CN111729130A - Artificial lens coating with excellent biological anti-fouling performance and preparation method thereof - Google Patents
Artificial lens coating with excellent biological anti-fouling performance and preparation method thereof Download PDFInfo
- Publication number
- CN111729130A CN111729130A CN202010782786.2A CN202010782786A CN111729130A CN 111729130 A CN111729130 A CN 111729130A CN 202010782786 A CN202010782786 A CN 202010782786A CN 111729130 A CN111729130 A CN 111729130A
- Authority
- CN
- China
- Prior art keywords
- coating
- intraocular lens
- preparing
- biological anti
- artificial lens
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
The invention discloses a preparation method of an artificial lens coating with excellent biological anti-fouling performance, which comprises the following steps: carrying out low-temperature plasma surface treatment on the surface of the intraocular lens material, then coating an adhesive on the surface of the intraocular lens material, and drying to obtain a transition layer; and preparing a functional layer coating solution with the concentration of 0.1-30 wt% by using a hydrophilic polymer, then coating the functional layer coating solution on the transition layer, and drying to obtain the artificial lens coating with excellent biological anti-fouling performance. The invention also provides the artificial lens coating with excellent biological anti-fouling performance, which is prepared by the method. The invention adjusts the surface characteristic of the artificial lens by combining the transition layer and the functional layer, improves the hydrophilicity and the biological anti-pollution property of the material surface, improves the biocompatibility of the artificial lens, and effectively prevents or reduces the adhesion of cells, proteins, bacteria and the like on the surface of the lens and the occurrence of inflammatory reaction and other problems, thereby reducing the probability of secondary cataract.
Description
Technical Field
The invention belongs to the technical field of medical implant materials for ophthalmology, and particularly relates to an artificial lens coating with excellent biological anti-fouling performance and a preparation method thereof.
Background
The world health organization reports that cataract is the first global blinding eye disease and is caused by the opacification of the crystalline lens, and the light cannot penetrate the opacification crystalline lens and fall on the retina, so that the vision is reduced. The clinical treatment is mainly carried out by means of operation. The cataract treatment is from ancient India gold needle cataract extraction, extracapsular cataract extraction, intracapsular cataract extraction, and further to the existing ultrasonic emulsification cataract operation and femtosecond laser cataract operation, and the like, which proves that the operation is the only scientific method for treating the cataract. The current more advanced cataract surgery modes mainly comprise ultrasonic emulsification cataract surgery, femtosecond laser cataract surgery and the like. During the surgical procedure, the original opacified lens needs to be aspirated and a new intraocular lens is simultaneously implanted. However, artificial lenses such as polymethyl methacrylate (PMMA), polyhydroxyethyl methacrylate hydrogel (PHEMA), and silicone rubber, which are widely used at present, are different from lenses in physiological states, and thus foreign body reactions generally occur after implantation into human eyes, resulting in various postoperative complications, and then secondary opacification of the lenses. Therefore, a method for improving the biocompatibility of the artificial lens under the premise of not changing the shape, hardness, transparency and other bulk properties of the artificial lens is always searched.
The biocompatibility of an intraocular lens is generally divided into uveal compatibility and capsular membrane compatibility, wherein the former is related to the damage of a blood-aqueous humor barrier and the foreign body reaction of the uveal membrane to the lens, and mainly shows inflammatory foreign body reactions at the early stage and the late stage after operation; the latter is associated with the residual Lens Epithelial Cells (LECs) and capsular sac response to the lens, and is mainly manifested by anterior/posterior capsular opacification (ACO/PCO), capsular bag shrinkage, etc. caused by LECs proliferation, migration, differentiation. Therefore, effective control of the surface properties of intraocular lenses by various methods of surface modification is a major approach to improve their biocompatibility. The adhesion of cells, proteins, bacteria and the like can be effectively reduced by changing the hydrophilic and hydrophobic properties of the surface of the lens material. However, the actual operation of the modification process in the prior art has certain technical difficulty, and the PEG drug-loaded coating is mainly fixed on the surface of the crystalline lens in a plasma grafting reaction mode, so that the thickness and the drug-loaded amount of the drug-loaded coating are limited, and the efficacy time is limited; therefore, the coating which is more convenient and effective to operate and has better biological anti-fouling effect and is suitable for the artificial lens and the preparation method thereof have very important clinical significance.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides the artificial lens coating with excellent biological anti-pollution performance and the preparation method thereof, the surface characteristics of the artificial lens are adjusted by combining the transition layer and the functional layer, the hydrophilicity and the biological anti-pollution performance of the material surface are improved, the biocompatibility of the artificial lens is improved, the adhesion of cells, proteins, bacteria and the like on the lens surface and the occurrence of inflammatory reaction and other problems are effectively prevented or reduced, and thus the probability of secondary cataract is reduced.
