CN112021699A

CN112021699A - Probiotic capsule mask

Info

Publication number: CN112021699A
Application number: CN202010952244.5A
Authority: CN
Inventors: 韩郸; 赵丹妮
Original assignee: Shanghai Changsheng Biotechnology Co ltd
Current assignee: Shanghai Changsheng Biotechnology Co ltd
Priority date: 2020-09-11
Filing date: 2020-09-11
Publication date: 2020-12-04

Abstract

The application belongs to the field of biomedicine, and discloses a probiotic capsule mask, which comprises a mask body and an accessory for fixing the mask on a mouth and nose part, wherein the mask body comprises a textile layer, the accessory is connected with the textile layer, and a carrier layer coated with probiotics is arranged on one side, close to the mouth and nose part, of the textile layer; the carrier layer coated with the probiotics contains a carrier coated with the probiotics; the carrier coated with the probiotics is one or more of zeolite, bentonite, kaolin, clay and activated carbon containing the probiotics, and is fixed with the textile fabric layer in a sticking, inlaying, adsorbing, hot-pressing or sewing mode; the carrier layer coated with probiotics is shaped to match the oronasal position. The mask has good air permeability, and can effectively reduce the phenomena of allergy, acne and the like. The application also comprises a preparation method and application of the mask.

Description

Probiotic capsule mask

Technical Field

The application belongs to the field of biomedicine, and particularly relates to a mask containing a load probiotic carrier. The application also comprises a preparation method and application of the mask.

Background

The mask, as the name implies, is an article for covering the mouth. The mask is generally worn on the mouth and nose to filter air entering the mouth and nose so as to achieve the effect of blocking harmful gas, smell, spray, virus and other substances, and is made of gauze, paper and the like. The mask has a certain filtering function on air entering the lung, and has a very good effect when being worn in respiratory infectious diseases and working in environments polluted by dust and the like.

Common masks are classified into three major categories according to their use: the mask for daily use is mainly made of a layer of textile fabric, can be used for keeping warm or covering the face in winter, and is good and cheap in air permeability, but poor in dustproof and antibacterial effects; medical masks, which are usually made of cotton cloth, nonwoven fabric, or the like, are effective in preventing bacteria and preventing infection of germs caused by spraying (e.g., preventing the spread of germs caused by sneezing); the N95 and other dustproof bacteria filtering masks have the filtering efficiency of over 95 percent for particles with aerodynamic diameters of more than or equal to 0.3 mu m, the aerodynamic diameters of air bacteria and fungal spores are mainly changed between 0.7 and 10 mu m and are within the protection range of the N95 mask, and the N95 mask has good protection effect on viruses but has higher cost.

The PM2.5 air hazard concept brings attention to the air pollution problem to the public, so that protective articles such as masks are sold in the haze weather. Wearing the mask helps to prevent the spread of viruses, which is well known in epidemic prevention and control today. Under the control of new coronavirus, almost people wear the mask for a long time in public transportation, closed space and various densely populated places. The mask is a daily product in our life. With the occurrence of new coronary pneumonia, haze, SARS virus and other hazards, people increasingly realize the importance of the mask, do not carry the mask, and are afraid of going out easily even if the mask does not reach the cun step and is difficult to operate. For example, many densely populated indoor locations have mandated wearing masks.

However, people feel uncomfortable after wearing the mask for a long time for a plurality of months, and particularly, people feel warm gradually and feel hot in the weather, and sweat can flow down the back without wearing the mask. Therefore, many people who need to take a vehicle or work in public places have symptoms such as stuffiness, allergy, eruption, and pox, and there are also tragic trainees reporting that students wear masks in classrooms to cause death. Some people take off the mask when the people risk washing dust or being isolated and treated, but the people are prohibited to enter the area where the mask is forcibly worn, and the risk of suffering from the diseases per se is also increased sharply. Particularly, for some people with poor immunity, the people are easy to be infected without wearing the mask, and the skin is easy to be allergic when wearing the mask, which causes difficulty.

Therefore, a mask which is light, thin, comfortable and good in air permeability is urgently needed under the condition that viruses and haze are abused.

Disclosure of Invention

The technical problem that this application will be solved provides a gauze mask that gas permeability is good, is difficult for taking place unfavorable conditions such as vexation, allergy under the condition of wearing for a long time.

