CN111939354B

CN111939354B - Acid-base regulating fluid for dialysate regeneration and dialysate regeneration method

Info

Publication number: CN111939354B
Application number: CN202010750732.8A
Authority: CN
Inventors: 李建中; 胡悦琛; 刘自军
Original assignee: Research Center for Eco Environmental Sciences of CAS
Current assignee: Research Center for Eco Environmental Sciences of CAS
Priority date: 2020-07-30
Filing date: 2020-07-30
Publication date: 2022-05-10
Anticipated expiration: 2040-07-30
Also published as: CN111939354A

Abstract

The invention provides an acid-base regulating fluid for dialysate regeneration and a dialysate regeneration method. The acid-base regulating solution for dialysate regeneration provided by the embodiment of the invention adopts an aqueous solution containing sodium carbonate and sodium hydroxide instead of the traditional sodium bicarbonate solution, so that the acid-base balance of the regenerated dialysate can be regulated, the bicarbonate ion concentration and the carbon dioxide partial pressure are controlled within a reasonable range, the dialysis quality is ensured, and the control unit of an instrument is simplified.

Description

Acid-base regulating fluid for dialysate regeneration and dialysate regeneration method

Technical Field

The invention relates to the field of hemodialysis, in particular to an acid-base regulating solution for dialysate regeneration and a dialysate regeneration method.

Background

The acid-base balance, the ionic balance and the bicarbonate concentration of the dialysate have a significant impact on the quality of the dialysis. Wherein, the bicarbonate radical is an important component in human tissue fluid and has important significance for maintaining the acid-base balance of the body. Serum HCO₃ ^-Is an important buffer system in plasma, is also an important index for judging the acid-base imbalance in vivo, and plays an important role in treating respiratory acidosis and chronic respiratory alkalosis. A low bicarbonate concentration can cause acidosis in the patient and a high bicarbonate concentration can cause alkalosis, posing a large risk to the health of the patient. In the hemodialysis process, the control of the concentration of bicarbonate in dialysate and the adjustment of acid-base balance of blood are important roles in dialysis treatment. In the traditional dialysis process, the concentration of bicarbonate radical in the dialysate can be accurately controlled to be 30-40mM by controlling the proportion of the A liquid (ion regulating liquid), the B liquid (acid-base regulating liquid) and water.

However, during dialysis based on a dialysate regeneration cycle, the acid-base balance and bicarbonate concentration of the regenerated dialysate are affected by various factors, and the fluctuation is large. For example, the Sorbent system is a widely used dialysate regeneration system, and the adsorption column mainly comprises zirconium anion and cation exchange resin, urease, activated carbon and other materials. After the dialysate flows through the adsorption column, various cations in the dialysate are exchanged with zirconium cation resin, and H is released⁺With bicarbonate radical to form CO₂Resulting in a decrease in bicarbonate concentration of the dialysate. However, when urea in the dialysate is decomposed by urease, ammonium carbonate is generated, and the generated ammonium carbonate reacts with the adsorption column to generate a large amount of bicarbonate, resulting in a higher concentration of bicarbonate in the dialysate. Meanwhile, in order to adjust the acid-base of the regenerated dialysate to a reasonable range, the B liquid is generally required to be added to neutralize the acid generated by the adsorption column. Tradition ofDuring the dialysis process, sodium bicarbonate solution is used as solution B. In the dialysate regeneration process, if sodium bicarbonate is used as the B liquid to adjust the pH of the dialysate, excessive bicarbonate ions can be introduced, a large amount of carbon dioxide is generated, the concentration of bicarbonate and the partial pressure of carbon dioxide in the dialysate exceed a reasonable range, the health of a patient is affected, a degassing device is usually needed to remove excessive carbon dioxide, and the acid-base balance of the dialysate is difficult to adjust. Similar problems are encountered in other dialysate regeneration circulation systems in addition to the sorbent system.

Disclosure of Invention

The embodiment of the invention provides an acid-base regulating fluid for dialysate regeneration and a dialysate regeneration method, which are used for overcoming the defect of overlarge fluctuation of the concentration of bicarbonate ions in regenerated dialysate in the prior art, realizing effective regulation of acid-base balance of the regenerated dialysate, and controlling the concentration of the bicarbonate ions and the partial pressure of carbon dioxide within a reasonable range.

