CN111944670B - Ultrasonic processor - Google Patents
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- CN111944670B CN111944670B CN202010197515.0A CN202010197515A CN111944670B CN 111944670 B CN111944670 B CN 111944670B CN 202010197515 A CN202010197515 A CN 202010197515A CN 111944670 B CN111944670 B CN 111944670B
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- 238000012360 testing method Methods 0.000 claims abstract description 29
- 238000000034 method Methods 0.000 claims abstract description 10
- 230000008569 process Effects 0.000 claims abstract description 8
- 230000005284 excitation Effects 0.000 claims description 9
- 230000009977 dual effect Effects 0.000 claims description 5
- 238000002604 ultrasonography Methods 0.000 claims description 5
- 239000000523 sample Substances 0.000 description 70
- 230000000694 effects Effects 0.000 description 8
- 239000012472 biological sample Substances 0.000 description 6
- 239000007788 liquid Substances 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000003491 array Methods 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M45/00—Means for pre-treatment of biological substances
- C12M45/02—Means for pre-treatment of biological substances by mechanical forces; Stirring; Trituration; Comminuting
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/06—Hydrolysis; Cell lysis; Extraction of intracellular or cell wall material
Abstract
The invention discloses an ultrasonic processor, which comprises a focusing acoustic lens, an ultrasonic transducer, a sample processing groove and a test tube bracket. The ultrasonic transducer excites the focusing acoustic lens, and the sample is placed at the focus of the focusing acoustic lens through the test tube support. The double-focusing ultrasonic processor utilizes two focusing sound fields to process a sample, and the two focusing sound lenses reflect sound waves mutually, so that the sound field intensity at the focus is enhanced, and the energy utilization rate is improved.
Description
Technical Field
The invention relates to a biological sample processing device, in particular to a double-focusing ultrasonic processor.
Background
The ultrasonic wave vibrates in the liquid to generate small bubbles, and the phenomenon that the small bubbles are enlarged and then violently collapse to generate high-speed jet flow is called as the cavitation effect of the ultrasonic wave. The high-speed jet flow generated by the ultrasonic cavitation effect can realize the crushing of samples such as cells, biological tissues and the like. The common ultrasonic processor has two main structural forms: contact and non-contact, wherein non-contact ultrasonic processor need not to contact ultrasonic probe and sample at sample treatment in-process, avoids secondary pollution, and can handle multiunit sample simultaneously, and the treatment effeciency is high, compares and has obvious advantage in contact ultrasonic processor.
Generally, the stronger the sound field energy is, the better the sample processing effect is, the existing non-contact ultrasonic processor mainly adopts the bottom vibration mode of an ultrasonic transducer, and the structure has the problems of uneven sound field energy distribution, low energy utilization efficiency and the like. Therefore, the double-focusing ultrasonic processor capable of effectively improving the sound field intensity of the sample area to be processed, improving the sample processing uniformity and improving the sound field energy utilization efficiency has extremely important significance for improving the biological sample processing quality and reducing the biological sample processing cost.
Disclosure of Invention
In order to solve the above problems, the present inventors have conducted intensive studies and, as a result, have found that: the two focusing acoustic lenses are utilized to excite the focusing acoustic field in the sample processing groove from the side surface to process the sample, and the two focusing acoustic lenses can reflect the acoustic waves mutually, so that the processing quality and efficiency of the sample are improved, and the invention is completed.
The invention aims to provide an ultrasonic processor, in particular a double-focusing ultrasonic processor, comprising: the ultrasonic testing device comprises a focusing acoustic lens, an ultrasonic transducer, a sample processing groove and a test tube bracket; wherein the content of the first and second substances,
the test tube bracket is arranged at the top of the sample processing groove and is provided with a test tube placing hole for fixing a sample;
the two focusing acoustic lenses are respectively arranged on the inner sides of the side walls of the sample processing tank, and the ultrasonic transducer is arranged at the center of the back of the focusing acoustic lens and used for exciting the focusing acoustic lens to excite the internal focusing acoustic field of the sample processing tank so as to process the sample.
Wherein the focal positions of the focusing acoustic lenses coincide.
Preferably, the focusing radii of the focusing acoustic lenses are the same; or the focusing radii of the focusing acoustic lenses are different, and the absolute value of the focusing radius difference of the focusing acoustic lenses is not equal to the integral multiple of the half wavelength of the ultrasonic wave.
Further, the heights of the focusing acoustic lenses on the side walls of the sample processing tank are the same or different.
The ultrasonic transducer is an ultrasonic transducer array, is arranged on the outer side of the side wall of the sample processing groove and is arranged along the extending direction of the focusing acoustic lens.
