CN112028795A - Synthesis method of metformin hydrochloride - Google Patents
Synthesis method of metformin hydrochloride Download PDFInfo
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- CN112028795A CN112028795A CN202010982521.7A CN202010982521A CN112028795A CN 112028795 A CN112028795 A CN 112028795A CN 202010982521 A CN202010982521 A CN 202010982521A CN 112028795 A CN112028795 A CN 112028795A
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- Prior art keywords
- metformin hydrochloride
- reaction
- hydrochloride
- dicyandiamide
- synthesizing
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Abstract
The invention discloses a synthetic method of metformin hydrochloride, which is characterized in that dimethylamine hydrochloride and dicyandiamide are used as raw materials, an organic solvent is used as a dispersing agent to react under 0.25-0.3 MPa to obtain the metformin hydrochloride, the reaction steps are redesigned, the reaction time is shortened, the reaction yield is high, and finally the obtained product is similar white, the total yield reaches more than 90%, the yield is high, and the product quality is good.
Description
Technical Field
The invention relates to a synthetic method of metformin hydrochloride, belonging to the technical field of organic synthesis.
Background
Metformin hydrochloride is a biguanide hypoglycemic drug, has a long history of use, and has good hypoglycemic effect and safety. The metformin hydrochloride is used for type II diabetics with unsatisfactory simple diet control, especially obese and hyperinsulinemia-accompanied diabetics, and has the effects of reducing blood sugar and possibly reducing weight and hyperinsulinemia. Can be used for treating patients with poor curative effect of some sulfonylureas, such as sulfonylureas, small intestine glycosidase inhibitor or thiazolidinedione hypoglycemic agent, which has better effect than single use. Can also be used for patients with insulin therapy to reduce insulin dosage.
In patent document CN105968032B, dimethylamine, dicyandiamide, hydrochloric acid solution and catalytic organic acid are used as starting materials in a high-pressure closed environment, and metformin hydrochloride itself is a water-soluble substance, so that almost all of the product is dissolved in water, and the product is obtained by subsequent purification, but some of the product is lost.
Disclosure of Invention
Aiming at the technical problems, the invention aims to provide another method for synthesizing metformin hydrochloride, which directly obtains a metformin hydrochloride product by using an organic solvent as a dispersing agent, and has high yield and good product quality.
In order to achieve the purpose, the technical scheme of the invention is as follows: the method for synthesizing metformin hydrochloride is characterized in that dimethylamine hydrochloride and dicyandiamide are used as raw materials, and an organic solvent is used as a dispersing agent to react under 0.25-0.3 MPa to obtain the metformin hydrochloride.
In the scheme, the method comprises the following steps: the high-pressure reaction time is 1-2 hours, and the reaction temperature is 120-140 ℃.
In the scheme, the method comprises the following steps: the molar ratio of dimethylamine hydrochloride to dicyandiamide is 1-1.2: 1.
In the scheme, the method comprises the following steps: the solvent used is one or two mixed solvents of DMF, toluene, N-methyl pyrrolidone, DMSO, DMAC, isoamylol, N-amyl alcohol and ethylene glycol monomethyl ether.
In the scheme, the method comprises the following steps: after the reaction is finished, cooling to 50-60 ℃ for crystallization, centrifuging, washing and drying to obtain a metformin hydrochloride crude product.
Has the advantages that: the invention provides a method for obtaining metformin hydrochloride by taking dimethylamine hydrochloride and dicyandiamide as raw materials and using an organic solvent as a dispersant to react under a high-pressure reaction condition, through redesigning the reaction steps, the reaction time is shortened, the reaction yield is high, and finally the obtained product is similar to white, the total yield reaches more than 90 percent, the yield is high, and the product quality is good.
Detailed Description
The invention will now be further illustrated by reference to the following examples:
example 1
Synthesis of metformin hydrochloride
196g (2.4mol) of dimethylamine hydrochloride, 168g (2mol) of dicyandiamide and 500g of N-methylpyrrolidone are put into a high-pressure reaction kettle, the temperature is increased to 130 ℃ for reaction for 1 hour, the reaction pressure is 0.25-0.3 MPa, the temperature is reduced to 50-60 ℃ after the reaction is finished, the mixture is stirred for 1 hour, centrifugal drying is carried out, solid is obtained, and the solid is dried under reduced pressure to obtain 303g of crude metformin hydrochloride, wherein the yield is 92%.
