CN111773550B - Photochemical diagnosis and treatment equipment with multiple spectrum light sources - Google Patents

Photochemical diagnosis and treatment equipment with multiple spectrum light sources Download PDF

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Publication number
CN111773550B
CN111773550B CN202010662776.5A CN202010662776A CN111773550B CN 111773550 B CN111773550 B CN 111773550B CN 202010662776 A CN202010662776 A CN 202010662776A CN 111773550 B CN111773550 B CN 111773550B
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illumination
light source
ball head
led light
control module
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CN111773550A (en
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王旻舒
王薇
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Peking University Third Hospital Peking University Third Clinical Medical College
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Peking University Third Hospital Peking University Third Clinical Medical College
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Abstract

The invention provides a photochemical diagnosis and treatment device with multiple spectrum light sources, which comprises: the lamp comprises a lighting lamp holder, a lamp arm and a console; one end of the lamp arm is connected with the console, the other end of the lamp arm is provided with the illuminating lamp cap, a plurality of LED light sources with different wavelengths are arranged on the illuminating lamp cap, and the illuminating lamp cap is in signal connection with the console; the control console controls the illumination lamp head to adjust the illumination position and the illumination angle according to the operation instruction of an operator so as to provide illumination selection of different wavelengths. The invention can solve the problems that the existing photodynamic therapy equipment can not emit illumination light rays with various wavelengths simultaneously, and the light source needs to be frequently replaced, so that the working efficiency is low, can improve the working efficiency of operators, and reduces the use cost of the equipment.

Description

Photochemical diagnosis and treatment equipment with multiple spectrum light sources
Technical Field
The invention relates to the field of photoelectric medical equipment, in particular to photochemical diagnosis and treatment equipment with multiple spectral light sources.
Background
The fluorescent indicator is a substance which can emit fluorescence under the irradiation of light with specific wavelength, and is widely applied to clinical diagnosis of various diseases. The photodynamic therapy is a new technology for treating by utilizing a photosensitizer and light radiation to generate photodynamic reaction, and compared with the traditional methods such as chemotherapy, radiotherapy and the like, the photodynamic therapy has the advantages of minimally invasive, low toxicity, good selective applicability, repeatable treatment, small side effect and the like. The action principle of the photodynamic therapy is that firstly, the photosensitizer is required to be conveyed to a focus area by adopting methods such as injection, coating and the like, then the focus area is irradiated by light with specific wavelength, so that the photosensitizer generates a series of photochemical reactions, and excited singlet oxygen molecules generated by the reactions have strong oxidizability, can kill pathological cells, harmful microorganisms and the like, and further achieve the treatment purpose. The photosensitizer used in the diagnosis and treatment process of photodynamic therapy has a specific absorption wavelength, and can be effectively absorbed only by photons near the absorption wavelength. To reduce unnecessary radiation damage and save energy, the illumination light used in photodynamic therapy needs to match the absorption wavelength of the photosensitizer as closely as possible. However, the types of photosensitizers are wide, and the absorption wavelengths are also different. Most current photodynamic therapy devices have only a single wavelength light source and can only be used to excite several individual photosensitizers whose absorption wavelengths match the light source. During biomedical research and practice, it is often necessary to observe various reactions and phenomena occurring in organisms, such as microorganisms, cells, tissues, experimental animals, etc., under irradiation of light of different wavelengths. The lack of a device that can simultaneously emit illumination light of multiple wavelengths has led to extended time and increased cost for such operations.
Disclosure of Invention
The invention provides photochemical diagnosis and treatment equipment with multiple spectral light sources, which solves the problems that the conventional photodynamic treatment equipment cannot emit multiple wavelengths of illumination light simultaneously, and the light sources need to be frequently replaced, so that the working efficiency is low easily, can improve the working efficiency of operators, and reduces the use cost of the equipment.
