CN111729195B - Waveform generation device for transcranial alternating current stimulation - Google Patents
Waveform generation device for transcranial alternating current stimulation Download PDFInfo
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- 230000000638 stimulation Effects 0.000 title claims abstract description 37
- 239000002131 composite material Substances 0.000 claims abstract description 48
- 208000024827 Alzheimer disease Diseases 0.000 claims abstract description 19
- 210000004556 brain Anatomy 0.000 claims description 19
- 238000012544 monitoring process Methods 0.000 claims description 15
- 238000010586 diagram Methods 0.000 claims description 13
- 230000002159 abnormal effect Effects 0.000 claims description 11
- 230000009471 action Effects 0.000 claims description 7
- 230000004936 stimulating effect Effects 0.000 claims description 2
- 208000010877 cognitive disease Diseases 0.000 abstract description 7
- 230000003936 working memory Effects 0.000 abstract description 6
- 208000027061 mild cognitive impairment Diseases 0.000 abstract description 5
- 210000005036 nerve Anatomy 0.000 abstract description 4
- 230000001149 cognitive effect Effects 0.000 abstract description 3
- 230000008844 regulatory mechanism Effects 0.000 abstract description 2
- 238000010168 coupling process Methods 0.000 description 6
- 230000008878 coupling Effects 0.000 description 4
- 238000005859 coupling reaction Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 230000033764 rhythmic process Effects 0.000 description 4
- 208000028698 Cognitive impairment Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
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- 206010012289 Dementia Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
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- 230000018109 developmental process Effects 0.000 description 1
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- 210000005153 frontal cortex Anatomy 0.000 description 1
- 206010027175 memory impairment Diseases 0.000 description 1
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- 238000012216 screening Methods 0.000 description 1
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- 238000006467 substitution reaction Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 210000003478 temporal lobe Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
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- H—ELECTRICITY
- H03—ELECTRONIC CIRCUITRY
- H03K—PULSE TECHNIQUE
- H03K3/00—Circuits for generating electric pulses; Monostable, bistable or multistable circuits
- H03K3/02—Generators characterised by the type of circuit or by the means used for producing pulses
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Abstract
The invention provides a waveform generation device for transcranial alternating current stimulation, which relates to the technical field of transcranial alternating current stimulation and comprises the following components: a first waveform generation circuit for generating a θ wave signal having a first waveform; a second waveform generation circuit for generating a gamma wave signal having a second waveform; and the composite circuit is used for superposing the gamma wave signal at the wave crest of the first waveform for each period of the theta wave signal to obtain a composite wave signal which is used as a stimulation signal for transcranial alternating current stimulation of the Alzheimer's disease patient. The multi-frequency-band-based multi-brain-region-stimulation multi-frequency-band-excitation multi-brain-region-stimulation multi-frequency-excitation multi-frequency-band-excitation multi-brain-region-excitation multi-frequency-band-excitation system has the advantages that a nerve regulation mechanism and an effective plastic nerve path related to working memory can be further improved, and therefore the working memory capacity and the cognitive capacity of healthy elderly, people with mild cognitive impairment and people with Alzheimer disease are improved.
Description
Technical Field
The invention relates to the technical field of transcranial alternating current stimulation, in particular to a waveform generation device for transcranial alternating current stimulation.
Background
The degree of degeneration of working memory in Alzheimer's Disease (AD) population is particularly prominent, so that the method is also an effective means for early screening of AD. Mild cognitive impairment or mild cognitive impairment (Mild Cognitive Impairment, MCI) is a state of cognitive impairment intermediate between normal aging and dementia, and can be classified into amnestic MCI (acmci) and non-amnestic MCI (naMCI) according to the cognitive domain involved, acci being specifically memory impairment-based cognitive impairment. About 10-15% of aMCI develops AD) is much higher than namCI and healthy elderly. While there is no effective treatment method for AD in progressive development, the early discovery and early intervention of aMCI in window period have important clinical practice and social significance for delaying AD transformation.
