CN111825524A - Preparation method and application of cyclic diol containing bridged ring structure - Google Patents
Preparation method and application of cyclic diol containing bridged ring structure Download PDFInfo
- Publication number
- CN111825524A CN111825524A CN202010710922.7A CN202010710922A CN111825524A CN 111825524 A CN111825524 A CN 111825524A CN 202010710922 A CN202010710922 A CN 202010710922A CN 111825524 A CN111825524 A CN 111825524A
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- CN
- China
- Prior art keywords
- cyclic
- ring structure
- cyclic diol
- bridged ring
- catalyst
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- -1 cyclic diol Chemical class 0.000 title claims abstract description 108
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 30
- 239000003054 catalyst Substances 0.000 claims description 74
- 238000009903 catalytic hydrogenation reaction Methods 0.000 claims description 46
- 238000007037 hydroformylation reaction Methods 0.000 claims description 42
- 238000006243 chemical reaction Methods 0.000 claims description 34
- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 claims description 32
- 238000006352 cycloaddition reaction Methods 0.000 claims description 26
- 150000001925 cycloalkenes Chemical class 0.000 claims description 25
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 22
- MGNZXYYWBUKAII-UHFFFAOYSA-N cyclohexa-1,3-diene Chemical compound C1CC=CC=C1 MGNZXYYWBUKAII-UHFFFAOYSA-N 0.000 claims description 20
- ZSWFCLXCOIISFI-UHFFFAOYSA-N cyclopentadiene Chemical group C1C=CC=C1 ZSWFCLXCOIISFI-UHFFFAOYSA-N 0.000 claims description 18
- 229910052751 metal Inorganic materials 0.000 claims description 14
- 239000002184 metal Substances 0.000 claims description 14
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 12
- HGCIXCUEYOPUTN-UHFFFAOYSA-N cis-cyclohexene Natural products C1CCC=CC1 HGCIXCUEYOPUTN-UHFFFAOYSA-N 0.000 claims description 10
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 8
- 229910052698 phosphorus Inorganic materials 0.000 claims description 8
- 239000011574 phosphorus Substances 0.000 claims description 8
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims description 5
- 229920000642 polymer Polymers 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000008569 process Effects 0.000 abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 8
- 229920000728 polyester Polymers 0.000 abstract description 7
- 239000000463 material Substances 0.000 abstract description 6
- 229920002635 polyurethane Polymers 0.000 abstract description 5
- 239000004814 polyurethane Substances 0.000 abstract description 5
- 125000002723 alicyclic group Chemical group 0.000 abstract description 4
- 150000002009 diols Chemical class 0.000 abstract description 4
- 230000002194 synthesizing effect Effects 0.000 abstract description 4
- 239000002994 raw material Substances 0.000 abstract description 3
- 238000011161 development Methods 0.000 abstract description 2
- 239000012761 high-performance material Substances 0.000 abstract description 2
- 239000000543 intermediate Substances 0.000 description 28
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 24
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 14
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 14
- 230000015572 biosynthetic process Effects 0.000 description 14
- 238000003786 synthesis reaction Methods 0.000 description 14
- 239000007789 gas Substances 0.000 description 13
- HGINCPLSRVDWNT-UHFFFAOYSA-N Acrolein Chemical compound C=CC=O HGINCPLSRVDWNT-UHFFFAOYSA-N 0.000 description 12
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 12
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 11
- 229910052739 hydrogen Inorganic materials 0.000 description 11
- 239000001257 hydrogen Substances 0.000 description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 10
- 239000002904 solvent Substances 0.000 description 10
- HVLLSGMXQDNUAL-UHFFFAOYSA-N triphenyl phosphite Chemical compound C=1C=CC=CC=1OP(OC=1C=CC=CC=1)OC1=CC=CC=C1 HVLLSGMXQDNUAL-UHFFFAOYSA-N 0.000 description 10
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 7
- STNJBCKSHOAVAJ-UHFFFAOYSA-N Methacrolein Chemical compound CC(=C)C=O STNJBCKSHOAVAJ-UHFFFAOYSA-N 0.000 description 7
- 229910052763 palladium Inorganic materials 0.000 description 7
- 229910052703 rhodium Inorganic materials 0.000 description 7
- 239000010948 rhodium Substances 0.000 description 7
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 7
- KZMGYPLQYOPHEL-UHFFFAOYSA-N Boron trifluoride etherate Chemical compound FB(F)F.CCOCC KZMGYPLQYOPHEL-UHFFFAOYSA-N 0.000 description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 6
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 6
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 description 6
- 239000007868 Raney catalyst Substances 0.000 description 5
- 229910000564 Raney nickel Inorganic materials 0.000 description 5
- 238000001914 filtration Methods 0.000 description 5
- 150000002431 hydrogen Chemical class 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 238000005160 1H NMR spectroscopy Methods 0.000 description 4
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 238000001228 spectrum Methods 0.000 description 4
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 125000003172 aldehyde group Chemical group 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 239000011968 lewis acid catalyst Substances 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 229910052759 nickel Inorganic materials 0.000 description 3
