CN111929455B - Sample feeding device for full-automatic chemiluminescence immunoassay analyzer - Google Patents

Sample feeding device for full-automatic chemiluminescence immunoassay analyzer Download PDF

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Publication number
CN111929455B
CN111929455B CN202011029090.9A CN202011029090A CN111929455B CN 111929455 B CN111929455 B CN 111929455B CN 202011029090 A CN202011029090 A CN 202011029090A CN 111929455 B CN111929455 B CN 111929455B
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channel
sample
emergency treatment
rack
emergency
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CN111929455A (en
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柳建敏
陈昊鑫
杨秦天
徐睿
曹宽宽
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Ningbo Haiershi Intelligent Manufacturing Co ltd
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Ningbo Haiyi Biotechnology Co ltd
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584Control arrangements for automatic analysers
    • G01N35/0092Scheduling
    • G01N35/0095Scheduling introducing urgent samples with priority, e.g. Short Turn Around Time Samples [STATS]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76Chemiluminescence; Bioluminescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76Chemiluminescence; Bioluminescence
    • G01N21/763Bioluminescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302Apparatus specially adapted for immunological test procedures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04Details of the conveyor system
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N2021/0106General arrangement of respective parts
    • G01N2021/0112Apparatus in one mechanical, optical or electronic block
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04Details of the conveyor system
    • G01N2035/0401Sample carriers, cuvettes or reaction vessels
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04Details of the conveyor system
    • G01N2035/0439Rotary sample carriers, i.e. carousels
    • G01N2035/0446Combinations of the above

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Abstract

The invention provides a sample introduction device for a full-automatic chemiluminescence immunoassay analyzer, which belongs to the technical field of medical instruments and comprises: the device comprises a rack, a sample collection channel, an emergency treatment channel and a return channel, wherein three channels are arranged on the rack, and are respectively a sample suction channel, an emergency treatment channel and a return channel; the sample detection device comprises a rack, at least one toggle mechanism, a sample suction channel, an emergency treatment channel and a sample collection channel, wherein the rack is provided with a sample collection channel and the emergency treatment channel; and the at least one back-poking mechanism is arranged on the rack and is positioned between the sample sucking channel and the emergency treatment channel, wherein the sample to be detected in the sample sucking channel is introduced into the emergency treatment channel through the back-poking mechanism. Through striking mechanism and dial-back mechanism, realize the double track system for the sample to be examined can make a round trip to shift between emergency call passageway and the sample suction passageway, thereby improves the sample suction efficiency of the sample to be examined, and then improves the detection efficiency of follow-up sample to be examined.

Description

Sample feeding device for full-automatic chemiluminescence immunoassay analyzer
Technical Field
The invention belongs to the technical field of medical instruments, relates to a sample injection device, and particularly relates to a sample injection device for a full-automatic chemiluminescence immunoassay analyzer.
Background
Chemiluminescence immunoassay is a medical inspection instrument for performing immunoassay on a human body by detecting serum of a patient. By combining a chemiluminescence detection technology with high sensitivity and high specificity immunoreaction, the kit can be used for detection and analysis of various antigens, haptens, antibodies, hormones, enzymes, fatty acids, vitamins, medicines and the like.
Chinese patent (CN 109541198B) discloses a sample management system with emergency treatment function, which comprises a loading frame, a divider plate disposed on the bottom plate of the loading frame to divide the loading frame into a loading channel and a loading channel, wherein the outlet end of the loading channel is connected with the inlet end of the loading channel through a sampling line unit; the sampling line unit comprises a first vertical plate, a first synchronous belt transmission mechanism connected with the loading channel and the unloading channel is arranged on the first vertical plate, an emergency sample loading area is formed at the inlet end of a first synchronous belt of the first synchronous belt transmission mechanism, and a sample rack positive and negative sensor and an emergency in-place sensor are arranged on the first vertical plate of the emergency sample loading area at intervals in the front and back; the right side of the first vertical plate is provided with an emergency treatment pushing hand mechanism and a sampling line pushing hand mechanism. The emergency treatment sample loading area is independent of the loading channel and the unloading channel, the emergency treatment sample loading area and the sampling line area are integrated on the first synchronous belt, the emergency treatment sample is simple and convenient to detect, the standby is not needed, and the random emergency treatment of the emergency treatment sample can be realized.
