CN1118237C - Sterilizing disinfectant - Google Patents
Sterilizing disinfectant Download PDFInfo
- Publication number
- CN1118237C CN1118237C CN 00131011 CN00131011A CN1118237C CN 1118237 C CN1118237 C CN 1118237C CN 00131011 CN00131011 CN 00131011 CN 00131011 A CN00131011 A CN 00131011A CN 1118237 C CN1118237 C CN 1118237C
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- Prior art keywords
- sodium perborate
- disinfectant
- sterilization
- aspirin
- present
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- Apparatus For Disinfection Or Sterilisation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a sterilizing disinfectant which is a binary packaging disinfectant of acetylsalicylic acid and sodium perborate. When the present invention is used, the acetylsalicylic acid and the sodium perborate are mixed, or the acetylsalicylic acid and the sodium perborate are separately washed down, and then, the two substances are mixed. The sterilizing disinfectant of the present invention has the advantages of favorable sterilization effect, short sterilization time, and no residue of chemical products after sterilization.
Description
The present invention relates to a kind of antibacterial disinfectant, particularly a kind of medical sterilization disinfectant.
At present, what domestic most of hospital taked employed accurate sterilization of medical instrument sterilization of making is disinfectants such as formaldehyde, ozone, glutaraldehyde, these disinfectant sterilization times are long, sterilization effect is unstable, can not sterilize fully, cause patient to infect other germ.Simultaneously, the chemical residues thing of the medicine equipment after the sterilization is difficult to clean the life safety that directly endangers patient.In addition, because disinfecting time is long, workload is big, big to medicine equipment corrosivity, many hospitals medicine equipment just is used for to follow-up patient without strict sterilization, connect two, 30 cases of use as rig heads such as the rig head of dentistry, the heads that cleans the teeth, a gastroscope uses for continuously more than ten patient, and this way has further caused the incidence of cross-infection to improve greatly.
Purpose of the present invention is exactly in order to overcome the above-mentioned shortcoming of present medical sterilization disinfectant, to provide a kind of sterilization effect good, sterilization time weak point, the medical sterilization disinfectant of the no chemical residues in sterilization back.
The present invention realizes like this.
Antibacterial disinfectant of the present invention is the two-component packaging disinfectant, and wherein the composition of antibacterial disinfectant is aspirin (acetylsalicylic acid) and sodium perborate, respectively places a packing, and wherein both weight ratios are 1: 1/10～10.Wherein the structural formula of aspirin is
The molecular formula of sodium perborate is: NaBO
23H
2OH
2O
2
Molecular weight is 153.88, and its structural formula is:
During sodium perborate of the present invention is component packaged, can also add other auxiliary material, as inorganic inhibitor, sodium phosphate (Na for example
3PO
4), sodium nitrate etc.
The structure of the two-component packaging of antibacterial disinfectant of the present invention can adopt the structure of upper and lower separation or the structure of a left side or separation, during use both is mixed row mixing again after perhaps by water two kinds of materials being washed away respectively.
Sodium perborate of the present invention certainly adopts single monohydrated sodium perborate (NaBO
3H
2O) replace.
Antibacterial disinfectant of the present invention all reaches splendid Disinfection Effect by the medical sterilization sterilizer sterilization that the soaking disinfection medicine equipment reaches 99117188.8 patent applications of inventing by the inventor, and sterilization time is short, each composition of this antibacterial disinfectant all dissolves in water, uses the no chemical residues in back.
The chemical equation of antibacterial disinfectant of the present invention is:
The invention will be further described below in conjunction with embodiment.
Embodiment 1,
(wherein inorganic inhibitor is a sodium phosphate, and consumption is 0.43 gram, by two-component packaging box packing, during use, dissolves with interior sterile distilled water with 100ml for aspirin 0.5 gram and 0.93 gram sodium perborate and inorganic inhibitor.
