CN111920850A - 一种中药热敷贴及其应用 - Google Patents
一种中药热敷贴及其应用 Download PDFInfo
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- CN111920850A CN111920850A CN202010956414.7A CN202010956414A CN111920850A CN 111920850 A CN111920850 A CN 111920850A CN 202010956414 A CN202010956414 A CN 202010956414A CN 111920850 A CN111920850 A CN 111920850A
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Abstract
本发明提出了一种中药热敷贴，包括发热层和硅胶层，所述发热层设有多层线圈层和铁片；所述硅胶层含有中药组合物或其提取物。本发明具有加快局部气血运行并有温煦功能，改善亚健康；如：痛经、前列腺炎、等，可以舒缓局部拘挛不舒、酸胀疼痛等症状；如：颈、肩、腰、膝盖、腹部、等，具有广阔的应用前景。
Description
技术领域
本发明涉及中药技术领域，具体涉及一种中药热敷贴及其应用。
背景技术
热敷贴，顾名思义即发热的膏药类产品，这一类产品可以持续发热24小时，通过热疗以及药疗共同作用人体。其反应原理为利用发热材料在皮肤微刺激的作用下发生发热反应从而产生热量。热敷贴的持续放热可以促进人体微循环进入良性循环状态，恢复正常的生理机能，从而消除疼痛，治疗疾病。
中医理论“通则不痛，痛则不通”，意即内分泌只有通畅了才能有良好的新陈代谢，也就是通则不痛；如果内分泌等出现淤滞堵塞，就会生病也是就痛。中医内病外治的常用外敷药物已经有上千年的历史。但是现有的中药贴敷袋，在使用时存在很多问题，中药在进行外敷时，如果能够进行一定加热，会大幅提高中药药效，现有的中药贴敷袋均不具有加热功能，无法加热，也就没法充分发挥药效，如果需要进行加热，使用者只能额外准备加热装置，使用不方便，并且普通的中药包功效单一，无法适用于多种症候，且常常使用一次后便无法再次使用，其内涵的大量中药药力还没有释放，就无法再次发热使用，只能丢弃，因此需要研究一种使用方便、可循环使用的中药热敷贴。
有鉴于此，特提出本发明。
发明内容
本发明的目的在于提出一种中药热敷贴及其应用，具有加快局部气血运行并有温煦功能，改善亚健康；如：痛经、前列腺炎、等，可以舒缓局部拘挛不舒、酸胀疼痛等症状；如：颈、肩、腰、膝盖、腹部、等。
本发明的技术方案是这样实现的：
本发明提供一种中药热敷贴，包括发热层和硅胶层，所述发热层设有多层线圈层和铁片，所述多层线圈层内设有线圈，所述线圈与充能芯片连接，所述充能芯片提供电能；所述硅胶层含有中药组合物或其提取物。
作为本发明的进一步改进，所述中药组合物包括以下重量份的原料：当归5-10份、陈艾10-20份、丁香1-5份、红花3-7份、伸筋草2-5份。
作为本发明的进一步改进，所述提取物的制备方法如下：将各组分原料洗净、粉碎后干燥，得到中药粉；将中药粉与水混合后，加热至沸腾，提取2次后，合并提取液，浓缩除水，熬制成浓稠膏，相对密度为2.3-3，制得提取物。
作为本发明的进一步改进，所述中药粉粒径在100目以下；所述中药粉和水的固液比为1：(5-10)g/mL；所述提取时间为第一次5-10h，第二次3-5h。