Transcranial alternating current stimulation (tcacs) is a non-invasive effective therapeutic approach to brain cognitive function regulation, however, existing tcacs stimulation modes are diverse, and can be broadly divided into two main types according to the stimulation application brain region and the choice of the effective rhythms of the stimulation: (1) Single frequency or cross frequency stimulation of a single brain region, such as applying single θ (frequency: 4-7 hz) rhythms or θ and γ waves (frequency: 25-100 hz) cross frequency stimulation to the forehead cortex; (2) A single band phase-coupled stimulus to the multiple brain regions, such as a phase-synchronized stimulus that applies the θ rhythm to the frontal cortex and temporal lobes. Both of these tACS stimulation patterns proved to promote the θ and γ rhythms PAC (phase-amplitude coupling), helping healthy elderly, MCI or AD people to promote working memory. However, there is no stimulation mode of a composite waveform of theta wave and gamma wave.
Disclosure of Invention
Aiming at the problems existing in the prior art, the invention provides a waveform generation device for transcranial alternating current stimulation, which specifically comprises:
a first waveform generation circuit for generating a θ wave signal having a first waveform;
a second waveform generation circuit for generating a gamma wave signal having a second waveform;
and the compound circuit is respectively connected with the output end of the first waveform generation circuit and the output end of the second waveform generation circuit and is used for superposing the gamma wave signal at the crest of the first waveform for each period of the theta wave signal to obtain a compound wave signal which is used as a stimulation signal for stimulating the transcranial alternating current of the Alzheimer's disease patient.
Preferably, the device further comprises a plurality of output electrodes, each output electrode is connected with the output end of the composite circuit through a distribution circuit, the composite wave signals output by the composite circuit are distributed to each output electrode after frequency modulation and amplitude modulation are carried out by the distribution circuit, and the composite wave signals respectively act on different brain areas of the Alzheimer disease patient through each output electrode.
Preferably, the frequency and amplitude modulated composite wave signals have different phases and amplitudes.
Preferably, each output electrode includes an electrode output safety control circuit and an output electrode interface, an input end of the electrode output safety control circuit is connected with an output end of the distribution circuit, and an output end of the electrode output safety control circuit is connected with the output electrode interface;
the electrode output safety control circuit is used for carrying out state monitoring on the composite wave signals after frequency modulation and amplitude modulation, outputting the composite wave signals through the output electrode interface when the state monitoring result is normal so as to act on different brain areas of the Alzheimer disease patient, and cutting off signal output to the output motor interface when the state monitoring result is abnormal.
Preferably, the circuit further comprises a filter, wherein the input end of the filter is connected with the output end of the composite circuit, the output end of the filter is connected with the input end of the distribution circuit, and the composite wave signal is filtered by the filter and then is sent into the distribution circuit.
Preferably, the display device further comprises a comprehensive oscillography display which is respectively connected with the first waveform generation circuit, the second waveform generation circuit, the filter and the output end of each output electrode;
the comprehensive oscillography display is used for displaying the waveform diagram of the theta wave signal, the waveform diagram of the gamma wave signal, the waveform diagram of the composite wave signal and the waveform diagram of the signals which are input to the output electrodes after frequency modulation and amplitude modulation respectively.
Preferably, the portable electronic device further comprises a safe power supply which is respectively connected with the first waveform generation circuit and the second waveform generation circuit and is used for respectively supplying power to the first waveform generation circuit and the second waveform generation circuit.
Preferably, the safety power supply further comprises a safety breaker, the safety power supply is connected with the first waveform generation circuit and the second waveform generation circuit through the safety breaker respectively, and the safety breaker is used for conducting safety breaking action when detecting that the real-time voltage and/or the real-time current of the safety power supply are abnormal.
Preferably, the amplitude of the second waveform is smaller than the amplitude of the first waveform.
Preferably, the first waveform has a wavelength of [25 hz, 100 hz ], and the second waveform has a wavelength of [4 hz, 7 hz ].
The technical scheme has the following advantages or beneficial effects:
1) The complex wave signals are formed through multi-frequency-band coupling, and the stimulation mode of multi-brain area stimulation is carried out through a plurality of output electrodes, so that a nerve regulation mechanism and an effective plastic nerve path related to working memory can be further improved, and the working memory capacity and the cognitive capacity of healthy elderly people, people with mild cognitive impairment and people with Alzheimer's disease can be improved;
2) The two paths of waveforms are adopted, and an independent waveform generating circuit is adopted, so that independent adjustment of waveform parameters is facilitated, and an adjusting circuit of a composite wave signal is simplified.