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 description 3
- 229910052697 platinum Inorganic materials 0.000 description 3
- 238000006116 polymerization reaction Methods 0.000 description 3
- 230000035484 reaction time Effects 0.000 description 3
- SVOOVMQUISJERI-UHFFFAOYSA-K rhodium(3+);triacetate Chemical compound [Rh+3].CC([O-])=O.CC([O-])=O.CC([O-])=O SVOOVMQUISJERI-UHFFFAOYSA-K 0.000 description 3
- AUHZEENZYGFFBQ-UHFFFAOYSA-N 1,3,5-trimethylbenzene Chemical compound CC1=CC(C)=CC(C)=C1 AUHZEENZYGFFBQ-UHFFFAOYSA-N 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 2
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 2
- JTPZTKBRUCILQD-UHFFFAOYSA-N 1-methylimidazolidin-2-one Chemical compound CN1CCNC1=O JTPZTKBRUCILQD-UHFFFAOYSA-N 0.000 description 2
- XESZUVZBAMCAEJ-UHFFFAOYSA-N 4-tert-butylcatechol Chemical compound CC(C)(C)C1=CC=C(O)C(O)=C1 XESZUVZBAMCAEJ-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 239000002879 Lewis base Substances 0.000 description 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 description 2
- 150000001299 aldehydes Chemical class 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 2
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 2
- PAZHOQPRMVOBDD-RMRYJAPISA-N cyclopenta-1,3-diene;(1s)-1-(2-diphenylphosphanylcyclopenta-1,4-dien-1-yl)-n,n-dimethylethanamine;iron(2+) Chemical compound [Fe+2].C=1C=C[CH-]C=1.[CH-]1C=CC(P(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1[C@@H](N(C)C)C PAZHOQPRMVOBDD-RMRYJAPISA-N 0.000 description 2
- 150000007527 lewis bases Chemical class 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
- 229910052755 nonmetal Inorganic materials 0.000 description 2
- HDKCVDHYIIKWFM-UHFFFAOYSA-K octanoate;rhodium(3+) Chemical compound [Rh+3].CCCCCCCC([O-])=O.CCCCCCCC([O-])=O.CCCCCCCC([O-])=O HDKCVDHYIIKWFM-UHFFFAOYSA-K 0.000 description 2
- NWVVVBRKAWDGAB-UHFFFAOYSA-N p-methoxyphenol Chemical compound COC1=CC=C(O)C=C1 NWVVVBRKAWDGAB-UHFFFAOYSA-N 0.000 description 2
- 150000008301 phosphite esters Chemical class 0.000 description 2
- 229910000073 phosphorus hydride Inorganic materials 0.000 description 2
- 229920000058 polyacrylate Polymers 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- YWWDBCBWQNCYNR-UHFFFAOYSA-N trimethylphosphine Chemical compound CP(C)C YWWDBCBWQNCYNR-UHFFFAOYSA-N 0.000 description 2
- CBIQXUBDNNXYJM-UHFFFAOYSA-N tris(2,2,2-trifluoroethyl) phosphite Chemical compound FC(F)(F)COP(OCC(F)(F)F)OCC(F)(F)F CBIQXUBDNNXYJM-UHFFFAOYSA-N 0.000 description 2
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 2
- MBVAQOHBPXKYMF-LNTINUHCSA-N (z)-4-hydroxypent-3-en-2-one;rhodium Chemical group [Rh].C\C(O)=C\C(C)=O.C\C(O)=C\C(C)=O.C\C(O)=C\C(C)=O MBVAQOHBPXKYMF-LNTINUHCSA-N 0.000 description 1
- MCTWTZJPVLRJOU-UHFFFAOYSA-N 1-methyl-1H-imidazole Chemical compound CN1C=CN=C1 MCTWTZJPVLRJOU-UHFFFAOYSA-N 0.000 description 1
- FDSYTWVNUJTPMA-UHFFFAOYSA-N 2-[3,9-bis(carboxymethyl)-3,6,9,15-tetrazabicyclo[9.3.1]pentadeca-1(15),11,13-trien-6-yl]acetic acid Chemical compound C1N(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC2=CC=CC1=N2 FDSYTWVNUJTPMA-UHFFFAOYSA-N 0.000 description 1
- RMGHERXMTMUMMV-UHFFFAOYSA-N 2-methoxypropane Chemical compound COC(C)C RMGHERXMTMUMMV-UHFFFAOYSA-N 0.000 description 1
- XPFCZYUVICHKDS-UHFFFAOYSA-N 3-methylbutane-1,3-diol Chemical compound CC(C)(O)CCO XPFCZYUVICHKDS-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- 239000005909 Kieselgur Substances 0.000 description 1
- 239000002841 Lewis acid Substances 0.000 description 1
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- URLKBWYHVLBVBO-UHFFFAOYSA-N Para-Xylene Chemical group CC1=CC=C(C)C=C1 URLKBWYHVLBVBO-UHFFFAOYSA-N 0.000 description 1
- 229920002396 Polyurea Polymers 0.000 description 1
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 description 1
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- YIMQCDZDWXUDCA-UHFFFAOYSA-N [4-(hydroxymethyl)cyclohexyl]methanol Chemical compound OCC1CCC(CO)CC1 YIMQCDZDWXUDCA-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000007171 acid catalysis Methods 0.000 description 1
- 239000003377 acid catalyst Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000005456 alcohol based solvent Substances 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000013064 chemical raw material Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 125000004989 dicarbonyl group Chemical group 0.000 description 1
- SBZXBUIDTXKZTM-UHFFFAOYSA-N diglyme Chemical compound COCCOCCOC SBZXBUIDTXKZTM-UHFFFAOYSA-N 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 125000006575 electron-withdrawing group Chemical group 0.000 description 1
- 239000003822 epoxy resin Substances 0.000 description 1
- 239000004210 ether based solvent Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 229910052732 germanium Inorganic materials 0.000 description 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 1
- 230000009477 glass transition Effects 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- KHBAYPJBLAOMCF-UHFFFAOYSA-N hydroxy(trimethyl)silane trifluoromethanesulfonic acid Chemical compound C[Si](C)(C)O.OS(=O)(=O)C(F)(F)F KHBAYPJBLAOMCF-UHFFFAOYSA-N 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 150000007517 lewis acids Chemical class 0.000 description 1
- YQNQTEBHHUSESQ-UHFFFAOYSA-N lithium aluminate Chemical compound [Li+].[O-][Al]=O YQNQTEBHHUSESQ-UHFFFAOYSA-N 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- IVSZLXZYQVIEFR-UHFFFAOYSA-N m-xylene Chemical group CC1=CC=CC(C)=C1 IVSZLXZYQVIEFR-UHFFFAOYSA-N 0.000 description 1
