CN112006670A - Control system for composite venous catheter and real-time monitoring of central venous pressure - Google Patents
Control system for composite venous catheter and real-time monitoring of central venous pressure Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
- A61B5/02152—Measuring pressure in heart or blood vessels by means inserted into the body specially adapted for venous pressure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0247—Pressure sensors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
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Abstract
The application relates to the technical field of medical instruments, in particular to a control system for a composite venous catheter and a real-time monitoring central venous pressure. The composite intravenous catheter comprises: a peripheral lumen; a central lumen located in the inner space of the peripheral lumen, the central lumen being configured to receive a pressure sensor and a line for conducting a signal of the pressure sensor, the pressure sensor being located at the implanted end of the compound venous catheter; at least one diaphragm is arranged between the central lumen and the peripheral lumen; the at least one diaphragm is connected to the outer side wall of the central lumen on one side and the inner side wall of the peripheral lumen on the other side so as to form at least two channels between the outer side wall of the central lumen and the inner side wall of the peripheral lumen, and the channels in the at least two channels are independent of each other. The catheter is safe, reliable, long in service life, good in biocompatibility, capable of being processed in batches, and direct and accurate in real-time measurement.
Description
Technical Field
The application relates to the technical field of medical instruments, in particular to a control system for a composite venous catheter and a real-time monitoring central venous pressure.
Background
The laparoscopic liver resection has attracted attention due to the advantages of light surgical wound, quick postoperative recovery and the like, and the laparoscopic liver resection is widely developed and the surgical indications are continuously widened along with the development of laparoscopic technology and the improvement of surgical instruments at present. The bleeding during the operation which is difficult to control is the most common factor for opening the abdomen in the laparoscopic hepatectomy, therefore, the effective prevention of the bleeding during the operation and the timely and effective control of the bleeding are the key points for the smooth implementation of the laparoscopic hepatectomy, and the prevention of the bleeding during the operation is more important.
The low central venous pressure technology is a key technology for preventing intraoperative hemorrhage, but how to accurately monitor the central venous pressure in real time is a difficulty. The currently used method of detecting central venous pressure is to use a transducer for the conversion, because the conventional transducers are too bulky to be connected to remote test equipment by a long wire, i.e. far from the venous pressure measurement site, and cannot be directly tested in situ. The remote test is interfered by the experience of the anaesthetist, the body position of the operation patient, the pressure of the peritoneoscope pneumoperitoneum and other factors, and the accuracy needs to be enhanced. In order to perform laparoscopic liver resection more safely, a real-time and accurate device for monitoring the central venous pressure is urgently needed in the clinical work of laparoscopic liver resection.
Disclosure of Invention
At present, no equipment for monitoring central venous pressure in real time and accurately is urgently needed in the clinical work of laparoscopic liver resection because of the following technical problems: the micro pressure sensor chip which meets the volume requirement in the industry and is based on optical fiber transmission has the problems that the sensor is easy to damage and the measurement range is not suitable due to the processing technology of the micro pressure sensor chip, and the micro pressure sensor chip can not be directly applied to central venous pressure measurement. The measurement range is usually 6-42 cm H2O, i.e. cannot cover 0-5 cm H2O range, (and 0-5 cm H)2The O pressure range is very important, especially close to 0 cmH2O, is a danger monitoring area. ) I.e. cannot cover the measurement range of 0-15 cmH required for low central venous pressures2O。
The application provides a composite catheter suitable for in-situ measurement of central venous pressure and a processing technology thereof. The sensor offset can be adjusted manually and randomly, and the problem of range mismatch in the production process is solved. Meanwhile, the method has good biocompatibility, the improvement of the biocompatibility and the assembly of the sensor are completed synchronously, the performance is improved, and the production cost is saved. In conclusion, the catheter can detect the central venous pressure by utilizing the miniature pressure sensor chip attached to the tip of the optical fiber, so that the in-situ pressure detection can be carried out; the offset of the sensors on the market can be adjusted by the adjustable offset structural design to reach the range required by central venous pressure measurement. The scheme of the embodiment of the application has the advantages of safety, reliability, long service life, good biocompatibility, batch processing and direct and accurate real-time measurement. Because the intervention human body part is in a passive period, the development and development design related to electromagnetic compatibility safety is not involved, and the method has the advantages of simple approval relative to the active pressure sensor and quick marketing.
