CN111881132A

CN111881132A - Experimental animal management system and management method based on movable equipment

Info

Publication number: CN111881132A
Application number: CN202010654630.6A
Authority: CN
Inventors: 曹文妮; 袁凯; 刘志玮
Original assignee: Nanjing Best Information Technology Co ltd; Suzhou University
Current assignee: Nanjing Best Information Technology Co ltd; Suzhou University
Priority date: 2020-07-08
Filing date: 2020-07-08
Publication date: 2020-11-03

Abstract

The invention provides an experimental animal management system based on mobile equipment, which comprises a database system, a web front end and a mobile APP end, wherein the web front end is used for inputting data, the database system is used for storing the data and generating a cage card with a two-dimensional code label, and the mobile APP end is used for scanning the two-dimensional code label on the cage card to obtain animal information. The invention also provides an experimental animal management method based on the movable equipment. According to the cage card, the two-dimensional code is configured on the cage card, so that the information of the animal in the current cage position can be conveniently acquired at the mobile operation end through code scanning, errors in identification or writing can not occur, errors in subsequent operation can not be caused, and the reliability of data is greatly ensured.

Description

Experimental animal management system and management method based on movable equipment

Technical Field

The invention relates to the field of experimental animal record data tracing, in particular to an experimental animal management system and a management method based on movable equipment.

Background

The experimental animal is a very important resource in the field of life science research, and the management of the experimental animal is the most basic work in the process of carrying out animal experiments and is also very important. The completeness of animal information is extremely important for the tracing of experimental results, and informatization is always one appeal in experimental animal management.

Originally most experimental animal records are all based on the spreadsheet, write the cage card according to the information in the spreadsheet, show the animal information in the cage on the cage card. When obtaining animal information through a spreadsheet in conjunction with a cage card, several difficulties are encountered: 1. the complete display of animal information by using the electronic form is difficult to realize 2. the actual position of the animal is difficult to inquire and track 3. the animal cage card is limited in area, the displayed information is limited 4. the cage card writing brings about great possibility of identification error, and the readability is low.

Disclosure of Invention

In view of the above, the invention provides a laboratory animal management system and a laboratory animal management method based on mobile equipment, which solve the problems that the traditional electronic form is not comprehensive in animal information display and the identification of a handwriting cage card based on the electronic form is difficult.

Therefore, the invention provides a laboratory animal management system based on a movable device, which comprises:

the database system comprises a data storage module, an authority management module and a cage card generation module, wherein the data storage module stores animal data information; the authority management module opens a storage area in the corresponding data storage module according to the type of the user account to store the animal data information; the cage card generating module generates a unique ID (identity) associated with the input animal data information for each animal, and controls a printer to print the cage card with the two-dimensional code label, wherein the two-dimensional code label comprises ID information;

the web front end comprises a data entry module and a data acquisition module, the data entry module is used for entering animal data information, and the data acquisition module is used for acquiring the animal data information in the data storage module;

remove APP end, it includes identification module, identification module is used for discerning the two-dimensional code label on the cage card, acquires animal data information.

Furthermore, an information reminding module is further arranged in the database system, generates operation prompt information according to the input animal data information and sends the operation prompt information to the mobile APP terminal.

Further, the authority management module divides the user account into an administrator level, a subject group leader level and a common user level, wherein the administrator level allows the animal data information of all animals in the data storage module to be modified, the subject group leader level allows the animal data information of the animals of the subject group members in the data storage module to be modified, and the common user level allows the animal data information of the animals in the data storage module to be modified.

The invention also provides an experimental animal management method based on the movable equipment, which comprises the following steps:

1) logging in a web front end through a user account;

2) the data input module inputs animal data information to the data storage module;

3) the cage card generating module generates a cage card with a two-dimensional code label according to the input animal data information;

4) the information reminding module generates operation reminding information and sends the operation reminding information to the mobile APP terminal;

5) and scanning the two-dimensional code label on the cage card by the identification module of the mobile APP terminal to acquire animal data information, and finishing operation according to the operation prompt information.

Further, the animal data information includes strain, date of birth, genotype, label, generation number, hair color, description, source, parental information, current status, and storage cage position.

Further, in the step 2), when the animal data information is input by the data input module, the strain category preset in the data storage module is selected first, and then the animal data information can be filled in next step; the strain is not preset in the data storage module, and the strain name is added in the data storage module.