The embodiment of the invention provides an acid-base regulating fluid for dialysate regeneration, which is an aqueous solution containing sodium carbonate and sodium hydroxide.

According to the acid-base regulating solution for dialysate regeneration provided by the embodiment of the invention, the mass percentage of sodium carbonate is 0.1-10%, and the mass percentage of sodium hydroxide is 0.1-5%.

More preferably, the mass percent of the sodium carbonate is 1.2-6%, and the mass percent of the sodium hydroxide is 1-2%.

The embodiment of the invention also provides a dialysate regeneration method, which adopts any one of the acid-base regulating solutions for dialysate regeneration to regulate the acid-base balance of the regenerated dialysate.

According to the dialysate regeneration method provided by the embodiment of the invention, after the dialysate is exchanged with blood, the dialysate flows through an adsorption column for regeneration, then the acid-base regulating fluid is added to regulate the acid-base balance of the regenerated dialysate, the bicarbonate ion concentration and the carbon dioxide partial pressure of the regenerated dialysate are controlled within a reasonable range, and then the A fluid is added to regulate the ion balance of the regenerated dialysate.

According to the regeneration method of the dialysate provided by the embodiment of the invention, the total concentration of sodium ions in the dialysate is 120-145 mM, and the concentration of bicarbonate ions is 0-60 mM.

According to the dialysate regeneration method provided by the embodiment of the invention, the A liquid is composed of an electrolyte containing potassium, calcium and magnesium, and is used for adjusting the concentration of potassium, calcium and magnesium ions in the regenerated dialysate and providing chloride ions to the regenerated dialysate.

According to the dialysate regeneration method provided by the embodiment of the invention, the adsorption column contains activated carbon, anion-cation exchange resin and urease material or urea adsorption material, wherein the cation exchange resin releases H after absorbing cations⁺And Na⁺The anion exchange resin removes harmful anions from the dialysate and adjusts the pH of the dialysate.

According to the dialysate regeneration method provided by the embodiment of the invention, the cation exchange resin is sodium zirconium phosphate, the anion exchange resin is hydrous zirconium oxide, the ratio of the two is 15: 1-3: 1, and the pH value of the adsorption column is 5.7-6.5;

or the cation exchange resin is sodium zirconium phosphate, the anion exchange resin is hydrous zirconium oxide and zirconium carbonate, and the pH value of the adsorption column is 5.7-6.5.

The embodiment of the invention also provides application of any one of the acid-base regulating solution for dialysate regeneration or the dialysate regeneration method in blood purification and peritoneal dialysis.

The acid-base regulating fluid for dialysate regeneration provided by the embodiment of the invention adopts an aqueous solution containing sodium carbonate and sodium hydroxide instead of the traditional sodium bicarbonate solution, so that the acid-base balance of the regenerated dialysate can be regulated, the concentration of bicarbonate ions and the partial pressure of carbon dioxide are controlled within a reasonable range, the dialysis quality is ensured, and the control unit of an instrument is simplified.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and those skilled in the art can also obtain other drawings according to the drawings without creative efforts.

FIG. 1 is a schematic diagram of a dialysate regeneration system according to an embodiment of the present invention;

FIG. 2 is a graph showing the results of the change in the concentration of bicarbonate ions and the partial pressure of carbon dioxide with time in the regenerated dialysate of example 1 in accordance with the present invention;

FIG. 3 is a graph of the concentration of bicarbonate ions and pH as a function of time in the regenerated dialysate of example 1 in accordance with the present invention;

FIG. 4 is a graph showing the results of the concentration of bicarbonate ions and the partial pressure of carbon dioxide in the regenerated dialysate of example 2 in accordance with the present invention as a function of time;

FIG. 5 is a graph of the concentration of bicarbonate ions and pH as a function of time in regenerated dialysate of example 2 in accordance with the present invention;

FIG. 6 is a graph showing the results of the concentration of bicarbonate ions and the partial pressure of carbon dioxide in the regenerated dialysate of example 3 in accordance with the present invention as a function of time;

FIG. 7 is a graph of the concentration of bicarbonate ions and pH as a function of time in regenerated dialysate according to example 3 of the present invention;

FIG. 8 is a graph showing the results of the concentration of bicarbonate ions and pH as a function of time in the regenerated dialysate of comparative example 1 according to the present invention;