In a first aspect, embodiments of the present application provide a composite intravenous catheter, comprising: a peripheral lumen; a central lumen located in the inner space of the peripheral lumen, the central lumen being configured to receive a pressure sensor and a line for conducting a signal of the pressure sensor, the pressure sensor being located at the implanted end of the compound venous catheter; at least one diaphragm is arranged between the central lumen and the peripheral lumen; the at least one diaphragm is connected to the outer side wall of the central lumen on one side and the inner side wall of the peripheral lumen on the other side so as to form at least two channels between the outer side wall of the central lumen and the inner side wall of the peripheral lumen, and the channels in the at least two channels are independent from each other; wherein, in the use state of the composite venous catheter, the implantation end is used for implanting into a vein of a subject, and the pressure sensor is used for detecting the vein pressure; the at least two channels are used for conveying liquid medicine.
In some embodiments, the pressure sensor is a fiber optic pressure sensor, and the circuitry for conducting the pressure sensor signal is a signal conducting fiber of the fiber optic pressure sensor; under the non-use state of compound venous catheter, the contained angle between first diaphragm and the first tangent line is not 90 degrees, first diaphragm is any diaphragm in at least one diaphragm, first tangent line is first diaphragm with the tangent line of the lateral wall junction of central lumen.
In some embodiments, in a non-use state of the composite intravenous catheter, an included angle between the first diaphragm and the first tangent is 30 degrees to 60 degrees, or an included angle between the first diaphragm and the first tangent is 120 degrees to 150 degrees.
In some embodiments, the pressure sensor is or includes a silicon sensor chip.
In some embodiments, the pressure sensor has a primary sensing surface that is raised by the hydrogel.
In some embodiments, a sensor packaging sensing surface is further arranged on the outer side of the original sensing surface of the sensor, the sensor packaging sensing surface is formed by coating a film on medical Parylene series materials, and the thickness of the sensor packaging sensing surface is 1-10 mu m.
In some embodiments, the at least one diaphragm is 3 diaphragms evenly distributed between the central lumen and the peripheral lumen, and the at least two channels are 4 channels evenly distributed between the central lumen and the peripheral lumen.
In some embodiments, a first channel has a plurality of outlets at the implantation end, the first channel being any one of the at least two channels.
In a second aspect, an embodiment of the present application provides a control system for monitoring central venous pressure in real time, including the composite venous catheter of the first aspect, an infusion pump, and an interferometric pressure detector; wherein an insertion end of a composite intravenous catheter is inserted into the infusion pump port, and a line in the composite intravenous catheter for conducting the pressure sensor signal is connected to the interferometric pressure probe.
In some embodiments, the infusion pump is a servo motor controlled peristaltic pump.
The scheme provided by the embodiment of the application has the following scheme.
1. The pressure detector is small in size, pressure can be detected and various liquid medicines can be supplied simultaneously only by minimally invasive insertion of blood vessels once, and compared with the traditional method, the frequency of wounds can be reduced. Can independent control multichannel liquid medicine independently import, overcome traditional intravenous catheter injection medicine, when need inject into former medicine injection at the remaining problem of intracavity, improve dosage control degree of accuracy. The system can realize closed-loop measurement and automatically control the central vein to be pressed in a safe interval, so that an operating doctor can concentrate on the minimally invasive surgery.
2. When the preparation before laparoscopic hepatectomy is performed, a central venous catheter is conventionally placed into an anaesthetist, and the application of the composite venous catheter can play a role of killing two birds with one stone, so that the infusion can be quickly performed, and the central venous pressure can be monitored in real time. The wound is reduced, and the stability of the pressure sensor is improved.
3. The composite venous catheter provided by the embodiment of the application utilizes the silicon sensor chip attached to the tip of the optical fiber to detect the central venous pressure, has direct, accurate and real-time effects, and avoids factors such as the experience of an anaesthetist, the body position of a surgical patient, the pressure of the pneumoperitoneum of a laparoscope and the like. In particular, a micro pressure guide channel for measuring pressure on the side surface is designed, so that the pressure of the central vein can be detected by storing the sensitive surface of the sensor in the composite tube, and the sensitive surface of the sensor is prevented from being damaged.
4. The scheme that this application embodiment provided has and bends protection effect to optic fibre pressure sensor for optic fibre pressure sensor bending stability improves.