- 239000003863 metallic catalyst Substances 0.000 description 1
- 239000002808 molecular sieve Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 229920005644 polyethylene terephthalate glycol copolymer Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- VXNYVYJABGOSBX-UHFFFAOYSA-N rhodium(3+);trinitrate Chemical compound [Rh+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O VXNYVYJABGOSBX-UHFFFAOYSA-N 0.000 description 1
- SONJTKJMTWTJCT-UHFFFAOYSA-K rhodium(iii) chloride Chemical compound [Cl-].[Cl-].[Cl-].[Rh+3] SONJTKJMTWTJCT-UHFFFAOYSA-K 0.000 description 1
- 229910052707 ruthenium Inorganic materials 0.000 description 1
- 229910000077 silane Inorganic materials 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/14—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of a —CHO group
- C07C29/141—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of a —CHO group with hydrogen or hydrogen-containing gases
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/49—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with carbon monoxide
- C07C45/50—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with carbon monoxide by oxo-reactions
- C07C45/505—Asymmetric hydroformylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
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Abstract
The invention relates to a preparation method of cyclic diol, in particular to a preparation method of cyclic diol containing a bridged ring structure and application thereof. The applicant provides a preparation method of cyclic diol containing a bridged ring structure, the prepared diol contains both bridged rings and alicyclic structures, and has a good prospect of synthesizing novel high-performance materials such as novel polyester or polyurethane; in addition, the invention utilizes the mature technology in industry, the designed preparation route has the characteristics of simple and efficient process, and by using the raw materials with low price, the novel dihydric alcohol product with high yield and purity can be obtained under the mild condition, the development cost of the novel material product can be obviously reduced, and an industrialized implementation route is provided for preparing the alicyclic dihydric alcohol product.
Description
Technical Field
The invention relates to a preparation method of cyclic diol, in particular to a preparation method of cyclic diol containing a bridged ring structure and application thereof.
Background
Dihydric alcohol is an important and widely applied basic organic chemical raw material, such as ethylene glycol, propylene glycol, 1, 4-butanediol and the like which are widely applied to producing materials such as polyester fiber, polyester plastic, polyurethane and the like. The dihydric alcohol containing aliphatic cyclic structure is a special dihydroxy compound, and the unique cyclic structure can improve the heat resistance, weather resistance, hardness and other properties of the high polymer material, and has no odor and low toxicity. For example, 1, 4-Cyclohexanedimethanol (CHDM) is alicyclic diol containing a six-membered ring, is an important monomer for synthesizing various high-performance polyester materials, such as PCT, PETG, PCTA and the like, and has the characteristics of excellent thermal stability, good balance of hardness and flexibility, higher glass transition temperature and the like. Dicidol (TCD-DM) is another special alicyclic diol, can be used for synthesizing polymers such as polyacrylate, polyester, epoxy resin, polyurethane and the like, and can endow the polymers with good adhesion, high tensile strength, heat resistance, weather resistance and impact resistance.
At present, the preparation process of the cyclic diol is complex, and the yield and the purity cannot be ensured, so a new preparation method is designed to develop the novel diol, which is beneficial to developing new material products with high technical content, high added value and high performance.
Disclosure of Invention
In order to solve the above problems, the first aspect of the present invention provides a method for preparing a cyclic diol having a bridged ring structure, wherein the cyclic diol is represented by formula (1) and/or formula (2):
R1、R2respectively hydrogen atom or C1-C6 alkyl.
As a preferable technical scheme of the invention, the cyclic diol is obtained by catalytic hydrogenation of a dialdehyde intermediate, and the dialdehyde intermediate is shown as a formula (3) and/or a formula (4):
R1、R2respectively hydrogen atom or C1-C6 alkyl.
As a preferred technical scheme, in the catalytic hydrogenation, the reaction pressure is 1-10 MPa, and the reaction temperature is 80-150 ℃.
As a preferred technical solution of the present invention, the dialdehyde intermediate is obtained by hydroformylation of a monoaldehyde cyclic olefin, which is represented by formula (5) and/or formula (6):
R1、R2respectively hydrogen atom or C1-C6 alkyl.
In the hydroformylation, the monoaldehyde cycloolefins are reacted with synthesis gas under the action of a hydroformylation catalyst to obtain a dialdehyde intermediate.
As a preferable technical scheme, in the hydroformylation, the reaction pressure is 1-5 MPa, and the reaction temperature is 90-150 ℃.
In a preferred embodiment of the present invention, the hydroformylation catalyst is a combination of a metal salt and organic phosphorus.
