CN111840487A - Traditional Chinese medicine preparation with function of improving abdominal pain and constipation and preparation method thereof - Google Patents
Traditional Chinese medicine preparation with function of improving abdominal pain and constipation and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
Abstract
The invention discloses a traditional Chinese medicine preparation with functions of improving abdominal pain and constipation and a preparation method thereof, and particularly belongs to the field of traditional Chinese medicine preparations, wherein the traditional Chinese medicine preparation comprises the following components: 20-30 parts of radix tetrastigme endophytic fungus fermentation liquor, 10-20 parts of bracteatum aqueous extract, 10-20 parts of galangal aqueous extract, 5-10 parts of fructus amomi aqueous extract, 1-5 parts of taro milling aqueous extract, 3-12 parts of calystegia chinensis aqueous extract and 7-16 parts of anthriscus sylvestris aqueous extract. The traditional Chinese medicine preparation provided by the invention has the advantages of relaxing bowels, moistening intestines, promoting the production of body fluid and relieving sore throat.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine preparation with functions of improving abdominal pain and constipation and a preparation method thereof.
Background
The main manifestations of constipation are the reduction of defecation frequency and difficulty, and many patients have defecation frequency less than 3 times per week, and in severe cases, the defecation is performed for 2-4 weeks. The constipation patients can obviously show difficult defecation, the defecation time can be more than 30 minutes, and the feces are hard like sheep feces and are few in quantity. In addition, abdominal distension, anorexia and abdominal pain before defecation due to improper administration of laxatives are also associated with the symptoms.
In order to treat or ameliorate constipation symptoms, patients often eat certain foods that promote digestion and defecation, such as yogurt, melons, fruits, vegetables, and the like. However, the food has a single nutrition function, and is not suitable for various complications caused by constipation of patients.
Disclosure of Invention
The invention provides a traditional Chinese medicine preparation with functions of improving abdominal pain and constipation, and the traditional Chinese medicine preparation has the advantages of relaxing bowels, moistening intestines, promoting fluid production and relieving sore throat.
In order to achieve the purpose, the invention provides the following technical scheme:
a traditional Chinese medicine preparation with functions of improving abdominal pain and constipation comprises the following components in parts by weight:
20-30 parts of radix tetrastigme endophytic fungus fermentation liquor, 10-20 parts of bracteatum aqueous extract, 10-20 parts of galangal aqueous extract, 5-10 parts of fructus amomi aqueous extract, 1-5 parts of taro milling aqueous extract, 3-12 parts of calystegia chinensis aqueous extract and 7-16 parts of anthriscus sylvestris aqueous extract.
Preferably, the radix tetrastigme endophytic fungi fermentation liquor is obtained by culturing endophytic fungi separated from leaves of clivia trifoliata of the genus clivia of the family vitidae, the classification name of the radix tetrastigme endophytic fungi is Penicillium pimiteouiense, and the strain preservation number is as follows: CGMCC No.17664, the preservation time of the strain is 2019, 4 months and 30 days, and the preservation address of the strain is as follows: the institute of microbiology, national academy of sciences No. 3, Xilu No.1, Beijing, Chaoyang, Beijing. The preservation unit: china general microbiological culture Collection center.
Preferably, the Chinese medicinal preparation further comprises one of an aqueous extract of May tea, an aqueous extract of Ardisia pulvinata, an aqueous extract of Ledum gracilis and an aqueous extract of Caesalpinia crista, or a mixture thereof.
Preferably, the traditional Chinese medicine preparation comprises the following components:
20-30 parts of radix tetrastigme endophytic fungus fermentation liquor, 10-20 parts of bracteatum aqueous extract, 10-20 parts of galangal aqueous extract, 5-10 parts of fructus amomi aqueous extract, 1-5 parts of taro milling aqueous extract, 3-12 parts of calyx canthus flower aqueous extract, 7-16 parts of anthriscus sylvestris aqueous extract, 1-4 parts of May tea aqueous extract, 1-2 parts of Pteris polymorpha aqueous extract, 1-2 parts of pistil gynura aqueous extract and 1-2 parts of Caesalpinia rostrata aqueous extract.
Preferably, the traditional Chinese medicine preparation comprises the following components:
25 parts of radix tetrastigme endophytic fungus fermentation liquor, 15 parts of bracteatum aqueous extract, 15 parts of galangal aqueous extract, 7 parts of fructus amomi aqueous extract, 3 parts of taro milling aqueous extract, 8 parts of anemone dichotoma aqueous extract, 12 parts of anthriscus sylvestris aqueous extract, 3 parts of pubescent holly aqueous extract, 1.5 parts of multivein ardisia japonica aqueous extract, 1.5 parts of thesium nigricans aqueous extract and 1 part of caesalpinia subrupr aqueous extract.