Further, in step 3), when the cage card is printed by the cage card generating module, the printing area further includes fields of strain abbreviation, contact person, location abbreviation, animal mark number, birth date and genotype.

Further, in the step 5), after the operation required by the operation prompt information is completed, the mobile APP terminal automatically deletes the operation prompt information.

According to the experimental animal management system and method based on the mobile equipment, the information of the animal in the current cage position can be conveniently acquired at the mobile operation end through code scanning in a mode of configuring the two-dimensional code on the cage card. In addition, the information of the animals is input through the Web front end, and important information such as the types, strain names, genotypes and the like of the animals is preset in a database system, so that an operator can be ensured not to have recognition errors in the using process. Cage card adopts the mode of printing to make, and the printing area includes two-dimensional code label and some animal basic information, avoids because writing the problem, causes the mistake in the follow-up operation, very big assurance data reliability.

Drawings

Various other advantages and benefits will become apparent to those of ordinary skill in the art upon reading the following detailed description of the preferred embodiments. The drawings are only for purposes of illustrating the preferred embodiments and are not to be construed as limiting the invention. Also, like reference numerals are used to refer to like parts throughout the drawings. In the drawings:

fig. 1 is a flow chart of a method for managing laboratory animals based on mobile equipment according to an embodiment of the present invention;

fig. 2 is a bottom structure and a relationship between data storage modules in the experimental animal management system based on the mobile device according to an embodiment of the present invention;

fig. 3 is a functional configuration of a web front end in an experimental animal management system based on a mobile device according to an embodiment of the present invention;

fig. 4 is a functional configuration of a mobile APP end in an experimental animal management system based on a mobile device according to an embodiment of the present invention;

fig. 5 is a data interaction mode of each part in the experimental animal management system based on the mobile device according to the embodiment of the invention.

Detailed Description

Exemplary embodiments of the present disclosure are described in detail below with reference to the accompanying drawings. While exemplary embodiments of the present disclosure are shown in the drawings, it should be understood that the present disclosure may be embodied in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art.

The first embodiment is as follows:

referring to fig. 1 to 5, a mobile device-based laboratory animal management system according to a first embodiment of the present invention is shown, including: the system comprises a database bottom layer, a web side management page and a mobile side APP. The WEB system is connected with the database through JDBC, the browser accesses the WEB system through HTTP protocol, and the flat panel APP accesses the API disclosed by the WEB system through RESTAPI mode.

The database contains the following modules:

1. user information management: and (4) registering a new user, and importing an account password for system login. The login mode can use an account password and additionally provides a two-dimensional code identity card for login. The users are divided into three levels, namely an administrator (feeding group leader), a topic group leader (PI) and ordinary users (including students, experimenters and breeders), the administrator can check all animal information, the topic group leader can check the animal information of all members of the topic group, and the ordinary users can only check the animal information of the ordinary users.

2. Facility, cage layout setting are raised: according to the actual feeding condition, the layout of the feeding facility, the number of feeding cages in the facility and the number of cages of each cage are set, and the fixed cage position (such as a sentinel cage) is set.

3. Animal type setting: the type of animal, such as mouse, rat, etc., is set.

4. Cage type setting: according to the use purpose, a plurality of different cage positions are designed, such as breeding cages, stock cages, sentinel cages, single-emasculation cages and the like, and each cage position has corresponding logic limitation and corresponding operation type.

5. Strain setting: the strain management information comprises information such as strain type, strain name, strain short, strain number, introduction date, introduction algebra, related genes, sources and the like, the living body quantity of each strain is displayed in near real time, and the strain is conveniently managed integrally.

6. Genotype setting: and setting a corresponding genotype marking type according to the line type, for example, setting the line type as 'knock out first tm1 a', setting the corresponding genotype to be related as 'tm 1a +/-, tm1a-/-, wt and fail', and standardizing the genotype marking mode.

7. Animal information management: each animal obtains a unique ID, and all relevant information of the animal is stored in an associated mode, including: strain full name, birth date, genotype, label, algebra, hair color, description (remark), source, parental information, current state, position of storage cage, etc.

8. And (3) label management: the two-dimension code label is divided into a user two-dimension code label and a cage two-dimension code label. The user two-dimensional code label is used for logging in an APP (animal steward) at a mobile terminal. The cage two-dimensional code label corresponds to each cage position actually used in the system and is used for the mobile terminal to scan the code to obtain the relevant information of the cage position.

