CN1119929C - Pig embryo regulation factor and its preparing process and application - Google Patents
Pig embryo regulation factor and its preparing process and application Download PDFInfo
- Publication number
- CN1119929C CN1119929C CN 00112089 CN00112089A CN1119929C CN 1119929 C CN1119929 C CN 1119929C CN 00112089 CN00112089 CN 00112089 CN 00112089 A CN00112089 A CN 00112089A CN 1119929 C CN1119929 C CN 1119929C
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- sow
- present
- regulation factor
- glucose
- pig
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention discloses a regulation factor of a pig embryo. 1% to 2% of dextrose is added into distilled water to be uniformly solubilized, mixed, and is cooled to about 40 DEG C after heated to boil, 0.02% to 0.04% of sulfuric acid estrogen is added, and the present invention is manufactured by being loaded respectively after solubilization and mix. After a sow is mated for 11 to 14 days, the present invention is injected into a reproductive system of the sow in the dose of 1 to 2 milliliters per sow. The present invention can artificially increase the gestation recognition of the sow, and thereby, the reproduction potential of the sow is regulated. The death rate of early embryos is reduced, and finally, the goals of increasing the number born of each litter of the sow and improving the economic benefits of breeding sows are achieved. The practicability of the present invention is strong, which can be easily seen. The present invention accords with China's national conditions, and huge social benefits and economic benefits are generated after popularization and application.
Description
Technical field
The present invention relates to a kind of embryo regulation factor that helps to increase the every tire litter size of sow, and the methods for making and using same of this embryo regulation factor, domestic animal reproductive technology field belonged to.
Background technology
China is the biggest in the world tame pig producing country, and 400,000,000 bull live pigs are arranged, and wherein sow is more than 2,000 ten thousand.How not increase the pig house building and to have now under the situation of raising condition, and every tire litter size of increase sow has become the important topic that enlarges the feeding live pig scale and benefit.
Studies show that there are three periods of comparatively concentrating on the peak of sow offspring loss, i.e. fertilization and body early embryo loss phase, animal birth initial stage, preadolescence.At present, both at home and abroad all obtaining gratifying results aspect the regulation and control of oestrus of sow phase number of eggs ovulated and the Farrowing control, yet early stage death control for the embryo, especially aspect the conceived identification of increase, minimizing body early embryo lethality, according to the retrieval of applicant, still there is not the result of study of application so far to interrelated datas such as CAB databases.
Summary of the invention
The objective of the invention is to: propose a kind of pig embryo regulation factor that can transfer sow breeding potential quality, increase the every tire litter size of sow, the present invention simultaneously also will provide the methods for making and using same of this pig embryo regulation factor, thereby do not increasing the pig house building, do not changing under the situation of existing raising condition, improve the economic benefit of tame swine rearing, can provide a kind of pharmaceutical preparations for animal drug factory simultaneously.
To achieve these goals, pig embryo regulation factor of the present invention is mixed by following component:
Sulfuric acid oestrogenic hormone 0.02%--0.04%
All the other are distilled water for glucose 1%--2%.
More than non-water component very few, be difficult to reach and increase young effect, and too much will cause the injection portion inflammation, same influence increases young effect.
Pig embryo regulation factor of the present invention prepares in accordance with the following methods:
A. glucose is added in the distilled water and evenly mix;
B. make the heating of glucose dissolving mixed liquor, until boiling;
C. the glucose mixed liquor after will seething with excitement is cooled to about 40 ℃;
D. add sulfuric acid oestrogenic hormone;
E. dissolving mixes the back sub-bottle packaging.
The application in accordance with the following methods of pig embryo regulation factor of the present invention: behind insemination of sows 11-14 days, be expelled to the sow genital system with the dosage of every pig 1-2 milliliter.Too early or cross slow injection and all be difficult to the effect that reaches desirable.
According to the theriogenology theory, the appearance that conceived identification is conceptus (Conceptus) is postponed the degeneration of corpus luteum, continues synthetic justacrine progestational hormone, thereby makes pregnancy be established and keep down.Studies show that, the special character of the conceived recognition mechanism of pig is that blastaea begins elongation rapidly at after fertilization about 12 days, the oestrogenic hormone of its secretion can make the synthetic luteolysis material of endometrium reduce, thereby makes unlikely being affected of corpus luteum and degenerate, and pregnancy is promptly kept down.According to method of the present invention, after pig embryo regulation factor of the present invention being injected the genital system of pig, can increase the pregnancy identification of pig artificially, thereby transfer sow breeding potential quality, reduce the body early embryo lethality, finally reach the purpose that increases the every tire litter size of sow, improves tame swine rearing economic benefit.Be not difficult to find out that the present invention is practical, tally with the national condition, will have a tremendous social and economic benefits after applying.