FIG. 9 is a graph showing the results of the change in the concentration of bicarbonate ions and the partial pressure of carbon dioxide with time in the regenerated dialysate of comparative example 2 according to the present invention;

FIG. 10 is a graph showing the results of the concentration of bicarbonate ions and the partial pressure of carbon dioxide in the regenerated dialysate of comparative example 3 according to the present invention as a function of time;

FIG. 11 is a graph showing the results of the change in the concentration of bicarbonate ion and the partial pressure of carbon dioxide with time in the regenerated dialysate of comparative example 4 according to the present invention.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In traditional dialysis process, adopt the sodium bicarbonate solution to be acid-base regulating solution, can introduce excessive bicarbonate ion like this at the dialysate regeneration in-process to produce a large amount of carbon dioxide and lead to bicarbonate concentration and carbon dioxide partial pressure in the dialysate to exceed reasonable scope, influence patient's health, generally need adopt degasser, remove excessive carbon dioxide, lead to the difficult regulation and control of acid-base balance of dialysate. In order to solve this problem, it is generally conceivable to increase the pH of the adsorption column and reduce the acidity, but this reduces the adsorption capacity of the adsorption column for harmful cations (ammonium ions) and increases the dialysis risk. Through a large number of experiments, the invention discovers that the acid-base balance (pH of 7.1-7.3) of the regenerated dialysate can be more effectively adjusted by adding the aqueous solution containing sodium carbonate and sodium hydroxide, and the bicarbonate ion concentration (30-40 mM) and the carbon dioxide partial pressure (<110mmHg) are controlled within a reasonable range.

Further, the sodium carbonate accounts for 0.1-10% by mass, and the sodium hydroxide accounts for 0.1-5% by mass.

More preferably, the mass percent of the sodium carbonate is 1.2-6%, and the mass percent of the sodium hydroxide is 1-2%. For example, the acid-base adjusting solution may be an aqueous solution of 6% sodium carbonate + 1% sodium hydroxide, an aqueous solution of 2% sodium carbonate + 1% sodium hydroxide, or an aqueous solution of 1.2% sodium carbonate + 2% sodium hydroxide.

The embodiment of the invention also provides a dialysate regeneration method, and the acid-base balance of the regenerated dialysate is adjusted by adopting any one of the acid-base adjusting solutions for dialysate regeneration.

In one embodiment of the invention, the dialysate regeneration method comprises the steps of exchanging dialysate with blood, flowing through an adsorption column for regeneration, adding the acid-base adjusting liquid to adjust the acid-base balance of the regenerated dialysate, controlling the bicarbonate ion concentration and the carbon dioxide partial pressure of the regenerated dialysate within a reasonable range, and adding the liquid A to adjust the ion balance of the regenerated dialysate.

Wherein the total concentration of sodium ions in the dialysate is 120-145 mM, and the concentration of bicarbonate ions is 0-60 mM.

The A liquid is composed of electrolyte containing potassium, calcium and magnesium, and is used for adjusting the concentration of potassium, calcium and magnesium ions in the regenerated dialysis liquid and providing chloride ions to the dialysis liquid.

The adsorption column contains active carbon, anion and cation exchange resin and urease material or urea adsorption material, wherein the cation exchange resin releases H after absorbing cations⁺And Na⁺The anion exchange resin removes harmful anions from the dialysate and adjusts the pH of the dialysate.

In a preferred embodiment of the invention, the cation exchange resin is sodium zirconium phosphate, the anion exchange resin is hydrous zirconium oxide, the ratio of the two is 15: 1-3: 1, and the pH of the adsorption column is 5.7-6.5.

In another preferred embodiment of the present invention, the cation exchange resin is sodium zirconium phosphate, the anion exchange resin is hydrous zirconium oxide and zirconium carbonate, and the pH of the adsorption column is 5.7 to 6.5.

Based on the embodiment, in the process of regenerating the dialysate, the flow rate of the dialysate is 10-1000mL/min, the blood flow rate is 10-500mL/min, the adding speed of the A liquid is 0.1-50mL/min, and the adding speed of the acid-base regulating liquid is 0-50 mL/min.

