CN111950664A - Laboratory information management method for gene detection and inspection - Google Patents
Laboratory information management method for gene detection and inspection Download PDFInfo
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- G06K17/00—Methods or arrangements for effecting co-operative working between equipments covered by two or more of main groups G06K1/00 - G06K15/00, e.g. automatic card files incorporating conveying and reading operations
- G06K17/0022—Methods or arrangements for effecting co-operative working between equipments covered by two or more of main groups G06K1/00 - G06K15/00, e.g. automatic card files incorporating conveying and reading operations arrangements or provisions for transferring data to distant stations, e.g. from a sensing device
- G06K17/0029—Methods or arrangements for effecting co-operative working between equipments covered by two or more of main groups G06K1/00 - G06K15/00, e.g. automatic card files incorporating conveying and reading operations arrangements or provisions for transferring data to distant stations, e.g. from a sensing device the arrangement being specially adapted for wireless interrogation of grouped or bundled articles tagged with wireless record carriers
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Abstract
The application discloses a gene detection and inspection laboratory information management method, which comprises the steps of collecting experimental equipment data; collecting data of the UWB positioning system; collecting data of the radio frequency tag system; collecting data of the image collection system; the data are correlated and matched in the local server and transmitted to the cloud server; and the cloud server sends part or all of the data to the mobile terminal according to the request of the mobile terminal user and the permission level. The method has the beneficial effects that the gene detection examination laboratory information management method which enables data collection and sharing to be more convenient and faster through automatic detection collection and wireless communication technology is provided.
Description
Technical Field
The application relates to a gene detection laboratory information management method.
Background
The gene is a genetic basic unit, carries DNA or RNA sequence of genetic information, transmits the genetic information to the next generation through replication, and guides the synthesis of protein to express the genetic information carried by the gene, thereby controlling the character expression of organism individuals. The gene detection is a technique for detecting DNA by blood, other body fluids or cells, and is a method for taking peripheral venous blood or other tissue cells of a detected person, amplifying the gene information, detecting DNA molecular information in the cells of the detected person by a specific device, and analyzing whether the gene type, the gene defect and the expression function contained in the DNA molecular information are normal or not, so that people can know the gene information of themselves, and the etiology is determined or the risk of a certain disease of the body is predicted.
The intelligent degree of the existing gene detection is low, and users and managers are inconvenient to acquire experimental data.
Disclosure of Invention
A gene detection laboratory information management method is applied to a gene detection laboratory information management system; the gene detection laboratory information management system comprises: the system comprises a laboratory system, a cloud server and a mobile terminal; wherein the laboratory system comprises: the experimental equipment is used for realizing an experimental function; the UWB positioning system is used for positioning the experimental equipment; the radio frequency tag system is used for realizing data interaction of the radio frequency tag; the image acquisition system is used for acquiring image information; the local server can respectively perform data interaction with the UWB positioning system, the radio frequency tag system and the image acquisition system and process data uploaded by the UWB positioning system, the radio frequency tag system and the image acquisition system; the cloud server and the local server form communication connection; the mobile terminal and the cloud server form wireless communication connection; the information management method for the gene detection laboratory comprises the following steps: collecting the experimental equipment data; collecting data of the UWB positioning system; collecting data of the radio frequency tag system; collecting data of the image collection system; the data are correlated and matched in the local server and transmitted to the cloud server; and the cloud server sends part or all of the data to the mobile terminal according to the request of the mobile terminal user and the permission level.
Further, the laboratory system further comprises: a first type of container having at least one first type of radio frequency tag; a second type container, at least having a second type radio frequency tag; the pipettor is used for transferring the liquid in the first type of container to the second type of container and is provided with a third type of radio frequency tag.
Further, the laboratory system further comprises: and the PCR device is used for carrying out PCR treatment on the liquid in the second type container.
Further, the laboratory system further comprises: and the external tag management device is used for reading or writing data of the first type of radio frequency tag, the second type of radio frequency tag and the third type of radio frequency tag.
Further, the laboratory system further comprises: and the external image acquisition device is used for acquiring the image data of the first type container, the second type container and the pipettor.