As a preferred technical solution of the present invention, the monoaldehyde cyclic olefin is obtained by cycloaddition of a cyclic diene and a monoalkene aldehyde, wherein the cyclic diene is cyclopentadiene and/or 1, 3-cyclohexadiene, and the monoalkene aldehyde is represented by formula (7):
r is hydrogen atom or C1-C6 alkyl.
In a preferred embodiment of the present invention, the molar ratio of the cyclic diene to the monoolefin aldehyde is 1: (1-1.5).
The second aspect of the invention provides an application of the preparation method of the cyclic diol containing the bridged ring structure, which is used for preparing macromolecules.
Compared with the prior art, the invention has the following beneficial effects: the applicant provides a preparation method of cyclic diol containing a bridged ring structure, the prepared diol contains both bridged rings and alicyclic structures, and has a good prospect of synthesizing novel high-performance materials such as novel polyester or polyurethane; in addition, the invention utilizes the mature technology in industry, the designed preparation route has the characteristics of simple and efficient process, and by using the raw materials with low price, the novel dihydric alcohol product with high yield and purity can be obtained under the mild condition, the development cost of the novel material product can be obviously reduced, and an industrialized implementation route is provided for preparing the alicyclic dihydric alcohol product.
Detailed Description
The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.
The term "prepared from …" as used herein is synonymous with "comprising". The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.
The conjunction "consisting of …" excludes any unspecified elements, steps or components. If used in a claim, the phrase is intended to claim as closed, meaning that it does not contain materials other than those described, except for the conventional impurities associated therewith. When the phrase "consisting of …" appears in a clause of the subject matter of the claims rather than immediately after the subject matter, it defines only the elements described in the clause; other elements are not excluded from the claims as a whole.
When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.
The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.
Approximating language, as used herein throughout the specification and claims, is intended to modify a quantity, such that the invention is not limited to the specific quantity, but includes portions that are literally received for modification without substantial change in the basic function to which the invention is related. Accordingly, the use of "about" to modify a numerical value means that the invention is not limited to the precise value. In some instances, the approximating language may correspond to the precision of an instrument for measuring the value. In the present description and claims, range limitations may be combined and/or interchanged, including all sub-ranges contained therein if not otherwise stated.
In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.
The present invention is illustrated by the following specific embodiments, but is not limited to the specific examples given below.
The first aspect of the present invention provides a method for preparing a cyclic diol containing a bridged ring structure, wherein the cyclic diol is represented by formula (1) and/or formula (2):
R1、R2are respectively hydrogen atom or C1-C6 alkyl; further, R1、R2Respectively hydrogen atom or methyl.
In one embodiment, the cyclic diol of the present invention is obtained by catalytic hydrogenation of a dialdehyde intermediate, which is represented by formula (3) and/or formula (4):
R1、R2are respectively hydrogen atom or C1-C6 alkyl; further, R1、R2Respectively hydrogen atom or methyl.
Catalytic hydrogenation
In one embodiment, in the catalytic hydrogenation, the reaction pressure is 1-10 MPa, and the reaction temperature is 80-150 ℃; further, in the catalytic hydrogenation, the reaction pressure is 1-4 MPa, and the reaction temperature is 80-130 ℃.
Preferably, in the catalytic hydrogenation of the present invention, the catalytic hydrogenation catalyst is one of a nickel-based catalyst, a palladium-based catalyst, a platinum-based catalyst, a silver-based catalyst, a ruthenium-based catalyst, and a germanium-based catalyst. The catalytic hydrogenation catalyst is not particularly limited, and in one embodiment, the catalytic hydrogenation catalyst is one of a nickel-based catalyst, a palladium-based catalyst and a platinum-based catalyst; examples of catalytic hydrogenation catalysts include, but are not limited to, raney nickel, supported catalytic hydrogenation catalysts. The supported catalytic hydrogenation catalyst comprises a metal and a carrier, wherein the metal is selected from nickel, palladium and platinum; further, in the supported catalytic hydrogenation catalyst, the metal accounts for 3-8 wt% of the supported catalytic hydrogenation catalyst; the carrier of the present invention is not particularly limited, and may be any carrier known in the art, and examples thereof include carbon, alumina, silica gel, diatomaceous earth, zeolite molecular sieves, activated carbon, titania, lithium aluminate, and zirconia.
More preferably, the catalytic hydrogenation catalyst accounts for 4-8% of the weight of the dialdehyde intermediate.
Further preferably, in the catalytic hydrogenation of the present invention, the catalytic hydrogenation solvent is one selected from tetrahydrofuran, dichloromethane, 1, 4-dioxane, methanol, and ethanol.
Further preferably, in the catalytic hydrogenation, the dialdehyde intermediate, the catalytic hydrogenation solvent and the catalytic hydrogenation catalyst are added into a catalytic hydrogenation reaction kettle, the air in the reaction kettle is replaced by hydrogen, the reaction is carried out for 3-7 h at 80-150 ℃ and 1-10 MPa, and the cyclic diol is obtained by filtering and distilling.
In one embodiment, the dialdehyde intermediate is obtained by hydroformylation of a monoaldehyde cycloolefin, wherein the monoaldehyde cycloolefin is represented by the formula (5) and/or the formula (6):
R1、R2are respectively hydrogen atom or C1-C6 alkyl; further, R1、R2Respectively hydrogen atom or methyl.
