CN111803067A - Animal magnetic resonance imaging eye protection device and using method - Google Patents
Animal magnetic resonance imaging eye protection device and using method Download PDFInfo
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- CN111803067A CN111803067A CN202010100174.0A CN202010100174A CN111803067A CN 111803067 A CN111803067 A CN 111803067A CN 202010100174 A CN202010100174 A CN 202010100174A CN 111803067 A CN111803067 A CN 111803067A
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- 238000002595 magnetic resonance imaging Methods 0.000 title claims abstract description 30
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/40—Animals
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Abstract
The invention provides an animal magnetic resonance imaging eye protection device and a using method thereof, wherein the eye protection device comprises two conical eye masks, a connecting mechanism fixed with the head of an animal is arranged on the two conical eye masks, a cotton gauze is arranged in the conical eye masks, a pressure type nozzle facing the cotton gauze is arranged at the top of each conical eye mask, the pressure type nozzle is connected with a gas transmission assembly, the gas transmission assembly comprises a first gas transmission pipe, one end of the first gas transmission pipe is connected with two second gas transmission pipes, the other end of the first gas transmission pipe is connected with a gas filling device, the second gas transmission pipe is connected with the pressure type nozzle, and a water filling port is arranged on the first gas transmission pipe. The invention can be repeatedly used while preventing the blindness of the eyes of the experimental animal, has simple operation and does not influence the omnibearing examination of the head, the body and the like of the animal.
Description
Technical Field
The invention relates to the technical field of magnetic resonance imaging instruments, in particular to an animal magnetic resonance imaging eye protection device and a using method thereof.
Background
Magnetic Resonance Imaging (MRI) has been widely used in preclinical research and medical diagnosis. Animals as a model animal for preclinical studies are widely used in imaging experimental studies. The premise of MRI imaging is that the examined part does not move macroscopically or is still, and the biggest difference between animal MRI and human MRI examination is that an animal does not cooperate with examination or experimental personnel and keeps a body position still. Therefore, in animal magnetic resonance imaging experiments, anesthetic drugs are generally injected or the animals are continuously breathed in anesthetic gas mixed with oxygen through an anesthetic device, and the animals are subjected to a series of imaging scans under deep anesthesia for a long time, namely one to two hours or even longer.
The anesthetic blocks the motor nerve fibers of skeletal muscles and diaphragm muscles, action potential cannot be transmitted downwards, nerve impulses such as receptors of cornea and effectors are blocked, and after animal anesthesia, the eyelids of eyes are not closed and are opened all the time. The magnetic resonance imaging magnet chamber is relatively dry and well ventilated, and the eyes of animals are dry for a long time, which can induce eye diseases and even blindness of the eyes. However, in order to observe the occurrence and development processes of diseases, the magnetic resonance imaging scanning needs to be repeatedly performed at different time points in the modeling process of the model animal, and if the eyes of the animal are diseased or blind, the diet, emotion and the like of the animal can be influenced, which is not favorable for the successful establishment and further long-term follow-up research of the specific disease model.
The animal should take eye-protecting measures during the magnetic resonance imaging process, but the animal is in the center of the strong magnetic field, which is not beneficial to the conventional protective measures. If wait for after an inspection is accomplished, withdraw from the scanning bed, apply the safeguard measure after, carry out next scanning again, the entering of scanning bed, go out, need relocate, not only influence the experiment process and be difficult to guarantee that the aspect position of same inspection position around the animal, direction are unanimous, are unfavorable for the image comparison of later stage.
At present, the risk of blindness of the eyes of the animal is not considered or measures are taken when the animal is subjected to a magnetic resonance imaging experiment, but the protection measures are complex and cover the whole head area, so that the head related examination is not facilitated.
Disclosure of Invention
Aiming at the problems in the animal magnetic resonance imaging experiment process and the defects in the prior art, the invention provides the animal magnetic resonance imaging eye protection device and the use method thereof, which can be repeatedly used while preventing blindness of the eyes of the experimental animal, are simple to operate and do not influence the omnibearing examination of the head, the body and the like of the animal.
The technical scheme of the invention is realized as follows: the utility model provides an animal magnetic resonance imaging eyes protector, including two conical eye patches, be provided with the coupling mechanism fixed with the animal head on two conical eye patches, be provided with cotton gauze in the conical eye patches, the top of conical eye patches is provided with the pressure type nozzle towards cotton gauze, pressure type nozzle links to each other with the gas transmission subassembly, the gas transmission subassembly includes first gas-supply pipe, the one end of first gas-supply pipe is connected with two second gas-supply pipes, the other end links to each other with the air entrainment device, the second conveyer pipe links to each other with pressure type nozzle, be provided with the water filling port on the first gas-supply pipe.