作为本发明的进一步改进，所述硅胶层的制备方法如下：将20-25wt％的稀硅酸钠、25-30wt％稀硫酸和中药粉或提取物，通过一定压力于20-30℃时由喷头喷出，经混合反应生成多硅酸和硫酸钠，多硅酸钠在酸性条件下不稳定，立即缩聚成硅凝胶，硅凝胶在老化槽中老化35h以上，然后放掉老化槽中的老化水，用非铁质的器具将凝胶割成108mm×108mm×3mm的胶块，进入水洗槽，洗至胶块pH值大于5，烘干，得到硅胶层。
作为本发明的进一步改进，所述压力为2-5MPa；所述中药粉的制备方法为将各组分原料洗净、粉碎后干燥，得到中药粉。
作为本发明的进一步改进，所述中药热敷贴可根据使用部位不同制成颈肩组合包或腹包或腰包或膝包。
作为本发明的进一步改进，所述发热层和硅胶层之间由胶黏剂粘结，所述多层线圈层和铁片之间由胶黏剂粘结。
作为本发明的进一步改进，所述胶黏剂为环氧树脂导热胶。
本发明进一步保护一种上述中药热敷贴在改善人体所贴部位的微循环方面中的应用，优选地，所述所贴部位包括颈椎、腰椎、腹部、肩部、乳腺。
本发明具有如下有益效果：本发明的原理是磁场感应涡流加热。即利用电流通过线圈产生磁场，当磁场内磁力线通过铁片时，磁力线被切割，从而产生无数小涡流，使铁片自身铁原子高速旋转并产生碰撞磨擦生热，从而实现发热；
本发明硅胶的制备反应中，稀硅酸钠和稀硫酸经混合反应生成多硅酸和硫酸钠，其反应方程式如下：
Na2SiO3+H2SO4+H2O→H4SiO4+Na2SO4
多硅酸钠在酸性条件下不稳定，立即缩聚成硅凝胶，方程式如下：
nH4SiO4→nSiO2·mH2O+(n-m)H2O
本发明在硅胶制备的过程中加入提取物或者中药粉直接在稀硅酸钠和稀硫酸混合反应的过程中加入，使得中药粉或提取物能够充分在硅胶层中分布，分布均匀且不易结块，该中药粉和提取物经过加热后能够有效进入人体微循环中；
本发明具有加快局部气血运行并有温煦功能，改善亚健康；如：痛经、前列腺炎、等，可以舒缓局部拘挛不舒、酸胀疼痛等症状；如：颈、肩、腰、膝盖、腹部、等。
附图说明
为了更清楚地说明本发明实施例或现有技术中的技术方案，下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动性的前提下，还可以根据这些附图获得其他的附图。
图1为本发明中药热敷贴的横截面结构示意图；
图2为本发明中药热敷贴的多层线圈层的示意图；
其中，1.硅胶层；2.铁片；3.多层线圈层；4.线圈；5.充能芯片。
具体实施方式
下面将对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例1
中药热敷贴，包括发热层和硅胶层1，所述发热层设有多层线圈层3和铁片2，所述多层线圈层3内设有线圈4，所述线圈4与充能芯片5连接，所述充能芯片5提供电能；所述硅胶层1含有提取物。发热层和硅胶层1之间由胶黏剂粘结，所述多层线圈层3和铁片2之间由胶黏剂粘结。所述胶黏剂为环氧树脂导热胶。
提取物包括以下重量份的原料：当归5份、陈艾10份、丁香1份、红花3份、伸筋草2份。
提取物的制备方法如下：将各组分原料洗净、粉碎后干燥，得到中药粉，粒径在100目以下；将中药粉与水混合，固液比为1：5g/mL，加热至沸腾，提取2次，提取时间为第一次5h，第二次3h，合并提取液，浓缩除水，熬制成浓稠膏，相对密度为2.3，制得提取物。