Hydroformylation of olefins
In one embodiment, the hydroformylation process of the present invention involves reacting a monoaldehyde cycloolefin with synthesis gas over a hydroformylation catalyst to produce a dialdehyde intermediate.
In one embodiment, the syngas of the present invention comprises CO and H2Is 1: (0.5 to 2); further, in the synthesis gas of the present invention, CO and H2Is 1: 1.
preferably, the hydroformylation catalyst of the present invention is a combination of a metal catalyst and an organic phosphorus; further, the molar ratio of the metal salt catalyst to the organic phosphorus is 1: (1-20); further, the molar ratio of the metal salt catalyst to the organic phosphorus is 1: (1-10).
More preferably, the metal catalyst of the present invention is a cobalt-based catalyst or a rhodium-based catalyst; further, the metal catalyst is a rhodium catalyst; further, the rhodium catalyst is selected from one of rhodium chloride, rhodium nitrate, rhodium acetate, rhodium octanoate, rhodium acetylacetonate carbonyl and dicarbonyl acetylacetonate; furthermore, the molar concentration of the rhodium catalyst in the monoaldehyde cycloolefin is 1-100 ppm; furthermore, the molar concentration of the rhodium catalyst in the monoaldehyde cycloolefin is 40-100 ppm.
The molar concentration of the rhodium-based catalyst in the present invention is a concentration expressed in ppm in terms of parts per million of the molar amount of the monoaldehyde cycloolefin.
Further preferably, the organophosphorus disclosed by the invention is selected from one or more of trialkyl phosphine, triaryl phosphine and organic phosphite; further, the organophosphorus is organic phosphite or triaryl phosphorus; further, the organic phosphite ester is selected from one of triphenyl phosphite, trihexyl phosphite, tris (2,2, 2-trifluoroethyl) phosphite and tris (2, 4-di-tert-butyl) phosphite; further, the organic phosphite ester is selected from one of triphenyl phosphite and tris (2,2, 2-trifluoroethyl) phosphite.
Further preferably, in the hydroformylation, the reaction pressure is 1-5 MPa, and the reaction temperature is 90-150 ℃; furthermore, in the hydroformylation of the invention, the reaction pressure is 2MPa, and the reaction temperature is 110 ℃.
In a preferred embodiment, in the hydroformylation of the present invention, the hydroformylation solvent is selected from one or more of hydrocarbon solvents, ether solvents, alcohol solvents, and heterocyclic solvents. The hydroformylation solvent is not particularly limited, and examples thereof include toluene, cyclohexane, n-hexane, octane, tetrahydrofuran, methyl t-butyl ether, n-heptane, benzene, 1, 3-xylene, 1, 4-xylene, 1,3, 5-trimethylbenzene, naphthalene, methyl isopropyl ether, isoprene glycol, and 1, 4-dioxane.
In a more preferable embodiment, in the hydroformylation, the monoaldehyde cycloolefin and the hydroformylation solvent are added into a hydroformylation reaction kettle, a hydroformylation catalyst is added, the air in the reaction kettle is replaced by synthesis gas, the reaction is carried out for 2-5 h at the temperature of 80-150 ℃ under the pressure of 1-10 MPa, and the dialdehyde intermediate is obtained by reduced pressure distillation.
In one embodiment, the monoaldehyde cyclic olefin of the present invention is obtained by cycloaddition of a cyclic diene and a monoalkene aldehyde, wherein the cyclic diene is cyclopentadiene and/or 1, 3-cyclohexadiene, and the monoalkene aldehyde is represented by formula (7):
r is hydrogen atom or C1-C6 alkyl; further, R is a hydrogen atom or a methyl group.
Cycloaddition
In one embodiment, the cyclic diene and monoolefin aldehyde of the present invention are present in a molar ratio of 1: (1-1.5); further, the molar ratio of the cyclic diene to the monoolefin aldehyde according to the present invention is 1: 1.2.
preferably, in the cycloaddition, the reaction temperature is 0-100 ℃.
More preferably, in the cycloaddition, the reaction time is 2-48 h; furthermore, in the cycloaddition, the reaction time is 5-12 h.
Further preferably, in the cycloaddition of the present invention, the cycloaddition catalyst is selected from one of an enzyme catalyst, a metal catalyst and a nonmetal catalyst; further, the cycloaddition catalyst is a non-metal catalyst; further, the cycloaddition catalyst accounts for 0.1-2% of the cyclic diene by mole; further, the cycloaddition catalyst accounts for 1-2% of the cyclic diene by mole; further, the cycloaddition catalyst of the present invention is present in a molar percentage of the cyclic diene of 1.9%.
In one embodiment, the non-metallic catalyst of the present invention is selected from one of a protic acid catalyst, a protic base catalyst, a Lewis acid catalyst, and a Lewis base catalyst. As examples of Lewis acid catalysts, include, but are not limited to, boron trifluoride etherate, trifluoromethanesulfonic acid, tetrafluoroboric acid, trityltetrafluoroborate (TrBF4), tritylhexafluoroborate (TrPF6), trimethylsilanolate trifluoromethanesulfonate (TMSOTf), bis- (trifluoromethanesulfonyl) -iminosilane (TMSNTf 2); examples of Lewis base catalysts include, but are not limited to, N-methylimidazolidone, N-methylimidazole, trimethylphosphine, N-heterocyclic carbenes. In a preferred embodiment, the cycloaddition catalyst of the present invention is a Lewis acid catalyst.