However, the sample management system described above is a monorail system, i.e. only the emergency sample is pushed into the loading channel from the emergency channel for performing the aspiration detection, and has the following problems: in a large number of samples to be detected, some samples to be detected need to be extracted by the sample absorbing equipment on the front station, and some samples to be detected need to be extracted by the sample absorbing equipment on the rear station, if the structure that the loading channel is pushed into the emergency treatment channel does not exist, the samples to be detected which need to be extracted by the sample absorbing equipment on the rear station are always in a waiting state, so that the detection time is prolonged, and the working efficiency is reduced.
Disclosure of Invention
The invention aims to solve the problems in the prior art and provides a sample feeding device with a double-gauge system and high working efficiency.
The purpose of the invention can be realized by the following technical scheme: a kind of sample introduction device used for full-automatic chemiluminescence immunity analyzer, comprising:
the device comprises a rack, a sample collection channel, an emergency treatment channel and a return channel, wherein three channels are arranged on the rack, and are respectively a sample suction channel, an emergency treatment channel and a return channel;
the sample detection device comprises a rack, at least one toggle mechanism, a sample suction channel, an emergency treatment channel and a sample collection channel, wherein the rack is provided with a sample collection channel and the emergency treatment channel;
and the at least one back-poking mechanism is arranged on the rack and is positioned between the sample sucking channel and the emergency treatment channel, wherein the sample to be detected in the sample sucking channel is introduced into the emergency treatment channel through the back-poking mechanism.
In the above sample introduction device for the full-automatic chemiluminescence immunoassay analyzer, the shifting mechanism and the back-shifting mechanism are arranged at intervals.
In the sample introduction device for the full-automatic chemiluminescence immunoassay analyzer, the sample suction channel, the emergency treatment channel and the return channel are arranged in parallel, the sample suction channel and the emergency treatment channel are separated from each other at intervals by the partition board, a plurality of notches are formed in the partition board between the sample suction channel and the emergency treatment channel, and the position of the toggle mechanism and the position of the return mechanism correspond to the positions of the notches respectively.
In the above sample introduction device for the full-automatic chemiluminescence immunoassay analyzer, the sample suction channel, the emergency treatment channel and the return channel are horizontally and transversely arranged, and the turning channel is horizontally and longitudinally arranged, wherein two ends of the turning channel are respectively communicated with the sample suction channel and the return channel, and turning guide plates are arranged at the communication parts of the turning channel and the sample suction channel and the communication parts of the turning channel and the return channel, and guide concave parts are arranged on the inner sides of the turning guide plates.
In the above sample introduction device for the full-automatic chemiluminescence immunoassay analyzer, the toggle mechanism comprises a toggle motor installed on the rack through a connecting plate, and the output end of the toggle motor is connected with a toggle rod through a coupler, wherein the toggle rod is provided with a guide concave part.
In the above sample introduction device for the full-automatic chemiluminescence immunoassay analyzer, the detection structure is mounted on the rack, wherein the detection structure comprises a detection piece mounted on the rack and a rotating piece mounted at the output end of the toggle motor.
In the above sample introduction device for the full-automatic chemiluminescence immunoassay analyzer, a plurality of limiting mechanisms are respectively arranged along the sample suction channel, the emergency treatment channel and the return channel, wherein each limiting mechanism is installed on the rack through a connecting piece.
In the above sample introduction device for the full-automatic chemiluminescence immunoassay analyzer, the limiting mechanism comprises an electromagnetic valve and a built-in electromagnet, and one end of the electromagnet is matched with the limiting rod in a magnetic attraction manner.
In the sample introduction device for the full-automatic chemiluminescence immunoassay analyzer, a plurality of proximity sensors are arranged between the sample suction channel and the emergency treatment channel, wherein the sensing part of one proximity sensor faces the sample suction channel, and the sensing part of the other proximity sensor faces the emergency treatment channel.
In the sample introduction device for the full-automatic chemiluminescence immunoassay analyzer, the proximity sensor with the sensing part facing the sample suction channel and the proximity sensor with the sensing part facing the emergency treatment channel are arranged at intervals.
