CN111903541A - Experimental device for be used for constructing animal depression model - Google Patents
Experimental device for be used for constructing animal depression model Download PDFInfo
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- CN111903541A CN111903541A CN202010564678.8A CN202010564678A CN111903541A CN 111903541 A CN111903541 A CN 111903541A CN 202010564678 A CN202010564678 A CN 202010564678A CN 111903541 A CN111903541 A CN 111903541A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/03—Housing for domestic or laboratory animals
- A01K1/031—Cages for laboratory animals; Cages for measuring metabolism of animals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/035—Devices for use in keeping domestic animals, e.g. fittings in housings or dog beds
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- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- General Health & Medical Sciences (AREA)
- Housing For Livestock And Birds (AREA)
Abstract
The application relates to the technical field of experimental instruments, concretely relates to an experimental apparatus for be used for constructing animal depression model, this experimental apparatus includes: the box body comprises a bottom plate and side plates, the top cover comprises a plurality of longitudinal metal wires, the top cover is erected on one side, far away from the bottom plate, of the side plates, the middle parts of the longitudinal metal wires are of V-shaped structures, and the V-shaped structures of the longitudinal metal wires are sunken towards the inside of the accommodating space; the baffle body is arranged in the accommodating space and is used for dividing the accommodating space into at least two chambers so as to respectively limit the moving ranges of at least two animals to be tested in the corresponding chambers; wherein, the baffle body deviates from the top edge department of base and is equipped with the depressed part, and the depressed part includes end to end's first inclined plane, plane and second inclined plane, and the plane is located between the bottom of the V type structure of two adjacent vertical wire. Through the mode, the problem that the existing experimental device can only be used for a short time and the experimental cost is increased can be solved.
Description
Technical Field
The application relates to the technical field of experimental instruments, in particular to an experimental device for constructing an animal depression model.
Background
Depression is a widely prevalent and complex mental disorder characterized by marked and persistent mood depression, manifested as depressed mood, decreased interest, anhedonia, lack of energy, easy fatigue, retarded thinking, etc. In 2017, the world health organization identified depression as the most common cause of disability and health problems, and more than 3 million people worldwide are currently afflicted with depression. It is expected that depression may be one of the highest risk factors for premature death and incapacity in 2030, which will create a heavy family and social burden. In view of the present research, it is generally accepted that depression is the result of a combination of factors, but the exact etiology and pathogenesis of depression remains unclear.
In the process of researching the occurrence and development rules and prevention and treatment measures of depression, the animal model is a key tool for researching the pathophysiology mechanism of depression, screening antidepressant drugs and researching the action mechanism of drugs. In animal models of depression, rodents are often stimulated by various stress patterns to induce depression-like behavior, including chronic unpredictable stress, tail overhang, forced swimming, foot shock and other models, among others. However, our lives in large families of society, and more acceptance is the stress from society.
Existing experimental devices for simulating chronic social frustration to induce a depressed mood in an animal have certain disadvantages. For example, the cage itself needs to be destroyed, the experimental apparatus is unstable, and the like, so that the experimental apparatus can only be used for a short time, and the experimental cost is increased.
Disclosure of Invention
The application aims to provide an experimental device for constructing an animal depression model, which can solve the problem that the existing experimental device can only be used for a short time and the experimental cost is increased.
In order to solve the technical problem, the application adopts a technical scheme that: an experimental facility for constructing an animal depression model is provided, the experimental facility comprising: the box body comprises a bottom plate and a side plate which is connected with and arranged around the bottom plate, and the side plate and the bottom plate jointly enclose an accommodating space; the top cover comprises a plurality of longitudinal metal wires, the top cover is erected on one side of the side plate, which is far away from the bottom plate, the middle parts of the longitudinal metal wires are of V-shaped structures, and the V-shaped structures of the longitudinal metal wires are sunken towards the inside of the accommodating space; the baffle body is arranged in the accommodating space and is used for dividing the accommodating space into at least two chambers so as to respectively limit the moving ranges of at least two animals to be tested in the corresponding chambers; wherein, the baffle body deviates from the top edge department of base and is equipped with the depressed part, and the depressed part includes end to end's first inclined plane, plane and second inclined plane, and the plane is located between the bottom of the V type structure of two adjacent vertical wire.