In a preferred embodiment of the invention, the pH of the regenerated dialysate is detected by a pH electrode, and the addition amount of the acid-base regulating solution is fed back and regulated in real time, so that the pH is controlled within a set range;

detecting the conductivity of the regenerated dialysate through a conductive electrode, indirectly testing the concentration of sodium ions, feeding back and adjusting the addition amount of the acid-base adjusting liquid in real time, and controlling the ion concentration of the solution within a set range;

and (3) adjusting the pH set value of the dialysate (adjusted within the range of 7.1-7.3) or diluting when the concentration is higher through on-line bicarbonate ion detection result feedback.

The embodiment of the invention also provides application of the acid-base regulating solution or the dialysate regeneration method in blood purification and peritoneal dialysis.

The following examples illustrate specific solutions or reagents used in the following examples as follows:

dialyzate: 103.0mmol/L of sodium chloride, 38.0mmol/L of sodium bicarbonate and 3.0mmol/L of acetic acid;

solution A: 83.4mmol/L of potassium chloride, 61.2mmol/L of calcium chloride and 37.6mmol/L of magnesium chloride;

simulation liquid: 4.9g A powder (NaCl: 4.42g, KCl: 0.11g, CaCl) is dissolved in 1L water₂·2H₂O：0.162g、MgCl₂·6H₂0.08g of O and acetic acid: 0.13g) +2.94g B powder (sodium bicarbonate);

the adsorption column comprises: 1300g of sodium zirconium phosphate, 400g of zirconium oxide, 15000UI of immobilized urease and 500g of activated carbon.

Example 1: the solution B (acid-base regulating solution) is aqueous solution of 6% sodium carbonate and 1% sodium hydroxide

A simulated dialysate regeneration cycle test was performed using a dialysate regeneration system as shown in figure 1. The method comprises the following specific steps:

4L of simulation solution is taken, 8g of urea is added into the simulation solution, the simulation solution is stirred uniformly, the simulation solution is placed at the arterial blood end 1 to simulate arterial blood, the simulation solution flows into an arterial pot 2 through a blood pump, the flow rate of the blood pump is set to be 150mL/min, urea solution (150mg/mL, the total amount is 100mL) is continuously supplemented into the arterial pot 2 from an inlet 3, and the flow rate of a peristaltic pump is set to be 0.5 mL/min.

From the arterial pot 2, the blood flows into the dialyzer 4 where it exchanges substances with the dialysate at a flow rate of 300mL/min, and the exchanged blood then flows into the venous pot 5, passes through the gas detector 6 and returns to the venous blood end 7.

After being exchanged with blood, the dialysate flows out through a blood leakage detector 8, flows through an adsorption column 9 under the action of a power pump, a supplementary B liquid 10 is subjected to acid-base regulation and then returns to a buffer tank 11 to be mixed and then flows out, an ion detection module 12 is arranged on an outflow pipeline, so that the addition amount of the A liquid 13 is adaptively adjusted, after ion balance is regulated, regeneration is achieved, after passing through a filter 14 and a temperature detection device 15, qualified regenerated dialysate enters a dialyzer 4 and is exchanged with the blood, and unqualified regenerated dialysate returns to pass through the adsorption column 9 again and is subjected to subsequent treatment.

A heating system 16 and a blending device 17 are arranged in the buffer tank 11, and a pH sensor 18, a conductivity sensor 19, a liquid level sensor 20 and a temperature sensor 21 are also arranged in the buffer tank 11, so that each index of the blended liquid in the buffer tank 11 can be measured in real time by the sensors, and timely adjustment is facilitated;

a physiological saline 22 and deionized water 23 supplementing pipeline is also arranged on a pipeline for returning the dialysate flowing out from the adsorption column 9 to the buffer tank 11, and is used for adjusting the concentration of the dialysate as required.

The entire dialysis treatment session was 240 minutes.

A dialysate inlet sample is taken, and a blood gas analyzer (Redomide, ABL80) is adopted to test the partial pressure change of bicarbonate ions and carbon dioxide.

As shown in FIGS. 2 and 3, it can be seen that when the aqueous solution of 1% sodium hydroxide and 6% sodium carbonate is used as the solution B, the pH of the dialysate can be adjusted to a predetermined range (7.1 to 7.3), the concentration of bicarbonate ion in the dialysate can be controlled to a reasonable range (30 to 40mM), the partial pressure of carbon dioxide can be maintained in a normal range, and the partial pressure of carbon dioxide can be reduced, which is suitable for pH adjustment and bicarbonate ion concentration control for regeneration of the dialysate.

