CN111920896A - Application of allium mongolicum regel composition in preparation of products for inhibiting glucosidase activity - Google Patents
Application of allium mongolicum regel composition in preparation of products for inhibiting glucosidase activity Download PDFInfo
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- A61K2236/30—Extraction of the material
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses an application of a garlic allium mongolicum regel composition in preparing a product for inhibiting the activity of glucosidase, wherein the composition comprises the following components in parts by weight: 2.5-20 parts of garlic alcohol extract, 0.5-20 parts of garlic water extract, 0.7-4.3 parts of allium mongolicum regel alcohol extract and 0.5-1 parts of allium mongolicum regel water extract, can effectively inhibit the activity of alpha-glucosaccharase, has the effect of inhibiting the activity better than that of any single extract, and can be used for preparing products for preventing and/or treating diseases taking the alpha-glucosaccharase as a target spot, such as obesity, hypertension, chronic hepatitis B, AIDS, tumors and the like.
Description
Technical Field
The invention belongs to the field of medicines, and particularly relates to an application of a garlic allium mongolicum regel composition in preparation of a product for inhibiting the activity of glucosidase.
Background
Garlic is an underground bulb of a Liliaceae (Liliaceae) Allium (Allium) plant, contains abundant proteins, oligosaccharides and polysaccharides, and also contains fat, mineral substances and the like, can be used as a seasoning, can be used as a medicine, is a famous plant for both food and medicine, can play a role in disease prevention and health care after being eaten for a long time, has various biological activities, and is expected to be used for developing products for preventing or treating various diseases.
Allium mongolicum regel, also called mongolian leek, is a liliaceae allium plant, grows in desert, sandy land or arid hillside with the altitude of 800-2800 meters, and is mainly distributed in Xinjiang (northeast), Qinghai (north), Gansu, Ningxia (north), Shanxi (north), inner Mongolia and Liaoning (west) in China.
Diabetes is a group of metabolic diseases characterized by hyperglycemia. Hyperglycemia is caused by a defect in insulin secretion or an impaired biological action, or both. The chronic hyperglycemia results in chronic damage and dysfunction of various tissues, particularly eyes, kidneys, heart, blood vessels and nerves.
In recent years, with the development of socioeconomic and improvement of living standard of residents of all countries in the world, the incidence and prevalence of type 2 diabetes mellitus are increasing year by year, and diabetes mellitus becomes a major social problem threatening the health of people, thereby drawing attention and attention of governments, health departments and most medical workers of all countries. China is one of the countries with the fastest increase of the prevalence rate of diabetes, the prevalence rate of adult diabetes reaches 11.6%, and the prevalence rate of people in the early stage of diabetes is as high as 50.1%. In addition, diseases such as obesity, hypertension, hyperlipidemia, cardiovascular diseases, chronic hepatitis B, AIDS, tumors, etc. are gradually invading the health of people, and long-term taking of traditional therapeutic drugs can cause side effects on the body of patients, so that the development of safer and more effective drugs from natural plants is urgently needed.
Disclosure of Invention
The invention aims to provide application of a garlic allium mongolicum regel composition in preparing a product for inhibiting the activity of glucosidase, and the garlic allium mongolicum regel composition can be used for treating diabetes, obesity and the like.
The invention provides application of a composition in preparing a product for inhibiting the activity of glucosidase, wherein the composition comprises the following components in parts by weight: 2.5-20 parts of garlic alcohol extract, 0.5-20 parts of garlic water extract, 0.7-4.3 parts of allium mongolicum regel alcohol extract and 0.5-1 part of allium mongolicum regel water extract.
Further, the composition comprises 5-10 parts of garlic alcohol extract, 1-2 parts of garlic water extract, 1.7-2.7 parts of allium mongolicum regel alcohol extract and 0.5 part of allium mongolicum regel water extract.
Further, the composition comprises 5 parts of garlic alcohol extract, 1 part of garlic water extract, 1.7 parts of allium mongolicum regel alcohol extract and 0.5 part of allium mongolicum regel water extract.
Further, the alcohol of the alcohol extract is selected from one or more of methanol, ethanol, butanol and pentanol.
The alcohol of the alcohol extract not only comprises alcohol compounds such as methanol, ethanol, butanol, pentanol and the like or mixed alcohol, but also comprises aqueous solution of alcohol.
In a particular embodiment of the invention, the alcohol is selected from ethanol; further, the aqueous solution of ethanol is 60 to 100% v/v, preferably 70 to 90% v/v, for example, 70%, 80% or 90% ethanol.
