CN112022168B - White mouse tail-breaking hemostix - Google Patents
White mouse tail-breaking hemostix Download PDFInfo
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- CN112022168B CN112022168B CN202010753706.0A CN202010753706A CN112022168B CN 112022168 B CN112022168 B CN 112022168B CN 202010753706 A CN202010753706 A CN 202010753706A CN 112022168 B CN112022168 B CN 112022168B
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- tail
- mouse
- water bath
- chamber
- blood
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
- A61B5/150061—Means for enhancing collection
- A61B5/150076—Means for enhancing collection by heating
Abstract
The invention provides a tail-broken blood collector for mice, belonging to the technical field of experimental instruments. It has solved the problem that the volume of taking blood is few when current mice broken the tail and collect blood. The tail-breaking hemostix for the mice comprises a base and a mouse bin, wherein a mouse tail extending port is formed in the tail of the mouse bin, a connecting pipe is arranged outside the mouse bin, two ends of the connecting pipe are communicated, the inner end of the connecting pipe is in butt joint with the mouse tail extending port, a hollow interlayer is arranged on the side wall of the mouse bin, a water bath pipe is arranged inside the connecting pipe, a water bath interlayer is arranged on the side wall of the water bath pipe, one end of the water bath interlayer is in butt joint communication with the hollow interlayer, the other end of the water bath pipe is connected with a twisting mechanism, the water bath pipe is made of a flexible material, and the water bath pipe can be twisted under the control of the twisting mechanism. This mice severed tail hemostix can utilize the water bath pipe that is full of the warm water to wrap up the heating to the rat tail at the blood sampling in-process, can not wet the rat tail, makes the blood vessel keep full, improves blood sampling efficiency.
Description
Technical Field
The invention belongs to the technical field of experimental instruments, and relates to a tail-broken blood collector for mice.
Background
Because the gene sequence of mouse is similar to that of human, some medical research and clinical experiments are completed by mouse. In the whole experiment process, the mice are often required to be subjected to blood sampling for multiple times, and the conventional blood sampling methods are basically divided into 4 types: firstly, blood is collected from the orbit, namely a capillary tube is used for puncturing the orbit of the mouse; secondly, tail blood collection, namely cutting the tail of the mouse by using scissors to collect blood; thirdly, breaking the head to collect blood; fourth, jugular vein blood sampling.
In the first orbital blood collection, the blood collection amount is more than that of the tail blood collection, but the white mouse is easy to blind due to improper operation; the second tail blood sampling can be carried out for a plurality of times, but the blood sampling time is longer and the blood volume is less. The third method is to take blood with broken head, which is most effective in taking blood, but not beneficial to taking blood for many times. The fourth jugular vein blood sampling requires very high requirements on operators, and is not easy to grasp by general experimenters.
For the second tail blood sampling, the existing tail-breaking blood sampling method has the defects of long blood sampling time and small blood sampling amount, so blood vessels at the tail of a mouse are full before blood sampling, the adopted method is generally hot water heating, the tail of the mouse needs to be soaked in hot water, the operation is very inconvenient after the mouse is fixed, the mouse tail needs to be wiped clean after being taken out, the mouse tail becomes cool in the wiping process, and the effect is general.
Disclosure of Invention
The invention aims to solve the problems of the conventional blood sampling of mice, and provides a mouse tail breaking hemostix which can continuously heat a mouse tail in a water bath during the blood sampling process.
The purpose of the invention can be realized by the following technical scheme:
the utility model provides a mice tail-breaking hemostix, includes base and mouse storehouse, and the mouse storehouse is fixed to be set up on the base and inside has the inner chamber that holds the mice of waiting to take a blood sample, and the afterbody in mouse storehouse has the mouse tail and stretches out the mouth, and its characterized in that, the outside in mouse storehouse is equipped with a takeover, and this takeover both ends link up, and the inner docks with above-mentioned mouse tail stretching out mouth, the lateral wall in mouse storehouse has the cavity intermediate layer, and the inside of takeover is equipped with a water bath pipe, and the both ends of water bath pipe link up in order to pass the mouse tail, and the lateral wall of water bath pipe has the water bath intermediate layer, and the one end of this water bath intermediate layer and the butt joint intercommunication of above-mentioned cavity intermediate layer, and the other end of water bath pipe is connected with a twisting mechanism, and the water bath pipe adopts flexible material to make, the water bath pipe can be twisted under the control of above-mentioned twisting mechanism, and open on the lateral wall of mouse storehouse and be used for the water filling port in the cavity intermediate layer.
