CN111840077A - Preparation method and production equipment of organic acid tablets - Google Patents
Preparation method and production equipment of organic acid tablets Download PDFInfo
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- CN111840077A CN111840077A CN202010571630.XA CN202010571630A CN111840077A CN 111840077 A CN111840077 A CN 111840077A CN 202010571630 A CN202010571630 A CN 202010571630A CN 111840077 A CN111840077 A CN 111840077A
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- acid tablet
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- 150000007524 organic acids Chemical class 0.000 title claims abstract description 61
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title abstract description 9
- 239000000463 material Substances 0.000 claims description 56
- 238000003825 pressing Methods 0.000 claims description 46
- 239000000110 cooling liquid Substances 0.000 claims description 25
- 239000002994 raw material Substances 0.000 claims description 18
- 238000003860 storage Methods 0.000 claims description 17
- 238000007599 discharging Methods 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 12
- 230000000712 assembly Effects 0.000 claims description 9
- 238000000429 assembly Methods 0.000 claims description 9
- 238000002955 isolation Methods 0.000 claims description 7
- 238000004080 punching Methods 0.000 claims description 7
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 6
- 239000004615 ingredient Substances 0.000 claims description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 6
- 230000005540 biological transmission Effects 0.000 claims description 4
- 238000005469 granulation Methods 0.000 claims description 4
- 230000003179 granulation Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 108010011485 Aspartame Proteins 0.000 claims description 3
- 235000005976 Citrus sinensis Nutrition 0.000 claims description 3
- 240000002319 Citrus sinensis Species 0.000 claims description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 3
- 229930003268 Vitamin C Natural products 0.000 claims description 3
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 3
- 229960003438 aspartame Drugs 0.000 claims description 3
- 235000010357 aspartame Nutrition 0.000 claims description 3
- 239000000605 aspartame Substances 0.000 claims description 3
- 239000011230 binding agent Substances 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 239000008101 lactose Substances 0.000 claims description 3
- 239000000314 lubricant Substances 0.000 claims description 3
- 235000019359 magnesium stearate Nutrition 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 229910021487 silica fume Inorganic materials 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 235000019154 vitamin C Nutrition 0.000 claims description 3
- 239000011718 vitamin C Substances 0.000 claims description 3
- 230000000149 penetrating effect Effects 0.000 claims description 2
- 238000012545 processing Methods 0.000 abstract description 6
- 238000004383 yellowing Methods 0.000 abstract description 4
- 238000013461 design Methods 0.000 abstract description 3
- 239000003826 tablet Substances 0.000 description 66
- 238000000034 method Methods 0.000 description 12
- 239000003814 drug Substances 0.000 description 8
- 238000005457 optimization Methods 0.000 description 6
- 239000002826 coolant Substances 0.000 description 4
- 239000006189 buccal tablet Substances 0.000 description 2
- 239000007938 effervescent tablet Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
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- 238000011160 research Methods 0.000 description 2
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- 238000004026 adhesive bonding Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229940046011 buccal tablet Drugs 0.000 description 1
- 239000007910 chewable tablet Substances 0.000 description 1
- 229940068682 chewable tablet Drugs 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000005034 decoration Methods 0.000 description 1
- 239000007919 dispersible tablet Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000002662 enteric coated tablet Substances 0.000 description 1
- 239000010685 fatty oil Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 229940023488 pill Drugs 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000006190 sub-lingual tablet Substances 0.000 description 1
- 229940098466 sublingual tablet Drugs 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 238000009492 tablet coating Methods 0.000 description 1
- 239000002700 tablet coating Substances 0.000 description 1
- 239000000003 vaginal tablet Substances 0.000 description 1
- 229940044977 vaginal tablet Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J2200/00—General characteristics or adaptations
- A61J2200/40—Heating or cooling means; Combinations thereof
- A61J2200/44—Cooling means
Abstract
The invention discloses a preparation method and production equipment of an organic acid tablet, and relates to the technical field of production of the organic acid tablet. The equipment provided by the invention is scientific in design and convenient to use, meets the production and processing requirements of large-scale organic acid tablets of enterprises, can prevent the phenomenon of sticking a punch head, improves the processing quality of the organic acid tablets, can avoid the phenomenon of yellowing of the processed organic acid tablets, reduces the rejection rate, and improves the appearance forming quality of products.
