CN111840580A - Special angiographic agent for corpses and preparation method thereof - Google Patents
Special angiographic agent for corpses and preparation method thereof Download PDFInfo
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- CN111840580A CN111840580A CN202010725294.XA CN202010725294A CN111840580A CN 111840580 A CN111840580 A CN 111840580A CN 202010725294 A CN202010725294 A CN 202010725294A CN 111840580 A CN111840580 A CN 111840580A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0452—Solutions, e.g. for injection
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Abstract
The invention provides a special corpse angiography agent, which is prepared by mixing an iodo-benzene ring compound and a fat-soluble solvent with specific viscosity. The special corpse angiography agent prepared by the iodo-benzene ring compound and the fat-soluble solvent with specific viscosity not only solves the technical problem that clinical water-soluble iodine angiography agents are easy to permeate outwards through the wall of a corpse blood vessel or leak outwards along the tail end of the blood vessel to cause edema of tissues around the corpse blood vessel or abnormal increase of image density, but also improves the current situation that the clinical fat-soluble iodine angiography agents cannot be used for corpse angiography in large quantity due to high price.
Description
Technical Field
The invention relates to the field of corpse angiography agents, in particular to a corpse special angiography agent and a preparation method thereof.
Background
The use of tomosynthesis for non-invasive, minimally invasive or scalpel-free autopsy is a general trend in the development of forensics in the world. The corpse angiography can improve the capability of detecting injury and diseases of the corpse vascular system and is helpful for diagnosing the death cause.
After a human body dies, the permeability of the vascular wall is gradually increased, and the vascular tail end is autolyzed and even decayed, so that when a clinical water-soluble iodine contrast agent is used for corpse angiography, the contrast agent can quickly permeate outwards from the vascular wall or leak outwards along the vascular tail end to cause edema of tissues around the blood vessel or abnormal increase of image density, thereby affecting the effect of corpse angiography. The use of fat-soluble iodine contrast agents is a trend in cadaver angiography.
In the process of corpse angiography, the dosage of the contrast agent is large, hundreds of milliliters of corpse target organ angiography is needed, and a plurality of liters of corpse whole body angiography is needed. Although clinical fat-soluble iodine contrast agents, such as iodized oil, can meet the requirements of corpse angiography, the clinical fat-soluble iodine contrast agents are expensive, and the application of the clinical fat-soluble iodine contrast agents in corpse angiography is limited. The search for a low-price fat-soluble iodine contrast agent is a practical requirement of corpse angiography.
Cadaver angiography requires the use of a lipid soluble contrast agent of suitable viscosity. If the viscosity of the fat-soluble contrast agent is too high, the contrast agent is difficult to enter small vessels of corpses, so that the angiography is incomplete; if the viscosity of the fat-soluble contrast agent is too low, the contrast agent can enter the corpse microcirculation, so that the overall contrast quality of corpse angiography is influenced. The invention discloses a special fat-soluble iodine contrast agent for corpses, which is low in price and has specific viscosity, and is an urgent need at present.
Disclosure of Invention
The invention overcomes the defects in the prior art, provides a special corpse angiography agent and a preparation method thereof, and aims to provide a special corpse liposoluble iodine angiography agent which has low price, simple preparation process and easy industrial mass production and meets the requirement of corpse blood vessel viscosity.
The purpose of the invention is realized by the following technical scheme.
The special corpse angiography agent comprises an iodo-benzene ring compound and a specific viscosity fat-soluble solvent, wherein the iodo-benzene ring compound and the specific viscosity fat-soluble solvent are mixed to obtain a fat-soluble iodine solution.
In the above scheme, preferably, the mass of iodine in the iodo-benzene ring compound accounts for 1% -8% of the mass of the fat-soluble iodine solution.
In any of the above schemes, preferably, the mass of iodine in the iodo-benzene ring compound accounts for 2% -6% of the fat-soluble iodine solution.
In any of the above schemes, preferably, the mass of iodine in the iodo-benzene ring compound accounts for 3% -4% of the fat-soluble iodine solution.
In any scheme, the iodo-benzene ring compound is one or more selected from a mono-iodo-benzene ring compound, a di-iodo-benzene ring compound, a tri-iodo-benzene ring compound, a tetra-iodo-benzene ring compound, a pentaiodo-benzene ring compound and a hexaiodo-benzene ring compound.
In any of the above schemes, preferably, the mono-iodo benzene ring compound is selected from iodinated benzene.
In any of the above schemes, preferably, the di-iodo benzene ring compound is selected from one or more of 1, 2-diiodobenzene, 1, 3-diiodobenzene and 1, 4-diiodobenzene.