Further, the ultrasonic transducers on two sides of the sample processing groove are arranged in a staggered mode.
Preferably, the ultrasonic transducers on the same side of the sample processing well are of the same height.
Further, the double-focusing ultrasonic processor has three working modes:
the excitation frequencies of the two focusing acoustic lenses are the same;
the excitation frequencies of the two focusing acoustic lenses are different;
only one of the two focusing acoustic lenses vibrates, and the other one serves as a reflecting surface.
Preferably, the focusing acoustic lens is fixed on the inner side of the side wall of the sample processing groove in an adhering mode.
Preferably, the sample processing tank is a rectangular parallelepiped, and the focusing acoustic lens is disposed inside the long-side wall of the sample processing tank and extends along the long-side wall.
The double-focusing ultrasonic processor provided by the invention has the following beneficial effects:
(1) the double-focusing ultrasonic processor provided by the invention utilizes the two focusing acoustic lenses to excite the focusing sound field in the sample processing groove from the side surface to process the sample, and simultaneously, the two focusing acoustic lenses reflect sound waves mutually, so that the intensity of the sound field at the focus is enhanced, and the energy utilization efficiency is improved;
(2) the double-focusing ultrasonic processor provided by the invention can select different working modes, improve the sample processing quality and processing efficiency, and realize energy-saving processing of a small amount of samples.
Drawings
FIG. 1 shows a schematic cross-sectional view of a dual focus type ultrasonic processor with the same height of the focused acoustic lens arrangement;
FIG. 2 illustrates a perspective assembly view of a preferred embodiment dual focus ultrasound processor;
FIG. 3 is a schematic cross-sectional view of a dual focusing ultrasonic processor with different focusing acoustic lens setting heights;
figure 4 shows a schematic top view of a preferred embodiment dual focus ultrasound processor.
The reference numbers illustrate:
1-focusing acoustic lens
2-ultrasonic transducer
3-sample treatment tank
4-test tube holder
Detailed Description
The features and advantages of the present invention will become more apparent and appreciated from the following detailed description of the invention, as illustrated in the accompanying drawings.
The word "exemplary" is used exclusively herein to mean "serving as an example, embodiment, or illustration. Any embodiment described herein as "exemplary" is not necessarily to be construed as preferred or advantageous over other embodiments. While the various aspects of the embodiments are presented in drawings, the drawings are not necessarily drawn to scale unless specifically indicated.
In the description of the present invention, it should be noted that the terms "upper", "lower", "inner", "outer", "front", "rear", "left" and "right" and the like indicate orientations or positional relationships based on an operating state of the present invention, and are only for convenience of description and simplification of description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation and be operated, and thus, should not be construed as limiting the present invention.
The present invention is described in detail below.
The invention provides an ultrasonic processor, which comprises a focusing acoustic lens 1, an ultrasonic transducer 2, a sample processing groove 3 and a test tube bracket 4. The ultrasonic processor is particularly useful in the processing of biological samples, such as cells, biological tissues, nucleotide fragments, and the like.
The sample processing tank 3 is a rectangular parallelepiped container with an open top, and the container holds a liquid (e.g., water) therein as a processing space for the sample. The rectangular sample processing groove 3 is beneficial to in-line distribution of samples to be processed, improves the sample processing capacity and simultaneously ensures that the intensity of ultrasonic processing sound fields applied to the samples is basically the same.
A plano-concave acoustic lens is used as the focusing acoustic lens 1 in the present invention. In particular, the present invention inventively provides the focusing acoustic lens 1 inside the sidewall of the sample processing well 3 and extending along the long side of the sample processing well 3. Preferably, two focusing acoustic lenses 1 are arranged and respectively arranged at the inner sides of the parallel long-side walls of the sample processing tank 3; more preferably, the focusing acoustic lenses 1 should be oppositely arranged, i.e. both ends of the two focusing acoustic lenses 1 are substantially flat at the long side walls of the sample processing bath 3.
In the invention, the focal positions of the two focusing acoustic lenses 1 are preferably superposed, so that the sound field intensity at the focal position can be enhanced; meanwhile, the focusing acoustic lens 1 can reflect sound waves mutually when in work, so that the focus of the reflected sound waves is the same as that of the focusing acoustic lens 1, the sound field intensity at the focus is further enhanced, and the energy utilization rate is improved.
The radii of the two focusing acoustic lenses 1 may be the same or different, as long as the focal positions of the two focusing acoustic lenses 1 are kept coincident.