9. Printer management: the background integrates the management function of the printer, a plurality of two-dimensional code printing devices can be added in a user-defined mode, each device is configured with a unique account number and a unique password, and the plurality of printing devices are allowed to exist simultaneously in one network segment. The printer program can add many printers simultaneously, can select the printer that needs to use at present on corresponding APP, receives the printer name according to the selection after the task at the printer program and sends the print job to corresponding equipment through the account number password that corresponds and accomplish the print job. Different printing templates are defined according to cage types, such as stock cages, breeding cages, sentinel cages and the like: besides the two-dimensional code is fixedly displayed in the printing area, fields such as strain abbreviation, contact person abbreviation, position abbreviation, animal mark number, birth date and genotype can be selected by user according to different cage box types and displayed in the printing area.

10. And (3) feeding report management: and storing abnormal data related to cage positions, such as abnormal reports generated when a breeder visits or changes cages, wherein the abnormal reports comprise literal descriptions and photo archives so as to facilitate the situation acquisition of a breeding group leader and experimenters.

11. Basic feeding operation: the basic operations are defined, and mainly comprise report birth, numbering, gene identification, cage separation, mating, thrombus detection labeling and the like. After the corresponding operation is executed, the related animal information is newly added, added and edited.

12. Basic experimental operation: basic experiment operations are defined, mainly comprising weight measurement, anal temperature measurement and the like, and data are added to information of corresponding animals after execution.

13. Work reminding management: the system automatically generates corresponding reminders according to the cage positions and the conditions of the animals in the cage positions, such as birth check, numbering, cage separation reminding and the like, and supports self-defined reminding addition. The reminding information can be directly synchronized to the personal account, is displayed in the APP and is convenient to directly jump to corresponding operation.

The Web end management page has the following functions:

1. setting strain types: most line types such as transgenes (transgenes), inbred lines (inbreds), closed groups (0 utbred), knock-outs (knock-outs) and the like are preset in the system, and a lower-level type such as cre (Tg) can be set under each type and is defined under the transgenes. The user can perform customized addition according to a multi-level structure as required.

2. Newly adding strains: the strain can be added at the webpage end, the strain addition needs to input necessary information such as strain name, strain abbreviation, strain number and the like, and needs to select from preset strain types, and the related genes and the strain types are related to obtain corresponding genotype options.

3. The newly added genotype: genotypes are added at the next level of the line type, no specific gene is involved, and the defined genotypes under the same line type are of a flat level and are used as options of the genotypes together to form a complete animal genotype together with related genes in the line setting.

4. Animal introduction: and selecting a corresponding feeding position or automatically allocating a position by a system for animal introduction, wherein the animal type and the corresponding strain name are required to be selected during introduction, and the number, sex, birth date, genotype, hair color, introduction algebra, description, state and the like of the animals to be introduced are recorded for introduction.

5. And (3) viewing animal information: animal information is provided in the animal management menu for viewing, the animal information is displayed by a cage box position basic unit, and various basic information of the animal can be viewed, wherein the basic information comprises strain names, labels, sexes, birth dates, genotypes, algebras, states, positions and the like. Meanwhile, a plurality of retrieval modes such as strain, sex, owner, age group and animal type are provided. Status, etc., for a particular animal. In addition, basic statistical information of the currently displayed cage position is integrally displayed, and the basic statistical information comprises the cage box number of stock cages, breeding cages, sentinel cages, single-mousing cages and the like, and information such as the number of mice in various types of cage positions, the number of over-aged mice, the number of mice in delayed cage division and the like, so that managers can visually know the overall situation of the cage position.

6. Gene identification: the entry of the animal genotype is carried out after the animal is introduced or tailed to generate the animal, and after the animal strain type, the related gene and the corresponding genotype are set, the entry of the genotype is simplified into a pull-down selection form, so that errors caused by input are avoided. In addition, animal batches can be selected for genotype entry by searching for a reduced range of animals displayed.

7. Basic feeding operation: basic feeding operations including mating, birth reporting, tail cutting, cage separation, death and the like can be completed at the Web end.

8. Feeding statistics: and counting the use condition of the whole feeding facility, and displaying the use condition of the cage position, the number of the strains of the fed animals and the number of the animals in near real time. The statistical time period can be customized, and the statistical range comprises the cost statistics according to facilities, topic groups and the like.

Web page setting and operating method

Logging in a breeding system by using the registered user name and password, and carrying out the following operations.