In order to achieve the purpose, the technical scheme adopted by the invention for solving the technical problems is as follows: the preparation method of the artificial lens coating with excellent biological anti-fouling performance is provided, and comprises the following steps:
(1) carrying out low-temperature plasma surface treatment on the surface of the intraocular lens material, then coating an adhesive on the surface of the intraocular lens material, and drying to obtain a transition layer;
(2) and (2) preparing a functional layer coating solution with the concentration of 0.1-30 wt% by using a hydrophilic polymer, then coating the functional layer coating solution on the transition layer obtained in the step (1), and drying to obtain the artificial lens coating with excellent biological anti-fouling performance.
Further, in the step (1), the voltage is 50-150V and the time is 1-90 s during the low-temperature plasma surface treatment.
Further, the artificial lens material is hard polymethyl methacrylate, soft silicon rubber, silicon gel, polyhydroxyethyl methacrylate or hydrophobic acrylate.
Furthermore, the adhesive is at least one of epoxy resin, animal bone glue, protein glue and acrylate structural glue.
Further, the hydrophilic polymer is at least one of polyethylene glycol, polyoxyethylene, poly-2-methacryloyloxyethyl phosphorylcholine, polyvinylpyrrolidone, polyacrylic acid, polyvinyl alcohol, hyaluronic acid, collagen, heparin, and hirudin.
Furthermore, the weight average molecular weight Mw of the polyethylene glycol is less than or equal to 2 × 104g/mol, polyoxyethylene weight average molecular weight Mw is more than or equal to 2 × 104g/mol。
Further, the solvent of the functional layer coating solution is at least one of water, methanol, ethanol, acetone, chloroform and dichloromethane.
Further, in the steps (1) to (2), the coating mode is dip coating, spin coating, drip coating, spray coating or brush coating.
Further, in the steps (1) to (2), the coating time is 5s to 30min, and the drying temperature is 30 to 80 ℃.
Further, in the steps (1) to (2), the drying mode is drying or nitrogen blow drying.
The artificial lens coating with excellent biological anti-fouling performance is prepared by the preparation method of the artificial lens coating with excellent biological anti-fouling performance.
Furthermore, the contact angle of the surface of the artificial lens coating with excellent biological anti-fouling performance is 0-80 degrees.
In summary, the invention has the following advantages:
1. the invention adjusts the surface characteristic of the artificial lens by combining the transition layer and the functional layer, improves the hydrophilicity and the biological anti-pollution property of the material surface, improves the biocompatibility of the artificial lens, and effectively prevents or reduces the adhesion of cells, proteins, bacteria and the like on the surface of the lens and the occurrence of inflammatory reaction and other problems, thereby reducing the probability of secondary cataract.
2. The bonding force between the intraocular lens body material and the surface functional layer is improved in a transition layer bonding mode, the problem that the surface polarity of the intraocular lens body material is rapidly declined along with the prolonging of time after the intraocular lens body material is simply subjected to plasma treatment, so that the coating is easy to fall off is solved, and the action time of the anti-fouling coating is effectively prolonged. The method is simple, convenient and mild, has low cost, is suitable for various intraocular lens materials, is easy to realize industrialized large-area treatment, and is very convenient for the modified materials in the aspects of disinfection, packaging, transportation and the like. The coating adopts a physical coating mode, the transition layer and the functional layer are very thin, the transparent characteristic of the material can be well kept, and the requirement of implanting the material as an intraocular lens in the later period is not influenced.
3. The functional layer and the transition layer are selected in various ways, various combinations and collocation can be carried out according to different requirements of the biological anti-fouling characteristics in the specific using process, the limitation of a coating method and the types of polymers is avoided, and the method can be further widened to the preparation and application of anti-fouling coatings in other fields.
4. The coating has good hydrophilic and anti-fouling characteristics, can effectively prevent adhesion and proliferation of proteins, cells and bacteria, has good biocompatibility, and is expected to greatly reduce or avoid inflammatory foreign body reaction after the intraocular lens is implanted.