Further, the laboratory system further comprises: the electrophoresis apparatus is used for carrying out electrophoretic analysis on the liquid in the second type container; the electrophoresis apparatus is provided with a built-in label management module for reading the second type of radio frequency label; the electrophoresis apparatus is provided with a built-in image acquisition module for acquiring images of the second type of container.
Further, the laboratory system shown comprises: the superclean bench is used for carrying out experiments; the sensor is used for detecting the environmental condition of the experimental superclean bench; the sensor and the local server form data interaction.
Further, the sensor directly forms data interaction with a cloud server.
Further, an NB-IoT module is arranged in the sensor to communicate with the cloud server.
Further, the sensor comprises one or more of a temperature sensor, a humidity sensor, an optical sensor and a gravity sensor.
The application has the advantages that: the gene detection laboratory information management method enables data collection and sharing to be more convenient and fast through automatic detection collection and wireless communication technology.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this application, serve to provide a further understanding of the application and to enable other features, objects, and advantages of the application to be more apparent. The drawings and their description illustrate the embodiments of the invention and do not limit it. In the drawings:
FIG. 1 is a block diagram schematically illustrating the structure of a genetic testing laboratory information management system according to an embodiment of the present application;
FIG. 2 is a block diagram of a schematic configuration of a laboratory system according to an embodiment of the present application;
FIG. 3 is a more detailed schematic block diagram of a laboratory system according to an embodiment of the present application;
FIG. 4 is a schematic diagram of a first type of container according to an embodiment of the present application;
FIG. 5 is a schematic diagram of a second type of container according to an embodiment of the present application;
FIG. 6 is a schematic diagram of a second type of container according to another embodiment of the present application;
fig. 7-9 are schematic diagrams of laboratory system steps according to an embodiment of the present application.
FIGS. 10 to 11 are schematic diagrams of interaction between each device and a server in an intelligent gene testing and analyzing system according to an embodiment of the present application.
The meaning of the reference symbols in the figures:
a container 200, an open vessel 201, a mounting band 202 and a label box 203; a PCR tube 300, a tube body 301, a label tape 302, and a cap 303; a PCR sample plate 400, a plate body 401, a tube body 402, a tag patch 403 and a UWB tag 404; the system comprises a server 501, a downward shooting camera 502, a horizontal shooting camera 503, an external label management device 504, a first container 505, a pipettor 506 and a second container 507; PCR device 600, electrophoresis apparatus 700.
Detailed Description
In order to make the technical solutions better understood by those skilled in the art, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only partial embodiments of the present application, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
It should be noted that the terms "first," "second," and the like in the description and claims of this application and in the drawings described above are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It should be understood that the data so used may be interchanged under appropriate circumstances such that embodiments of the application described herein may be used. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.
In this application, the terms "upper", "lower", "left", "right", "front", "rear", "top", "bottom", "inner", "outer", "middle", "vertical", "horizontal", "lateral", "longitudinal", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings. These terms are used primarily to better describe the present application and its embodiments, and are not used to limit the indicated devices, elements or components to a particular orientation or to be constructed and operated in a particular orientation.
Moreover, some of the above terms may be used to indicate other meanings besides the orientation or positional relationship, for example, the term "on" may also be used to indicate some kind of attachment or connection relationship in some cases. The specific meaning of these terms in this application will be understood by those of ordinary skill in the art as appropriate.
Furthermore, the terms "mounted," "disposed," "provided," "connected," and "sleeved" are to be construed broadly. For example, it may be a fixed connection, a removable connection, or a unitary construction; can be a mechanical connection, or an electrical connection; may be directly connected, or indirectly connected through intervening media, or may be in internal communication between two devices, elements or components. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art as appropriate.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present application will be described in detail below with reference to the embodiments with reference to the attached drawings.
As shown in fig. 1 to 11, the information management system for a genetic testing laboratory includes: the system comprises a laboratory system, a cloud server and a mobile terminal; wherein the laboratory system comprises: the experimental equipment is used for realizing an experimental function; the UWB positioning system is used for positioning the experimental equipment; the radio frequency tag system is used for realizing data interaction of the radio frequency tag; the image acquisition system is used for acquiring image information; the local server can respectively carry out data interaction with the UWB positioning system, the radio frequency tag system and the image acquisition system and process data uploaded by the UWB positioning system, the radio frequency tag system and the image acquisition system; the cloud server and the local server form communication connection; the mobile terminal and the cloud server form wireless communication connection.
