirin or caffeine alone.

The periplaneta americana extract can effectively protect gastric mucosa, relieve discomfort of the stomach after drinking wine and stimulation of aspirin to the stomach, treat stomachache and gastrorrhagia, has obvious protective effect on pyloric ligation gastric ulcer and anhydrous ethanol gastric ulcer, can obviously reduce the secretion of gastric juice, the total acid output and the pepsin output, and has curative effect on peptic ulcer.

The invention creatively combines the periplaneta americana extract, aspirin and caffeine for use, has the effects of sobering up and relieving hangover, has double stomach protection functions, is suitable for taking after drinking, can effectively sober up, relieve hangover, and relieve hangover, so that drinkers can quickly get rid of headache and nausea symptoms and relieve stomach discomfort after drinking.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

The following is a detailed description of a composition and its application in sobering up and hangover-alleviating stomach protection.

The combination of aspirin and caffeine has remarkable effects of sobering up and relieving hangover, and the Periplaneta americana extract can effectively protect gastric mucosa, does not hurt stomach, and reduces discomfort of stomach after drinking and stimulation of aspirin to stomach.

Periplaneta americana is native to south america and is the largest volume of insects in the blattaceae family. Adult bodies are 29-35mm long, reddish brown, wings are longer than the tail ends of the abdomens, tentacles are very long, large butterfly brown stripes are arranged in the middle of the forebreast backboard, the rear edges of the stripes are provided with complete yellow stripes, and the eating habits are wide.

In this embodiment, the periplaneta americana extract is at least one of periplaneta americana powder, periplaneta americana soft extract and rehabilitation new liquid.

The periplaneta americana powder is from a GAP culture base of the periplaneta americana of the good doctor pharmaceutical industry group, and is ultrafine powder obtained by trapping and killing the periplaneta americana of the blattaceae for several days with high-temperature water vapor in a pollution-free manner under the GAP feeding condition certified by the national drug administration, drying at low temperature under reduced pressure, and grinding by high-frequency vibration through a special degreasing process. The periplaneta Americana soft extract is prepared by extracting dried periplaneta Americana with ethanol for 3 times, mixing extractive solutions, filtering, recovering ethanol, and concentrating. The new rehabilitation liquid is a product approved by the national drug administration on sale for the dried periplaneta americana extract, and the new rehabilitation liquid in the embodiment adopts a new rehabilitation liquid product with the national drug standard Z51021834 produced by Sichuan good doctors Shanxi pharmaceutical industry, Limited liability company.

The periplaneta americana extract component can promote the growth of granulation tissues, quickly repair various ulcers and wound surfaces, resist inflammation, eliminate inflammatory edema and improve the immune function of organisms, has an obvious protective effect on pyloric ligation gastric ulcer and absolute ethyl alcohol gastric ulcer, can obviously reduce the secretion of gastric juice, the total acid output and the pepsin output, has a curative effect on peptic ulcer and can effectively prevent chronic colitis.

In the embodiment, the aspirin accounts for 800 parts by weight, the coffee accounts for 40-200 parts by weight, and the periplaneta americana extract accounts for 50-500 parts by weight. Further preferably, aspirin is 600 parts, coffee is 150 parts, and periplaneta americana extract is 250 parts. All parts in this example refer to the amount of active substance in milligrams per gram of composition. In this embodiment, the composition obtained by blending the above components in parts by weight has more excellent effects of sobering up, relieving hangover and protecting stomach, and the obtained composition has more stable performance.

In this embodiment, the dosage form of the composition includes one of capsules, tablets, granules, powders, suspensions and oral liquids. The dosage form of the composition is prepared by mainly using the active ingredients and adding pharmaceutically acceptable auxiliary materials. In this embodiment, the adjuvant comprises at least one of a filler, a disintegrant, a cosolvent, a suspending agent, a binder, a flavoring agent, and a lubricant.

The features and properties of the present invention are described in further detail below with reference to examples.

Example 1

The embodiment provides a composition, which comprises raw materials of 30g of aspirin, 20g of caffeine and 50g of periplaneta americana powder, and microcrystalline cellulose, sodium carboxymethyl starch and magnesium stearate are added to prepare 100 tablets.