5. The embodiment of the application provides a packaging design and a processing technology of a sensing surface of a sensor. The process combines a specific fine adjustment structure of the rechecking tube, has the implementation effect that the range of the sensor can be adjusted by increasing or reducing the offset while protecting the sensor from physical and chemical damage, so that the process is suitable for measuring the central venous pressure in the operation.
Drawings
FIG. 1 is a perspective view of a composite intravenous catheter provided in accordance with an embodiment of the present application;
FIG. 2 is a cross-sectional view of a composite intravenous catheter provided in accordance with an embodiment of the present application;
FIG. 3 is a cross-sectional view of a composite intravenous catheter provided in accordance with an embodiment of the present application in a bent state;
FIG. 4 is a schematic structural diagram of a sensor module in a composite intravenous catheter provided in an embodiment of the present application;
fig. 5 is a schematic structural diagram of a pressure sensor in a composite intravenous catheter according to an embodiment of the present application.
Detailed Description
The following examples are merely illustrative of the present application and should not be construed as limiting the scope of the present application. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
Before the present embodiments are further described, it is to be understood that the scope of the present application is not limited to the particular embodiments described below; it is also to be understood that the terminology used in the examples herein is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present application; in the specification and claims of this application, the singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise.
When numerical ranges are given in the examples, it is understood that both endpoints of each of the numerical ranges and any value therebetween can be selected from the group consisting of the endpoints unless otherwise indicated herein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In addition to the specific methods, devices, and materials used in the examples, any methods, devices, and materials similar or equivalent to those described in the examples may be used in the practice of the present application, in addition to the specific methods, devices, and materials used in the examples, in keeping with the knowledge of one skilled in the art and the description of the present application.
The embodiment of the application provides a control system of compound venous catheter and real-time supervision central venous pressure, when the operation in-process is amputated to peritoneoscope liver, real-time, accurate monitoring central venous pressure lets peritoneoscope liver resection operation safer. The pressure detector is small in size, and can detect pressure and supply various liquid medicines simultaneously only by one-time minimally invasive operation, so that the wound times are reduced. Can independent control multichannel liquid medicine independently import, overcome traditional intravenous catheter injection medicine, when need inject into former medicine injection at the remaining problem of intracavity, improve dosage control degree of accuracy. The system can realize closed-loop measurement and automatically control the central vein to be pressed in a safe interval, so that an operating doctor can concentrate on the minimally invasive surgery.
In some embodiments, the composite venous catheter has a front-end pressure measurement function, and has functions of multi-channel infusion tube, pressure measurement, drug administration and closed-loop control of central venous pressure. The composite venous catheter has the advantages of being good in robustness, accurate in measurement and small in size, reducing trauma and simplifying operation steps due to implementation effect, and the composite venous catheter structure comprises a central lumen and a peripheral lumen, wherein the wall of the peripheral lumen is inclined relative to the axial direction. The central tube cavity is used for storing the optical fiber pressure sensor and the signal transmission optical fiber thereof. The peripheral tube cavity is used for conducting liquid medicine and plays a role in isolating, buffering and protecting the optical fiber pressure sensor. The following advantages are also provided: since the peripheral lumen wall is inclined with respect to the axial direction, a greater range of motion of the fiber optic pressure sensor is allowed to relieve bending pressures. Meanwhile, a plurality of transfusion channels exist in the peripheral tube cavity, so that a plurality of kinds of liquid medicines are allowed to be independently input and controlled; the composite venous catheter has the advantages that each cavity of the peripheral lumen is provided with a plurality of outlets, so that thrombus blockage can be prevented, medical risks can be reduced, a continuous or pulse type administration mode is supported, the pulse type can clean the thrombus blockage liquid outlet, the medical risks can be reduced, the biocompatibility of the composite venous catheter is good, the offset can be corrected, the tip protection structure of the sensor and the processing technology of the tip protection structure can solve the problem that the existing silicon pressure sensor in the market can not be applied to central venous pressure measurement.
Next, the scheme of the embodiment of the present application will be specifically described with reference to fig. 1 to 5.