硅胶层的制备方法如下：将20wt％的稀硅酸钠、25wt％稀硫酸和提取物，通过2MPa压力下于20℃时由喷头喷出，经混合反应生成多硅酸和硫酸钠，多硅酸钠在酸性条件下不稳定，立即缩聚成硅凝胶，硅凝胶在老化槽中老化35h，然后放掉老化槽中的老化水，用非铁质的器具将凝胶割成108mm×108mm×3mm的胶块，进入水洗槽，洗至胶块pH值＝5，烘干，得到硅胶层。
实施例2
中药热敷贴，包括发热层和硅胶层1，所述发热层设有多层线圈层3和铁片2，所述多层线圈层3内设有线圈4，所述线圈4与充能芯片5连接，所述充能芯片5提供电能；所述硅胶层1含有提取物。发热层和硅胶层1之间由胶黏剂粘结，所述多层线圈层3和铁片2之间由胶黏剂粘结。所述胶黏剂为环氧树脂导热胶。
提取物包括以下重量份的原料：当归10份、陈艾20份、丁香5份、红花7份、伸筋草5份。
提取物的制备方法如下：将各组分原料洗净、粉碎后干燥，得到中药粉，粒径在100目以下；将中药粉与水混合，固液比为1：10g/mL，加热至沸腾，提取2次，提取时间为第一次10h，第二次5h，合并提取液，浓缩除水，熬制成浓稠膏，相对密度为2.3-3，制得提取物。
硅胶层的制备方法如下：将25wt％的稀硅酸钠、30wt％稀硫酸和提取物，通过5MPa压力下于30℃时由喷头喷出，经混合反应生成多硅酸和硫酸钠，多硅酸钠在酸性条件下不稳定，立即缩聚成硅凝胶，硅凝胶在老化槽中老化37h，然后放掉老化槽中的老化水，用非铁质的器具将凝胶割成108mm×108mm×3mm的胶块，进入水洗槽，洗至胶块pH值＝6，烘干，得到硅胶层。
实施例3
中药热敷贴，包括发热层和硅胶层1，所述发热层设有多层线圈层3和铁片2，所述多层线圈层3内设有线圈4，所述线圈4与充能芯片5连接，所述充能芯片5提供电能；所述硅胶层1含有中药组合物。发热层和硅胶层1之间由胶黏剂粘结，所述多层线圈层3和铁片2之间由胶黏剂粘结。所述胶黏剂为环氧树脂导热胶。
中药粉包括以下重量份的原料：当归7份、陈艾15份、丁香3份、红花5份、伸筋草3份。中药粉的制备方法为将各组分原料洗净、粉碎后干燥，得到中药粉。
硅胶层的制备方法如下：将22wt％的稀硅酸钠、27wt％稀硫酸和中药粉，通过3.5MPa压力下于25℃时由喷头喷出，经混合反应生成多硅酸和硫酸钠，多硅酸钠在酸性条件下不稳定，立即缩聚成硅凝胶，硅凝胶在老化槽中老化40h，然后放掉老化槽中的老化水，用非铁质的器具将凝胶割成108mm×108mm×3mm的胶块，进入水洗槽，洗至胶块pH值＝6.5，烘干，得到硅胶层。
测试例1
将实施例1-3制得的热敷贴以及市售热敷贴进行皮肤贴敷试验，直接将保护膜去除，贴到腹部肚脐下面位置和颈部的大椎穴部，采用实时温度测量仪测量所贴部位的温度，每个热敷贴测量腹部和颈部的大椎穴部各10组数据，试验者年龄在42-55岁，统计最早达到40-50℃的时间，结果如表1所示。
表1不同组别的温度时间
| 组别 | 腹部 | 大椎穴部 |
| 实施例1 | 1s | 2s |
| 实施例2 | 1s | 2s |
| 实施例3 | 1s | 2s |
| 市售 | 1min | 1min30s |
试验结果表明，本发明热敷贴具有发热快的效果，明显优于对比例。
测试例2对类风湿关节炎的治疗效果
选择临床诊断为类风湿关节炎的患者200例(患者类风湿关节炎诊断标准参照1987年美国风湿协会(ARA)修订的诊断标准)，随机分成4组，每组50例，实施例1-3组和市售组。对疗效的判断标准如下所示：
治愈：临床症状减少≥90％或实验室指标完全恢复正常；
显效：临床症状或实验室指标减少≥60％；
有效：临床症状或实验室指标减少≥30％；
无效：临床症状或实验室指标减少<30％及出现负值。