The invention also provides a sample introduction device for the full-automatic chemiluminescence immunoassay analyzer, which comprises:
the sample sucking and returning device comprises a plurality of racks, a sample sucking channel, an emergency treatment channel and a returning channel, wherein the racks are spliced in a straight line, and each rack is provided with three channels which are respectively a sample sucking channel, an emergency treatment channel and a returning channel, and a steering channel is arranged between the sample sucking channel and the returning channel on a tail rack;
at least one toggle mechanism which is arranged on the frame and is positioned between the sample suction channel and the emergency treatment channel,
and the at least one back-poking mechanism is arranged on the rack and is positioned between the sample sucking channel and the emergency treatment channel, wherein the sample to be detected in the sample sucking channel is introduced into the emergency treatment channel through the back-poking mechanism.
Compared with the prior art, the invention has the beneficial effects that:
(1) according to the sample introduction device for the full-automatic chemiluminescence immunoassay analyzer, a double-track system is realized through the shifting mechanism and the back-shifting mechanism, so that a sample to be detected can be transferred back and forth between the emergency treatment channel and the sample suction channel, the sample suction efficiency of the sample to be detected is improved, and the detection efficiency of subsequent samples to be detected is improved;
(2) the emergency treatment detected sample on the emergency treatment channel can be inserted into the common detected sample in the sample suction channel, a quick channel is provided for an emergency patient, and the optimal detection of the emergency treatment detected sample is realized;
(3) in addition, the two ends of the steering channel are provided with the steering guide plates, and the guide concave parts are arranged on the inner sides of the steering guide plates, so that the reaction cup holder is smoother in the steering process, collision between the reaction cup holder and the inner wall of the channel is avoided, and the safety of conveying the reaction cup holder is improved;
(4) the guide concave part is arranged on the poke rod, so that the poke rod is attached to the surface of the reaction cup saucer containing the emergency examined sample when the emergency examined sample is introduced into the sample sucking channel from the emergency channel, the guide of the emergency examined sample in the moving process is formed, the emergency examined sample is prevented from turning over or bumping in the transferring process, in addition, the emergency examined sample can be prevented from entering the sample sucking channel in advance through the rotation of the poke rod, the collision with the common examined sample in the sample sucking channel is avoided, and the reliability and the safety of the emergency examined sample in the transferring process are improved;
(5) the rotation angle of the poke rod under the action of the poke motor is controlled through the matching between the detection piece and the rotating piece, so that the situation that the poke rod enters the return channel due to an overlarge angle when being opened to influence the normal operation of the return channel is avoided, and meanwhile, the situation that the poke rod enters the sample suction channel due to the overlarge angle when rotating to influence the normal operation of the sample suction channel is avoided;
(6) the sample to be detected, which is required to be extracted by the sample sucking equipment on the rear station, is firstly introduced into the emergency treatment channel by arranging the dial-back mechanism, and the conveying of the sample to be detected is accelerated by utilizing the characteristics of few detected samples, high conveying speed and the like on the emergency treatment channel, so that the working efficiency of the detected sample is ensured;
(7) by arranging the limiting mechanism, on one hand, the samples to be detected are conveyed one by one when conveyed on the corresponding channels, and collision between adjacent detected samples is avoided, on the other hand, when the emergency treatment detected samples are introduced into the sample sucking channel from the emergency treatment channel through the shifting mechanism, or when the common detected samples are introduced into the emergency treatment channel from the sample sucking channel through the back shifting mechanism, collision or interference with the detected samples which are normally conveyed is avoided, and the reliability and safety of the conveying of the detected samples are ensured;
(8) on one hand, the reaction cup saucer for containing a sample to be detected can be sensed through the proximity sensor, information data of the current sample to be detected is read through a chip at the bottom of the reaction cup saucer, and the sample to be detected is judged to be required to be extracted by a sample absorbing device on which station, so that the corresponding shifting mechanism and the back-shifting mechanism are controlled to act; on the other hand, the power on and off of the electromagnetic valve can be controlled, the extension and retraction of the limiting rod are realized, and the one-by-one conveying of the detected samples is ensured.
Drawings
FIG. 1 is a schematic structural diagram of a sample injection device for a full-automatic chemiluminescence immunoassay analyzer.
Fig. 2 is an enlarged view of a portion a in fig. 1.