Description
Technical Field
The invention relates to the technical field of organic acid tablet production, in particular to a preparation method and production equipment of an organic acid tablet.
Background
The tablet is a flaky or specially-shaped flaky solid preparation which is prepared by uniformly mixing the medicament and auxiliary materials and then pressing. The tablet is mainly an oral common tablet, and also comprises a buccal tablet, a sublingual tablet, an oral patch, a chewable tablet, a dispersible tablet, an effervescent tablet, a vaginal tablet, a quick-release or sustained-release or controlled-release tablet, an enteric-coated tablet and the like, the tablet is developed on the basis of pill use, the tablet is created and used in the 40 s of the nineteenth century, the production and the application of the tablet are rapidly developed along with the appearance and continuous improvement of a tabletting machine in the end of the 19 th century, and the production technology and the mechanical equipment of the tablet are greatly developed in recent decades, such as boiling granulation, full-powder direct tabletting, half-film coating, new auxiliary materials, new processes, production linkage and the like. The research and production of the traditional Chinese medicine tablets are started only in 50 years, along with the comprehensive research of the aspects of chemistry, pharmacology, preparation and clinic of traditional Chinese medicine, the varieties and the number of the traditional Chinese medicine tablets are continuously increased, the process technology is improved day by day, the quality of the tablets is gradually improved, the types of the traditional Chinese medicine tablets are not only common compressed tablets, sugar-coated tablets, but also micro-capsules, buccal tablets, external tablets, effervescent tablets and the like, a set of process conditions suitable for the production of the traditional Chinese medicine tablets are gradually found out in the aspect of the production process of the tablets, for example, for the preparation of the tablets containing fatty oil and volatile oil, the experience of improving the hardness of the traditional Chinese medicine tablets, improving the disintegration degree, gradually accumulating the tablet coating and the like is. In addition, studies on the dissolution rate and bioavailability of drugs in the Chinese medicinal tablet have been gradually conducted. In a word, the existing tablet has become one of the dosage forms with multiple varieties, large output, wide application, convenient use, storage and transportation and stable quality.
At present, there is sticky drift phenomenon in current organic acid tablet in the course of working, there is a period of back of operation in the tablet press on the market, the drift generates heat, thereby the high temperature in the tablet press makes the raw materials appear gluing the drift at the preforming in-process, not only cause the mechanical fault of tablet press easily, influence production progress and production efficiency, the processingquality of organic acid tablet is uneven, the yellowing phenomenon appears in the organic acid tablet that processes out, the appearance shaping quality is poor, product surface quality is low, be difficult to satisfy the manufacturing demand of the big batch organic acid tablet of enterprise, need to improve urgently.
Disclosure of Invention
The invention aims to solve the problems, provides a preparation method and production equipment of organic acid tablets, has scientific integral design and convenient use, meets the production and processing requirements of large-scale organic acid tablets of enterprises, can effectively prevent punch sticking, can reduce the failure rate of equipment, improves the production quality and the processing quality of the organic acid tablets, can avoid the yellowing phenomenon of the processed organic acid tablets, reduces the rejection rate and improves the appearance forming quality of products.
In order to realize the purpose, the invention adopts the technical scheme that: an organic acid tablet production device comprises a machine box body and a support frame, wherein a feeding mechanism used for conveying organic acid tablet raw materials is arranged at the upper end of the machine box body, an upper rotary table and a lower rotary table are arranged in the machine box body and below the feeding mechanism, the upper rotary table and the lower rotary table are parallel to each other and are fixed on a driven rotating shaft, material pressing dies are arranged in the upper rotary table in an annular array manner, hydraulic cylinders are arranged above the material pressing dies and on the inner wall of the top of the machine box body, the output shaft ends of the hydraulic cylinders are provided with upper pressing heads matched with the inner diameter of the material pressing dies, lower pressing head assemblies matched with the upper pressing heads for pressing materials are arranged in the material pressing dies, and unloading assemblies are arranged below the lower pressing head assemblies and; one end of the driven rotating shaft penetrating through the case body is provided with a driven gear, the driven gear is in meshing transmission with a driving gear on the driving rotating shaft, and the driving rotating shaft is connected with the output shaft end of the servo motor.