将热敷贴的外包装撕开，待其发热后敷于疼痛部位，30天为一疗程，坚持使用两个疗程，试验结果如表2所示。
统计学处理：全部数据采用SPSS13.0统计学软件进行统计分析，计量资料用均数±标准差(x±s)表示。两组受试者治疗前后症状评分比较均采用t检验，受试者临床疗效比较采用X检验。
表2
| 组别 | 治愈 | 显效 | 有效 | 无效 |
| 实施例1 | 25 | 15 | 8 | 2 |
| 实施例2 | 27 | 17 | 5 | 1 |
| 实施例3 | 25 | 14 | 10 | 1 |
| 市售 | 15 | 5 | 7 | 23 |
试验结果表明，本发明热敷贴具有温经散寒、活血化瘀、引经通络的作用，可有效治疗类风湿关节炎。
测试例3对乳腺疾病的治疗效果
选择乳腺增生女性患者200例(依据2002年中华中医外科学会乳腺病专员委员会第八次会议通过的《乳腺增生病诊断、辩证计疗效判定标准》)，随机分成4组，每组50例，实施例1-3组和市售组。30天为一疗程，每天使用5小时，坚持使用两个疗程，本发明实施例制得的热敷贴用一贴即可，其他根据发热时间的不同，用不同的贴数，对疗效的判断标准如下所示：
治愈：乳痛计乳腺肿块消失，停药后3个月不复发；
显效：乳痛消失或减轻，重型变为轻型，乳腺肿块缩小≥2/3；
有效：乳痛消失或减轻，中型变为轻型，重型变为中型，乳腺肿块缩小≥1/3，＜2/3；
无效：乳痛未减轻或反而加重，乳腺肿块未缩小或反而增大。
治疗结果如表3所示。
统计学处理：全部数据采用SPSS13.0统计学软件进行统计分析，计量资料用均数±标准差(x±s)表示。两组受试者治疗前后症状评分比较均采用t检验，受试者临床疗效比较采用X检验。
表3
| 组别 | 治愈 | 显效 | 有效 | 无效 |
| 实施例1 | 25 | 15 | 8 | 2 |
| 实施例2 | 27 | 17 | 5 | 1 |
| 实施例3 | 25 | 14 | 10 | 1 |
| 市售 | 15 | 5 | 7 | 23 |
试验结果表明，本发明热敷贴具有温经散寒、活血化瘀、引经通络的作用，可有效治疗乳腺不通引起的疼痛、乳腺肿块等多等症状。
测试例4治疗慢性前列腺炎的效果。
1、试验对象
选择慢性前列腺炎患者120例，所有患者病史、病状、体征和实验室检查均符合前列腺诊断标准。年龄最小22岁，最大52岁；病程最短6个月，最长10年。将所有患者随机分为治疗组和对照组各30例，两组患者的一般资料比较，差异无统计学意义(P＞0.05)，具有可比性。
2、诊断标准
参照《中药新药临床研究指导原则》，表现为不同程度的尿频、尿痛、尿闭、夜尿频多；前列腺触诊：腺体饱满或软硬不均，直肠检查患者有不同程度的前列腺压痛；涂片检查，白细胞＞10个/HP，卵磷脂小体减少或者消失。
3、治疗方法
治疗1-3组：采用本发明实施例1-3中的热敷贴(热敷灵)每次一贴，交替贴敷于神厥穴、中极穴、命门穴，每帖使用10h以上，连续使用7～10d，根据患者症状、体征改善情况观察疗效。
对照组：针刺取穴：中极、次髎、行间、归来、三阴交、施以平补平泄法，留针20～30min，加电针及烤神灯，每天治疗1次，共观察7～10d，根据患者症状、体征改善情况观察疗效。
4、疗效判断标准
参照《中国病症诊断疗效标准》拟定，治愈：自觉症状消失，前列腺液检查正常，记3分。显效：自觉症状基本消失，前列腺液高倍镜下白细胞≤3个，记2分。好转：自觉症状显著减轻，前列腺液高倍镜下白细胞4～6个，记1分。无效：自觉症状及前列腺液检查均无改善，记0分。治愈+显效+好转＝总有效。
5、试验结果