Fig. 3 is an enlarged view of a portion B in fig. 1.
Fig. 4 is an enlarged view of a portion C in fig. 1.
Fig. 5 is an enlarged view of a portion D in fig. 1.
FIG. 6 is a schematic diagram of another view of the sample injection device for the full-automatic chemiluminescence immunoassay analyzer according to the invention.
Fig. 7 is an enlarged view of a portion E in fig. 6.
FIG. 8 is a schematic view of a partial structure of a sample injection device for a full-automatic chemiluminescence immunoassay analyzer according to the invention.
Fig. 9 is an enlarged view of portion F in fig. 8.
Fig. 10 is an enlarged view of a portion G in fig. 9.
FIG. 11 is a schematic structural diagram of a sample injection device for use in another embodiment of the full-automatic chemiluminescence immunoassay analyzer according to the invention.
Fig. 12 is an enlarged view of a portion H in fig. 11.
In the figure, 100, a rack; 110. a sample suction channel; 120. an emergency treatment channel; 130. a return channel; 140. a diversion channel; 150. a partition plate; 151. a notch; 160. a slot; 170. a steering guide plate; 171. a guide recess; 180. a bevel gear structure; 190. a conveyor belt; 190A, a transmission motor; 190B, a tensioning wheel; 200. a toggle mechanism; 210. a connecting plate; 220. a motor is shifted; 230. a coupling; 240. a poke rod; 241. a guide recess; 250. detecting the structure; 251. a detection member; 252. a rotating member; 300. a test tube; 400. a reaction cup saucer; 500. a dial-back mechanism; 600. a limiting mechanism; 610. an electromagnetic valve; 620. an electromagnet; 630. a limiting rod; 700. a proximity sensor.
Detailed Description
The following are specific embodiments of the present invention and are further described with reference to the drawings, but the present invention is not limited to these embodiments.
Example one
As shown in fig. 1 to 10, the sample injection device for a full-automatic chemiluminescence immunoassay analyzer provided by the invention comprises: the system comprises a rack 100, a sample sucking channel 110, an emergency treatment channel 120 and a return channel 130, wherein a steering channel 140 is arranged between the sample sucking channel 110 and the return channel 130; at least one toggle mechanism 200, which is installed on the rack 100 and located between the sample suction channel 110 and the emergency treatment channel 120, wherein the sample to be tested in the emergency treatment channel 120 is introduced into the sample suction channel 110 through the toggle mechanism 200;
and at least one back-dial mechanism 500, which is installed on the rack 100 and is located between the sample suction channel 110 and the emergency channel 120, wherein the sample to be tested in the sample suction channel is introduced into the emergency channel through the back-dial mechanism 500.
It should be noted that the emergency test sample and the general test sample are collectively referred to as a test sample.
According to the sample introduction device for the full-automatic chemiluminescence immunoassay analyzer, a double-track system is realized through the poking mechanism 200 and the poking-back mechanism 500, so that a sample to be detected can be transferred back and forth between the emergency treatment channel 120 and the sample sucking channel 110, the sample sucking efficiency of the sample to be detected is improved, and the detection efficiency of subsequent samples to be detected is improved.
Preferably, as shown in fig. 1 to 10, the sample suction channel 110, the emergency channel 120 and the return channel 130 are arranged in parallel, and the sample suction channel 110 and the emergency channel 120, and the emergency channel 120 and the return channel 130 are separated by a partition 150, wherein a plurality of notches 151 are provided on the partition 150 between the sample suction channel 110 and the emergency channel 120, and the position of the toggle mechanism 200 corresponds to the position of the notches 151.
Further preferably, a slot 160 is respectively disposed on the sample suction channel 110, the emergency channel 120 and the return channel 130, and the width of the slot 160 is greater than the width of each corresponding channel, wherein the slots 160 on the sample suction channel 110 and the emergency channel 120 are used as feed inlets, and the slots 160 on the return channel 130 are used as discharge outlets.