The beneficial effect of this application does: being different from the prior art, the application provides an experimental device for constructing an animal depression model, which comprises: the box, top cap and baffle body, the top cap includes many vertical wires, the plane of baffle body's depressed part just is in between the bottom of the V type structure of two adjacent vertical wires, form counter force between the plane of baffle body and two adjacent vertical wires, thereby baffle body steadiness and firm nature have been strengthened, in order to avoid leading to the fact the mutual attack between resident person and the invader because of baffle body is not hard up or the aversion, and simultaneously, experimental apparatus can use for a long time, reduce the experiment cost.
Drawings
FIG. 1 is a block diagram of a first embodiment of the experimental apparatus for constructing animal depression models according to the present application;
FIG. 2 is another block diagram of the first embodiment of the experimental apparatus for constructing animal depression models according to the present application;
FIG. 3 is a block diagram of a second embodiment of the experimental apparatus for constructing animal depression models according to the present application;
FIG. 4 is a block diagram of a third embodiment of the experimental apparatus for constructing animal depression models according to the present application;
FIG. 5 is another block diagram of a third embodiment of the experimental apparatus for constructing animal depression models according to the present application;
FIG. 6 is a block diagram of a fourth embodiment of the experimental apparatus for constructing animal depression model according to the present application.
Detailed Description
In order to make the objects, technical solutions and advantages of the present application more apparent, the present application is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the present application and are not intended to limit the present application. In addition, the technical features mentioned in the embodiments of the present application described below may be combined with each other as long as they do not conflict with each other.
As shown in fig. 1 and 2, in the embodiment of the present application, there is provided an experimental apparatus 100 for constructing an animal depression model, which includes: a box body 11, a top cover 12 and a clapboard body 13.
The box 11 includes a bottom plate 111 and a side plate 112 connected to and surrounding the bottom plate 111, and the side plate 112 and the bottom plate 111 together enclose an accommodating space 110. The bottom plate 111 and the side plate 112 are integrated.
Alternatively, the housing 11 may be made of any transparent material to better observe the movement of the animal to be tested in the housing 11.
The top cover 12 comprises a plurality of longitudinal wires 121, and the top cover 12 is erected on the side of the side plate 112 far away from the bottom plate 111. The partition body 13 is disposed inside the accommodating space 110, and the partition body 13 is configured to divide the accommodating space 110 into at least two chambers, so as to limit the moving ranges of at least two animals to be tested in the corresponding chambers respectively.
Specifically, the box 11 that this application was supporting can select to use the rodent rearging cage that has now in the animal room, as long as guarantee that resident person and invader can be in the middle free activity under the condition of keeping apart, living space is enough, and the uniformity that the box 11 was kept in the same batch of experiment can. The partition body 13 is used to partition the activity space of the occupant and the activity space of the intruder in the cabinet 11.
Optionally, baffle body 13 is transparent baffle body 13 that ya li ke material was made, and wherein, the quality of ya li ke material is lighter, and it is convenient, laborsaving to remove, simultaneously, easily washs, high temperature resistant, the disinfection of being more convenient for. The acryl material has high toughness and wear resistance, so the material is easy to process and can cut and drill. The acrylic material also has high transparency, so that an occupant and an intruder can see each other to form visual interference.
The thickness of the clapboard body 13 is 2-4mm, and the clapboard body 13 made of acrylic material has certain toughness under the thickness, thus meeting the requirement that the clapboard body is not easy to be damaged by the inhabitants with stronger aggressivity.
The middle part of the longitudinal wire 121 is a V-shaped structure 1211, the V-shaped structure 1211 of the longitudinal wire 121 is recessed towards the inside of the accommodating space 110, the V-shaped structure 1211 is used for placing a feeding device, drinking water and grains are only needed to be placed in the feeding device, and rodents can obtain the feed and the drinking water through the feeding device without power supply and control.
Correspondingly, the middle of the upper edge of the partition body 13 facing away from the base 18 is provided with a recess 131, and the recess 131 comprises a first inclined surface 1311, a flat surface 1312 and a second inclined surface 1313 which are connected end to end, and the flat surface 1312 is located between the bottom ends of the V-shaped structures 1211 of two adjacent longitudinal wires 121.
Specifically, the bottom end of the recess 131 of the separator body 13 is designed with a plane 1312 of 15-25mm (e.g. 15mm, 18mm, 20mm or 25mm) width, and the minimum distance between the plane 1312 and the bottom plate 111 is 20-40mm (e.g. 20mm, 25mm, 30mm or 40 mm). It should be noted that the plane 1312 is not completely attached to the bottom end of the V-shaped structure 1211, but is slightly higher than the bottom end of the V-shaped structure 1211, so that the plane 1312 is just between the bottom ends of the V-shaped structures 1211 of two adjacent longitudinal wires 121, and when an occupant or an intruder shakes the top cover 12, a counter force is formed between the plane 1312 of the partition body 13 and the two adjacent longitudinal wires 121, thereby enhancing the stability of the partition body 13.