Further preferably, in the cycloaddition of the present invention, the cycloaddition solvent is a solvent well known in the art, and may be, for example, dichloromethane, chloroform, tetrahydrofuran, chlorobenzene, toluene, xylene, ethyl acetate, acetone, or diethylene glycol dimethyl ether.
In a preferred embodiment, in the cycloaddition of the present invention, the polymerization inhibitor is selected from one of p-benzoquinone, p-hydroxyanisole (MEHQ), p-tert-butylcatechol (TBC), tetramethylpiperidine nitroxide radical phosphite triester; further, the polymerization inhibitor accounts for 0.1-0.5 wt% of the monoolefine aldehyde.
In a more preferred embodiment, in the cycloaddition, under the protection of nitrogen, the cyclic diene, the monoolefinic aldehyde, the polymerization inhibitor and the cycloaddition solvent are mixed, the cycloaddition catalyst is added, the mixture reacts at 0-100 ℃ for 2-48 hours, and then the temperature is reduced to room temperature, and the mixture is washed with water, desolventized and rectified under reduced pressure to obtain the monoaldehyde cycloolefin.
The applicant can obtain the cyclic diol with high yield and purity by designing a process route of the cyclic diol and starting from commonly available raw materials of cyclic diene and monoolefin aldehyde and sequentially carrying out mature cycloaddition, hydroformylation and catalytic hydrogenation reaction, and the applicant finds that by adopting a certain proportion of the cyclic diene and the monoolefin aldehyde, because double bonds in the monoolefin aldehyde are connected with acidic aldehyde groups of strong electron-withdrawing groups, the reaction activity of the cycloaddition is increased, the monoaldehyde cycloolefins with high yield and purity can be obtained at lower temperature and in time under the condition of Lewis acid catalysis, the double bonds of the monoaldehyde cycloolefins are subjected to hydroformylation reaction, and one hydrogen and one aldehyde group are respectively added on two sides of the double bonds, wherein the applicant finds that a complex is formed by adding a proper organic phosphorus and a metal catalyst, particularly selects the organic phosphorus and the metal catalyst with larger electronic and steric hindrance substituent to act together, the reaction of the monoaldehyde cycloolefins and the synthesis gas can be promoted under low catalyst concentration and reaction conditions; the applicant finds that when the reaction temperature and time are controlled to carry out catalytic hydrogenation in a hydrogen atmosphere, two aldehyde groups on the dialdehyde intermediate can be completely reduced into alcohol groups, and a diol product containing a bridged ring structure is finally obtained.
In a second aspect, the present invention provides a method for preparing a cyclic diol containing a bridged ring structure, as described above, and an application of the method for preparing a polymer.
In one embodiment, the polymer of the present invention is selected from one or more of polyacrylate, polyester, epoxy, polyurethane, polyurea.
Examples
The present invention will be specifically described below by way of examples. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.
Example 1
This example provides a method for preparing a cyclic diol having a bridged ring structure, comprising:
cycloaddition: under the protection of nitrogen, mixing cyclopentadiene, acrolein, tetramethyl piperidine nitroxide free radical phosphite triester and toluene, adding boron trifluoride diethyl etherate, reacting at 70 ℃ for 8 hours, cooling to room temperature, washing with water, desolventizing, and rectifying under reduced pressure to obtain the monoaldehyde cycloolefine; the mol ratio of the cyclopentadiene to the acrolein is 1: 1.2, the molar percentage of boron trifluoride diethyl etherate in the cyclopentadiene is 1.9 percent, and the weight percentage of the tetramethyl piperidine nitroxide radical phosphite triester in the acrolein is 0.25 percent; the monoaldehyde cycloalkene is shown below:
hydroformylation: adding the mono-aldehyde cycloolefin and the toluene into a hydroformylation reaction kettle, adding a hydroformylation catalyst, replacing air in the reaction kettle with synthesis gas, reacting for 3 hours at the temperature of 110 ℃ under the pressure of 2MPa, and distilling under reduced pressure to obtain a dialdehyde intermediate; in the synthesis gas, CO and H2Is 1: 1, the hydroformylation catalyst is a composition of dicarbonyl acetylacetone rhodium and triphenylphosphine, and the molar ratio is 1: 10, the molar concentration of the metal catalyst in the monoaldehyde cycloolefins is 93 ppm; the dialdehyde intermediate is shown as follows:
catalytic hydrogenation: adding the dialdehyde intermediate, toluene and Raney nickel into a catalytic hydrogenation reaction kettle, replacing air in the reaction kettle with hydrogen, reacting for 5h at 120 ℃ and 3MPa, filtering, and distilling to obtain the cyclic diol; the Raney nickel accounts for 6.25 percent of the weight of the dialdehyde intermediate; the cyclic diol is shown as follows:
the hydrogen spectrum of the cyclic diol is as follows: 1HNMR (CDCl3),1.02-1.08(m,2H), 1.26-1.41(m,3H), 1.92-1.98(m,2H), 2.11-2.21(m,3H), 2.96-3.11(m,1H), 3.31-3.36(m, 2H).