This example provides a method of preparing a composition comprising: respectively sieving the aspirin, caffeine, Periplaneta americana powder, microcrystalline cellulose, sodium carboxymethyl starch and magnesium stearate with 80 mesh sieve, mixing, tabletting, and making into tablet.

Example 2

The embodiment provides a composition, which comprises 60g of aspirin, 15g of caffeine and 25g of periplaneta americana powder as raw materials, and is prepared into 100 tablets by adding microcrystalline cellulose, sodium carboxymethyl starch and magnesium stearate.

Example 3

The embodiment provides a composition, which comprises raw materials of 50g of aspirin, 20g of caffeine and 30g of periplaneta americana powder, and microcrystalline cellulose, sodium carboxymethyl starch and magnesium stearate are added to prepare 100 tablets.

Example 4

The embodiment provides a composition, which comprises raw materials including 75g of aspirin, 20g of caffeine and 5g of periplaneta americana powder, and is prepared into 100 granules by adding starch and aerosil.

This example provides a method of preparing a composition comprising: respectively sieving the aspirin, caffeine, Periplaneta americana powder, starch and silica gel micropowder with 80 mesh sieve, mixing, and making into capsule.

Example 5

The embodiment provides a composition, which comprises raw materials of 40g of aspirin, 10g of caffeine and 50g of rehabilitation new liquid, and is prepared by adding sucrose, aspartame and methyl paraben into 100 bottles of water till the volume is 5000 ml.

This example provides a method of preparing a composition comprising: respectively sieving the aspirin, caffeine, sucrose and aspartame with 80 mesh sieve, sequentially adding into water for dissolving, adding the rehabilitation solution and methyl hydroxybenzoate, stirring, filtering, bottling, sterilizing, and making into oral liquid.

Example 6

The embodiment provides a composition, raw materials of which comprise 80g of aspirin, 4g of caffeine and 16g of periplaneta americana thick paste, mannitol, croscarmellose sodium and aspartame are added, and 100 bags are prepared.

This example provides a method of preparing a composition comprising: respectively sieving the aspirin, caffeine, Periplaneta americana soft extract, mannitol, croscarmellose sodium and aspartame with 80 mesh sieve, mixing, adding ethanol solution to make soft mass, granulating, drying, grading, and packaging to obtain granule.

Comparative example 1

The comparative example provides a composition, raw materials of the composition comprise 28g of aspirin, 21g of caffeine and 51g of periplaneta americana powder, and microcrystalline cellulose, sodium carboxymethyl starch and magnesium stearate are added to prepare 100 tablets.

This comparative example provides a method of preparing a composition comprising: respectively sieving the aspirin, caffeine, Periplaneta americana powder, microcrystalline cellulose, sodium carboxymethyl starch and magnesium stearate with 80 mesh sieve, mixing, tabletting, and making into tablet.

Comparative example 2

The comparative example provides a composition, the active ingredients of which comprise 93g of aspirin, 3g of caffeine and 4g of periplaneta americana powder, and microcrystalline cellulose, sodium carboxymethyl starch and magnesium stearate are added to prepare 100 tablets.

Comparative example 3

The comparative example provides a composition, the active ingredients of which comprise 70g of aspirin, 26g of caffeine and 4g of periplaneta americana powder, and microcrystalline cellulose, sodium carboxymethyl starch and magnesium stearate are added to prepare 100 tablets.

Comparative example 4

The comparative example provides a composition, the active ingredients of which comprise 85g of aspirin, 5g of caffeine and 10g of periplaneta americana powder, and microcrystalline cellulose, sodium carboxymethyl starch and magnesium stearate are added to prepare 100 tablets.

Comparative example 5

The comparative example provides a composition, the active ingredients of which comprise 70g of aspirin and 30g of periplaneta americana powder, and microcrystalline cellulose, sodium carboxymethyl starch and magnesium stearate are added to prepare 100 tablets.

Comparative example 6

The comparative example provides a composition, the effective components of which comprise 50g of caffeine and 50g of periplaneta americana powder, and microcrystalline cellulose, sodium carboxymethyl starch and magnesium stearate are added to prepare 100 tablets.

Experimental example 1

And (3) safety test:

test animals: 24 mice, half male and half female, weighing 16-18 g.

Test materials: the composition provided of example 2 is a tablet.