1. Strain import (administrator rights): before the animal is introduced, the related information of the animal strain needs to be introduced, so that the data tracing and association of the strain are convenient.

1) New strain type: the branch line types are newly established according to a plurality of preset types of lines (Transformer, Knockin, Knockout, Mutant, Conditional Knockout.) in the line type library.

2) New genotype: all the genotypes possibly involved in the line are created according to the line type, for example, the transgenes have Tg +, wt and fail

3) New strain: creating a new strain according to known information of new animals, filling out a full name of the strain (standard name), a short name of the strain, an introduction date, an introduction algebra, a source, selecting whether to be disclosed, filling out related genes and selecting the type of the strain corresponding to the genes. After the completion of the submission, the strain information is displayed on a strain management home page, can be edited and modified, and can also track the number of all living animals of the strain according to the animal condition at the later stage.

2. Animal introduction: firstly, the strain of the animal is ensured to be stored in a strain library (namely, the strain is imported), the basic information is filled in a standard and complete way, so that the subsequent cage position distribution and verification can be ensured, the animal information is filled in a standard and complete way, and the information association and tracking of the subsequent animals of the same strain can be ensured.

1) Basic information: introducing date, animal type, feeding order (selecting corresponding topic group number, facilitating later cage position distribution and checking), selecting import mode (manual import and Excel import), selecting import position (automatic acquisition and designation), selecting target room, and the like;

2) animal information: selecting strain full name (selected from strain library), birth date, genotype (optional filling), mark number, algebra, hair color, etc.;

3. animal management: animal information is checked, searching can be specified, and various operations can be carried out.

1) View animal information: the strain is short for, and the strain is marked with a mark, sex, birth date, genotype, hair color, algebra, state, position and the like, the number of stock cages and breeding cages and the number of animals of types such as stock, breeding, single placement, ligation and the like can also be checked, the reminding of overdue cages and untimely cages can also be carried out, and the time managers of the overdue cages and untimely cages can set the time.

2) Searching: there are retrieval modes such as line-by-line search, age-by-age search, description (remark) -by-description search, state-by-state search, and the like.

3) Operation: the handling of individual animals is sacrifice, editing, moving/caging, genetic identification, modifying status, breeding, etc.

a. And (3) killing: selecting animals needing to be killed, clicking a sacrifice button, selecting reasons for sacrifice (which can be set, such as death, unqualified, customer handing over, elimination, inspection, and the like), submitting and deleting.

b. Editing: the corresponding animal is selected, and the editing is clicked, so that the information such as line name, birth date, label number, algebra, fur color, description and the like can be modified, the gender cannot be modified, and the gender can be modified when the state of the newborn baby is in the breeding cage.

c. Moving/cage separation: selecting animals (including newborn cubs) needing to be moved/divided into cages, clicking to move the divided cages to change the positions, target rooms, the number and the states of the cages, dividing the cages into new positions after submitting the cages, and finally printing new two-dimensional codes again.

d. Gene identification: selecting corresponding animals, clicking gene identification, selecting genotype which is set according to the determined genotype when the strain is introduced, and directly selecting when filling.

e. And (3) modifying the state: selecting corresponding animal, modifying state, and setting state in advance, such as stock, reproduction, single placement, ligation, etc.

f. Preparing and breeding: selecting male mice and female mice needing mating, clicking for breeding, filling related information (offspring strain, mating date and the like), and finally submitting, wherein the numbers of the born mice and the tail cut can be checked and reported in a breeding cage menu at the later stage.

The operation of the whole cage is as follows: cleaning the cage, editing the cage, moving the cage, modifying the status, printing the cage, and changing the contact.

a. Cage cleaning: selecting a cage needing to be treated, clicking to clean, selecting a reason for sacrifice (setting, and performing sacrifice operation with a single animal), and submitting.

b. Moving a cage: the selection cage is designated to move to a new location.

c. And (3) modifying the state: similar to the single animal modified state, except that this operation was to modify the cage state, the single animal modified only the single animal state.

d. Printing a cage: the two-dimension code of the cage is printed, a newly generated cage is selected to be printed, or the two-dimension code with damage and unclear original two-dimension code is selected to be printed again, and the printing can be carried out for many times.

e. And changing the contact person: handing over within a facility requires changing contacts, and handing over within a subject group: and directly selecting a corresponding cage, clicking to change the contact person, and selecting the corresponding contact person, wherein if the contact person is handed over and changed among the subject groups, the administrator is required to have the authority to change order information, and the corresponding contact person is selected.