The maximum separation distance between the projection of the first inclined surface 1311, the second inclined surface 1313 at the side plate 112 and the projection of the V-shaped structure 1211 of the longitudinal wire 121 at the same side plate 112 is less than or equal to 8-12 mm.
Alternatively, in order to limit the range of motion of at least two animals to be tested in the corresponding chambers, other areas of the upper edge of the baffle body 13 may be completely attached to the top cover 12.
In contrast to the prior art, the present application provides an experimental apparatus 100 for constructing an animal depression model, the experimental apparatus 100 comprising: the top cover 12 comprises a plurality of longitudinal wires 121, the plane 1312 of the concave portion 131 of the partition body 13 is just located between the bottom ends of the V-shaped structures 1211 of two adjacent longitudinal wires 121, and a counter force is formed between the plane 1312 of the partition body 13 and the two adjacent longitudinal wires 121, so that the stability and the firmness of the partition body 13 are enhanced, and mutual attack between an occupant and an intruder due to looseness or displacement of the partition body 13 is avoided, meanwhile, the experimental device 100 can be used for a long time, and the experimental cost is reduced.
Referring to fig. 2, the partition plate body 13 is provided with air holes 133, and the diameters of the air holes 133 are 8-12mm, so that the animals to be tested can be stimulated visually, auditorily or olfactorily through the air holes 133.
Specifically, the partition body 13 is uniformly provided with a plurality of ventilation holes 133 with the diameter of 8-12mm (for example, 8mm, 10mm or 12mm), and the ventilation holes 133 have good ventilation performance, so that the occupants and the intruders can smell each other.
Referring to fig. 2, the experimental apparatus 100 further includes: at least two clamping members 14, wherein each clamping member 14 comprises a first clamping plate 141, a second clamping plate (not shown) and a first fixing member 15. The first fixing member 15 may be a screw.
The first clamping plate 141 and the second clamping plate are made of Polyvinyl chloride (PVC) resin, the width of each of the first clamping plate 141 and the second clamping plate is 8-12mm (for example, 8mm, 10mm, or 12mm), and the height of each of the first clamping plate 141 and the second clamping plate is 16-24mm (for example, 16mm, 20mm, or 24 mm).
The two clamping members 14 are used to clamp both ends of the same longitudinal wire 121 of the top cover 12. The lower end of the first clamping plate 141 is fixedly arranged at the upper edge of the partition body 13 departing from the bottom plate 111, the lower end of the second clamping plate is fixedly connected with the first clamping plate 141 through the first fixing piece 15, and the upper end of the first clamping plate 141 and the upper end of the second clamping plate are matched to clamp the longitudinal metal wire 121.
Further, fixing holes are formed in the upper edges of the first clamping plate 141, the second clamping plate and the partition body 13. The first fixing member 15 is inserted into the fixing holes of the first clamping plate 141, the second clamping plate and the partition body 13 to rivet the first clamping plate 141, the second clamping plate and the partition body 13.
Through the above manner, when the top cover 12 covers the box body 11, one of the longitudinal wires 121 is just placed between the first clamping plate 141 and the second clamping plate, the clamping pieces 14 at the two ends of the upper edge of the partition body 13 and the plane 1312 of the concave portion 131 of the partition body 13 jointly form a stable triangular structure, and the longitudinal wire 121 of the top cover 12 is combined to stabilize the upper portion of the partition body 13 and prevent the partition body 13 from shaking.
In another embodiment, two ends of the upper edge of the partition body 13 away from the base 18 are respectively provided with a first clamping seat, and the two first clamping seats and the partition body 13 are of an integrated structure. The upper ends of the two first clamping seats are used for clamping two ends of the same longitudinal wire 121 of the top cover 12.
In this way, when the top cover 12 covers the box body 11, two ends of one of the longitudinal wires 121 are just placed on the two first clamping seats, the first clamping seats at two ends of the upper edge of the partition board body 13 and the plane 1312 of the concave portion 131 of the partition board body 13 jointly form a stable triangular structure, and the longitudinal wire 121 of the top cover 12 is combined to enable the upper portion of the partition board body 13 to be stable and not prone to shake.
In another embodiment, two ends of the upper edge of the partition body 13 away from the base 18 are respectively provided with a second clamping seat, and the two second clamping seats and the partition body 13 are of an integral structure.
