CN111939170A - Aqueous solution for repairing and nursing skin injury and preparation method thereof - Google Patents

Aqueous solution for repairing and nursing skin injury and preparation method thereof Download PDF

Info

Publication number
CN111939170A
CN111939170A CN202010900888.XA CN202010900888A CN111939170A CN 111939170 A CN111939170 A CN 111939170A CN 202010900888 A CN202010900888 A CN 202010900888A CN 111939170 A CN111939170 A CN 111939170A
Authority
CN
China
Prior art keywords
solution
aqueous solution
water
sodium hyaluronate
care
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202010900888.XA
Other languages
Chinese (zh)
Inventor
蒙虎
黄岸
蒙一纯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Mengborun Biotechnology Co ltd
Original Assignee
Beijing Mengborun Biotechnology Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Mengborun Biotechnology Co ltd filed Critical Beijing Mengborun Biotechnology Co ltd
Priority to CN202010900888.XA priority Critical patent/CN111939170A/en
Publication of CN111939170A publication Critical patent/CN111939170A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to an aqueous solution for repairing and nursing skin injury and a preparation method thereof. Comprises sodium hyaluronate, Cannabidiol (CBD), cosurfactant, solvent and water, and is prepared into an aqueous solution for repairing and nursing skin injury according to a certain proportion. The invention can be prepared by the following method: firstly, dissolving sodium hyaluronate and cosurfactant in water to form solution A, and mixing cannabidiol and solvent according to a certain proportion to form solution B. And then mixing the solution A and the solution B, adjusting the pH value to 5.0-8.0, supplementing the balance of water, and uniformly stirring. The aqueous solution disclosed by the invention has the effects of resisting bacteria, diminishing inflammation, repairing, resisting oxidation and the like on skin, and has the advantages of no adverse reaction, no stimulation, skin moistening and the like.