In particular, the laboratory system further comprises: a first type of container having at least one first type of radio frequency tag; a second type container, at least having a second type radio frequency tag; the liquid transfer device is used for transferring the liquid in the first type of container to the second type of container and is provided with a third type of radio frequency tag.
In particular, the laboratory system further comprises: and the PCR device is used for carrying out PCR treatment on the liquid in the second type container.
In particular, the laboratory system further comprises: and the external tag management device is used for reading or writing data of the first type of radio frequency tag, the second type of radio frequency tag and the third type of radio frequency tag.
In particular, the laboratory system further comprises: the external image acquisition device is used for acquiring image data of the first type container, the second type container and the liquid transfer device.
In particular, the laboratory system further comprises: the electrophoresis apparatus is used for carrying out electrophoretic analysis on the liquid in the second type container; the electrophoresis apparatus is provided with a built-in label management module for reading a second type of radio frequency label; the electrophoresis apparatus is provided with a built-in image acquisition module to acquire images of the second type of container.
In particular, the laboratory system shown comprises: the superclean bench is used for carrying out experiments; the sensor is used for detecting the environmental condition of the experimental superclean bench; the sensors and the local server form data interaction.
Specifically, the sensor directly forms data interaction with the cloud server.
Specifically, the sensor is internally provided with an NB-IoT module to communicate with the cloud server.
Specifically, the sensor includes one or more of a temperature sensor, a humidity sensor, an optical sensor, and a gravity sensor.
By adopting the scheme, various data of a laboratory can be uploaded to the cloud server, and then a user can obtain the required data of the user by the mobile terminal. The cloud server can send different data to different users according to the permission of the mobile terminal user. For example, the test patient sends the test results, while the administrator sends data such as the test environment, reagents, test procedures, etc., thereby enabling the administrator to manage the data and the laboratory in a comprehensive manner.
As another aspect of the present application, the gene testing laboratory information management method of the present application includes: collecting experimental equipment data; collecting data of a UWB positioning system; collecting data of a radio frequency tag system; collecting data of an image collection system; the data are correlated and matched in a local server and transmitted to a cloud server; the cloud server sends part or all of the data to the mobile terminal according to the request of the mobile terminal user and the permission level.
As an extension scheme, the cloud server divides different security levels for each laboratory, the security levels relate to the geographic locations of the laboratories, and except for a super administrator, local server administrators in different domains cannot access data uploaded by other local servers in the cloud server.
Preferably, the mobile terminal can use an applet for data access.
The laboratory system comprises: the device comprises a first type container, a second type container, a pipettor, a PCR device, an external label management device, an external image acquisition device and a local server.
Wherein the first type container is provided with at least one first type radio frequency label; the second type container is provided with at least one second type radio frequency label; the pipettor is used for transferring the liquid in the first type of container to the second type of container and is provided with a third type of radio frequency tag; the PCR device is used for carrying out PCR treatment on the liquid in the second type of container; the external tag management device is used for reading or writing data of the first type of radio frequency tag, the second type of radio frequency tag and the third type of radio frequency tag; the external image acquisition device is used for acquiring image data of the first type container, the second type container and the liquid transfer device; the local server is used for storing and processing the data transmitted by the external label management device and the external image acquisition device and associating the data.
The local server can acquire container data and data of the pipettor through the external image acquisition device and the external label management device, so that data and results required by detection can be intelligently acquired. The external image acquisition device can comprise one or more cameras, the external tag management device comprises one or more radio frequency tag readers-writers arranged at specific positions (such as different working procedure positions), and the radio frequency tag readers-writers have a wireless remote reading-writing function and can read or write data of the radio frequency tags through the coupling coils.
Specifically, the first type of container comprises an open vessel, and the first type of radio frequency tag is configured as a mounting band and a tag box which are sleeved on the periphery of the open vessel. The first type container can be used as a storage container or a transit container, and can be matched in a local server by collecting two-dimensional code data arranged on a label box and data of a radio frequency label and identify the type of liquid in the container.
The second type of container comprises a PCR tube, and the second type of radio frequency tag is configured as a tag tape which is sleeved on the periphery of the PCR tube, particularly the tube body. Preferably, the seal cover of the PCR test tube is provided with a sun code. After the PCR test tube is injected with liquid through a pipettor, the liquid in the container can be remarked through the radio frequency tag and the solar code.
As a second type of container, a PCR sample plate is included, and the second type of radio frequency tag is configured as a tag patch embedded in the PCR sample plate. The PCR sample plate comprises a plate body and a tube body, and the PCR sample plate can be placed into the PCR device and the electrophoresis apparatus in batches so as to realize batch detection. The tag paster can be embedded in the plate body, and as the extension scheme, PCR sample board still includes the UWB tag, can send out the UWB signal to realize the location to PCR sample board. In addition, identification codes, such as two-dimensional codes or bar codes, preferably bar codes, are engraved on the plate body at positions corresponding to different pipe bodies through laser etching. For batch application, the PCR sample plate may be etched with the same bar code corresponding to the nozzle of each tube, and further an identification condition is added by the rf tag of the PCR sample plate.
As a specific scheme, a third type of radio frequency tag is arranged in the pipettor, and the pipettor is further provided with a wireless communication module and a controller, so that the pipettor can upload data to a local server by acquiring the pipetting volume of the pipettor.
More specifically, the identification code is also attached to the exterior of the pipette. During pipetting operations, the two cameras determine the pipetting direction by acquiring images.
As a specific scheme, the PCR device is provided with a built-in label management module to read the second type of radio frequency label. And, the PCR device is provided with a built-in image acquisition module to acquire images of the second type of containers. Thus, the PCR device can collect the processed sample through the radio frequency data and the image data.
Specifically, the intelligent gene detection analysis system further comprises an electrophoresis apparatus. The electrophoresis apparatus is used for carrying out electrophoretic analysis on the liquid in the second type container; the electrophoresis apparatus is provided with a built-in label management module to read the second type of radio frequency label. And the electrophoresis apparatus is provided with a built-in image acquisition module to acquire images of the second type of container. Thus, the electrophoresis apparatus can collect the detected samples by radio frequency data and image data, and transmit the corresponding detection structures to the local server according to the identification information.
As an extension, the pipettor, the PCR device and the electrophoresis apparatus and the local server may transmit data by wireless communication.
As an extension, other sensors may also be provided to capture weight or other physical quantities required by the system.
The application also provides a gene data acquisition method, which comprises the following steps: the tag management device acquires data of a first type of radio frequency tag of a first type of container; the tag management device collects data of a second type of radio frequency tag of a second type of container; the method comprises the following steps that a label management device acquires data of a third type of radio frequency label of the pipettor; the PCR device collects data of a second type of radio frequency tag of a second type of container; the server processes and associates the data of the PCR device and the data collected from the second type of radio frequency tags.
The method specifically comprises the following steps: at first process position department, set up and bow to take a photograph the camera and violently take a photograph camera and external label management equipment, as the extension scheme, still be provided with a gravity sensor.
When the pipettor is adopted to suck liquid from the first type of container, the graphic label data and the radio frequency label data of the first type of container and the pipettor are collected, so that the server can know the type and the liquid taking amount of the liquid and record the data of the pipettor. The gravity sensor can check the liquid taking amount and record the remaining amount.
As an extension, the data acquisition may be triggered by the camera once a specific graphic label entering the field of view is acquired.
As a further development, the acquisition of data can be triggered by an operating movement of the pipette or by a positional movement of the pipette. Preferably, the pipettor is provided with a UWB tag or a gyroscope to identify a change in position of the pipettor.
In second process position department, also can set up the first process position of overhead camera and horizontal shooting camera and external label management equipment and second process position can separate certain distance, of course, also can adopt the mode of physical isolation, for example adopt the mode of shielding baffle to realize.