In a preferred embodiment, the two focusing acoustic lenses 1 have the same focusing radius, and when viewed along the long side wall of the sample processing chamber 3, the focusing acoustic lenses 1 are symmetrically fixed on the inner side of the parallel side walls of the sample processing chamber 3, as shown in fig. 1.
In another preferred embodiment, the two focusing acoustic lenses 1 may also have different focusing radii, and in this case, the focusing acoustic lenses 1 are asymmetrically fixed at both ends of the short side wall of the sample processing well 3, when viewed along the direction of the long side wall of the sample processing well 3.
When the radii of the two focusing acoustic lenses 1 are different, in order to avoid the reduction of the sound field intensity caused by mutual cancellation of the ultrasonic sound waves, the absolute value of the radius difference of the two focusing acoustic lenses 1 should not be equal to the integral multiple of the half wavelength of the ultrasonic waves. Specifically, the focal length of the focusing acoustic lens 1 on one side is R1, the focal length of the focusing acoustic lens 1 on the other side is R2, and the operating frequency of the ultrasonic transducer 2 is f, so as to avoid mutual cancellation between sound pressures, it must satisfy | R1-R2 ≠ nc/(2f), where n ═ 1,2,3 …, n is an integer, and c is the sound velocity of the processed sample (≈ 1500 m/s).
In addition, the two focusing acoustic lenses 1 may be arranged at the same height on the side wall or at different heights on the side wall.
In a preferred embodiment, the focusing acoustic lenses 1 are arranged at the same height on parallel sides, as shown in fig. 1.
In a preferred embodiment, the focusing acoustic lens 1 is disposed at different heights on the parallel side surfaces, and more preferably, the two are offset by a certain distance in the height direction, so that the size of the focusing region in the height direction can be increased, as shown in fig. 3. The staggered distance is smaller than the height of the focusing acoustic lens, and the specific distance can be set arbitrarily according to the height of a required focusing area.
Further, the excitation frequency of the focusing acoustic lens 1 can be set to be the same frequency or different frequencies according to actual requirements, so as to improve the crushing degree of the sample or the crushing uniformity of the sample. The preferred operating frequency of the focusing acoustic lens 1 is between 20KHz and 20 MHz.
The focusing acoustic lens 1 can be fixed on the inner side of the sidewall of the sample processing chamber 3 by any fixing method in the prior art, such as adhesion fixing, as long as the focusing acoustic lens 1 and the sidewall of the sample processing chamber 3 can be firmly fixed.
An ultrasonic transducer is arranged on the outer side of the side wall of the sample processing groove 3 provided with the focusing acoustic lens 1, and the ultrasonic transducer 2 excites the focusing acoustic lens 1 through the side wall of the sample processing groove 3 to excite the focusing acoustic field in the sample processing groove 3 to process a sample.
The ultrasonic transducer 2 converts the input electric power into mechanical power, i.e., ultrasonic waves, and transmits the mechanical power. Further, the ultrasonic transducer 2 is an ultrasonic transducer array, the ultrasonic transducer array is composed of a plurality of ultrasonic transducer units, and the ultrasonic transducer units in each ultrasonic transducer array are driven in parallel by the same ultrasonic power supply. The ultrasonic transduction units in the ultrasonic transducer array are preferably of the same frequency and the same type.
The ultrasonic transducer unit is an ultrasonic transducer sheet, preferably a piezoelectric ceramic sheet or a sandwich type transducer.
The number of the ultrasonic transducer units is positively correlated with the working power of the ultrasonic transducer 2, and the working power of the ultrasonic transducer 2 is higher when the number of the ultrasonic transducer units is larger. It is preferable to set different operating powers for the ultrasonic transducers 2 depending on the processing targets of the ultrasonic processors.
Preferably, the ultrasonic transducer arrays are arranged along the extending direction of the focusing acoustic lens 1, and more preferably, the ultrasonic transducer units on the same ultrasonic transducer array are located at the same height and are all located at the central position of the back of the focusing acoustic lens 1, as shown in fig. 2.
The ultrasonic transducer units on the same side of the ultrasonic processor are separated by a set distance, and the separation can be set according to the volume size of the ultrasonic processor, the working power of the ultrasonic transducer 2, the sample processing effect to be obtained and the like.
In a preferred embodiment, the ultrasonic transducers 2 on both sides of the ultrasonic processor are not symmetrically disposed opposite to each other, but are staggered in the horizontal direction by a set distance (or interval) to improve the spatial uniformity of the focused sound field in the horizontal direction, as shown in fig. 4.
The distance of the ultrasonic transducers 2 staggered on both sides of the ultrasonic processor is related to the size or length of the ultrasonic processor. In a preferred embodiment, the ultrasound transducer 2 is disposed opposite to the gap between two adjacent ultrasound transducers 2 on the opposite side.