As shown in fig. 1, the present embodiment provides a composite intravenous catheter 1, including: a peripheral lumen; a central lumen located in the inner space of the peripheral lumen, the central lumen being configured to receive a pressure sensor and a line for conducting a signal of the pressure sensor, the pressure sensor being located at the implanted end of the compound venous catheter; at least one diaphragm is arranged between the central lumen and the peripheral lumen; the at least one diaphragm is connected to the outer side wall of the central lumen on one side and the inner side wall of the peripheral lumen on the other side so as to form at least two channels between the outer side wall of the central lumen and the inner side wall of the peripheral lumen, and the channels in the at least two channels are independent from each other; wherein, in the use state of the composite venous catheter, the implantation end is used for implanting into a vein of a subject, and the pressure sensor is used for detecting the vein pressure; the at least two channels are used for conveying liquid medicine.
The central lumen may be the sensing channel 11 shown in fig. 1, with the exit of the sensing channel 11 at the implantation end being the sensing channel exit 111. The channel of the at least two channels may be an infusion channel 12 as shown in fig. 1, the outlet of the infusion channel 12 at the implanted end being an infusion channel outlet 121. The pressure sensor and the lines for conducting the pressure sensor signal belong to the sensor module 2 in fig. 1.
The peripheral lumen, the central lumen and the diaphragm in the composite venous catheter 1 can be made of special medical materials, such as fluoroplastic, PU and the like, and are suitable for porous extrusion forming process.
In some embodiments, the pressure sensor is a fiber optic pressure sensor, and the circuitry for conducting the pressure sensor signal is a signal conducting fiber of the fiber optic pressure sensor; under the non-use state of compound venous catheter, the contained angle between first diaphragm and the first tangent line is not 90 degrees, first diaphragm is any diaphragm in at least one diaphragm, first tangent line is first diaphragm with the tangent line of the lateral wall junction of central lumen. The signal conducting fiber may be the sensor conducting fiber 23 as shown in fig. 4.
As can be seen in fig. 2 and 3, the diaphragm between the central lumen and the outer sidewall and the inner sidewall of the peripheral lumen is angled with respect to the axial direction of the central lumen so that when the composite intravenous catheter is bent, the optical fiber is free to move in multiple directions within the interior of the composite intravenous catheter to reduce the bend radius.
In some embodiments, in a non-use state of the composite intravenous catheter, an included angle between the first diaphragm and the first tangent is 30 degrees to 60 degrees, or an included angle between the first diaphragm and the first tangent is 120 degrees to 150 degrees.
Through controlling the inclined angle of the diaphragm relative to the central lumen, when the composite venous catheter is bent, the optical fiber can freely move in multiple directions in the composite venous catheter, so that the bending radius is reduced.
In some embodiments, the pressure sensor is or includes a silicon sensor chip.
In some embodiments, referring to fig. 4 and 5, the pressure sensor has a primary sensor surface 21, and the primary sensor surface 21 is in a convex state under the influence of the hydrogel. The primary sensing surface 21 of the sensor is provided with a first layer of protective material which is in a convex state as shown in fig. 4 under the influence of the hydrogel 24 of the sensor package. The sensor package hydrogel 24 may be a low durometer PDMS material.
In some embodiments, a sensor packaging sensing surface 22 is further arranged on the outer side of the original sensing surface of the sensor, the sensor packaging sensing surface 22 is formed by coating medical Parylene series materials, and the thickness of the sensor packaging sensing surface 22 is 1-10 μm. The sensor package sensing surface 22 is made of medical Parylene series material, such as Parylene-C, Parylene-N, Parylene-D. The sensor package sensing surface 22 may be fabricated by a Parylene CVD coating process.
In some embodiments, the at least one diaphragm is 3 diaphragms evenly distributed between the central lumen and the peripheral lumen, and the at least two channels are 4 channels evenly distributed between the central lumen and the peripheral lumen. The existence of a plurality of transfusion channels can allow a plurality of medical liquids to be independently input and controlled.
In some embodiments, a first channel has a plurality of outlets at the implantation end, the first channel being any one of the at least two channels. Each infusion channel is provided with a plurality of outlets, so that thrombus blockage can be prevented, and medical risks can be reduced.
The embodiment of the application also discloses a control system for monitoring the central venous pressure in real time, which comprises a composite venous catheter 1, an infusion pump (not shown) and an interference pressure detector (not shown); wherein the insertion end of the composite intravenous catheter 1 is inserted into the infusion pump port and the lines in the composite intravenous catheter 1 for conducting the pressure sensor signal are connected to the interferometric pressure probe.
In some embodiments, the infusion pump is a servo motor controlled peristaltic pump.