In addition, in the extraction process, if the extraction is carried out for more than 2 times, the ethanol concentration in each extraction can be the same or different, for example, garlic is extracted for 3 times, and each extraction is carried out by using 80% ethanol water solution; or extracting Bulbus Allii for 3 times, sequentially extracting with 90% v/v, 80% v/v, and 70% v/v ethanol water solution; or sequentially extracting garlic by 70% v/v, 80% v/v and 90% v/v ethanol water solution; alternatively, garlic is sequentially extracted with 90% v/v, 70% v/v ethanol aqueous solution, and so on.
Extracting Allium mongolicum regel with 80% ethanol water solution for 3 times; or extracting Allium mongolicum regel for 3 times, sequentially extracting with 90% v/v, 80% v/v and 70% v/v ethanol water solution; or, sequentially extracting allium mongolicum regel by 70% v/v, 80% v/v and 90% v/v ethanol water solution; alternatively, allium mongolicum regel is sequentially extracted with 90% v/v, 70% v/v ethanol aqueous solution, and so on.
The extraction method of the invention can adopt the conventional extraction method of natural plant medicines, such as ultrasonic, reflux, decoction, microwave assistance, impregnation and the like.
Further, the product is a product for regulating disturbance of carbohydrate metabolism.
The glycochemical metabolic disorder refers to glycometabolism disorder, and glycometabolism disorder (glucose metabolism disorders) refers to abnormal structure, function and concentration of hormones or enzymes regulating metabolism of glucose, fructose, galactose and the like, or pathophysiological changes of tissues and organs, and blood sugar rise is monitored. It is usually caused by some diseases, obesity, high fat diet, etc., or by structural abnormality, function and concentration abnormality of hormone or enzyme for regulating sugar metabolism caused by congenital factors or pathological changes of tissues and organs.
Glucosidases are one of the important members of the sugar metabolic pathways in organisms. Beta-glucosidase can be involved in cellulose metabolism and various physiological and biochemical pathways, and alpha-glucosidase is more directly involved in the metabolic pathways of starch and glycogen. The abnormal function of the enzyme can cause metabolic diseases, and the enzyme is also the target of action of various medicaments and inhibitors and is used for regulating the carbohydrate chemical metabolism in human bodies. Therefore, the composition can regulate the activity of alpha-glucosidase and further regulate the carbohydrate chemical metabolism in human bodies, and can be used for preparing related products.
Further, the product is a product for reducing postprandial blood glucose.
The composition can slow down the speed of decomposing starch into glucose and reduce and delay the absorption of glucose by small intestine by inhibiting alpha-glucosidase on intestinal mucosa so as to reduce blood sugar, has obvious effect on postprandial hyperglycemia, and can be used for preparing products for reducing postprandial blood sugar.
Further, the product is a product for preventing and/or treating impaired glucose tolerance and/or diabetes and complications thereof.
Impaired glucose regulation, i.e., pre-diabetes, mainly includes Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT). The composition has good inhibition effect on the activity of alpha-glucosidase, can effectively improve impaired glucose regulation, prevent and/or treat impaired glucose tolerance and/or diabetes, can also prevent or improve diabetic complications, and can be used for preparing related products.
Furthermore, the product is a product for preventing and/or treating one or more symptoms of obesity, hypertension, chronic hepatitis B, AIDS and tumors.
Further, the product is a glucosidase inhibitor.
Further, the glucosidase inhibitor is an alpha-glucosidase inhibitor.
The alpha-glucosidase inhibitor does not stimulate the secretion of insulin, and the single use of the medicine does not usually cause hypoglycemia, so that the alpha-glucosidase inhibitor can help reduce the fluctuation of blood sugar, can obviously reduce the probability of cardiovascular diseases of diabetics, and has the most obvious effect of improving myocardial infarction. Is one of the few oral hypoglycemic drugs which can interfere with impaired glucose tolerance. The alpha-glucosidase inhibitor has been reported to have definite curative effect on diabetes, and also has certain curative effect on obesity, chronic hepatitis B, AIDS and tumor.
The invention has the beneficial effects that:
(1) the invention provides application of a series of compositions consisting of garlic alcohol extract, garlic water extract, allium mongolicum regel alcohol extract and allium mongolicum regel water extract in preparing products for inhibiting the activity of glucosidase.
(2) The garlic and the allium mongolicum regel are both daily usable raw materials, and the garlic and the allium mongolicum regel are natural food extracts and have high safety.
Detailed Description
The technical solutions of the present invention are described clearly and completely below, and it is obvious that the described embodiments are some, not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1 preparation of extracts of Allium Sativum and Allium mongolicum
(1) Preparing the garlic alcohol extract: extracting dried Bulbus Allii powder with 90% v/v, 80% v/v, and 70% v/v ethanol under reflux for 3 times, filtering, collecting residue, mixing extractive solutions, recovering ethanol, and drying to obtain Bulbus Allii ethanol extract with an extract rate of 75.13 + -5%.