And applying voltage on the ultrasonic transducer, exciting the focusing acoustic lens by the ultrasonic transducer to generate a focusing acoustic field with the same frequency or different frequencies at a focus, reflecting sound waves by the two focusing acoustic lenses to enhance the intensity of the focusing acoustic field, and processing the biological sample in the test tube by utilizing the cavitation effect of the focusing acoustic field at the focus.
The operating voltage of the ultrasonic transducer may be a common-frequency or non-common-frequency excitation voltage, and in particular, the non-common-frequency voltage may increase the uniformity of the treatment.
Further, a test tube holder 4 capable of covering the opening is provided at the opening of the sample processing bath 3, and the test tube holder 4 is movably or fixedly provided at the top end of the sample processing bath 3, preferably at the top end of the sample processing bath 3. The tube holder 4 can slow down the evaporation loss of the liquid contained in the sample processing well 3 when the ultrasonic processor is operated.
Be provided with the test tube on test tube holder 4 and place the hole, the test tube passes this test tube and places the hole and get into sample processing groove 3 in, test tube holder 4 carries out spacing fixed to the test tube, prevents that the test tube from empting in sample processing groove 3. The sample to be processed is placed in the test tube, and then the test tube with the sample is placed in the sample processing groove 3 through the test tube placing hole on the test tube bracket 4, so that the non-contact processing of the sample and the ultrasonic processor is realized.
Further, the cuvette holding hole is provided above the focusing area of the focusing acoustic lens 1, and is located at the focal point or focusing area of the two focusing acoustic lenses 1 when the cuvette is entered into the sample processing bath 3 through the cuvette holding hole. The double-focusing ultrasonic processor utilizes a focusing sound field generated by the two focusing acoustic lenses 1 to process a sample, and the two focusing acoustic lenses 1 reflect sound waves mutually, so that the sound field intensity at the focus is enhanced, the energy utilization rate is improved, the sound field intensity and the cavitation effect of the focusing sound field are maximum, and the biological sample processing effect is optimal.
In a preferred embodiment, as shown in figures 2 and 4, the test tube holder 4 is provided with a plurality of test tube placement holes, more preferably arranged in-line. The number of the test tube placing holes can be set according to actual requirements, such as 2 or 8.
Note that, when the focusing radii of the two focusing acoustic lenses 1 are different, the cuvette holding hole may not be located at the middle position on the cuvette holder 4, and may be shifted.
The double-focusing ultrasonic processor provided by the invention has three working modes: the two focusing acoustic lenses 1 have the same vibration frequency (excitation frequency); the vibration frequencies of the two focusing acoustic lenses are different; only one of the two focusing acoustic lenses vibrates, and the other one serves as a reflecting surface.
During working, the double-focusing ultrasonic processor can select the following three working modes to realize different effects:
the ultrasonic transducers 2 on two sides of the sample processing tank 3 have the same excitation frequency, the sound field intensity at the focus of the focusing acoustic lens 1 is high, and the sample processing efficiency is high;
the ultrasonic transducers on the two sides of the sample processing tank 3 have different excitation frequencies, so that the sample processing uniformity is good;
only one side of the ultrasonic transducers at the two sides of the sample processing groove 3 works, so that energy is saved when a small amount of samples are processed.
The double-focusing ultrasonic processor provided by the invention utilizes the two focusing acoustic lenses 1 to excite the focusing sound field in the sample processing groove 3 from the side surface to process the sample, different working modes can be selected, the sample processing quality is improved, and meanwhile, the two focusing acoustic lenses reflect sound waves mutually, so that the energy utilization efficiency is improved.
The invention has been described in detail with reference to specific embodiments and illustrative examples, but the description is not intended to be construed in a limiting sense. Those skilled in the art will appreciate that various equivalent substitutions, modifications or improvements may be made to the technical solution of the present invention and its embodiments without departing from the spirit and scope of the present invention, which fall within the scope of the present invention. The scope of the invention is defined by the appended claims.
Claims (2)
1. A dual focus ultrasound processor, comprising: a focusing acoustic lens (1), an ultrasonic transducer (2), a sample processing groove (3) and a test tube bracket (4);
the test tube support (4) is arranged at the top of the sample processing groove (3), and is provided with a test tube placing hole for fixing a sample, and the test tube placing hole is arranged above a focusing area of the focusing acoustic lens (1);
the two focusing acoustic lenses (1) are respectively arranged on the inner sides of the parallel side walls of the sample processing tank (3), and the ultrasonic transducer (2) is arranged at the center of the back of the focusing acoustic lens (1) and used for exciting the focusing acoustic lens (1) and exciting a focusing sound field in the sample processing tank (3) so as to process a sample;
the focusing radii of the focusing acoustic lenses (1) are different, and the absolute value of the focusing radius difference of the focusing acoustic lenses (1) is not equal to the integral multiple of the half wavelength of the ultrasonic wave;
the heights of the focusing acoustic lenses (1) on the side wall of the sample processing tank (3) are different, the focusing acoustic lenses and the sample processing tank are staggered by a certain distance in the height direction, the sample processing tank (3) is a cuboid, and the focusing acoustic lenses (1) are arranged on the inner sides of the long side walls of the sample processing tank (3) and extend along the long side walls;
the ultrasonic transducers (2) are ultrasonic transducer array, are arranged on the outer side of the side wall of the sample processing groove (3) and are arranged along the extending direction of the focusing acoustic lens (1), and the ultrasonic transducers (2) on the same side of the sample processing groove (3) have the same height; the ultrasonic transducers (2) on the two sides of the sample processing groove (3) are not oppositely and symmetrically arranged, but are arranged in a staggered manner in the horizontal direction, the ultrasonic transducers are staggered or spaced at a set distance, and the working voltage of the ultrasonic transducers is non-same-frequency excitation voltage;
the excitation frequencies of the two focusing acoustic lenses (1) are different.
2. The ultrasonic processor of claim 1, wherein the focal positions of the focusing acoustic lenses (1) coincide.
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| CN202010197515.0A CN111944670B (en) | 2020-03-19 | 2020-03-19 | Ultrasonic processor |
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| CN202010197515.0A CN111944670B (en) | 2020-03-19 | 2020-03-19 | Ultrasonic processor |
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| CN111944670B true CN111944670B (en) | 2021-11-30 |
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| CN1836769A (en) * | 2005-03-23 | 2006-09-27 | 深圳职业技术学院 | Energy conversion method and device for ultrasonic liquid processing |
| CN101140354A (en) * | 2006-09-04 | 2008-03-12 | 重庆融海超声医学工程研究中心有限公司 | Resonant vibration type supersonic transducer |
| US20150094590A1 (en) * | 2013-09-30 | 2015-04-02 | Seiko Epson Corporation | Ultrasonic device, ultrasonic probe, electronic equipment, and ultrasonic image device |
| CN107402154A (en) * | 2017-09-18 | 2017-11-28 | 中国地质科学院郑州矿产综合利用研究所 | Automatic change magnetism solid phase extraction device |
| CN109431543A (en) * | 2018-12-20 | 2019-03-08 | 深圳先进技术研究院 | Sound wave condenser lens, supersonic imaging device and method |
| CN109718924A (en) * | 2019-02-01 | 2019-05-07 | 无锡比朗实验仪器制造有限公司 | Non-contact ultrasonic is crushed instrument |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2479346C1 (en) * | 2011-08-29 | 2013-04-20 | Андрей Александрович Геталов | Method of simultaneous ultrasound cavitation processing of different-composition media |
| RU2501598C1 (en) * | 2012-05-21 | 2013-12-20 | Андрей Александрович Геталов | Method of simultaneous ultrasonic cavitation processing of liquid medium volumes |
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2020
- 2020-03-19 CN CN202010197515.0A patent/CN111944670B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1836769A (en) * | 2005-03-23 | 2006-09-27 | 深圳职业技术学院 | Energy conversion method and device for ultrasonic liquid processing |
| CN101140354A (en) * | 2006-09-04 | 2008-03-12 | 重庆融海超声医学工程研究中心有限公司 | Resonant vibration type supersonic transducer |
| US20150094590A1 (en) * | 2013-09-30 | 2015-04-02 | Seiko Epson Corporation | Ultrasonic device, ultrasonic probe, electronic equipment, and ultrasonic image device |
| CN107402154A (en) * | 2017-09-18 | 2017-11-28 | 中国地质科学院郑州矿产综合利用研究所 | Automatic change magnetism solid phase extraction device |
| CN109431543A (en) * | 2018-12-20 | 2019-03-08 | 深圳先进技术研究院 | Sound wave condenser lens, supersonic imaging device and method |
| CN109718924A (en) * | 2019-02-01 | 2019-05-07 | 无锡比朗实验仪器制造有限公司 | Non-contact ultrasonic is crushed instrument |
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Denomination of invention: Ultrasonic processor Granted publication date: 20211130 Pledgee: Zhuhai Branch of China Construction Bank Co.,Ltd. Pledgor: ZHUHAI APPLETREE BIOTECHNOLOGY CO.,LTD. Registration number: Y2024980013033 |