Referring to fig. 6, the top cap 12 further includes at least two transverse wires, and the upper ends of the two second clamping seats are respectively used for clamping the two transverse wires 122, wherein the two transverse wires 122 are respectively intersected and fixedly connected with the same longitudinal wire 121.
In this way, when the top cover 12 covers the box body 11, the two transverse wires 122 intersecting with the same longitudinal wire 121 and fixedly connected to the same longitudinal wire 121 are respectively and exactly placed on the two second clamping seats, the second clamping seats at the two ends of the upper edge of the partition board body 13 and the plane 1312 of the concave portion 131 of the partition board body 13 jointly form a stable triangular structure, and the longitudinal wire 121 of the top cover 12 is combined to stabilize the upper portion of the partition board body 13 and prevent the upper portion of the partition board body 13 from shaking.
Referring to fig. 3, the experimental apparatus 100 further includes: a base 18. The base 18 is detachably disposed on the bottom plate 111, a groove 180 is disposed on the base 18, and the groove 180 is a long-strip-shaped groove 180. The partition body 13 is inserted into the groove 180, and two ends of the partition body 13 close to the lower edge of the base 18 are smooth arcs 134, and two ends of the partition body 13 can slide along the groove 180, so that the partition body can be taken out of or put into the groove 180.
Specifically, the groove 180 is used for connecting and fixing the partition body 13, so that the partition body 13 is located at a middle portion of the box 11, and the size of the base 18 can be set according to the size of the bottom plate 111 of the box 11, so that the base 18 is attached to the bottom plate 111 of the box 11. In the experiment, the base 18 was placed on the bottom plate 111 of the case 11, and at the same time, a mat was laid on the base 18, so that the base 18 and the groove 180 could be hidden. The depth of the grooves 180 is 6-12mm (e.g., 6mm, 8mm, 10mm, or 12mm) and the width of the grooves 180 is 2.5-4.5mm (e.g., 2.5mm, 3.5mm, or 4.5 mm).
Referring to fig. 4 and 5, the experimental apparatus 100 further includes: a base 18, a fixing plate 16 and a second fixing member 17. The second fixing member 17 may be a screw.
The base 18 is detachably disposed on the bottom plate 111, the fixing plate 16 is disposed on the base 18, and the fixing plate 16 is fixed on the base 18 by the second fixing member 17. Wherein, the partition body 13 is clamped by the fixing plate 16, and both ends of the partition body 13 near the lower edge of the base 18 are smooth arcs 134, both ends of the partition body 13 can slide along the strip-shaped groove 160, so as to be taken out from or put into the strip-shaped groove 160.
Specifically, the removal of the bottom plate 111 and the fixed plate 16 can be performed by removing the second fixing member 17, and the partition body 13 and the fixed plate 16 can also be freely attached and detached. The groove 160 has a depth of 6 to 12mm (e.g., 6mm, 8mm, 10mm, or 12mm) and the groove 160 has a width of 2.5 to 4.5mm (e.g., 2.5mm, 3.5mm, or 4.5 mm).
Different from the prior art, the application provides an experimental device for constructing an animal depression model, which has the following advantages:
1) the clapboard body is a transparent clapboard body made of acryl material, which is convenient for the two animals to be tested to observe each other so as to stimulate each other visually;
2) the clapboard body is provided with air holes, so that two animals to be tested can smell and visit each other conveniently to stimulate each other in vision, hearing or smell;
3) the diameter of the air holes is limited to 8-12mm, so that two animals to be tested can be prevented from being in direct body contact through the air holes;
4) the thickness of the clapboard body is 2-4mm, the clapboard body is firm and has certain toughness, and a resident with strong aggressivity can be prevented from biting and damaging the edge of the air vent through teeth, so that the air vent is enlarged, and the resident penetrates through the clapboard body to excessively bite or seize the intruder.
5) The plane of the concave part of the clapboard body is just positioned between the bottom ends of the V-shaped structures of the two adjacent longitudinal metal wires, and a counterforce is formed between the plane of the clapboard body and the two adjacent longitudinal metal wires, so that the stability and the firmness of the clapboard body are enhanced, and the mutual attack between an occupant and an intruder caused by the looseness or the displacement of the clapboard body is avoided;
6) the clamping pieces or the clamping seats at two ends of the upper edge of the clapboard body and the plane of the concave part of the clapboard body form a stable triangular structure together, and the upper part of the clapboard body is stable and is not easy to shake by combining the longitudinal metal wire of the top cover;
7) the base is detachably arranged on the bottom plate, and the existing rodent rearing cage in the animal house can be selected as the box body, so that the cost of the experimental device is reduced;
8) the baffle body can freely be connected and dismantled with base or fixed plate, after being convenient for demolish the baffle body, attack partial health contact experiment in former box, improve experimental efficiency.