Example 2
This example provides a method for preparing a cyclic diol having a bridged ring structure, comprising:
cycloaddition: under the protection of nitrogen, mixing 1, 3-cyclohexadiene, methacrolein, tetramethyl piperidine nitroxide free radical phosphite triester and dichloromethane, adding trityl tetrafluoroborate, reacting at 23 ℃ for 10 ℃, cooling to room temperature, washing with water, desolventizing, and rectifying under reduced pressure to obtain the monoaldehyde cycloolefine; the molar ratio of the 1, 3-cyclohexadiene to methacrolein is 1: 1.2, the mole percentage of the trityl tetrafluoroborate to the 1, 3-cyclohexadiene is 1.9%, and the weight percentage of the tetramethyl piperidine nitroxide radical phosphite triester to the methacrolein is 0.25 wt%; the monoaldehyde cycloalkene is shown below:
hydroformylation: adding the mono-aldehyde cycloolefin and tetrahydrofuran into a hydroformylation reaction kettle, adding a hydroformylation catalyst, replacing air in the reaction kettle with synthesis gas, reacting for 3 hours at the temperature of 110 ℃ under the pressure of 2MPa, and distilling under reduced pressure to obtain a dialdehyde intermediate; in the synthesis gas, CO and H2Is 1: 1, the hydroformylation catalyst is a composition of rhodium octoate and triphenyl phosphite, and the molar ratio is 1: 5.44, the molar concentration of rhodium octanoate in monoaldehyde cycloolefin is 58.83 ppm; the dialdehyde intermediate is shown as follows:
catalytic hydrogenation: adding the dialdehyde intermediate, tetrahydrofuran and a catalytic hydrogenation catalyst into a catalytic hydrogenation reaction kettle, replacing air in the reaction kettle with hydrogen, reacting for 5 hours at 120 ℃ and 2MPa, filtering and distilling to obtain the cyclic diol; the catalytic hydrogenation catalyst is a supported catalytic hydrogenation catalyst and comprises palladium and activated carbon, wherein the palladium accounts for 5 wt% of the supported catalytic hydrogenation catalyst, and the catalytic hydrogenation catalyst accounts for 5 wt% of the dialdehyde intermediate; the cyclic diol is shown as follows:
The hydrogen spectrum of the cyclic diol is as follows: 1HNMR (CDCl3), 1.13-1.16(m,3H), 1.22-1.32(m,2H), 1.42-1.66(m,5H), 1.81-1.92(m,4H), 2.95-3.01(m,2H), 3.36-3.45(m, 2H).
Example 3
This example provides a method for preparing a cyclic diol having a bridged ring structure, comprising:
cycloaddition: under the protection of nitrogen, mixing 1, 3-cyclohexadiene, acrolein, tetramethylpiperidine nitroxide free radical phosphite triester and dichloromethane, adding trityl hexafluoroborate, reacting at 40 ℃ for 12 hours, cooling to room temperature, washing with water, desolventizing, and rectifying under reduced pressure to obtain the monoaldehyde cycloolefins; the molar ratio of the 1, 3-cyclohexadiene to the acrolein is 1: 1.2, the mole percentage of the trityl hexafluoroborate to the 1, 3-cyclohexadiene is 1.6%, and the weight percentage of the tetramethyl piperidine nitroxide radical phosphite triester to the acrolein is 0.25 wt%; the monoaldehyde cycloalkene is shown below:
hydroformylation: adding the mono-aldehyde cycloolefin and tetrahydrofuran into a hydroformylation reaction kettle, adding a hydroformylation catalyst, replacing air in the reaction kettle with synthesis gas, reacting for 3 hours at the temperature of 120 ℃ under the pressure of 2MPa, and distilling under reduced pressure to obtain a dialdehyde intermediate; in the synthesis gas, CO and H2Is 1: 1, the hydroformylation catalyst is a composition of rhodium acetate and triphenylphosphine, and the molar ratio is 1: 8, the molar concentration of rhodium acetate in the monoaldehyde cycloolefins is 85 ppm; the dialdehyde intermediate is shown as follows:
catalytic hydrogenation: adding the dialdehyde intermediate, tetrahydrofuran and raney nickel into a catalytic hydrogenation reaction kettle, replacing air in the reaction kettle with hydrogen, reacting for 5h at 120 ℃ and 3MPa, filtering, and distilling to obtain the cyclic diol; the Raney nickel accounts for 5 percent of the weight of the dialdehyde intermediate; the cyclic diol is shown as follows:
The hydrogen spectrum of the cyclic diol is as follows: 1HNMR (CDCl3), 1.16-1.32(m,2H), 1.38-1.68(m,5H), 1.83-1.88(m,3H), 2.92-3.05(m,2H), 3.32-3.45(m, 2H).