The feeding mechanism comprises a vacuum feeding machine, the output end of the vacuum feeding machine is connected with a feeding pipe, the other end of the feeding pipe extends into the machine box and is arranged above the material pressing die, a cooling liquid conveying pipe is spirally wound on the outer wall of the feeding pipe, one end of the cooling liquid conveying pipe is communicated with the lower end of a cooling liquid storage tank, the other end of the cooling liquid conveying pipe is connected with the input end of a circulating liquid pump, the output end of the circulating liquid pump is connected with the upper end of the cooling liquid storage tank, and a control valve is arranged on the cooling liquid conveying pipe.
As a further optimization of the invention, the outer part of the feeding pipe and the inner wall of the top of the machine box body are connected with a supporting shell through a first connecting bolt, and the lower end of the supporting shell is movably provided with a material guide funnel for guiding the organic acid tablet raw material into the material pressing mold.
As a further optimization of the invention, the material guide funnel is in a conical funnel cavity structure, the lower surface of a boss at the side part of the material guide funnel is provided with a guide rod body, the guide rod body downwards penetrates through the bottom of the supporting shell, a first spring is arranged on the guide rod body and between the supporting shell and the material guide funnel, and the upper surface of the side end of the material guide funnel, which extends out of the supporting shell, is provided with a vibration motor.
As a further optimization of the invention, the lower punch assembly comprises a lower punch and a punch rod body which are movably arranged in the pressing die, the lower end part of the punch rod body is fixed at the center of the top of the connecting disc, the bottom of the connecting disc is provided with a fixed rod body in the discharging assembly in an annular array mode, the fixed rod body penetrates through the lower rotary disc downwards, and a second spring is arranged between the lower rotary disc and the connecting disc and on the fixed rod body.
As a further optimization of the invention, the pressing die is arranged in the upper rotary table through a first connecting key, and the bottom of the upper rotary table is connected with the isolation sleeve through a second connecting bolt.
As further optimization of the invention, the driven rotating shaft is connected with the driven gear through a second connecting key, the driving rotating shaft is connected with the driving gear through a third connecting key, and a bearing is arranged between the driven rotating shaft and the case body.
As a further optimization of the invention, the support frame is provided with a fan, the output end of the fan is connected with an air pipe, the air pipe extends into the case body of the machine, the side wall of the case body is provided with a discharge pipe opposite to the air outlet of the air pipe, and the lower end of the discharge pipe is provided with a storage case body for storing organic acid tablets.
A method for producing organic acid tablets by using organic acid tablet production equipment comprises the following ingredients in parts by weight: 12 parts of vitamin C; 34 parts of sodium bicarbonate; 7 parts of sodium carboxymethyl starch; 13 parts of lactose; 1.4 parts of aspartame; 1.1 parts of sweet orange essence; 1 part of micro silica gel powder; 0.5 part of magnesium stearate, adding 304 parts of polyvinylpyrrolidone-K as a binding agent into the ingredients for granulation, drying and cooling, adding 60001 parts of polyethylene glycol as a lubricating agent, uniformly mixing, and feeding into organic acid tablet production equipment for tabletting to obtain the organic acid tablets.
The invention has the beneficial effects that: the invention provides a preparation method and production equipment of organic acid tablets, which have scientific integral design and convenient use, meet the production and processing requirements of enterprises on large-scale organic acid tablets, can effectively prevent punch sticking, reduce the equipment failure rate, improve the production quality and the processing quality of the organic acid tablets, avoid the yellowing phenomenon of the processed organic acid tablets, reduce the rejection rate and improve the product appearance forming quality.
1. The invention is provided with a feeding mechanism, wherein the feeding mechanism comprises a vacuum feeding machine, a feeding pipe, a cooling liquid conveying pipe, a control valve, a cooling liquid storage tank, a liquid conveying pipeline and a circulating liquid pump, the cooling liquid is stored in the cooling liquid storage tank, the control valve is opened to drive the circulating liquid pump, the cooling liquid is circularly conveyed in the cooling liquid conveying pipe spirally wound on the outer wall of the feeding pipe, the temperature of raw materials entering a material pressing die is reduced, and the phenomenon that the raw materials are stuck to a punch head due to overhigh temperature in the subsequent tabletting operation process is avoided.