4. Raising the cage: and checking the cage position use condition of the rearing cage frame in the facility and the animal information of each cage position.

1) The total cage position number is set according to actual conditions, the use condition can be checked according to the leading-in and breeding conditions in the later stage, namely how many remaining cage positions are used by the cage.

2) And viewing the animals at the corresponding positions of the cage, wherein the cage can select a cage box display mode according to the requirements to view the specific requirements, for example, the strain name and the contact person at each position can be seen by selecting and displaying the strain name and the contact person for short. The operation method is consistent, corresponding strategies can be selected according to different requirements, and the operation method is flexible and diverse, and the operation method can be used flexibly.

5. Breeding cages: after the animal management page is bred, the corresponding breeding cage information is viewed on the breeding cage page and the litter and tailtrim numbers are reported. The breeding cages which need to be checked for birth, tail shearing and cage separation can be checked, the reminding for checking for birth, tail shearing and cage separation is mainly used, the breeding cages which need to be checked for birth, tail shearing and cage separation automatically disappear after tail shearing and cage separation and are not reminded, and the reminding for identification is needed (newly born cubs do not fill in genotypes).

1) Searching and checking breeding cage information including strain name, mating date, mark number, location and the like, wherein female mice in the breeding cages can fill in the bolting date, and animals in the breeding cages can be removed or newly added animals can be designated according to actual conditions.

2) Reporting the birth date of the newborn cubs, judging whether the newborn cubs need to be identified or not, and filling out the generation number of the newborn cubs.

3) And clipping tail numbers (generating animals), namely numbering newborn cubs, wherein the numbering rule is the automatic sequential numbering of animals of the same strain, namely clicking the checked breeding cage interface to generate the animals, filling in the number of males and females, updating to finish the sequential automatic numbering, and manually changing the numbering. Meanwhile, the information of the newly born cubs in the breeding cage can be checked.

4) Checking, birth checking, tail trimming, cage sorting and to-be-identified cub sorting, facilitating arrangement and planning of work, setting a reminding time by an administrator, automatically reminding when the date is reached, for example, a mouse is born about 21 days after reproduction, tail trimming is carried out 5-7 days after birth, and cages are sorted about 20 days after birth, wherein after corresponding time is set in an application setting mode, as long as a mating date and a birth date exist, the reminding of checking, birth building, committee sorting, cage sorting and identification can be reminded at specified time.

6. Feeding statistics: and counting the use condition of the whole feeding facility, and displaying the use condition of the cage position, the number of the strains of the fed animals and the number of the animals in near real time. The statistical time period can be customized, and the statistical range comprises the cost statistics according to facilities, topic groups and the like, so that the use condition of all cage positions in the facilities can be known.

7. Application settings (administrator rights): basic setting, animal type management, sacrifice reason management, animal hair color management, animal state management and cage display management.

1) The basic setting comprises the settings of birth checking, tail shearing reminding, cage separation reminding and aging exceeding time, as well as the setting of animal number rules and cage card (two-dimension code) storage days, wherein the storage days are the default failure time of the two-dimension code if the two-dimension code is not used for a long time, so that the cage which is not processed always occupies the cage position.

2) Animal type management: i.e. one option setting to select or change the animal type when importing and editing the animal, can be customized by the administrator according to the actual situation, e.g. mouse, rat, etc.

3) The management of the reason for sacrifice, that is, the setting of the reason for sacrifice selected at the time of sacrifice, may be changed or added as needed.

4) Animal hair color management: animal hair colors are set, and then selected in import or editing, and all possible hair colors are listed according to actual conditions.

5) Animal status management: multiple states may be set for later selection, such as inventory, reproduction, singles, and so on.

6) Cage display management: namely the above mentioned arrangement in the feeding cage, and the content options that need to be displayed by the feeding cage can be viewed and arranged at the side.

The setting of the Web end is comprehensive and standard, the normalization of various data imported or bred in the later period is guaranteed, the management and guidance of an administrator are facilitated, the association of the data can be guaranteed, and the statistics and the checking are facilitated.

The mobile terminal APP has the following functions:

1. work reminding: after the individual account is used for logging in the APP, the individual to-do matters can be directly seen, including birth check, tail cut and cage separation reminding which are automatically generated by the system and are about breeding cages, and self-defined work reminding. The reminding is not displayed after the related reminding content of the breeding cage to be handled is finished, and the reminding content can be manually finished and deleted after the user-defined work reminding is finished, so that repeated operation is avoided, and the accuracy of data information is ensured.