Drawings
FIG. 1 is a graphical representation of the results of transparency tests of different IOL coating modifying materials;
FIG. 2 is a fluorescent photograph of an intraocular lens material after and after surface treatment and cultured with mouse fibroblasts (L929) for 1 day;
FIG. 3 is a laser confocal contrast image of protein adsorption experiments before and after surface treatment of an intraocular lens material;
FIG. 4 is a photograph showing the comparison of agar diffusion toxicity test before and after the surface treatment of the artificial lens material.
Detailed Description
Example 1
A preparation method of an artificial lens coating with excellent biological anti-fouling performance comprises the following steps:
(1) carrying out low-temperature plasma surface treatment on the hard polymethyl methacrylate artificial lens material for 40s under the voltage of 50V, then putting the hard polymethyl methacrylate artificial lens material into an epoxy resin solution for dip-coating for 15s, and drying at the temperature of 50 ℃ to obtain a transition layer;
(2) preparing a polyvinyl alcohol solution with the concentration of 5mg/ml, then placing the transition layer obtained in the step (1) into the polyvinyl alcohol solution, immersing for 5min, and drying at the temperature of 50 ℃ to obtain the artificial lens coating with excellent biological anti-fouling performance.
Example 2
A preparation method of an artificial lens coating with excellent biological anti-fouling performance comprises the following steps:
(1) performing low-temperature plasma surface treatment on the rigid polymethyl methacrylate artificial lens material for 30s at a voltage of 70V, then putting the rigid polymethyl methacrylate artificial lens material into an epoxy resin solution for dip coating for 20s, and drying at a temperature of 50 ℃ to obtain a transition layer;
(2) preparing a polyoxyethylene solution with the concentration of 10mg/ml, then putting the transition layer obtained in the step (1) into the polyoxyethylene solution, immersing for 5min, and drying at the temperature of 50 ℃ to obtain the artificial lens coating with excellent biological anti-fouling performance.
Example 3
A preparation method of an artificial lens coating with excellent biological anti-fouling performance comprises the following steps:
(1) carrying out low-temperature plasma surface treatment on the polyhydroxyethyl methacrylate intraocular lens material for 90s under the voltage of 80V, then putting the polyhydroxyethyl methacrylate intraocular lens material into an epoxy resin solution for dip-coating for 10s, and drying at the temperature of 60 ℃ to obtain a transition layer;
(2) preparing a poly 2-methacryloyloxyethyl phosphorylcholine solution with the concentration of 8mg/ml, then putting the transition layer obtained in the step (1) into the poly 2-methacryloyloxyethyl phosphorylcholine solution to immerse for 15s, and drying at the temperature of 30 ℃ to obtain the artificial lens coating with excellent biological anti-fouling performance.
Example 4
A preparation method of an artificial lens coating with excellent biological anti-fouling performance comprises the following steps:
(1) performing low-temperature plasma surface treatment on the polyhydroxyethyl methacrylate intraocular lens material for 15s under the voltage of 90V, then spin-coating an epoxy resin solution on the surface of the polyhydroxyethyl methacrylate intraocular lens material, and drying by blowing nitrogen to obtain a transition layer;
(2) preparing a hyaluronic acid solution with the concentration of 2mg/ml, then placing the transition layer obtained in the step (1) into the hyaluronic acid solution to be immersed for 20s, and drying at the temperature of 50 ℃ to obtain the artificial lens coating with excellent biological anti-fouling performance.
Example 5
A preparation method of an artificial lens coating with excellent biological anti-fouling performance comprises the following steps:
(1) carrying out low-temperature plasma surface treatment on the transparent silicone rubber intraocular lens material for 45s at a voltage of 100V, then dripping an animal bone glue solution on the surface of the transparent silicone rubber intraocular lens material, and drying by nitrogen to obtain a transition layer;
(2) preparing a poly 2-methacryloyloxyethyl phosphorylcholine solution with the concentration of 6mg/ml, then putting the transition layer obtained in the step (1) into the poly 2-methacryloyloxyethyl phosphorylcholine solution to immerse for 20min, and drying at the temperature of 40 ℃ to obtain the intraocular lens coating with excellent biological anti-fouling performance.