In order to achieve the above purpose, the invention provides the following technical scheme:
a photochemical diagnosis and treatment device with multiple spectral light sources comprises: the lamp comprises a lighting lamp holder, a lamp arm and a control console;
one end of the lamp arm is connected with the console, the other end of the lamp arm is provided with the illuminating lamp cap, a plurality of LED light sources with different wavelengths are arranged on the illuminating lamp cap, and the illuminating lamp cap is in signal connection with the console;
the control console controls the illumination lamp head to adjust the illumination position and the illumination angle according to the operation instruction of an operator so as to provide illumination selection of different wavelengths.
Preferably, the lighting head comprises: the universal ball head, the light source connecting seat and the ball head base;
one end of the light source connecting seat is fixedly connected with the connecting rod of the universal ball head, the other end of the light source connecting seat is fixedly connected with the LED light source, a power supply wire slot is formed in the light source connecting seat, and each LED light source is correspondingly arranged on one universal ball head;
the universal ball head is nested in the cavity of the ball head base, and the universal ball head rotates along the cavity to adjust the illumination angle of the LED light source.
Preferably, the lighting head further comprises: adjusting the spring;
at least one adjusting spring is arranged between the bottom of the universal ball head and the bottom of the cavity of the ball head base;
the adjusting spring is used for self-locking after the universal ball head rotates, so that the universal ball head is fixed according to a set angle.
Preferably, the ball head base includes: the ball head sleeve and the ball head support;
the ball head support is provided with an installation groove, the universal ball head is arranged on the installation groove, and the ball head sleeve is fixedly connected to the ball head support and forms the cavity in the installation groove.
Preferably, the bulb support is provided with a power wire slot and is made of an elastic insulating material.
Preferably, the LED light source includes: the LED lamp comprises a base, an LED lamp bead, an outer sleeve, an inner sleeve and a lens;
the base is connected with the screw rod of the universal ball head, the LED lamp beads are arranged on the base, and one end part of the outer sleeve is vertically connected to the base;
the inner sleeve is sleeved in the other end of the outer sleeve, and the inner sleeve moves up and down along the outer sleeve by rotating the inner sleeve;
the lens is arranged at the top of the inner sleeve and used for adjusting the size of the light emitting spot of the LED lamp bead when the inner sleeve moves up and down.
Preferably, the console includes: the touch screen comprises a controller, a touch screen, a current control module, a switch control module and a position control module;
the controller performs man-machine interaction through the touch screen, and is in signal connection with the current control module, the switch control module and the position control module;
the current control module is used for controlling the current intensity of each LED lamp bead so as to adjust the illumination intensity of the LED lamp beads;
the switch control module is used for controlling the on/off of each LED lamp bead;
the position control module is used for controlling the illumination angle positions of the LED light sources with different wavelengths and/or the sliding positions of the LED light sources.
Preferably, the current control module includes: the device comprises a rectifying circuit, a multi-path branch control adjustable resistance module and an overcurrent protection module;
the rectifying circuit is used for rectifying the externally input alternating current to form direct current output;
the multi-path branch control adjustable resistance module is used for independently adjusting the resistance of the power supply circuit of each LED lamp bead so as to realize current intensity adjustment;
and the overcurrent protection module is used for carrying out overcurrent protection on each LED lamp bead.
Preferably, the controller receives an LED light source type requirement instruction, an illumination spot requirement instruction, an illumination intensity requirement instruction and/or a light source position requirement instruction through the touch screen;
the controller controls the switch control module to turn off or light the LED light sources with corresponding wavelengths according to the LED light source type requirement instruction;
the controller controls the LED light source to adjust the size of the light spot according to the illumination light spot requirement instruction;
the controller controls the current control module to adjust the illumination intensity of the LED light source according to the illumination intensity requirement instruction;
and the controller controls the position control module to adjust the illumination angle position of the LED light source according to the light source position requirement instruction.
Preferably, the controller is a microprocessor.
The invention provides photochemical diagnosis and treatment equipment with multiple spectrum light sources, which consists of a lighting lamp head, a lamp arm and a control console, wherein the lighting lamp head is provided with a plurality of LED light sources with different wavelengths, and the control console controls the lighting lamp head to adjust the lighting position and the lighting angle according to the operation instruction of an operator so as to provide lighting selection with different wavelengths. The problem of current photodynamic therapy equipment can not send multiple wavelength illumination light simultaneously, need frequently change the light source, easily lead to work efficiency low is solved, can improve operating personnel's work efficiency, reduce the use cost of equipment.