2. Selecting the printer currently in use: in any non-input box, the two-dimensional code of the printer to be used is directly scanned by the code scanning gun, so that the current printer can be directly switched to use, and the switching of working scenes is facilitated.

3. Scanning the code to check the animal information in the cage: animal information in the cage box is checked by scanning the two-dimensional code on the cage card. The stock cage information displays the mark number, the sex, the birth date, the strain abbreviation, the genotype, the hair color, the algebra, the state and the description of the animal, and displays the allowed operations of the stock cage, such as sacrifice, movement, breeding and the like; the breeding cage is additionally provided with a mating date and cub information display function and an operation of submitting a date to see the cottage date besides information and related operations displayed by the stock cage.

4. And (3) preparation and propagation operation: mating the animals at sexual maturity, firstly scanning a male stock cage, selecting male animals, clicking the female stock cage for breeding, then scanning the female stock cage for female, next selecting mating date and offspring strain name (facilitating the automatic generation of strain name and the filling of genotype of the subsequently generated newborn cub), submitting the two-dimensional code which can be printed to newly-built breeding cage, and pasting the two-dimensional code at a specified position.

5. Examination of birth: the system can automatically generate a reminder according to the mating date recorded when the breeding cage is created and the interval time for checking birth set by the system, and the reminder is displayed in the event to be handled. And (4) checking the newborn animals according to a prompt, if the breeding cage has the newborn, scanning codes to report the birth date on APP, and selecting the birth date, wherein if the animals related to gene identification can select 'no identification, all identification, only identification of male and only identification of female', and the sampling range is determined conveniently when the tail is cut. The post-litters breeding cage interface automatically updates a birth record.

6. Numbering: according to the birth record recorded by the system and the preset numbering time interval, the system can automatically generate the numbering task reminder to be displayed in the to-do matters. After finding the corresponding breeding cage and scanning the code, numbering can be performed in the generated birth record. The number of the male animals and the number of the female animals are recorded, the system automatically distributes numbers according to the rule from small to large according to the animal information of the current strain, and the information of the cubs can be generated in the system after the numbering is submitted.

7. Dividing a cage: the animals need to be separated from parents after weaning, so that enough growth space is provided for the animals. According to the birth record recorded by the system and the preset cage separation time interval, the system can automatically generate the cage separation task reminder to be displayed in the to-do matters. After finding the corresponding breeding cage and scanning the code, the corresponding cubs can be selected to be divided into cages, new stock cages are generated after the cages are divided, two-dimensional codes are generated, and the two-dimensional codes are pasted at the designated positions.

8. Moving: the system supports the movement of animals among cage positions, the animals needing to be moved are selected after the yard is scanned, and the moving operation can be completed by scanning the moved cage positions.

9. And (3) killing: the method comprises the steps of eliminating animals which do not meet the requirements, scanning a cage two-dimensional code, selecting animals to be sacrificed, carrying out sacrifice operation, and selecting the reason for sacrifice. The reason for the death can be set by self-definition according to actual requirements, and is added into the record of the animal, so that the death time and the reason can be conveniently checked in the later stage.

10. Measurement data: the system can support simple input of measurement data, and the type and data format of the record can be set in the background. And selecting a corresponding animal after the cage position of the animal needing to be measured is scanned, clicking the measurement data, filling corresponding data, submitting the data, storing the data into the information of the corresponding animal, and displaying or exporting the data at a webpage end.

11. Feeding report: the problem that the report was found is reminded, can submit the feeding report after the cage position scanning two-dimensional code to the problem that appears, and the report contains description and image, and the record corresponds corresponding cage position to cage position owner and administrator can in time know.

APP application method

Logging in by using an account and a password consistent with a breeding system (an administrator account, a breeding group leader account and a breeder account have different authorities)

1. Main menu: and displaying work reminding, namely displaying the reminding of checking birth, needing to cut tail and needing to divide the number of each item of cage, and manually editing the added work reminding by self.

2. Raising the cage: the cage position monitoring system is consistent with the functions of the feeding cages in the Web page of the feeding and breeding system, can check the cage position using condition of each cage position, can specifically check the animal information of a certain cage position, and can perform various operations (killing, moving/separating cages, editing, printing, changing contacts and the like).

