CN111840510A - Application of food-borne polypeptides - Google Patents

Application of food-borne polypeptides Download PDF

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Publication number
CN111840510A
CN111840510A CN202010601569.9A CN202010601569A CN111840510A CN 111840510 A CN111840510 A CN 111840510A CN 202010601569 A CN202010601569 A CN 202010601569A CN 111840510 A CN111840510 A CN 111840510A
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polypeptides
virus
seq
food
infectious diseases
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陈正望
雷燕
尧晨光
陈琼荣
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Huazhong University of Science and Technology
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Huazhong University of Science and Technology
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

The invention belongs to the field of biological medicine, and discloses application of a group of food-borne polypeptides, wherein the amino acid sequences of the group of polypeptides are shown as SEQ ID: 1-SEQ ID:23, and the polypeptides are used for preparing medicines for preventing and treating virus or bacterial infectious diseases and special medical food or health-care products for preventing the virus or bacterial infectious diseases. Moreover, the polypeptides are particularly food-borne polypeptides, and the sources of the polypeptides can be food which is selected and formed by human for meeting the requirements of living and breeding offspring for a long time, and the polypeptides do not cause toxic and side effects of human bodies, drug resistance and other negative effects when being used for preparing medicaments for preventing and treating virus or bacterial infectious diseases and special medical foods or health-care products for preventing the virus or bacterial infectious diseases.