In foretell mouse broken tail hemostix, twist commentaries on classics mechanism and include annular knob, the knob cover is established in the takeover outside, the outer port of above-mentioned water bath pipe turns over to the book the back outwards and knob circumference fixed connection, the axial is opened on the lateral wall of takeover has the guide slot, the side interval of guide slot sets up many draw-in grooves, the one end of each draw-in groove all communicates with the guide slot, the fixed fixture block that sets up on the inside wall of knob, the fixture block card is established in draw-in groove or guide slot to can follow draw-in groove and guide slot back and forth movement, many draw-in grooves all are arc and parallel interval and set up.
In the above-mentioned white mouse tail-breaking hemostix, the other end of the clamping groove is provided with a locking pit.
In the above-mentioned mice broken tail hemostix, the hemostix still include a mount, above-mentioned base rotates and sets up on this mount, the junction of base and mount sets up locking device.
In foretell mice broken tail hemostix, the mouse storehouse including the components of a whole that can function independently preceding storehouse and the back storehouse of setting, the afterbody of preceding storehouse and the anterior portion of back storehouse are all opened, and the back storehouse front portion can dock in preceding storehouse rear portion, and above-mentioned cavity intermediate layer and mouse tail stretch out the mouth and are located the back storehouse.
In foretell mouse broken tail hemostix, the continuous reverse bending type in middle part in preceding storehouse forms multichannel fold, multichannel the fold can stretch and contract at length direction, and each fold department sets up buckle or card hole, sets up the pothook on the back storehouse, and the one end of pothook is through stay cord and back storehouse fixed connection, and the hook portion of pothook can be hooked the bayonet socket or the card hole department on any fold.
In the above-mentioned white mouse tail-breaking hemostix, the size of the rear bin opening is larger than the size of the front bin tail.
Compared with the prior art, this mice broken tail hemostix can utilize the water bath pipe that is full of the warm water to wrap up the heating to the rat tail at the blood sampling in-process, can not wet the rat tail, makes the blood vessel keep full of, improves blood sampling efficiency. The length of the water bath pipe used for wrapping the effective part of the rat tail can be adjusted, and the water bath pipe can be suitable for blood sampling of different rats or multiple tail-breaking operations of the same rat, and is wide in applicability.
Drawings
Fig. 1 is a schematic structural view of the present invention.
Fig. 2 is a schematic view of the structure of the adapter tube.
Fig. 3 is a schematic view of the knob.
In the figure, 1, a base; 2. a mouse chamber; 3. a front bin; 4. a rear bin; 5. a hollow interlayer; 6. a tail extension port; 7. taking over a pipe; 8. a guide groove; 9. a card slot; 10. a locking recess; 11. a water injection port; 12. a knob; 13. a clamping block; 14. a water bath tube; 15. water bath interlayer; 16. and (4) wrinkling.
Detailed Description
The following are specific embodiments of the present invention and are further described with reference to the drawings, but the present invention is not limited to these embodiments.
As shown in fig. 1, the device for collecting blood from mice with severed tails comprises a base 1 and a rat bin 2, wherein the base 1 is arranged on a fixed frame, the base 1 is rotatably connected with the fixed frame, so that the base 1 can rotate relative to the fixed frame to enable the rat bin 2 to be placed transversely or erected, and after the base is adjusted in place, the base is fastened by a locking device which can be a fastening knob 12, a fastening bolt or other common locking modes.
Rear bin 4 is bilayer structure, cavity intermediate layer 5 has in lateral wall and the bottom plate, rear bin 4's tip (on the bottom plate) is opened has the sage to stretch out mouthful 6, this sage stretches out a 6 butt joint and takes over 7, as shown in fig. 2, take over 7 both ends and link up, it has sharp guide slot 8 to open axially on the lateral wall, the side interval of this guide slot 8 sets up many draw-in grooves 9, each draw-in groove 9 is the arc and the interval setting that is parallel to each other, the one end of draw-in groove 9 is unified and the guide slot 8 communicates, the other end all is equipped with locking pit 10. And a water filling port 11 for filling water into the hollow interlayer 5 is formed in the side wall of the mouse chamber 2.