Drawings
FIG. 1 is a schematic circuit diagram of a waveform generation device for transcranial AC stimulation in accordance with a preferred embodiment of the present invention;
FIG. 2 is a schematic diagram showing waveforms of the θ wave signal according to the preferred embodiment of the present invention;
FIG. 3 is a schematic diagram showing waveforms of gamma wave signals according to a preferred embodiment of the present invention;
fig. 4 is a waveform diagram of a complex signal according to a preferred embodiment of the present invention.
Detailed Description
The invention will now be described in detail with reference to the drawings and specific examples. The present invention is not limited to the embodiment, and other embodiments may fall within the scope of the present invention as long as they conform to the gist of the present invention.
In accordance with the above-mentioned problems of the prior art, the present invention provides a waveform generating apparatus for transcranial ac stimulation, as shown in fig. 1 to 4, which specifically comprises:
a first waveform generation circuit 1 for generating a θ wave signal having a first waveform;
a second waveform generation circuit 2 for generating a gamma wave signal having a second waveform;
the composite circuit 3 is respectively connected with the output end of the first waveform generation circuit 1 and the output end of the second waveform generation circuit 2, and is used for superposing gamma wave signals at the wave crest of the first waveform for each period of theta wave signals to obtain composite wave signals which are used as stimulation signals for transcranial alternating current stimulation of patients with Alzheimer's disease.
Specifically, in this embodiment, the present invention forms a composite wave signal as a stimulation waveform for transcranial ac stimulation by a multi-band coupling method, where the multi-band coupling method is designed to superimpose and couple a first waveform corresponding to a θ wave signal and a second waveform corresponding to a γ wave signal.
Further specifically, a composite circuit is adopted to perform superposition modulation on the two paths of waveforms to form a superposition coupling waveform, and the superposition coupling waveform is the waveform of the composite wave signal. As shown in fig. 2, the first waveform corresponding to the θ -wave signal is shown in fig. 3 as the second waveform corresponding to the γ -wave signal, and for each period of the θ -wave signal, the second waveform corresponding to the γ -wave signal is superimposed at the upper peak and trough of the first waveform corresponding to the θ -wave signal, and the second waveform corresponding to the γ -wave signal is not superimposed at the lower peak and trough of the first waveform corresponding to the θ -wave signal, and the period is cycled to form the waveform of the composite wave signal shown in fig. 4. Preferably, the amplitude of the second waveform corresponding to the superimposed gamma wave signal is smaller than the amplitude of the first waveform corresponding to the Yubo signal, and the relative amplitude difference is adjustable. The wavelength of the first waveform corresponding to the θ -wave signal is preferably 25 hz to 100 hz, the wavelength of the second waveform corresponding to the γ -wave signal is preferably 4 hz to 7 hz, and the phase can be adjusted slightly according to the use condition. More preferably, the first waveform and the second waveform respectively adopt independent waveform generating circuits, so that waveform parameters of the first waveform and the second waveform can be conveniently and independently adjusted, and an adjusting circuit for synthesizing the composite wave signal is relatively simple.
In the preferred embodiment of the invention, the brain-strengthening device further comprises a plurality of output electrodes, each output electrode is connected with the output end of the composite circuit 3 through a distribution circuit 4, and the composite wave signal output by the composite circuit 3 is distributed to each output electrode after being subjected to frequency modulation and amplitude modulation through the distribution circuit 4 and respectively acts on different brain areas of the Alzheimer disease patient through each output electrode.
Specifically, in this embodiment, by providing a plurality of output electrodes, a plurality of complex signals can be simultaneously output to simultaneously act on the multiple brain regions to perform simultaneous stimulation, the complex signals output by each output electrode having different phases and amplitudes.
In a preferred embodiment of the present invention, the frequency and amplitude modulated composite wave signals have different phases and amplitudes.
In the preferred embodiment of the invention, the output electrode comprises an electrode output safety control circuit 5 and an output electrode interface 6, wherein the input end of the electrode output safety control circuit 5 is connected with the output end of the distribution circuit 4, and the output end of the electrode output safety control circuit 5 is connected with the output electrode interface 6;
the electrode output safety control circuit is used for carrying out state monitoring on the frequency and amplitude modulated composite wave signals, outputting the composite wave signals through the output electrode interface when the state monitoring result is normal so as to act on different brain areas of the Alzheimer disease patient, and cutting off the signal output to the output motor interface when the state monitoring result is abnormal.