Drawings
In order to more clearly describe the specific embodiments of the present invention, the drawings to be used in the embodiments will be briefly described below.
FIG. 1 is a schematic diagram of a photochemical diagnosis and treatment apparatus with multiple spectral light sources according to the present invention;
FIG. 2 is a schematic diagram of an arrangement of LED light sources provided by the present invention;
FIG. 3 is a schematic view of an illumination head provided by the present invention;
FIG. 4 is a schematic view of an LED light source provided by the present invention;
FIG. 5 is a schematic diagram of a current control module of a console provided by the present invention;
fig. 6 is a flow chart of a medical device according to an embodiment of the present invention.
Detailed Description
In order to make the technical field of the invention better understand the scheme of the embodiment of the invention, the embodiment of the invention is further described in detail with reference to the drawings and the implementation mode.
The device aims at the problems that the conventional photodynamic therapy device only has a single-wavelength light source and lacks a device capable of simultaneously emitting illumination light rays with various wavelengths, so that the time required by work is prolonged, and the cost is increased. The invention provides photochemical diagnosis and treatment equipment with multiple spectrum light sources, which consists of a lighting lamp head, a lamp arm and a control console, wherein the lighting lamp head is provided with a plurality of LED light sources with different wavelengths, and the control console controls the lighting lamp head to adjust the lighting position and the lighting angle according to the operation instruction of an operator so as to provide lighting selection with different wavelengths. The problem of current photodynamic therapy equipment can not send multiple wavelength illumination light simultaneously, need frequently change the light source, easily lead to work efficiency low is solved, can improve operating personnel's work efficiency, reduce the use cost of equipment.
As shown in fig. 1, a photochemical diagnosis and treatment apparatus having a plurality of spectral light sources includes: a lighting head 1, a lamp arm 2 and a console 3. One end of the lamp arm 2 is connected with the console 3, the other end of the lamp arm 2 is provided with the lighting lamp holder 1, the lighting lamp holder 1 is provided with a plurality of LED light sources with different wavelengths, and the lighting lamp holder 1 is in signal connection with the console 3. The control console 3 controls the illumination lamp head to adjust the illumination position and the illumination angle according to the operation instruction of an operator so as to provide illumination selection of different wavelengths.
Specifically, the appearance of the lighting lamp holder and the lamp arm can be various types, and is similar to that of a floor type or table type common household lighting lamp, but the lamp holder can be adjusted in position and orientation angle. The shape of the lamp cap is not particularly limited, a plurality of LED light sources with different wavelengths are arranged on the front surface of the lamp cap, and the number of the light sources can be more than two without specific limitation. The arrangement of the light sources on the lamp base is not particularly limited. As shown in fig. 1, the two lamp arms 2 can rotate around the shaft, and the lower lamp arm is connected with the console by a rotatable component. Each light source of the device can independently adjust the irradiation position, the irradiation intensity and the irradiation spot size. The device is suitable for exciting various photosensitizers commonly used at present, thereby being suitable for different photodynamic therapies. The equipment can simultaneously excite a plurality of photosensitizers with different wavelengths, so that a diagnosis and treatment mode of combined application of two or more photosensitizers becomes possible. The equipment can also excite the fluorescent agent for diagnosis and the photosensitizer for treatment in sequence or simultaneously in the same diagnosis and treatment process, and synchronously apply the information obtained by diagnosis to the treatment process. In addition, the device can also provide different wavelengths of illumination and excitation light sources for biomedical experiments. The equipment can improve the working efficiency of operators and reduce the use cost of the equipment.