In any of the above schemes, preferably, the triiodobenzene ring compound is selected from one or two of 1,3, 5-triiodobenzene and 1,2, 4-triiodobenzene.
In any of the above schemes, preferably, the tetraiodobenzene ring compound is selected from 1,2,4, 5-tetraiodobenzene.
In any of the above schemes, preferably, the pentaiodobenzene ring compound is selected from 1,2,3,4, 5-pentaiodobenzene.
In any of the above schemes, preferably, the hexaiodo-benzene ring compound is 1,2,3,4,5, 6-hexaiodo-benzene.
In any of the above schemes, preferably, the iodo-benzene ring compound is selected from bis-iodo compounds.
In any of the above schemes, preferably, the iodobenzene ring compound is selected from one of 1, 3-diiodobenzene and 1, 4-diiodobenzene.
In any of the above schemes, preferably, the iodo-benzene ring compound is selected from 1, 4-diiodobenzene.
In any of the above embodiments, the viscosity of the specific-viscosity fat-soluble solvent is preferably 20mPa · s to 100mPa · s at 20 ℃.
In any of the above embodiments, preferably, the liposoluble solvent with specific viscosity is liquid paraffin oil or oleic acid.
In any of the above embodiments, the liquid paraffin oil preferably has a viscosity of 20mPa · s to 70mPa · s at 20 ℃.
In any of the above embodiments, the liquid paraffin oil preferably has a viscosity of 30mPa · s to 35mPa · s at 20 ℃.
A preparation method of a special corpse angiography agent comprises the following steps,
weighing an iodo-benzene ring compound and a specific viscosity fat-soluble solvent according to the formula amount;
mixing the iodo-benzene ring compound weighed in the step one with a fat-soluble solvent with a specific viscosity, and continuously and rapidly stirring or shaking for 1-2 hours;
step three, transferring the mixed liquid obtained in the step two to a container for sealing, and storing for 12-24 hours at 20-25 ℃ in a dark place;
and step four, transferring the mixed liquid obtained in the step three to a CT (computed tomography) for scanning, and obtaining the special corpse angiography agent when an image with uniform density is observed.
The invention has the beneficial effects that:
compared with the clinical commonly used contrast agents of iohexol and iodized oil, the iodo-benzene ring compound has high iodine content, low price, easy industrial batch production and good compatibility with corpse blood vessels and tissues.
The fat-soluble solvent with specific viscosity can stay in the cadaver blood vessel for a long time, forms a micro fat plug at the cadaver blood vessel with the ideal diameter, and can prevent the contrast agent from permeating or leaking outside the cadaver blood vessel system.
The special corpse angiography agent prepared by the iodo-benzene ring compound and the fat-soluble solvent with specific viscosity not only solves the technical problem that clinical water-soluble iodine angiography agents easily permeate outwards through the wall of a corpse blood vessel or leak outwards along the tail end of the blood vessel to cause edema of tissues around the corpse blood vessel or abnormal increase of image density, but also improves the current situation that the clinical fat-soluble iodine angiography agents cannot be used for corpse angiography in large quantity due to high price.
The iodo-benzene ring compound and the specific viscosity fat-soluble solvent used by the invention have the advantages of low price and easy industrial mass production.
The invention relates to a fat-soluble iodine contrast agent, which can avoid the edema of tissues around corpse blood vessels or abnormal increase of image density caused by a clinical water-soluble iodine contrast agent on one hand, and also can improve the current situation that the clinical fat-soluble iodine contrast agent cannot be used for corpse blood vessel contrast in large quantity due to high price.
The invention can meet the requirement of corpse angiography on the specific viscosity of the contrast medium, on one hand, the incomplete corpse small angiography caused by the fact that the contrast medium cannot enter small blood vessels due to overlarge viscosity of the contrast medium can be avoided, and on the other hand, the situation that the integral contrast quality of the corpse angiography is influenced by the fact that the contrast medium enters corpse microcirculation due to the overlong viscosity of the contrast medium can be avoided.
Detailed Description
The technical solution of the present invention is further illustrated by the following specific examples.
The present invention is described in detail below to facilitate an understanding of the present invention.
Components of special angiographic agent for corpses
The special corpse angiography agent comprises an iodo-benzene ring compound and a specific viscosity fat-soluble solvent, wherein the iodo-benzene ring compound and the specific viscosity fat-soluble solvent are mixed to obtain a fat-soluble iodine solution.
The mass of iodine of the iodo-benzene ring compound accounts for 1-8% of the mass of the fat-soluble iodine solution; more preferably, the iodine mass of the iodo-benzene ring compound accounts for 2% -6% of the fat-soluble iodine solution; most preferably, the mass of iodine of the iodo-benzene ring compound accounts for 3% -4% of the fat-soluble iodine solution.