2. The material guide hopper is provided with the material guide hopper and the vibration motor, the vibration motor is driven to drive the material guide hopper to shake, raw materials can quickly enter the material pressing die from the lower end part of the material guide hopper, the raw materials are prevented from being detained at the lower end part of the material guide hopper and blocking a discharge hole, and the overall practicability and stability of the device are improved.
3. The invention is provided with a lower punch assembly and a discharging assembly, wherein the upper punch and the lower punch are matched in a material pressing die to press raw materials into sheets, a second spring in the discharging assembly is continuously compressed along with the downward pressing operation of the upper punch in the material pressing die, the pressure provided by the lower punch to the lower surface of a tablet forming material is also continuously increased, so that the tablet forming quality is better, and after the tablet forming operation is finished, the second spring pushes the lower punch assembly to move upwards to push the pressed organic acid tablet forming material out of the material pressing die, so that the discharging operation is realized.
4. The invention is provided with the isolation sleeve, so that the pressed organic acid tablets can be effectively prevented from entering between the upper rotary disc and the lower rotary disc.
5. The invention is provided with the fan and the air pipe, the fan is driven to blow out wind power from the air pipe, and the pressed organic acid tablets are sent into the storage box body from the position of the discharge pipe for storage.
Drawings
Fig. 1 is a schematic front view of the present invention.
FIG. 2 is a schematic view of the position of the feeding mechanism of the present invention.
FIG. 3 is a schematic view of the structure of the material pressing mold according to the present invention.
FIG. 4 is a schematic cross-sectional view taken at A-A in FIG. 1.
Fig. 5 is a partially enlarged view of the portion B in fig. 4.
The text labels in the figures are represented as: 1. a case body; 2. a feeding mechanism; 3. a hydraulic cylinder; 4. a fan; 5. an upper turntable; 6. pressing a material die; 7. a lower ram assembly; 8. a discharge assembly; 9. a lower turntable; 10. a driven rotating shaft; 11. a servo motor; 12. a storage box body; 101. a support frame; 102. a fixed mount; 103. a discharge pipe; 201. a vacuum feeding machine; 202. a feed pipe; 203. a coolant delivery pipe; 204. a control valve; 205. a coolant storage tank; 206. a fluid delivery conduit; 207. a circulating liquid pump; 208. a support housing; 209. a material guide hopper; 210. a guide rod body; 211. a first spring; 212. vibrating a motor; 213. a first connecting bolt; 301. an upper punch head; 401. an air duct; 501. a second connecting bolt; 502. an isolation sleeve; 601. a first connecting key; 701. a lower punch head; 702. punching the rod body; 703. a connecting disc; 801. fixing the rod body; 802. a second spring; 1001. a bearing; 1002. a driven gear; 1003. a second connecting key; 1101. a driving gear; 1102. a third connecting key; 1103. the active shaft.
Detailed Description
The following detailed description of the present invention is given for the purpose of better understanding technical solutions of the present invention by those skilled in the art, and the present description is only exemplary and explanatory and should not be construed as limiting the scope of the present invention in any way.
As shown in fig. 1 to 5, the specific structure of the present invention is: the machine comprises a machine box body 1 and a support frame 101, wherein a feeding mechanism 2 used for conveying organic acid tablet raw materials is arranged at the upper end of the machine box body 1, an upper rotary table 5 and a lower rotary table 9 are arranged in the machine box body 1 and below the feeding mechanism 2, the upper rotary table 5 and the lower rotary table 9 are mutually parallel and are fixed on a driven rotating shaft 10, material pressing dies 6 are arranged in the upper rotary table 5 in an annular array mode, hydraulic cylinders 3 are arranged above the material pressing dies 6 and on the inner wall of the top of the machine box body 1, upper punching heads 301 matched with the inner diameters of the material pressing dies 6 are arranged at the output shaft ends of the hydraulic cylinders 3, lower punching head assemblies 7 matched with the upper punching heads 301 for pressing materials are arranged in the material pressing dies 6, and discharging assemblies 8 are arranged below the lower punching head assemblies 7; the one end that driven shaft 10 passed machine box 1 is provided with driven gear 1002, driven gear 1002 and the driving gear 1101 meshing transmission on the initiative pivot 1103, initiative pivot 1103 is connected with servo motor 11 output shaft end, drive hydraulic cylinder 3, hydraulic cylinder 3 drives upper punch 301 and lower punch subassembly 7 and cooperatees, carry out the preforming operation to the raw materials in pressing swage 6, drive servo motor 11, through the meshing transmission effect of driving gear 1101 with driven gear 1002, can make and go up carousel 5 and the rotatory certain angle of lower carousel 9, the material carries out pay-off and preforming operation in proper order on last carousel 5.