Furthermore, the water filling port is located at a position where the first gas pipe is close to the second gas pipe, a first one-way valve is arranged on the first gas pipe between the water filling port and the gas filling device and used for controlling gas to flow towards the water filling port, a second one-way valve is arranged on the first gas pipe between the water filling port and the first one-way valve and used for controlling gas and liquid to flow towards the conical eye shield.
Further, coupling mechanism includes behind the head area, first area and chin area, and the both ends in behind the head area link to each other with two conical eye-masks respectively, and the one end in first area and chin area all links to each other with a conical eye-mask, and the other end is the free end, is provided with two links on another conical eye-mask, and the free end in first area and chin area links to each other with the link respectively.
Further, the top of conical eye-shade is provided with the stock solution box, and second conveyer pipe and pressure type nozzle pass through the stock solution box and link to each other, and the tip in area behind the head links to each other with the lateral wall of stock solution box, and the one end in area before the head and chin area all links to each other with the lateral wall of a stock solution box, and two links are all fixed in on the lateral wall of another stock solution box.
Further, a sealing cover is arranged at the water injection port.
Furthermore, the back head belt, the front head belt and the chin belt are all elastic fixing belts.
Further, the distance between the cotton gauze and the opening end of the conical eye mask is 3 mm.
Further, the air-entrapping device is a hand-held air bag.
The use method of the animal magnetic resonance imaging eye protection device comprises the following steps:
(1) before the magnetic resonance scanning starts, normal saline or eyedrop is filled through a water filling port of the first gas transmission pipe and the water filling port is sealed;
(2) fixing an experimental animal on a magnetic resonance scanning bed, then respectively covering the eyes of the animal with two conical eyepatches, wherein the back head band is positioned at the back of the head of the animal, the front head band is positioned at the front of the head of the animal and is connected with one suspension loop, the chin band is positioned at the chin of the animal and is connected with the other suspension loop, and the conical eyepatches are fixed on the head of the animal;
(3) the air-entrapping device is used for inflating the first air-transporting pipe, and the physiological saline or eye drops are uniformly sprayed on the cotton gauze arranged in the conical eye shield through the pressure type nozzle under the action of air pressure, so that a moist environment is provided around the eyes of the animal.
The invention has the beneficial effects that:
the working principle of the invention is as follows: the air-entrapping device is inflated to generate pressure, the physiological saline or the eyedrop is pressurized through the first one-way valve and the second one-way valve, the physiological saline or the eyedrop is forced to be sprayed out through the pressure type nozzle by air pressure and is uniformly sprayed on the cotton gauze in the eyeshade, a moist environment is provided for the eyes of the animal, and blindness caused by dryness of the eyes in the long-time imaging and collecting process under the anesthesia state of the animal is prevented.
The invention aims to prevent blindness of the eyes of experimental animals, designs the animal magnetic resonance imaging eye protection device on the basis of not influencing the magnetic resonance experimental process, controls the spraying time and the spraying amount by inspectors to keep the eyes of the animals moist, has simple operation and low cost, does not influence the omnibearing inspection of the heads, the bodies and the like of the animals, and can be suitable for large animals such as rabbit-shaped animals, rodent animals, primates and the like.
The animal magnetic resonance imaging eye protection device is simple in structure, low in cost, convenient to use, free of entering and exiting a scanning bed and capable of being repeatedly used, sprayed liquid cannot be directly sprayed onto the eyes of an animal, motion artifacts caused by local motion of the head and the like due to stimulation of the animal are avoided, the risk of blindness of the animal in a long-term experiment process is effectively prevented, and the comprehensive MRI examination of the head, the body and the like of the animal is not influenced.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic view of a conical eyeshade;
fig. 3 is a schematic structural diagram of the liquid storage box.
Conical eye shade 1, cotton gauze 2, first back area 3, first front area 4, chin strap 5, no magnetism couple 6, link 7, pressure type nozzle 8, first gas-supply pipe 9, second gas-supply pipe 10, aerating device 11, water filling port 12, sealed lid 13, first check valve 14, second check valve 15, stock solution box 16.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without inventive effort based on the embodiments of the present invention, are within the scope of the present invention.
Example one
As shown in fig. 1-2, an animal magnetic resonance imaging eye protection device comprises two conical eyepatches 1, wherein the conical eyepatches 1 are conical hard nonmagnetic plastic structures, a layer of cotton gauze 2 is arranged in the conical eyepatches 1, the distance between the cotton gauze 2 and the opening end of the conical eyepatches 1 is 3mm, and the phenomenon that liquid is directly dripped on the eyes of animals to stimulate the eyes and cause discomfort and local movement of the eyes of the animals is avoided.