The iodo-benzene ring compound is one or more of a mono-iodo-benzene ring compound, a di-iodo-benzene ring compound, a tri-iodo-benzene ring compound, a tetra-iodo-benzene ring compound, a pentaiodo-benzene ring compound and a hexaiodo-benzene ring compound.
The mono-iodo benzene ring compound is iodinated benzene;
the double-iodo benzene ring compound is one or more of 1, 2-diiodobenzene, 1, 3-diiodobenzene and 1, 4-diiodobenzene.
The triiodobenzene ring compound is any one or two of 1,3, 5-triiodobenzene and 1,2, 4-triiodobenzene.
The tetraiodobenzene ring compound is 1,2,4, 5-tetraiodobenzene.
The pentaiodobenzene ring compound is 1,2,3,4, 5-pentaiodobenzene.
The hexaiodo-benzene ring compound is 1,2,3,4,5, 6-hexaiodo-benzene.
More preferably, the iodobenzene ring compound is diiodobenzene.
Most preferably, the iodobenzene ring compound is 1, 4-diiodobenzene.
The fat-soluble solvent with the specific viscosity is liquid paraffin oil or oleic acid.
Preferably, the liposoluble solvent with the specific viscosity is liquid paraffin oil, and the viscosity of the liquid paraffin oil at 20 ℃ is 20-70 mPa & s; preferably, the liquid paraffin oil has a viscosity of 20mPa & s-40mPa & s at 20 ℃; most preferably, the liquid paraffin oil has a viscosity of from 30 mPa.s to 35 mPa.s at 20 ℃.
Second, method for preparing special-purpose angiographic agent for corpse
A preparation method of a special corpse angiography agent comprises the following steps,
weighing an iodo-benzene ring compound and a specific viscosity fat-soluble solvent according to the formula amount;
mixing the iodo-benzene ring compound weighed in the step one with a fat-soluble solvent with a specific viscosity, and continuously and rapidly stirring or shaking for 1-2 hours;
step three, transferring the mixed liquid obtained in the step two to a container for sealing, and storing for 12-24 hours at 20-25 ℃ in a dark place;
and step four, transferring the mixed liquid obtained in the step three to a CT (computed tomography) for scanning, and obtaining the special corpse angiography agent when an image with uniform density is observed.
Example 1
The special corpse angiography agent comprises 200g of 1, 4-diiodobenzene and 5L of liquid paraffin oil with the viscosity of 30-35 mPa & s at 20 ℃, and is prepared according to the following steps:
weighing 1, 4-diiodobenzene and liquid paraffin oil according to the formula ratio under the ventilation environment of 20-25 ℃;
mixing 1, 4-diiodobenzene and liquid paraffin oil into a container, and continuously and rapidly stirring or shaking for 1-2 hours;
step three, transferring the liquid into a container, sealing, and storing for 12-24 hours at 20-25 ℃ in a dark environment;
and step four, transferring the liquid to a CT (computed tomography) for scanning, and obtaining the special corpse angiography agent when an image with uniform density is observed.
Example 2
The special corpse angiography agent comprises 200g of 1, 4-diiodobenzene and 5L of oleic acid and is prepared according to the following steps:
step one, weighing 1, 4-diiodobenzene and oleic acid in formula amount under the ventilation environment of 20-25 ℃;
step two, mixing the 1, 4-diiodobenzene and the oleic acid into a container, and continuously and rapidly stirring or shaking for 1-2 hours;
step three, transferring the liquid into a container, sealing, and storing for 12-24 hours at 20-25 ℃ in a dark environment;
and step four, transferring the liquid to a CT (computed tomography) for scanning, and obtaining the special corpse angiography agent when an image with uniform density is observed.
Example 3
The special corpse angiography agent comprises 200g of 1, 3-diiodobenzene and 5L of liquid paraffin oil with the viscosity of 30-35 mPa & s at 20 ℃, and is prepared according to the following steps:
weighing 1, 3-diiodobenzene and liquid paraffin oil according to the formula ratio under the ventilation environment of 20-25 ℃;
step two, mixing the 1, 3-diiodobenzene and the liquid paraffin oil into a container, and continuously and rapidly stirring or shaking for 1-2 hours;
step three, transferring the liquid into a container, sealing, and storing for 12-24 hours at 20-25 ℃ in a dark environment;
and step four, transferring the liquid to a CT (computed tomography) for scanning, and obtaining the special corpse angiography agent when an image with uniform density is observed.