Next, the use of the compound intravenous catheter and control system is described.
The insertion end of the composite intravenous catheter is first connected to the infusion pump port and the optical fiber is connected to the interferometric pressure probe. And calibrating the zero point, and inputting the liquid medicine into the infusion pump. The expected central venous pressure range is set, and the automatic pressure control function can be started after the composite tube is implanted into a proper position.
The optical fiber protection principle is as follows: due to the fine diameter of the composite tube, the inner space needs to be reserved for conveying the liquid medicine as far as possible, because of the surface tension of the liquid medicine, strong pressure is needed to convey the liquid medicine, the dosage is difficult to control, and the design of the rear-end administration device is difficult early. The fiber cannot be protected in the conventional manner by adding a jacket, i.e., the fiber is no longer in the neutral zone when bent. The inventive structure allows the optical fiber to move freely in multiple directions inside the composite tube to reduce the bend radius. As shown in fig. 2 and 3, when the composite tube is bent, the optical fiber is biased to one side to reduce the bending stress.
The manufacturing and assembly process of the composite intravenous catheter 1 is as follows.
The assembly process of the sensor module 2 comprises the following steps:
first, a pulling sleeve (not shown) is fitted over the sensor module 2.
The pull cannula is then passed through the sensing channel 11 of the composite intravenous catheter 1 and, due to its relatively stiff and thin nature, may more easily enter the sensing channel 11 and exit the sensing channel exit port 111).
Next, the sensor module 2 is pulled through the sensing channel 11 by the pulling sleeve and the sensor package sensing face 22 is brought to the position of the access port inside the sensing channel exit 111.
Finally, the pulling sleeve 3 is pulled further away from the sensor channel 11.
Thereby, the composite intravenous catheter 1 shown in fig. 1 can be obtained.
Next, a sensor module 2 packaging process is described.
The sensor module 2 is slowly withdrawn from the composite intravenous catheter 1 to achieve separation.
Next, the packaging process (to be embodied) of the original sensing surface 21 of the sensor will be described.
First, the original sensing surface 21 of the sensor can be added with a proper amount of PDMS hydrogel by using a dispenser. And (4) preserving the hydrogel in vacuum at normal temperature, and keeping the original sensing surface 21 of the sensor vertically downwards to form a bulge until the hydrogel is solidified. If the hydrogel does not bulge, the procedure can be repeated again. Secondly, the sensor module 2 with the sensor packaging sensing surface 22 is subjected to a Parylene CVD coating process. The thickness of the plated film is 1-10 mu m, and the sensitivity of the sensor is preferably not influenced.
The sensor primary sensing face 21 and the sensor conducting fiber 23 may be commercially available, and may be purchased as one piece. The maximum outer diameters of the sensor primary sensing surface 21 and the sensor conducting fiber 23 do not exceed 0.25 mm.
The sensor module 2 has a package structure as shown in fig. 4, including: a sensor original sensing surface 21, a sensor packaging sensing surface 22, a sensor conducting optical fiber 23 and sensor packaging hydrogel 24. The original sensing surface 21 of the sensor is connected with sensor packaging hydrogel 2.4, the sensor packaging hydrogel 24 is connected with the sensor packaging sensing surface 22, and the sensor packaging sensing surface 22 is connected with the sensor conducting optical fiber 23. The sensor conducting fiber 2.3 is connected with the back end test system.
Next, the sensor offset amount adjustment step is described.
The diameter of the central lumen port is enlarged by a cavity enlarging cone and a cone tip port is formed. The optical fiber pressure sensor optical fiber is inserted into the composite tube from the conical tip port through a traction guide wire, and the optical fiber is introduced into and passes through the central cavity of the composite tube by pulling the traction guide wire. The traction guide wire is removed, and the optical fiber is connected to the interference type pressure detector. At standard atmospheric pressure, the pressure sensor is brought into the cone by pulling the fiber, the fiber is pulled further and the pressure reading is observed when the reading is at a suitable offset, e.g. 10 cm H2And when O is needed, stopping traction, fixing the optical fiber, the sensor and the composite tube cavity by using medical epoxy glue, and observing pressure bias.
Next, the administration mode will be described.
The peristaltic pump is controlled by a private motor, and the peristaltic pump extrudes the liquid storage chamber. Wherein, in the continuous administration state, the peristaltic pump is driven by a constant torque mode; in the pulse type administration state, the peristaltic pump is driven in a constant speed mode.