The application provides a mask, which comprises a mask body and an accessory for fixing the mask on a mouth and a nose, wherein the mask body comprises a textile layer, the accessory is connected with the textile layer, and a carrier layer coated with probiotics is arranged on one side of the textile layer, which is close to the mouth and the nose; the carrier layer coated with the probiotics contains a carrier coated with the probiotics; the carrier coated with the probiotics is fixed with the textile fabric layer in a sticking, embedding, adsorbing, hot-pressing or sewing mode; the carrier layer coated with probiotics is matched with the mouth-nose position in shape.

Preferably, the textile fabric layer further comprises a breathable water-absorbing layer, and the carrier layer coated with probiotics is arranged on one side of the breathable water-absorbing layer close to the mouth and nose parts.

For the adhesion of microorganisms to the surface of the material, the structure and properties of the material directly influence the adhesion effect of the microorganisms on the carrier material. Wherein, the adsorption characteristic of the carrier material is closely related to the material morphology structure, the pore distribution, the material surface chemical property and the like. The solid surface of the carrier material provides an adsorption site for adhesion of microorganisms. The material gaps not only provide growth spaces for microorganisms, are beneficial to the growth and the propagation of the microorganisms, but also are beneficial to the internal and external exchange of substances such as nutrient substances, metabolites, gases and the like. The ideal support material should have a large specific surface area and a high porosity.

Preferably, the carrier coated with the probiotics is one or more of zeolite, bentonite, kaolin, clay and activated carbon containing the probiotics.

Preferably, the textile layer is quick-drying chemical fiber, polyester fiber, non-woven fabric, gauze, sponge, cotton cloth or paper sheet.

In order to further increase the breathability, the carrier layer coated with probiotics is the minimum requirement to cover the mouth and nose, and the area is reduced. The width of the bag is 3-10cm, and the height of the bag is 2-15 cm. For example, the width is 5-10cm and the height is 5-15 cm; or 3-7cm in width and 2-5cm in height.

The probiotic bacteria are one or more of lactobacillus acidophilus, lactobacillus bulgaricus, lactobacillus paracasei, lactobacillus fermentum, lactobacillus rhamnosus, bifidobacterium bifidum and bifidobacterium longum. The probiotic bacteria of the present application may be prepared using conventional technical methods.

In the examples of the present application, the probiotic bacteria include Lactobacillus fermentum (i.e., Lactobacillus fermentum, ATCC11976) purchased from ATCC, and Streptococcus thermophilus (i.e., Streptococcus thermophilus, ATCC19258) purchased from shanghai auspicious biotechnology limited.

Preferably, the mixing ratio of lactobacillus fermentum and streptococcus thermophilus is 10: (3-10). For example, the concentration of each of the two bacteria is 3 x 10⁸cfu/ml and 2.5 x 10⁸cfu/ml, 100ml and 80ml may be mixed, respectively.

Preferably, the accessories are ear hooks which are arranged on two opposite sides of the mask body and are connected with the woven fabric layer of the mask body in a hot pressing, sewing, sticking or perforating mode; or the ear hook is derived from the textile fabric layer of the mask body and is connected with the textile fabric layer in a seamless mode.

In order to adapt to more fixing modes, the accessories comprise a plurality of rope-shaped objects, and the rope-shaped objects are connected with the mask body to fix the mask body on the mouth and nose parts.

In order to make the mask fit the face better, a metal strip can be added on one side of the upper edge of the mask close to the mouth-nose part. The metal strip is moderate in hardness and can be adjusted in shape by hand. The metal strips are preferably embedded in the textile fabric layer or wrapped by plastic and chemical fiber materials.

In order to be convenient to carry and reduce the space occupied by the mask, the mask can be compressed and folded to a volume not more than 4cm³E.g. 2cm³，3cm³Even 1cm³The following.

In order to further facilitate the use, the mask of the application is also provided with a capsule filled with water.

Preferably, the mask is compressed into a column or a cuboid, the capsule filled with water also comprises a plane, and the plane of the mask is attached to the plane of the capsule and separated by a layer of film. When the mask is used, the compression mask is pressed, breaks through the film, expands when meeting water, and is opened to cover the mouth and nose parts. Meanwhile, the probiotics are activated when meeting water, so that flora balance of the facial skin can be effectively improved.