Description

Application of food-borne polypeptides
Technical Field
The invention belongs to the field of biological medicine, and more particularly relates to application of a group of food-borne polypeptides, including application of the group of food-borne polypeptides in preparation of medicines for preventing and treating virus/bacterial infectious diseases, and the like, wherein the amino acid sequences of the group of food-borne polypeptides are respectively shown as sequences SEQ ID: 1-SEQ ID: 23.
Background
Viruses and bacteria are important pathogens present in human survival and development. To prevent the infection of the human cells by viruses and bacteria and to prevent the invasion of the human cells, effective measures are taken to intervene according to the propagation mode and pathogenic mechanism of the viruses and bacteria. The main effective ways are: 1. depending on the morphological structure of the virus and bacteria and the chemical composition of the outer shell, effective measures are taken to block the adhesion, invasion and release of the virus and bacteria to the host cell. 2. The genome structure, the expression process and the regulation mechanism of the genetic materials of the viruses and the bacteria are determined, the replication expression of the genetic materials of the viruses and the bacteria in host cells is inhibited, and a new generation of the viruses or the bacteria is generated.
In the above point 1, the method currently used is to inoculate a non-toxic vaccine to make the human body produce antibodies against the virus, and then to use chemical drugs to destroy the binding and invasion of the virus to the host cell. The vaccination generates antibody in human body, which is only effective against known virus/bacteria, and has no immune effect against new variant virus/bacteria. For the above point 2, chemical drugs are also currently used, which interfere with the synthesis and replication of viral and bacterial genetic materials in host cells, thereby blocking the regeneration of viral particles and the propagation of bacteria. However, the compounds are often cytotoxic and have mild and serious toxic and side effects on human bodies. For bacteria, because antibiotics are used for a long time and are used excessively, stronger drug resistance is generated and the bacteria lose effectiveness, and new medicines are urgently required to be developed.
Disclosure of Invention
In view of the above defects or improvement needs of the prior art, the present invention aims to provide a group of food-derived polypeptides for preparing drugs for preventing and treating viral or bacterial infectious diseases, and special medical food or health care products for preventing viral or bacterial infectious diseases; moreover, the polypeptides are particularly food-borne polypeptides, the sources of the polypeptides can be food which is selected and formed by human for meeting the requirements of living and breeding offspring for a long time, and the polypeptides can avoid toxic and side reactions of human bodies when being used for preparing medicaments for preventing and treating virus or bacterial infectious diseases and special medical foods or health care products for preventing the virus or bacterial infectious diseases.
In order to achieve the above object, according to one aspect of the present invention, there is provided a use of a polypeptide for preparing a medicament for preventing and treating viral or bacterial infectious diseases, wherein an amino acid sequence of the polypeptide is represented by any one of sequences SEQ ID:1 to SEQ ID: 23.
As a further preferred aspect of the present invention, the viral infectious diseases include viral infectious diseases caused by influenza virus, coronavirus, hepatitis virus, rhinitis virus, hiv virus, or oncogenic virus;
Bacterial infectious diseases include cold, diarrhea, pneumonia, typhoid, meningitis or septicemia.
As a further preferred aspect of the present invention, the drug is an oral drug or an injectable drug.
As a further optimization of the invention, the medicine also comprises other auxiliary materials.
According to another aspect of the present invention, there is provided a medicament for preventing and treating viral or bacterial infectious diseases, characterized by comprising a polypeptide having an amino acid sequence as shown in any one of sequences SEQ ID:1 to SEQ ID: 23.
According to still another aspect of the invention, the invention provides an application of a polypeptide in preparing a special medical food or a health-care product for preventing virus or bacterial infectious diseases, wherein the amino acid sequence of the polypeptide is shown as any one of SEQ ID: 1-SEQ ID: 23.
As a further preferred mode of the invention, the special medical food or the health care product also comprises other auxiliary materials.
According to still another aspect of the present invention, there is provided a specialist food or health care product characterised by comprising a polypeptide having an amino acid sequence as shown in any one of sequences SEQ ID:1 to SEQ ID: 23.
Compared with the prior art, the technical scheme of the invention has the advantages that as a group of 23 polypeptides with amino acid sequences shown as SEQ ID: 1-SEQ ID:23 are utilized, the polypeptides can be particularly food-borne sources, namely food-borne polypeptides, and can be used for preparing medicines, special medical foods or health-care products for preventing or treating virus or bacterial infectious diseases. These polypeptides are small protein molecules formed by linking amino acids, essential nutrients for the human body, by peptide bonds, and have a molecular weight of between 250 daltons and 5000 daltons. They can also be used as nutraceuticals, providing amino acids for proteins synthesized by the human body. They can be derived from a group of compounds that are produced in vivo or in vitro unintentionally and that have a positive effect on the metabolism of the human body, by adapting the human body to the environment over a long period of time to select the food to be formed for the survival and reproduction of the offspring. The compounds are basic units hydrolyzed by protease and can stably exert their respective functions or jointly exert their combined functions in vivo. Due to the abundant element composition and various skillful matching of chemical bonds in molecules, the small molecular polypeptides can generate biochemical reaction with active substances carried by invading viruses and microorganisms in a human body to block invasion and parasitism of the viruses/bacteria.