Preferably, in order to realize that the organic acid tablet raw material is fed into the material pressing die 6, the feeding mechanism 2 comprises a vacuum feeding machine 201, the vacuum feeding machine 201 can be a feeding machine with a model of ZKS-1, an electric power of 1.5KW, and a conveying capacity of 400Kg/h to meet the manufacturing requirement, the output end of the vacuum feeding machine 201 is connected with a feeding pipe 202, the other end of the feeding pipe 202 extends into the machine box 1 and is arranged above the material pressing die 6, a cooling liquid conveying pipe 203 is spirally wound on the outer wall of the feeding pipe 202, one end of the cooling liquid conveying pipe 203 is communicated with the lower end of a cooling liquid storage tank 205, the other end of the cooling liquid conveying pipe 203 is connected with the input end of a circulating liquid pump 207, the output end of the circulating liquid pump 207 is connected with the upper end of the cooling liquid storage tank 205, a control valve 204 is arranged on the cooling liquid conveying pipe 203, cooling liquid, drive circulation drawing liquid pump 207, coolant conveying pipe 203 inner loop that conveying pipe 202 outer wall spiral winding set up carries the coolant liquid, reduces the temperature when the raw materials gets into in the pressure material mould 6, avoids in the follow-up preforming operation process, because the high temperature leads to the raw materials to glue the drift phenomenon.
Preferably, in order to effectively and accurately guide the material into the pressing mold 6, the feeding pipe 202 is connected to a supporting housing 208 through a first connecting bolt 213 on the inner wall of the top of the housing 1, and a material guiding funnel 209 for guiding the organic acid tablet material into the pressing mold 6 is movably disposed at the lower end of the supporting housing 208.
Preferably, in order to prevent effectively that the material from piling up under guide funnel 209, guide funnel 209 is toper funnel cavity structure, guide funnel 209 lateral part boss lower surface is provided with the guide rod body 210, the guide rod body 210 passes support housing 208 bottom downwards, on the guide rod body 210 and be provided with first spring 211 between support housing 208 and guide funnel 209, the side upper surface that guide funnel 209 stretches out support housing 208 sets up vibrating motor 212, drive vibrating motor 212 can drive guide funnel 209 and shake, can make the raw materials get into in the pressure material mould 6 from guide funnel 209 tip down fast, prevent that the raw materials from being detained and blockking up the discharge gate under guide funnel 209, improve the holistic practicality and the stability of device.
Preferably, in order to facilitate the realization of the improvement of the forming quality of the organic acid tablet, the lower punch assembly 7 comprises a lower punch 701 and a punch rod body 702 movably arranged in the punch die 6, the lower end part of the punch rod body 702 is fixed at the center of the top of the connecting disc 703, the bottom of the connecting disc 703 is provided with a fixed rod body 801 in the discharging assembly 8 in an annular array, the fixed rod body 801 downwards passes through the lower rotary disc 9, a second spring 802 is arranged between the lower rotary disc 9 and the connecting disc 703 and on the fixed rod body 801, the upper punch 301 and the lower punch 701 are matched in the punch die 6 to press the raw material into a sheet shape, the second spring 802 in the discharging assembly 8 is continuously compressed along with the downward pressing operation of the upper punch 301 in the punch die 6, the pressure provided by the lower punch 701 to the lower surface of the tablet forming material is also continuously increased, so that the tablet forming quality is better, after the sheet forming operation is completed, the second spring, and pushing the pressed organic acid tablet forming material out of the pressing die 6 to realize the unloading operation.
Preferably, in order to prevent the compressed organic acid tablets from entering between the upper rotating disk 5 and the lower rotating disk 9, the swaging die 6 is arranged in the upper rotating disk 5 through the first connecting key 601, the bottom of the upper rotating disk 5 is connected with the isolation sleeve 502 through the second connecting bolt 501, and the isolation sleeve 502 plays an isolation role.