The invention provides a preparation method of a traditional Chinese medicine preparation with functions of improving abdominal pain and constipation, which comprises the following steps:
S01, taking bracteal vine, galangal fruit, amomum fruit, ground taro, garden burnet, anthriscus sylvestris, Maackia pubescens, Maackia yunnanensis, Domai ardisia japonica, Heimai hao and Caesalpinia crista by weight parts, adding water, grinding into slurry, and obtaining first mixed slurry.
S02, adding the radix tetrastigme endophytic fungi fermentation liquid and purified water into the prepared first mixed slurry, and uniformly stirring after mixing to obtain second mixed slurry.
And S03, adding the second mixed slurry into a high-pressure jet mill, and carrying out jet flow superfine grinding treatment under the pressure condition of 60-80 MPa to obtain the important preparation.
Preferably, in step S03, the pressure condition is 70 MPa.
Preferably, in step S02, the mass ratio of the first mixed slurry, the radix tetrastigme endophytic fungi fermentation broth and the purified water added is 1: 5: 7.
the invention has the beneficial effects that:
in the invention, the radix tetrastigme endophytic fungi fermentation liquor, the bracteatum aqueous extract, the galangal fruit aqueous extract and other plant source components with the functions of promoting treatment of abdominal pain and promoting defecation to disappear are added into the formula, so that the symptoms of constipation and abdominal pain can be effectively improved, the immunity of eaters can be enhanced, and other complications caused by abdominal stools can be prevented. Meanwhile, as the components adopt plant source components, the safety of food sources can be greatly ensured, and the occurrence of side effects caused by long-term eating is avoided.
Detailed Description
Example 1
A traditional Chinese medicine preparation with functions of improving abdominal pain and constipation comprises the following components in parts by weight:
20 parts of radix tetrastigme endophytic fungus fermentation liquor, 10 parts of bracteatum aqueous extract, 10 parts of galangal aqueous extract, 5 parts of fructus amomi aqueous extract, 1 part of taro milling aqueous extract, 3 parts of anemone dichotoma aqueous extract, 7 parts of anthriscus sylvestris aqueous extract, 1 part of pubescent holly leaf aqueous extract, 1 part of radix ceratis multiceps aqueous extract, 1 part of thesium nigricans aqueous extract and 1 part of caesalpinia subulata aqueous extract.
The preparation method of the traditional Chinese medicine preparation comprises the following steps:
s01, taking a preset weight part of bracteal vine, galangal fruit, amomum fruit, grinding taro, breaking calanthe, anthriscus sylvestris, May tea, Ardisia pulcherrima, kalimeris indica and Caesalpinia rhynchophylla, adding water, grinding into slurry to obtain a first mixed slurry;
s02, adding the radix tetrastigme endophytic fungi fermentation liquid and purified water into the prepared first mixed slurry, and uniformly stirring after mixing to obtain second mixed slurry. The mass ratio of the added first mixed slurry, the radix tetrastigme endophytic fungi fermentation broth and the purified water is 1: 5: 7.
and S03, adding the second mixed slurry into a high-pressure jet mill, and carrying out jet flow superfine grinding treatment under the pressure condition of 70MPa to obtain the important preparation.
Example 2
A traditional Chinese medicine preparation with functions of improving abdominal pain and constipation comprises the following components in parts by weight:
25 parts of radix tetrastigme endophytic fungus fermentation liquor, 15 parts of bracteatum aqueous extract, 15 parts of galangal aqueous extract, 7 parts of fructus amomi aqueous extract, 3 parts of taro milling aqueous extract, 8 parts of anemone dichotoma aqueous extract, 12 parts of anthriscus sylvestris aqueous extract, 3 parts of pubescent holly aqueous extract, 1.5 parts of multivein ardisia japonica aqueous extract, 1.5 parts of thesium nigricans aqueous extract and 1 part of caesalpinia subrupr aqueous extract.
The preparation method of the traditional Chinese medicine preparation is the same as that of example 1.
Example 3
A traditional Chinese medicine preparation with functions of improving abdominal pain and constipation comprises the following components in parts by weight:
27 parts of radix tetrastigme endophytic fungus fermentation liquor, 18 parts of bracteatum aqueous extract, 16 parts of galangal aqueous extract, 8 parts of fructus amomi aqueous extract, 4 parts of taro milling aqueous extract, 10 parts of anemone dichotoma aqueous extract, 13 parts of anthriscus sylvestris aqueous extract, 3 parts of pubescent holly aqueous extract, 2 parts of multivein ardisia japonica aqueous extract, 2 parts of thesium nigricans aqueous extract and 2 parts of caesalpinia subulata aqueous extract.
The preparation method of the traditional Chinese medicine preparation is the same as that of example 1.