Be provided with on two conical eye patches 1 with the fixed coupling mechanism of animal head, coupling mechanism includes first back band 3, first front band 4 and chin strap 5, first back band 3, first front band 4 and chin strap 5 are elastic fixation area, the both ends of first back band 3 link to each other with two conical eye patches 1 respectively, the one end of first front band 4 and chin strap 5 all links to each other with a conical eye patch 1, the other end is the free end, and be fixed with no magnetism couple 6, be provided with two links 7 on another conical eye patch 1, the free end of first front band 4 and chin strap 5 links to each other with the link 7 that corresponds respectively. The back head belt 3 is used for connecting and fixing the two conical eyepatches 1 and is positioned at the back of the head when in use; the head belt 4 is used for fixing the conical eyeshade 1, is connected with a hanging ring 7 through a non-magnetic hook 6 around the front of the head of an animal when in use, and the chin belt 5 is used for fixing the eyeshade and is connected with the hanging ring 7 on the other side through the non-magnetic hook 6 around the chin of the animal when in use.
The pressure type nozzle 8 is installed at the top of the conical eye patch 1, the liquid outlet end of the pressure type nozzle 8 is over against the cotton gauze 2, the liquid inlet end of the pressure type nozzle 8 is connected with the gas transmission assembly, the gas transmission assembly comprises a first gas transmission pipe 9, one end of the first gas transmission pipe 9 is connected with two second gas transmission pipes 10, the other end of the first gas transmission pipe 9 is connected with the gas filling device 11, and the gas filling device 11 is a handheld air bag. The first air delivery pipe 9 and the two second air delivery pipes 10 form a Y-shaped air pipe, the second air delivery pipes are connected with the liquid inlet ends of the pressure type nozzles 8, the first air delivery pipe is provided with a water filling port 12, and the sealing cover 13 is arranged at the position of the water filling port 12.
The water filling port 12 is located the position department that first gas-supply pipe 9 is close to second gas-supply pipe 10, be provided with first check valve 14 on the first gas-supply pipe 9 between water filling port 12 and the aerating device 11, first check valve 14 is used for controlling gaseous 12 directions of flowing to the water filling port, be provided with second check valve 15 on the first gas-supply pipe 9 between water filling port 12 and the first check valve 14, second check valve 15 is used for controlling gaseous and liquid to 1 direction flow of conical eye-shade.
Example two
This embodiment is substantially the same as the first embodiment, except that: as shown in fig. 1 and 3, the top of the conical eyeshade 1 is sleeved with a liquid storage box 16, a liquid outlet of the second conveying pipe is connected with the upper end of the liquid storage box 16, a liquid inlet of the pressure type nozzle 8 is connected with the lower end of the liquid storage box 16, and the second conveying pipe is communicated with the pressure type nozzle 8 through the liquid storage box 16. The both ends of the back head belt 3 link to each other with the lateral wall that corresponds liquid storage box 16 respectively, and the one end of the preceding head belt 4 and chin strap 5 all links to each other with the lateral wall of a liquid storage box 16, and two links 7 all are fixed in on the lateral wall of another liquid storage box 16. The liquid storage box 16 is added, so that the storage capacity of the liquid medicine in the gas transmission component is improved, and meanwhile, the connection of the connecting mechanism and the eye mask is facilitated.
EXAMPLE III
The method for using the animal magnetic resonance imaging eye protection device described in the first embodiment and the second embodiment comprises the following steps:
(1) before the magnetic resonance scanning starts, normal saline or eyedrops are filled into the first air conveying pipe 9 and the second air conveying pipe 10 through the water filling port 12 of the first air conveying pipe 9, and the water filling port 12 is sealed;
(2) fixing an experimental animal on a magnetic resonance scanning bed, then respectively covering the eyes of the animal with two conical eyepatches 1, wherein a back head belt 3 is positioned at the back of the head of the animal, a front head belt 4 is positioned at the front of the head of the animal and is connected with a hanging ring 7, a chin belt 5 is positioned at the chin of the animal and is connected with another hanging ring 7, and the conical eyepatches 1 are fixed on the head of the animal;
(3) open first check valve 14 and second check valve 15, and manually press the hand-held gasbag, gas gets into first gas-supply pipe 9 through first check valve 14, normal saline or eyedrops in first gas-supply pipe 9 and the second gas-supply pipe 10 pass through the even cotton gauze 2 that sprays on conical eye shade 1 is built-in of pressure formula nozzle 8 under the gas pressure effect, provide moist environment around the animal eyes, prevent that the animal from anaesthetizing state in the long-time formation of image collection process because eyes are dry and cause the blind.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (9)
1. An animal magnetic resonance imaging eye protector which characterized in that: including two conical eye patches (1), be provided with the coupling mechanism fixed with the animal head on two conical eye patches (1), be provided with cotton gauze (2) in conical eye patches (1), the top of conical eye patches (1) is provided with pressure type nozzle (8) towards cotton gauze (2), pressure type nozzle (8) link to each other with gas transmission subassembly, gas transmission subassembly includes first gas-supply pipe (9), the one end of first gas-supply pipe (9) is connected with two second gas-supply pipes (10), the other end links to each other with aerating device (11), the second conveyer pipe links to each other with pressure type nozzle (8), be provided with water filling port (12) on first gas-supply pipe (9).