Preferably, in order to be favorable to realizing that the upper rotary table 5 and the lower rotary table 9 are driven to rotate, the whole device is pressed into sheets, the driven rotating shaft 10 is connected with the driven gear 1002 through the second connecting key 1003, the driving rotating shaft 1103 is connected with the driving gear 1101 through the third connecting key 1102, and a bearing 1001 is arranged between the driven rotating shaft 10 and the case body 1.
Preferably, in order to be favorable to realizing sending the organic acid tablet of compression molding out of the machine box body 1, be provided with fan 4 on the support frame 101, the tuber pipe 401 is connected to fan 4 output, tuber pipe 401 stretches into in the machine box body 1, be provided with discharging pipe 103 on the machine box body 1 lateral wall and opposite in tuber pipe 401 air outlet, discharging pipe 103 lower extreme is provided with the storage box body 12 that is used for saving the organic acid tablet, drive fan 4, blow off wind-force in the tuber pipe 401, the organic acid tablet that the suppression is good is sent into storage box body 12 from discharging pipe 103 position and is stored, in addition, the wind-force that fan 4 blew off can also the effectual temperature that reduces in the machine box body 1, improve the processingquality in the whole.
A method for producing organic acid tablets by using organic acid tablet production equipment comprises the following ingredients in parts by weight: 12 parts of vitamin C; 34 parts of sodium bicarbonate; 7 parts of sodium carboxymethyl starch; 13 parts of lactose; 1.4 parts of aspartame; 1.1 parts of sweet orange essence; 1 part of micro silica gel powder; 0.5 part of magnesium stearate, adding 304 parts of polyvinylpyrrolidone-K as a binding agent into the ingredients for granulation, drying and cooling, adding 60001 parts of polyethylene glycol as a lubricating agent, uniformly mixing, and feeding into organic acid tablet production equipment for tabletting to obtain the organic acid tablets.
It should be noted that, in this document, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
The principles and embodiments of the present invention are explained herein using specific examples, which are presented only to assist in understanding the method and its core concepts of the present invention. The foregoing is only a preferred embodiment of the present invention, and it should be noted that there are objectively infinite specific structures due to the limited character expressions, and it will be apparent to those skilled in the art that a plurality of modifications, decorations or changes may be made without departing from the principle of the present invention, and the technical features described above may be combined in a suitable manner; such modifications, variations, combinations, or adaptations of the invention using its spirit and scope, as defined by the claims, may be directed to other uses and embodiments.
Claims (9)
1. The organic acid tablet production equipment is characterized by comprising a machine box body (1) and a support frame (101), wherein a feeding mechanism (2) used for conveying an organic acid tablet raw material is arranged at the upper end of the machine box body (1), an upper rotary table (5) and a lower rotary table (9) are arranged inside the machine box body (1) and below the feeding mechanism (2), the upper rotary table (5) and the lower rotary table (9) are parallel to each other and are fixed on a driven rotating shaft (10), material pressing molds (6) are arranged in the upper rotary table (5) in an annular array mode, hydraulic cylinders (3) are arranged above the material pressing molds (6) and on the inner wall of the top of the machine box body (1), upper pressing heads (301) matched with the inner diameter of the material pressing molds (6) are arranged at the output shaft ends of the hydraulic cylinders (3), lower pressing head assemblies (7) matched with the upper pressing heads (301) are arranged inside the material pressing molds (6), and discharging assemblies (8) are arranged below the lower pressing head assemblies (7) and on the lower rotary table; one end of the driven rotating shaft (10) penetrating through the case body (1) is provided with a driven gear (1002), the driven gear (1002) is in meshing transmission with a driving gear (1101) on the driving rotating shaft (1103), and the driving rotating shaft (1103) is connected with an output shaft end of the servo motor (11).
2. The organic acid tablet production equipment according to claim 1, wherein the feeding mechanism (2) comprises a vacuum feeding machine (201), the output end of the vacuum feeding machine (201) is connected with a feeding pipe (202), the other end of the feeding pipe (202) extends into the machine box body (1) and is arranged above the pressing die (6), a cooling liquid conveying pipe (203) is spirally wound on the outer wall of the feeding pipe (202), one end of the cooling liquid conveying pipe (203) is communicated with the lower end of the cooling liquid storage tank (205), the other end of the cooling liquid conveying pipe (203) is connected with the input end of a circulating liquid pump (207), the output end of the circulating liquid pump (207) is connected with the upper end of the cooling liquid storage tank (205), and a control valve (204) is arranged on the cooling liquid conveying pipe (203).