(2) Preparing garlic aqueous extract: and (2) taking the medicine residues in the step (1), adding water, decocting for 3 times, filtering, combining the filtrates, concentrating and drying to obtain the garlic water extract, wherein the paste yield is about 15.18 +/-2% by determination.
(3) Preparing the allium mongolicum regel alcohol extract: and (3) adding 90% v/v, 80% v/v and 70% v/v ethanol into the dry allium mongolicum regel powder dried to constant weight respectively, performing reflux extraction for 3 times, filtering, reserving dregs, merging extracting solutions, recovering ethanol, and drying to obtain the allium mongolicum regel ethanol extract, wherein the determined extraction rate is about 68.92 +/-5%.
(4) Preparing an allium mongolicum regel aqueous extract: and (2) taking the medicine residues in the step (1), adding water, decocting for 3 times, filtering, combining the filtrates, concentrating and drying to obtain the allium mongolicum regel water extract, wherein the paste yield is about 16.21 +/-2% by determination.
Example 2 Allium mongolicum compositions
And (3) uniformly mixing 5g of the garlic alcohol extract prepared in the example 1, 1g of the garlic water extract, 1.7g of the allium mongolicum regel alcohol extract and 0.5g of the allium mongolicum regel water extract to obtain the composition.
Example 3 Allium mongolicum compositions
Taking 10g of the garlic alcohol extract prepared in the example 1, 2g of the garlic water extract, 1.7g of the allium mongolicum regel alcohol extract and 0.5g of the allium mongolicum regel water extract, and uniformly mixing to obtain the composition.
Example 4 Allium mongolicum compositions
Taking 10g of the garlic alcohol extract prepared in the example 1, 2g of the garlic water extract, 2.7g of the allium mongolicum regel alcohol extract and 0.5g of the allium mongolicum regel water extract, and uniformly mixing to obtain the composition.
EXAMPLE 5 Allium mongolicum and allium mongolicum composition capsules
Taking 5g of the garlic alcohol extract, 1g of the garlic water extract, 1.7g of the allium mongolicum regel alcohol extract and 0.5g of the allium mongolicum regel water extract prepared in the example 1, adding a proper amount of microcrystalline cellulose, uniformly mixing, drying and encapsulating to obtain the capsule of the composition.
Example 6 alpha-glucosidase inhibitory Activity
The extracts in this example were prepared as described in example 1.
Measurement of α -glucosidase inhibitory activity:
the influence of the garlic extract and the allium mongolicum regel extract on the activity of the alpha-glucosidase is determined by adopting a 4-nitrophenol-alpha-D-glucopyranoside (PNPG) colorimetric method. Sequentially adding 50uL of extracts (20mg/mL) with different ratios and 100uL of alpha-glucosaccharase solution (5mg/mL) into a 96-well plate, uniformly mixing, and reacting at 25 ℃ for 10 min; adding 50uLPNPG solution (5mmol/L), and reacting at 37 deg.C for 10 min; finally 50uLNa is added2CO3And (3) mixing the solution (0.67mol/L), measuring the absorbance at the wavelength of 405nm, and calculating the inhibition rate. Acarbose was used as a positive control in this assay to add 100uL of alpha-glucosidase solution (5mg/mL), 50uLPNPG solution (5mmol/L) and 50uLNa to 50uL of phosphate buffer (pH6.8)2CO3The solution (0.67mol/L) served as a control group; to 50uL of phosphate buffer (pH6.8) were added 100uL of an α -glucosidase solution (5mg/mL), 50uL of phosphate buffer and 50uLNa2CO3Solution (0.67mol/L) was used as control blank; adding 50uL of Bulbus Allii extract and Allium mongolicum regelTo the extract (20mg/mL) were added 100uL of an α -glucosidase solution (5mg/mL), 50uL of phosphate buffer and 50uLNa2CO3The solution (0.67mol/L) served as a sample blank. The inhibition rates of the garlic extract and the allium mongolicum regel extract on alpha-glucosidase in different proportions are measured, and the hypoglycemic activity of the allium mongolicum regel extract is evaluated, and the results are shown in table 1.
TABLE 1 inhibition of alpha-glucosidase by different extracts
The alpha-glucosidase inhibitor does not stimulate the secretion of insulin, and the single use of the medicine does not usually cause hypoglycemia, so that the alpha-glucosidase inhibitor can help reduce the fluctuation of blood sugar, can obviously reduce the probability of cardiovascular diseases of diabetics, and has the most obvious effect of improving myocardial infarction. Is one of the few oral hypoglycemic drugs which can interfere with impaired glucose tolerance. The alpha-glucosidase inhibitor has been reported to have definite curative effect on diabetes, and also has certain curative effect on obesity, chronic hepatitis B, AIDS and tumor.