Drawings
FIG. 1 is a schematic diagram showing growth and propagation of pathogenic cocci at 35 ℃ for 24 hours when a polypeptide (Gln-Arg-Pro-Arg) is added in example 1 of the present invention.
FIG. 2 is a pictorial representation of a comparison of the polypeptides (Gln-Arg-Pro-Arg) in example 1 of the present invention, which was made when the pathogenic coccus bacteria grew and propagated at 35 ℃ for 24 hours.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
In summary, a group of food-derived polypeptides of the invention have the following amino acid sequences:
Ala-His-Val-His；
Arg-Ala-Asp-His-Pro-Phe-Leu；
Asp-Lys-Glu-Asn；
Arg-Pro-Leu-Lys-Pro-Trp；
Arg-Gln-Arg-Lys；
Cys-Gln-Pro-Pro-Asn-Ser-Lys-Thr-Cys；
Cys-Gln-Ala-Pro-Tyr-Ser-Leu-Ala-Cys；
Gln-Arg-Pro-Arg；
His-Cys-Gln-Arg-Pro-Arg；
His-His-Leu；
Ile-Glu-Glu-Gln-Cys-Lys-Thr-Phe-Leu-Asp-Lys-Phe-Asn-His-Glu-Ala-Glu-Asp-Glu-Asp-Leu-Phe-Tyr-Gln-Ser；
Ile-Leu-Leu；
Leu-Pro-Phe；
Lys-Leu-Lys-Leu-Leu-Lys-Leu-Lys；
Leu-Leu-Leu；
Leu-Leu-Pro-His-His；
Met-Leu-Pro-Ser-Tyr-Ser-Pro-Tyr；
Tyr-Ala-Gln-Glu-Arg-Tyr-Pro-Ile-Leu；
Val-His-Ala-Asp-Gln-Asn；
Val-His-Val-Val；
Val-Ile-Lys；
Asp-Lys-Val-Gly-Ile-Asn-Tyr-Trp；
Tyr-Gly-Leu-Phe；
a total of 23 polypeptides.
The food-borne polypeptides are used for treating viral and bacterial infectious diseases, including viral infectious diseases such as influenza virus, coronavirus, hepatitis virus, rhinitis virus, HIV and oncogenic virus, and diseases caused by infection with pathogenic bacteria, such as cold, diarrhea, pneumonia, typhoid fever, meningitis, and the like. For example, a single or a combination of more than one of the above polypeptides may be used to produce a pharmaceutical product for oral administration or injection. For another example, a combination of one or more of the above polypeptides may be used to produce a specialty food or health care product. Of course, the above-mentioned single or more polypeptides may be mixed with other materials to produce a pharmaceutical product for oral administration or injection. Or, the above single or more polypeptides and other materials are mixed to make special medical food or health care product.
The following are specific examples:
example 1.
When the same Xenorcoccus was incubated with the addition of the peptide Gln-Arg-Pro-Arg (15. mu.g/ml), the bacteria grew at 35 ℃ for 24 hours and were significantly smaller than the number of colonies without the addition of this peptide (see FIG. 1, FIG. 2 for comparison).
Example 2.
2018, from winter to 2019 spring, there are influenza in kindergarten. Epidemiological investigation shows that 83 children drink the yoghourt, only 9 children suffer from cold, and the prevalence rate is 11%. 15 children who do not drink the yogurt suffer from influenza and 5 children suffer from influenza, and the incidence rate of the influenza accounts for 33%. The reason is that the yoghourt contains peptides such as Asp-Lys-Val-Gly-Ile-Asn-Tyr-Trp, Tyr-Gly-Leu-Phe, and the like which have the functions of resisting bacteria and viruses, diminishing inflammation and improving immunity.
The amino acid sequences adopted by the invention are respectively shown as the sequences SEQ ID: 1-SEQ ID:23, and the polypeptides can be particularly food-borne polypeptides, and the synthetic route can be as follows: for example, the casein of common milk contains a larger polypeptide Asn-Gly-Pro-Glu-Pro-Ser-Gly-Pro-Glu-Pro-Glu-Pro, the milk is fermented to prepare the yoghourt, and the yoghourt is hydrolyzed into small peptides such as Asn-Gly-Pro, Glu-Pro, Ser-Gly-Pro, Glu-Pro and the like under the action of lactobacillus compound protease in the processing process, so that the polypeptide is obtained in a food source manner.
It will be understood by those skilled in the art that the foregoing is only a preferred embodiment of the present invention, and is not intended to limit the invention, and that any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the scope of the present invention.
Sequence listing
<110> university of science and technology in Huazhong
<120> application of a group of food-derived polypeptides
<160>23
<170>SIPOSequenceListing 1.0
<210>1
<211>4
<212>PRT
<213> Artificial Sequence (Artificial Sequence)
<400>1
Ala His Val His
1
<210>2
<211>7
<212>PRT
<213> Artificial Sequence (Artificial Sequence)
<400>2
Arg Ala Asp His Pro Phe Leu
1 5
<210>3
<211>4
<212>PRT
<213> Artificial Sequence (Artificial Sequence)
<400>3
Asp Lys Glu Asn
1
<210>4
<211>6
<212>PRT
<213> Artificial Sequence (Artificial Sequence)
<400>4
Arg Pro Leu Lys Pro Trp
1 5
<210>5
<211>4
<212>PRT
<213> Artificial Sequence (Artificial Sequence)
<400>5
Arg Gln Arg Lys
1
<210>6
<211>9
<212>PRT
<213> Artificial Sequence (Artificial Sequence)
<400>6
Cys Gln Pro Pro Asn Ser Lys Thr Cys
1 5
<210>7
<211>9
<212>PRT
<213> Artificial Sequence (Artificial Sequence)
<400>7
Cys Gln Ala Pro Tyr Ser Leu Ala Cys
1 5
<210>8
<211>4
<212>PRT
<213> Artificial Sequence (Artificial Sequence)
<400>8
Gln Arg Pro Arg
1
<210>9
<211>6
<212>PRT
<213> Artificial Sequence (Artificial Sequence)
<400>9
His Cys Gln Arg Pro Arg
1 5
<210>10
<211>3
<212>PRT
<213> Artificial Sequence (Artificial Sequence)
<400>10
His His Leu
1
<210>11
<211>25
<212>PRT
<213> Artificial Sequence (Artificial Sequence)
<400>11
Ile Glu Glu Gln Cys Lys Thr Phe Leu Asp Lys Phe Asn His Glu Ala
1 5 10 15
Glu Asp Glu Asp Leu Phe Tyr Gln Ser
20 25
<210>12
<211>3
<212>PRT
<213> Artificial Sequence (Artificial Sequence)
<400>12
Ile Leu Leu
1
<210>13
<211>3
<212>PRT
<213> Artificial Sequence (Artificial Sequence)
<400>13
Leu Pro Phe
1
<210>14
<211>8
<212>PRT
<213> Artificial Sequence (Artificial Sequence)
<400>14
Lys Leu Lys Leu Leu Lys Leu Lys
1 5
<210>15
<211>3
<212>PRT
<213> Artificial Sequence (Artificial Sequence)
<400>15
Leu Leu Leu
1
<210>16
<211>5
<212>PRT
<213> Artificial Sequence (Artificial Sequence)
<400>16
Leu Leu Pro His His
1 5
<210>17
<211>8
<212>PRT
<213> Artificial Sequence (Artificial Sequence)
<400>17
Met Leu Pro Ser Tyr Ser Pro Tyr
1 5
<210>18
<211>9
<212>PRT
<213> Artificial Sequence (Artificial Sequence)
<400>18
Tyr Ala Gln Glu Arg Tyr Pro Ile Leu
1 5
<210>19
<211>6
<212>PRT
<213> Artificial Sequence (Artificial Sequence)
<400>19
Val His Ala Asp Gln Asn
1 5
<210>20
<211>4
<212>PRT
<213> Artificial Sequence (Artificial Sequence)
<400>20
Val His Val Val
1
<210>21
<211>3
<212>PRT
<213> Artificial Sequence (Artificial Sequence)
<400>21
Val Ile Lys
1
<210>22
<211>8
<212>PRT
<213> Artificial Sequence (Artificial Sequence)
<400>22
Asp Lys Val Gly Ile Asn Tyr Trp
1 5
<210>23
<211>4
<212>PRT
<213> Artificial Sequence (Artificial Sequence)
<400>23
Tyr Gly Leu Phe
1