Description

Aqueous solution for repairing and nursing skin injury and preparation method thereof
Technical Field
The invention belongs to the field of medical dressing and skin care, and particularly relates to an aqueous solution for repairing and caring skin injury and a preparation method thereof
Background
The skin is an organ covering the human body, which prevents the invasion of harmful substances from the outside, maintains the stability of the internal environment of the human body, and protects various tissues and organs in the body from physical, mechanical, chemical and pathogenic microorganisms, thus having a barrier function. However, factors such as deterioration of ecological environment cause the skin to contact polluted air, water environment, pollutants and the like, and the skin is metabolized in a severe environment, so that the skin is damaged to various degrees. Broken skin can lead to bacterial infections. In addition, the turnover rate of the human stratum corneum becomes slower with age, and at the same time, the lipid synthesis capacity of keratinocytes is decreased, and the cell division, growth and differentiation efficiency in the epidermis is decreased. The barrier function of the stratum corneum tends to decrease due to the lack of moisturizing factors and lipids in the skin. When the moisture content of the stratum corneum is below a certain level, the skin loses elasticity, wrinkles and appears dry, and skin aging is accelerated. With the rapid development of economy, people need an aqueous solution product which has the effects of resisting bacteria, diminishing inflammation, repairing, resisting oxidation and the like on skin, has no adverse reaction, has no stimulation, moistens the skin and the like.
Hyaluronic acid is an acidic mucopolysaccharide widely existing in human skin, is formed by repeatedly connecting (1-beta-4) D-glucuronic acid and (1-beta-3) N-acetyl-D-glucosamine disaccharide units, has good physical and chemical properties, and is high in degreeViscoelasticity, plasticity and biocompatibility, and is a bioabsorbable material, has no side effect, and has functions of maintaining the stability of skin tissue and keeping the elasticity of skin. Hyaluronic acid is capable of absorbing and binding a large number of water molecules, has hydrophilicity, and is called an ideal natural moisturizing factor. In addition, hyaluronic acid is a multifunctional matrix in the body and has many important physiological functions, such as regulating proteins, assisting in the diffusion and transportation of water electrolytes, lubricating joints, regulating the permeability of blood vessel walls, and promoting wound healing[1,2]。
Cannabidiol (CBD) is a non-addictive active ingredient in cannabis extract, can repair free radical damage caused by ultraviolet rays, environmental pollutants or other sources, and has the functions of relieving skin and maintaining the optimal state of skin after being absorbed by the skin. CBDs inhibit sebaceous secretion and proliferation of sebaceous gland cells, production of a variety of proinflammatory cytokines, and also inhibit immune cell proliferation, activation, maturation, migration, and antigen presentation, and have been shown to have cell cycle and immune cell modulating, antioxidant, anti-inflammatory, and damaged cell repairing effects. Therefore, the composition has good treatment potential in the aspect of inflammatory dermatosis[3-7]. In addition, a certain concentration of CBD has antibacterial activity against gram-positive bacteria (such as Staphylococcus aureus, Streptococcus, etc.), gram-negative bacteria (such as Escherichia coli, etc.), and mold and yeast[8-10]。
However, CBD is fat-soluble and has poor water solubility, and is not easy to be absorbed by human bodies, so that the bioavailability is low, the transdermal absorption is poor, and the drug effect cannot achieve the expected effect. A certain amount of CBD solvent is added into the aqueous solution for repairing and nursing the skin injury, so that the CBD can be dissolved and uniformly mixed in the aqueous solution. Meanwhile, the added cosurfactant can reduce the surface tension of an interfacial film and form a low-viscosity and relatively uniform solution system in a certain proportion. The CBD is fully dispersed in the system, so that the bioavailability of the CBD can be improved, and the problems of poor transdermal absorption and the like can be better solved.
Disclosure of Invention
The invention aims to solve the problems in the prior art and provides an aqueous solution for repairing and nursing skin injury and a preparation method thereof. The invention comprises sodium hyaluronate, Cannabidiol (CBD), a cosurfactant, a solvent and water. The aqueous solution contains no antiseptic, has effects of resisting bacteria and inflammation, repairing and resisting oxidation, and has advantages of no adverse reaction, no irritation, and moistening skin.
The invention is realized by the following technical scheme: an aqueous solution for repairing and nursing skin injury is characterized by comprising the following components in percentage by mass:
Figure BDA0002659736180000021
the content of the sodium hyaluronate is 0.2-1.2%, and the molecular weight of the sodium hyaluronate is 5000 Da-100 ten thousand Da.
The content of the cosurfactant is 0.01-10.0%.
The cosurfactant includes but is not limited to glycerin, polyethylene glycol, propylene glycol and sorbitol.
The content of CBD is 0.5 ppm-0.1%,
the content of the solvent is 0.5-10%.
The solvent is one or more of alcohols, dichloropentacylines and sulfoxides.
The alcohols include but are not limited to ethanol, the dichloropentane ring includes but is not limited to formaldehyde-condensed glycerol, and the sulfoxides include but are not limited to dimethyl sulfoxide.
The preparation method of the aqueous solution for repairing and nursing the skin injury is characterized by comprising the following steps: the method comprises the following steps:
(1) weighing a certain amount of sodium hyaluronate and cosurfactant according to the mass percentage requirement, adding the sodium hyaluronate and the cosurfactant into water, fully stirring, standing to ensure that the sodium hyaluronate is fully swelled in the water, and obtaining solution A;
(2) weighing a certain amount of CBD and a certain amount of solvent according to the mass percentage requirements of the CBD and the solvent, and uniformly mixing to obtain a solution B;
(3) and adding the solution A into the solution B, mixing and stirring for a certain time to fully and uniformly mix the solution A and the solution B, and adjusting the pH value to 5.0-8.0. The remaining amount of water was added and stirred well to form an aqueous solution.
Detailed Description
The invention is further illustrated by the following specific examples, which are not to be construed as limiting the invention.
Example 1
An aqueous solution for repairing and nursing skin injury comprises the following raw and auxiliary materials in parts by mass: 1.2 percent of sodium hyaluronate with the molecular weight of 5000Da, 10.0 percent of glycerin, 0.1 percent of CBD, 10.0 percent of dimethyl sulfoxide and the balance of water.
An aqueous solution for repairing and caring skin injury, which comprises the following steps:
(1) weighing the components according to the mass percent of the raw and auxiliary materials, sequentially adding 1.2 percent of sodium hyaluronate and 10.0 percent of glycerin into water, fully stirring, and then standing to ensure that the sodium hyaluronate is fully swelled in the water solution and the solution is uniform to obtain solution A;
(2) mixing 0.1% CBD with 10.0% dimethyl sulfoxide and homogenizing to obtain solution B;
(3) and adding the solution A into the solution B, mixing and stirring for a certain time to fully and uniformly mix the solution A and the solution B, and adjusting the pH value to 5.0-8.0. The remaining amount of water was added and stirred well to form an aqueous solution.