The experimental apparatus 100 provided in the embodiment of the present application is an experimental method for constructing an animal depression model, and the experimental method exposes a rodent to a Chronic Social Defeat Stress (CSDS) model for 10 days to induce its depression. First, a batch of male rodents with a large age and weight of one month is screened as inhabitants, namely attackers, so that the inhabitants can dominate the battle, and rodents with a small age and weight of one month are invaders, and the inhabitants and the invaders have subordination relations. Then the invader is put into a cage of an inhabitant, and the inhabitant attacks the invader, and the body of the invader is directly contacted for 5-10min every day. The rest of the day separates the occupants from the intruder with the baffle body, co-located in the occupant cage, which allows olfactory, visual, tactile contact, but no physical direct contact. The method is continued until the next attack, and the first day of stress is obtained after the process is completed. And in the later stage, the invader is changed to contact different attackers, and the stress is repeated. The physical contact time of the inhabitants to attack the invaders and the number of days for repeated stress can be adjusted according to the change of experimental modes and experimental animals.
In addition to the screening of attackers, the time of attack contact and the number of repeated stress days, the arrangement of the transparent clapboard body with the air holes is also important in the CSDS experiment process. The relationship is that after the intruder is attacked by the body of the resident, the intruder can watch and smell the intruder mutually to cause psychological deterrence and pressure, and directly influence the behavior development process of the intruder like depression.
The above description is only for the purpose of illustrating embodiments of the present application and is not intended to limit the scope of the present application, and all modifications of equivalent structures and equivalent processes, which are made by the contents of the specification and the drawings of the present application or are directly or indirectly applied to other related technical fields, are also included in the scope of the present application.
Claims (10)
1. An experimental setup for constructing a model of animal depression, characterized in that it comprises:
the box body comprises a bottom plate and a side plate which is connected with and arranged around the bottom plate, and the side plate and the bottom plate jointly enclose an accommodating space;
the top cover comprises a plurality of longitudinal metal wires, the top cover is erected on one side of the side plate, which is far away from the bottom plate, the middle parts of the longitudinal metal wires are of V-shaped structures, and the V-shaped structures of the longitudinal metal wires are sunken towards the inside of the accommodating space;
the baffle body is arranged in the accommodating space and is used for dividing the accommodating space into at least two cavities so as to respectively limit the moving ranges of at least two animals to be tested in the corresponding cavities;
the middle part of the upper edge of the base is provided with a concave part, the concave part comprises a first inclined plane, a plane and a second inclined plane which are connected end to end, and the plane is located between the bottom ends of the V-shaped structures of the two adjacent longitudinal metal wires.
2. The experimental device according to claim 1,
the clapboard body is provided with air holes so that the animals to be tested can mutually stimulate the vision, the hearing or the smell through the air holes;
the diameter of the air holes is 8-12 mm.
3. The experimental device according to claim 1,
the maximum distance between the projection of the first inclined plane and the second inclined plane at the side plate and the projection of the V-shaped structure of the longitudinal metal wire at the same side plate is less than or equal to 8-12 mm;
the length of the plane is 15-25 mm;
the minimum spacing distance between the plane and the base is 20-40 mm.
4. The experimental device according to claim 1,
the baffle body is a transparent baffle body made of an acrylic material, so that the animals to be tested can be visually stimulated by the baffle body.
5. The assay device of claim 1, further comprising: the two clamping pieces are used for clamping two ends of the same longitudinal metal wire of the top cover;
each clamping piece comprises a first clamping plate, a second clamping plate and a first fixing piece, the lower end of the first clamping plate is fixedly arranged at the upper edge of the bottom plate, the partition body deviates from the upper edge of the bottom plate, the lower end of the second clamping plate is fixedly connected with the first clamping plate through the first fixing piece, and the upper end of the first clamping plate is matched with the upper end of the second clamping plate to clamp the longitudinal metal wire.
6. The experimental device according to claim 5,
fixing holes are formed in the upper edges of the first clamping plate, the second clamping plate and the partition plate body;
the first fixing piece penetrates through the first clamping plate, the second clamping plate and the fixing hole in the partition body to rivet the first clamping plate, the second clamping plate and the partition body.