Example 4
A traditional Chinese medicine preparation with functions of improving abdominal pain and constipation comprises the following components in parts by weight:
30 parts of radix tetrastigme endophytic fungi fermentation liquor, 20 parts of a bracteatum aqueous extract, 20 parts of a galangal aqueous extract, 10 parts of a fructus amomi aqueous extract, 5 parts of a taro milling aqueous extract, 12 parts of a flower of panicled swallowwort flower aqueous extract, 16 parts of an anthriscus sylvestris aqueous extract, 4 parts of a May tea aqueous extract, 2 parts of a multi-vein ardisia japonica aqueous extract, 2 parts of a black pistil water extract and 2 parts of a caesalpinia rostrata aqueous extract.
The preparation method of the traditional Chinese medicine preparation is the same as that of example 1.
Claims (8)
1. A traditional Chinese medicine preparation with functions of improving abdominal pain and constipation is characterized by comprising the following components in parts by weight:
20-30 parts of radix tetrastigme endophytic fungus fermentation liquor, 10-20 parts of bracteatum aqueous extract, 10-20 parts of galangal aqueous extract, 5-10 parts of fructus amomi aqueous extract, 1-5 parts of taro milling aqueous extract, 3-12 parts of calystegia chinensis aqueous extract and 7-16 parts of anthriscus sylvestris aqueous extract.
2. The Chinese medicinal preparation for improving abdominal pain and constipation according to claim 1, wherein the radix tetrastigme endophytic fungus fermentation broth is obtained by culturing endophytic fungi separated from leaves of adinandra nitida belonging to the genus adinandra of the family Vitaceae, and the classification name of the radix tetrastigme endophytic fungi is TH01, and the strain deposit number is: CGMCC No. 17664.
3. The Chinese medicinal preparation for relieving abdominal pain and constipation according to claim 1, further comprising one of May tea extract, Ardisia polymorpha extract, Carica nigra extract, and Caesalpinia coracoides extract, or a mixture thereof.
4. The traditional Chinese medicine preparation with the function of improving abdominal pain and constipation according to any one of claims 1 to 3, which comprises the following components in parts by weight:
20-30 parts of radix tetrastigme endophytic fungus fermentation liquor, 10-20 parts of bracteatum aqueous extract, 10-20 parts of galangal aqueous extract, 5-10 parts of fructus amomi aqueous extract, 1-5 parts of taro milling aqueous extract, 3-12 parts of calyx canthus flower aqueous extract, 7-16 parts of anthriscus sylvestris aqueous extract, 1-4 parts of May tea aqueous extract, 1-2 parts of Pteris polymorpha aqueous extract, 1-2 parts of pistil gynura aqueous extract and 1-2 parts of Caesalpinia rostrata aqueous extract.
5. The traditional Chinese medicine preparation with the function of improving abdominal pain and constipation according to claim 4, which is characterized by comprising the following components in parts by weight:
25 parts of radix tetrastigme endophytic fungus fermentation liquor, 15 parts of bracteatum aqueous extract, 15 parts of galangal aqueous extract, 7 parts of fructus amomi aqueous extract, 3 parts of taro milling aqueous extract, 8 parts of anemone dichotoma aqueous extract, 12 parts of anthriscus sylvestris aqueous extract, 3 parts of pubescent holly aqueous extract, 1.5 parts of multivein ardisia japonica aqueous extract, 1.5 parts of thesium nigricans aqueous extract and 1 part of caesalpinia subrupr aqueous extract.
6. A preparation method of a traditional Chinese medicine preparation with the function of improving abdominal pain and constipation is characterized by comprising the following steps:
s01, taking a preset weight part of bracteal vine, galangal fruit, amomum fruit, grinding taro, breaking calanthe, anthriscus sylvestris, May tea, Ardisia pulcherrima, kalimeris indica and Caesalpinia rhynchophylla, adding water, grinding into slurry to obtain a first mixed slurry;
s02, adding radix tetrastigme endophytic fungus fermentation liquor and purified water into the prepared first mixed slurry, and uniformly stirring after mixing to obtain second mixed slurry;
and S03, adding the second mixed slurry into a high-pressure jet mill, and carrying out jet flow superfine grinding treatment under the pressure condition of 60-80 MPa to obtain the important preparation.
7. The method of claim 6, wherein in step S03, the pressure is 70 MPa.
8. The method for preparing a Chinese medicinal preparation for relieving abdominal pain and constipation according to claim 7, wherein the first mixed slurry, the radix tetrastigme endophytic fungi fermentation broth and the purified water are added in step S02 in a mass ratio of 1: 5: 7.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114452340A (en) * | 2022-03-21 | 2022-05-10 | 朱建国 | Radix tetrastigme tablet for improving intestinal microecology |
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2020
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| CN108586626A (en) * | 2018-04-04 | 2018-09-28 | 浙江中医药大学 | A kind of preparation method and applications of radix tetrastigme oligosaccharide |
| CN108271894A (en) * | 2018-04-19 | 2018-07-13 | 何裕泉 | A kind of nourishing and protecting liver tea and preparation method thereof |
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Application publication date: 20201030 |