1, gets above-mentioned disinfectant, through the check of relevant statutory machinery, by soaking disinfection with by medical sterilization sterilizer disinfection one-period (half an hour approximately), be 100% to placing the clearance rate of dying Escherichia coli, staphylococcus aureus and withered black brood cell on the cloth sheet in the pipeline.
2, the simulated field sterile test shows: dye the haemostatic clamp that withered black brood cell is arranged, after soaking disinfection or medical sterilization sterilizer work one-period, cultivate through the meat soup pipe and not see that bacteria growing is arranged.
A, equipment
1, test strain: bacillus subtilis black variety bud cell ATCC 9372 (being called for short withered black brood cell down).And be diluted to required test and contain bacteria concentration with containing 1% peptone PBS.
2, disinfecting apparatus: the medical sterilization sterilizer of 99117188.8 patent applications.
3, medium: the meat soup pipe that contains 0.5% sodium thiosulfate+2.0% Tween 80.
4, carrier: the haemostatic clamp that blocks.
5, measuring pipette (0.1ml, 1.0ml, 5.0ml, 10.0ml), micro sample adding appliance etc.B, method
Experimentize according to 5.4.7 in Ministry of Public Health's " disinfection technology standard " third edition (1991.11) first fascicles " experimental technique standard ".The each test with three samples.Test repeats 5 times.22 ℃ of test temperatures, relative moisture 70%.C, result
Show through 5 tests: dying has withered black brood cell's haemostatic clamp, through the medical sterilization sterilizer, by after working procedure work one-period, cultivates through the meat soup pipe and not to see that bacteria growing is arranged.
Table one medical sterilization sterilizer and embodiment 1 simulated field sterile test result
The meat soup pipe is cultivated situation average control bacterium number (cfu/ spare) after experiment number work one-period
1 — — — 6.15×10
5
2 — — — 7.75×10
5
3 — — — 6.10×10
5
4 — — — 8.70×10
5
5---6.45 * 10
5Annotate: "+" expression has bacteria growing; "-" expression bacteria growing.
3, the medical sterilization sterilizer is by working procedure work one-period, is 100% for the clearance rate of the natural bacteria of dental drill surface and inner chamber.
4, the hepatitis B surface antibody failure test is:
A, detection foundation: Ministry of Health of the People's Republic of China (1999.11) " disinfection technology standard " third edition, first fascicle " experimental technique standard "
B, material:
A, Purification of HBsAg: BJ Bio-Chemical Imminization Reagent Center's product, concentration are 1mg/0.17ml, lot number 9803N.
B, microplate reader: U.S. BIO-RAD 3550 types.
C, HBsAg enzyme marking reagent box: Shanghai Shiye Kehua Biotechnology Co., Ltd, actual measurement sensitivity is 2ng/ml.
D, pollution carrier: draw HBsAg (concentration is 100ug/ml) 20ul, be applied on the cover glass carrier 40 minutes dryings of 37 ℃ of incubators.
C, method: (support methods)
There is the carrier of quantitative HBsAg a slice to put into the metal dewatering box will dying, and put into upper left, the lower-left of the sterilization carrying case of sterilizer, upper right, position, bottom right, install embodiment 1 disinfectant, energising makes this instrument in running order one-period, takes out in the metal dewatering box and dyes the carrier-pellet that HBsAg is arranged.Dying of to not sterilizing in addition has the HBsAg carrier to place under the room temperature to make positive control; Negative control is for containing 5% calf serum PBS.After test to be sterilized finishes each group carrier is put respectively and contained wash-out among the 5% calf serum PBS, press the kit determination of experimental method, calculate average OD value that each is organized,, can think that HBsAg removes when S/N＜2.1 are judged to feminine gender as a result.