In one embodiment, as shown in fig. 2, the lighting head is mounted with 9 LED light sources, which are arranged as shown in fig. 2. The 9 installed LED light sources can be flexibly configured according to different application occasions of clinical diagnosis and treatment or biomedical experiments. A typical light source configuration scheme applied to clinical diagnosis and treatment comprises the following steps: LED 1: 365 nm; LED 2: 385 nm; LED 3: 400 nm; LED 4: 470 nm; LED 5: 490 nm; LED6:532 nm; LED7:640 nm; LED8:670 nm; and the LED9 is 690 nm. The emission peak wavelength of the light source corresponds to the excitation peak wavelength of various fluorescent agents and photosensitizers commonly used in clinic at present, such as riboflavin, fluorescein sodium, tiger red, hematoporphyrin, endogenous porphyrin, exogenous porphyrin, fused ring quinone, phthalocyanine, carbon quantum dots and the like, and can meet the requirements of various clinical treatments. A typical light source configuration scheme applied to biomedical experiments is as follows: LED 1: 380 nm; LED 2: 430 nm; LED 3: 480 nm; LED 4: 530 nm; LED 5: 580 nm; LED6:630 nm; LED7:680 nm; LED8:730 nm; LED9:780 nm. The emission peak wavelength of the light source covers the whole visible light band. Can meet the requirements of biological and medical experiments of visible light wave band illumination.
As shown in fig. 3, the lighting head includes: the universal ball head, the light source connecting seat and the ball head base; one end of the light source connecting seat is fixedly connected with the connecting rod of the universal ball head, the other end of the light source connecting seat is fixedly connected with the LED light source, a power supply wire slot is arranged in the light source connecting seat, and each LED light source is correspondingly arranged on one universal ball head. The universal ball head is nested in the cavity of the ball head base, and the universal ball head rotates along the cavity to adjust the illumination angle of the LED light source.
The lighting head further comprises: the spring is adjusted. At least one adjusting spring is arranged between the bottom of the universal ball head and the bottom of the cavity of the ball head base. The adjusting spring is used for self-locking after the universal ball head rotates, so that the universal ball head is fixed according to a set angle.
The bulb base includes: a ball head sleeve and a ball head support. The ball head support is provided with an installation groove, the universal ball head is arranged on the installation groove, and the ball head sleeve is fixedly connected to the ball head support and forms the cavity in the installation groove.
The ball head support is provided with a power supply wire slot and is made of elastic insulating materials.
Specifically, as shown in fig. 3, each LED light source is mounted on a universal ball, the LED light source 4 may be fixed on the light source connecting seat 12 by using a screw thread or a snap fastener, and a circuit connector is provided between the LED light source 4 and the light source connecting seat 12 to ensure power supply of the LED light source. The light source connecting seat 12 and the universal ball head 13 can be connected by means of threads, bonding and the like. The universal ball head 13 is placed in a cavity formed by the ball head sleeve 14 and the ball head support 15, the ball head sleeve 14 can be made of hard materials such as plastics or metals, and the ball head support 15 can be made of materials with certain elasticity such as rubber and resin. The head cover 14 and the head support 15 can be connected by means of threads, buckles, bonding and the like. The adjusting spring 16 is fixed on the ball head support 15 and is pressed against the bottom of the universal ball head 13. The structure can ensure that a certain pressure is slightly applied to the bottom direction of the universal ball head 13, and the universal ball head 13 can freely rotate in a solid angle within a certain range by compressing the adjusting spring 16 downwards, wherein the range of the solid angle is not less than 1 pi steradian. When the universal ball head 13 rotates to a proper angle, the pressure applied on the universal ball head 13 is eliminated, and the length of the spring 16 before compression is recovered, so that the universal ball head 13 can be tightly pressed in the ball head sleeve 14 and cannot rotate, and the self-locking effect is achieved. And through holes for arranging wires are reserved in the centers of the light source connecting seat 12, the universal ball head 13 and the ball head support 15. The ball head holder 15 is fixed on the lamp head in a manner of screw thread, snap, adhesion, etc. The structure can ensure that the irradiation direction of each light source can be adjusted in a certain space angle, and simultaneously can also ensure that each LED light source installed on the lamp holder can be independently and conveniently replaced without damage, thereby ensuring that the equipment has greater use flexibility and adaptability.