Example 6
A preparation method of an artificial lens coating with excellent biological anti-fouling performance comprises the following steps:
(1) performing low-temperature plasma surface treatment on the transparent silicone rubber intraocular lens material for 20s at a voltage of 110V, then spraying an acrylate structural adhesive solution on the surface of the transparent silicone rubber intraocular lens material, and drying at a temperature of 40 ℃ to obtain a transition layer;
(2) preparing a heparin solution with the concentration of 4mg/ml, then placing the transition layer obtained in the step (1) into the heparin solution to be immersed for 10min, and drying at the temperature of 30 ℃ to obtain the artificial lens coating with excellent biological anti-fouling performance.
Example 7
A preparation method of an artificial lens coating with excellent biological anti-fouling performance comprises the following steps:
(1) performing low-temperature plasma surface treatment on the transparent silica gel intraocular lens material for 10s at a voltage of 120V, then spraying a protein gel solution on the surface of the transparent silica gel intraocular lens material, and drying at a temperature of 40 ℃ to obtain a transition layer;
(2) preparing a heparin solution with the concentration of 2mg/ml, spin-coating the heparin solution on the transition layer obtained in the step (1), and drying at the temperature of 30 ℃ to obtain the artificial lens coating with excellent biological anti-pollution performance.
Example 8
A preparation method of an artificial lens coating with excellent biological anti-fouling performance comprises the following steps:
(1) carrying out low-temperature plasma surface treatment on the transparent hydrophobic acrylate intraocular lens material for 10s at a voltage of 130V, then putting the transparent hydrophobic acrylate intraocular lens material into an epoxy resin solution for dip-coating for 20s, and drying at a temperature of 50 ℃ to obtain a transition layer;
(2) preparing a polyvinyl alcohol solution with the concentration of 6mg/ml, then placing the transition layer obtained in the step (1) into the polyvinyl alcohol solution, immersing for 15min, and drying at the temperature of 50 ℃ to obtain the artificial lens coating with excellent biological anti-fouling performance.
Example 9
(1) Carrying out low-temperature plasma surface treatment on the transparent hydrophobic acrylate intraocular lens material for 20s at the voltage of 150V, then putting the transparent hydrophobic acrylate intraocular lens material into an epoxy resin solution for dip-coating for 20s, and drying at the temperature of 50 ℃ to obtain a transition layer;
(2) preparing a polyethylene glycol solution with the concentration of 10mg/ml, then placing the transition layer obtained in the step (1) into the polyethylene glycol solution to be immersed for 5min, and drying at the temperature of 30 ℃ to obtain the artificial lens coating with excellent biological anti-fouling performance.
Example 10
(1) Performing low-temperature plasma surface treatment on the transparent silicon rubber intraocular lens material for 20s under the voltage of 90V, then spin-coating an epoxy resin solution on the surface of the transparent silicon rubber intraocular lens material, and blow-drying with nitrogen to obtain a transition layer;
(2) preparing a poly 2-methacryloyloxyethyl phosphorylcholine solution with the concentration of 5mg/ml, then putting the transition layer obtained in the step (1) into the poly 2-methacryloyloxyethyl phosphorylcholine solution to immerse for 8min, and drying at the temperature of 30 ℃ to obtain the intraocular lens coating with excellent biological anti-fouling performance.
The intraocular lens coatings with excellent antifouling performance obtained in the examples were subjected to a transparency test (fig. 1), a mouse fibroblast (L929) test (fig. 2), a protein adsorption test (fig. 3), and an agar diffusion toxicity test (fig. 4), respectively. Wherein the visible light range in the transparency test is 380-780 nm; in the agar diffusion toxicity test, a positive control group is a copper sheet, and a negative control group is a titanium sheet. In fig. 1, the lowest part of each line is B, C, A, D and E from top to bottom.
As can be seen from the graphs in FIGS. 1 to 4, compared with the untreated artificial lens material, the artificial lens coating with excellent biological anti-fouling performance obtained by the invention has the advantages that the cell adhesion resistance and the protein adsorption resistance of the modified biological valve are obviously improved, the coating has almost no toxicity to cells, and the coating has excellent biocompatibility. The combination of the transition layer and the functional layer regulates the surface characteristics of the artificial lens, improves the hydrophilicity and biological stain resistance of the surface of the material, improves the biocompatibility of the artificial lens, and effectively prevents or reduces the adhesion of cells, proteins, bacteria and the like on the surface of the lens, the inflammatory reaction and other problems.
While the present invention has been described in detail with reference to the illustrated embodiments, it should not be construed as limited to the scope of the present patent. Various modifications and changes may be made by those skilled in the art without inventive step within the scope of the appended claims.