Example 4
The special corpse angiography agent comprises 200g of 1, 2-diiodobenzene and 5L of liquid paraffin oil with the viscosity of 30-35 mPa & s at 20 ℃, and is prepared according to the following steps:
weighing 1, 2-diiodobenzene and liquid paraffin oil according to the formula ratio under the ventilation environment of 20-25 ℃;
mixing 1, 2-diiodobenzene and liquid paraffin oil into a container, and continuously and rapidly stirring or shaking for 1-2 hours;
step three, transferring the liquid into a container, sealing, and storing for 12-24 hours at 20-25 ℃ in a dark environment;
and step four, transferring the liquid to a CT (computed tomography) for scanning, and obtaining the special corpse angiography agent when an image with uniform density is observed.
Example 5
The special corpse angiography agent comprises 200g of 1,2, 4-triiodobenzene and 5L of liquid paraffin oil with the viscosity of 30mPa & s-35mPa & s at 20 ℃, and is prepared according to the following steps:
weighing 1,2, 4-triiodobenzene and liquid paraffin oil according to the formula ratio under the ventilation environment of 20-25 ℃;
step two, mixing the 1,2, 4-triiodobenzene and the liquid paraffin oil into a container, and continuously and rapidly stirring or shaking for 1-2 hours;
step three, transferring the liquid into a container, sealing, and storing for 12-24 hours at 20-25 ℃ in a dark environment;
and step four, transferring the liquid to a CT (computed tomography) for scanning, and obtaining the special corpse angiography agent when an image with uniform density is observed.
Example 6
The special corpse angiography agent comprises 200g of 1,3, 5-triiodobenzene and 5L of liquid paraffin oil with the viscosity of 30mPa & s-35mPa & s at 20 ℃, and is prepared according to the following steps:
weighing 1,3, 5-triiodobenzene and liquid paraffin oil according to the formula ratio under the ventilation environment of 20-25 ℃;
step two, mixing 1,3, 5-triiodobenzene and liquid paraffin oil into a container, and continuously and rapidly stirring or shaking for 1-2 hours;
step three, transferring the liquid into a container, sealing, and storing for 12-24 hours at 20-25 ℃ in a dark environment;
and step four, transferring the liquid to a CT (computed tomography) for scanning, and obtaining the special corpse angiography agent when an image with uniform density is observed.
Example 7
The special corpse angiography agent comprises 200g of 1,2,4, 5-tetraiodobenzene and 5L of liquid paraffin oil with the viscosity of 30mPa & s-35mPa & s at 20 ℃, and is prepared according to the following steps:
weighing 1,2,4, 5-tetraiodobenzene and liquid paraffin oil according to the formula ratio under the ventilation environment of 20-25 ℃;
step two, mixing 1,2,4, 5-tetraiodobenzene and liquid paraffin oil into a container, and continuously and rapidly stirring or shaking for 1-2 hours;
step three, transferring the liquid into a container, sealing, and storing for 12-24 hours at 20-25 ℃ in a dark environment;
and step four, transferring the liquid to a CT (computed tomography) for scanning, and obtaining the special corpse angiography agent when an image with uniform density is observed.
Example 8
The special corpse angiography agent comprises 200g of 1,2,3,4, 5-pentaiodobenzene and 5L of liquid paraffin oil with the viscosity of 30mPa & s-35mPa & s at 20 ℃, and is prepared according to the following steps:
weighing 1,2,3,4, 5-pentaiodobenzene and liquid paraffin oil according to the formula ratio under the ventilation environment of 20-25 ℃;
mixing 1,2,3,4, 5-pentaiodobenzene and liquid paraffin oil into a container, and continuously and rapidly stirring or shaking for 1-2 hours;
step three, transferring the liquid into a container, sealing, and storing for 12-24 hours at 20-25 ℃ in a dark environment;
and step four, transferring the liquid to a CT (computed tomography) for scanning, and obtaining the special corpse angiography agent when an image with uniform density is observed.
Example 9
The special corpse angiography agent comprises 200g of 1,2,3,4,5, 6-hexaiodobenzene and 5L of liquid paraffin oil with the viscosity of 30-35 mPa & s at 20 ℃, and is prepared according to the following steps:
weighing 1,2,3,4,5, 6-hexaiodobenzene and liquid paraffin oil according to the formula ratio under the ventilation environment of 20-25 ℃;
mixing 1,2,3,4,5, 6-hexaiodobenzene and liquid paraffin oil into a container, and continuously and rapidly stirring or shaking for 1-2 hours;
step three, transferring the liquid into a container, sealing, and storing for 12-24 hours at 20-25 ℃ in a dark environment;
and step four, transferring the liquid to a CT (computed tomography) for scanning, and obtaining the special corpse angiography agent when an image with uniform density is observed.