In this embodiment, the test sample is stored in the test tube 300, the test tube 300 is placed in the cuvette holder 400, the cuvette holder 400 is configured in an inverted T-shaped configuration, and in order to ensure that the cuvette holder 400 can be smoothly placed in and taken out from the corresponding channel, the sample suction channel 110, the emergency treatment channel 120 and the return channel 130 are respectively provided with slots 160, and in addition, a sample suction device (not shown) for extracting the test sample in the test tube 300 is generally installed at one side of the sample suction channel 110, and after the sample in the test tube 300 is completely extracted, the sample enters the return channel 130 through the diversion channel 140, so the slots 160 on the sample suction channel 110 and the emergency treatment channel 120 serve as feed inlets, and the slots 160 on the return channel 130 serve as discharge outlets.
Preferably, as shown in fig. 1 to 10, the sample suction channel 110, the emergency treatment channel 120 and the return channel 130 are horizontally and transversely arranged, the diversion channel 140 is horizontally and longitudinally arranged, wherein both ends of the diversion channel 140 are respectively communicated with the sample suction channel 110 and the return channel 130, and a diversion guide plate 170 is arranged at the communication part of the diversion channel 140 and the sample suction channel 110 and the communication part of the diversion channel 140 and the return channel 130, and a guide concave part 171 is arranged at the inner side of the diversion guide plate 170.
In this embodiment, the bevel gear structure 180 is disposed between the sample suction channel 110 and the turning channel 140, so as to turn the horizontal and lateral moving cuvette holder 400 into the horizontal and longitudinal moving cuvette holder 400, which provides a basis for automatic turning and recycling of the cuvette holder 400, and in addition, the turning guide plates 170 are disposed at two ends of the turning channel 140, and the guide concave portions 171 are disposed at the inner sides of the turning guide plates 170, so that the cuvette holder 400 is smoother in the turning process, collision between the cuvette holder 400 and the inner wall of the channel is avoided, and the safety of transportation of the cuvette holder 400 is improved.
Preferably, as shown in fig. 1 to 10, conveyor belts 190 are disposed in the sample suction passage 110, the emergency treatment passage 120 and the return passage 130, wherein each conveyor belt 190 is driven to rotate circumferentially by a corresponding transmission motor 190A.
Further preferably, since the running direction of the conveyor belt 190 in the sample suction channel 110 is consistent with the running direction of the conveyor belt 190 in the emergency treatment channel 120, the conveyor belt 190 in the sample suction channel 110 and the conveyor belt 190 in the emergency treatment channel 120 share one transmission motor 190A, wherein the conveyor belt 190 in the sample suction channel 110 and the conveyor belt 190 in the emergency treatment channel 120 run synchronously through synchronous pulleys, so as to reduce the number of the transmission motors 190A, on one hand, reduce the number of parts mounted on the rack 100, make the layout of the parts more compact and reasonable, and on the other hand, reduce the production cost of the feeding device.
Preferably, as shown in fig. 1 to 10, the conveying motor 190A is mounted on the frame 100 through a connecting frame, wherein at least one tension wheel 190B is mounted on the frame 100 on the same side as the output end of the conveying motor 190A.
In this embodiment, the tension wheel 190B is provided, so that the conveyor belt 190 is always in a tension state, and the smoothness of the sample to be detected in the conveying process is ensured.
Preferably, as shown in fig. 1 to 10, the toggle mechanism 200 includes a toggle motor 220 mounted on the frame 100 through a connecting plate 210, and an output end of the toggle motor 220 is connected to a toggle rod 240 through a coupling 230, wherein the toggle rod 240 is provided with a guide recess 241.
In this embodiment, the guiding concave portion 241 is disposed on the poke rod 240, so that the poke rod 240 is attached to the surface of the cuvette holder 400 for containing the emergency test sample when the emergency test sample is introduced into the sample suction channel 110 from the emergency channel 120, thereby forming a guide for the emergency test sample during moving, and preventing the emergency test sample from turning over or bumping during transferring, and in addition, the poke rod 240 starts to rotate and completely opens, and will cross the width direction of the entire emergency channel 120, so that if there is a normal test sample in the sample suction channel 110 at the same time when passing through the position of the poke mechanism 200, the rotation of the poke rod 240 can prevent the emergency test sample from entering the sample suction channel 110 in advance, and prevent the normal test sample from colliding with the normal test sample in the sample suction channel 110, and when the normal test sample in the sample suction channel 110 passes through, the poke rod 240 opens again, the emergency test sample is guided to enter the sample sucking channel 110, so that the reliability and the safety of the emergency test sample in the transferring process are improved.