Example 2
An aqueous solution for repairing and nursing skin injury comprises the following raw and auxiliary materials in parts by mass: 0.2 percent of sodium hyaluronate with the molecular weight of 100 ten thousand Da, 0.01 percent of polyethylene glycol, 0.5ppm of CBD, 0.5 percent of dimethyl sulfoxide and the balance of water.
An aqueous solution for repairing and caring skin injury, which comprises the following steps:
(1) weighing the components according to the mass percent of the raw and auxiliary materials, sequentially adding 0.2 percent of sodium hyaluronate and 0.01 percent of polyethylene glycol into water, fully stirring, and then standing to ensure that the sodium hyaluronate is fully swelled in the water solution and the solution is uniform to obtain solution A;
(2) mixing 0.5ppm CBD with 0.5% dimethyl sulfoxide and homogenizing to obtain solution B;
(3) and adding the solution A into the solution B, mixing and stirring for a certain time to fully and uniformly mix the solution A and the solution B, and adjusting the pH value to 5.0-8.0. The remaining amount of water was added and stirred well to form an aqueous solution.
Example 3
An aqueous solution for repairing and nursing skin injury comprises the following raw and auxiliary materials in parts by mass: 0.8 percent of sodium hyaluronate with molecular weight of 8000Da, 5.0 percent of glycerin, 100ppm of CBD, 5.0 percent of dimethyl sulfoxide and the balance of water.
An aqueous solution for repairing and caring skin injury, which comprises the following steps:
(1) weighing the components according to the mass percent of the raw and auxiliary materials, sequentially adding 0.8 percent of sodium hyaluronate and 5.0 percent of glycerin into water, fully stirring, and then standing to ensure that the sodium hyaluronate is fully swelled in the water solution and the solution is uniform to obtain solution A;
(2) mixing 100ppm CBD with 5.0% dimethyl sulfoxide and homogenizing to obtain solution B;
(3) and adding the solution A into the solution B, mixing and stirring for a certain time to fully and uniformly mix the solution A and the solution B, and adjusting the pH value to 5.0-8.0. The remaining amount of water was added and stirred well to form an aqueous solution.
Example 4
An aqueous solution for repairing and nursing skin injury comprises the following raw and auxiliary materials in parts by mass: 0.4 percent of sodium hyaluronate with the molecular weight of 10 ten thousand Da, 1.0 percent of glycerin, 5ppm of CBD, 1.0 percent of dimethyl sulfoxide and the balance of water.
An aqueous solution for repairing and caring skin injury, which comprises the following steps:
(1) weighing the components according to the mass percent of the raw and auxiliary materials, sequentially adding 0.4 percent of sodium hyaluronate and 1.0 percent of glycerin into water, fully stirring, and then standing to ensure that the sodium hyaluronate is fully swelled in the water solution and the solution is uniform to obtain solution A;
(2) mixing 5ppm CBD with 1.0% dimethyl sulfoxide and homogenizing to obtain solution B;
(3) and adding the solution A into the solution B, mixing and stirring for a certain time to fully and uniformly mix the solution A and the solution B, adding a pH value regulator, and regulating the pH value to 5.0-8.0. The remaining amount of water was added and stirred well to form an aqueous solution.
Example 5
An aqueous solution for repairing and nursing skin injury comprises the following raw and auxiliary materials in parts by mass: 1.0 percent of sodium hyaluronate with the molecular weight of 1 ten thousand Da, 0.2 percent of glycerin, 50ppm of CBD, 2.0 percent of dimethyl sulfoxide and the balance of water.
An aqueous solution for repairing and caring skin injury, which comprises the following steps:
(1) weighing the components according to the mass percent of the raw and auxiliary materials, sequentially adding 1.0 percent of sodium hyaluronate and 0.2 percent of glycerin into water, fully stirring, and then standing to ensure that the sodium hyaluronate is fully swelled in the water solution and the solution is uniform to obtain solution A;
(2) mixing 50ppm CBD with 2.0% dimethyl sulfoxide and homogenizing to obtain solution B;
(3) and adding the solution A into the solution B, mixing and stirring for a certain time to fully and uniformly mix the solution A and the solution B, and adjusting the pH value to 5.0-8.0. The remaining amount of water was added and stirred well to form an aqueous solution.
Example 6
An aqueous solution for repairing and nursing skin injury comprises the following raw and auxiliary materials in parts by mass: 0.7 percent of hyaluronic acid sodium salt with the molecular weight of 9000Da, 0.5 percent of glycerin, 0.01 percent of CBD, 3.0 percent of dimethyl sulfoxide and the balance of water.
An aqueous solution for repairing and caring skin injury, which comprises the following steps:
(1) weighing the components according to the mass percent of the raw and auxiliary materials, sequentially adding 0.7 percent of sodium hyaluronate and 0.5 percent of glycerin into water, fully stirring, and then standing to ensure that the sodium hyaluronate is fully swelled in the water solution and the solution is uniform to obtain solution A;
(2) mixing 0.01% CBD and 3.0% dimethyl sulfoxide and homogenizing to obtain solution B;
(3) and adding the solution A into the solution B, mixing and stirring for a certain time to fully and uniformly mix the solution A and the solution B, and adjusting the pH value to 5.0-8.0. The remaining amount of water was added and stirred well to form an aqueous solution.
Evaluation of antibacterial Properties
The invention is used for the microbiological examination of the product through the following experiments:
detection indexes are as follows:
microbiological indicator Standard requirements
Total number of colonies (CFU/ml) ≤1000
Total number of mold and yeast (CFU/ml) ≤100
Thermotolerant coliform bacteria/ml Cannot be detected
Staphylococcus aureus/ml Cannot be detected
Pseudomonas aeruginosa/ml Cannot be detected
And (3) detection results:
Figure BDA0002659736180000061
the detection result of the microorganism shows that all indexes of the skin-care product meet the requirements of technical standards for cosmetic safety, and the skin-care product has good antibacterial effect.
Reference to the literature
[1] The study progress of hyaluronic acid [ J ]. school report of Changchun university of science (Nature science edition), 2011,34(3): 101-.
[2]Weissmann B,Meyer K.The structure of hyalobiuronic acid and of hyaluronic acid from umbilical cord[J].JAm Chem Soc,1954,76(7):1753-1757.
[3] Lichaihei, Haodan, Jianjiang, Cannabis diol, research progress in dermatology [ J ]. J.China J.dermatosis, 2019,33(10): 1202-.
[4]Giacoppo S,Galuppo M,Pollastro F,et al.A new formulation of cannabidiol in cream shows therapeutic effects in a mouse model of experimental autoimmune encephalomyelitis[J].Daru,2015,23:48.
[5]Oláh A,Tóth BI,BorbíróI,et al.Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes[J].J Clin Invest,2014,124(9): 3713-3724.
[6]Chelliah MP,Zinn Z,Khuu P,et al.Self-initiated use oftopical cannabidiol oil for epidermolysis bullosa[J].Pediatr Dermatol,2018,35(4):224-227.
[7]Schrader NHB,Duipmans JC,Molenbuur B,et al.Combined tetrahydrocannabinol and cannabidiol to treat pain in epidermolysis bullosa:a report of three cases[J].Br J Dermatol,2019,18(4):922-924.
[8]Appendino G,Gibbons S,Giana A,et al.Antibacterial Cannabinoids from Cannabis sativa:A Structure-Activity Study[J].Journal of Natural Products,2008, 71(8):1427-1430.
[9]Wassmann C S,Hjrup P,Klitgaard J K.Cannabidiol is an effective helper compound in combination with bacitracin to kill Gram-positive bacteria[J].entific Reports,2020,10(1).
[10]Klahn P.Cannabinoids-Promising Antimicrobial Drugs or Intoxicants with Benefits[J].Antibiotics,2020,9(6):297。