Example 4
This example provides a method for preparing a cyclic diol having a bridged ring structure, comprising:
cycloaddition: under the protection of nitrogen, mixing cyclopentadiene, methacrolein, tetramethyl piperidine nitroxyl free radical phosphite triester and toluene, adding bis- (trifluorosulfonyl) -imidosilane, reacting at 65 ℃ for 9 hours, cooling to room temperature, washing with water, desolventizing, and rectifying under reduced pressure to obtain the monoaldehyde cycloolefin; the mol ratio of the cyclopentadiene to the methacrolein is 1: 1.2, the mol percentage of the bis- (trifluorosulfonyl) -imido silane to the cyclopentadiene is 1.6 percent, and the weight percentage of the tetramethyl piperidine nitroxide radical phosphite triester to the methacrolein is 0.25 percent; the monoaldehyde cycloalkene is shown below:
hydroformylation: adding the mono-aldehyde cycloolefin and the toluene into a hydroformylation reaction kettle, adding a hydroformylation catalyst, replacing air in the reaction kettle with synthesis gas, reacting for 3 hours at the temperature of 120 ℃ under the pressure of 2MPa, and distilling under reduced pressure to obtain a dialdehyde intermediate; in the synthesis gas, CO and H2Is 1: 1, the hydroformylation catalyst is dicarbonyl ethylA composition of rhodium acetylacetonate and triphenyl phosphite in a molar ratio of 1: 6, the molar concentration of the dicarbonyl acetylacetone rhodium in the monoaldehyde cycloolefin is 67 ppm; the dialdehyde intermediate is shown as follows:
catalytic hydrogenation: adding the dialdehyde intermediate, toluene and a catalytic hydrogenation catalyst into a catalytic hydrogenation reaction kettle, replacing air in the reaction kettle with hydrogen, reacting for 5h at 120 ℃ and 2MPa, filtering and distilling to obtain the cyclic diol; the catalytic hydrogenation catalyst is a supported catalytic hydrogenation catalyst and comprises palladium and activated carbon, wherein the palladium accounts for 5 wt% of the supported catalytic hydrogenation catalyst, and the catalytic hydrogenation catalyst accounts for 5 wt% of the dialdehyde intermediate; the cyclic diol is shown as follows:
The hydrogen spectrum of the cyclic diol is as follows: 1HNMR (CDCl3),1.08-1.14(m,3H), 1.22-1.38(m,2H), 1.83-1.95(m,3H), 1.97-2.14(m,2H), 2.74-3.03(m,2H), 3.13-3.24(m,4H)
Example 5
This example provides a process for producing a cyclic diol having a bridged ring structure, which is carried out in the same manner as in example 2, except that the molar ratio of 1, 3-cyclohexadiene to methacrolein is 1: 1.8.
example 6
This example provides a process for producing a cyclic diol having a bridged ring structure, which is similar to example 2, except that trityltetrafluoroborate is replaced with N-methylimidazolidone.
Example 7
This example provides a method for preparing a cyclic diol containing a bridged ring structure, which is similar to example 2, except that triphenyl phosphite is replaced with trihexyl phosphite.
Example 8
This example provides a method for preparing a cyclic diol having a bridged ring structure, which is similar to example 2, except that the reaction temperature in the catalytic hydrogenation is 180 ℃.
Example 9
This example provides a method for preparing cyclic diol containing bridged ring structure, which is similar to example 2, except that the reaction time in the catalytic hydrogenation is 10 h.
Evaluation of Performance
The following experiments were performed as experimental groups provided in the examples.
1. Yield: the preparation of cyclic diols was carried out according to the preparation methods provided in the examples, and the yields of monoaldehyde cycloalkenes, dialdehyde intermediates and cyclic diols were calculated, and the results are shown in table 1.
2. Purity: the preparation of cyclic diols was carried out according to the preparation methods provided in the examples, and the purity of cyclic diols was tested according to gas chromatography, with the results shown in table 1.
Table 1 performance characterization test
The test results in table 1 show that the preparation method of the cyclic diol containing bridged ring structure provided by the invention has simple process, and the prepared cyclic diol has high yield and purity, and can be used for synthesis and modification of various macromolecules.
The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.
Claims (10)
2. The method for preparing the cyclic diol containing the bridged ring structure according to claim 1, wherein the cyclic diol is obtained by catalytic hydrogenation of a dialdehyde intermediate, and the dialdehyde intermediate is represented by formula (3) and/or formula (4):
R1、R2respectively hydrogen atom or C1-C6 alkyl.
3. The method for preparing cyclic diol containing a bridged ring structure according to claim 2, wherein in the catalytic hydrogenation, the reaction pressure is 1-10 MPa, and the reaction temperature is 80-150 ℃.
4. The method for preparing cyclic diol containing bridged ring structure according to claim 2, wherein the dialdehyde intermediate is obtained by hydroformylation of monoaldehyde cycloolefins, and the monoaldehyde cycloolefins are represented by formula (5) and/or formula (6):
R1、R2respectively hydrogen atom or C1-C6 alkyl.
5. The method of claim 4, wherein the hydroformylation comprises reacting a monoaldehyde cyclic olefin with syngas in the presence of a hydroformylation catalyst to obtain a dialdehyde intermediate.
6. The method for preparing cyclic diol containing bridged ring structure according to claim 4, wherein the hydroformylation is carried out under a reaction pressure of 1-5 MPa and at a reaction temperature of 90-150 ℃.
7. The method for producing a cyclic diol having a bridged ring structure according to claim 5, wherein the hydroformylation catalyst is a combination of a metal salt and an organic phosphorus.
8. The method for preparing the cyclic diol containing the bridged ring structure according to any one of claims 4 to 7, wherein the monoaldehyde cyclic olefin is obtained by cycloaddition of a cyclic diene and a monoolefin aldehyde, wherein the cyclic diene is cyclopentadiene and/or 1, 3-cyclohexadiene, and the monoolefin aldehyde is represented by the formula (7):
r is hydrogen atom or C1-C6 alkyl.
9. The method according to claim 8, wherein the molar ratio of the cyclic diene to the monoalkene aldehyde is 1: (1-1.5).
10. Use of the cyclic diol having a bridged ring structure according to any one of claims 1 to 9 for the preparation of a polymer.
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JP2011074178A (en) * | 2009-09-30 | 2011-04-14 | Sanyo Chem Ind Ltd | Polyurethane resin aqueous dispersion |
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JP2011074178A (en) * | 2009-09-30 | 2011-04-14 | Sanyo Chem Ind Ltd | Polyurethane resin aqueous dispersion |
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