Example 2
Synthesis of metformin hydrochloride
196g (2.4mol) of dimethylamine hydrochloride, 168g (2mol) of dicyandiamide and DMSO500g are put into a high-pressure reaction kettle, the temperature is increased to 130 ℃ for reaction for 1.5 hours, the reaction pressure is 0.25-0.3 MPa, the temperature is reduced to 50-60 ℃ after the reaction is finished, the mixture is stirred for 1 hour and centrifuged to be dried, and solid is obtained and dried under reduced pressure to obtain 302g of crude metformin hydrochloride, wherein the yield is 91.7%.
Example 3
Synthesis of metformin hydrochloride
196g (2.4mol) of dimethylamine hydrochloride, 168g (2mol) of dicyandiamide and DMF500g are put into a high-pressure reaction kettle, the temperature is increased to 130 ℃ for reaction for 1 hour, the reaction pressure is 0.25-0.3 MPa, the temperature is reduced to 50-60 ℃ after the reaction is finished, the mixture is stirred for 1 hour and centrifugally dried, and solid obtained is dried under reduced pressure to obtain 300g of crude metformin hydrochloride, wherein the yield is 91.1%.
Example 4
Synthesis of metformin hydrochloride
196g (2.4mol) of dimethylamine hydrochloride, 168g (2mol) of dicyandiamide and 500g of toluene are put into a high-pressure reaction kettle, the temperature is increased to 130 ℃ for reaction for 1.5 hours, the reaction pressure is 0.25-0.3 MPa, the temperature is reduced to 50-60 ℃ after the reaction is finished, the mixture is stirred for 1 hour and centrifugally dried, solid is obtained, and the solid is dried under reduced pressure to obtain 301g of a metformin hydrochloride crude product, wherein the yield is 91.4%.
Example 5
Synthesis of metformin hydrochloride
196g (2.4mol) of dimethylamine hydrochloride, 168g (2mol) of dicyandiamide and 500g of DMAC (dimethylacetamide) are put into a high-pressure reaction kettle, the temperature is increased to 130 ℃ for reaction for 1.5 hours, the reaction pressure is 0.25-0.3 MPa, the temperature is reduced to 50-60 ℃ after the reaction is finished, the mixture is stirred for 1 hour and centrifuged to be dried, solid is obtained, and the solid is dried under reduced pressure to obtain 297g of metformin hydrochloride crude product, wherein the yield is 90.2%.
Example 6
Synthesis of metformin hydrochloride
196g (2.4mol) of dimethylamine hydrochloride, 168g (2mol) of dicyandiamide and 500g of isoamylol are put into a high-pressure reaction kettle, the temperature is increased to 130 ℃ for reaction for 1.5 hours, the reaction pressure is 0.25-0.3 MPa, the temperature is reduced to 50-60 ℃ after the reaction is finished, the mixture is stirred for 1 hour and centrifugally dried, solid is obtained, and the solid is dried under reduced pressure to obtain 299g of metformin hydrochloride crude product, wherein the yield is 90.7%.
Example 7
Synthesis of metformin hydrochloride
196g (2.4mol) of dimethylamine hydrochloride, 168g (2mol) of dicyandiamide and 500g of n-amyl alcohol are put into a high-pressure reaction kettle, the temperature is increased to 130 ℃ for reaction for 1 hour, the reaction pressure is 0.25-0.3 MPa, the temperature is reduced to 50-60 ℃ after the reaction is finished, the mixture is stirred for 1 hour and centrifugally dried, and the solid obtained is dried under reduced pressure to obtain 298g of metformin hydrochloride crude product, wherein the yield is 90.5%.
Example 8
Synthesis of metformin hydrochloride
196g (2.4mol) of dimethylamine hydrochloride, 168g (2mol) of dicyandiamide and 500g of ethylene glycol monomethyl ether are put into a high-pressure reaction kettle, the temperature is increased to 130 ℃ for reaction for 1 hour, the reaction pressure is 0.25-0.3 MPa, the temperature is reduced to 50-60 ℃ after the reaction is finished, the mixture is stirred for 1 hour and centrifugally dried, and solid is obtained and dried under reduced pressure to obtain 300g of metformin hydrochloride crude product with the yield of 91.1%.
Example 9
Synthesis of metformin hydrochloride
196g (2.4mol) of dimethylamine hydrochloride, 168g (2mol) of dicyandiamide, 300g of DMSO and 200g of N-methylpyrrolidone are put into a high-pressure reaction kettle, the temperature is increased to 130 ℃ for reaction for 1.5 hours, the reaction pressure is 0.25-0.3 MPa, the temperature is reduced to 50-60 ℃ after the reaction is finished, the stirring is carried out for 1 hour, the centrifugal drying is carried out, solid is obtained, the pressure reduction drying is carried out, 313g of metformin hydrochloride crude product is obtained, and the yield is 95.1%.
The present invention is not limited to the above-described embodiments, and those skilled in the art will understand that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.