Claims (9)

1. An aqueous solution for repairing and nursing skin injury and a preparation method thereof are characterized in that: the skin-care agent comprises sodium hyaluronate, Cannabidiol (CBD), cosurfactant, solvent and water, and the mass percentages of the components are as follows:
Figure FDA0002659736170000011
the balance of water.
2. An aqueous solution for the repair and care of skin lesions according to claim 1, characterized in that: the content of the sodium hyaluronate is 0.2-1.2%, and the molecular weight of the sodium hyaluronate is 5000 Da-100 ten thousand Da.
3. An aqueous solution for the repair and care of skin lesions according to claim 1, characterized in that: the content of the cosurfactant is 0.01-10.0%.
4. An aqueous solution for the repair and care of skin lesions according to claim 1, characterized in that: the cosurfactant includes but is not limited to glycerin, polyethylene glycol, propylene glycol and sorbitol.
5. An aqueous solution for the repair and care of skin lesions according to claim 1, characterized in that: the CBD content is 0.5 ppm-0.1%.
6. An aqueous solution for the repair and care of skin lesions according to claim 1, characterized in that: the content of the solvent is 0.5-10%.
7. An aqueous solution for the repair and care of skin lesions according to claim 1, characterized in that: the solvent is one or more of alcohols, dichloropentacylines and sulfoxides.
8. An aqueous solution for the repair and care of skin lesions according to claim 7, characterized in that: the alcohols include but are not limited to ethanol, the dichloropentane ring includes but is not limited to formaldehyde-condensed glycerol, and the sulfoxides include but are not limited to dimethyl sulfoxide.
9. An aqueous solution for the repair and care of skin lesions according to claim 1, characterized in that: the method comprises the following steps:
(1) weighing a certain amount of sodium hyaluronate and cosurfactant according to the mass percentage requirement, adding the sodium hyaluronate and the cosurfactant into water, fully stirring, standing to ensure that the sodium hyaluronate is fully swelled in the water, and obtaining solution A;
(2) weighing a certain amount of CBD and a certain amount of solvent according to the mass percentage requirements of the CBD and the solvent, and uniformly mixing to obtain a solution B;
(3) and adding the solution A into the solution B, mixing and stirring for a certain time to fully and uniformly mix the solution A and the solution B, and adjusting the pH value to 5.0-8.0. The remaining amount of water was added and stirred well to form an aqueous solution.
CN202010900888.XA 2020-09-01 2020-09-01 Aqueous solution for repairing and nursing skin injury and preparation method thereof Pending CN111939170A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010900888.XA CN111939170A (en) 2020-09-01 2020-09-01 Aqueous solution for repairing and nursing skin injury and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202010900888.XA CN111939170A (en) 2020-09-01 2020-09-01 Aqueous solution for repairing and nursing skin injury and preparation method thereof