2. An animal magnetic resonance imaging eye protection device according to claim 1, wherein: the water filling port (12) is located at a position where the first air conveying pipe (9) is close to the second air conveying pipe (10), a first one-way valve (14) is arranged on the first air conveying pipe (9) between the water filling port (12) and the air entrapping device (11), the first one-way valve (14) is used for controlling air to flow towards the water filling port (12), a second one-way valve (15) is arranged on the first air conveying pipe (9) between the water filling port (12) and the first one-way valve (14), and the second one-way valve (15) is used for controlling air and liquid to flow towards the conical eye mask (1).
3. An animal magnetic resonance imaging eye protection device according to claim 1, wherein: the connecting mechanism comprises a back head belt (3), a front head belt (4) and a chin belt (5), two ends of the back head belt (3) are connected with the two conical eyepatches (1) respectively, one ends of the front head belt (4) and the chin belt (5) are connected with one conical eyepatch (1), the other end of the front head belt (4) and the chin belt (5) is a free end, two hanging rings (7) are arranged on the other conical eyepatch (1), and the free ends of the front head belt (4) and the chin belt (5) are connected with the hanging rings (7) respectively.
4. An animal magnetic resonance imaging eye protection device according to claim 3, wherein: the top of conical eye patch (1) is provided with stock solution box (16), and second conveyer pipe and pressure type nozzle (8) link to each other through stock solution box (16), and the tip of back of the head area (3) links to each other with the lateral wall of stock solution box (16), and the one end of preceding area (4) and chin strap (5) all links to each other with the lateral wall of a stock solution box (16), and two links (7) all are fixed in on the lateral wall of another stock solution box (16).
5. An animal magnetic resonance imaging eye protection device according to claim 1, wherein: a sealing cover (13) is arranged at the water injection port (12).
6. An animal magnetic resonance imaging eye protection device according to claim 3 or 4, wherein: the back head belt (3), the front head belt (4) and the chin belt (5) are all elastic fixing belts.
7. An animal magnetic resonance imaging eye protection device according to claim 1, wherein: the distance between the cotton gauze (2) and the opening end of the conical eye patch (1) is 3 mm.
8. An animal magnetic resonance imaging eye protection device according to claim 1, wherein: the air-entrapping device (11) is a hand-held air bag.
9. Use of an animal mri eye protection device according to any one of claims 1-8, comprising the steps of:
(1) before the magnetic resonance scanning starts, normal saline or eyedrop is filled through a water filling port (12) of a first air conveying pipe (9), and the water filling port (12) is sealed;
(2) fixing an experimental animal on a magnetic resonance scanning bed, then respectively covering the eyes of the animal with two conical eyepatches (1), wherein a back head belt (3) is positioned at the back of the head of the animal, a front head belt (4) is positioned at the front of the head of the animal and is connected with a hanging ring (7), a chin belt (5) is positioned at the chin of the animal and is connected with another hanging ring (7), and the conical eyepatches (1) are fixed on the head of the animal;
(3) the air-entrapping device (11) inflates the first air-transport pipe (9), and the physiological saline or the eyedrops are uniformly sprayed on the cotton gauze (2) arranged in the conical eye patch (1) through the pressure type nozzle (8) under the action of air pressure, so that a moist environment is provided around the eyes of the animal.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113100744A (en) * | 2021-03-29 | 2021-07-13 | 华中科技大学同济医学院附属协和医院 | Positioning device for animal nuclear magnetic resonance imaging |
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| JP2010063542A (en) * | 2008-09-09 | 2010-03-25 | Masaki Ariga | Instrument for curing visual fatigue |
| CN103598946A (en) * | 2013-03-14 | 2014-02-26 | 孙其刚 | Eye enlarging instrument |
| CN103462789A (en) * | 2013-09-16 | 2013-12-25 | 黄廷球 | Acupoint massage health care instrument |
| CN205163374U (en) * | 2015-11-26 | 2016-04-20 | 丹阳市职业技术教育中心 | Ware is treated to manual near -sighted intraocular pressure |
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| JP3206781U (en) * | 2016-07-14 | 2016-10-06 | 望宇 津田 | Eye pressure reduction / decompression device |
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| CN208659690U (en) * | 2017-12-18 | 2019-03-29 | 无锡市人民医院 | The eye patch with sleep improving effect of disposable Exophthalmos patient |
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