As shown in fig. 4, the LED light source includes: base 41, LED lamp pearl 42, outer sleeve 43, inner sleeve 44 and lens 45. The base 41 is connected with a screw of the universal ball head, the LED lamp beads 42 are arranged on the base 41, one end part of the outer sleeve 43 is vertically connected to the base 41, and the LED lamp beads 42 are sleeved with the end part of the outer sleeve 43. The inner sleeve 44 is sleeved in the other end of the outer sleeve 43, and the inner sleeve 44 moves up and down along the outer sleeve 43 by rotating the inner sleeve 44. The lens 45 is arranged at the top of the inner sleeve 44, and the lens 45 is used for adjusting the size of the emitting light spot of the LED lamp bead 42 when the inner sleeve 43 moves up and down.
Specifically, as shown in fig. 4, the LED lamp bead may be fixed on the base by welding, bolts, or the like. The outer sleeve can be connected with the base in a welding mode, a buckling mode and the like. The inner sleeve and the 3-outer sleeve are directly connected by self-locking threads. The lens can be fixed at the top end of the inner sleeve by adopting a buckling mode, an adhesion mode and the like. The inner sleeve can be rotated to move up and down along the outer sleeve, and the lowest position of downward movement can ensure that the upper end of the inner sleeve is higher than the upper end of the outer sleeve for convenient operation. The structure can ensure that the size of the emergent light spot of the LED light source can be adjusted within a certain range. The structure can also ensure that the lens can be quickly and conveniently replaced without damage, so that the adjustment range of the size of the illumination light spot is larger, and the equipment is more flexible to use. The lens can be a convex lens or a concave lens, and is selected according to different application occasions. The convex lens can be selected when the light needs to be converged, and the concave lens can be selected when the light needs to be diverged.
The console includes: the touch screen control device comprises a controller, a touch screen, a current control module, a switch control module and a position control module. The controller carries out human-computer interaction through the touch screen, and is in signal connection with the current control module, the switch control module and the position control module. The current control module is used for controlling the current intensity of each LED lamp bead so as to adjust the illumination intensity of the LED lamp beads. The switch control module is used for controlling the on/off of each LED lamp bead. The position control module is used for controlling the illumination angle positions of the LED light sources with different wavelengths and/or the sizes of the illumination light spots of the LED light sources.
Further, as shown in fig. 5, the current control module includes: the device comprises a rectifying circuit, a multi-path branch control adjustable resistance module and an overcurrent protection module. The rectifying circuit is used for rectifying alternating current input from the outside to form direct current output. The multipath branch control adjustable resistance module is used for independently adjusting the resistance of the power supply circuit of each LED lamp bead so as to realize current intensity adjustment. The overcurrent protection module is used for carrying out overcurrent protection on each LED lamp bead.
Specifically, after 220V alternating current power supply inputs, direct current output is formed through the rectifier module, and the branch where each LED lamp bead is located can be independently switched on and off and independently adjust the current intensity through the multi-path branch control adjustable module, so that the LED lamp bead branch can be provided with the compensation/protection module to ensure the working stability of the LED lamp beads. The circuit control can be controlled by human-computer interaction between a touch screen on the equipment and the controller.
The controller receives an LED light source type requirement instruction, an illumination light spot requirement instruction, an illumination intensity requirement instruction and/or a light source position requirement instruction through the touch screen. The controller controls the switch control module to turn off or light the LED light sources with corresponding wavelengths according to the LED light source type requirement instruction. And the controller controls the LED light source to adjust the size of the light spot according to the illumination light spot requirement instruction. And the controller controls the current control module to adjust the illumination intensity of the LED light source according to the illumination intensity requirement instruction. And the controller controls the position control module to adjust the illumination angle position of the LED light source according to the light source position requirement instruction. Further, the controller is a microprocessor.
