CN111777908A - Coating glue and preparation method and use method thereof - Google Patents
Coating glue and preparation method and use method thereof Download PDFInfo
- Publication number
- CN111777908A CN111777908A CN202010725565.1A CN202010725565A CN111777908A CN 111777908 A CN111777908 A CN 111777908A CN 202010725565 A CN202010725565 A CN 202010725565A CN 111777908 A CN111777908 A CN 111777908A
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- China
- Prior art keywords
- coating glue
- glue
- coating
- antioxidant
- butyl
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Classifications
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D133/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
- C09D133/04—Homopolymers or copolymers of esters
- C09D133/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
- C09D133/08—Homopolymers or copolymers of acrylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/12—Esters of monohydric alcohols or phenols
- C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
- C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
- C08F220/1804—C4-(meth)acrylate, e.g. butyl (meth)acrylate, isobutyl (meth)acrylate or tert-butyl (meth)acrylate
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D7/00—Features of coating compositions, not provided for in group C09D5/00; Processes for incorporating ingredients in coating compositions
- C09D7/40—Additives
- C09D7/48—Stabilisers against degradation by oxygen, light or heat
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Paints Or Removers (AREA)
- Adhesives Or Adhesive Processes (AREA)
Abstract
The embodiment of the invention provides coating glue and a preparation method and a using method thereof, the coating glue is prepared by methacrylic acid, methyl methacrylate, n-butyl acrylate, an ultraviolet absorbent, a hindered phenol antioxidant, an organic silicon leveling agent, an initiator and a solvent, and a coating formed on a cover glass by the coating glue can be cured quickly without glue dripping and without bubbles and glue overflow; the rapid sealing can be realized, and the time cost is saved; the observation efficiency of technicians or doctors on the microscope can be effectively improved.
Description
Technical Field
The invention relates to the technical field of glue, in particular to coating glue and a preparation method and a use method thereof.
Background
A coverslip is a thin, flat piece of glass of transparent material, typically square or rectangular, about 20 millimeters (4/5 inches) wide and a fraction of a millimeter thick, that is placed on an object under observation with a microscope. The object is typically placed between a cover glass and a slightly thicker microscope slide, which rests on a stage or slide holder of the microscope and provides physical support for the object and slide.
The main function of the coverslip is to hold the solid sample flat and the liquid sample is shaped into a flat layer of uniform thickness. The coverslip also typically serves several other functions. It holds the sample in place (either by the weight of the cover slip or, in the case of a wet mount, by surface tension) and protects the sample from dust and accidental contact. It protects the microscope objective from contact with the sample and vice versa; in oil immersion microscopes or immersion microscopes, the cover slides to prevent contact between the immersion liquid and the sample. A cover slip may be affixed to the slide to seal the sample and retard dehydration and oxidation of the sample. The microorganism and cell culture can be grown directly on the coverslip prior to placement on the slide, and the sample can be permanently mounted on the slide instead of the slide.
The common cover glass on the market is only a pure glass sheet, and the surface of the common cover glass is not coated with any layer. When using ordinary cover glass piece mounting, regardless of hand sealing still machine seals, all need to drip the sealing resin glue on the slide glass in advance, and resin glue viscosity is high, mobility is slow, produces the bubble during mounting and overflows and glue, and glue curing time is slow moreover, reads the piece for technique film-making and doctor and produces very big puzzlement.
Disclosure of Invention
In view of the above, embodiments of the present invention have been made to provide a surface coating of a cover glass and a method for preparing the same, which overcome or at least partially solve the above problems.
In order to solve the above problems, an embodiment of the present invention discloses a coating glue, including:
further, the ultraviolet absorbent is 2- (2-hydroxy-5-benzyl) benzotriazole.
Further, the hindered phenol antioxidant is an antioxidant 1076, and the chemical name of the antioxidant 1076 is octadecyl 3- (3, 5-di-tert-butyl-4-hydroxyphenyl) propionate.
Further, the organic silicon flatting agent is a water-based flatting agent BYK-333.
Further, the initiator is dibenzoyl peroxide.