Example 2: the solution B is 2% sodium carbonate and 1% sodium hydroxide aqueous solution

A simulated dialysate regeneration cycle test was performed using the same procedure as in example 1, except that:

4L of the simulated solution is taken, 8g of urea is added into the simulated solution, the mixture is stirred evenly and is placed at the arterial blood end. The blood pump flow rate is set to be 200mL/min, the dialysate flow rate is set to be 300mL/min, and the treatment lasts for 240 minutes. After initiation of treatment, the blood ends were continuously supplemented with urea solution (150mg/mL, 100mL total) at a flow rate of 0.5mL/min using a peristaltic pump. A dialysate inlet sample is taken, and a blood gas analyzer (Redomide, ABL80) is adopted to test the partial pressure change of bicarbonate ions and carbon dioxide.

As shown in FIGS. 4 and 5, it can be seen that when the aqueous solution of 1% sodium hydroxide and 2% sodium carbonate is used as the solution B, the pH of the dialysate can be controlled within a predetermined range (7.1 to 7.3), the bicarbonate ion concentration in the dialysate can be controlled within a reasonable range (30 to 40mM), the carbon dioxide partial pressure can be maintained within a normal range, and the pH adjustment and bicarbonate ion concentration control for regeneration of the dialysate can be suitably performed, and the carbon dioxide partial pressure can be reduced.

Example 3: the solution B is an aqueous solution of 1.2 percent of sodium carbonate and 2 percent of sodium hydroxide

4L of the simulated solution is taken, 8g of urea is added into the simulated solution, the mixture is stirred evenly and placed at the blood end. The blood pump flow rate is set to be 200mL/min, the dialysate flow rate is set to be 300mL/min, and the treatment lasts for 240 minutes. After initiation of treatment, the blood ends were continuously supplemented with urea solution (150mg/mL, 100mL total) at a flow rate of 0.5mL/min using a peristaltic pump. A dialysate inlet sample is taken, and a blood gas analyzer (Redomide, ABL80) is adopted to test the partial pressure change of bicarbonate ions and carbon dioxide.

As shown in FIGS. 6 and 7, it can be seen that when the aqueous solution of 2% sodium hydroxide and 1.2% sodium carbonate is used as the solution B, the pH of the dialysate can be controlled within a predetermined range (7.1 to 7.3), the bicarbonate ion concentration in the dialysate can be controlled within a reasonable range (30 to 40mM), the carbon dioxide partial pressure can be maintained within a normal range, and the pH adjustment and bicarbonate ion concentration control for regeneration of the dialysate can be suitably performed, and the carbon dioxide partial pressure can be reduced.

Comparative example 1: the solution B is 7.5% sodium bicarbonate solution

1L of the simulated solution is taken, 1.5g of urea is added into the simulated solution, the mixture is stirred evenly and placed at the blood end. Setting the flow rate of the blood pump to be 50mL/min and the flow rate of the dialysate to be 100mL/min, and treating for 210 minutes. After initiation of treatment, the blood ends were continuously supplemented with urea solution (125mg/mL, total 80mL) at a flow rate of 0.5mL/min using a peristaltic pump and pH changes in the dialysate were recorded. A sample of the dialysate inlet was taken and the bicarbonate ion change was tested using a blood gas analyzer (Redomide, ABL 80).

As shown in FIG. 8, it can be seen that when a 7.5% pure sodium bicarbonate solution was used as solution B, the pH of the dialysate could not be adjusted to the normal range (7.1 to 7.3), and the partial pressure of carbon dioxide exceeded the value measured by the instrument, the bicarbonate ion exceeded the reasonable range, and the need for adjusting the pH and bicarbonate ion concentration of the regenerated dialysate could not be met.

Comparative example 2: the solution B is aqueous solution of 3.5% sodium bicarbonate and 3.5% sodium carbonate

1L of the simulated solution is taken, 1.5g of urea is added into the simulated solution, the mixture is stirred evenly and placed at the blood end. Setting the flow rate of a blood pump to be 50mL/min and the flow rate of dialysate to be 100mL/min, and treating for 120 minutes. After initiation of treatment, the blood ends were continuously supplemented with urea solution (125mg/mL, total 80mL) at a flow rate of 0.5mL/min using a peristaltic pump. And taking a dialysate inlet sample, and testing the partial pressure change of the bicarbonate ions and the carbon dioxide.

As shown in FIG. 9, it can be seen that when the aqueous solution of 3.5% sodium bicarbonate and 3.5% sodium carbonate was used as solution B, the pH of the dialysate was adjusted to a predetermined range (7.1 to 7.3), but the concentration of bicarbonate ions in the dialysate rapidly exceeded a reasonable range (30 to 40mM), the partial pressure of carbon dioxide was high, and the amount of degassed dialysate load was large beyond the measurement range after 1 hour of operation.

Comparative example 3: the solution B is 5% sodium carbonate solution

1L of the simulated solution is taken, 1.5g of urea is added into the simulated solution, the mixture is stirred evenly and placed at the blood end. The flow rate of the blood pump is set to be 100mL/min, the flow rate of the dialysate is set to be 100mL/min, and the treatment time is set to be 180 minutes. After initiation of treatment, the blood ends were continuously supplemented with urea solution (125mg/mL, total 80mL) at a flow rate of 0.5mL/min using a peristaltic pump. A dialysate inlet sample is taken, and a blood gas analyzer (Redomide, ABL80) is adopted to test the partial pressure change of bicarbonate ions and carbon dioxide.

As shown in FIG. 10, it can be seen that when 5% sodium carbonate solution was used as solution B, the pH of the dialysate was adjusted to a predetermined range (7.1 to 7.3), but the concentration of bicarbonate ions in the dialysate rapidly exceeded a reasonable range (30 to 40mM), the partial pressure of carbon dioxide was high, and the amount of degassed dialysate load was large beyond the measurement range after 2 hours of operation.

Comparative example 4: the solution B is 0.5 percent sodium hydroxide solution

As shown in FIG. 11, it can be seen that when sodium hydroxide solution containing no sodium carbonate is used as solution B, the pH of the dialysate can be controlled within a predetermined range (7.1 to 7.3), and the partial pressure of carbon dioxide can be controlled within a reasonable range, but the concentration of bicarbonate ions in the dialysate is low.

Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.

Claims

1. An acid-base conditioning fluid for use in dialysate regeneration is characterized by being an aqueous solution of sodium carbonate and sodium hydroxide;

the mass percentage of the sodium carbonate is 1.2-6%, and the mass percentage of the sodium hydroxide is 1-2%;

the acid-base regulating solution regulates the acid-base balance of the regenerated dialysate and controls the bicarbonate ion concentration and the carbon dioxide partial pressure of the regenerated dialysate within a reasonable range.

2. A method for regenerating a dialysate, comprising adjusting an acid-base balance of a regenerated dialysate using the acid-base adjusting solution of claim 1.

3. The dialysate regeneration method according to claim 2, comprising exchanging dialysate with blood, flowing through an adsorption column for regeneration, adding the acid-base adjusting solution to adjust the acid-base balance of the regenerated dialysate, controlling the bicarbonate ion concentration and the carbon dioxide partial pressure of the regenerated dialysate within reasonable ranges, and adding liquid A to adjust the ion balance of the regenerated dialysate.

4. The method for regenerating a dialysate according to claim 3, wherein the total concentration of sodium ions in the dialysate is 120 to 145mM, and the concentration of bicarbonate ions is 0 to 60 mM.

5. The method of claim 3, wherein the fluid A is comprised of an electrolyte containing potassium, calcium, and magnesium for adjusting the concentration of potassium, calcium, and magnesium ions in the regenerated dialysate and providing chloride ions to the regenerated dialysate.

6. The dialysate regeneration method according to any one of claims 3 to 5, wherein the adsorption column comprises activated carbon, cation and anion exchange resin, and urease material or urea adsorption material, wherein the cation exchange resin releases H after absorbing cations⁺And Na⁺Anion exchange resin removal from dialysateAnd adjusting the pH of the dialysate.

7. The method for regenerating dialysate according to claim 6, wherein the cation exchange resin is sodium zirconium phosphate, the anion exchange resin is hydrous zirconium oxide, the ratio of the two is 15:1 to 3:1, and the pH of the adsorption column is 5.7 to 6.5;

8. Use of the acid-base modifying solution for dialysate regeneration process according to claim 1 or the method for regenerating dialysate according to any one of claims 2 to 7 for blood purification and peritoneal dialysis.