In another aspect, the present application provides a method for preparing the mask, comprising the steps of:

preparing a textile layer and an attachment according to a predetermined shape, the attachment being connected to the textile layer;

preparing a carrier layer coated with probiotics, wherein the carrier layer coated with probiotics contains the carrier coated with probiotics; the carrier coated with the probiotics is one or more of zeolite, bentonite, kaolin, clay and activated carbon containing the probiotics;

the carrier layer coated with the probiotics is fixed with the textile layer in a sticking, inlaying, adsorbing, hot-pressing or sewing mode, the carrier layer coated with the probiotics is arranged on one side of the textile layer close to the mouth and nose parts, and the shape of the carrier layer coated with the probiotics is matched with the position of the mouth and nose parts.

Preferably, the preparation method of the carrier coated with probiotics comprises the following steps:

(1) activating and culturing probiotics, wherein the probiotics are lactobacillus fermentum and/or streptococcus thermophilus;

(2) expanding culture solution of probiotics with density of not less than 2 x 10⁸cfu/ml；

(3) Mixing the bacterial liquids to obtain a composite bacterial liquid, and controlling the ratio of lactobacillus fermentum to streptococcus thermophilus to be 10: (3-10);

(4) sterilizing the carrier, and placing the carrier in the compound bacterial liquid;

(5) and (5) freeze-dehydrating the composite bacteria liquid to obtain the carrier coated with the probiotics.

The carrier coated with the probiotics is arranged on one side of the mask close to the mouth and nose parts.

Usually, the number of effective probiotic bacteria in a mask is not less than 2 x 10⁷cfu/g。

Preferably, the preparation method further comprises the following steps:

compressing and folding the mask to a volume not exceeding 4cm³The compressed mask is provided with a plane;

preparing a water-containing capsule, wherein the water-containing capsule also comprises a plane, and the plane separates water from the outside by adopting a film;

one plane of the mask is attached to one plane of the capsule.

Preferably, the above preparation method further comprises a step of drying the mask.

The mask can be used for protecting the daily respiratory system or the digestive tract of people, can effectively reduce the phenomena of allergy, acne and the like, and is particularly suitable for people with weak immunity, such as children. The mask can be used for protecting the daily respiratory system and the digestive system of people with low immunity, daily protecting patients with skin diseases such as allergic dermatitis and the like, and performing tertiary protection on epidemic diseases such as influenza virus, coronavirus and the like.

Drawings

Fig. 1 is a schematic view showing the unfolding of an adult mask.

Wherein, 11 is the gauze mask body, 12 is the ear-hang, 13 is the carrier layer of load probiotics, 14 is the metal strip.

Fig. 2 is a schematic view of a capsule and mask.

Wherein, 21 is the capsule of dress water, 22 is the gauze mask after the compression, 23 is the space of placing compression gauze mask, 24 is the plastics spacer at capsule gauze mask top, and 25 is the film of separating gauze mask and water, and plastics spacer 24 is used for preventing that the gauze mask after the unexpected oppression of external force leads to separating the film 25 of gauze mask and water and breaks.

Fig. 3 is a schematic view of a child mask.

Wherein 31 is the children's gauze mask body, 32 is the ear-hang of children's gauze mask, and 33 is the carrier of load probiotic in the children's gauze mask.

Detailed Description

The present application will be described in more detail below. This application may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the application to those skilled in the art.

Example 1 probiotic compression mask

As shown in figure 1, the application provides a mask, including mask body and two ear-hang, the mask body include the non-woven fabrics layer, the ear-hang is connected with the non-woven fabrics layer, the non-woven fabrics layer sets up the carrier layer of coating probiotics near one side of oronasal part. The carrier layer of scribbling the probiotic contains bentonite and the cotton layer of mixing the probiotic, and the bentonite of mixing the probiotic is spread in one side of whole gauze mask oronasal part, and the cotton layer is fixed through the hot pressing mode with the non-woven fabrics layer, and the bentonite of mixing the probiotic is settled between non-woven fabrics and cotton. When in use, the mask is opened, the two ear hangers are respectively sleeved on the left ear and the right ear, and the mask is attached to the face. The upper portion that mouthful nose side is pressed close to the gauze mask is close to and goes up the position and be provided with the metal strip, uses hand strength can be stubborn wantonly for according to the crooked face that makes the gauze mask laminate more of bridge of the nose shape, better plays the guard action.