The nine embodiments of the present invention have been described in detail, but the description is only for the preferred embodiments of the present invention and should not be construed as limiting the scope of the present invention. All equivalent changes and modifications made within the scope of the present invention shall fall within the scope of the present invention.
Claims (13)
1. A special corpse angiography agent is characterized in that: the iodine-containing preparation method comprises an iodine benzene ring compound and a specific viscosity fat-soluble solvent, wherein the iodine benzene ring compound and the specific viscosity fat-soluble solvent are mixed to obtain a fat-soluble iodine solution.
2. The special cadaver angiographic contrast agent according to claim 1, wherein: the mass of iodine of the iodo-benzene ring compound accounts for 1% -8% of the mass of the fat-soluble iodine solution.
3. The special cadaver angiographic contrast agent according to any one of claims 1-2, wherein: the iodo-benzene ring compound is one or more of a mono-iodo-benzene ring compound, a di-iodo-benzene ring compound, a tri-iodo-benzene ring compound, a tetra-iodo-benzene ring compound, a pentaiodo-benzene ring compound and a hexaiodo-benzene ring compound.
4. The special cadaver angiographic contrast agent according to claim 3, wherein: the mono-iodo benzene ring compound is iodinated benzene.
5. The special cadaver angiographic contrast agent according to claim 3, wherein: the double-iodo benzene ring compound is one or more of 1, 2-diiodobenzene, 1, 3-diiodobenzene and 1, 4-diiodobenzene.
6. The special cadaver angiographic contrast agent according to claim 3, wherein: the triiodobenzene ring compound is any one or two of 1,3, 5-triiodobenzene and 1,2, 4-triiodobenzene.
7. The special cadaver angiographic contrast agent according to claim 3, wherein: the tetraiodobenzene ring compound is 1,2,4, 5-tetraiodobenzene.
8. The special cadaver angiographic contrast agent according to claim 3, wherein: the pentaiodobenzene ring compound is 1,2,3,4, 5-pentaiodobenzene.
9. The special cadaver angiographic contrast agent according to claim 3, wherein: the hexaiodo-benzene ring compound is 1,2,3,4,5, 6-hexaiodo-benzene.
10. The special cadaver angiographic contrast agent according to claim 3, wherein: the viscosity of the fat-soluble solvent with the specific viscosity at 20 ℃ is 20mPa & s-100mPa & s.
11. The special cadaver angiographic contrast agent according to claim 10, wherein: the fat-soluble solvent with the specific viscosity is liquid paraffin oil or oleic acid.
12. The special cadaver angiographic contrast agent according to claim 11, wherein: the viscosity of the liquid paraffin oil at 20 ℃ is 20mPa & s-70mPa & s.
13. A preparation method of a special corpse angiography agent is characterized by comprising the following steps: comprises the following steps of (a) carrying out,
weighing an iodo-benzene ring compound and a specific viscosity fat-soluble solvent according to the formula amount;
mixing the iodo-benzene ring compound weighed in the step one with a fat-soluble solvent with a specific viscosity, and continuously and rapidly stirring or shaking for 1-2 hours;
step three, transferring the mixed liquid obtained in the step two to a container for sealing, and storing for 12-24 hours at 20-25 ℃ in a dark place;
and step four, transferring the mixed liquid obtained in the step three to a CT (computed tomography) for scanning, and obtaining the special corpse angiography agent when an image with uniform density is observed.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114010804A (en) * | 2021-11-15 | 2022-02-08 | 吉林大学 | Angiography agent for corpses and preparation method thereof |
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|---|---|---|---|---|
| US20130045168A1 (en) * | 2006-09-18 | 2013-02-21 | Forim-X Ag | Radiographic contrast agent for postmortem, experimental and diagnostic angiography |
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- 2020-07-24 CN CN202010725294.XA patent/CN111840580A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130045168A1 (en) * | 2006-09-18 | 2013-02-21 | Forim-X Ag | Radiographic contrast agent for postmortem, experimental and diagnostic angiography |
Non-Patent Citations (1)
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| SILKE GRABHERR ET AL.: ""Two-Step Postmortem Angiography with a Modified Heart–Lung Machine: Preliminary Results"", 《AJR》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114010804A (en) * | 2021-11-15 | 2022-02-08 | 吉林大学 | Angiography agent for corpses and preparation method thereof |
| CN114010804B (en) * | 2021-11-15 | 2023-02-28 | 吉林大学 | Angiography agent for corpses and preparation method thereof |
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