The test method comprises the following steps: 24 mice were randomly divided into 2 groups of 12 mice each, and each mouse of the test group and the control group was subjected to intragastric administration of tablets and physiological saline once in the morning on an empty stomach, continuously administered for 10 days, blood was collected from the orbit, and sacrificed after blood collection on the 10 th day. Dissecting, accurately weighing each organ of the mouse, performing pathological observation, fixing and flaking heart, liver, spleen, lung and kidney, HE staining, and performing microscopic examination and analysis. Separating serum from the collected blood, and performing biochemical index measurement. The detection indexes are as follows: red Blood Cells (RBC), White Blood Cells (WBC), Glutamic Oxaloacetic Transaminase (GOT), Glutamic Pyruvic Transaminase (GPT), Platelets (PLT), and Hemoglobin (HGB).

Pathological histological examination results:

all mice in the test groups have no obvious change in organs such as heart, liver, spleen, lung, kidney and the like, and the appearance and color of the organs are normal. The tissue sections of each organ are examined under the microscope, and the symptoms of cell vacuole degeneration, cell nucleus necrosis, cell nucleus lysis, cell disappearance and the like are not seen. As is clear from Table 1, no significant difference was observed in the organ coefficients of the test group and the control group.

TABLE 1 measurement results of organ coefficients of mouse (unit:%)

Group of	Heart with heart-shaped	Liver disease	Spleen	Lung (lung)	Kidney (Kidney)
						Control group	0.49±0.05	4.48±0.27	0.37±0.07	0.83±0.12	1.46±0.21
Test group	0.48±0.03	4.38±0.51	0.35±0.05	0.81±0.09	1.44±0.19

Results of hematological tests:

as can be seen from table 2, all test mice sera changed little in RBC, WBC, GOT, GPT, PLT and HGB throughout the test period.

TABLE 2 Biochemical index test results for mice

And (4) conclusion:

the organ coefficients of the mice of the test group and the control group have no obvious difference, the pathological changes and injuries of the organs of the mice are not found in section microscopic examination, the physiological and biochemical values of blood are all in a normal range, and the product has better safety.

Experimental example 2

Test of drug efficacy

Test animals: 100 rats, half male and female, weight 200-.

Test materials: tablets of examples 1 to 3 and comparative examples 1 to 6, aspirin tablets.

The test method comprises the following steps: rats were randomly divided into 10 groups of 10 animals each and gavaged at the doses of table 3 for 3 days 1 time per day. 2 hours after the last administration, rats of each group were each gazed with 1.0ml of 52-degree white wine, and the animals were sacrificed 2 hours later. The pylorus and cardia are ligatured by the abdominal cavity, the whole stomach is picked up and soaked in 10% formaldehyde solution for 30 minutes, the stomach is cut along the greater curvature of the stomach to take out the content of the stomach, the stomach is naturally unfolded by washing the stomach with normal saline, the stomach is sucked dry by filter paper, and the ulcer index is observed and evaluated, and the result is shown in table 3.

TABLE 3 Effect on gastric mucosal injury in rats induced by white spirit administration

Group of	Animal number (only)	Dosage form	Ulcer index (/ cm)²）
				Model control group	10	Equal volume of normal saline	0.054±0.013
Example 1	10	20mg/kg	0.028±0.007
				Example 2	10	20mg/kg	0.032±0.009
Example 3	10	20mg/kg	0.030±0.006
				Comparative example 1	10	20mg/kg	0.037±0.012
Comparative example 2	10	20mg/kg	0.049±0.009
				Comparative example 3	10	20mg/kg	0.051±0.011
Comparative example 4	10	20mg/kg	0.045±0.005
				Comparative example 5	10	20mg/kg	0.040±0.012
Comparative example 6	10	20mg/kg	0.038±0.005
				Aspirin group	10	10mg/kg	0.063±0.018

Table 3 shows that aspirin group had a tendency to aggravate gastric mucosal injury caused by white spirit in rats; whereas the ulcer indexes of examples 1 to 3 and comparative examples 1 to 6 were significantly different (P < 0.05) from the model group; the ulcer indexes of examples 1-3 and comparative examples 1-6 were significantly different (P < 0.01) compared to the aspirin group; and the ulcer indices of examples 1-3 are significantly less than those of comparative examples 1-6. It can be seen that the composition provided by the embodiment of the application has a protective effect on the gastric mucosal injury of rats caused by the administration of white spirit to the rats, and simultaneously has a protective effect on the gastric mucosal injury of rats caused by aspirin. The examples of the present application are superior to the comparative examples in the efficacy results.