Preferably, as shown in fig. 1 to 10, a detecting structure 250 is mounted on the frame 100, wherein the detecting structure 250 includes a detecting member 251 mounted on the frame 100, and a rotating member 252 mounted on an output end of the toggle motor 220.
In this embodiment, the rotation angle of the poke rod 240 under the action of the poke motor 220 is controlled by the cooperation between the detecting element 251 and the rotating element 252, so as to prevent the poke rod 240 from entering the return channel 130 due to an excessively large angle when being opened, thereby preventing the poke rod 240 from affecting the normal operation of the return channel 130, and meanwhile, prevent the poke rod 240 from entering the sample sucking channel 110 due to an excessively large angle when being rotated, thereby preventing the sample sucking channel 110 from being affected by the normal operation of the sample sucking channel 110.
Further preferably, the detecting member 251 is disposed in a U-shaped structure, wherein a closed end of the U-shaped detecting member 251 is mounted on the frame 100, and an open end of the U-shaped detecting member 251 is inserted into and engaged with the rotating member 252.
In this embodiment, the toggle motor 220 is a stepping motor, when in an initial state, one end of the rotating member 252 is located in the open end of the U-shaped detecting member 251, at this time, the rotating member 252 and the U-shaped detecting member 251 form an "insertion" fit, and then the toggle motor 220 is turned on to drive the toggle rod 240 to rotate and open, when the toggle rod 240 is opened to the position above the partition 150 between the emergency treatment channel 120 and the return channel 130, the toggle motor 220 stops operating, at this time, the toggle rod 240 is in a maximum opening state, at this time, the emergency treatment sample in the emergency treatment channel 120 is introduced into the sample sucking channel 110 under the mutual fit action of the conveyor belt 190 and the guiding concave portion 241 of the toggle rod 240; after the emergency sample is transferred, the poking motor 220 drives the poking rod 240 to rotate, and when the rotating piece 252 is inserted into the open end of the U-shaped detecting piece 251 again, the poking motor 220 stops operating again, and at this time, the poking rod 240 is reset to be completed.
Preferably, as shown in fig. 1 to 10, a back-dialing mechanism 500 is further installed at the gap 151, wherein the general sample to be tested in the sample suction channel 110 can be introduced into the emergency channel 120 through the back-dialing mechanism 500.
In clinical practice, a plurality of sample suction devices are generally installed on one side of the sample suction channel 110 and installed on different stations, wherein some samples to be tested need to be extracted by the sample suction device on the front station and some samples to be tested need to be extracted by the sample suction device on the rear station, in order to improve the working efficiency, the samples to be tested which need to be extracted by the sample suction device on the rear station are firstly introduced into the emergency channel 120 (without affecting the conveyance of the emergency test samples in the emergency channel 120), the conveyance of the samples to be tested is accelerated by utilizing the characteristics of less samples to be tested on the emergency channel 120, high conveying speed and the like, and when the samples to be tested are approaching the corresponding devices, the samples are introduced into the sample suction channel 110 from the emergency channel 120 through the toggle mechanism 200, thereby ensuring the working efficiency of the samples to be tested.
Further preferably, the toggle mechanism 200 is spaced apart from the dial-back mechanism 500.
In the present embodiment, since the structure of the dial-back mechanism 500 is the same as that of the dial mechanism 200, the detailed description thereof is omitted.
Preferably, as shown in fig. 1 to 10, a plurality of limiting mechanisms 600 are respectively disposed along the sample suction passage 110, the emergency treatment passage 120 and the return passage 130, wherein each limiting mechanism 600 is mounted on the rack 100 through a connecting member.
In this embodiment, by providing the limiting mechanism 600, on one hand, it is ensured that the samples to be tested are conveyed one by one when conveyed on the corresponding channels, and collision between adjacent samples to be tested is avoided, and on the other hand, when the emergency test sample is introduced into the sample suction channel 110 from the emergency channel 120 by the toggle mechanism 200, or when the ordinary sample to be tested is introduced into the emergency channel 120 from the sample suction channel 110 by the toggle mechanism 500, collision or interference with the normally conveyed sample to be tested is avoided, and reliability and safety of conveying the samples to be tested are ensured.