Specifically, in this embodiment, the above state monitoring includes, but is not limited to, monitoring the amplitude, the frequency and the waveform of the composite wave signal, and since the amplitude, the frequency or the waveform is abnormal and may cause injury to the human body, by monitoring the state of the composite wave waveform, the state monitoring result is indicated to be abnormal when the amplitude exceeds the preset amplitude threshold, the state monitoring result is indicated to be abnormal when the frequency exceeds the preset frequency threshold, and the state monitoring result is indicated to be abnormal when the waveform is fluctuating to be abnormal, at this time, the signal output to the output motor interface is cut off, so as to effectively avoid injury to the human body.
In the preferred embodiment of the present invention, the present invention further comprises a filter 7, wherein an input end of the filter 7 is connected to an output end of the composite circuit 3, an output end of the filter 7 is connected to an input end of the distribution circuit 4, and the composite wave signal is filtered by the filter 7 and then is sent to the distribution circuit 4.
In the preferred embodiment of the present invention, the display device further comprises a comprehensive oscillometric display 8, which is respectively connected to the first waveform generating circuit 1, the second waveform generating circuit 2, the filter 7 and the output end of each output electrode;
the integrated oscillometric display 8 is used for displaying the waveform of the theta wave signal, the waveform of the gamma wave signal, the waveform of the composite wave signal and the waveform of the signals which are input to the output electrodes after frequency modulation and amplitude modulation.
In the preferred embodiment of the present invention, a safe power supply 9 is further included and connected to the first waveform generation circuit 1 and the second waveform generation circuit 2, respectively, for supplying power to the first waveform generation circuit 1 and the second waveform generation circuit 2, respectively.
In a preferred embodiment of the present invention, the present invention further comprises a safety breaker 10, and the safety power supply 9 is connected to the first waveform generation circuit 1 and the second waveform generation circuit 2 through the safety breaker 10, wherein the safety breaker 10 is used for performing a safety breaking action when detecting that the real-time voltage and/or the real-time current of the safety power supply are abnormal.
Specifically, in this embodiment, the safety shut-off device 10 alarms as a safety shut-off action when detecting that the real-time voltage of the safety power supply exceeds 3% of the preset voltage threshold, and performs the power-off process as a safety shut-off action when the real-time voltage exceeds 5% of the voltage threshold, or the safety shut-off device alarms as a safety shut-off action when detecting that the real-time current of the safety power supply exceeds 3% of the preset current threshold, and performs the power-off process as a safety shut-off action when the real-time current exceeds 5% of the current threshold, so as to protect the subsequent circuit.
Specifically, as shown in fig. 1, the schematic circuit diagram of the waveform generation device of the present invention is that the supply voltage of the safety power supply 9 is preferably 5V, the output of the safety power supply 9 is stabilized and constant, and then is supplied to the first waveform generation circuit 1 and the second waveform generation circuit 2 via the shielding cable respectively, so as to generate the first brain wave waveform representing the θ brain wave and the second brain wave waveform representing the γ brain wave respectively, the two waveforms enter the composite circuit 3 via the shielding wire to generate the composite brain wave waveform, one path of the composite brain wave waveform is sampled and transmitted to the composite oscillography display 8 for display, and meanwhile, the composite brain wave waveform is transmitted to the filter 7 for filtering and then is transmitted to the distribution circuit 4 for frequency modulation and amplitude modulation and then is distributed to each output electrode, and meanwhile, the frequency modulation and amplitude modulation composite brain wave waveform sample output by each output electrode is displayed on the composite oscillography display 8 for a doctor or a researcher to check.
In a preferred embodiment of the present invention, the amplitude of the second waveform is smaller than the amplitude of the first waveform.
In a preferred embodiment of the invention, the first waveform has a wavelength of [25 Hz, 100 Hz ], and the second waveform has a wavelength of [4 Hz, 7 Hz ].
The foregoing description is only illustrative of the preferred embodiments of the present invention and is not to be construed as limiting the scope of the invention, and it will be appreciated by those skilled in the art that equivalent substitutions and obvious variations may be made using the description and drawings, and are intended to be included within the scope of the present invention.