Claims (10)
1. A preparation method of an artificial lens coating with excellent biological anti-fouling performance is characterized by comprising the following steps:
(1) carrying out low-temperature plasma surface treatment on the surface of the intraocular lens material, then coating an adhesive on the surface of the intraocular lens material, and drying to obtain a transition layer;
(2) and (2) preparing a functional layer coating solution with the concentration of 0.1-30 wt% by using a hydrophilic polymer, then coating the functional layer coating solution on the transition layer obtained in the step (1), and drying to obtain the artificial lens coating with excellent biological anti-fouling performance.
2. The method for preparing an intraocular lens coating with excellent antifouling performance according to claim 1, wherein in step (1), the voltage is 50-150V and the time is 1-90 s during the low-temperature plasma surface treatment.
3. The method for preparing an intraocular lens coating with excellent antifouling performance according to claim 1, wherein the intraocular lens material is rigid polymethyl methacrylate, soft silicone rubber, silicone gel, polyhydroxyethyl methacrylate or hydrophobic acrylate.
4. The method for preparing an intraocular lens coating with excellent antifouling performance according to claim 1, wherein the adhesive is at least one of epoxy resins, animal bone glues, protein glues and acrylate structural glues.
5. The method of preparing an intraocular lens coating with excellent antifouling properties according to claim 1, wherein the hydrophilic polymer is at least one of polyethylene glycol, polyethylene oxide, poly-2-methacryloyloxyethyl phosphorylcholine, polyvinylpyrrolidone, polyacrylic acid, polyvinyl alcohol, hyaluronic acid, collagen, heparin, and hirudin.
6. The method of preparing an intraocular lens coating with excellent biofouling resistance of claim 1 wherein the solvent of the functional layer coating solution is at least one of water, methanol, ethanol, acetone, chloroform and dichloromethane.
7. The method for preparing an intraocular lens coating with excellent antifouling property according to claim 1, wherein in steps (1) to (2), the coating is performed by dip coating, spin coating, drop coating, spray coating or brush coating.
8. The method for preparing an intraocular lens coating with excellent antifouling performance according to claim 1 or 7, wherein in steps (1) - (2), the coating time is 5 s-30 min, and the drying temperature is 30-80 ℃.
9. The artificial lens coating with excellent biological anti-fouling performance, which is prepared by the preparation method of the artificial lens coating with excellent biological anti-fouling performance, according to any one of claims 1 to 8.
10. The intraocular lens coating with excellent biofouling resistance of claim 9, wherein the contact angle of the surface of the intraocular lens coating with excellent biofouling resistance is 0 to 80 °.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010782786.2A CN111729130B (en) | 2020-08-06 | 2020-08-06 | Artificial lens coating with excellent biological anti-fouling performance and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010782786.2A CN111729130B (en) | 2020-08-06 | 2020-08-06 | Artificial lens coating with excellent biological anti-fouling performance and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111729130A true CN111729130A (en) | 2020-10-02 |
| CN111729130B CN111729130B (en) | 2021-07-20 |
Family
ID=72658135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010782786.2A Active CN111729130B (en) | 2020-08-06 | 2020-08-06 | Artificial lens coating with excellent biological anti-fouling performance and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111729130B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113413237A (en) * | 2021-06-01 | 2021-09-21 | 温州医科大学 | Surface-modified artificial lens with degradable drug sustained-release coating with concentric ring patterns and preparation method thereof |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5007928A (en) * | 1988-05-31 | 1991-04-16 | Canon Kabushiki Kaisha | Intraocular implant having coating layer |
| CN1088513A (en) * | 1992-09-14 | 1994-06-29 | 希巴-盖吉股份公司 | Multilayer material |
| CN1210554A (en) * | 1996-02-09 | 1999-03-10 | 表面溶解实验室公司 | Water-based hydrophilic coating compositions and articles prepared therefrom |