When the collection pipettor injects liquid into the second type container, the graphic tag data and the radio frequency tag data of the second type container and the pipettor are collected, so that the server can know the type of the injected liquid and the liquid taking amount and record the data of the pipettor. It should be noted here that the graphics data of the second type container needs to adopt a different graphics from the first type container.
The graphic label of the first container is a two-dimensional code, and the graphic label of the second container is a sun code or a bar code, so that different equipment can be conveniently identified and distinguished.
And (3) sequentially placing the second type of container into the PCR equipment and the electrophoresis apparatus so as to obtain the source of the sample, and combining the detection result, the process procedure and the sample source to realize intelligent detection.
The above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.
Claims (10)
1. A gene detection laboratory information management method is applied to a gene detection laboratory information management system; the method is characterized in that:
the gene detection laboratory information management system comprises:
the system comprises a laboratory system, a cloud server and a mobile terminal;
wherein the laboratory system comprises:
the experimental equipment is used for realizing an experimental function;
the UWB positioning system is used for positioning the experimental equipment;
the radio frequency tag system is used for realizing data interaction of the radio frequency tag;
the image acquisition system is used for acquiring image information;
the local server can respectively perform data interaction with the UWB positioning system, the radio frequency tag system and the image acquisition system and process data uploaded by the UWB positioning system, the radio frequency tag system and the image acquisition system;
the cloud server and the local server form communication connection; the mobile terminal and the cloud server form wireless communication connection;
the information management method for the gene detection laboratory comprises the following steps:
collecting the experimental equipment data;
collecting data of the UWB positioning system;
collecting data of the radio frequency tag system;
collecting data of the image collection system;
the data are correlated and matched in the local server and transmitted to the cloud server;
and the cloud server sends part or all of the data to the mobile terminal according to the request of the mobile terminal user and the permission level.
2. The information management method for a genetic testing laboratory according to claim 1, characterized in that:
the laboratory system further comprises:
a first type of container having at least one first type of radio frequency tag;
a second type container, at least having a second type radio frequency tag;
the pipettor is used for transferring the liquid in the first type of container to the second type of container and is provided with a third type of radio frequency tag.
3. The information management method for a genetic testing laboratory according to claim 2, characterized in that:
the laboratory system further comprises:
and the PCR device is used for carrying out PCR treatment on the liquid in the second type container.
4. The information management method for a genetic testing laboratory according to claim 3, characterized in that:
the laboratory system further comprises:
and the external tag management device is used for reading or writing data of the first type of radio frequency tag, the second type of radio frequency tag and the third type of radio frequency tag.
5. The information management method for a genetic testing laboratory according to claim 4, characterized in that:
the laboratory system further comprises:
and the external image acquisition device is used for acquiring the image data of the first type container, the second type container and the pipettor.
6. The information management method for a genetic testing laboratory according to claim 5, characterized in that:
the laboratory system further comprises:
the electrophoresis apparatus is used for carrying out electrophoretic analysis on the liquid in the second type container;
the electrophoresis apparatus is provided with a built-in label management module for reading the second type of radio frequency label; the electrophoresis apparatus is provided with a built-in image acquisition module for acquiring images of the second type of container.
7. The information management method for a genetic testing laboratory according to claim 1, characterized in that:
the laboratory system shown comprises:
the superclean bench is used for carrying out experiments;
the sensor is used for detecting the environmental condition of the experimental superclean bench;
the sensor and the local server form data interaction.
8. The information management method for a genetic testing laboratory according to claim 7, characterized in that:
the sensor directly forms data interaction with the cloud server.
9. The information management method for a genetic testing laboratory according to claim 8, characterized in that:
an NB-IoT module is arranged in the sensor to communicate with the cloud server.
10. The information management method for a genetic testing laboratory according to claim 1, characterized in that:
the sensor comprises one or more of a temperature sensor, a humidity sensor, an optical sensor and a gravity sensor.
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| CN109788066A (en) * | 2019-01-30 | 2019-05-21 | 北京金科汇智科技有限公司 | A kind of material tests test process record system and method based on image |
| CN110699253A (en) * | 2019-11-29 | 2020-01-17 | 上海百傲科技股份有限公司 | Gene detection system and gene detection method |
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