In practical application, the flow of diagnosis and treatment by using the equipment is shown in fig. 6, and the diagnosis and treatment is started, wherein an LED light source corresponding to the excitation wavelength of the fluorescent agent is firstly turned on, the size and the position of an illumination spot of the fluorescent agent are adjusted to enable the illumination spot to irradiate the approximate focus area of a patient, the illumination intensity of the fluorescent agent is adjusted, and the fluorescent agent is excited to emit fluorescence with proper intensity; turning on an LED light source corresponding to the excitation wavelength of the photosensitizer, and adjusting the illumination of the photosensitizer to the lowest visible intensity of light spots; adjusting the size and the position of the illumination spot of the photosensitizer to ensure that the illumination spot irradiates the range indicated by fluorescence of the fluorescent agent, namely the accurate position range of the focus of the patient; turning off the phosphor illumination; adjusting the illumination intensity of the photosensitizer to meet the irradiation requirement of photosensitizer treatment and keeping irradiation for the irradiation time required by the treatment; the photosensitizer illumination is turned off. And (5) finishing diagnosis and treatment. If more than two photosensitizers are used together, light sources with different photosensitizers corresponding to excitation wavelengths can be turned on simultaneously or sequentially according to treatment requirements, and the light sources are adjusted to proper positions, sizes and intensities for treatment. If the detection is not carried out by using a fluorescent agent or the photosensitizer has a fluorescence indication effect, the photosensitizer can be directly turned on for illumination and adjusted to a proper position, size and intensity for treatment.
Similarly, a typical usage scenario of the apparatus that can perform multiple different wavelength illumination experiments on a sample in series is as follows: firstly, sequentially turning on illumination light sources required in an experiment, adjusting the spot size and the illumination angle of illumination light one by one to cover a sample to be illuminated, and adjusting the illumination light intensity one by one to meet the design requirement of the experiment; then, according to an experimental plan, turning on a light source with a first illumination wavelength in a corresponding plan, and continuously illuminating until reaching the designed illumination time and then turning off; the previous step is then repeated until the illumination experiment for all wavelengths in the experimental plan is complete.
Similarly, a typical usage flow of the apparatus for simultaneously performing different wavelength illumination experiments on a plurality of samples is as follows: firstly, sequentially turning on illumination light sources required in an experiment, adjusting the spot size and the illumination angle of illumination light one by one to enable the illumination light sources to cover samples to be illuminated respectively, and adjusting the illumination light intensity one by one to enable the illumination light intensity to meet the design requirements of the experiment; then according to the experimental plan, all illumination light sources required by the experiment are turned on, illumination is continued until the designed illumination time is reached, then the illumination is turned off, and the experiment is ended.
Example 1: the process of using the device for photodynamic therapy of port wine stains is as follows. The patient is prepared for a previous period and injected with the fluorescent indicator sodium fluorescein and the photosensitizer promoporfin in the dark at the doses used. The device illumination source is configured according to the typical clinical configuration scheme described above. Turning on a light source LED5 corresponding to fluorescein sodium excitation wavelength 490nm, adjusting the size and position of an LED5 illumination spot to just cover the erythema region of the patient, adjusting the intensity of an LED5, and exciting a fluorescent agent to emit fluorescence with proper intensity to indicate the position of a new blood vessel; turning on a light source LED6 with 532nm wavelength corresponding to the excitation wavelength of the Helporfin, adjusting an LED6 to the lowest visible intensity of the illumination light spot, and then adjusting the size and the position of the illumination light spot of an LED6 to enable the illumination light spot to just cover the range indicated by fluorescence, namely the accurate position range of the newborn blood vessel of the patient; turn off the LED 5; adjusting the illumination intensity of the LED6 to meet the irradiation requirement of photosensitizer treatment and keeping the irradiation for the irradiation time required by the treatment; the LED6 is turned off and the procedure is over.
Example 2: the procedure of the apparatus for photodynamic corneal cross-linking treatment of keratoconus is as follows. The patient is ready for the previous period, and the photosensitizer riboflavin with the use dose is infiltrated into the cornea by adopting an external application method or a soaking method in a dark room. The device illumination source is configured according to the typical clinical protocol. Turning on a light source LED1 corresponding to riboflavin excitation wavelength 365nm, adjusting the luminous intensity of an LED1 to the lowest intensity that an operator can observe an illumination spot through an ultraviolet glasses, and then adjusting the size and the position of an LED1 illumination spot to enable the illumination spot to just cover the cornea range of a patient; adjusting the illumination intensity of the LED1 to meet the irradiation requirement of photosensitizer treatment and keeping the irradiation for the irradiation time required by the treatment; the LED1 is turned off and the procedure is over.