7. The experimental device according to claim 1,
two ends of the upper edge of the partition board body, which are away from the base, are respectively provided with a first clamping seat, and the two first clamping seats and the partition board body are of an integrally formed structure;
the upper ends of the two first clamping seats are used for clamping two ends of the same longitudinal metal wire of the top cover.
8. The experimental device according to claim 1,
two ends of the upper edge of the partition board body, which are away from the base, are respectively provided with a second clamping seat, and the two second clamping seats and the partition board body are of an integrally formed structure;
the top cover further comprises at least two transverse metal wires, the upper ends of the two second clamping seats are used for clamping the two transverse metal wires respectively, and the two transverse metal wires are intersected and fixedly connected with the same longitudinal metal wire respectively.
9. The assay device of claim 1, further comprising:
the base is detachably arranged on the bottom plate;
the base is provided with a groove, the clapboard body is inserted into the groove, the two ends of the clapboard body, which are close to the lower edge of the base, are smooth arcs, and the two ends of the clapboard body can slide along the groove, so that the clapboard body can be taken out of or put into the groove.
10. The assay device of claim 1, further comprising:
the base is detachably arranged on the bottom plate;
the fixing plate is arranged on the base;
the fixing plate is fixed on the base through the second fixing piece;
the partition board body is clamped by the fixing plate, two ends of the partition board body, close to the lower edge of the base, are in smooth arc shapes, and two ends of the partition board body can slide along the strip-shaped groove, so that the partition board body can be taken out of or placed into the strip-shaped groove.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010564678.8A CN111903541B (en) | 2020-06-19 | 2020-06-19 | Experimental device for be used for constructing animal depression model |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010564678.8A CN111903541B (en) | 2020-06-19 | 2020-06-19 | Experimental device for be used for constructing animal depression model |
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| Publication Number | Publication Date |
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| CN111903541A true CN111903541A (en) | 2020-11-10 |
| CN111903541B CN111903541B (en) | 2022-02-18 |
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| CN202010564678.8A Active CN111903541B (en) | 2020-06-19 | 2020-06-19 | Experimental device for be used for constructing animal depression model |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114009354A (en) * | 2021-12-01 | 2022-02-08 | 中国科学院深圳先进技术研究院 | Depression molding box and molding method |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201947761U (en) * | 2011-03-01 | 2011-08-31 | 成都华西海圻医药科技有限公司 | Separated rat breeding cage |
| US20140245966A1 (en) * | 2011-11-16 | 2014-09-04 | Eatron, Inc. | Cage for breeding small animals |
| CN204811424U (en) * | 2015-05-26 | 2015-12-02 | 唐佩福 | Experimental animals raises device |
| CN105110651A (en) * | 2015-08-14 | 2015-12-02 | 芜湖真空科技有限公司 | Glass fixing apparatus |
| CN204837438U (en) * | 2015-07-08 | 2015-12-09 | 浙江正特集团有限公司 | Modular pet cage |
| CN109156369A (en) * | 2018-09-30 | 2019-01-08 | 华中科技大学 | A kind of animal husbandry cage and the method for establishing depression mouse model using it |
| CN210746617U (en) * | 2019-09-09 | 2020-06-16 | 宁波大学 | Space constraint mouse cage |
-
2020
- 2020-06-19 CN CN202010564678.8A patent/CN111903541B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201947761U (en) * | 2011-03-01 | 2011-08-31 | 成都华西海圻医药科技有限公司 | Separated rat breeding cage |
| US20140245966A1 (en) * | 2011-11-16 | 2014-09-04 | Eatron, Inc. | Cage for breeding small animals |
| CN204811424U (en) * | 2015-05-26 | 2015-12-02 | 唐佩福 | Experimental animals raises device |
| CN204837438U (en) * | 2015-07-08 | 2015-12-09 | 浙江正特集团有限公司 | Modular pet cage |
| CN105110651A (en) * | 2015-08-14 | 2015-12-02 | 芜湖真空科技有限公司 | Glass fixing apparatus |
| CN109156369A (en) * | 2018-09-30 | 2019-01-08 | 华中科技大学 | A kind of animal husbandry cage and the method for establishing depression mouse model using it |
| CN210746617U (en) * | 2019-09-09 | 2020-06-16 | 宁波大学 | Space constraint mouse cage |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114009354A (en) * | 2021-12-01 | 2022-02-08 | 中国科学院深圳先进技术研究院 | Depression molding box and molding method |
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