Claims (5)
1. The method for synthesizing metformin hydrochloride is characterized in that dimethylamine hydrochloride and dicyandiamide are used as raw materials, and an organic solvent is used as a dispersing agent to react under 0.25-0.3 MPa to obtain the metformin hydrochloride.
2. The method for synthesizing metformin hydrochloride according to claim 1, wherein: the high-pressure reaction time is 1-2 hours, and the reaction temperature is 120-140 ℃.
3. The method for synthesizing metformin hydrochloride according to claim 1, wherein: the molar ratio of dimethylamine hydrochloride to dicyandiamide is 1-1.2: 1.
4. The method for synthesizing metformin hydrochloride according to claim 1, wherein: the solvent used is one or two mixed solvents of DMF, toluene, N-methyl pyrrolidone, DMSO, DMAC, isoamylol, N-amyl alcohol and ethylene glycol monomethyl ether.
5. The method for synthesizing metformin hydrochloride according to any one of claims 1 to 4, wherein: after the reaction is finished, cooling to 50-60 ℃ for crystallization, centrifuging, washing and drying to obtain a metformin hydrochloride crude product.
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| CN202010982521.7A CN112028795A (en) | 2020-09-17 | 2020-09-17 | Synthesis method of metformin hydrochloride |
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| CN202010982521.7A CN112028795A (en) | 2020-09-17 | 2020-09-17 | Synthesis method of metformin hydrochloride |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022241978A1 (en) * | 2021-05-21 | 2022-11-24 | 海南海力制药有限公司 | Method for synthesizing metformin hydrochloride and application thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110021634A1 (en) * | 2009-06-18 | 2011-01-27 | Patel Pranav Dushyant | Processes for preparing metformin hydrochloride |
| CN102516130A (en) * | 2011-11-26 | 2012-06-27 | 赤峰万泽制药有限责任公司 | Preparation method of metformin hydrochloride |
| CN103435518A (en) * | 2013-08-26 | 2013-12-11 | 青岛黄海制药有限责任公司 | Preparation method of metformin hydrochloride |
| CN104119250A (en) * | 2014-07-15 | 2014-10-29 | 徐晓宁 | Production method of high-purity metformin hydrochloride |
| CN105481726A (en) * | 2015-12-17 | 2016-04-13 | 石家庄市普力制药有限公司 | Preparation method of metformin hydrochloride |
| CN105968032A (en) * | 2016-05-12 | 2016-09-28 | 宁夏思科达生物科技有限公司 | Synthetic method of metformin hydrochloride |
| CN106278953A (en) * | 2015-04-24 | 2017-01-04 | 泰山医学院 | A kind of production method improving metformin hydrochloride purity |
| CN107445869A (en) * | 2017-07-18 | 2017-12-08 | 山东科源制药股份有限公司 | A kind of synthetic method of Metformin hydrochloride |
-
2020
- 2020-09-17 CN CN202010982521.7A patent/CN112028795A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110021634A1 (en) * | 2009-06-18 | 2011-01-27 | Patel Pranav Dushyant | Processes for preparing metformin hydrochloride |
| CN102516130A (en) * | 2011-11-26 | 2012-06-27 | 赤峰万泽制药有限责任公司 | Preparation method of metformin hydrochloride |
| CN103435518A (en) * | 2013-08-26 | 2013-12-11 | 青岛黄海制药有限责任公司 | Preparation method of metformin hydrochloride |
| CN104119250A (en) * | 2014-07-15 | 2014-10-29 | 徐晓宁 | Production method of high-purity metformin hydrochloride |
| CN106278953A (en) * | 2015-04-24 | 2017-01-04 | 泰山医学院 | A kind of production method improving metformin hydrochloride purity |
| CN105481726A (en) * | 2015-12-17 | 2016-04-13 | 石家庄市普力制药有限公司 | Preparation method of metformin hydrochloride |
| CN105968032A (en) * | 2016-05-12 | 2016-09-28 | 宁夏思科达生物科技有限公司 | Synthetic method of metformin hydrochloride |
| CN107445869A (en) * | 2017-07-18 | 2017-12-08 | 山东科源制药股份有限公司 | A kind of synthetic method of Metformin hydrochloride |
Non-Patent Citations (2)
| Title |
|---|
| 倪生良等: "盐酸二甲双胍合成工艺改进", 《内蒙古石油化工》 * |
| 许同桃等: "盐酸二甲双胍的合成工艺研究", 《化工时刊》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022241978A1 (en) * | 2021-05-21 | 2022-11-24 | 海南海力制药有限公司 | Method for synthesizing metformin hydrochloride and application thereof |
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Application publication date: 20201204 |