Further preferably, the limiting mechanism 600 includes a solenoid valve 610, and an electromagnet 620 is disposed on the solenoid valve 610, wherein one end of the electromagnet 620 is magnetically engaged with the limiting rod 630.
In this embodiment, when the solenoid valve 610 is powered on, the limiting rod 630 is pushed to extend out and enter the corresponding channel, so as to block the movement of the sample to be detected; when the electromagnetic valve 610 is powered off, the limiting rod 630 is pulled to retract, the corresponding channel is withdrawn, the blockage of the detected sample is removed, and the detected sample is conveyed smoothly.
Further preferably, the limiting rod 630 is provided with a U-shaped structure, wherein the closed end of the U-shaped limiting rod 630 is magnetically attracted to the electromagnet 620, and the open end of the U-shaped limiting rod 630 is inserted into the corresponding channel. When the electromagnetic valve 610 is powered on, two sides of the opening end of the U-shaped limiting rod 630 synchronously extend out and extend into two sides of the corresponding channel, two sides of a detected sample are synchronously blocked, and the blocking effect is improved.
Preferably, as shown in fig. 1 to 10, a plurality of proximity sensors 700 are disposed between the pipette channel 110 and the emergency channel 120, wherein a sensing portion of one proximity sensor 700 faces the pipette channel 110, and a sensing portion of the other proximity sensor 700 faces the emergency channel 120.
In this embodiment, on one hand, the proximity sensor 700 can sense the cuvette holder 400 for holding the sample to be tested, and on the other hand, the chip at the bottom of the cuvette holder 400 reads the information of the sample to be tested, and determines which station the sample to be tested needs to be extracted by the sample-sucking device, thereby controlling the corresponding actions of the toggle mechanism 200 and the dial-back mechanism 500; on the other hand, the on-off of the electromagnetic valve 610 can be controlled, the extension and retraction of the limiting rod 630 are realized, and the one-by-one conveying of the detected samples is ensured.
It is further preferred that the proximity sensor 700 with the sensing part facing the sample aspirating channel 110 is spaced apart from the proximity sensor 700 with the sensing part facing the emergency channel 120.
Example two
As shown in fig. 1 to 12, the difference between the first embodiment and the second embodiment is that the sample injection device in the present embodiment includes: a plurality of racks 100, which are spliced in a straight line, and each rack 100 is provided with three channels, namely a sample suction channel 110, an emergency treatment channel 120 and a return channel 130, wherein a steering channel 140 is arranged between the sample suction channel 110 and the return channel 130 on the end rack 100 (corresponding to the position of the initial rack 100); and at least one toggle mechanism 200, which is installed on the rack 100 and is located between the sample suction channel 110 and the emergency channel 120, wherein when the emergency channel 120 has the emergency sample to be tested input, the sample can be quickly introduced into the sample suction channel 110 through the toggle mechanism 200, and the priority detection of the emergency sample to be tested is realized before the ordinary sample to be tested which is sequenced in the sample suction channel 110.
The specific embodiments described herein are merely illustrative of the spirit of the invention. Various modifications or additions may be made to the described embodiments or alternatives may be employed by those skilled in the art without departing from the spirit or ambit of the invention as defined in the appended claims.

Claims (8)

1. A kind of sample introduction device used for full-automatic chemiluminescence immunity analyzer, comprising: the device comprises a rack, a sample sucking channel, an emergency treatment channel and a return channel, wherein three channels are arranged on the rack, and are respectively a sample sucking channel, an emergency treatment channel and a return channel;
the sample detection device comprises a rack, at least one toggle mechanism, a sample suction channel, an emergency treatment channel and a sample collection channel, wherein the rack is provided with a sample collection channel and the emergency treatment channel;
the sample sucking channel is arranged on the frame and is positioned between the sample sucking channel and the emergency treatment channel;
the sample sucking channel, the emergency treatment channel and the return channel are arranged in parallel, and the sample sucking channel and the emergency treatment channel are separated from each other at intervals by a partition plate, wherein a plurality of notches are formed in the partition plate between the sample sucking channel and the emergency treatment channel, and the position of the shifting mechanism and the position of the return mechanism respectively correspond to the positions of the notches;
the poking mechanism comprises a poking motor which is arranged on the rack through a connecting plate, the output end of the poking motor is connected with a poking rod through a coupler, and a guide concave part is arranged on the poking rod.