Claims (8)

1. The application of the polypeptide in preparing the medicine for preventing and treating virus or bacterial infectious diseases is characterized in that the amino acid sequence of the polypeptide is shown as any one of SEQ ID: 1-SEQ ID: 23.
2. The use of claim 1, wherein the viral infectious disease comprises a viral infectious disease caused by influenza virus, coronavirus, hepatitis virus, rhinitis virus, HIV or oncogenic virus;
bacterial infectious diseases include cold, diarrhea, pneumonia, typhoid, meningitis or septicemia.
3. The use according to claim 1 or 2, wherein the medicament is an oral medicament or an injectable medicament.
4. The use of any one of claims 1 to 3, wherein the medicament further comprises other excipients.
5. A medicine for preventing and treating virus or bacterial infectious diseases is characterized by comprising polypeptide with an amino acid sequence shown as any one of SEQ ID: 1-SEQ ID: 23.
6. The application of the polypeptide in preparing the special medical food or the health-care product for preventing the virus or bacterial infectious diseases is characterized in that the amino acid sequence of the polypeptide is shown as any one of sequences SEQ ID: 1-SEQ ID: 23.
7. The use of claim 6, wherein the specialist food or health care product further comprises other excipients.
8. A special medical food or health care product is characterized by comprising polypeptide with an amino acid sequence shown as any one of SEQ ID: 1-SEQ ID: 23.
CN202010601569.9A 2020-06-28 2020-06-28 Application of food-borne polypeptides Pending CN111840510A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112656934A (en) * 2021-01-22 2021-04-16 深圳市图微安创科技开发有限公司 Application of polypeptide AT03 in medicine for treating primary biliary cholangitis

Citations (6)

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Publication number Priority date Publication date Assignee Title
JPH0692867A (en) * 1992-03-04 1994-04-05 Honen Corp Immunopotentioator
CN1582400A (en) * 2001-02-21 2005-02-16 加拿大国立研究院 Magnetic resonance spectroscopy to identify and classify microorganisms
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