Experimental example 3

Sobering up and sobering up test:

test animals: 100 mice, half male and half female, weighing 18-22 g.

Test materials: tablets of examples 1-3 and comparative examples 1-6.

The test method comprises the following steps: 100 mice were randomly divided into 10 groups of 10 mice each, each group being: model groups, examples 1-3 groups, comparative examples 1-6 groups. Mice in each group were fasted for 12 hours prior to the experiment. The tablets of examples 1 to 3 and comparative examples 1 to 6 were administered to the test group at a dose of 5g/kg, respectively, and the model group was administered with an equal amount of physiological saline. After 30 minutes, all mice in each group are drenched with 52-degree white spirit at a concentration of 0.15ml/10 g. The activity of the mice was observed and the number of drunk and the positive reflex turnover were recorded. The time from gavage to complete disappearance of the righting reflex (tolerance time) and the time from disappearance of the righting reflex to recovery (drunk maintenance time) were calculated. The test results are shown in Table 4.

TABLE 4 antialcoholism test

Group of	Animal number (only)	Drunk number (only)	Endurance time (min)	Drunk maintenance time (min)
					Model set	10	10	12.14±3.58	461.75±32.96
Example 1	10	9	54.91±12.63	203.52±36.19
					Example 2	10	7	70.32±8.11	164.97±31.84
Example 3	10	8	59.05±6.77	180.08±25.77
					Comparative example 1	10	10	28.76±5.01	397.64±31.09
Comparative example 2	10	10	31.57±9.69	376.01±38.23
					Comparative example 3	10	10	40.61±9.35	315.27±44.15
Comparative example 4	10	10	36.96±7.22	359.86±30.97
					Comparative example 5	10	10	25.43±4.96	405.33±36.71
Comparative example 6	10	10	22.59±3.78	428.19±40.52

The results in table 4 show that, compared with the model group, examples 1 to 3 can reduce the number of mice intoxicated, remarkably prolong the tolerance time (P < 0.01), remarkably shorten the intoxication maintaining time (P < 0.01), and achieve the sobering-up effect. None of comparative examples 1-6 reduced the number of mice intoxicated compared to the model group, and there was no significant difference in the duration of tolerance and intoxication maintenance (P > 0.05).

The data in tables 3 and 4 show that the stomach protecting effect of comparative examples 1, 5 and 6 is better, but the sobering and alcoholism relieving effects are very poor; comparative examples 2, 3 and 4 were improved to some extent in the tolerance time and the intoxication-sustaining time, but the stomach-protecting effect was not significant. Therefore, the composition prepared by adopting the effective components provided by the embodiment of the application in the proportioning range has remarkable effects of relieving alcoholism and hangover and relieving hangover, has remarkable stomach protection effect, and is high in efficiency and good in quality stability.

In conclusion, the composition provided by the invention can relieve alcoholism and hangover and protect the stomach while relieving hangover, so that a drinker can quickly get rid of symptoms of headache and nausea and effectively protect gastric mucosa, and discomfort of the stomach after drinking is relieved; and the composition has high efficiency and good quality stability.

The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A composition characterized by: the effective components of the composition comprise: aspirin, caffeine and periplaneta americana extract.

2. The composition of claim 1, wherein: the aspirin accounts for 800 parts by weight, the coffee accounts for 40-200 parts by weight, and the periplaneta americana extract accounts for 50-500 parts by weight.

3. The composition of claim 1, wherein: the aspirin is 600 parts, the coffee is 150 parts, and the periplaneta americana extract is 250 parts according to the parts by weight.

4. The composition of claim 2, wherein: the periplaneta americana extract comprises at least one of periplaneta americana powder, periplaneta americana thick paste and rehabilitation new liquid.

5. The composition of claim 2, wherein: the dosage form comprises one of capsules, tablets, granules, powder, suspension and oral liquid.

6. Use of a composition according to any one of claims 1 to 5 for sobering up and hangover protection in the stomach.