Example 3: the experiment for observing the growth condition of the candida albicans under the irradiation of the visible light of different wave bands is carried out by using the equipment, and the process is as follows. 9 Candida albicans samples to be observed are inoculated according to the same conditions, the numbers are 1-9, the Candida albicans samples are respectively placed in a transparent incubator, and a certain interval is required to be kept between different samples during placement. The implementation equipment illumination light source is configured according to the typical biomedical experimental configuration scheme. Turning on the LED1, adjusting the size and the position of an illumination spot of the LED1 to enable the illumination spot to cover the sample 1, and adjusting the luminous intensity of the LED1 to enable the illumination brightness of the sample 1 to meet the experimental design requirements; then, the LEDs 2-9 are turned on and adjusted in sequence according to the same steps. The experimental environment was allowed to return to the dark room and maintained for 24 hours. All LED light sources were turned off and the experiment was ended.
Example 4: the experiment for observing the activity of the mouse under the irradiation of the visible light with different wave bands is carried out by using the device, and the process is as follows. The mice to be observed were placed in a transparent rearing chamber. The implementation equipment illumination light source is configured according to the typical biomedical experimental configuration scheme. An infrared camera is arranged beside the feeding box to observe and record the activity of the mouse. The LED1 is turned on, the size and the position of the illumination light spot are adjusted to cover the space in the feeding box, and the luminous intensity of the LED1 is adjusted to ensure that the illumination brightness in the feeding box meets the experimental design requirements; then, the LED1 is turned off, the LED2 is turned on, and the size and the luminous intensity of the illumination spot are adjusted according to the same steps. And by analogy, all the LED light sources are adjusted. The experimental environment was returned to the dark room state. LED1 was turned on, turned off after 24 hours of illumination, and LED2 was then turned on. By analogy, the experiment was ended after each LED was illuminated for 24 hours.
The photochemical diagnosis and treatment equipment comprises an illuminating lamp head, a lamp arm, an LED light source and a control console, wherein the illuminating lamp head is provided with the LED light sources with different wavelengths, and the control console controls the illuminating lamp head to adjust the illumination position and the illumination angle according to an operation instruction of an operator so as to provide illumination selection with different wavelengths. The problem of current photodynamic therapy equipment can not send multiple wavelength illumination light simultaneously, need frequently change the light source, easily lead to work efficiency low is solved, can improve operating personnel's work efficiency, reduce the use cost of equipment.
The construction, features and functions of the present invention have been described in detail with reference to the embodiments shown in the drawings, but the present invention is not limited to the embodiments shown in the drawings, and all equivalent embodiments modified or modified by the spirit and scope of the present invention should be protected without departing from the spirit of the present invention.