As shown in fig. 3, an annular knob 12 is sleeved outside the adapter tube 7, the inner diameter of the knob 12 is close to the outer diameter of the adapter tube 7, a raised block 13 is arranged on the inner wall of the knob 12, and the block 13 can be clamped in the slot 9 or the guide slot 8 and can move back and forth along the slot 9 and the guide slot 8.
A water bath pipe 14 is arranged in the connecting pipe 7, two ends of the water bath pipe 14 are communicated for the tail of the mouse to pass through, a water bath interlayer 15 is arranged on the side wall of the water bath pipe 14, one end of the water bath interlayer 15 is in butt joint communication with the hollow interlayer 5, and the other end of the water bath interlayer 15 extends out of the connecting pipe 7 and is fixedly connected with the knob 12 in the circumferential direction after being turned outwards. The water bath tube 14 is made of a flexible material, preferably a plastic film or the like, and can transmit heat relatively well.
Preceding storehouse 3 middle part is reverse buckling in succession and is formed multichannel fold 16, multichannel fold 16 can stretch out and contract in length direction, and each fold 16 department sets up buckle or card hole, sets up the pothook on the back storehouse 4, and the one end of pothook is through stay cord and 4 fixed connection in back storehouse, and the hook portion of pothook can be linked to bayonet socket or the card hole department on any fold 16, the size of 4 openings in back storehouse is greater than the size of 3 afterbody in front of.
When the mouse is used, the mouse chamber 2 is firstly placed horizontally, the rear chamber 4 is separated from the front chamber 3, a mouse is plugged into the front chamber 3 from the separation position, and the mouse tail extends out after passing through the connecting pipe 7 and the water bath pipe 14. Later insert preceding 3 afterbody in storehouse to the opening of back storehouse 4, the fold 16 of tip can play limiting displacement, then the 16 positions of fold of storehouse 3 before the compression, 3 length in storehouse before the regulation to make whole rat storehouse 2 size equal with the mice size, adjust the back that finishes, go into the pothook card in buckle or the jack, prevent that fold 16 from restoring to the throne under self elasticity effect.
After mouse loading is finished, the base 1 and the mouse chamber 2 are rotated to enable the head of the mouse chamber 2 to face upwards and fixed, and the water injection port 11 faces upwards at the moment. Warm water is injected into the hollow interlayer 5 through the water injection port 11, and the water bath interlayer 15 is also filled with the warm water to swell. Then, the knob 12 is rotated, the water bath tube 14 is driven by the knob 12 to be twisted, the inner diameter of the water bath tube 14 can be contracted when being twisted, the water bath tube is attached to the rat tail to coat the rat tail, blood vessels at the rat tail are heated and filled, the coating force is adjustable, and after the water bath tube is heated for a period of time, the operation of tail breaking and blood sampling can be carried out. If necessary, heating can be carried out at the hollow interlayer 5 to ensure the constant water temperature.
It is to be understood that in the claims, the specification of the present invention, all "including … …" are to be interpreted in an open-ended sense, i.e., in a sense equivalent to "including at least … …", and not in a closed sense, i.e., in a sense not to be interpreted as "including only … …".
The specific embodiments described herein are merely illustrative of the spirit of the invention. Various modifications or additions may be made to the described embodiments or alternatives may be employed by those skilled in the art without departing from the spirit or ambit of the invention as defined in the appended claims.