四组患者治疗后症状积分均较治疗前降低，差异均有统计学意义(P＜0.01)，但两组间比较，差异无统计学意义(P＞0.05)。治疗组总有效率为93.3％，高于对照组的76.7％，但两组比较，差异无统计学意义(P＞0.05)。见表4-5。
表4两组治疗前后主要症状积分值(x±s，分)
| 组别 | 例数 | 治疗前 | 治疗后 |
| 治疗1组 | 30 | 5.462±0.778 | 3.245±1.021<sup>**</sup> |
| 治疗2组 | 30 | 5.512±0.821 | 3.125±1.123<sup>**</sup> |
| 治疗3组 | 30 | 5.492±0.801 | 3.053±1.025<sup>**</sup> |
| 对照组 | 30 | 5.502±0.782 | 3.572±1.572<sup>**</sup> |
与治疗前比较，**P＜0.01。
表5两组疗效比较(例)
试验结果表明，本发明热敷贴具有温经散寒、活血化瘀、引经通络的作用，可有效治疗慢性前列腺炎引起的尿频、尿痛、尿闭、夜尿频多等症状。
以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。
Claims (10)
1.一种中药热敷贴，其特征在于，包括发热层和硅胶层，所述发热层设有多层线圈层和铁片，所述多层线圈层内设有线圈，所述线圈与充能芯片连接，所述充能芯片提供电能；所述硅胶层含有中药组合物或其提取物。
2.根据权利要求1所述一种中药热敷贴，其特征在于，所述中药组合物包括以下重量份的原料：当归5-10份、陈艾10-20份、丁香1-5份、红花3-7份、伸筋草2-5份。
3.根据权利要求2所述一种中药热敷贴，其特征在于，所述提取物的制备方法如下：将各组分原料洗净、粉碎后干燥，得到中药粉；将中药粉与水混合后，加热至沸腾，提取2次后，合并提取液，浓缩除水，熬制成浓稠膏，相对密度为2.3-3，制得提取物。
4.根据权利要求3所述一种中药热敷贴，其特征在于，所述中药粉粒径在100目以下；所述中药粉和水的固液比为1：(5-10)g/mL；所述提取时间为第一次5-10h，第二次3-5h。
5.根据权利要求4所述一种中药热敷贴，其特征在于，所述硅胶层的制备方法如下：将20-25wt％的稀硅酸钠、25-30wt％稀硫酸和中药粉或提取物，通过一定压力于20-30℃时由喷头喷出，经混合反应生成多硅酸和硫酸钠，多硅酸钠在酸性条件下不稳定，立即缩聚成硅凝胶，硅凝胶在老化槽中老化35h以上，然后放掉老化槽中的老化水，用非铁质的器具将凝胶割成108mm×108mm×3mm的胶块，进入水洗槽，洗至胶块pH值大于5，烘干，得到硅胶层。
6.根据权利要求5所述一种中药热敷贴，其特征在于，所述压力为2-5MPa；所述中药粉的制备方法为将各组分原料洗净、粉碎后干燥，得到中药粉。
7.根据权利要求1所述一种中药热敷贴，其特征在于，所述中药热敷贴可根据使用部位不同制成颈肩组合包或腹包或腰包或膝包。
8.根据权利要求1所述一种中药热敷贴，其特征在于，所述发热层和硅胶层之间由胶黏剂粘结，所述多层线圈层和铁片之间由胶黏剂粘结。
9.根据权利要求8所述一种中药热敷贴，其特征在于，所述胶黏剂为环氧树脂导热胶。
10.一种如权利要求1-9任一项权利要求所述中药热敷贴在改善人体所贴部位的微循环方面中的应用，优选地，所述所贴部位包括颈椎、腰椎、腹部、肩部、乳腺。
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