Claims (5)

1. A photochemical diagnosis and treatment device with multiple spectral light sources is characterized by comprising: the lamp comprises a lighting lamp holder, a lamp arm and a control console;
one end of the lamp arm is connected with the console, the other end of the lamp arm is provided with the lighting lamp cap, a plurality of LED light sources with different wavelengths are arranged on the lighting lamp cap, and the lighting lamp cap is in signal connection with the console;
the control console controls the illumination lamp head to adjust the illumination position and the illumination angle according to the operation instruction of an operator so as to provide illumination selection of different wavelengths;
the lighting head includes: the universal bulb comprises a universal bulb, a light source connecting seat and a bulb base; each LED light source is correspondingly installed on one universal ball head, the universal ball head is nested in a cavity of the ball head base, and the universal ball head rotates along the cavity to adjust the illumination angle of the LED light sources so as to ensure that the illumination direction of each LED light source is adjusted within a certain space angle;
one end of the light source connecting seat is fixedly connected with the connecting rod of the universal ball head, the other end of the light source connecting seat is fixedly connected with the LED light source, and a power supply wire slot is formed in the light source connecting seat;
the LED light source includes: the LED lamp comprises a base, an LED lamp bead, an outer sleeve, an inner sleeve and a lens;
the base is connected with the screw rod of the universal ball head, the LED lamp beads are arranged on the base, and one end part of the outer sleeve is vertically connected to the base;
the inner sleeve is sleeved in the other end of the outer sleeve, and the inner sleeve moves up and down along the outer sleeve by rotating the inner sleeve;
the lens is arranged at the top of the inner sleeve and used for adjusting the size of an emission light spot of the LED lamp bead when the inner sleeve moves up and down;
the lighting head further comprises: adjusting the spring;
at least one adjusting spring is arranged between the bottom of the universal ball head and the bottom of the cavity of the ball head base;
the adjusting spring is used for self-locking after the universal ball head rotates, so that the universal ball head is fixed according to a set angle;
the bulb base includes: the ball head sleeve and the ball head support;
the ball head support is provided with an installation groove, the universal ball head is arranged on the installation groove, and the ball head sleeve is fixedly connected to the ball head support and forms the cavity together with the ball head support in the installation groove;
the ball head support is provided with a power supply wire slot and is made of an elastic insulating material;
during diagnosis and treatment, the LED light source corresponding to the excitation wavelength of the fluorescent agent is turned on to adjust the size and the position of an illumination spot of the fluorescent agent so as to irradiate a focus area of a patient, adjust the illumination intensity of the fluorescent agent and excite the fluorescent agent to emit fluorescence with proper intensity; turning on the LED light source corresponding to the excitation wavelength of the photosensitizer, and adjusting the illumination of the photosensitizer to the lowest visible intensity of the light spot; adjusting the size and position of the photosensitizer illumination spot to illuminate the exact location of the patient's lesion; turning off the illumination of the fluorescent agent, adjusting the illumination intensity of the photosensitizer to meet the illumination requirement of photosensitizer treatment, and keeping illumination until the illumination time required by the treatment is met; the photosensitizer illumination is turned off.
2. The photochemical diagnosis and treatment apparatus with multiple spectral light sources of claim 1, wherein the console comprises: the touch screen control system comprises a controller, a touch screen, a current control module, a switch control module and a position control module;
the controller carries out human-computer interaction through the touch screen, and is in signal connection with the current control module, the switch control module and the position control module;
the current control module is used for controlling the current intensity of each LED lamp bead so as to adjust the illumination intensity of the LED lamp beads;
the switch control module is used for controlling the on/off of each LED lamp bead;
the position control module is used for controlling the illumination angle positions of the LED light sources with different wavelengths and/or the sliding positions of the LED light sources.
3. The photochemical diagnosis and treatment apparatus with multiple spectral light sources according to claim 2, wherein the current control module comprises: the device comprises a rectifying circuit, a multi-path branch control adjustable resistance module and an overcurrent protection module;
the rectifying circuit is used for rectifying the externally input alternating current to form direct current output;
the multi-path branch control adjustable resistance module is used for independently adjusting the resistance of the power supply circuit of each LED lamp bead so as to realize current intensity adjustment;
the overcurrent protection module is used for carrying out overcurrent protection on each LED lamp bead.
4. The photochemical diagnosis and treatment equipment with multiple spectrum light sources as claimed in claim 3, wherein the controller receives LED light source type requirement instruction, illumination spot requirement instruction, illumination intensity requirement instruction and/or light source position requirement instruction through the touch screen;
the controller controls the switch control module to turn off or light the LED light sources with corresponding wavelengths according to the LED light source type requirement instruction;
the controller controls the LED light source to adjust the size of the light spot according to the illumination light spot requirement instruction;
the controller controls the current control module to adjust the illumination intensity of the LED light source according to the illumination intensity requirement instruction;
and the controller controls the position control module to adjust the illumination angle position of the LED light source according to the light source position requirement instruction.
5. The photochemical diagnosis and treatment apparatus with multiple spectral light sources of claim 4, wherein the controller is a microprocessor.
CN202010662776.5A 2020-07-10 2020-07-10 Photochemical diagnosis and treatment equipment with multiple spectrum light sources Active CN111773550B (en)

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