Claims (6)
1. A tail-breaking hemostix for mice comprises a base (1) and a mouse chamber (2), wherein the mouse chamber (2) is fixedly arranged on the base (1) and is internally provided with an inner cavity for accommodating the mice to be sampled, the tail part of the mouse chamber (2) is provided with a mouse tail extending port (6), the tail-breaking hemostix is characterized in that the outer part of the mouse chamber (2) is provided with a connecting pipe (7), two ends of the connecting pipe (7) are communicated, the inner end of the connecting pipe is in butt joint with the mouse tail extending port (6), the side wall of the mouse chamber (2) is provided with a hollow interlayer (5), the inner part of the connecting pipe (7) is provided with a water bath pipe (14), two ends of the water bath pipe (14) are communicated to pass through the mouse tail, the side wall of the water bath pipe (14) is provided with a water bath interlayer (15), one end of the water bath interlayer (15) is in butt joint and communication with the hollow interlayer (5), the other end of the water bath pipe (14) is connected with a twisting mechanism, and the water bath pipe (14) is made of flexible material, the water bath pipe (14) can be screwed under the control of the screwing mechanism, and a water injection port (11) for injecting water into the hollow interlayer (5) is formed in the side wall of the mouse chamber (2);
twist and change mechanism include annular knob (12), knob (12) cover is established in the takeover (7) outside, the outer port of above-mentioned water bath pipe (14) is to turning over the book back and knob (12) circumference fixed connection outward, the axial is opened on the lateral wall of takeover (7) has guide slot (8), the side interval of guide slot (8) sets up many draw-in grooves (9), the one end of each draw-in groove (9) all communicates with guide slot (8), fixed fixture block (13) that set up on the inside wall of knob (12), fixture block (13) card is established in draw-in groove (9) or guide slot (8), and can follow draw-in groove (9) and guide slot (8) round trip movement, many draw-in grooves (9) all are arc and parallel interval and set up.
2. The device for collecting the blood after the tail of the white mouse is broken according to claim 1, wherein the other end of the slot (9) is provided with a locking pit (10).
3. The device for collecting blood from the severed tail of a white mouse according to claim 1, further comprising a fixing frame, wherein the base (1) is rotatably disposed on the fixing frame, and a locking device is disposed at the joint of the base (1) and the fixing frame.
4. The device for collecting the blood after the tail of the white mouse is broken according to claim 1, wherein the mouse chamber (2) comprises a front chamber (3) and a rear chamber (4) which are separately arranged, the tail part of the front chamber (3) and the front part of the rear chamber (4) are both open, the front part of the rear chamber (4) can be butted with the rear part of the front chamber (3), and the hollow interlayer (5) and the mouse tail extension port (6) are positioned on the rear chamber (4).
5. The device for collecting the blood after the tail of the white mouse is broken according to claim 4, wherein the middle part of the front chamber (3) is continuously and reversely bent to form a plurality of folds (16), the plurality of folds (16) can be stretched and contracted in the length direction, each fold (16) is provided with a buckle or a clamping hole, the rear chamber (4) is provided with a hook, one end of the hook is fixedly connected with the rear chamber (4) through a pull rope, and the hook part of the hook can be hooked at the bayonet or the clamping hole on any fold (16).
6. A device for collecting the blood from the tail of a white mouse according to claim 5, wherein the opening of the rear chamber (4) is larger than the tail of the front chamber (3).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010753706.0A CN112022168B (en) | 2020-07-30 | 2020-07-30 | White mouse tail-breaking hemostix |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010753706.0A CN112022168B (en) | 2020-07-30 | 2020-07-30 | White mouse tail-breaking hemostix |
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| Publication Number | Publication Date |
|---|---|
| CN112022168A CN112022168A (en) | 2020-12-04 |
| CN112022168B true CN112022168B (en) | 2022-04-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202010753706.0A Active CN112022168B (en) | 2020-07-30 | 2020-07-30 | White mouse tail-breaking hemostix |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0301697A2 (en) * | 1987-07-27 | 1989-02-01 | Pipe Liners, Inc. | A method and apparatus for producing a deformed pipe liner of tubular cross-section. |
| CN104368216A (en) * | 2014-11-13 | 2015-02-25 | 常州市华贤五金厂 | Water-bath type air source pretreatment device |
| CN111281594A (en) * | 2020-03-04 | 2020-06-16 | 昆明医科大学 | Rat tail vein blood sampling device |
-
2020
- 2020-07-30 CN CN202010753706.0A patent/CN112022168B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0301697A2 (en) * | 1987-07-27 | 1989-02-01 | Pipe Liners, Inc. | A method and apparatus for producing a deformed pipe liner of tubular cross-section. |
| CN104368216A (en) * | 2014-11-13 | 2015-02-25 | 常州市华贤五金厂 | Water-bath type air source pretreatment device |
| CN111281594A (en) * | 2020-03-04 | 2020-06-16 | 昆明医科大学 | Rat tail vein blood sampling device |
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| CN112022168A (en) | 2020-12-04 |
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