Claims (9)
1. A transcranial alternating current stimulation waveform generation device, comprising:
a first waveform generation circuit for generating a θ wave signal having a first waveform;
a second waveform generation circuit for generating a gamma wave signal having a second waveform;
the composite circuit is respectively connected with the output end of the first waveform generation circuit and the output end of the second waveform generation circuit and is used for superposing the gamma wave signal at the crest of the first waveform for each period of the theta wave signal to obtain a composite wave signal which is used as a stimulation signal for stimulating the transcranial alternating current of the Alzheimer's disease patient;
the composite wave signal output by the composite circuit is subjected to frequency modulation and amplitude modulation by the distribution circuit and then distributed to the output electrodes, and the output electrodes respectively act on different brain areas of the Alzheimer disease patient.
2. The transcranial alternating current stimulation waveform generation device according to claim 1, wherein each of the complex signals after frequency modulation and amplitude modulation has a different phase and amplitude.
3. The transcranial alternating current stimulation waveform generation device according to claim 1, wherein each output electrode comprises an electrode output safety control circuit and an output electrode interface, wherein an input end of the electrode output safety control circuit is connected with an output end of the distribution circuit, and an output end of the electrode output safety control circuit is connected with the output electrode interface;
the electrode output safety control circuit is used for carrying out state monitoring on the composite wave signals after frequency modulation and amplitude modulation, outputting the composite wave signals through the output electrode interface when the state monitoring result is normal so as to act on different brain areas of the Alzheimer disease patient, and cutting off signal output to the output motor interface when the state monitoring result is abnormal.
4. The transcranial alternating current stimulation waveform generation device according to claim 1, further comprising a filter, wherein an input end of the filter is connected to an output end of the composite circuit, an output end of the filter is connected to an input end of the distribution circuit, and the composite wave signal is filtered by the filter and then sent to the distribution circuit.
5. The transcranial alternating current stimulation waveform generation device of claim 4, further comprising a comprehensive oscillometric display connected to the first waveform generation circuit, the second waveform generation circuit, the filter, and the output of each of the output electrodes, respectively;
the comprehensive oscillography display is used for displaying the waveform diagram of the theta wave signal, the waveform diagram of the gamma wave signal, the waveform diagram of the composite wave signal and the waveform diagram of the signals which are input to the output electrodes after frequency modulation and amplitude modulation respectively.
6. The transcranial alternating current stimulation waveform generation device of claim 1, further comprising a safety power supply connected to the first waveform generation circuit and the second waveform generation circuit, respectively, for powering the first waveform generation circuit and the second waveform generation circuit, respectively.
7. The transcranial alternating current stimulation waveform generation device according to claim 6, further comprising a safety breaker, wherein the safety power supply is connected to the first waveform generation circuit and the second waveform generation circuit through the safety breaker, respectively, and the safety breaker is used for performing a safety breaking action when detecting that the real-time voltage and/or the real-time current of the safety power supply is abnormal.
8. The transcranial alternating current stimulation waveform generation device of claim 1, wherein an amplitude of the second waveform is less than an amplitude of the first waveform.
9. The transcranial alternating current stimulation waveform generation device of claim 1, wherein the first waveform has a wavelength of [25 hz, 100 hz ] and the second waveform has a wavelength of [4 hz, 7 hz ].
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| CN108939292A (en) * | 2018-07-23 | 2018-12-07 | 中国人民解放军第四军医大学 | A kind of biological tissue's time domain interference electrical stimulation device and its application method |
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| EP2819745B1 (en) * | 2012-02-29 | 2018-10-10 | The Cleveland Clinic Foundation | System and method for generating composite patterns of stimulation or waveforms |
| US20150283382A1 (en) * | 2014-04-04 | 2015-10-08 | Med-El Elektromedizinische Geraete Gmbh | Respiration Sensors For Recording Of Triggered Respiratory Signals In Neurostimulators |
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| CN104307101A (en) * | 2014-10-13 | 2015-01-28 | 中国人民解放军第三军医大学第三附属医院 | Method and device for generating simulated current for driving gastrointestinal pace-making system |
| CN108939292A (en) * | 2018-07-23 | 2018-12-07 | 中国人民解放军第四军医大学 | A kind of biological tissue's time domain interference electrical stimulation device and its application method |
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| Zhang jingling等."Phase average waveform and phase difference analysis of different leads for Alzheimer's disease electroencephalograph signals".《Journal of medical imaging and health informatics》.2018,全文. * |
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