3. The organic acid tablet production equipment according to claim 2, wherein a support shell (208) is connected to the outer part of the feeding pipe (202) and the inner wall of the top of the machine box body (1) through a first connecting bolt (213), and a guide funnel (209) for guiding the organic acid tablet raw materials into the material pressing die (6) is movably arranged at the lower end of the support shell (208).
4. The organic acid tablet production equipment according to claim 3, wherein the material guide funnel (209) is of a conical funnel cavity structure, a guide rod body (210) is arranged on the lower surface of a boss at the side part of the material guide funnel (209), the guide rod body (210) penetrates through the bottom of the support shell (208) downwards, a first spring (211) is arranged on the guide rod body (210) and between the support shell (208) and the material guide funnel (209), and a vibrating motor (212) is arranged on the upper surface of the side end of the material guide funnel (209) extending out of the support shell (208).
5. The organic acid tablet production equipment according to claim 1, wherein the lower punch assembly (7) comprises a lower punch (701) and a punching rod body (702) which are movably arranged in the material pressing die (6), the lower end part of the punching rod body (702) is fixed at the center of the top of the connecting disc (703), the fixing rod bodies (801) in the material discharging assembly (8) are arranged at the bottom of the connecting disc (703) in an annular array mode, the fixing rod bodies (801) downwards penetrate through the lower rotary disc (9), and a second spring (802) is arranged between the lower rotary disc (9) and the connecting disc (703) and arranged on the fixing rod bodies (801).
6. The organic acid tablet production equipment according to claim 1, wherein the pressing die (6) is arranged in the upper rotary table (5) through a first connecting key (601), and the bottom of the upper rotary table (5) is connected with the isolation sleeve (502) through a second connecting bolt (501).
7. The organic acid tablet production equipment according to claim 1, wherein the driven rotating shaft (10) is connected with the driven gear (1002) through a second connecting key (1003), the driving rotating shaft (1103) is connected with the driving gear (1101) through a third connecting key (1102), and a bearing (1001) is arranged between the driven rotating shaft (10) and the machine box body (1).
8. The organic acid tablet production equipment according to claim 1, wherein a fan (4) is arranged on the support frame (101), the output end of the fan (4) is connected with the air pipe (401), the air pipe (401) extends into the machine box body (1), a discharge pipe (103) is arranged on the side wall of the machine box body (1) and opposite to the air outlet of the air pipe (401), and a storage box body (12) for storing organic acid tablets is arranged at the lower end of the discharge pipe (103).
9. The method for producing the organic acid tablets by using the organic acid tablet production equipment as claimed in claim 1, which is characterized in that the organic acid tablet comprises the following ingredients in parts by weight: 12 parts of vitamin C; 34 parts of sodium bicarbonate; 7 parts of sodium carboxymethyl starch; 13 parts of lactose; 1.4 parts of aspartame; 1.1 parts of sweet orange essence; 1 part of micro silica gel powder; 0.5 part of magnesium stearate, adding 304 parts of polyvinylpyrrolidone-K as a binding agent into the ingredients for granulation, drying and cooling, adding 60001 parts of polyethylene glycol as a lubricating agent, uniformly mixing, and feeding into organic acid tablet production equipment for tabletting to obtain the organic acid tablets.
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| CN202010571630.XA CN111840077A (en) | 2020-06-22 | 2020-06-22 | Preparation method and production equipment of organic acid tablets |
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| CN202010571630.XA CN111840077A (en) | 2020-06-22 | 2020-06-22 | Preparation method and production equipment of organic acid tablets |
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| CN202010571630.XA Pending CN111840077A (en) | 2020-06-22 | 2020-06-22 | Preparation method and production equipment of organic acid tablets |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113398084A (en) * | 2021-07-02 | 2021-09-17 | 安徽省先锋制药有限公司 | Levetiracetam sustained release tablet and preparation method thereof |
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Application publication date: 20201030 |