Publications (1)

Publication Number Publication Date
CN111939170A true CN111939170A (en) 2020-11-17

Family

ID=73367703

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202010900888.XA Pending CN111939170A (en) 2020-09-01 2020-09-01 Aqueous solution for repairing and nursing skin injury and preparation method thereof

Country Status (1)

Country Link
CN (1) CN111939170A (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107753560A (en) * 2016-12-28 2018-03-06 汉义生物科技（北京）有限公司 A kind of composition and application containing Cannador
CN110840753A (en) * 2019-12-06 2020-02-28 云南绿新生物药业有限公司 Skin lotion containing cannabidiol nanoliposome and preparation method thereof
CN110934757A (en) * 2019-12-25 2020-03-31 湖北楚天香妆生物科技有限公司 Microemulsion rich in cannabidiol

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107753560A (en) * 2016-12-28 2018-03-06 汉义生物科技（北京）有限公司 A kind of composition and application containing Cannador
CN110840753A (en) * 2019-12-06 2020-02-28 云南绿新生物药业有限公司 Skin lotion containing cannabidiol nanoliposome and preparation method thereof
CN110934757A (en) * 2019-12-25 2020-03-31 湖北楚天香妆生物科技有限公司 Microemulsion rich in cannabidiol

Similar Documents

Publication Publication Date Title
CN113332162B (en) protamine-PDRN compound, composition and application in preparation of skin care product
CN106580871B (en) Vaginal gel and preparation method thereof
US20170072024A1 (en) Antimicrobial composition comprising a carbohydrate, glucose oxidase and zinc oxide
CN112603843A (en) Acne-removing additive and application thereof
KR102262466B1 (en) Preservative system comprising lactobacillus acidophilus ferment and antispetic
CN112022795A (en) Skin care and repair composition, preparation method and application thereof
RU2636530C2 (en) Pharmaceutical compositions for treatment of wounds and burns
CN112970787A (en) Anise fennel plant antiseptic and bacteriostatic composition and preparation process and application thereof
CN111939170A (en) Aqueous solution for repairing and nursing skin injury and preparation method thereof
CN111973551A (en) Mussel mucin antibacterial gel and preparation method thereof
CN115624647B (en) Biological film medical dressing compounded with wound healing medicine and film essence, and preparation method and application thereof
CN111728889A (en) A composition containing curcumin, ectoin and madecassoside with synergistic antiinflammatory effect, and its application
EP3352805B1 (en) A novel pharmaceutical wound healing composition
US20140113881A1 (en) Antiinfective composition
CN115919686A (en) Skin soothing lotion for enhancing skin barrier and preparation method thereof
RU2367469C2 (en) Antibacterial and necrolytic local lisoamidase pharmaceutical composition
KR20140145274A (en) Composition for skin moisturizing containing oxygen dissolving water with a polymer composition
CN112007018A (en) Medical cold compress patch for repairing and nursing skin injury and preparation method thereof
CN105169463B (en) A kind of cation baby's medical dressing and preparation method thereof
US20160367605A1 (en) Healing composition and use thereof
JPH08163983A (en) Hyarulonic acid production promoter
CN113456735A (en) Inactivated probiotic herbal gel and preparation method and application thereof
CN111449997A (en) A cosmetic containing chlorella extract as main active ingredient
RU2367456C2 (en) Antibacterial and necrolytic local pharmaceutical composition
US11964041B2 (en) Compositions comprising levan and use thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20201117

WD01 Invention patent application deemed withdrawn after publication