Example 2 probiotic capsule mask

As shown in fig. 2, the present application provides a compressible mask. The mask is an integrally formed ear-hanging mask when opened, and is made of quick-drying polyester fiber as main fabric, and a non-water-absorbing layer is arranged on one side close to the mouth and nose parts. A carrier loaded with probiotics is arranged between the impermeable layer and the polyester fiber, and the carrier is hot-pressed on the non-water-absorbing layer. The whole mask is compressed into a cuboid after being dried, and the appearance of the capsule filled with water is cuboid and also comprises a plane. The mask is embedded inside the water containing capsule after being compressed, a plastic sheet is arranged at the top of the mask and is arranged at the top of the water containing capsule, the bottom plane of the mask is attached to the plane of the capsule, and the mask and the capsule are separated by a layer of film. The probiotics used in the mask are composite probiotics of lactobacillus fermentum and streptococcus thermophilus, wherein the ratio of the lactobacillus fermentum to the streptococcus thermophilus is 1: 1.

when the mask is used, the package is opened, the compression mask is pressed, the mask breaks through the film, expands when meeting water, and is opened to cover the mouth and nose parts. Meanwhile, the probiotics are activated when meeting water, so that the flora balance of the facial skin can be effectively improved. When the mask is not used, the water containing capsule is slightly higher than the compressed mask, the plastic sheet is arranged at the top of the water containing capsule, and the outer package is added, so that the film between the mask and the water containing capsule is protected from being easily broken.

Example 3 probiotic mask improves face pox

To test the improvement effect of the probiotic mask on the facial skin, 100 adults were recruited to test the mask of example 1, with 20 adults wearing a daily protective mask as a control. The test time is 6 months, the temperature range is 21-34 ℃, rain exists in 23 days, wherein the rain is heavy for 3 days, and the rest is the condition of stopping when the rain is in time. The time for wearing the mask is from 8 am to eight pm, and the mask is removed in the eating time. A new mask is replaced every day. And if abnormal conditions exist, the contact persons of the test group are informed in time. Determining whether to change masks with different probiotic formulas in a week unit.

The mask of example 1 was worn by all of the test subjects except 20 volunteers wearing a daily mask for the first week, using lactobacillus fermentum as probiotic. By the evening of day 7, 13 of 20 control group members had the phenomenon of closed pox, and 23 of 80 experimental group members had the phenomenon of long pox or red rash. Therefore, the mask is additionally provided with the carrier layer loaded with probiotics, and the health condition of the facial skin of a wearer is obviously improved.

In the second week, 4 persons exited the test. 20 volunteers wearing the daily mask are taken as a control group, the rest testers are divided into 4 groups, each group has 19 people, and the number ratio of lactobacillus fermentum to streptococcus thermophilus worn in the mask is respectively 1: 0.5,1: 1, 1: 2,1: 3. in the evening of day 7, 12 of 20 control group members had acne, and 2, 5, 4 and 6 of 4 experimental group members had acne or erythra. It can be seen that increasing the proportion of lactobacillus fermentum is more beneficial for maintaining facial health.

In the third week, 20 daily masks were worn, and the remaining subjects were divided into 4 groups, wherein the mask was worn with lactobacillus fermentum and streptococcus thermophilus in a number ratio of 1: 0.3,1: 0.5,1: 0.8,1: 1. in the evening of day 7, 11 of 20 control group members had the phenomenon of acne oppression, and 3, 2 and 3 of 4 experimental group members had the phenomenon of acne growth or erythema.

All around, 20 testers wear daily gauze mask, and other testers divide into 4 groups, and the quantity proportion of using fermented lactobacillus and streptococcus thermophilus in wearing the gauze mask is 1: 0.3,1: 0.5,1: 0.8,1: 1, but directly attaching probiotic freeze-dried powder on the non-woven fabric, and not containing bentonite. In the evening of day 7, 13 of 20 control group members had the phenomenon of acne oppression, and 5, 4, 5 and 5 of 4 experimental group members had the phenomenon of acne growth or erythema.

Generally, the mask containing the probiotic carrier layer can be worn to effectively promote the health of facial skin.