2. The sample introduction device of claim 1, wherein the toggle mechanism is spaced apart from the return mechanism.
3. The sample introduction device for the full-automatic chemiluminescence immunoassay analyzer according to claim 1, wherein the sample suction channel, the emergency treatment channel and the return channel are horizontally arranged in a transverse direction, the turning channel is horizontally arranged in a longitudinal direction, wherein both ends of the turning channel are respectively communicated with the sample suction channel and the return channel, and a turning guide plate is arranged at the communication part of the turning channel and the sample suction channel and the communication part of the turning channel and the return channel, and a guide concave part is arranged at the inner side of the turning guide plate.
4. The sample introduction device for the full-automatic chemiluminescence immunoassay analyzer according to claim 1, wherein the detection structure is mounted on the frame, wherein the detection structure comprises a detection piece mounted on the frame and a rotation piece mounted at the output end of the toggle motor.
5. The sample introduction device according to claim 1 or 2, wherein a plurality of position-limiting mechanisms are respectively disposed along the sample suction channel, the emergency treatment channel, and the return channel, and each position-limiting mechanism is mounted on the rack through a connecting member, wherein the position-limiting mechanisms comprise electromagnetic valves and built-in electromagnets, and one end of each electromagnet is magnetically engaged with a position-limiting rod.
6. The sample introduction device for the full-automatic chemiluminescence immunoassay analyzer according to claim 5, wherein a plurality of proximity sensors are arranged between the sample suction channel and the emergency treatment channel, wherein the sensing part of one proximity sensor faces the sample suction channel, and the sensing part of the other proximity sensor faces the emergency treatment channel.
7. The sample introduction device for the full-automatic chemiluminescence immunoassay analyzer according to claim 6, wherein the proximity sensor of the sensing part facing the sample suction channel and the proximity sensor of the sensing part facing the emergency treatment channel are arranged at intervals.
8. The utility model provides a sampling device for full-automatic chemiluminescence immunoassay appearance which characterized in that includes:
the sample sucking and returning device comprises a plurality of racks, a sample sucking channel, an emergency treatment channel and a returning channel, wherein the racks are spliced in a straight line, and each rack is provided with three channels which are respectively a sample sucking channel, an emergency treatment channel and a returning channel, and a steering channel is arranged between the sample sucking channel and the returning channel on a tail rack;
at least one toggle mechanism which is arranged on the frame and is positioned between the sample suction channel and the emergency treatment channel,
the sample sucking channel is arranged on the frame and is positioned between the sample sucking channel and the emergency treatment channel;
the sample sucking channel, the emergency treatment channel and the return channel are arranged in parallel, and the sample sucking channel and the emergency treatment channel are separated from each other at intervals by a partition plate, wherein a plurality of notches are formed in the partition plate between the sample sucking channel and the emergency treatment channel, and the position of the shifting mechanism and the position of the return mechanism respectively correspond to the positions of the notches;
the poking mechanism comprises a poking motor which is arranged on the rack through a connecting plate, the output end of the poking motor is connected with a poking rod through a coupler, and a guide concave part is arranged on the poking rod.
CN202011029090.9A 2020-09-27 2020-09-27 Sample feeding device for full-automatic chemiluminescence immunoassay analyzer Active CN111929455B (en)

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JP3839441B2 (en) * 2004-03-22 2006-11-01 株式会社アイディエス Transfer direction changing device for test tube transfer path
ITMI20121293A1 (en) * 2012-07-25 2014-01-26 Inpeco Ip Ltd AUTOMATION MODULE FOR MANUAL INTRODUCTION AND WITHDRAWAL OF BIOLOGICAL SAMPLES TO INTERFACE URGENTLY TO AN ANALYSIS MODULE FOR LABORATORY DIAGNOSTICS.
US9696330B2 (en) * 2012-09-26 2017-07-04 Hitachi High-Technologies Corporation Sample conveyor apparatus and specimen testing automation system
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Application publication date: 20201113

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Denomination of invention: An injection device for automatic chemiluminescence immunoanalyzer

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Address before: 315040 East, 4th floor, building 044, 66 Qingyi Road, high tech Zone, Ningbo City, Zhejiang Province

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