3. Breeding cages: the breeding cage in the APP can not be searched, only the information display of the breeding cage which needs to check birth, cut tail and divide cage is reminded, the APP is used in the animal house to search the breeding cage, and the code is directly scanned to check. According to the information of the breeding cage, the breeding cage can be directly accessed into the breeding cage and relevant operations (tail cutting, cage separation, processing and the like) can be carried out.

4. Scanning codes and checking: the two-dimensional code is divided into two categories, namely a storage cage and a breeding cage, each cage position is provided with a corresponding two-dimensional code, and the codes are directly scanned to check animal information and perform various operations. Sweep a yard rifle and be connected with the mobile device bluetooth, directly can show on APP with sweeping yard rifle scanning cage two-dimensional code, also has on the APP simultaneously to sweep a sweep function, also can directly scan the two-dimensional code with the mobile device.

1) An inventory cage: the inventory cage information is displayed by scanning codes, the information including the position of the inventory cage, the sex, strain name, genotype, birth date, hair color, algebra and the like of the animals inside can be displayed in detail, and the checking is convenient. Besides displaying the information, the animal in the cage box can be subjected to related operation, namely the operation is consistent with that of an animal management page mentioned by a Web page, the APP terminal operates on the animal in a single cage of a single two-dimensional code, and the Web terminal operates on the whole. The APP terminal selects corresponding animals, and can perform operations such as sacrifice, cage moving/dividing, gene identification, state modification, matching and reproduction, and the like, and the operations are different except the cage moving/dividing, the reproduction and the Web page operation, and the others are kept consistent. The specific method for moving/cage-dividing and breeding the APP end is as follows:

a. moving/cage separation: aiming at the movement of animals in the stock cage, the animals are selected firstly, the movement/division cage is clicked, if the animals are divided into new cage positions, the position is defaulted, if the animals are divided into the existing stock cages, the position is selected to be a designated position, the two-dimensional code of the designated position is scanned, meanwhile, the number of each cage and the state after the movement can be modified, and finally the animals are submitted. And if the cage is a new cage, the two-dimensional code of the cage needs to be printed, and if the cage is an existing stock cage, the two-dimensional code of the cage does not need to be printed.

b. Preparing and breeding: stock cage males and stock cage females mate to create new breeding cages. Scanning the two-dimensional code of the male rat cage, selecting the male rat to click for breeding, jumping out of a breeding dialogue box, scanning the two-dimensional code of the female rat cage, selecting the female rat, finally filling in the mating date, the name of the offspring strain (selecting the existing strain in the strain library, and leading the strain if the offspring strain does not exist) and other related information, submitting, and generating a new breeding cage and printing.

2) A propagation cage: the operation of breeding cages is carried out according to the reminding, the breeding cages which are born, tailed and divided are reminded to be checked, the corresponding cages are found in the animal rooms, and the checking and the operation can be carried out by scanning the code. Animal information and various operations displayed after code scanning are consistent with those of the stock cage, the difference is that the breeding cage is divided into parents and newborn cubs, information such as mating dates and offspring strain names can be checked and modified, and the operations of reporting the fares and cutting tails can be performed.

a. Reporting the cubs: if the breeding cage is born, the breeding cage reports the birth of the baby, fills in the birth date and the generation number, selects whether to identify or not, and adds other remarks.

b. Tail shearing: each birth record is followed by a tail clipping operation and a deleting operation, and if the birth information is reported to be wrong, the birth record can be deleted and refilled. The tail shearing operation is to number the newborn cubs, fill in the number of males and females, and update the number to be sequentially and automatically numbered (the same line is sequentially numbered); the numbering can be manually cleared or renumbered according to the requirement of the user, the numbering can be cleared if the numbering is not required, the numbering can be clicked to renumber after the first numbering is filled in if the numbering is required, the numbering is automatically and sequentially increased in the following process, and one filling is not required.

Attention points to the operation

After the tail shearing number is finished, the breeding cage can automatically generate new cubs, all information of the new cubs are from a series of previous operations, the line name is from the name of offspring lines in a line library selected by parents during breeding, the birth date and the generation number are from information filled when the cubs are reported, and the quantity, the gender and the number are generated by the tail shearing number. And every birth record of this breed cage all remains, can show the cub quantity after cutting the tail number, the later stage of being convenient for is to the view and the analysis of this cub condition of breeding the cage. A series of information in the breeding process is completely and accurately filled, the accuracy of the finally generated data is guaranteed, and later-stage data sorting and statistical analysis are facilitated.