Embodiment
Below in conjunction with embodiment the present invention is described in further detail.
Embodiment one
The pig embryo regulation factor of present embodiment is mixed and made into each component according to the following steps:
A. 50 gram glucose are added in 5000 ml distilled waters and evenly mix (be equivalent to glucose and account for 1%);
B. treat glucose dissolving back heating, until boiling;
C. the glucose mixed liquor after will seething with excitement is cooled to 40 ℃;
D. add 1 gram beta estradiol 3-sulphate (β-Estradial 3-sulfate) sulfuric acid oestrogenic hormone again, its molecular formula is: C
18H
23OSN
a, structural formula is: 1.3.5[10]-Estratriene-3,17-β-diol, the β of 3sulfate-Estradial 3-sulfate sulfuric acid oestrogenic hormone (be equivalent to sulfuric acid oestrogenic hormone and account for 0.02%); E. dissolving mixes the back sub-bottle packaging.
The present embodiment pig embryo regulation factor is used in accordance with the following methods: behind insemination of sows 12 days, be expelled to by the vaginal orifice of sow with the dosage of 2 milliliters of every pigs.Experiment showed, to be injected at other absorption and the protection embryo who more helps the pig body of vaginal orifice, therefore, can reach the desirable young purpose that increases than being expelled to the better effects if that intrauterine etc. is located.A large amount of result of the tests of doing according to present embodiment increased young 1.34 for average every sow every year, and this achievement has been passed through the evaluation of the Shandong Province State Scientific and Technological Commission on November 27th, 1999.
Embodiment two
The pig embryo regulation factor of present embodiment is mixed and made into each component according to the following steps:
A. 100 gram glucose are added in 5000 ml distilled waters and evenly mix (be equivalent to glucose and account for 2%);
B. treat glucose dissolving back heating, until boiling;
C. the glucose mixed liquor after will seething with excitement is cooled to 40 ℃;
D. adding 2 gram molecule formulas again is: C
18H
23OSN
a, structural formula is: 1.3.5[10]-Estratriene-3,17-β-di ol, the β of 3sulfate-Estradial 3-sulfate sulfuric acid oestrogenic hormone (be equivalent to sulfuric acid oestrogenic hormone and account for 0.02%);
E. dissolving mixes the back sub-bottle packaging.
The application in accordance with the following methods of present embodiment pig embryo regulation factor: behind insemination of sows 14 days, be expelled to by the vaginal orifice of sow with the dosage of 1 milliliter of every pig.Experiment showed, that such enforcement the present invention also can reach the comparatively desirable young effect that increases.
Claims (3)
1. pig embryo regulation factor is mixed by following component:
Sulfuric acid oestrogenic hormone 0.02%--0.04%
All the other are distilled water for glucose 1%--2%.
2. pig embryo regulation factor according to claim 1, preparation in accordance with the following methods:
A. glucose is added in the distilled water and evenly mix;
B. make the heating of glucose dissolving mixed liquor, until boiling;
C. the glucose mixed liquor after will seething with excitement is cooled to 40 ℃;
D. add sulfuric acid oestrogenic hormone;
E. dissolving mixes the back sub-bottle packaging.
3. pig embryo regulation factor according to claim 1 is characterized in that: described sulfuric acid oestrogenic hormone is beta estradiol 3-sulphate (β-Estradial 3-sulfate), and its molecular formula is: C
18H
23OSN
a, structural formula is: 1.3.5[10]-Estratriene-3,17-β-di ol, 3sulfate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00112089 CN1119929C (en) | 2000-02-24 | 2000-02-24 | Pig embryo regulation factor and its preparing process and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00112089 CN1119929C (en) | 2000-02-24 | 2000-02-24 | Pig embryo regulation factor and its preparing process and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1260954A CN1260954A (en) | 2000-07-26 |
| CN1119929C true CN1119929C (en) | 2003-09-03 |
Family
ID=4581977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00112089 Expired - Fee Related CN1119929C (en) | 2000-02-24 | 2000-02-24 | Pig embryo regulation factor and its preparing process and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1119929C (en) |
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2000
- 2000-02-24 CN CN 00112089 patent/CN1119929C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1260954A (en) | 2000-07-26 |
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