D, experimental result:
Hepatitis B surface antibody failure test triplicate, the result gets its average and sees the following form:
Table two medical sterilization sterilizer and embodiment 1HBsAg failure test result
Pollute carrier disinfection experiment group positive control
Disinfection box position S/N value S/N value scope S/N value S/N value scope
Upper left 0.35 (0-0.65) 43.28 (35.88-50.66)
Lower-left 0.44 (0-0.66) 43.28 (35.88-50.66)
Upper right 0.11 (0-0.31) 43.28 (35.88-50.66)
Bottom right 0.35 (0-0.72) 43.28 (35.88-50.66)
The average OD value of negative control: 0.059
The result shows that embodiment 1 can remove the antigenicity of hepatitis B surface antibody effectively.
5, get above-mentioned Disinfectant after 54 degree insulating boxs are placed 14 days (test is valid for one year), sterilizing rate does not have decline.
Embodiment 2
Aspirin 0.5 gram and 0.5 gram sodium perborate are packed by the two-component packaging box.
Embodiment 3
Aspirin 0.1 gram and 1 gram sodium perborate are packed by the two-component packaging box.
Embodiment 4
Aspirin 1 gram and 0.1 gram sodium perborate are packed by the two-component packaging box.
Embodiment 5
Aspirin gram 0.3 and 1 gram sodium perborate is packed by the two-component packaging box.
Embodiment 6
Aspirin gram 1 gram and 0.2 gram sodium perborate are packed by the two-component packaging box.
Embodiment 7
Aspirin 1 gram and 0.2 gram sodium perborate and 1.0 gram inorganic inhibitor sodium nitrate are packed by the two-component packaging box.
Enforcement 2 to embodiment 7 of the present invention exists similar sterilization, bactericidal effect through the check demonstration to embodiment 1, the invention is not restricted to the foregoing description.
Claims (5)
1, a kind of antibacterial disinfectant is the two-component packaging disinfectant of aspirin and sodium perborate, and wherein aspirin and sodium perborate respectively place a packing, and both weight ratios are 1: 1/10～10.
2, the described antibacterial disinfectant of right claim 1 is characterized in that the structure of two-component packaging adopts the structure of upper and lower separation or the structure of left and right separation.
3, antibacterial disinfectant according to claim 1 is characterized in that sodium perborate replaces with single monohydrated sodium perborate.
4, antibacterial disinfectant according to claim 1 is characterized in that adding sodium phosphate or sodium nitrate in the sodium perborate packing.
5, according to claim 1 or 4 described antibacterial disinfectants, the composition that it is characterized in that antibacterial disinfectant is 0.5 part of aspirin and 0.5 part of sodium perborate and 0.43 part of inorganic inhibitor sodium phosphate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00131011 CN1118237C (en) | 2000-12-27 | 2000-12-27 | Sterilizing disinfectant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00131011 CN1118237C (en) | 2000-12-27 | 2000-12-27 | Sterilizing disinfectant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1305719A CN1305719A (en) | 2001-08-01 |
| CN1118237C true CN1118237C (en) | 2003-08-20 |
Family
ID=4594429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00131011 Expired - Lifetime CN1118237C (en) | 2000-12-27 | 2000-12-27 | Sterilizing disinfectant |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1118237C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102066062B (en) * | 2008-12-11 | 2013-05-08 | 北京林业大学 | Wood preservative and method for wood preservation |
| CN101803612B (en) * | 2010-04-09 | 2013-04-17 | 中国人民解放军防化指挥工程学院 | Solid binary peroxy acid disinfectant |
-
2000
- 2000-12-27 CN CN 00131011 patent/CN1118237C/en not_active Expired - Lifetime
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| Publication number | Publication date |
|---|---|
| CN1305719A (en) | 2001-08-01 |
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| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: HE DEXIAN Free format text: FORMER OWNER: HE XIAOPING Effective date: 20130626 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20130626 Address after: 4, building 309, 510000 Renmin Road, Guangzhou, Guangdong, Yuexiu District Patentee after: He Dexian Address before: 510000 Guangdong city of Guangzhou Province Yu Dong Xi Road No. 36 Cui Nga Court building 2510 room B Patentee before: He Xiaoping |
|
| CX01 | Expiry of patent term |
Granted publication date: 20030820 |
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| CX01 | Expiry of patent term |