In the embodiment of the application, the central venous pressure is accurately monitored in real time during the laparoscopic liver resection operation by using the composite venous catheter for monitoring the central venous pressure in real time. The composite venous catheter has the characteristics of stable performance, small volume, simultaneous administration and pressure measurement and small wound. In the described technology, a multiplexing transfusion channel is used as a pressure measuring sensor and a protection channel of a conduction optical fiber thereof; on the other hand, the packaging mode of the sensor provided by the invention not only protects the sensor and meets the biocompatibility requirement of contacting blood for a short time; thirdly, the proposed packaging mode is combined with the special structure of the composite pipe, so that the offset of the pressure sensor can be adjusted and is not influenced by the processing technology.
The application has the advantages that the laparoscopic liver resection operation can be safer, bleeding in the operation is reduced, and the recovery of a patient is improved.
The above-mentioned embodiments, objects, technical solutions and advantages of the present application are described in further detail, it should be understood that the above-mentioned embodiments are merely exemplary embodiments of the present application, and are not intended to limit the scope of the present application, and any modifications, equivalent substitutions, improvements and the like made within the spirit and principle of the present application should be included in the scope of the present application.
Claims (10)
1. A composite intravenous catheter, comprising:
a peripheral lumen;
a central lumen located in the inner space of the peripheral lumen, the central lumen being configured to receive a pressure sensor and a line for conducting a signal of the pressure sensor, the pressure sensor being located at the implanted end of the compound venous catheter;
at least one diaphragm is arranged between the central lumen and the peripheral lumen; the at least one diaphragm is connected to the outer side wall of the central lumen on one side and the inner side wall of the peripheral lumen on the other side so as to form at least two channels between the outer side wall of the central lumen and the inner side wall of the peripheral lumen, and the channels in the at least two channels are independent from each other;
wherein, in the use state of the composite venous catheter, the implantation end is used for implanting into a vein of a subject, and the pressure sensor is used for detecting the vein pressure; the at least two channels are used for conveying liquid medicine.
2. The composite intravenous catheter of claim 1, wherein said pressure sensor is a fiber optic pressure sensor, and said circuitry for conducting said pressure sensor signal is a signal conducting fiber of said fiber optic pressure sensor;
under the non-use state of compound venous catheter, the contained angle between first diaphragm and the first tangent line is not 90 degrees, first diaphragm is any diaphragm in at least one diaphragm, first tangent line is first diaphragm with the tangent line of the lateral wall junction of central lumen.
3. The composite intravenous catheter of claim 2, wherein in a non-use state of the composite intravenous catheter, an angle between the first diaphragm and the first tangent is between 30 degrees and 60 degrees, or an angle between the first diaphragm and the first tangent is between 120 degrees and 150 degrees.
4. The composite intravenous catheter of claim 2, wherein said pressure sensor is or comprises a silicon sensor chip.
5. The composite intravenous catheter of claim 2 wherein said pressure sensor has a sensor primary sensing surface that is raised by the hydrogel.
6. The composite intravenous catheter of claim 5, characterized in that a sensor packaging sensing surface is further arranged on the outer side of the original sensing surface of the sensor, the sensor packaging sensing surface is formed by coating a film on medical Parylene series materials, and the thickness of the sensor packaging sensing surface is 1-10 μm.
7. The composite intravenous catheter of claim 1, wherein said at least one diaphragm is 3 diaphragms evenly distributed between said central lumen and said peripheral lumen, and said at least two channels are 4 channels evenly distributed between said central lumen and said peripheral lumen.
8. The compound intravenous catheter of claim 1, wherein a first channel has a plurality of outlets at the implanted end, the first channel being any one of the at least two channels.
9. A control system for real-time monitoring of central venous pressure, comprising a compound intravenous catheter of any of claims 1-8, an infusion pump and an interferometric pressure probe; wherein an insertion end of a composite intravenous catheter is inserted into the infusion pump port, and a line in the composite intravenous catheter for conducting the pressure sensor signal is connected to the interferometric pressure probe.
10. The control system of claim 9, wherein the infusion pump is a servo motor controlled peristaltic pump.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114034428A (en) * | 2022-01-10 | 2022-02-11 | 杭州未名信科科技有限公司 | Packaging structure and measuring catheter |
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