Example 4 probiotic capsule mask for children

The difference between the children probiotic capsule mask and the adult mask of example 2 is that the carrier layer coated with probiotics is small, and is set to be pear-shaped according to the shape of the mouth and nose of the children, the widest part is 7cm, the narrower part is 3cm, and the height is 5 cm. The probiotics used in the mask are composite probiotics of lactobacillus fermentum and streptococcus thermophilus, wherein the ratio of the lactobacillus fermentum to the streptococcus thermophilus is 1: 1. except that the textile fabric of the mask uses different colors, the outer side of the mask is printed with colorful patterns and cartoon images so as to increase the attention of children to the mask. The mask is designed in an integrated manner and is convenient to wear.

During probation, partial parents reflect, because gauze mask outward appearance is ordinary, but press the back and meet water inflation, grow out a beautiful gauze mask, improved the wish that children wear this gauze mask before the school age greatly, played the effect of protection.

Example 5 probiotic mask conditions to reduce child eruption

The effect of a total of 14 test masks was collected for 4-6 years old children.

Wear ordinary gauze mask and this application gauze mask 7 each. The wearing time is 3 days, the wearing time period is 8 to 11 am every day, 14 to 18 pm every day, and a new mask is used every day. Daily behaviors such as eating and drinking are not limited.

The child who wore the ordinary mask group left the experimental group on day 2 and day 3 because he did not want to wear the mask. The children wearing the mask of the present application also had one who did not continue the test on day 3. Statistics is carried out after 3 days, and results show that 3 children wearing the common mask have discomfort, wherein two children wear the common mask and have red plaques or small rashes around the mouth, and no one child wearing the probiotic mask has face skin itch, red swelling and rashes.

The above-mentioned experiment shows that the gauze mask of this application is more fit for children and wears, can show the probability that reduces facial discomfort or allergy moreover.

As those skilled in the art will appreciate, the present application may be embodied in many other specific forms without departing from the spirit or scope thereof. Although embodiments of the present application have been described, it is to be understood that the present application is not limited to those precise embodiments, and that various changes and modifications may be effected therein by one skilled in the art within the spirit and scope of the present application as defined by the appended claims. For example, the probiotic capsule mask of embodiment 2 is not only portable, but also convenient to use, and the probiotic is activated when meeting water, can better play a protective role. The mask of example 1 may also be modified in size for children, etc., and such modifications are within the scope of the present application.

Claims

1. A mask with protection function comprises a mask body and an accessory for fixing the mask body on a mouth and a nose, wherein the mask body comprises a textile layer, and the accessory is connected with the textile layer;

the carrier layer coated with the probiotics contains a carrier coated with the probiotics;

the carrier coated with the probiotics is one or more of zeolite, bentonite, kaolin, clay and activated carbon containing the probiotics, and is fixed with the textile fabric layer in a sticking, inlaying, adsorbing, hot-pressing or sewing mode;

the shape of the carrier layer coated with probiotics matches the position of the mouth and nose.

2. The mask of claim 1 wherein said textile layer is quick-drying chemical fiber, polyester fiber, non-woven fabric, gauze, sponge, cotton cloth, or paper sheet.

3. The mask of claim 1 wherein said probiotic coated carrier layer has a width of 5-10cm and a height of 5-15 cm; or 3-7cm in width and 2-5cm in height.

4. The mask of claim 1 wherein said probiotic bacteria are lactobacillus fermentum and streptococcus thermophilus in a ratio of 10: (3-10).

5. The mask of any one of claims 1 to 4 wherein said mask is compressed and folded to a volume of no more than 4cm³And is accompanied by a capsule containing water.

6. The mask of claim 5 wherein said mask is compressed into a column or cuboid and said water containing capsule comprises a flat surface, said flat surface of said mask being attached to said flat surface of said capsule and separated therefrom by a membrane.

7. The method of making a mask of claim 1 wherein said method of making comprises the steps of:

8. The method according to claim 7,

the preparation method of the carrier coated with the probiotics comprises the following steps:

9. The method of making a mask of claim 7 further comprising the steps of:

one plane of the mask is attached to one plane of the capsule.

10. The use of a mask according to claim 1, wherein said mask is used for daily respiratory and digestive protection, respiratory and digestive protection for immunocompromised patients, daily protection for atopic dermatitis, or tertiary protection for epidemic diseases.