Further, the solvent is a benzene-free organic solvent, wherein the benzene-free organic solvent is any one of butyl acetate or ethyl acetate.
The invention also provides a preparation method of the coating glue, which comprises the following steps:
mixing methacrylic acid, methyl methacrylate, n-butyl methacrylate and n-butyl acrylate in proportion, adding an initiator, adding a solvent with a preset temperature in an oxygen-free environment, stirring, synthesizing liquid glue with the viscosity reaching the standard by controlling the reaction temperature and time and the stirring speed, cooling, adding an ultraviolet absorbent, a hindered phenol antioxidant and an organic silicon leveling agent in proportion, stirring uniformly, standing and removing bubbles to obtain the coating glue.
The invention also provides a use method of the coating glue, which comprises the following steps:
and atomizing and spraying the coating glue on the surface of the cover glass, and naturally drying to form a coating with the thickness of 0.01MM on the surface of the cover glass.
Further, the embodiments of the present invention include the following advantages: the glue dripping is not needed, the rapid curing is realized, and no bubbles and no glue overflow are realized; the rapid sealing can be realized, and the time cost is saved; the observation efficiency of technical personnel or doctors on the microscope can be effectively improved.
Detailed Description
The present invention will be described in further detail with reference to specific embodiments in order to make the above objects, features and advantages more apparent and understandable.
The coating glue of the invention specifically comprises:
in a preferred embodiment of the present invention, the ultraviolet absorbent is 2- (2-hydroxy-5-benzyl) benzotriazole, which is a high-efficiency ultraviolet absorbent capable of effectively absorbing ultraviolet rays with the wavelength of 270-340 nm.
In a preferred embodiment of the invention, the hindered phenol antioxidant is an antioxidant 1076, the chemical name of the antioxidant 1076 is octadecyl 3- (3, 5-di-tert-butyl-4-hydroxyphenyl) propionate, and the antioxidant is a phenol antioxidant with excellent performance and can inhibit oxidative degradation and thermal degradation of many organic compounds and polymers; the ultraviolet light absorbing agent has the characteristics of good compatibility, high antioxidant efficiency, no coloring, no pollution, washing resistance, extraction resistance, heat resistance, small volatility and the like, has a synergistic effect when being used with an ultraviolet light absorbing agent, and is a product with high added value.
In a preferred embodiment of the invention, the organosilicon leveling agent is an aqueous leveling agent BYK-333, is applied to various coating systems, has excellent substrate lubricating and leveling properties, good water solubility and oil solubility, and can prevent defects such as shrinkage cavity, orange peel and the like.
In a preferred embodiment of the invention, the initiator is dibenzoyl peroxide, which is the most widely used initiator in industry.
In a preferred embodiment of the present invention, the solvent is a benzene-free organic solvent, wherein the benzene-free organic solvent is any one of butyl acetate or ethyl acetate, and is a benzene-free, low-odor, low-toxicity, environmentally-friendly organic solvent.
In a preferred embodiment of the invention, the assay is carried out by preparing in advance the laboratory instruments and reagents:
the instrument comprises the following steps: four-neck flask (250mL), electric mixer, electric heating jacket, spherical condenser tube, thermometer, nitrogen bottle, beaker, conical flask, dropper, pipette, stainless steel tank, nylon sieve, stopwatch, viscometer, film coater, thickness gauge, cover glass, slide glass, microscope.
Reagent: methyl methacrylate (MMA, c.p.), n-butyl methacrylate (BMA, c.p.), n-butyl acrylate (BA, c.p.), methacrylic acid (MAA, c.p.), dibenzoyl peroxide (BPO, c.p.), butyl acetate (NBAC, c.p.), ultraviolet absorber (C.P.), hindered phenol antioxidant (C.P.), silicone leveling agent (C.P).
TABLE 1 solvent-based thermoplastic acrylic acid Synthesis ratio
The synthesis of acrylate resins can be seen from table 1, with the following experimental steps:
(1) butyl acetate was put into a 250mL four-neck flask equipped with a stirrer, a thermometer, a condenser and a constant pressure dropping funnel, nitrogen was introduced into the flask to expel oxygen from the flask, and the flask was stirred and warmed.
(2) When the temperature is raised to 90-100 ℃, the mixed monomer dissolved with the dibenzoyl peroxide is slowly dripped, the mixed monomer is shown in the table 1, and the dripping time is about 2 hours. During the addition, the temperature was allowed to rise slightly due to the reaction exotherm, but care was taken to control the addition rate so that the temperature did not rise too quickly.
(3) After the addition, the temperature is generally between 90 and 110 ℃. Keeping the temperature for 1-2h at the temperature, then adding butyl acetate dissolved with dibenzoyl peroxide, and keeping the temperature for 30 min. Cooling while stirring, cooling to 40 deg.C, and discharging.
(4) The viscosity of the synthesized resin solution was measured (acid value and solid content were not measured at all).
TABLE 2 preparation ratio of coating glue
Firstly, use
The invention also provides a preparation method of the coating glue, which comprises the following steps:
mixing methacrylic acid, methyl methacrylate, n-butyl methacrylate and n-butyl acrylate in proportion, adding an initiator, adding a solvent with a preset temperature in a weight ratio under an oxygen-free environment, stirring, synthesizing liquid glue with the viscosity reaching the standard by controlling the reaction temperature and time and the stirring speed, cooling, adding an ultraviolet absorbent, a hindered phenol antioxidant and an organic silicon leveling agent in proportion, uniformly stirring, standing and removing bubbles to obtain the coating glue.
The invention also provides a use method of the coating glue, which comprises the following steps:
and atomizing and spraying the coating glue on the surface of the cover glass, and naturally drying to form a coating with the thickness of 0.01MM on the surface of the cover glass.
In the embodiment of the invention, coating glue is prepared according to a certain proportion, a coating with the thickness of 0.01MM is formed on the surface of a common cover glass by an atomization glue spraying method or a roller glue coating method, and the coating glue becomes a colorless transparent film after being dried; wherein, in the preferred embodiment of the invention, an atomization glue spraying method is selected; the cover glass has a uniform colorless transparent thin coating layer, and has no viscosity when dried at normal temperature. When the cover glass is pressed down, the aqueous reactant can flow rapidly and generate adhesive sealing on the surface of the coating layer instantly.
It is noted that, for simplicity of explanation, the method embodiments are described as a series of acts or combination of acts, but those skilled in the art will appreciate that the present invention is not limited by the order of acts, as some steps may occur in other orders or concurrently in accordance with the embodiments of the invention. Further, those skilled in the art will appreciate that the embodiments described in the specification are presently preferred and that no particular act is required to implement the invention.
The embodiments in the present specification are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other.
While preferred embodiments of the present invention have been described, additional variations and modifications of these embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. Therefore, it is intended that the appended claims be interpreted as including preferred embodiments and all such alterations and modifications as fall within the true scope of the embodiments of the invention.
Finally, it should also be noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or terminal that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or terminal. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or terminal apparatus that comprises the element.
The coating glue provided by the invention, the preparation method and the use method thereof are described in detail, the principle and the implementation mode of the invention are explained by applying specific examples, and the description of the examples is only used for helping to understand the method and the core idea of the invention; meanwhile, for a person skilled in the art, according to the idea of the present invention, there may be variations in the specific embodiments and the application scope, and in summary, the content of the present specification should not be construed as a limitation to the present invention.
Claims (8)
1. A coating glue, comprising:
2. the coating glue of claim 1, wherein the ultraviolet absorber is 2- (2-hydroxy-5-benzyl) benzotriazole.
3. The coating glue of claim 1, wherein the hindered phenol antioxidant is an antioxidant 1076, and the chemical name of the antioxidant 1076 is octadecyl 3- (3, 5-di-tert-butyl-4-hydroxyphenyl) propionate.
4. The coating glue of claim 1, wherein the silicone leveling agent is a water-based leveling agent BYK-333.
5. The coating glue of claim 1, wherein the initiator is dibenzoyl peroxide.
6. The coating glue of claim 1, wherein the solvent is a benzene-free organic solvent, wherein the benzene-free organic solvent is any one of butyl acetate or ethyl acetate.
7. The preparation method of the coating glue of claims 1-6, characterized by comprising: mixing methacrylic acid, methyl methacrylate, n-butyl methacrylate and n-butyl acrylate in proportion, adding an initiator, adding a solvent with a preset temperature in a weight ratio under an oxygen-free environment, stirring, synthesizing liquid glue with the viscosity reaching the standard by controlling the reaction temperature and time and the stirring speed, cooling, adding an ultraviolet absorbent, a hindered phenol antioxidant and an organic silicon leveling agent in proportion, stirring uniformly, standing and removing bubbles to obtain the coating glue.
8. The use method of the coating glue of claims 1-6, characterized by comprising: and atomizing and spraying the coating glue on the surface of the cover glass, and naturally drying to form a coating with the thickness of 0.01MM on the surface of the cover glass.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010725565.1A CN111777908A (en) | 2020-07-24 | 2020-07-24 | Coating glue and preparation method and use method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010725565.1A CN111777908A (en) | 2020-07-24 | 2020-07-24 | Coating glue and preparation method and use method thereof |
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| CN111777908A true CN111777908A (en) | 2020-10-16 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202010725565.1A Pending CN111777908A (en) | 2020-07-24 | 2020-07-24 | Coating glue and preparation method and use method thereof |
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3498860A (en) * | 1966-08-29 | 1970-03-03 | John E P Pickett | Process of mounting precoated cover glass for microscope slides |
| WO2002012857A1 (en) * | 2000-08-07 | 2002-02-14 | 3M Innovative Properties Company | Microscope cover slip materials |
| CN101346655A (en) * | 2005-10-26 | 2009-01-14 | 利·H·安格罗斯 | Microscope coverslip and uses thereof |
| CN102272224A (en) * | 2008-12-30 | 2011-12-07 | 3M创新有限公司 | Acrylic block copolymers for aerosols and aerosol adhesives |
| WO2014071959A1 (en) * | 2012-11-07 | 2014-05-15 | Morgan Adhesives Company | Cover slip materials for microscopy |
| CN106370503A (en) * | 2016-08-31 | 2017-02-01 | 宁波同盛生物科技有限公司 | Organic quick drying mounting medium |
| CN109071953A (en) * | 2016-06-17 | 2018-12-21 | 东丽株式会社 | Resin combination, cured film, the manufacturing method of cured film and display device |
| CN110462369A (en) * | 2017-02-21 | 2019-11-15 | 戴尔帕斯有限公司 | It is used to prepare the method for biological sample and the composition for sealing microscopic slide |
-
2020
- 2020-07-24 CN CN202010725565.1A patent/CN111777908A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3498860A (en) * | 1966-08-29 | 1970-03-03 | John E P Pickett | Process of mounting precoated cover glass for microscope slides |
| WO2002012857A1 (en) * | 2000-08-07 | 2002-02-14 | 3M Innovative Properties Company | Microscope cover slip materials |
| CN101346655A (en) * | 2005-10-26 | 2009-01-14 | 利·H·安格罗斯 | Microscope coverslip and uses thereof |
| CN102272224A (en) * | 2008-12-30 | 2011-12-07 | 3M创新有限公司 | Acrylic block copolymers for aerosols and aerosol adhesives |
| WO2014071959A1 (en) * | 2012-11-07 | 2014-05-15 | Morgan Adhesives Company | Cover slip materials for microscopy |
| CN109071953A (en) * | 2016-06-17 | 2018-12-21 | 东丽株式会社 | Resin combination, cured film, the manufacturing method of cured film and display device |
| CN106370503A (en) * | 2016-08-31 | 2017-02-01 | 宁波同盛生物科技有限公司 | Organic quick drying mounting medium |
| CN110462369A (en) * | 2017-02-21 | 2019-11-15 | 戴尔帕斯有限公司 | It is used to prepare the method for biological sample and the composition for sealing microscopic slide |
Non-Patent Citations (1)
| Title |
|---|
| 韩长日等: "《橡塑助剂生产工艺与技术》", 30 November 2015 * |
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