Importing animals into a Web page, wherein the step of newly building and filling basic information comprises the following steps: basic information such as date, animal type, animal name, quantity of each sex of the animal, number of animals, feeding order, target room and the like is introduced, most importantly, the selection of the feeding order and the selection of the target room are selected, the feeding order mainly comprises the customer order number of the subject group, the source of each subject group of the animals and the use condition of the cage position are convenient to count at the later stage, and the target room is the facility to which the animals need to enter so as to distribute the cage position. The next step of filling out animal information comprises: the lines are named completely (selected from the existing lines in the system, if not introduced into the line), birth date, genotype (selected from the existing lines, if not introduced first), mark number, algebra, hair color, description (i.e. remarks). And the information can be completely filled and then the next step of importing can be carried out.

The completeness of the imported animal information ensures the information tracing in the future, the strain name during import needs to be selected from the names which are available in the system and invalid in filling, the system cannot identify, and strains which are not available in the system need to be imported in advance. The selection of the feeding order and the target room facilitates future data statistics and cage allocation.

The operation of cutting the tail number is carried out to corresponding breed cage, fills in male and female quantity, and automatic numbering generates the new-born cub to the new-born cub of same strain can be automatic numbering in order, forgets from where to begin the numbering when avoiding follow-up cutting the tail, and can set up and cut tail warning time, cuts the tail to the mouse that reports the cub and reminds at the head page, so that in time cut the tail.

Divide the cage operation to set up and remind the time, remind branch cage after waiting for the animal to grow up to in time divide the cage, divide the cage to arrive corresponding reproduction cage promptly, will grow up newborn cub select move/divide the cage can, the animal that divides the cage newly can divide automatically into new empty cage position, generate new label, divide the back direct print label well, paste correspond cage box on can, the animal that divides away can trace back its source parents in the system equally.

The moving operation is similar to the cage separating operation, the moving operation is separated into the existing cage boxes, and the cage separating operation is separated into the new cage boxes. When the mobile operation is carried out, the specified position is selected, and the specific position selection is found.

And (4) performing a sacrifice operation, namely selecting the animals which are appointed to be sacrificed, and performing the sacrifice operation. The reason for the sacrifice, such as natural death, removal from the facility, identification of unsatisfactory causes, etc., is selected for the sacrifice operation, so that the time of death, the cause of death, etc., can be queried later.

It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.

Claims

1. An experimental animal management system based on movable equipment is characterized by comprising:

the system comprises a database system, a data storage module, a permission management module and a cage card generation module, wherein the data storage module stores animal data information; the authority management module opens a corresponding storage area in the data storage module according to the type of the user account to store animal data information; the cage card generating module generates a unique ID (identity) associated with the input animal data information for each animal, and controls a printer to print the cage card with the two-dimensional code label, wherein the two-dimensional code label comprises ID information;

2. The experimental animal management system based on the movable equipment as claimed in claim 1, wherein an information reminding module is further arranged in the database system, and the information reminding module generates operation prompt information according to the entered animal data information and sends the operation prompt information to the mobile APP terminal.

3. The experimental animal management system based on the mobile device as claimed in claim 1, wherein the authority management module divides the user account into an administrator level, a subject group leader level and a general user level, the administrator level allows modification of animal data information of all animals in the data storage module, the subject group leader level allows modification of animal data information of animals in a subject group member in the data storage module, and the general user level allows modification of animal data information of own animals in the data storage module.

4. A laboratory animal management method based on movable equipment is characterized by comprising the following steps:

1) logging in a web front end through a user account;

5. The experimental animal management method based on mobile equipment as claimed in claim 4, wherein the animal data information comprises strain, birth date, genotype, mark number, algebra, fur color, description, source, parental information, current status, and storage cage position.

6. The experimental animal management method based on the movable equipment as claimed in claim 5, wherein in the step 2), when the animal data information is entered by the data entry module, the strain category preset in the data storage module is selected first, and then the animal data information can be filled in the next step; the strain is not preset in the data storage module, and the strain name is added in the data storage module.

7. The experimental animal management method based on the mobile device as claimed in claim 4, wherein in the step 3), when the cage card is printed by the cage card generation module, the printing area further includes fields of strain abbreviation, contact person, location abbreviation, animal identification number, birth date and genotype.

8. The experimental animal management method based on the mobile device as claimed in claim 4, wherein in the step 5), after the operation required by the operation prompt message is completed, the mobile APP terminal automatically deletes the operation prompt message.