Acarbose is an alpha-glucosidase inhibitor, which can inhibit the activity of various alpha-glucosidase such as maltase, isomaltase, glucoamylase and sucrase, so that the rate of starch decomposition into oligosaccharides such as maltose (disaccharide), maltotriose and dextrin (oligosaccharide) and further glucose decomposition is reduced, and the rate of sucrose decomposition into glucose and fructose is reduced, thereby causing the absorption of glucose in intestinal tract to be slowed down, relieving postprandial hyperglycemia and achieving the effect of reducing blood sugar. Can reduce fasting blood glucose and glycosylated hemoglobin after long-term administration.
As can be seen from the data in Table 1, the garlic alcohol extract, the garlic water extract, the allium mongolicum regel alcohol extract and the allium mongolicum regel water extract all have the inhibition effect on alpha-glucosaccharase, but the inhibition effect is weaker; after the four components are combined, the inhibition effect on alpha-glucosaccharase is stronger than that of any single extract under the same dosage, which shows that the garlic alcohol extract, the garlic water extract, the allium mongolicum regel alcohol extract and the allium mongolicum regel water extract are combined to realize synergistic interaction, so that the inhibition activity of the extracts is improved, wherein the garlic alcohol extract: garlic water extract: the allium mongolicum regel alcohol extract: the allium mongolicum regel aqueous extract has the highest inhibitory activity when the allium mongolicum regel aqueous extract is 5.0:1.0:1.7:0.5, and can be used for preparing products for preventing and/or treating diseases taking alpha-glucosaccharase as a target. The garlic and the allium mongolicum regel are both daily usable raw materials, and the garlic and the allium mongolicum regel are natural food extracts and are high in safety.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by the present specification, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (10)
1. The application of a composition in preparing a product for inhibiting the activity of glucosidase comprises the following components in parts by weight: 2.5-20 parts of garlic alcohol extract, 0.5-20 parts of garlic water extract, 0.7-4.3 parts of allium mongolicum regel alcohol extract and 0.5-1 part of allium mongolicum regel water extract.
2. The use of claim 1, wherein the composition comprises 5-10 parts of garlic alcohol extract, 1-2 parts of garlic water extract, 1.7-2.7 parts of allium mongolicum regel alcohol extract and 0.5 part of allium mongolicum regel water extract.
3. The use of claim 2, wherein the composition comprises 5 parts of alcohol extract of garlic, 1 part of water extract of garlic, 1.7 parts of alcohol extract of allium mongolicum regel and 0.5 part of water extract of allium mongolicum regel.
4. The use according to any one of claims 1 to 3, wherein the alcohol of the alcohol extract is selected from one or more of methanol, ethanol, butanol and pentanol, preferably ethanol; further, the aqueous solution of ethanol is 60 to 100% v/v, preferably 70 to 90% v/v.
5. Use according to any one of claims 1 to 4, wherein the product is a product that regulates disorders of carbohydrate metabolism.
6. Use according to any one of claims 1 to 4, wherein the product is a product for lowering postprandial blood glucose.
7. Use according to any one of claims 1 to 4, wherein the product is a product for the prevention and/or treatment of impaired glucose tolerance and/or diabetes and its complications.
8. The use according to any one of claims 1 to 4, wherein the product is a product for preventing and/or treating one or more of obesity, hypertension, chronic hepatitis B, AIDS and tumors.
9. Use according to any one of claims 1 to 4, wherein the product is a glucosidase inhibitor.
10. Use according to claim 9, characterized in that the glucosidase inhibitor is an alpha-glucosidase inhibitor.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102972817A (en) * | 2011-09-07 | 2013-03-20 | 袁明 | Onion health beverage and production method thereof |
| CN103315286A (en) * | 2012-03-25 | 2013-09-25 | 袁明 | Onion capsules and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102972817A (en) * | 2011-09-07 | 2013-03-20 | 袁明 | Onion health beverage and production method thereof |
| CN103315286A (en) * | 2012-03-25 | 2013-09-25 | 袁明 | Onion capsules and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 王婉愉等: "沙葱水提液体外抗氧化及α-葡萄糖苷酶与胰脂肪酶抑制作用的研究", 《食品研究与开发》 * |
| 钱岳晟等: "大蒜对高血压患者血脂、血糖、 血压作用的临床研究", 《浙江中医学学报》 * |
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