| CN1261288A (en) * | 1997-06-23 | 2000-07-26 | 斯蒂斯生物聚合物公司 | Aderent, flexible hydrogel and medicated coatings |
| CN1460456A (en) * | 2003-06-10 | 2003-12-10 | 浙江大学医学院附属第二医院 | Front surface hydrophilic treated hydrophobic artificial lens and its making method |
| US20070122540A1 (en) * | 2005-11-29 | 2007-05-31 | Bausch & Lomb Incorporated | Coatings on ophthalmic lenses |
| CN103608418A (en) * | 2011-04-29 | 2014-02-26 | Ppg工业俄亥俄公司 | Process for forming an anti-fouling coating system |
| EP2705859A1 (en) * | 2013-02-01 | 2014-03-12 | LensWista AG | Coated intraocular lens and its production |
| CN111110397A (en) * | 2020-01-06 | 2020-05-08 | 中山大学中山眼科中心 | Self-cleaning intraocular lens and preparation method thereof |
-
2020
- 2020-08-06 CN CN202010782786.2A patent/CN111729130B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5007928A (en) * | 1988-05-31 | 1991-04-16 | Canon Kabushiki Kaisha | Intraocular implant having coating layer |
| CN1088513A (en) * | 1992-09-14 | 1994-06-29 | 希巴-盖吉股份公司 | Multilayer material |
| CN1210554A (en) * | 1996-02-09 | 1999-03-10 | 表面溶解实验室公司 | Water-based hydrophilic coating compositions and articles prepared therefrom |
| CN1261288A (en) * | 1997-06-23 | 2000-07-26 | 斯蒂斯生物聚合物公司 | Aderent, flexible hydrogel and medicated coatings |
| CN1460456A (en) * | 2003-06-10 | 2003-12-10 | 浙江大学医学院附属第二医院 | Front surface hydrophilic treated hydrophobic artificial lens and its making method |
| US20070122540A1 (en) * | 2005-11-29 | 2007-05-31 | Bausch & Lomb Incorporated | Coatings on ophthalmic lenses |
| CN103608418A (en) * | 2011-04-29 | 2014-02-26 | Ppg工业俄亥俄公司 | Process for forming an anti-fouling coating system |
| EP2705859A1 (en) * | 2013-02-01 | 2014-03-12 | LensWista AG | Coated intraocular lens and its production |
| CN111110397A (en) * | 2020-01-06 | 2020-05-08 | 中山大学中山眼科中心 | Self-cleaning intraocular lens and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 郑志雯 等: "疏水性聚丙烯酸酯人工晶状体的低温等离子体改性", 《高等学校化学学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113413237A (en) * | 2021-06-01 | 2021-09-21 | 温州医科大学 | Surface-modified artificial lens with degradable drug sustained-release coating with concentric ring patterns and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111729130B (en) | 2021-07-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| He et al. | Polymeric biomaterials | |
| US6187042B1 (en) | Intraocular lens coating compositions | |
| US7083646B2 (en) | Surface modification of functional group-containing intraocular lenses | |
| US10052350B2 (en) | Fabrication of gelatin hydrogel sheet for the transplantation of corneal endothelium | |
| US6454802B1 (en) | Intraocular lens implant for the prevention of secondary cataracts | |
| RU2114579C1 (en) | Prosthesis for carrying out subepithelial implantation operations | |
| US20110160851A1 (en) | Keratoprosthesis | |
| US20080050423A1 (en) | Biopolymer-bioengineered cell sheet construct | |
| CN1101780A (en) | Method and means for preventing secondary cataract | |
| EP1776148A1 (en) | Ophthalmic devices and related methods and compositions | |
| JP2005531363A (en) | Surface modified intraocular lens | |
| CN111110397A (en) | Self-cleaning intraocular lens and preparation method thereof | |
| CN111729130B (en) | Artificial lens coating with excellent biological anti-fouling performance and preparation method thereof | |
| US7569222B2 (en) | Hydrogel membrane composition and use thereof | |
| Lai et al. | Functional biomedical polymers for corneal regenerative medicine | |
| Benson et al. | Polymeric biomaterials | |
| WO1988002622A1 (en) | Collagen-hydrogel lens for promoting epithelial cell growth | |
| Hicks et al. | Keratoprosthesis: preliminary results of an artificial corneal button as a full‐thickness implant in the rabbit model | |
| CN107007879A (en) | A kind of active artificial cornea and preparation method thereof | |
| CN111790006B (en) | Durable and stable hydrophilic anti-fouling coating for intraocular lens and preparation method thereof | |
| CN100344269C (en) | Flexible artificial crystalline lens with phospholipin surface finish and manufacturing method thereof | |
| Tripti et al. | Materials for intraocular lenses (IOLs): Review of developments to achieve biocompatibility | |
| US11737919B2 (en) | Endothelial ocular implant | |
| EP0571535A1 (en) | Collagen hydrogel methods | |
| RU2150956C1 (en) | Method of biocompatible material producing |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |